Relevant bibliographies by topics / Multicomponent Reaction

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
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Academic literature on the topic 'Multicomponent Reaction'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 June 2025

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Journal articles on the topic "Multicomponent Reaction"

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Jørgensen, K., A. Carlone, S. Cabrera, and M. Marigo. "Multicomponent Domino Reaction." Synfacts 2007, no. 3 (2007): 0321. http://dx.doi.org/10.1055/s-2007-968238.

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Boltjes, André. "Ugi Multicomponent Reaction." Organic Syntheses 94 (2017): 54–65. http://dx.doi.org/10.15227/orgsyn.094.0054.

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Zhu, Shizheng, Yong Xu, and Guifang Jin. "A novel synthesis of N-fluoroalkanesulfonylamidines using a three-component reaction." Canadian Journal of Chemistry 81, no. 4 (2003): 265–68. http://dx.doi.org/10.1139/v03-032.

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A novel, general, and efficient multicomponent reaction of fluoroalkanesulfonyl azides, secondary amines, and carbonyl compounds for the synthesis of N-fluoroalkanesulfonylamidines is presented. This reaction gave a good yield of products under very mild reaction conditions.Key words: multicomponent reactions, synthetic methods, N-fluoroalkanesulfonyl azide, N-fluoroalkanesulfonylamidine.
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Shaabani, Ahmad, Hassan Farhid, Mohammad Mahdi Rostami, and Behrouz Notash. "Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions." SynOpen 05, no. 03 (2021): 167–72. http://dx.doi.org/10.1055/a-1533-3823.

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AbstractAn efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions. 3-Carboxamido-isobutyric acids bearing an amide bond were obtained via Bargellini multicomponent reaction from isocyanides, acetone, and chloroform in the presence of sodium hydroxide. Next, via a Passerini multicomponent-reaction strategy, a new class of depsipeptides was synthesized using the Bargellini reaction products, isocyanides, and aldehydes. The depsipeptides thus prepared have more flexible structures than their pseudopeptidic analogues.
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Thirumeni, Subramanian, Choumini Balasanthiran, and Grigoriy Sereda. "The Catalytic Activity of TiO2 Toward a Multicomponent Reaction Depends on its Morphology, Mechanoactivation and Presence of Visible Light." Journal of Photocatalysis 1, no. 1 (2020): 37–42. http://dx.doi.org/10.2174/2665976x01666200128150101.

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Aims: Test the hypothesis that the catalytic activity of TiO2 nanoparticles towards a liquidphase or mechanoactivated multicomponent reaction can be tuned by visible light and the shape of nanoparticles. Background: Catalytic multicomponent reactions have been proven to be excellent synthetic approaches to a series of biologically relevant compounds including 2-amino-4H-benzo[b]pyrans. However, the potential photocatalytic activity and structural diversity of nanostructured catalysts remained underutilized in the design of new catalytic systems. Objective: Harness the photocatalytic potential and diverse morphology of TiO2 particles as catalysts for the liquid phase and mechanoactivated multicomponent organic reactions. Results: Catalytic activity of TiO2 nanoparticles towards multicomponent synthesis of 2-amino-4Hbenzo[ b]pyrans is increased by visible light. The nanorod-shaped TiO2 nanoparticles have shown substantially higher catalytic activity towards mechanoactivated multicomponent synthesis of 2- amino-4H-benzo[b]pyrans than their spherically-shaped counterparts. Conclusion: : An efficient methodology for the synthesis of 2-amino-4H-benzo[b]pyrans under ambient light condition has been developed using TiO2 nanorods (high aspect ratio anatase nanocrystals) as photocatalyst. This simple method furnished the corresponding terahydrobenzopyrans in high yields via three component reaction of aldehyde, malononitrile, and dimidone under solvent free reaction conditions at room temperature. The reaction takes 8-10 min at room temperature under ambient light condition and the catalyst can be reused multiple times. Utilization of light and the nanorod morphology of the catalyst through mechanoactivation has been applied for the -first time to the synthetic technique of multicomponent reactions. The synthetic procedures for 2-amino-4Hbenzo[ b]pyrans have been improved.
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Huang, Yijun, and Alexander Dömling. "The Gewald multicomponent reaction." Molecular Diversity 15, no. 1 (2010): 3–33. http://dx.doi.org/10.1007/s11030-010-9229-6.

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Mardjan, Muhammad Idham Darussalam, Jean Luc Parrain та Laurent Commeiras. "Copper-Catalyzed-Multicomponent Reaction towards the Synthesis of γ-Hydroxybutyrolactams". Materials Science Forum 1061 (26 травня 2022): 151–56. http://dx.doi.org/10.4028/p-yux0t7.

