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Journal articles on the topic 'Multicomponent reactions (MCRs)'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Reguera, Leslie, Cecilia I. Attorresi, Javier A. Ramírez, and Daniel G. Rivera. "Steroid diversification by multicomponent reactions." Beilstein Journal of Organic Chemistry 15 (June 6, 2019): 1236–56. http://dx.doi.org/10.3762/bjoc.15.121.

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Reports on structural diversification of steroids by means of multicomponent reactions (MCRs) have significantly increased over the last decade. This review covers the most relevant strategies dealing with the use of steroidal substrates in MCRs, including the synthesis of steroidal heterocycles and macrocycles as well as the conjugation of steroids to amino acids, peptides and carbohydrates. We demonstrate that steroids are available with almost all types of MCR reactive functionalities, e.g., carbonyl, carboxylic acid, alkyne, amine, isocyanide, boronic acid, etc., and that steroids are suit

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2

Lee, Daesung, and Sourav Ghorai. "Aryne-Based Multicomponent Coupling Reactions." Synlett 31, no. 08 (2020): 750–71. http://dx.doi.org/10.1055/s-0039-1690824.

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Multicomponent reactions (MCRs) constitute a powerful synthetic tool to generate a large number of small molecules with high atom economy, which thus can efficiently expand the chemical space with molecular diversity and complexity. Aryne-based MCRs offer versatile possibilities to construct functionalized arenes and benzo-fused heterocycles. Because of their electrophilic nature, arynes couple with a broad range of nucleophiles. Thus, a variety of aryne-based MCRs have been developed, the representative of which are summarized in this account.1 Introduction2 Aryne-Based Multicomponent Reactio

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3

Ugi, Ivar. "Recent progress in the chemistry of multicomponent reactions." Pure and Applied Chemistry 73, no. 1 (2001): 187–91. http://dx.doi.org/10.1351/pac200173010187.

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The chemistry of multicomponent reactions (MCRs) and isocyanides belongs to three periods: In the century 18591958, isocyanide chemistry was moderately active and was separate from the classical name reactions of the MCRs. In the next period, isocyanides became well available, and MCRs of isocyanides became the most variable way of forming chemical compounds. The year 1993 began a new era of the formation and investigation of the products and the libraries of the Ugi reaction (U-4CR) and higher MCRs of the isocyanides. This chemistry is primarily accomplished in the industrial search and prep

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4

Bosica, Giovanna, and Roderick Abdilla. "Combination of aza-Friedel Crafts MCR with Other MCRs Under Heterogeneous Conditions." Catalysts 15, no. 7 (2025): 657. https://doi.org/10.3390/catal15070657.

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Multicomponent reactions (MCRs) enable the efficient assembly of complex small molecules via multiple bond-forming events in a single step. However, individual MCRs typically yield products with similar core structures, limiting access to larger, more intricate scaffolds. Strategic selection of reactants allows the combination of distinct MCRs, thus facilitating the synthesis of advanced molecular architectures with potential biological significance. Using our previously reported method for performing the aza-Friedel Crafts multicomponent reaction under green heterogeneous conditions, we have

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5

Koszytkowska-Stawińska, Mariola, and Włodzimierz Buchowicz. "Multicomponent reactions in nucleoside chemistry." Beilstein Journal of Organic Chemistry 10 (July 29, 2014): 1706–32. http://dx.doi.org/10.3762/bjoc.10.179.

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This review covers sixty original publications dealing with the application of multicomponent reactions (MCRs) in the synthesis of novel nucleoside analogs. The reported approaches were employed for modifications of the parent nucleoside core or for de novo construction of a nucleoside scaffold from non-nucleoside substrates. The cited references are grouped according to the usually recognized types of the MCRs. Biochemical properties of the novel nucleoside analogs are also presented (if provided by the authors).

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6

Gulati, Shivani, Stephy Elza John, and Nagula Shankaraiah. "Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects." Beilstein Journal of Organic Chemistry 17 (April 19, 2021): 819–65. http://dx.doi.org/10.3762/bjoc.17.71.

