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Dissertations / Theses on the topic 'Multicomponent Reaction'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Jia, Shuanglong. "Multicomponent Reactions toward Heterocycles and Tsuji-Trost Reaction of Allylic Nitro Derivatives." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLY012/document.

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Les réactions multicomposantes jouent un rôle important en chimie organique. Ce sont des réactions qui mettent en jeu au moins trois réactifs de départ et qui permettent d’obtenir des produits considérés comme des éléments intéressants pour la synthèse de molécules complexes ou de composés bioactifs. Grâce à leur versatilité, ces réactions sont considérées comme des outils précieux pour la préparation de bibliothèques de composés organiques dans le domaine de la recherche pharmaceutique et de la synthèse de produits naturels.La réaction de Passerini, combinée à une addition de Michael et à une

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Jia, Shuanglong. "Multicomponent Reactions toward Heterocycles and Tsuji-Trost Reaction of Allylic Nitro Derivatives." Electronic Thesis or Diss., Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLY012.

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Les réactions multicomposantes jouent un rôle important en chimie organique. Ce sont des réactions qui mettent en jeu au moins trois réactifs de départ et qui permettent d’obtenir des produits considérés comme des éléments intéressants pour la synthèse de molécules complexes ou de composés bioactifs. Grâce à leur versatilité, ces réactions sont considérées comme des outils précieux pour la préparation de bibliothèques de composés organiques dans le domaine de la recherche pharmaceutique et de la synthèse de produits naturels.La réaction de Passerini, combinée à une addition de Michael et à une

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3

LA, SPISA Fabio. "New strategies for novel isocyanide multicomponent reactions: innovative ways to access to medicinally important compounds." Doctoral thesis, Università del Piemonte Orientale, 2015. http://hdl.handle.net/11579/115580.

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4

Tan, Siu Min. "Multicomponent Diels-Alder Sequences of 1-Aminodendralenes." Phd thesis, Canberra, ACT : The Australian National University, 2017. http://hdl.handle.net/1885/143040.

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This thesis explores the use of in situ generated acyclic 1-aminodendralenes in multicomponent diene-transmissive Diels-Alder (DTDA) reaction sequences. Dendralenes have previously been shown to generate polycyclic frameworks in a step-economic manner. The 1-amino substituent is shown to promote very high levels of site selectivity in these processes. Chapter 1 reviews the Diels-Alder reactions of 1-amino-1,3-butadienes and is divided into three sections. The first two sections cover the Diels-Alder reactions of 1-amino-1,3-butadienes and 1-ami

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5

Carmona, Rafaela Costa. "Estratégias assimétricas em reações de acoplamento A3." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-23042013-082023/.

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A presente dissertação de mestrado descreve estudos sobre as reações multicomponentes A3 na versão assimétrica. Diversas metodologias foram empregadas visando a obtenção de propargilaminas opticamente ativas, que são blocos sintéticos versáteis na preparação de compostos bioativos. O trabalho foi dividido em duas partes. Na primeira parte, estudou-se a utilização de aminas opticamente puras como materiais de partida para a reação tricomponente A3. Neste caso, foi utilizada a 2-metilpropan-2-sulfinamida como amina principal, no entanto, o produto de acoplamento não foi obtido, mesmo em diversas

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6

Howe, Andrew Aitken. "Micro-segregation in multicomponent steels involving the peritectic reaction." Thesis, University of Sheffield, 1993. http://etheses.whiterose.ac.uk/15168/.

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7

Pereira, Evelin Fornari. "Síntese de compostos α-amino-1,3-dicarbonílicos em microrreator de fluxo contínuo e suas aplicações." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-10082017-114511/.

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Na primeira parte deste trabalho apresentamos uma forma eficiente para sintetizar quinze novos compostos α-amino-1,3-dicarbonílicos através da reação multicomponente de Ugi. Para estas sínteses foi utilizado o microrreator de fluxo contínuo, um aparelho que possibilita uma excelente transferência de calor, de massa e alta relação superfície / volume. Algumas das vantagens em se utilizar um microrreator de fluxo contínuo na síntese são: redução do tempo de reação, aumento de rendimento, seletividade das reações e menor geração de resíduos. Foi possível assim estudar as reações químicas em

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8

Buquoi, John Q. III. "Multicomponent Radical Reactions Incorporating Heteroatom-Carbon Bonds Via Polarity-Reversal Cascades." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574348050305556.