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Copper-catalyzed-multicomponent reaction has been applied to prepare several examples γ-hydroxybutyrolactams. The synthesis of γ-hydroxybutyrolactams occurred via cascade sequence comprising Sonogashira coupling, heterocyclization and nucleophilic addition reactions. The reaction involved the starting materials of (Z)-3-iodobutenoic acid, terminal alkynes and butylamine. The results showed that electronic effect of terminal alkynes played important role in synthesis of γ-hydroxybutyrolactams. The multicomponent reaction allowed us to obtain the desired products and to create multiple bonds in one-pot fashion.
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Fan, Xia, Rongshun Chen, Jie Han, and Zhengjie He. "Convergent Synthesis of Polysubstituted Furans via Catalytic Phosphine Mediated Multicomponent Reactions." Molecules 24, no. 24 (2019): 4595. http://dx.doi.org/10.3390/molecules24244595.

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Tri- or tetrasubstituted furans have been prepared from terminal activated olefins and acyl chlorides or anhydrides by a multicomponental convergent synthesis mode. Instead of stoichiometric nBu3P, only catalytic nBu3P or nBu3P=O is needed to furnish the furans in modest to excellent yields with a good functional group tolerance under the aid of reducing agent silane. This synthetic method features a silane-driven catalytic intramolecular Wittig reaction as a key annulation step and represents the first successful application of catalytic Wittig reaction in multicomponent cascade reaction.
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Kasar, Sandeep B., and Shankar R. Thopate. "Ultrasonically Assisted Efficient and Green Protocol for the Synthesis of 4H-isoxazol-5-ones using Itaconic Acid as a Homogeneous and Reusable Organocatalyst." Current Organocatalysis 6, no. 3 (2019): 231–37. http://dx.doi.org/10.2174/2213337206666190411115402.

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Background: Multicomponent reactions involve the simultaneous reaction of three or more components which deliver the product that incorporates the elements of all starting materials. A combination of multicomponent reaction and green solvents like water and the use of nonconventional energy sources like microwave or ultrasonication are important features of ideal green synthesis. Therefore, the design of a new multicomponent reaction and improvement of an already known multicomponent reaction with a green procedure has attracted the attention of the scientific community. Isoxazole derivatives are well known for their biological activities such as antifungal, analgesic, antitumor, antioxidant, antimicrobial, COX-2 inhibitory, anti-inflammatory, antiviral, and antimycobacterial. Objective: To develop a green methodology for the synthesis of 4H-isoxazol-5-ones derivatives. Results: Itaconic acid was used as a green catalyst for the synthesis of 4H-isoxazol-5-ones derivatives under conventional as well as ultrasound irradiation technique. Ultrasound irradiation condition requires less time for the completion of the reaction and also the yields were better. Methods: We have reported Itaconic acid as a green homogenous organocatalyst under ultrasound irradiation for the synthesis of 4H-isoxazol-5-ones derivatives. Conclusion: In conclusion, we have developed a green methodology for the synthesis of 4Hisoxazol- 5-ones derivatives. Itaconic acid is used as an organocatalyst which is biodegradable and nonhazardous. Water is used as a green solvent. Ultrasonication is used as a non-conventional green energy source. Ambient reaction conditions are used to carry out transformation for multicomponent reaction. Metal-free, mineral acid-free synthesis are key features of the present protocol.
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Boukis, Andreas C., Baptiste Monney, and Michael A. R. Meier. "Synthesis of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones via sequential Biginelli and Passerini reactions." Beilstein Journal of Organic Chemistry 13 (January 9, 2017): 54–62. http://dx.doi.org/10.3762/bjoc.13.7.

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The Biginelli reaction was combined with the Passerini reaction for the first time in a sequential multicomponent tandem reaction approach. After evaluation of all possible linker components and a suitable solvent system, highly functionalized dihydropyrimidone–α-acyloxycarboxamide compounds were obtained in good to excellent yields. In a first reaction step, different 3,4-dihydropyrimidin-2(1H)-one acids were synthesized, isolated and fully characterized. These products were subsequently used in a Passerini reaction utilizing a dichloromethane/dimethyl sulfoxide solvent mixture. By variation of the components in both multicomponent reactions, a large number of structurally diverse compounds could be synthesized. In addition, a one-pot Biginelli–Passerini tandem reaction was demonstrated. All products were carefully characterized via 1D and 2D NMR as well as IR and HRMS.
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Dissertations / Theses on the topic "Multicomponent Reaction"

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Jia, Shuanglong. "Multicomponent Reactions toward Heterocycles and Tsuji-Trost Reaction of Allylic Nitro Derivatives." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLY012/document.

