Relevant bibliographies by topics / Multicenter trial effectiveness

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Multicenter trial effectiveness'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Multicenter trial effectiveness"

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Holbrook, Janet T., John H. Kempen, Nancy A. Prusakowski, Michael M. Altaweel, and Douglas A. Jabs. "Challenges in the design and implementation of the Multicenter Uveitis Steroid Treatment (MUST) Trial – lessons for comparative effectiveness trials." Clinical Trials 8, no. 6 (2011): 736–43. http://dx.doi.org/10.1177/1740774511423682.

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Background Randomized clinical trials (RCTs) are an important component of comparative effectiveness (CE) research because they are the optimal design for head-to-head comparisons of different treatment options. Purpose To describe decisions made in the design of the Multicenter Uveitis Steroid Treatment (MUST) Trial to ensure that the results would be widely generalizable. Methods Review of design and implementation decisions and their rationale for the trial. Results The MUST Trial is a multicenter randomized controlled CE trial evaluating a novel local therapy (intraocular fluocinolone acet
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Hughes, Susan L. "Effectiveness of Team-Managed Home-Based Primary CareA Randomized Multicenter Trial." JAMA 284, no. 22 (2000): 2877. http://dx.doi.org/10.1001/jama.284.22.2877.

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Warden, Diane, A. John Rush, Madhukar Trivedi, Louise Ritz, Diane Stegman, and Stephen R. Wisniewski. "Quality improvement methods as applied to a multicenter effectiveness trial—STAR*D." Contemporary Clinical Trials 26, no. 1 (2005): 95–112. http://dx.doi.org/10.1016/j.cct.2004.11.011.

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Wilson, M. Edward, and Rupal H. Trivedi. "Multicenter Randomized Controlled Clinical Trial in Pediatric Cataract Surgery: Efficacy and Effectiveness." American Journal of Ophthalmology 144, no. 4 (2007): 616–17. http://dx.doi.org/10.1016/j.ajo.2007.06.033.

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Luerti, Massimo, Amerigo Vitagliano, Attilio Di Spiezio Sardo, et al. "Effectiveness of Hysteroscopic Techniques for Endometrial Polyp Removal: The Italian Multicenter Trial." Journal of Minimally Invasive Gynecology 26, no. 6 (2019): 1169–76. http://dx.doi.org/10.1016/j.jmig.2018.12.002.

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Arntz, A. "Schema-focused therapy for borderline personality disorder: Effectiveness and cost-effectiveness, evidence from a multicenter trial." European Psychiatry 23 (April 2008): S65—S66. http://dx.doi.org/10.1016/j.eurpsy.2008.01.238.

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Lund, Jennifer Leigh, Michael Webster-Clark, Alexander P. Keil, Daniel Westreich, Til Sturmer, and Hanna Kelly Sanoff. "Effectiveness of adjuvant FOLFOX versus 5FU for colon cancer treatment in community oncology practice using a hybrid study approach." Journal of Clinical Oncology 38, no. 15_suppl (2020): 7067. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.7067.

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7067 Background: Treatment effects may differ between trials and community settings, in part due to underrepresentation of certain patient subgroups in trials. We used a hybrid approach combining clinical trial and real-world data to compare the effectiveness of adjuvant FOLFOX vs 5FU for stage II-III colon cancer in community oncology practice. Methods: We used Multicenter International Study of Oxaliplatin/5FU-LV in the Adjuvant Treatment of Colon Cancer (MOSAIC) combined with patients who met trial eligibility criteria within US Oncology from 1/1/2008-5/31/2019. In the combined data, we use
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Hidler, Joseph, Diane Nichols, Marlena Pelliccio, et al. "Multicenter Randomized Clinical Trial Evaluating the Effectiveness of the Lokomat in Subacute Stroke." Neurorehabilitation and Neural Repair 23, no. 1 (2008): 5–13. http://dx.doi.org/10.1177/1545968308326632.

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Objective. To compare the efficacy of robotic-assisted gait training with the Lokomat to conventional gait training in individuals with subacute stroke. Methods. A total of 63 participants <6 months poststroke with an initial walking speed between 0.1 to 0.6 m/s completed the multicenter, randomized clinical trial. All participants received twenty-four 1-hour sessions of either Lokomat or conventional gait training. Outcome measures were evaluated prior to training, after 12 and 24 sessions, and at a 3-month follow-up exam. Self-selected overground walking speed and distance walked in 6 min
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Rodrigues, Ana Luiza Soares, Beatriz Guitton Renaud Baptista de Oliveira, Débora Omena Futuro, and Silvia Regina Secoli. "Effectiveness of papain gel in venous ulcer treatment: randomized clinical trial." Revista Latino-Americana de Enfermagem 23, no. 3 (2015): 458–65. http://dx.doi.org/10.1590/0104-1169.0381.2576.