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9

Stucchi, M. "MULTICOMPONENT APPROACHES TO THE SYNTHESIS OF SMALL BIOACTIVE MOLECULES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/330951.

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In this PhD thesis, we exploited the potentialities of four different multicomponent reactions (MCRs), namely Ugi four-component reaction (U-4CR), N-split Ugi reaction (N-split U-4CR), van Leusen three-component reaction (vl-3CR) and Biginelli reaction (Bg-3CR), developing five different approaches to the synthesis of small bioactive molecules. In particular, we successfully applied the build/couple/pair strategy obtaining a small library of ketopiperazine-based minimalist peptidomimetics, by means of diastereoselective U-4CR/post-cyclization sequences, employing optically pure amino acid-de

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10

Haigh, Jonathan Michael. "Novel affinity ligands for immunoglobulins based on the multicomponent Ugi reaction." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599837.

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A novel use of the four-component Ugi reaction to generate a solid-phase, immunoglobulin-binding library is described herein. An aldehyde-functionalised Sepharose solid-support constituted one component in the four-component reaction, whereas the other three components (a carboxylic acid, a primary or secondary amine and an isonitrile) were varied in a combinatorial fashion to generate the final tri-substituted scaffold structure which provides a degree of rigidity and functionality suitable for rational investigation of immunoglobulin binding. The Ugi ligand library was initially screened chr

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11

Chen, Chen. "Affinity ligands for glycoprotein purification based on the multicomponent Ugi reaction." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709063.

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12

Spangenberg, Thomas. "Synthesis of biomolecules using directed allylic substitution, multicomponent reaction and hydroformulation." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13250.

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L'économie d'atomes est un enjeu majeur dans le domaine de la synthèse organique. Dans cette optique, la préparation de cibles d'intérêts biologiques (amino-acides, alcaloïdes) par de nouvelles stratégies de synthèse attire en permanence l'attention des chimistes. [. . . ]<br>Atomökonomische Reaktionen gewinnen in der organische Synthese eine zunehmend an Bedeutung, nicht nur bei der Herstellung einfacher Moleküle sondern auch für strukturell aufwendige und biologisch hochwirksame Moleküle wie z. B. Alkaloide und nicht natürliche Aminosäuren. [. . . ]

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13

Zidan, Alaa. "Multicomponent reactions for the synthesis of some nitrogenous heterocyclic compounds and studies of their biological activities." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLY005/document.

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Les réactions multicomposants représentent un axe de recherche important en chimie organique. La capacité de regrouper en une même réaction plus de trois produits départs est la base de synthèse de molécules complexes proches de composés bioactifs. Par ailleurs, de part leur diversité, ces réactions sont des outils précieux pour la réalisation de librairies dans la recherche pharmaceutique. Les réactions multicomposants à base d'isonitrile, particulièrement la réaction Ugi, sont largement utilisées. Malgré les nombreuses applications de cette réaction, elle souffre encore de nombreuses limitat

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14

Zidan, Alaa. "Multicomponent reactions for the synthesis of some nitrogenous heterocyclic compounds and studies of their biological activities." Electronic Thesis or Diss., Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLY005.

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Les réactions multicomposants représentent un axe de recherche important en chimie organique. La capacité de regrouper en une même réaction plus de trois produits départs est la base de synthèse de molécules complexes proches de composés bioactifs. Par ailleurs, de part leur diversité, ces réactions sont des outils précieux pour la réalisation de librairies dans la recherche pharmaceutique. Les réactions multicomposants à base d'isonitrile, particulièrement la réaction Ugi, sont largement utilisées. Malgré les nombreuses applications de cette réaction, elle souffre encore de nombreuses limitat

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15

Meng, Fanke. "Design of Copper-Catalyzed Multicomponent Reactions and Applications to Natural Product Synthesis." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104876.