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Microwave-assisted (MWA) multicomponent reactions (MCRs) have successfully emerged as one of the useful tools in the synthesis of biologically relevant heterocycles. These reactions are strategically employed for the generation of a variety of heterocycles along with multiple point diversifications. Over the last few decades classical MCRs such as Ugi, Biginelli, etc. have witnessed enhanced yield and efficiency with microwave assistance. The highlights of MWA-MCRs are high yields, reduced reaction time, selectivity, atom economy and simpler purification techniques, such an approach can accele

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7

Jumbam, Ndze Denis, and Wayiza Masamba. "Bio-Catalysis in Multicomponent Reactions." Molecules 25, no. 24 (2020): 5935. http://dx.doi.org/10.3390/molecules25245935.

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Enzyme catalysis is a very active research area in organic chemistry, because biocatalysts are compatible with and can be adjusted to many reaction conditions, as well as substrates. Their integration in multicomponent reactions (MCRs) allows for simple protocols to be implemented in the diversity-oriented synthesis of complex molecules in chemo-, regio-, stereoselective or even specific modes without the need for the protection/deprotection of functional groups. The application of bio-catalysis in MCRs is therefore a welcome and logical development and is emerging as a unique tool in drug dev

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8

Zhi, Sanjun, Xiaoming Ma, and Wei Zhang. "Consecutive multicomponent reactions for the synthesis of complex molecules." Organic & Biomolecular Chemistry 17, no. 33 (2019): 7632–50. http://dx.doi.org/10.1039/c9ob00772e.

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9

Vavsari, Vaezeh Fathi, Pegah Shakeri, and Saeed Balalaie. "Application of Chiral Isocyanides in Multicomponent Reactions." Current Organic Chemistry 24, no. 2 (2020): 162–83. http://dx.doi.org/10.2174/1385272824666200110095120.

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As one of the most important building blocks in organic synthesis, isocyanides come in for a wide range of transformations owing mostly to their unusual terminal carbon center adsorbed electrophiles, reacted with nucleophiles, get involved in radical reactions and coordinated with metal centers. The distinctive feature of isocyanide is its ready willingness to participate in multicomponent reactions (MCRs). MCRs represent a great tool in organic synthesis for the construction of new lead structures in a single procedure introducing both structural diversity and molecular complexity in only one

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10

Saranya, Salim, K. R. Rohit, Sankaran Radhika, and Gopinathan Anilkumar. "Palladium-catalyzed multicomponent reactions: an overview." Organic & Biomolecular Chemistry 17, no. 35 (2019): 8048–61. http://dx.doi.org/10.1039/c9ob01538h.

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11

Neto, Brenno A. D., Rafael O. Rocha, and Marcelo O. Rodrigues. "Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis." Molecules 27, no. 1 (2021): 132. http://dx.doi.org/10.3390/molecules27010132.

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In this review, we comprehensively describe catalyzed multicomponent reactions (MCRs) and the multiple roles of catalysis combined with key parameters to perform these transformations. Besides improving yields and shortening reaction times, catalysis is vital to achieving greener protocols and to furthering the MCR field of research. Considering that MCRs typically have two or more possible reaction pathways to explain the transformation, catalysis is essential for selecting a reaction route and avoiding byproduct formation. Key parameters, such as temperature, catalyst amounts and reagent qua

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12

Zarganes-Tzitzikas, Tryfon, Ajay L. Chandgude, and Alexander Dömling. "Multicomponent Reactions, Union of MCRs and Beyond." Chemical Record 15, no. 5 (2015): 981–96. http://dx.doi.org/10.1002/tcr.201500201.

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13

Tandi, Mukesh, Vaibhav Sharma, Balasubramanian Gopal, and Sandeep Sundriyal. "Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds." RSC Advances 15, no. 2 (2025): 1447–89. https://doi.org/10.1039/d4ra06681b.

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We have reviewed the recently reported multicomponent reactions (MCRs) yielding cyclic frameworks in a single pot from simple building blocks under mild conditions. These MCRs may prove to be useful for drug discovery projects.

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14

Zadmard, Reza, Ali Akbarzadeh, and Mohammad Reza Jalali. "Highly functionalized calix[4]arenes via multicomponent reactions: synthesis and recognition properties." RSC Advances 9, no. 34 (2019): 19596–605. http://dx.doi.org/10.1039/c9ra03354h.