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OBJECTIVE: to assess the effectiveness of 2% papain gel compared to 2% carboxymethyl cellulose in the treatment of chronic venous ulcer patients.METHOD: randomized controlled clinical trial with 12-week follow-up. The sample consisted of 18 volunteers and 28 venous ulcers. In the trial group, 2% papain gel was used and, in the control group, 2% carboxymethyl cellulose gel.RESULTS: the trial group showed a significant reduction in the lesion area, especially between the fifth and twelfth week of treatment, with two healed ulcers and a considerable increase in the amount of epithelial tissue in
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Busso, Mariano, Marion Moers-Carpi, Ragnar Storck, Patricia Ogilvie, and Alexandra Ogilvie. "Multicenter, Randomized Trial Assessing the Effectiveness and Safety of Calcium Hydroxylapatite for Hand Rejuvenation." Dermatologic Surgery 36, Sup 1 (2010): 790–97. http://dx.doi.org/10.1111/j.1524-4725.2010.01568.x.

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Dissertations / Theses on the topic "Multicenter trial effectiveness"

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Leichsenring, Falk, Jürgen Hoyer, Manfred Beutel, et al. "The Social Phobia Psychotherapy Research Network: The First Multicenter Randomized Controlled Trial of Psychotherapy for Social Phobia: Rationale, Methods and Patient Characteristics." Karger, 2009. https://tud.qucosa.de/id/qucosa%3A27526.

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This paper presents the Social Phobia Psychotherapy Research Network. The research program encompasses a coordinated group of studies adopting a standard protocol and an agreed-on set of standardized measures for the assessment and treatment of social phobia (SP). In the central project (study A), a multicenter randomized controlled trial, refined models of manualized cognitive-behavioral therapy and manualized short-term psychodynamic psychotherapy are compared in the treatment of SP. A sample of 512 outpatients will be randomized to either cognitive-behavioral therapy, short-term psychodynam
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GIRLANDA, Francesca. "LAST-RD STUDY – LITHIUM AND STANDARD THERAPY IN RESISTANT DEPRESSION. RANDOMIZED EVALUATION OF THE EFFECTIVENESS OF LITHIUM IN SUBJECTS WITH TREATMENT-RESISTANT DEPRESSION AND SUICIDE RISK. AN INDEPENDENT, PRAGMATIC, MULTICENTRE, PARALLEL-GROUP, SUPERIORITY TRIAL." Doctoral thesis, 2014. http://hdl.handle.net/11562/707569.

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Introduzione: Nella depressione resistente al trattamento (DRT), le idee autolesive e suicidarie rappresentano sintomi psicopatologici allarmanti. Questi possono portare a gesti autolesivi e tentativi di suicidio e, nel 10 % dei casi, a suicidi completi. Il trattamento conseguente al comportamento suicidario non-fatale è rilevante per la prevenzione del suicidio, perché il rischio di suicidio in seguito a gesti autolesivi è notevole. Obiettivo: L'obiettivo primario dello Studio LAST è valutare se il litio è efficace nel ridurre il rischio di suicidio in soggetti con DRT e rischio di suicidio.
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Books on the topic "Multicenter trial effectiveness"

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Mecca, Adam P., and Rajesh R. Tampi. Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer’s Disease. Edited by Ish P. Bhalla, Rajesh R. Tampi, Vinod H. Srihari, and Michael E. Hochman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190625085.003.0015.

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This chapter provides a summary of the Clinical Antipsychotic Trials of Intervention Effectiveness—Alzheimer’s disease (CATIE-AD), a multicenter trial that investigated whether atypical antipsychotics are an effective treatment for psychosis, aggression, or agitation in outpatients with Alzheimer’s disease. The chapter briefly reviews the study design, as well as implications and limitations. A relevant clinical case concludes the chapter. In summary, atypical antipsychotic use for up to 36 weeks did not lead to clinical improvement based on time to discontinuation, or symptom reduction. Risk
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Book chapters on the topic "Multicenter trial effectiveness"

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Mitchell, Chris, Monil Karia, and Peter Domos. "UK DRAFFT." In 50 Studies Every Orthopaedic Surgeon Should Know. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780190096656.003.0006.

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Abstract The Distal Radius Acute Fracture Fixation Trial (DRAFFT) is a multicenter randomized trial that compared the functional outcomes of Kirschner wire (K-wire) fixation vs. open reduction and internal fixation (ORIF) with locking plate for dorsally displaced extra-articular distal radius fractures that were reducible using a closed technique. Functional outcomes, radiographic parameters, and cost effectiveness were compared at twelve months postoperatively. Locking plates were associated with statistically significant improvement in radiographic findings of unknown clinical significance.
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Penman, Alan D., Kimberly W. Crowder, and William M. Watkins. "Systemic Anti-Inflammatory Therapy Versus Fluocinolone Acetonide." In 50 Studies Every Ophthalmologist Should Know. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190050726.003.0043.