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Thesis advisor: Amir H. Hoveyda<br>Chapter 1. Ligand-Controlled Site-Selective NHC–Cu-Catalyzed Protoboration of Monosubstituted Allenes. Site-selective proto–boryl additions to monosubstituted allenes promoted by NHC–Cu complexes are disclosed. Synthetically useful 1,1-disubstituted and Z-trisubstituted alkenylboron compounds are afforded in high efficiency (71%–92% yield) and site selectivity (88% to >98%) through proper choice of NHC ligands. Mechanistic study with the assistance of DFT calculations indicates that protonation of 2-boron-substituted allylcopper complex occurs through six-

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16

Schevciw, Evelyn Pucci. "Reações de acoplamento-A3 visando a síntese da desoxicastanospermina e swainsonina." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-20072015-135552/.

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Esta dissertação de mestrado descreve os resultados obtidos acerca da aplicação de reações de acoplamento entre aldeídos, aminas e alquinos (A3) visando a síntese de alcalóides indolizidínicos de ocorrência natural, como a desoxicastanospermina e a swainsonina. A reação de acoplamento-A3 é uma poderosa ferramenta de construção de ligação carbono-carbono e carbono-heteroátomo, permitindo a preparação de propargilaminas que podem ser exploradas como intermediários de grande potencial sintético. A proposta está baseada na reação de acoplamento de um reagente organometálico, gerado in situ a parti

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17

Yu, Xiaodan. "New functionalized alkylidenecyclobutanes : multicomponent synthesis and applications." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF034.

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Les dérivés du cyclobutane sont devenus de plus en plus importants en tant que blocs de construction moléculaires en raison de leur contrainte cyclique inhérente et de la modification sélective de leurs structures qui peuvent être utilisées de manière stratégique dans la synthèse organique. Les cycles cyclobutane apparaissent également dans les structures moléculaires d'un large panel de molécules naturelles et synthétiques qui présentent des activités biologiques intéressantes. Au sein de cette grande famille, les sous-unités alkylidènecyclobutane sont rencontrées dans des produits naturels,

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18

Oshiro, Paula Beatriz. "Estudos sobre a utilização do pentacloreto de nióbio na síntese de derivados cumarínicos com estrutura doador-π-aceptor com potencial aplicação como corantes sensibilizadores em dispositivos fotoeletroquímicos de Gratzel /". Bauru, 2019. http://hdl.handle.net/11449/182277.

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Orientador: Luiz Carlos da Silva Filho<br>Resumo: Derivados de cumarina representam uma grande e importante classe de produtos naturais com diversas atividades biológicas. Entretanto, com a eletrônica orgânica e a utilização de novos materiais como absorvedores de luz, derivados de cumarina têm despertado grande interesse da comunidade científica. As cumarinas possuem grande absorção na região visível e alto rendimento quântico de fluorescência, o que sugere ser um material promissor para aplicação como corantes em células solares. Entre os métodos de síntese de cumarina descritos na literatur

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19

Rainoldi, G. "A JOURNEY IN THE ORGANOCATALYSED AND MULTICOMPONENT SYNTHESIS OF 3,3-DISUBSTITUTED AND SPIRO-OXINDOLES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/544286.

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2-Oxindoles, especially those 3,3-disubstituted or spiro-fused to other cyclic frameworks, continue to be recognized as valuable compounds for drug discovery. They are present in a large number of natural and unnatural compounds with important biological activities and serve as key intermediates for the synthesis of many kinds of drug candidates.1 In particular, spirooxindoles, having cyclic structures fused at the C3 carbon, move away from the flat heterocycles encountered in many drug discovery programs. For this reason, they are of special interest, being able to potentially provide improve

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20

Bell, Christan Elizabeth. "Synthesis and Reactivity of New Organoboron Reagents and Development of New Methodologies for the Generation of Novel Drug-Like Scaffolds." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/265557.

