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Journal articles on the topic 'Multidrug resistant tuberculosis (MDR-TB)'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Paul, Rajput, Singh, and Bera. "A Case Series Study to Assess the Clinical and Socio Demographic Aspects of MDR TB Clients Admitted in Selected Hospitals of Indore." International Journal of Research Publication and Reviews 3, no. 12 (2022): 1656–57. https://doi.org/10.5281/zenodo.7472019.

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The World Health Organization (WHO) defines multidrug-resistant tuberculosis (MDR-TB) as resistance to isoniazid and rifampicin, with or without resistance to other anti-tuberculosis drugs. MDR-TB is a subtype of multidrug-resistant tuberculosis (MDR-TB). It is becoming a significant concern for human health on a global basis, and it presents a threat to the efforts being made to control tuberculosis. According to the most recent statistics on the monitoring of anti-TB drug resistance, it is estimated that 4.3% of newly diagnosed cases and 18% of previously treated cases of tuberculosis across

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2

Nwachukwu, Ndubuisi O., Amara E. Ulasi, Christopher U. Okoronkwo, and Valentine N. Unegbu. "Pre-extensively drug-resistant tuberculosis among pulmonary multidrug-resistant tuberculosis patients in Eastern Nigeria." Lung India 40, no. 6 (2023): 492–95. http://dx.doi.org/10.4103/lungindia.lungindia_337_23.

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Background: Pre-extensively drug-resistant tuberculosis (Pre-XDR-TB), an emerging form of drug-resistant tuberculosis, is challenging efforts at tuberculosis control, leading to treatment failure among multidrug-resistant tuberculosis (MDR-TB) patients and progression to extensively drug-resistant tuberculosis (XDR-TB). We determined the rate of Pre-XDR-TB among multidrug-resistant patients in Southeast, Nigeria. Methods: A prospective laboratory-based study was carried out at the South East Zonal Tuberculosis Reference Laboratory from January 2021 to December 2021. Second-line drug (SLD) resi

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Caminero, Jose, and Charles Daley. "Management of Multidrug-Resistant Tuberculosis." Seminars in Respiratory and Critical Care Medicine 39, no. 03 (2018): 310–24. http://dx.doi.org/10.1055/s-0038-1661383.

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AbstractDrug-resistant strains of Mycobacterium tuberculosis pose a major threat to global tuberculosis control. Despite the availability of curative antituberculosis therapy for nearly half a century, inappropriate and inadequate treatment of tuberculosis, as well as unchecked transmission of M. tuberculosis, has resulted in alarming levels of drug-resistant tuberculosis. The World Health Organization (WHO) estimates that there were 600,000 cases of multidrug-resistant tuberculosis (MDR-TB)/rifampin-resistant (RR) tuberculosis in 2016, defined as strains that are resistant to at least isoniaz

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4

Mashidayanti, Aulia, Nurlely Nurlely, and Nani Kartinah. "Faktor Risiko Yang Berpengaruh Pada Kejadian Tuberkulosis dengan Multidrug-Resistant Tuberculosis (MDR-TB) di RSUD Ulin Banjarmasin." Jurnal Pharmascience 7, no. 2 (2020): 139. http://dx.doi.org/10.20527/jps.v7i2.7928.

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MDR-TB (Multidrug-Resistant Tuberculosis) adalah salah satu jenis TB yang resisten dengan OAT (Obat Anti Tuberculosis) dengan resisten terhadap 2 obat anti tuberculosis yang paling ampuh yaitu rifampisin dan isoniazid. Obat rifampisin dan isoniazid sudah tidak efektif dalam membunuh kuman mycobacterium tuberkulosis dikarenakan kuman yang sudah resisten terhadap obat tersebut. MDR-TB merupakan suatu permasalahan yang menjadi hambatan utama dunia dalam pemberantasan TB. Tujuan dari penelitian ini adalah untuk mengidentifikasi faktor risiko apa saja yang dapat berpengaruh pada kejadian tuberkulos

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5

Paudel, Sita. "Risk Factors of Multidrug-Resistant Tuberculosis." International Journal of Applied Sciences and Biotechnology 5, no. 4 (2017): 548–54. http://dx.doi.org/10.3126/ijasbt.v5i4.18771.