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Les réactions multicomposantes jouent un rôle important en chimie organique. Ce sont des réactions qui mettent en jeu au moins trois réactifs de départ et qui permettent d’obtenir des produits considérés comme des éléments intéressants pour la synthèse de molécules complexes ou de composés bioactifs. Grâce à leur versatilité, ces réactions sont considérées comme des outils précieux pour la préparation de bibliothèques de composés organiques dans le domaine de la recherche pharmaceutique et de la synthèse de produits naturels.La réaction de Passerini, combinée à une addition de Michael et à une cyclisation, a permis un accès facile à des γ-butyrolactones avec de bons rendements. Les adduits de Passerini issus d’aldéhydes aromatiques ont été utilisés comme nucléophiles lors d’additions de Michael avec l'acrylonitrile. La réaction s’est déroulée conjointement avec l'hydrolyse de l'ester. Les γ-hydroxynitriles résultant ont pu être cyclisés dans des conditions acides pour former des γ-butyrolactones.Les NH-aryl hydrazones dérivées du trifluoroacétaldéhyde hémiacétal ont pu être impliquées dans des réactions de type Mannich efficaces avec le formaldéhyde et des aldéhydes aromatiques. Les hydrazones résultantes sont des blocs de construction utiles pour la préparation de dérivés 1,2-diazine substitués par un groupement trifluorométhyle sous chauffage avec des β-cetoesters.Enfin, des dérivés naphtalèniques ont pu être obtenus par une réaction de Tsuji-Trost. Le méchanisme de cette réaction passe par la formation d'un complexe -allylique de palladium suivi d'une élimination d’hydrure en  favorisée par une base. Cette réaction, combinée avec la condensation de cétones cycliques avec le nitrométhane et la fonctionnalisation des nitrocycloalcènes résultants (Michael, Mannich ...), constituent un outil synthétique très puissant pour la synthèse de naphtalènes 1-substitués
Multicomponent reactions play a significant role in organic chemistry. They allow the reaction occur between three or more starting materials, providing adducts which are considered as elements for the syntheses of complex molecules with bioactive compounds. Benifiting from their diversity, these reactions are considered as valuable tools for the preparation of libraries of organic structures in the pharmaceutical research and total synthesis of natural products field.The Passerini reaction, combined with Michael addition and cyclisation, served an easy access to γ-butyrolactones with good yields. The Passerini adducts of aromatic aldehydes act as nucleophiles in Michael additions with acrylonitrile. The reaction proceeds together with hydrolysis of the ester. The resulting γ-hydroxynitrile can be cyclized under acidic conditions to afford γ- butyrolactones.The NH-aryl hydrazones derived from trifluoroacetaldehyde hemiacetal can be involved in efficient Mannich type reactions with formaldehyde and aromatic aldehydes. The resulting hydrazones are useful building blocks for the preparation of trifluoromethyl substituted 1,2-diazine derivatives under heating with β-ketoesters.Moreover, naphthalene derivatives may be obtained through Tsuji-Trost reaction. This reaction may involve the formation of a palladium p-allyl complex followed by a base promoted β-hydride elimination. This reaction combined with the condensation of fused cyclic ketones with nitromethane and the functionalization of the resulting nitrocycloalkenes (Michael, Mannich...) constitute a very powerful synthetic tool for the formation of 1-substituted naphtalenes
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Jia, Shuanglong. "Multicomponent Reactions toward Heterocycles and Tsuji-Trost Reaction of Allylic Nitro Derivatives." Electronic Thesis or Diss., Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLY012.

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Les réactions multicomposantes jouent un rôle important en chimie organique. Ce sont des réactions qui mettent en jeu au moins trois réactifs de départ et qui permettent d’obtenir des produits considérés comme des éléments intéressants pour la synthèse de molécules complexes ou de composés bioactifs. Grâce à leur versatilité, ces réactions sont considérées comme des outils précieux pour la préparation de bibliothèques de composés organiques dans le domaine de la recherche pharmaceutique et de la synthèse de produits naturels.La réaction de Passerini, combinée à une addition de Michael et à une cyclisation, a permis un accès facile à des γ-butyrolactones avec de bons rendements. Les adduits de Passerini issus d’aldéhydes aromatiques ont été utilisés comme nucléophiles lors d’additions de Michael avec l'acrylonitrile. La réaction s’est déroulée conjointement avec l'hydrolyse de l'ester. Les γ-hydroxynitriles résultant ont pu être cyclisés dans des conditions acides pour former des γ-butyrolactones.Les NH-aryl hydrazones dérivées du trifluoroacétaldéhyde hémiacétal ont pu être impliquées dans des réactions de type Mannich efficaces avec le formaldéhyde et des aldéhydes aromatiques. Les hydrazones résultantes sont des blocs de construction utiles pour la préparation de dérivés 1,2-diazine substitués par un groupement trifluorométhyle sous chauffage avec des β-cetoesters.Enfin, des dérivés naphtalèniques ont pu être obtenus par une réaction de Tsuji-Trost. Le méchanisme de cette réaction passe par la formation d'un complexe -allylique de palladium suivi d'une élimination d’hydrure en  favorisée par une base. Cette réaction, combinée avec la condensation de cétones cycliques avec le nitrométhane et la fonctionnalisation des nitrocycloalcènes résultants (Michael, Mannich ...), constituent un outil synthétique très puissant pour la synthèse de naphtalènes 1-substitués
Multicomponent reactions play a significant role in organic chemistry. They allow the reaction occur between three or more starting materials, providing adducts which are considered as elements for the syntheses of complex molecules with bioactive compounds. Benifiting from their diversity, these reactions are considered as valuable tools for the preparation of libraries of organic structures in the pharmaceutical research and total synthesis of natural products field.The Passerini reaction, combined with Michael addition and cyclisation, served an easy access to γ-butyrolactones with good yields. The Passerini adducts of aromatic aldehydes act as nucleophiles in Michael additions with acrylonitrile. The reaction proceeds together with hydrolysis of the ester. The resulting γ-hydroxynitrile can be cyclized under acidic conditions to afford γ- butyrolactones.The NH-aryl hydrazones derived from trifluoroacetaldehyde hemiacetal can be involved in efficient Mannich type reactions with formaldehyde and aromatic aldehydes. The resulting hydrazones are useful building blocks for the preparation of trifluoromethyl substituted 1,2-diazine derivatives under heating with β-ketoesters.Moreover, naphthalene derivatives may be obtained through Tsuji-Trost reaction. This reaction may involve the formation of a palladium p-allyl complex followed by a base promoted β-hydride elimination. This reaction combined with the condensation of fused cyclic ketones with nitromethane and the functionalization of the resulting nitrocycloalkenes (Michael, Mannich...) constitute a very powerful synthetic tool for the formation of 1-substituted naphtalenes
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3