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The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study was a randomized, partially-masked, parallel treatment, comparative effectiveness trial comparing surgically placed fluocinolone acetonide intravitreous implant to systemic corticosteroids for the treatment of intermediate uveitis, posterior uveitis, and panuveitis. Systemic and implant therapies yielded similar visual outcomes through 54 months of treatment. Given the greater cost of implant therapy for bilateral disease, and the higher risk of ocular complications in the implant arm of the trial, systemic therapy may
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"Epidural Anesthesia and Analgesia in High-Risk Patients Undergoing Major Surgery." In 50 Studies Every Anesthesiologist Should Know, edited by Anita Gupta, Elena N. Gutman, Michael E. Hochman, Anita Gupta, Elena N. Gutman, and Michael E. Hochman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190237691.003.0043.

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This case focuses on the effectiveness of using an epidural in high-risk patients undergoing surgery by asking the question: Do intraoperative epidural anesthesia and postoperative analgesia in high-risk patients presenting for major surgery decrease adverse outcomes compared with alternative analgesic regimens? This multicenter, randomized trial demonstrated improved pain control and a reduction in postoperative respiratory complications with the use of an epidural for intraoperative anesthesia and postoperative analgesia in high-risk patients undergoing major surgery. A significant effect on
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Hamilton, Thomas W., and Abtin Alvand. "Total or Partial Knee Replacement for Treating Medial Compartment Osteoarthritis." In 50 Studies Every Orthopaedic Surgeon Should Know. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780190096656.003.0032.

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Abstract The Total or Partial Knee Arthroplasty Trial (TOPKAT) was a pragmatic, multicenter randomized controlled trial designed to assess the clinical and cost effectiveness of total knee replacement (TKR) compared to partial knee replacement (PKR) in patients with medial compartment osteoarthritis (OA) of the knee. Randomizing 531 patients at five years, TOPKAT reported that there was no difference in functional outcomes, health-related quality of life, patient satisfaction, or revision rates between groups; however, TKR was associated with an increase in complications, particularly knee sti
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Myttaraki, Evangelia, and Christopher Gale. "Effectiveness of Family Integrated Care in Neonatal Intensive Care Units on Infant and Parent Outcomes." In 50 Studies Every Neonatologist Should Know, edited by Susanne Hay, Roger F. Soll, Barbara Schmidt, Haresh Kirpalani, and John Zupancic. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197646953.003.0050.

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Abstract Effective integration of parents in their newborn’s care is critical. This study evaluated the effect of Family Integrated Care (FICare), a pragmatic approach to enable parents to become their newborn’s primary caregivers in the NICU. In this international, multicenter, cluster-randomized controlled trial, 13 centers (895 infants) randomized to FICare were compared to 12 centers (891 infants) randomized to standard parental neonatal care. The primary outcome of infant weight gain at day 21 was greater in the FICare group (Z –0.071 [SD 0.42] versus –0.155 [0.42]; p <0.0002). Sec
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Banach, Alexandra, Hannes Ulrich, Björn Kroll, Alexander Kiel, Josef Ingenerf, and Ann-Kristin Kock-Schoppenhauer. "APERITIF – Automatic Patient Recruiting for Clinical Trials Based on HL7 FHIR." In Studies in Health Technology and Informatics. IOS Press, 2021. http://dx.doi.org/10.3233/shti210120.

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Clinical trials are carried out to prove the safety and effectiveness of new interventions and therapies. As diseases and their causes continue to become more specific, so do inclusion and exclusion criteria for trials. Patient recruitment has always been a challenge, but with medical progress, it becomes increasingly difficult to achieve the necessary number of cases. In Germany, the Medical Informatics Initiative is planning to use the central application and registration office to conduct feasibility analyses at an early stage and thus to identify suitable project partners. This approach ai
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"Multicenter and Multinational Trials." In Statistical Analysis of Cost-effectiveness Data. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470856289.ch8.

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"Obligations to Participants Harmed in the Course of the N–9 Multicenter Vaginal Microbicide Trial in South Africa." In Ethical Issues in International Biomedical Research, edited by James V. Lavery, Christine Grady, Elizabeth R. Wahl, and Ezekiel J. Emanuel. Oxford University PressNew York, NY, 2007. http://dx.doi.org/10.1093/oso/9780195179224.003.0020.