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Multidrug-resistant tuberculosis has been increased worldwide which is a severe problem. A case-control study was carried out among 50 MDR-TB cases and 63 drug susceptible controls to identify risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Lumbini Zone. Irregularity in taking medicine (OR=2.36), large family size (OR=2.40), farming as occupation (OR=2.83), history of TB and bovine at home (OR=6.5) were statistically associated with MDR-TB. Most of the MDR-TB cases were males (82%) and individual with the age group 21-30 years (40%) were highly infected with MDR-TBInt

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Yulianti, Yulianti, and Sally Mahdiani. "Gangguan pendengaran penderita Tuberkulosis Multidrug Resistant." Oto Rhino Laryngologica Indonesiana 45, no. 2 (2015): 83. http://dx.doi.org/10.32637/orli.v45i2.112.

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Latar belakang: Tuberkulosis Multidrug Resistant (TB MDR) merupakan penyakit tuberkulosis (TB) yang resisten terhadap isoniazid dan rifampisin, dengan atau tanpa resisten terhadap obat anti- TB lain. Terapi aminoglikosida pada TB MDR berisiko untuk terjadinya gangguan fungsi telinga dan sistem keseimbangan tubuh, yang dapat bersifat irreversible atau permanen. Kerusakan pada koklea dapat menimbulkan penurunan pendengaran permanen. Tujuan: Mengetahui gangguan pendengaran penderita TB MDR di poliklinik TB MDR Ilmu Penyakit Dalam RS Hasan Sadikin Bandung. Metode: Penelitian deskriptif secara retr

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7

Huang, Huai, Yu-Shuai Han, Jing Chen, et al. "The novel potential biomarkers for multidrug-resistance tuberculosis using UPLC-Q-TOF-MS." Experimental Biology and Medicine 245, no. 6 (2020): 501–11. http://dx.doi.org/10.1177/1535370220903464.

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The lack of rapid and efficient diagnostics impedes largely the epidemic control of multidrug-resistant tuberculosis, and might misguide the therapeutic strategies as well. This study aimed to identify novel multidrug-resistant tuberculosis biomarkers to improve the early intervention, symptomatic treatment and control of the prevalence of multidrug-resistant tuberculosis. The serum small molecule metabolites in healthy controls, patients with drug-susceptible tuberculosis, and patients with multidrug-resistant tuberculosis were screened using ultra-high-performance liquid chromatography combi

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8

Rozi, Fahrur, Fakhrun Nisa’ Fiddaroini, and Prawito Prawito. "AGE, GENDER, EDUCATIONAL LEVEL, OCCUPATIONAL, AND KNOWLEDGE LEVEL ABOUT MULTIDRUG RESISTANT TUBERCULOSIS (MDR-TB) AMONG TUBERCULOSIS PATIENTS." Nurse and Holistic Care 3, no. 1 (2023): 39–46. http://dx.doi.org/10.33086/nhc.v3i1.4603.

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Background: Resistance of Mycobacterium Tuberculosis is a condition in which Anti-Tuberculosis (OAT) drugs are unable to kill the Mycobacterium Tuberculosis germs. One type of resistance is Multidrug Resistant Tuberculosis. Multidrug Resistant Tuberculosis (MDR-TB) is TB caused by TB bacteria that are resistant to 2 types of OAT, namely INH and Rifampin. The consequences if resistance to OAT are deterioration of health, increased costs, prolonged treatment, high rates of therapy failure and death. Objective: This study aimed to determine relationship between age, gender, educational leve

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Li, Yingying, Yifan Li, Tingting Wang, et al. "Multidrug-resistant Mycobacterium tuberculosis transmission in Shandong, China." Medicine 103, no. 12 (2024): e37617. http://dx.doi.org/10.1097/md.0000000000037617.

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Multidrug-resistant tuberculosis (MDR-TB) has imposed a significant economic and health burden worldwide, notably in China. Using whole genome sequence, we sought to understand the mutation and transmission of MDR-TB in Shandong. A retrospective study of patients diagnosed with pulmonary tuberculosis in Shandong from 2009 to 2018 was conducted. To explore transmission patterns, we performed whole genome sequencing on MDR-TB isolates, identified genomic clusters, and assessed the drug resistance of TB isolates. Our study analyzed 167 isolates of MDR-TB, finding that 100 were clustered. The pred

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Soesanti, Soesanti, and Abd Hakim Husen. "ANALISIS FAKTOR DETERMINAN DEMOGRAFI DENGAN KEJADIAN TUBERCULOSIS MULTIDRUG RESISTANT TUBERCULOSIS (MDR-TB)." NURSING UPDATE : Jurnal Ilmiah Ilmu Keperawatan P-ISSN : 2085-5931 e-ISSN : 2623-2871 13, no. 2 (2022): 43–47. http://dx.doi.org/10.36089/nu.v13i2.730.