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Multicomponent reactions (MCRs) include several aspects of green chemistry principles, so it is obvious that chemists in different areas are increasingly interested in providing their product by multicomponent approaches.

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15

Biswas, Swapan Kumar, and Debasis Das. "One-pot Synthesis of Pyrano[2,3-c]pyrazole Derivatives via Multicomponent Reactions (MCRs) and their Applications in Medicinal Chemistry." Mini-Reviews in Organic Chemistry 19, no. 5 (2022): 552–68. http://dx.doi.org/10.2174/1570193x19666211220141622.

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Background: Many pyrano[2,3-c]pyrazole derivatives display diverse biological activities and some of them are known as anticancer, analgesic, anticonvulsant, antimicrobial, antiinflammatory, and anti-malarial agents. In recent years, easy convergent, multicomponent reactions (MCRs) have been adopted to make highly functionalizedpyrano[2,3-c]pyrazole derivatives of biological interest. The synthesis of 1,4-dihydropyrano[2,3-c]pyrazole (1,4-DHPP, 2), 2,4- dihydropyrano[2,3-c]pyrazole (2,4-DHPP, 3), 4-hydroxypyrano[2,3-c]pyrazole (4-HPP, 4) derivatives, 1,4,4-substitied pyranopyrazole (SPP, 5) we

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16

Hurtado-Rodríguez, Diana, Angélica Salinas-Torres, Hugo Rojas, Diana Becerra, and Juan-Carlos Castillo. "Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions." RSC Advances 12, no. 54 (2022): 34965–83. http://dx.doi.org/10.1039/d2ra07056a.

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17

Nunes, Paulo Sérgio Gonçalves, Hérika Danielle Almeida Vidal, and Arlene G. Corrêa. "Recent advances in catalytic enantioselective multicomponent reactions." Organic & Biomolecular Chemistry 18, no. 39 (2020): 7751–73. http://dx.doi.org/10.1039/d0ob01631d.

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Multicomponent reactions have demonstrated a remarkable impact on the synthesis of complex compounds, with high atom economy. In this review, the last decade contributions to enantioselective MCRs by focusing on catalytic approaches are discussed.

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18

Ankita, Chaudhary, Saluja Pooja, Aggarwal Komal, and M. Khurana Jitender. "Applications of acidic and basic TSIL in multicomponent reactions." Journal of Indian Chemical Society Vol. 91, Aug 2014 (2014): 1399–409. https://doi.org/10.5281/zenodo.5728625.

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Department of Chemistry, University of Delhi, Delhi-110 007, India <em>E-mail</em> : jmkhurana1@yahoo.co.in <em>Manuscript received 15 January 2014, accepted 30 January 2014</em> Task specific ionic liquids (TSILs) where a functional group is covalently tethered to the cation or anion (or both) of the ionic liquid, have received increased attention over the last few years. The incorporation of this functionality imbues the ionic liquid with a capacity to behave not only as a reaction medium but also as a catalyst in some reactions. The development of new ecocompatible green methodologies and n

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19

Alsolami, Eman S., Hajar S. Alorfi, Khalid A. Alamry, and Mahmoud A. Hussein. "One-pot multicomponent polymerization towards heterocyclic polymers: a mini review." RSC Advances 14, no. 3 (2024): 1757–81. http://dx.doi.org/10.1039/d3ra07278a.

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Multicomponent polymerization (MCP) is an innovative field related to polymer-based chemistry that offers numerous advantages derived from multicomponent reactions (MCRs). One of the key advantages of MCP is its ability to achieve high efficiency.

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20

Patel, Dhaval B., Jagruti A. Parmar, Siddharth S. Patel, Unnati J. Naik, and Hitesh D. Patel. "Recent Advances in Ester Synthesis by Multi-Component Reactions (MCRs): A Review." Current Organic Chemistry 25, no. 5 (2021): 539–53. http://dx.doi.org/10.2174/1385272825666210111111805.