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This research focused on the synthesis of novel ogranoboron reagents in efforts to perform a variety of synthetic transformations, and additionally, the development of new methodologies to generate drug-like scaffolds. Initially, three novel tripod ligands were synthesized, and two were effectively chelated to boron to provide the desired organoborates. Such organoborates were employed in nucleophilic additions where they were found to be ineffective, whereas some activity was observed in Suzuki-Miyaura cross-coupling reactions. An additional project on organoboron compounds was conducted and

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21

Ng, Kheng Tee. "Novel synthetic affinity ligands based on an Ugi multicomponent reaction for the purification of human antibodies." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709427.

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22

Derdar, Mawaheb M. Zarok. "Experimental and kinetic modelling of multicomponent gas/liquid ozone reactions in aqueous phase. Experimental investigation and Matlab modelling of the ozone mass transfer and multicomponent chemical reactions in a well agitatated semi-batch gas/liquid reactor." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4872.

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Due to the ever increasing concerns about pollutants and contaminants found in water, new treatment technologies have been developed. Ozonation is one of such technologies. It has been widely applied in the treatment of pollutants in water and wastewater treatment processes. Ozone has many applications such as oxidation of organic components, mineral matter, inactivation of viruses, cysts, bacteria, removal of trace pollutants like pesticides and solvents, and removal of tastes and odours. Ozone is the strongest conventional oxidant that can result in complete mineralisation of the organic pol

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23

Derdar, Mawaheb M. Zarok. "Experimental and kinetic modelling of multicomponent gas/liquid ozone reactions in aqueous phase : experimental investigation and Matlab modelling of the ozone mass transfer and multicomponent chemical reactions in a well agitated semi-batch gas/liquid reactor." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4872.

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Due to the ever increasing concerns about pollutants and contaminants found in water, new treatment technologies have been developed. Ozonation is one of such technologies. It has been widely applied in the treatment of pollutants in water and wastewater treatment processes. Ozone has many applications such as oxidation of organic components, mineral matter, inactivation of viruses, cysts, bacteria, removal of trace pollutants like pesticides and solvents, and removal of tastes and odours. Ozone is the strongest conventional oxidant that can result in complete mineralisation of the organic pol

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24

Vicente, García Esther. "Estudios sintéticos sobre la reacción de Povarov, nuevos sustratos y aplicaciones." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/97242.

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La presente tesis doctoral se centra principalmente, en aumentar la variabilidad del componente olefínico presente en la reacción multicomponente de Povarov y procesos relacionados, así como en explorar la posible actividad como inhibidores de AChE de los productos de oxidación de los aductos Povarov. Dentro de este trabajo, se estudió la reactividad de un variado grupo de lactamas insaturadas. En este grupo se varió la sustitución sobre el nitrógeno, la posición del doble enlace (endo- o exo- cíclico) y el tamaño del ciclo (5, 6 y 7). De este modo se obtuvieron las correspondientes tetrah

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25

Argönül, Aykut. "Measurement and calculation of multicomponent-diffusion and reaction in catalyst particles, effect of the catalyst pore structure." Göttingen Cuvillier, 2009. http://d-nb.info/999375121/04.

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26

Murlykina, M. V., M. M. Kornet, der Eycken E. V. Van, Dominique Schols, A. V. Tsygankov, and V. A. Chebanov. "Controlled doebner-, groebke- and ugi-type multicomponent reactions involving aminoazoles with further in vitro antibacterial and antiviral activity evaluation studies of the reaction products." Thesis, Heinrich Heine Universität Düsseldorf, 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/43234.

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27

Molins, Rafa Sergi. "Using the Dusty Gas Model to investigate reaction-induced multicomponent gas and solute transport in the vadose zone." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/431.

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Biogeochemical reactions and vadose zone transport, in particular gas phase transport, are inherently coupled processes. To explore feedback mechanisms between these processes in a quantitative manner, multicomponent gas diffusion and advection are implemented into an existing reactive transport model that includes a full suite of geochemical reactions. Multicomponent gas diffusion is described based on the Dusty Gas Model, which provides the most generally applicable description for gas diffusion. Gas advection is described by Darcy's Law, which in the current formulation, is directly substit

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28

Chabour, Ihssene. "1,3-Dipolar cycloadditions using catalysts with double chirality and novel multicomponent [4+2] processes." Doctoral thesis, Universidad de Alicante, 2021. http://hdl.handle.net/10045/114674.