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Tuberculosis (TB) is one of the top 10 causes of death worldwide. Multidrug Resistant Tuberculosis (MDR-TB) is TB that is drug resistant to at least 2 (two) most potent anti-TB drugs. This study aims to determine the relationship between age and sex factors with the incidence of Multidrug Resistant Tuberculosis (MDR-TB). This cross-sectional study involved 37 people with pulmonary tuberculosis in the 2019-2021 period which was carried out in the work area of the Ternate City Health Office. Data analysis using chi square test. The results showed that the characteristics of MDR-TB patients in

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Khurram, Muhammad, Hamama Tul Bushra Khaar, and Muhammad Fahim. "Multidrug-resistant tuberculosis in Rawalpindi, Pakistan." Journal of Infection in Developing Countries 6, no. 01 (2011): 29–32. http://dx.doi.org/10.3855/jidc.1738.

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Introduction: Multidrug-resistant (MDR) tuberculosis (TB) strains are resistant to isoniazid and rifampicin. Clinical characteristics, drug susceptibility patterns, and outcomes of MDR-TB patients treated at Holy Family Hospital, Rawalpindi, Pakistan, were studied from January 2007 to April 2010. Methodology: Thirty diagnosed patients (60% male and 40% female) of MDR pulmonary TB were included. Each patient was treated according to WHO guidelines and followed for two years. Clinical characteristics (age, gender, literate or illiterate educational status, employment status, and income), drug su

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Burhan, Siti Latifah, Wahiduddin Wahiduddin, Ida Leida Maria, M. Nadjib Bustan, Lalu Muhammad Saleh, and Balqis Balqis. "Multidrug resistant tuberculosis risk factors in Makassar, Indonesia." International Journal of Public Health Science (IJPHS) 13, no. 4 (2025): 1656–63. https://doi.org/10.11591/ijphs.v13i4.24753.

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Multidrug resistant tuberculosis (MDR-TB) is a significant public health concern in Indonesia, resulting in substantial morbidity and mortality rates. This study aimed to quantify the impact of risk factors of MDR-TB. A case-control study was conducted at Makassar Community Lung Health Center (BBKPM) in Makassar City. A total of 132 respondents, 66 cases, and 66 controls have participated in the study. Data was analyzed using the Stata version 14 tool, odds ratio (OR), and multiple logistic regression. Multiple logistic regression analysis identified significant risk factors for the occurrence

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13

Subairi, Moh, Abdul Muhith, and Chilyatiz Zahro. "Multidrug Resistant Tuberculosis (MDR-TB) Factors: Literature Review." Journal of Applied Nursing and Health 5, no. 2 (2023): 233–44. http://dx.doi.org/10.55018/janh.v5i2.154.

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Background: Multidrug-resistant tuberculosis (MDRTB) is the biggest problem in preventing and eradicating TB in the world. MDR-TB occurs if the tuberculosis germs are resistant to various first-line OAT, at least two drugs, namely isoniazid and rifampicin. The emergence of MDR-TB cases presents new obstacles and challenges to the effectiveness of TB control programs due to difficult diagnosis, high rates of therapy failure, and death. This literature review aims to determine the factors that cause multidrug-resistant tuberculosis (MDR-TB). Methods: The method used in this article is a literatu

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14

Gobaud, A. N., C. A. Haley, J. W. Wilson, et al. "Multidrug-resistant tuberculosis care in the United States." International Journal of Tuberculosis and Lung Disease 24, no. 4 (2020): 409–13. http://dx.doi.org/10.5588/ijtld.19.0515.

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BACKGROUND: To examine the utilization of the Tuberculosis (TB) Centers of Excellence (COE) medical consultation service and evaluate how these services were being employed for patients in relation to multidrug-resistant TB (MDR-TB).METHODS: Medical consults are documented in a secure database. The database was queried for MDR-TB consultations over the period 1 January 2013–31 December 2017. All were analyzed to assess provider type, center, setting, year of call, and type of patient (pediatric vs. adult). A subgroup was randomly selected for thematic analysis.RESULTS: The centers received 156

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Butov, D., C. Lange, J. Heyckendorf, et al. "Multidrug-resistant tuberculosis in the Kharkiv Region, Ukraine." International Journal of Tuberculosis and Lung Disease 24, no. 5 (2020): 485–91. http://dx.doi.org/10.5588/ijtld.19.0508.