LA, SPISA Fabio. "New strategies for novel isocyanide multicomponent reactions: innovative ways to access to medicinally important compounds." Doctoral thesis, Università del Piemonte Orientale, 2015. http://hdl.handle.net/11579/115580.

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Tan, Siu Min. "Multicomponent Diels-Alder Sequences of 1-Aminodendralenes." Phd thesis, Canberra, ACT : The Australian National University, 2017. http://hdl.handle.net/1885/143040.

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This thesis explores the use of in situ generated acyclic 1-aminodendralenes in multicomponent diene-transmissive Diels-Alder (DTDA) reaction sequences. Dendralenes have previously been shown to generate polycyclic frameworks in a step-economic manner. The 1-amino substituent is shown to promote very high levels of site selectivity in these processes. Chapter 1 reviews the Diels-Alder reactions of 1-amino-1,3-butadienes and is divided into three sections. The first two sections cover the Diels-Alder reactions of 1-amino-1,3-butadienes and 1-amino-3-siloxy-1,3-butadienes (Rawal’s dienes) generated with a stoichiometric amount of amine. The third section covers enantioselective Diels-Alder reactions involving 1-amino-1,3-butadienes generated in situ with a catalytic amount of a chiral amine. While there have been many reports of Diels-Alder reactions of 1-amino-1,3-butadienes and 1-amino-3-siloxy-1,3-butadienes, there has been only one involving a semi-cyclic 1-amino[3]dendralene. There have been few examples which combine these Diels-Alder reactions with other transformations in multicomponent reactions to generate polycyclic frameworks. Chapter 2 describes the use of acyclic 1-amino[3]dendralenes in multicomponent reactions to generate a diverse range of heterocyclic structures. The condensation/Diels- Alder reaction sequence was tolerant of a variety of amines as well as carbon and hereoatom-based dienophiles. The Diels-Alder reactions of 1-amino[3]dendralenes were highly site-selective, taking place exclusively at the amine substituted 1,3-butadiene unit. The sequence was extended to a one-pot four-component reaction by including an additional dienophile for a Diels-Alder reaction to take place at the newly generated semi-cyclic diene. These condensation/Diels-Alder/Diels-Alder cycloadducts were generated with high diastereoselectivity, the origins of which were investigated and explained with the use of density functional theory calculations (carried out by Prof Paddon-Row). By reversing the order of events, that is performing a Diels-Alder reaction on the skipped dienal precursor before the condensation/Diels-Alder reaction sequence, constitutional isomers were accessed. The second Diels-Alder reaction could be performed intramolecularly when an amine bearing an alkenyl substituent was used. This condensation/Diels-Alder/intramolecular Diels-Alder reaction sequence furnished a variety of tricyclic and tetracyclic heterocycles. Chapter 3 describes the use of acyclic 1-aminodendralenes bearing chiral amines in organocatalytic, enantioselective Diels-Alder reactions to deliver enantioenriched cycloadducts. The enantioselective Diels-Alder reaction between 1-amino[3]dendralenes, the condensation product of skipped dienals and chiral amines, and various dienophiles followed by elimination of the amine generated trienal cycloadducts in good yield and high enantioselectivity. The reaction tolerates substitution on the skipped dienal as well as dienophiles possessing an aldehyde substituent at the α position. Extension of this methodology by performing Wittig and Diels-Alder reactions on the trienal cycloadducts enabled access to enantioenriched polycyclic products. By using a diene-dialdehyde as the starting precursor, it is anticipated that the Horeau principle would operate in the twofold condensation/Diels-Alder/elimination reaction sequence would furnish the cycloadduct in high enantioselectivity. A preliminary attempt successfully generated the desired cycloadduct as the major product.
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Carmona, Rafaela Costa. "Estratégias assimétricas em reações de acoplamento A3." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-23042013-082023/.