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In this thesis, different cycloaddition reactions, such as the enantioselective 1,3-dipolar-cycloaddition, which takes place between in situ generated stabilized azomethine ylides, and electrophilic alkenes, and the diastereoselective multicomponent reactions Amine-Aldehyde-Dienophile (AAD) or Phosphoramidate-Aldehyde-Dienophile (PAD) are described. In Chapter 1, an asymmetric 1,3-dipolar cycloaddition reaction involving an imino ester with tert-butyl acrylate was carried out using a silver(I) complex with double chirality, formed from a chiral phosphoramidite and chiral silver binolphosphate(

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29

Selander, Nicklas. "Catalytic Functionalization of Allylic Substrates by Palladium Pincer Complexes." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-39065.

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This thesis is based on the development of novel catalytic reactions for the synthesis and application of organometallic reagents. The main focus is directed towards organoboronate derivatives. We developed an efficient procedure for converting allylic alcohols to the corresponding allylboronates using palladium pincer complexes as catalysts. The reactions were performed under mild conditions with high selectivity, allowing further one-pot transformations. Using this approach, a variety of stereodefined homoallylic alcohols and amino acid derivatives were synthesized via trapping of the in sit

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Jang, Hwanjong. "Efficient and Selective Synthesis of Multifunctional Organoboron Compounds Promoted by Cu-Based N-Heterocyclic Carbene Complexes." Thesis, Boston College, 2016. http://hdl.handle.net/2345/bc-ir:107188.

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Thesis advisor: Amir H. Hoveyda<br>Chapter 1. We have developed a single-vessel catalytic protocol for double protoboryl additions to terminal alkynes with B2(pin)2 promoted by Cu complex derived from chiral N-heterocyclic carbene (NHC), to achieve enantiomerically enriched versatile vicinal diborons. Since an alkenyl(pinacolato)boron, which was in situ generated by the first protoboration of a terminal alkyne, can serve as an effective substrate for the second protoboration (alkenylboron can allow delocalization of π electrons of olefin to a partially vacant p orbital on boron), single-vessel

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Oliveira, Camila de Souza de. "Aplicação de compostos de nióbio para a síntese de moléculas bioativas." reponame:Repositório Institucional da UFABC, 2017.

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Orientadora: Profa. Dra. Mirela Inês de Sairre<br>Tese (doutorado) - Universidade Federal do ABC. Programa de Pós-Graduação em Ciência e Tecnologia/Química, 2017.<br>Cerca de 98% do total de nióbio encontra-se no Brasil, sendo este o maior produtor de mundial com aproximadamente 90%. Neste trabalho serão apresentadas duas reações a Reação Multicomponente de Hanzsch (RMC) e a Reação de Diels-Alder, nas quais foram utilizados compostos de nióbio (pentóxido de nióbio (NBO), oxalato amoniacal de nióbio (ANO), fosfato de nióbio (NBP) e pentacloreto de nióbio) como catalisadores. A primeira reação e

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Ben, Abdessalem Abdelbari. "Réactions multicomposant à base des isonitriles." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLY024/document.

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Les réactions multicomposant à base d'isonitrile (I-MCR) combinées à des transformations de post-condensation constituent des outils de synthèse extrêmement puissants pour la préparation de structures moléculaires complexes et diverses avec de nouvelles propriétés pharmacologiques.Dans un premier temps, nous nous sommes intéressés à l'extension du couplage de Ugi-Smiles aux dérivés de purines, en utilisant la 6-mercaptopurine comme partenaire de couplage. Cette méthodologie permet un accès direct et rapide aux dérivés d'adénine avec des rendements modérés à bons à partir de précurseurs simples

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Poynton, Gary. "Multi-component epoxy resin formulation for high temperature applications." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/multicomponent-epoxy-resin-formulation-for-high-temperature-applications(607ef011-7c34-45aa-a973-cc177d420e5c).html.