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The synthesis of ester-containing heterocyclic compounds via multicomponent reaction is one of the preferable processes in synthetic organic chemistry and medicinal chemistry. Compounds containing ester linkage have a wide range of biological applications in the pharmaceutical field. Therefore, many methods have been developed for the synthesis of these types of derivatives. However, some of them are carried out in the presence of toxic solvents and catalysts, with lower yields, longer reaction times, low selectivities, and byproducts. Thus, the development of new synthetic methods for ester s

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21

Zhao, Yuan, Bin Yang, Chongyu Zhu, et al. "Introducing mercaptoacetic acid locking imine reaction into polymer chemistry as a green click reaction." Polym. Chem. 5, no. 8 (2014): 2695–99. http://dx.doi.org/10.1039/c4py00058g.

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Some multicomponent reactions (MCRs) are similar to click reactions to give highly selective products with reliable high yield and effective atom utilization, implying that they can also be recognized as click reactions.

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22

Insuasty, Daniel, Juan Castillo, Diana Becerra, Hugo Rojas, and Rodrigo Abonia. "Synthesis of Biologically Active Molecules through Multicomponent Reactions." Molecules 25, no. 3 (2020): 505. http://dx.doi.org/10.3390/molecules25030505.

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Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should be obtained via a multicomponent reaction; (2) the reported products should be biologically actives or at

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23

Ravindran, Jaice, Velickakathu O. Yadhukrishnan, Reghuvaran S. Asha, and Ravi S. Lankalapalli. "Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by DDQ." Organic & Biomolecular Chemistry 18, no. 20 (2020): 3927–37. http://dx.doi.org/10.1039/d0ob00721h.

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24

Graebin, Cedric S., Felipe V. Ribeiro, Kamilla R. Rogério, and Arthur E. Kümmerle. "Multicomponent Reactions for the Synthesis of Bioactive Compounds: A Review." Current Organic Synthesis 16, no. 6 (2019): 855–99. http://dx.doi.org/10.2174/1570179416666190718153703.

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Multicomponent reactions (MCRs) are composed of three or more reagents in which the final product has all or most of the carbon atoms from its starting materials. These reactions represent, in the medicinal chemistry context, great potential in the research for new bioactive compounds, since their products can present great structural complexity. The aim of this review is to present the main multicomponent reactions since the original report by Strecker in 1850 from nowadays, covering their evolution, highlighting their significance in the discovery of new bioactive compounds. The use of MCRs

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25

Xu, Chuan, Zhong-Zhu Chen, Zhi-Gang Xu, et al. "Facile Construction of Hydantoin Scaffolds via a Post-Ugi Cascade Reaction." Synlett 29, no. 16 (2018): 2199–202. http://dx.doi.org/10.1055/s-0037-1610234.

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A small series of hydantoins was efficiently synthesized via a two-step Ugi/cyclization reaction sequence using alkyne group as a leaving group under basic conditions. This microwave-assisted one-pot cyclization strategy could be applicable to other multicomponent reactions (MCRs) for synthesizing bioactive and drug-like hydantoins.

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26

Ramos, Luciana M., Marcelo O. Rodrigues, and Brenno A. D. Neto. "Mechanistic knowledge and noncovalent interactions as the key features for enantioselective catalysed multicomponent reactions: a critical review." Organic & Biomolecular Chemistry 17, no. 31 (2019): 7260–69. http://dx.doi.org/10.1039/c9ob01088b.

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27

Abou-Shehada, S., P. Mampuys, B. U. W. Maes, J. H. Clark, and L. Summerton. "An evaluation of credentials of a multicomponent reaction for the synthesis of isothioureas through the use of a holistic CHEM21 green metrics toolkit." Green Chemistry 19, no. 1 (2017): 249–58. http://dx.doi.org/10.1039/c6gc01928e.

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Multicomponent reactions (MCRs) are considered green and material efficient methods for the synthesis of organic compounds, however very few studies have investigated the metrics of the upstream processes involved to achieve the starting materials used in these reactions.

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28

Patil, Vishvanath D., Amruta M. Salve, V. D. Gharat, and N. Gawand. "Multicomponent one pot synthesis of Substituted 3,4-Dihydropyrimidin-2-(1H)-ones by Nanocrystalline CeO2." Research Journal of Chemistry and Environment 25, no. 8 (2022): 83–89. http://dx.doi.org/10.25303/258rjce8389.

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One of the most prominent multicomponent reactions (MCRs), Biginelli reaction has been utilized for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones catalyzed one-pot condensation of aldehyde, β- ketoester and urea in presence of ethanol. The present study deals with synthesis of biologically active 3, 4- dihydropyrimidin-2(1H)-ones using nano crystalline CeO2.