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A presente dissertação de mestrado descreve estudos sobre as reações multicomponentes A3 na versão assimétrica. Diversas metodologias foram empregadas visando a obtenção de propargilaminas opticamente ativas, que são blocos sintéticos versáteis na preparação de compostos bioativos. O trabalho foi dividido em duas partes. Na primeira parte, estudou-se a utilização de aminas opticamente puras como materiais de partida para a reação tricomponente A3. Neste caso, foi utilizada a 2-metilpropan-2-sulfinamida como amina principal, no entanto, o produto de acoplamento não foi obtido, mesmo em diversas condições testadas. Outras aminas opticamente puras, como a (S)- metilbenzilamina e aminas derivadas de amino ácidos, também foram testadas. Os resultados, quanto às razões diastereoisoméricas e rendimento, foram satisfatórios quando aminas derivadas de amino ácidos foram utilizadas, principalmente quando o éster metílico da L-polina foi empregado como fonte de amina, que levou a formação do produto em bom rendimento e uma razão enantiomérica de 15:85. Na segunda parte do trabalho estudou-se a utilização de auxiliares quirais, na reação de A3, como indutores de assimetria. Para tanto, diversos compostos foram testados como oxazolinas opticamente puras e derivados de L-prolina.
This masters thesis describes studies for the asymmetric version of A3 multicomponent reactions. Several methodologies were employed in order to obtain optically active propargylamines, which are versatile synthetic building blocks on the preparation of bioactive compounds. The work was divided into two parts. In the first part, we investigated the use of optically pure amines as starting materials for the A3-coupling reaction. In this case, we used the 2-methylpropan-2-sulfinamide as the main amine, however, the coupling product was not obtained, even under several reaction conditions. Other optically pure amines such as (S)-methylbenzylamine and amines derived from amino acids, were also tested. The yields and diastereomeric excess were satisfactory when amines derived from amino acids were employed, especially when the methyl ester of L-poline was used as amine source, which led to the formation of the product in good yield and diastereoisomeric ratio. In the second part we studied the use of chiral auxiliaries in the A3-coupling reaction to induce the asymmetry. Therefore, several compounds were tested as optically pure oxazolines and L-proline derivatives.
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Howe, Andrew Aitken. "Micro-segregation in multicomponent steels involving the peritectic reaction." Thesis, University of Sheffield, 1993. http://etheses.whiterose.ac.uk/15168/.

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Pereira, Evelin Fornari. "Síntese de compostos α-amino-1,3-dicarbonílicos em microrreator de fluxo contínuo e suas aplicações." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-10082017-114511/.

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Na primeira parte deste trabalho apresentamos uma forma eficiente para sintetizar quinze novos compostos α-amino-1,3-dicarbonílicos através da reação multicomponente de Ugi. Para estas sínteses foi utilizado o microrreator de fluxo contínuo, um aparelho que possibilita uma excelente transferência de calor, de massa e alta relação superfície / volume. Algumas das vantagens em se utilizar um microrreator de fluxo contínuo na síntese são: redução do tempo de reação, aumento de rendimento, seletividade das reações e menor geração de resíduos. Foi possível assim estudar as reações químicas em condições inéditas, variando parâmetros como: temperatura, pressão, tempo de residência e relação estequiométrica. Um comparativo de rendimento da síntese de quatro moléculas foi realizado e pôde-se notar a eficiência do equipamento utilizado, pois os rendimentos obtidos foram superiores quando as mesmas moléculas foram sintetizadas através da reação one-pot. Um scale-up da reação de Ugi também foi realizado e apresentou um resultado satisfatório. Na segunda parte alguns destes compostos foram utilizados como intermediários na formação de uma ligação amídica e também aplicamos a metodologia relacionada à cicloadição catalisada por cobre entre alquinos e azidas na síntese de cinco novos compostos 1,2,3-triazóis. Este foi o primeiro trabalho realizado no Laboratório de Compostos Heterocíclicos da Faculdade de Ciências Farmacêuticas utilizando o microrreator de fluxo contínuo e este equipamento atendeu as necessidades deste trabalho com efetividade.
The first part of this work we present an efficient way to synthesize fifteen new α-amino-1,3-dicarbonyl compounds through the multicomponent Ugi reaction. For these syntheses was used the continuous flow micro-reactor, an equipment that allows an excellent transfer of heat, mass and high surface / volume ratio. Some of the advantages of using a continuous flow micro-reactor in the synthesis are: reduction of reaction time, increase of yield, selectivity of reactions and less generation of residues. It was possible to study the chemical reactions under new conditions, varying parameters such as: temperature, pressure, residence time and stoichiometric ratio. A yield comparison of the synthesis of four molecules was carried out and it was possible to note the efficiency of the equipment used, because the obtained yields were superior when the same molecules were synthesized through the one-pot reaction. A scale-up of the Ugi reaction was also performed and presented a satisfactory result. In the second part some of these compounds were used as intermediates in the formation of an amide bond and we also apply the methodology related to the copper catalyzed cycloaddition between alkynes and azides in the synthesis of five new 1,2,3-triazoles compounds. It was the first work performed in the Laboratory of Heterocyclic Compounds of the Faculty of Pharmaceutical Sciences using the continuous flow micro-reactor and this equipment met the needs of this work with effectiveness.
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Buquoi, John Q. III. "Multicomponent Radical Reactions Incorporating Heteroatom-Carbon Bonds Via Polarity-Reversal Cascades." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574348050305556.