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OBJECTIVE: To document the level of drug resistance in MDR-TB patients and to characterize management capacities for their medical care and MDR-TB treatment outcomes in the Kharkiv region of Ukraine. This area has one of the highest frequencies of MDR-TB worldwide.METHODS: A retrospective observational cohort study was performed on registry data from the regional anti-TB dispensary in Kharkiv. All microbiologically confirmed MDR-TB patients registered in 2014 were included. Diagnostic, treatment and post-treatment follow-up data were analysed.RESULTS: Of 169 patients with MDR-TB, 55.0% had pre

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Azwar, Gusti Andhika, Dewi Indah Noviana, and FX Hendriyono. "KARAKTERISTIK PENDERITA TUBERKULOSIS PARU DENGAN MULTIDRUG-RESISTANT TUBERCULOSIS (MDR-TB) DI RSUD ULIN BANJARMASIN." Berkala Kedokteran 13, no. 1 (2017): 23. http://dx.doi.org/10.20527/jbk.v13i1.3436.

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Abstract: Tuberculosis is the main health problem in the world and getting worse with Multidrug-Resistant Tuberculosis (MDR-TB) cases. Many research about MDR-TB patients is conducted to describe MDR-TB patients characteristics. This research aims to describe the characteristics of pulmonary tuberculosis MDR-TB at RSUD Ulin Banjarmasin on December 2015-May 2016. This was a descriptive research with crossectional approaches. Data were collected from clinical pathology laboratory and patients medical record. The Result indicate that as many as 19 pulmonary TB patients with MDR-TB at RSUD Ulin Ba

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P.Pravalika, G.Akhila, M.Himabindhu, and K.Hemanth. "A REVIEW ON PHARMACOTHERAPY FOR MULTIDRUG RESISTANCE TUBERCULOSIS." International Journal of Scientific Development and Research 9, no. 4 (2024): 1262–70. https://doi.org/10.5281/zenodo.11239565.

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Multidrug-resistant tuberculosis (MDR-TB) is a critical global health challenge characterized by bacterial strains of Mycobacterium tuberculosis that have developed resistance to at least two key first-line anti-TB drugs, isoniazid, and rifampicin. The emergence of MDR-TB is primarily attributed to factors such as inadequate treatment regimens, poor patient adherence, and suboptimal healthcare systems. This form of drug resistance not only complicates treatment efforts but also raises concerns about prolonged therapy, increased healthcare costs, and the potential for treatment failure. In more

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Muthia Rakha Yasyfa, Fajar Awalia Yulianto, and Raden Ganang Ibnusantosa. "Studi Literatur: Faktor Risiko Multidrug-Resistant Tuberculosis pada Anak." Bandung Conference Series: Medical Science 5, no. 1 (2025): 233–40. https://doi.org/10.29313/bcsms.v5i1.16404.

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Abstract. Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis and poses a significant global health issue. This study aims to explore the incidence of Multidrug-Resistant Tuberculosis (MDR-TB) in children, as well as the risk factors contributing to its prevalence. The methodology employed is a literature review, with data collection conducted through library searches via EBSCOhost and manual web searches using the search keywords “multidrug-resistant” AND “children” to obtain articles containing both keywords, and “multidrug-resistant” OR “MDR-TB” to broaden the sea

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Baiq Ayu Rahmawati and Rina Lestari. "Tuberkulosis Multidrug-Resistant (TB-MDR): Diagnosis and Treatment." Lombok Medical Journal 3, no. 2 (2024): 38–43. https://doi.org/10.29303/lmj.v3i2.3223.

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Multidrug-Resistant Tuberculosis (MDR-TB) is a TB disease that is resistant to rifampicin and isoniazid with or without other first-line Anti-Tuberculosis Drugs (OAT). Accurate MDR-TB diagnosis and treatment methods are very important to minimize the impact of the disease. The aim of this literature review is to increase understanding of MDR-TB, with a focus on discussing methods of diagnosing and treating MDR-TB. Diagnosis in MDR-TB patients can be done using TCM and sensitivity testing using the Line-2 LPA (Line Probe Assay) method or conventional methods. Treatment is in the form of the use

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Burhan, Siti Latifah, Wahiduddin Wahiduddin, Ida Leida Maria, M. Nadjib Bustan, Lalu Muhammad Saleh, and Balqis Balqis. "Multidrug resistant tuberculosis risk factors in Makassar, Indonesia." International Journal of Public Health Science (IJPHS) 13, no. 4 (2024): 1656. http://dx.doi.org/10.11591/ijphs.v13i4.24753.

