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Dissertations / Theses on the topic 'Multicenter clinical trial'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Zahnert, Thomas, Hubert Löwenheim, Dirk Beutner, et al. "Multicenter Clinical Trial of Vibroplasty Couplers to Treat Mixed/Conductive Hearing Loss: First Results." Karger, 2016. https://tud.qucosa.de/id/qucosa%3A70599.

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Objective: To evaluate the safety and effectiveness of round window (RW), oval window (OW), CliP and Bell couplers for use with an active middle ear implant. Methods: This is a multicenter, long-term, prospective trial with consecutive enrollment, involving 6 university hospitals in Germany. Bone conduction, air conduction, implant-aided warbletone thresholds and Freiburger monosyllable word recognition scores were compared with unaided preimplantation results in 28 moderate-to-profound hearing-impaired patients after 12 months of follow-up. All patients had previously undergone failed reconst

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2

Stockddale, Cynthia R. "A Comparison of Community-Based Centers versus University-Based Centers in Clinical Trial Performance." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002472.

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3

Pereira, Joanna Tatith. "Longevidade de restaurações adesivas em dentes decíduos posteriores submetidos à remoção total ou seletiva de tecido cariado : um estudo multicêntrico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/152662.

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A técnica da remoção seletiva de tecido cariado (RSTC) para lesões de cárie profundas em dentina de dentes decíduos e permanentes, já é consenso na literatura e é sustentada por pesquisas que demonstram excelentes resultados clínicos, radiográficos e microbiológicos. No entanto, a longevidade de restaurações adesivas realizadas após a RSTC, principalmente na dentição decídua, vem gerando algumas dúvidas e preocupações quanto ao seu desempenho, merecendo esclarecimentos. O objetivo deste estudo randomizado, controlado e multicêntrico foi comparar a taxa de sucesso de restaurações adesivas reali

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4

Hauke, Christina [Verfasser], Alexander [Akademischer Betreuer] Gerlach, and Susanne [Akademischer Betreuer] Zank. "The role of therapist adherence in a multicenter randomized clinical trial of patients with panic disorder and agoraphobia / Christina Hauke. Gutachter: Alexander Gerlach ; Susanne Zank." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1065801068/34.

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5

Xu, Shilin. "Contributions to the statistical analysis of multicenter clinical trials." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239146.

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6

Hardy, Rebecca Jane. "Meta-analysis techniques in medical research : a statistical perspective." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1995. http://researchonline.lshtm.ac.uk/682268/.

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Meta-analysis is now commonly used in medical research. However there are statistical issues relating to the subject that require investigation and some are considered here, from both a methodological and a practical perspective. Each of the fixed effect and the random effects models for meta-analysis are based on certain assumptions and the validity of these is investigated. A formal test of the homogeneity assumption made in the fixed effect model may be performed. Since the test has low power, simulation was used to investigate the power under various conditions. The random effects model in

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7

Familusi, Mary Ajibola. "Analysis of clustered competing risks with application to a multicentre clinical trial." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/23763.

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The usefulness of time-to-event (survival) analysis has made it gain a wide applicability in statistically modelling research. The methodological developments of time-to-event analysis that have been widely adopted are: (i) The Kaplan-Meier method, for estimating the survival function; (ii) The log-rank test, for comparing the equality of two or more survival distributions; (m) The Cox proportional hazards model, for examining the covariate effects on the hazard function; and (iv) The accelerated failure time model, for examining the covariate effects on the survival function. Nonetheless, in

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8

Niangoran, Bessekon. "Apport du monitorage statistique des données dans la gestion des essais cliniques multicentriques en Afrique." Electronic Thesis or Diss., Bordeaux, 2023. http://www.theses.fr/2023BORD0436.

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La qualité des données est une préoccupation fondamentale de la recherche clinique. Pour garantir cette qualité, il faut pratiquer un monitorage continu des données. Les organismes internationaux de régulation des médicaments recommandent que ce monitorage soit ciblé, basé sur une analyse des risques. De cette recommandation a germé le concept de « monitoring statistique centralisé » (MSC) qui consiste à détecter des distributions de variables atypiques dans un centre par rapport aux autres centres. Cette thèse recense les méthodes de MSC existants, en propose de nouvelles, et compare les perf

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9

Rotolo, Federico. "Frailty multi-state models for the analysis of survival data from multicenter clinical trials." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422564.

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Proportional hazards models are among the most popular regression models in survival analysis. Multi-state models generalise them in the sense of jointly considering different types of events along with their interrelations, whereas frailty models introduce random effects to account for unobserved risk factors, possibly shared by groups of subjects. The integration of frailty and multi-state methodology is interesting to control for unobserved heterogeneity in presence of complex event history structures, particularly appealing in multicenter clinical trials applications. In the present thes

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10

Lundberg, Elena. "Growth hormone responsiveness in children : results from Swedish multicenter clinical trials of growth hormone treatment." Doctoral thesis, Umeå universitet, Pediatrik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134569.

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The general aims of the thesis were to study GH responsiveness by estimation of pharmacokinetics and bioavailability of injected recombinant human GH (rhGH), of growth response as gain in heightSDS during childhood and puberty, and IGF-I response as change in circulating IGF-ISDS and IGFBP3SDS. Methods Short children were recruited during 1988–1999 into two national randomized multicentre clinical trials on growth until adult height. A group of 117 GHD patients who had been treated from prepuberty with a single GH dose of 33μg/kg/day for at least 1 year were randomized at onset of puberty eith

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11

Braithwaite, Irene E., Alistair W. Stewart, Robert J. Hancox, et al. "Body mass index and vigorous physical activity in children and adolescents: an international cross-sectional study." Blackwell Publishing Ltd, 2017. http://hdl.handle.net/10757/625724.