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Stucchi, M. "MULTICOMPONENT APPROACHES TO THE SYNTHESIS OF SMALL BIOACTIVE MOLECULES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/330951.

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In this PhD thesis, we exploited the potentialities of four different multicomponent reactions (MCRs), namely Ugi four-component reaction (U-4CR), N-split Ugi reaction (N-split U-4CR), van Leusen three-component reaction (vl-3CR) and Biginelli reaction (Bg-3CR), developing five different approaches to the synthesis of small bioactive molecules. In particular, we successfully applied the build/couple/pair strategy obtaining a small library of ketopiperazine-based minimalist peptidomimetics, by means of diastereoselective U-4CR/post-cyclization sequences, employing optically pure amino acid-derived α-amino aldehydes and α-isocyanoacetates as starting materials. Computer-assisted NMR NOE analysis allowed us to determine the configuration of the newly formed stereocenters, while molecular dynamics simulation and biological evaluation clearly underlined the potentiality of selected compounds to interfere with protein-protein interactions (PPIs). We also focused our attention on another class of peptide-like compounds, namely diamine-based peptidomimetics, by carefully optimizing the N-split U-4CR conditions for the introduction of N-protected amino acids and α-isocyanoacetates components, in a stereoconservative way. This methodology largely simplifies the synthesis of such compounds, opening the way to the use of more complex secondary diamines, able to induce well-defined secondary structures in the related peptidomimetic and hopefully targeting novel PPIs. Furthermore, by combining the same N-split U-4CR with common transformations, a library of dopamine receptor agonists was rapidly obtained, with biological activities in the nanomolar range. Although the desired D2/D3 selectivity was not achieved, structure-activity relationship (SAR) and docking studies allowed us to understand the key pharmacophoric elements in these novel structures, leading the way to the design of improved molecular scaffolds. By employing the vL-3CR in an iterative way, we designed a novel C2-C5’ linked polyimidazole-based minimalist framework, able to mimic the i, i+1, i+2 and i+3 amino acid residues of a β-strand motif. Its conformational behaviour was investigated through solution-phase NMR and molecular dynamics studies, allowing to demonstrate its ability to mimic a poly-alanine β-strand. Finally, we explored the possibility to combine MCRs with organocatalysis, developing the first BINOL-derived phosphoric acid catalysed Biginelli-like reaction on a ketone. In particular, employing N-substituted isatins as carbonyl substrates, we achieved the synthesis of a small library of biologically relevant enantioenriched spiro[indoline-pyrimidine]-diones derivatives. The assignment of the configuration at the new oxindole C-3 stereocenter was assessed through quantum-mechanical methods and NMR spectroscopy, while computational studies on the reaction transition state allowed us to explain the enantioselectivity and the stereochemical outcome.
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Haigh, Jonathan Michael. "Novel affinity ligands for immunoglobulins based on the multicomponent Ugi reaction." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599837.

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A novel use of the four-component Ugi reaction to generate a solid-phase, immunoglobulin-binding library is described herein. An aldehyde-functionalised Sepharose solid-support constituted one component in the four-component reaction, whereas the other three components (a carboxylic acid, a primary or secondary amine and an isonitrile) were varied in a combinatorial fashion to generate the final tri-substituted scaffold structure which provides a degree of rigidity and functionality suitable for rational investigation of immunoglobulin binding. The Ugi ligand library was initially screened chromatographically against whole human IgG and fragmented (Fc and Fab) molecules. A number of putative lead candidates emerged for whole IgG, in addition to highly specific Fab and Fc-binding ligands. A Fab-specific ligand (A3C1I1) comprising an Ugi scaffold substituted with 1-amino-2-naphthol (A3), glutaric acid (C1) and isopropyl isocyanide (I1) was selected based on its ability to bind Fab differentially over Fc. Preparative chromatography of IgG from human plasma showed 100% of serum IgG was adsorbed from the 20 mg ml-1 crude stock and subsequently eluted with a purity of 81.0% under non-optimised conditions. High purity Fab and IgG isolation was achieved from both yeast and E. coli host cell proteins. The lead candidate was modelled in silico and docked into a human Fab fragment (PDB: 1AQK) to suggest a putative binding interface to the constant CH1-CL Fab terminal through six defined hydrogen bond interactions together with putative hydrophobic interactions. The immobilised ligand was subjected to a series of studies to define an optimised affinity adsorbent which binds 73.06 mg IgG ml-1 moist gel (dynamic binding capacity at 10% breakthrough) and a static binding capacity of 16.1 ± 0.25 mg Fab ml-1 moist resin displaying an affinity constant Kd: (2.6 ± 0.3) x 10-6 M.
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Books on the topic "Multicomponent Reaction"

1

Herrera, Raquel P., and Eugenia Marqués-López, eds. Multicomponent Reactions. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118863992.

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Jieping, Zhu, and Bienaymé Hugues, eds. Multicomponent reactions. Wiley-VCH, 2005.