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The high functionality epoxy resins tetraglycidyl-4,4’-diaminodiphenyl-methane(TGDDM) and triglycidyl-p-aminophenol (TGPAP) are the main components in most aerospace grade epoxy resin formulations. Owing to their high reactivity and high viscosity, TGDDM and TGPAP pose difficulties when used in wet layup composite manufacturing. As such, these resins are often modified to achieve the desired performance both in the liquid and cured states. The main objective of this thesis is to optimise a low viscosity multi-component epoxy resin formulation suitable for use as an aerospace grade composite ma

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Gariani, Rogério Aparecido. "Preparação de blocos quirais contendo selênio e telúrio via resolução cinética enzimática em CO2 supercrítico e determinação de excessos enantioméricos por RMN de 125Te e calcogenação de olefinas ativadas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-25042011-105743/.

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Esta tese esta dividida em três capítulos: Primeiro capítulo - Resolução cinética enzimática de sulfetos, selenetos e teluretos em CO2 supercrítico. Inicialmente, a estabilidade dos β-hidróxi organocalcogenetos foi avaliada em CO2 supercrítico. Como a variação da pressão e temperatura afeta a densidade do fluído de forma não linear, um estudo sistemático foi realizado para avaliação desses parâmetros, visando altos excessos enantioméricos para os β-hidróxi- sulfetos e -selenetos, os quais foram determinados por cromatografia líquida de alta eficiência (CLAE). Os β-hidróxi-

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Amaral, Alexandra Aparecida do. "Síntese de derivados de 3-Indolil-glicina via reação multicomponente de Aza-Friedel-Crafts e avaliação da atividade fitotóxica." Universidade Estadual do Oeste do Paraná, 2018. http://tede.unioeste.br/handle/tede/4017.

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Submitted by Marilene Donadel (marilene.donadel@unioeste.br) on 2018-11-13T19:40:32Z No. of bitstreams: 1 Alexandra_Amaral_2018.pdf: 6685905 bytes, checksum: ec13a764da46630f5757867d952330fd (MD5)<br>Made available in DSpace on 2018-11-13T19:40:33Z (GMT). No. of bitstreams: 1 Alexandra_Amaral_2018.pdf: 6685905 bytes, checksum: ec13a764da46630f5757867d952330fd (MD5) Previous issue date: 2018-07-31<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>It is notable that with technological advances and scientific research, organic synthesis has provided the synthesis of

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CAPURRO, PIETRO. "Novel photoredox and photoinduced approaches for synthetic applications." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1071626.

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The use of light as activation mode for organic molecules is surely one of the oldest concepts in the universe. In fact, organic photochemistry is almost as old as organic chemistry itself. However, for long time the field remained mostly unexplored, and the applications limited. Only now, with depauperate reserves of fossil fuels, a quest for more sustainable energy sources to feed our processes started. Light, omnipresent on our planet and in the universe, makes the perfect candidate as source of green energy. After more than a hundred years humanity is eventually answering the hopes of Giac

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Nawaz, Faisal. "Design and synthesis of functionalized carbenes as organocatalysts and reaction intermediates." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4369.

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Au cours des dernières années, l'utilisation des carbènes N-hétérocycliques (NHCs) en tant qu'organocatalyseurs a connu un succès impressionnant. Dans ce manuscrit, nous présentons le design et la synthèse de nouveaux organocatalyseurs NHC bifonctionnels, et leurs applications pour la chimie énantiosélective des homoénolates. En parallèle de ces études, une approche conceptuellement nouvelle aux carbènes de pyridine est proposée et exploitée dans une réaction à trois composants originale. Globalement, ce travail contribue au progrès de la connaissance sur l'utilisation des carbènes comme organ

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38

Ben, Abdessalem Abdelbari. "Réactions multicomposant à base des isonitriles." Electronic Thesis or Diss., Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLY024.