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Aim: To examine the relationship between reported vigorous physical activity (VPA) and body mass index (BMI) in children (6–7 years) and adolescents (13–14 years). Methods: In the International Study of Asthma and Allergies in Childhood Phase Three, 75 895 children's parents and 199 502 adolescents answered questions relating to VPA, height and weight. The association between VPA and BMI was analysed using general linear models, adjusting for country gross national index. Results: Compared to children who undertook no VPA, those in the infrequent group (once or twice per week) and those in the

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12

VALENTE, ALESSIA. "Multicentre translational Trial of Remote Ischaemic Conditioning in acute ischaemic Stroke (TRICS)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/403045.

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L’ictus rappresenta la seconda causa di morte a livello globale e la prima causa di disabilità negli anziani. A causa di alcuni limiti di impiego, le principali terapie disponibili, volte a ripristinare il flusso sanguigno attraverso fibrinolisi e/o trombectomia meccanica, possono essere usate solo nel 60% dei pazienti con eziologia ischemica. Per tale motivo, la ricerca preclinica cerca di identificare target terapeutici utili per definire nuovi trattamenti ed estendere l’accesso alle cure. Nessuna nuova strategia terapeutica identificata negli studi preclinici ha però confermato la sua effic

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13

Doyle, Rebecca. "Prohibiting deferred consent can lead to research bias in clinical trials within Paediatric Intensive Care Units." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/406508.

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The conduct of clinical trials under time constraints in the paediatric critical care setting may pose an ethical dilemma for researchers. Many life-saving interventions do not allow adequate time to obtain informed, prospective consent from parents or legal guardians. The rapid decision process in the paediatric critical care environment challenges the ethically accepted gold standard of consent prior to interventional research. In time-critical research, provision is made to obtain consent after the intervention has taken place. This concept is often referred to as deferred consent but may a

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14

Tenório, Marge. "A gestão de redes de pesquisa científica, tecnológica e de inovação em saúde no Brasil." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5137/tde-07122016-151310/.

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Esta tese se pautou nas interfaces entre a estrutura do Sistema Nacional de Inovação em Saúde e o Sistema Nacional de Saúde - componentes estratégicos para os setores econômico e social do país. Abordou-se o marco jurídico institucional que dá sustentação à Ciência e Tecnologia em Saúde, envolvendo o arcabouço político que ampara a inovação tecnológica no país e os sistemas de regulação voltados a garantir sua sustentabilidade. O propósito desta pesquisa foi o de investigar as relações e os padrões que possibilitam o estabelecimento de vínculos entre os atores e ainda favorecem a formação de r

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15

Glasbrenner, Michaela Carla [Verfasser]. "Center weighting factors and treatment effects in multicenter clinical trials : application of the analysis of variance in medicine / Michaela Carla Glasbrenner." Ulm : Universität Ulm. Medizinische Fakultät, 2003. http://d-nb.info/1015354513/34.

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16

Touat, Mahdi. "Mécanismes et implications thérapeutiques de l'hypermutation dans les gliomes Mechanisms and Therapeutic Implications of Hypermutation in Gliomas Mismatch Repair Deficiency in High-Grade Meningioma: A Rare but Recurrent Event Associated With Dramatic Immune Activation and Clinical Response to PD-1 Blockade Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial Hyman DM. BRAF Inhibition in BRAFV600-Mutant Gliomas: Results From the VE-BASKET Study Glioblastoma Targeted Therapy: Updated Approaches From Recent Biology Successful Targeting of an ATG7-RAF1 Gene Fusion in Anaplastic Pleomorphic Xanthoastrocytoma With Leptomeningeal Dissemination Ivosidenib in IDH1-Mutated Advanced Glioma." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL071.

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Une élévation majeure de la charge mutationnelle (hypermutation) est observée dans certains gliomes. Néanmoins, les mécanismes de ce phénomène et ses implications thérapeutiques notamment concernant la réponse à la chimiothérapie ou à l'immunothérapie sont encore mal connus. Sur le plan du mécanisme, une association entre hypermutation et mutations des gènes de la voie de réparation des mésappariements de l'ADN (MMR) a été rapportée dans les gliomes, cependant la plupart des mutations MMR observées dans ce contexte n'étaient pas fonctionnellement caractérisées, et leur rôle dans le développeme

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17

Hsu, Ya Cing, and 許雅晴. "The quality control of PET imaging in multicenter clinical trial." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/99297049473802043353.

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碩士<br>長庚大學<br>醫學影像暨放射科學系<br>100<br>18F-AV-45 and 18F-AV-133 are novel PET tracers for imaging the deposition of amyloid in Alzheimer’s disease and the VMAT2 in dopaminergic neuron degeneration of Parkinson’s disease, respectively. For the purpose of observing the disease progression and the need in clinical diagnosis, we can widely investigate the variation between the control and diseased groups by collecting the data from the multicenter clinical trials. To establish the index of quality control assessment to evaluate the image quality in multicenter clinical trials was the first goal in thi

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18

Chen, Qing-Shui, and 陳清水. "Optimal Number of Centers for Multicenter Clinical Trials." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/38058305974666111893.

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