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Zhu, Jieping, Qian Wang, and Mei-Xiang Wang, eds. Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.

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Orru, Romano V. A., and Eelco Ruijter, eds. Synthesis of Heterocycles via Multicomponent Reactions I. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12675-8.

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Orru, Romano V. A., and Eelco Ruijter, eds. Synthesis of Heterocycles via Multicomponent Reactions II. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-15455-3.

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Orru, Romano V. A. Synthesis of Heterocycles via Multicomponent Reactions II. Springer-Verlag Berlin Heidelberg, 2010.

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Dömling, Alexander. Multicomponent Reaction Chemistry: A Practical Approach. Wiley & Sons, Limited, John, 2023.

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Alexander Dömling. Multicomponent Reaction Chemistry: A Practical Approach. Wiley & Sons, Incorporated, John, 2023.

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Alexander Dömling. Multicomponent Reaction Chemistry: A Practical Approach. Wiley & Sons, Incorporated, John, 2023.

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Alexander Dömling. Multicomponent Reaction Chemistry: A Practical Approach. Wiley & Sons, Incorporated, John, 2023.

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Book chapters on the topic "Multicomponent Reaction"

1

Kappe, C. Oliver. "The Biginelli Reaction." In Multicomponent Reactions. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605118.ch4.

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Suryavanshi, Padmakar, Vijaykumar Paike, Sandeep More, Rajendra P. Pawar, Sandeep B. Mane, and K. L. Ameta. "Synthesis of Functionalized Piperidine Derivatives Based on Multicomponent Reaction." In Multicomponent Reactions. CRC Press, 2017. http://dx.doi.org/10.1201/9781315369754-11.

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Tietze, Lutz F., and Nils Rackelmann. "The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and Related Transformations." In Multicomponent Reactions. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605118.ch5.

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Paike, Vijaykumar, Padmakar Suryavanshi, Sandeep More, Sandeep B. Mane, Rajendra P. Pawar, and K. L. Ameta. "Recent Progress on One-Pot, Multicomponent Reaction for Pyridine Synthesis." In Multicomponent Reactions. CRC Press, 2017. http://dx.doi.org/10.1201/9781315369754-10.

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Hulme, Christopher, Muhammad Ayaz, Guillermo Martinez-Ariza, Federico Medda, and Arthur Shaw. "Recent Advances in Multicomponent Reaction Chemistry." In Small Molecule Medicinal Chemistry. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118771723.ch6.

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Guerrera, Cessandra A., and Todd R. Ryder. "The Petasis Borono-Mannich Multicomponent Reaction." In Boron Reagents in Synthesis. American Chemical Society, 2016. http://dx.doi.org/10.1021/bk-2016-1236.ch009.

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Astarita, Gianni. "Chemical Reaction Engineering of Multicomponent Mixtures: Open Problems." In Chemical Reactions in Complex Mixtures. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-6530-3_1.

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Simoyi, Reuben, Alan Wolf, and Harry Swinney. "One-Dimensional Dynamics in a Multicomponent Chemical Reaction." In Universality in Chaos. CRC Press, 2017. http://dx.doi.org/10.1201/9780203734636-14.

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Scheffelaar, Rachel, Eelco Ruijter, and Romano V. A. Orru. "Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_44.

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Krasavin, Mikhail. "Amine (Imine) Component Surrogates in the Ugi Reaction and Related Isocyanide-Based Multicomponent Reactions." In Isocyanide Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527652532.ch6.

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Conference papers on the topic "Multicomponent Reaction"

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Kumar, N. Naveen, Sonali Ravikumar, Boateng Twum Donkor, et al. "Investigation of Novel Nickel-Based Alloys for High Temperature Molten Chloride Salt Reactor Structural Applications." In AM-EPRI 2024. ASM International, 2024. http://dx.doi.org/10.31399/asm.cp.am-epri-2024p1126.

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Abstract An attempt is being made to develop novel Ni-Mo-W-Cr-Al-X alloys with ICME approach with critical experimental/simulations and processing/microstructural characterization/property evaluation and performance testing has been adopted. In this work, based on thermodynamic modeling five alloy compositions with varying Mo/W and two alloys with high tungsten modified with the addition of Al or Ti were selected and prepared. The newly developed alloys were evaluated for their response to thermal aging in the temperature range of 700 to 850 °C and corrosion in the KCl-NaCl-MgCl2 salt under suitable conditions. Thermally aged and post-corrosion test samples were characterized to ascertain phase transformations, microstructural changes and corrosion mechanisms. Al/Ti modified alloys showed significant change in hardness after 400 hours aging at 750°C, which was found to be due to the presence of fine γ’/γ” precipitates along with plate-shaped W/Mo-rich particles. These alloys show comparable molten salt corrosion resistance as commercial alloys at 750°C for 200-hour exposures. The good corrosion behavior of these alloys may be attributed to the formation of a protective multicomponent Al-or Ti-enriched oxide as well as the unique microstructure.
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Silva, Bruno Henrique Sacoman Torquato da, Lucas Michelão Martins, and Luiz Carlos da Silva-Filho. "Multicomponent Povarov reaction catalyzed by NbCl5." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0112-1.