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29

Salem, Mohammed A., Moustafa A. Gouda, and Ghada G. El-Bana. "Chemistry of 2-(Piperazin-1-yl) Quinoline-3-Carbaldehydes." Mini-Reviews in Organic Chemistry 19, no. 4 (2022): 480–95. http://dx.doi.org/10.2174/1570193x18666211001124510.

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Abstract: This review described the preparation of 2- chloroquinoline-3-carbaldehyde derivatives 18 through Vilsmeier-Haack formylation of N-arylacetamides and the use of them as a key intermediate for the preparation of 2-(piperazin-1-yl) quinoline-3-carbaldehydes. The synthesis of the 2- (piperazin-1-yl) quinolines derivatives was explained through the following chemical reactions: acylation, sulfonylation, Claisen-Schmidt condensation, 1, 3-dipolar cycloaddition, one-pot multicomponent reactions (MCRs), reductive amination, Grignard reaction and Kabachnik-Field’s reaction.

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30

Singh, M. S., and Pratibha Singh. "Multicomponent Reactions (MCRs) Leading to Silaheterocycles via Dianion Cyclization." Phosphorus, Sulfur, and Silicon and the Related Elements 182, no. 4 (2007): 835–43. http://dx.doi.org/10.1080/10426500601061991.

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31

Zarganes-Tzitzikas, Tryfon, Ajay L. Chandgude, and Alexander Doemling. "ChemInform Abstract: Multicomponent Reactions, Union of MCRs and Beyond." ChemInform 46, no. 52 (2015): no. http://dx.doi.org/10.1002/chin.201552205.

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32

Haji, Mohammad. "Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates." Beilstein Journal of Organic Chemistry 12 (June 21, 2016): 1269–301. http://dx.doi.org/10.3762/bjoc.12.121.

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Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

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33

da Silva, Allan, Deborah dos Santos, Marcio Paixão, and Arlene Corrêa. "Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines." Molecules 24, no. 3 (2019): 630. http://dx.doi.org/10.3390/molecules24030630.

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Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines

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34

Benzenine, Djamila, Zahira Kibou, Fatima Belhadj, et al. "Efficient Multicomponent Catalyst-Free Synthesis of Substituted 2-Aminopyridines." Chemistry Proceedings 3, no. 1 (2020): 125. http://dx.doi.org/10.3390/ecsoc-24-08381.

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2-aminopyridines scaffolds are an important class of nitrogen heterocyclic compounds with a wide range of biological activities. Multicomponent reactions (MCRs) are useful methods for the construction of nitrogen heterocyclic compounds. In this context, syntheses of 2-aminopyridines derivatives via MCRs have attracted considerable attention in recent years. We present, in this work, a rapid and efficient synthesis of 2-aminopyridine derivatives, via the catalyst-free four-component method. This protocol provides a simple and practical approach to functionalized 2-aminopyridnes from readily ava

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35

Huh, Daniel N., Yukun Cheng, Connor W. Frye, Dominic T. Egger, and Ian A. Tonks. "Multicomponent syntheses of 5- and 6-membered aromatic heterocycles using group 4–8 transition metal catalysts." Chemical Science 12, no. 28 (2021): 9574–90. http://dx.doi.org/10.1039/d1sc03037j.

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In this Perspective, we discuss recent syntheses of 5- and 6-membered aromatic heterocycles via multicomponent reactions (MCRs) catalyzed by group 4–8 transition metals, with a focus on common mechanisms and synthetic strategies across the series.

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36

Hooshmand, Seyyed Emad, and Wei Zhang. "Ugi Four-Component Reactions Using Alternative Reactants." Molecules 28, no. 4 (2023): 1642. http://dx.doi.org/10.3390/molecules28041642.

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The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent multicomponent reaction (MCRs) that has sparked organic chemists’ interest in the field. It has been widely used in the synthesis of diverse heterocycle molecules such as potential drugs, natural product analogs, pseudo peptides, macrocycles, and functional materials. The Ugi-4CRs involve the use of an amine, an aldehyde or ketone, an isocyanide, and a carboxylic acid to produce an α-acetamido carboxamide derivative, which has significantly advanced the field of isocyanide-based MCRs. The so-called intermediate nitrili

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37

Ma, Xiaoming, Sanjun Zhi, and Wei Zhang. "Recent Developments on Five-Component Reactions." Molecules 26, no. 7 (2021): 1986. http://dx.doi.org/10.3390/molecules26071986.