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Les réactions multicomposant à base d'isonitrile (I-MCR) combinées à des transformations de post-condensation constituent des outils de synthèse extrêmement puissants pour la préparation de structures moléculaires complexes et diverses avec de nouvelles propriétés pharmacologiques.Dans un premier temps, nous nous sommes intéressés à l'extension du couplage de Ugi-Smiles aux dérivés de purines, en utilisant la 6-mercaptopurine comme partenaire de couplage. Cette méthodologie permet un accès direct et rapide aux dérivés d'adénine avec des rendements modérés à bons à partir de précurseurs simples

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39

Pachón-Angona, Irène. "Synthèse multicomposants et évaluation pharmacologique de molécules multicibles par des réactions d’Ugi et de Hantzsch comme solution pour la maladie d’Alzheimer." Thesis, Bourgogne Franche-Comté, 2019. http://www.theses.fr/2019UBFCE015.

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La maladie d’Alzheimer (MA) est le type de démence le plus courant chez les personnes âgées. Cette neuropathologie est caractérisée par une étiologie extrêmement complexe et interconnectée comprenant un déficit cholinergique, des dépôts amyloïdes, des enchevêtrements neurofibrillaires et un stress oxydatif. L’approche mono-cible traditionnelle est le seul traitement disponible à ce jour, mais il n’est pas efficace pour stopper cette maladie. Des composés multicibles (MTDL en anglais) ont émergé en réponse à cette problématique, capables d'interagir simultanément sur différents facteurs respons

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Dell'Acqua, M. "NEW SYNTHETIC STRATEGIES FOR THE PREPARATION OF HETEROCYCLIC AND HETEROPOLYCYCLIC COMPOUNDS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/170500.

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The aim of the project of this doctoral thesis is the development of new synthetic strategies for the preparation of heterocyclic and heteropolycyclic compounds of potential interest in biological and pharmacological fields. In particular, we studied new general, flexible and regioselective synthetic approaches to oxygen and nitrogen heterocycles. We showed the versatility of nucleophilic addition/annulation domino reactions of alkyne compounds bearing a proximate nucleophile in the synthesis of heterocyclic systems, such as dihydroisobenzofurans, isoquinolines and naphthyridines. These approa

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Cerqueira, Araújo Marco Filipe. "Supramolecular metallogels for application in catalysis." Doctoral thesis, Universitat Jaume I, 2016. http://hdl.handle.net/10803/387304.

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La tesis describe el diseño y la síntesis de geles moleculares funcionalizados con fragmentos catalíticos de feniltriazol (PhTzValn), benciltriazol (BzTzAValn) y azidocoumarinatriazol (RAzTzValn) y su aplicación como catalizadores heterogéneos de la reacción de cicloadición azida-alquino catalizada con cobre (CuAAC). Los gelantes sintetizados demostraron capacidad para complejar el cobre (I), resultando en un aumento de sus propiedades mecánicas. Aparte de la actividad catalítica verificada en la reacción `click' entre la bencilazida y el fenilacetileno, la familia de gelantes PhTzValn demuest

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Martinez, Ariza Guillermo, and Ariza Guillermo Martinez. "Exploiting Molecular Diversity to Access Biologically Relevant Chemotypes." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621718.

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Small-molecule libraries with enhanced structural diversity are of value in drug discovery campaigns where novel biologically active hits are desired. As such, multicomponent reactions (MCRs) have proven fruitful to enhance the molecular diversity of chemical collections and expedite forward progression of the drug discovery chain. Bicalutamide (Casodex), an anticancer drug, and Telaprevir (Incivek), an antiviral, are two examples of marketed drugs that can be synthesized using an MCR. The research topic of this dissertation involves the design, discovery, and development of novel MCRs and new

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Fox, Clayton D. L. "Modeling Simplified Reaction Mechanisms using Continuous Thermodynamics for Hydrocarbon Fuels." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37554.

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Commercial fuels are mixtures with large numbers of components. Continuous thermodynamics is a technique for modelling fuel mixtures using a probability density function rather than dealing with each discreet component. The mean and standard deviation of the distribution are then used to model the chemical reactions of the mixture. This thesis develops the necessary theory to apply the technique of continuous thermodynamics to the oxidation reactions of hydrocarbon fuels. The theory is applied to three simplified models of hydrocarbon oxidation: a global one-step reaction, a two-step reaction

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44

Nawaz, Faisal. "Design and synthesis of functionalized carbenes as organocatalysts and reaction intermediates." Electronic Thesis or Diss., Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4369.