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Abstract Socioeconomic inequalities between men and women in developing countries make women significantly more vulnerable to HIV infection. Women often encounter resistance, even violence and abandonment, for suggesting that their partners use condoms. Effective vaginal microbicides could provide women with a way to protect themselves from disease, especially in situations in which male sexual partners are unwilling to wear condoms and where resisting sexual intercourse may place the women at risk of violence. Consequently, in recent years, a global effort has been made to develop practical s
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Ge, Zhengqiu. "Clinical Perspective: EEG-Based Neuromodulation Technique for Epilepsy." In Studies in Health Technology and Informatics. IOS Press, 2023. http://dx.doi.org/10.3233/shti230889.

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Epilepsy is the most common brain disorder around the world. The main treatments of epilepsy are through drug treatment or epilepsy surgery. However, examples of EEG-based neuromodulation treatments, such as Vagus nerve stimulation (VNS), thalamic deep brain stimulation (DBS), and responsive neuro-stimulation (RNS), are also promising therapeutic methods nowadays. The aim of the paper is to recognize the effectiveness and potential risks of the three techniques. By carrying out randomized multicenter double-blind trials, this research studied the effectiveness of VNS, RNS, and DBS by measuring
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Venkatakiran, S., and Suman vashist. "Augmented and Virtual Reality Applications in Medical Training and Treatment." In Intelligent Healthcare System. RADemics Research Institute, 2025. https://doi.org/10.71443/9789349552210-15.

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The integration of Augmented Reality (AR) and Virtual Reality (VR) technologies into medical training and therapeutic practices was revolutionizing healthcare by providing immersive, interactive environments for skill development and patient care. However, despite their growing applications, significant challenges remain in the standardization, validation, and widespread adoption of AR/VR tools across diverse clinical settings. This chapter examines the current landscape of AR/VR in medical education and therapy, addressing key obstacles such as institutional resistance, regulatory uncertainty
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Conference papers on the topic "Multicenter trial effectiveness"

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Esfahani, K., A. Aspler, D. Menzies, and K. Schwartzman. "Rifampin vs. Isoniazid for Treatment of Latent Tuberculosis: A Cost-Effectiveness Analysis Based on a Multicenter Clinical Trial." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1018.

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Londero, Emily Calmon, and Ana Beatriz Cazé Cerón. "Effectiveness of Music Therapy for the Treatment of Movement Disorders in Parkinson’s Disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.705.

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Introduction: Body movement is synchronized by external rhythmic stimuli in conjunction with physiological control, based on an internal timing process. In this perspective, music therapy can be a potential therapeutic tool for the treatment of individuals with movement disorders as it bypasses an internal rhythm motor deficit. Objective: To evaluate the benefit of music therapy in the treatment of movement disorders in patients with Parkinson’s disease (PD). Methods: This study is a literary review, which used the PubMed platform, in April 2021, with the formula: (MOVEMENT DISORDERS) AND (MUS
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Alatar, Abdullah, Saad Alsaleh, Ashwag Alqurashi, et al. "Effectiveness of Preoperative Antiseptic Preparation in Endoscopic Transnasal Skull Base Surgery: A Randomized Three-Arm Multicenter Controlled Trial: Preliminary Results." In 31st Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1743672.

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Isetta, Valentina, Miguel A. Negrín, Carmen Monasterio, et al. "A bayesian cost-effectiveness analysis of a telemedicine-based strategy for the management of sleep apnea: A multicenter randomized controlled trial." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa3376.

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Ergan, Begüm, Tugba Goktalay, Pinar Ergun, et al. "A multicenter randomized trial for the effectiveness of structured discharge and follow-up protocol on readmission rate in COPD patients receiving LTOT/NIV: one-year interim analysis." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.oa5410.

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Hermans, K., C. Webers, A. Boonen, H. E. Vonkeman, and A. Van Tubergen. "OP0120 EFFECTIVENESS AND COST-EFFECTIVENESS OF PATIENT-INITIATED FOLLOW-UP SUPPORTED BY ASYNCHRONOUS TELEMONITORING IN SPONDYLOARTHRITIS (TeleSpA-STUDY): A PRAGMATIC MULTICENTRE RANDOMISED CONTROLLED TRIAL." In EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.1071.

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Vassallo, R., M. Maida, A. Zullo, et al. "Effectiveness of 1-L polyethylene glycol plus ascorbate versus 4-L polyethylene glycol for colonoscopy cleansing in split-dose: a multicentre, randomized, clinical trial (OVER2019)." In ESGE Days 2023. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1765157.

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Postma, EL, E. Koffijberg, HM Verkooijen, AJ Witkamp, MA van den Bosch, and R. van Hillegersberg. "Abstract P5-15-03: Cost-effectiveness of ‘radioguided occult lesion localization’ (ROLL) versus ‘wire-guided localization’ (WGL) in breast conserving surgery for non-palpable breast cancer: results from a randomized controlled multicentre trial." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p5-15-03.

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