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Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.

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38

Bosica, Giovanna, and Roderick Abdilla. "Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions." Catalysts 12, no. 7 (2022): 725. http://dx.doi.org/10.3390/catal12070725.

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Multicomponent reactions (MCRs) have been gaining significance and attention over the past decade because of their ability to furnish complex products by using readily available and simple starting materials while simultaneously eliminating the need to separate and purify any intermediates. More so, most of these products have been found to exhibit diverse biological activities. Another paradigm shift which has occurred contemporarily is the switch to heterogeneous catalysis, which results in additional benefits such as the reduction of waste and an increase in the safety of the process. More

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39

Yuan, Rui, Xianzhe He, Chongyu Zhu, and Lei Tao. "Recent Developments in Functional Polymers via the Kabachnik–Fields Reaction: The State of the Art." Molecules 29, no. 3 (2024): 727. http://dx.doi.org/10.3390/molecules29030727.

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Recently, multicomponent reactions (MCRs) have attracted much attention in polymer synthesis. As one of the most well-known MCRs, the Kabachnik–Fields (KF) reaction has been widely used in the development of new functional polymers. The KF reaction can efficiently introduce functional groups into polymer structures; thus, polymers prepared via the KF reaction have unique α-aminophosphonates and show important bioactivity, metal chelating abilities, and flame-retardant properties. In this mini-review, we mainly summarize the latest advances in the KF reaction to synthesize functional polymers f

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40

Ma, Zeyu, Bo Wang, and Lei Tao. "Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction." Molecules 27, no. 22 (2022): 7886. http://dx.doi.org/10.3390/molecules27227886.

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Multicomponent reactions (MCRs) have been used to prepare polymers with appealing functions. The Biginelli reaction, one of the oldest and most famous MCRs, has sparked new scientific discoveries in polymer chemistry since 2013. Recent years have seen the Biginelli reaction stepping further from simple coupling tools; for example, the functions of the Biginelli product 3,4-dihydropyrimidin-2(1H)-(thi)ones (DHPM(T)) have been gradually exploited to develop new functional polymers. In this mini-review, we mainly summarize the recent progress of using the Biginelli reaction to identify polymers f

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41

Heravi, Majid M., and Vahideh Zadsirjan. "Recent Advances in Biginelli-type Reactions." Current Organic Chemistry 24, no. 12 (2020): 1331–66. http://dx.doi.org/10.2174/1385272824999200616111228.

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The effective and high yielding synthesis of poly-functionalized pyrimidines, using multicomponent reactions (MCRs), is imperative in organic and medicinal chemistry. The classic Biginelli reaction is a typically one-pot three-component cyclocondensation reaction involving an aldehyde, a &#946;-ketoester and urea, resulting in the construction of multi-functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs). In recent years, other active methylene compounds, various derivatives of urea and diversely substituted aldehydes have also been used, resulting in the preparation of a new series of v

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Graziano, Giovanni, Angela Stefanachi, Marialessandra Contino, et al. "Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs." International Journal of Molecular Sciences 24, no. 7 (2023): 6581. http://dx.doi.org/10.3390/ijms24076581.

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Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications in drug discovery and development. MCRs are flexible transformations in which three or more substrates react to form structurally complex products with high atomic efficiency. They are being increasingly appreciated as a highly exploratory and evolutionary tool by the medicinal chemistry community, opening the door to more sustainable, cost-effective and rapid synthesis of biologically active molecules. In recent years, MCR-based synthetic strategies have foun

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Neto, Brenno A. D., Pedro S. Beck, Jenny E. P. Sorto, and Marcos N. Eberlin. "In Melting Points We Trust: A Review on the Misguiding Characterization of Multicomponent Reactions Adducts and Intermediates." Molecules 27, no. 21 (2022): 7552. http://dx.doi.org/10.3390/molecules27217552.