Full text

Abstract:

Au cours des dernières années, l'utilisation des carbènes N-hétérocycliques (NHCs) en tant qu'organocatalyseurs a connu un succès impressionnant. Dans ce manuscrit, nous présentons le design et la synthèse de nouveaux organocatalyseurs NHC bifonctionnels, et leurs applications pour la chimie énantiosélective des homoénolates. En parallèle de ces études, une approche conceptuellement nouvelle aux carbènes de pyridine est proposée et exploitée dans une réaction à trois composants originale. Globalement, ce travail contribue au progrès de la connaissance sur l'utilisation des carbènes comme organ

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45

Esgulian, Mathieu. "Oxyhomologation diastéréosélective de la sérine : développement de la méthodologie MAC." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS392/document.

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La méthodologie MAC consiste à employer des réactifs umpolung pour permettre l’insertion formelle d’une fonction carbonyle entre un électrophile et un nucléophile. Cette thèse est consacrée à l’oxyhomologation diastéréosélective de la L-sérine grâce à un développement significatif de la méthodologie MAC à trois composants en one-pot, conduisant à l’obtention de dérivés orthogonalement protégés de l’acide α, γ-dihydroxy-β-aminobutyrique. Ce dernier est une brique moléculaire acyclique à 4 atomes de carbone hautement fonctionnalisée qui est souvent intégrée dans les squelettes de molécules biolo

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46

Pignon, Antoine. "Réactions multicomposants aux organométalliques : nouveaux développements et application à la préparation d'hétérocycles azotés." Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1035.

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Les réactions multicomposants sont des réactions faisant intervenir au minimum trois composés pour la préparation d'un produit contenant la majeure partie des atomes de départ. Elles constituent l'un des procédés les plus performants en synthèse organique. En diminuant les coûts et les rejets par rapport aux réactions classiques de chimie organique, elles sont également plus économes et plus respectueuses de l'environnement. De plus, en permettant la formation rapide et efficace d'une large librairie de molécules complexes à partir de substrats simples, elles représentent un outil à forte vale

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Lear, Jeremy M. "Polarity-Reversal Cascades for the Coupling of Radicals with Unsaturated Systems." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1562958629394222.

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PACIFICO, Salvatore. "Sintesi di glicopeptidi mediante le reazioni tiol-ene/ino e studio della reattività di Umpolung di α-dichetoni". Doctoral thesis, Università degli studi di Ferrara, 2013. http://hdl.handle.net/11392/2388912.

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It is well established that protein glycosylation, a bioorthogonal process, is a posttranslational modification that profoundly affects protein folding, stability, immunogenicity, and biological properties and activities. In this regard, while native O- and N-glycosidic bonds of glycopeptides are prone to hydrolytic cleavage by O- and N-glycosidases, synthetic C- and S-analogs are expected to be stable toward such enzymatic degradation. Therefore, much effort has been devoted in the last decades to synthesizing C- and S-glycosyl amino acids and their assembly in glycopeptides. They with these

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49

Le, Floch Camille. "Nouvelle méthodologie de synthèse de γ-butyrolactones par une réaction domino métallo-catalysée entre dérivés halogénés, composés carbonylés, et accepteurs de Michael". Thesis, Paris Est, 2011. http://www.theses.fr/2011PEST1098/document.

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Le motif γ-butyrolactone est une entité naturelle très répandue et présente dans de nombreuses molécules à activité biologique. La substitution du cycle à cinq chaînons définit plusieurs classes de composés auxquels les acides paraconiques (portant une fonction acide carboxylique en position β du carbonyle) appartiennent. Ces composés possèdent des activités antitumorales et antibiotiques et représentent une unité structurale intéressante pour la synthèse de molécules à intérêt pharmaceutique. Cependant, la synthèse multicomposant de γ-butyrolactones a été très peu décrite jusqu'à présent. En

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50

Fedou, Nicolas MickaeÃŒl. "Development of a novel isocyanide multicomponent reaction for the generation of highly substituted amides ; : Studies towards the total synthesis of (+)-lactonamycin : investigation of a double Diels-Alder strategy." Thesis, University of Sussex, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441636.

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