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Fiorot, R. G., J. F. Allochio Filho, S. G. Greco, V. Lacerda Jr., R. B. dos Santos, and E. V. R. de Castro. "Multicomponent catalytic Mannich Reaction: a methodological study with lawsone." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013915222817.

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Shukla, V., R. K. Sadangi, and B. H. Kear. "Controlled Atmosphere Reaction Plasma Synthesis of Multicomponent Ceramic Powders." In ITSC2004, edited by Basil R. Marple and Christian Moreau. ASM International, 2004. http://dx.doi.org/10.31399/asm.cp.itsc2004p0689.

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Abstract A four inch external diameter copper reaction synthesis tube for attachment to an air plasma spray gun has been designed and constructed. This tube enables the entire hot plasma zone to be enclosed by flowing gas. The tube is water cooled, and enables control of the reaction/melting conditions for the materials that are injected into the plasma as dry powder, slurry or solutions. A supersonic nozzle is also incorporated into the design to promote powder production. Provision for capturing the reaction products in water is made and separation gives the final ceramic powders.
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"Formation of Quinoline derivatives using multicomponent reaction of Isatine." In International Conference on Chemical, Environmental and Biological Sciences. International Institute of Chemical, Biological & Environmental Engineering, 2015. http://dx.doi.org/10.15242/iicbe.c0315064.

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Santos, Giovanny Carvalho dos, Aloisio de Andrade Bartolomeu, and Luiz Carlos da Silva-Filho. "Synthesis of quinolines derivatives by multicomponent reaction promoted by NbCl5." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_201392419018.

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Teng, Ho, Charles M. Kinoshita, and Stephen M. Masutani. "Entropy Generation in Multicomponent Reacting Fluid Flow With Heat and Mass Transfer." In ASME 1996 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/imece1996-0274.

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Abstract A comprehensive equation to determine the rate of local entropy generation in multicomponent, reacting, laminar fluid flow involving heat and mass transfer is formulated based on species-average velocity in a multicomponent continuum. The entropy-generation equation developed in this study suggests that species diffusion induces a diffusive-viscous effect, heretofore not reported in the literature, which could contribute significantly to entropy generation in multicomponent fluid systems, and that entropy generation in a multicomponent system exceeds that in a single-component fluid system having similar velocity and temperature distributions because a greater number of irreversible processes, such as species diffusion, chemical reaction, and the Soret and Dufour effects, are involved. Under appropriate conditions, if the diffusive-viscous effect is neglected, the entropy-generation equation of this study reduces to those reported in the literature for simpler fluid systems based on mean flow.
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Silva, Tiago Lima da, and Paulo Henrique Schneider. "Multicomponent Synthesis of Bifunctional Thiourea Organocatalysts for the Enantioselective Aldol Reaction." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0012-1.

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Martins, Lucas Michelão, Bruno Henrique Sacoman Torquato da Silva, and e. Luiz Carlos da Silva-Filho. "Synthesis of tetrahydropiridines by one-pot multicomponent reaction using Niobium Pentachloride." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0110-1.

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Martins, L. M., B. H. S. T. da Silva, and L. C. Silva-Filho. "Synthesis of tetrahydropiridines by one-pot multicomponent reaction using Niobium Pentaethoxide." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013926121740.

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Reports on the topic "Multicomponent Reaction"

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Sezen, Y. A model of multicomponent droplet evaporation with liquid phase reactions. Office of Scientific and Technical Information (OSTI), 1990. http://dx.doi.org/10.2172/6912806.

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CI Steefel and SB Yabusaki. OS3D/GIMRT software for modeling multicomponent-multidimensional reactive transport. Office of Scientific and Technical Information (OSTI), 2000. http://dx.doi.org/10.2172/754946.

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Malinakova, H. C., and Atsushi Shiota. Final Report for: "Bis-pi-allylpalladium Complexes in Catalysis of Multicomponent Reactions". Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1044605.

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Yeh, G. T., and V. S. Tripathi. HYDROGEOCHEM: A coupled model of HYDROlogic transport and GEOCHEMical equilibria in reactive multicomponent systems. Office of Scientific and Technical Information (OSTI), 1990. http://dx.doi.org/10.2172/6230985.

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Viswanathan, H. S. Modification of the finite element heat and mass transfer code (FEHM) to model multicomponent reactive transport. Office of Scientific and Technical Information (OSTI), 1996. http://dx.doi.org/10.2172/279704.

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Viswanathan, H. S. Modification of the finite element heat and mass transfer code (FEHMN) to model multicomponent reactive transport. Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/541823.

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CHEN, KEN S., GREGORY H. EVANS, RICHARD S. LARSON, DAVID R. NOBLE, and WILLIAM G. HOUF. Final report on LDRD project: A phenomenological model for multicomponent transport with simultaneous electrochemical reactions in concentrated solutions. Office of Scientific and Technical Information (OSTI), 2000. http://dx.doi.org/10.2172/750885.

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