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We discuss herein the problems associated with using melting points to characterize multicomponent reactions’ (MCRs) products and intermediates. Although surprising, it is not rare to find articles in which these MCRs final adducts (or their intermediates) are characterized solely by comparing melting points with those available from other reports. A brief survey among specialized articles highlights serious and obvious problems with this practice since, for instance, cases are found in which as many as 25 quite contrasting melting points have been attributed to the very same MCR adduct. Indee

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Jiang, Xuefeng, and Minghao Feng. "Reactions of Arynes Involving Transition-Metal Catalysis." Synthesis 28, no. 19 (2017): 4414–33. http://dx.doi.org/10.1055/s-0036-1589094.

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Arynes are important building blocks for introducing aromatic rings into molecules and they are frequently utilized in syntheses. Historically, arynes were generated under harsh conditions and this limited their use. Arynes can now be generated under milder conditions, e.g. from 2-(trimethylsilyl)phenyl triflate, and utilized in transition-metal catalyzed reactions such as [2+2+2] reactions, insertion into σ-bonds, cascade cyclizations and C–H activation reactions. This short review focuses on transition-metal-catalyzed reactions relevant to aryne intermediates generated from 2-(trimethylsily

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de Marigorta, Edorta Martínez, Jesús M. de Los Santos, Ana M. Ochoa de Retana, Javier Vicario та Francisco Palacios. "Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams". Beilstein Journal of Organic Chemistry 15 (8 травня 2019): 1065–85. http://dx.doi.org/10.3762/bjoc.15.104.

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Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the structure of many pharmaceutically active molecules. They can be often synthesized by means of multicomponent approaches and recent contributions in this field are summarized in this review. Clear advantages of these methods include the efficiency in saving raw materials and working time. However, there is still a need of new catalytic systems to allow the enantioselective preparation of these heterocycles by multicomponent reactions.

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Koopmanschap, Gijs, Eelco Ruijter, and Romano VA Orru. "Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics." Beilstein Journal of Organic Chemistry 10 (March 4, 2014): 544–98. http://dx.doi.org/10.3762/bjoc.10.50.

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In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certain receptor. Moreover, these cyclic mimics force the molecule into a well-defined secondary structure. Constraint structural and conformational features are often found in biological active peptides. For

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Brandão, Pedro, Carolina S. Marques, Elisabete P. Carreiro, M. Pineiro, and Anthony J. Burke. "Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity." Chemical Record 21, no. 4 (2021): 924–1037. http://dx.doi.org/10.1002/tcr.202000167.

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Choudhury, Lokman H., and Tasneem Parvin. "Recent advances in the chemistry of imine-based multicomponent reactions (MCRs)." Tetrahedron 67, no. 43 (2011): 8213–28. http://dx.doi.org/10.1016/j.tet.2011.07.020.

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Zhao, Hua, and Yufen Zhao. "Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity." Molecules 28, no. 18 (2023): 6488. http://dx.doi.org/10.3390/molecules28186488.

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Multicomponent reactions (MCRs) have undoubtedly emerged as the most indispensable tool for organic chemists worldwide, finding extensive utility in the synthesis of intricate natural products, heterocyclic molecules with significant bioactivity, and pharmaceutical agents. The multicomponent one-pot 1,3-dipolar cycloaddition reactions, which were initially conceptualized by Rolf Huisgen in 1960, find extensive application in contemporary heterocyclic chemistry. In terms of green synthesis, the multicomponent 1,3-dipolar cycloaddition is highly favored owing to its numerous advantages, includin

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Messire, Gatien, Emma Caillet, and Sabine Berteina-Raboin. "Green Catalysts and/or Green Solvents for Sustainable Multi-Component Reactions." Catalysts 14, no. 9 (2024): 593. http://dx.doi.org/10.3390/catal14090593.

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Here, we describe some well-known multicomponent reactions and the progress made over the past decade to make these processes even more environmentally friendly. We focus on the Mannich, Hantzsch, Biginelli, Ugi, Passerini, Petasis, and Groebke–Blackburn–Bienaymé reactions. After describing the origin of the reactions and their mechanisms, we summarize some advances in terms of the eco-compatibility of these different MCRs. These are followed by examples of some reactions, considered as variants, which are less well documented but which are promising in terms of structures generated or synthet

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