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Multidrug resistant tuberculosis (MDR-TB) is a significant public health concern in Indonesia, resulting in substantial morbidity and mortality rates. This study aimed to quantify the impact of risk factors of MDR-TB. A case-control study was conducted at Makassar Community Lung Health Center (BBKPM) in Makassar City. A total of 132 respondents, 66 cases, and 66 controls have participated in the study. Data was analyzed using the Stata version 14 tool, odds ratio (OR), and multiple logistic regression. Multiple logistic regression analysis identified significant risk factors for the occurrence

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Datta, Bikram Singh, Ghulam Hassan, Syed Manzoor Kadri, et al. "Multidrug-Resistant and Extensively Drug Resistant Tuberculosis in Kashmir, India." Journal of Infection in Developing Countries 4, no. 01 (2009): 019–23. http://dx.doi.org/10.3855/jidc.669.

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Background: To study the profile of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in tertiary care hospital setting, representing almost the whole affected population in Kashmir valley of India. Methodology: A total of 910 cases of pulmonary tuberculosis were enrolled over four years. Among these, cases of MDR-TB and XDR-TB were meticulously studied for drug susceptibility, treatment, adverse effects profile and overall survival. Results: Fifty-two (5.7%) cases of MDR-TB were identified, among which eight (15.3%) were diagnosed as XDR-TB on the

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Samper, S., M. J. Iglesias, and O. Tello. "The Spanish multidrug resistant tuberculosis network." Eurosurveillance 5, no. 4 (2000): 43–45. http://dx.doi.org/10.2807/esm.05.04.00037-en.

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The network to monitor the spread of multidrug resistance tuberculosis (MDR-TB) in Spain based on genomic typing and set up in January 1998 benefits from the participation of about 90% of the laboratories of the national health system. Of the 94 MDR-TB pa

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Husada, M. Surya, Bahagia Loebis, and Ariwan Selian. "Total Score Differences of Hospital Anxiety and Depression Scale – Depression (HADS-D) in Patients with Multidrug-Resistant Tuberculosis (MDR-TB) Based on Gender at H. Adam Malik General Hospital Medan." Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences 4, no. 1 (2021): 1461–66. http://dx.doi.org/10.33258/birci.v4i1.1774.

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Tuberculosis (TB) is a contagious and airborne disease. Over the decades, psychiatric morbidity in patients with MDR-TB has become increasingly recognized. Resistant tuberculosis is currently a serious health problem worldwide. This chronic disease takes a long time and causes various side effects, often causing symptoms of depression and anxiety in patients with Multidrug-resistant tuberculosis (MDR-TB) and pulmonary tuberculosis (TB). However, there are still relatively few who focus on psychiatric disorders in patients with MDR-TB. To find out the total score differences of Hospital Anxiety

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Wulandari, Citra, and Ziske Maritska. "DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE." Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya 9, no. 1 (2022): 117–22. http://dx.doi.org/10.32539/jkk.v9i1.16554.

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Drug-resistant tuberculosis is a public health concern. TB that is drug-resistant to rifampin and isoniazid is known as MDR-TB, whereas XDR-TB is MDR-TB that is also resistant to second-line medicines, such as fluoroquinolones (levofloxacin, ofloxacin, and moxifloxacin). rifampin-resistant tuberculosis (RR-TB), of which 78 percent had multidrug-resistant tuberculosis (MDR-TB) (MDR-TB). Fluoroquinolones are a class of broad-spectrum antimicrobials that have become increasingly popular in recent years. Fluoroquinolones have activity against Mycobacterium tuberculosis both in vitro and in vivo. F

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Espinosa-Pereiro, Juan, Adrian Sánchez-Montalvá, Maria Luisa Aznar, and Maria Espiau. "MDR Tuberculosis Treatment." Medicina 58, no. 2 (2022): 188. http://dx.doi.org/10.3390/medicina58020188.

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Multidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues to be one of the most important threats to controlling the TB epidemic. Over the last few years, there have been promising pharmacological advances in the paradigm of MDR TB treatment: new and repurposed drugs have shown excellent bactericidal and sterilizing activity against Mycobacterium tuberculosis and several all-oral short regimens to treat MDR TB have shown promising results. The purpose of this comprehensive review is to summarize the most important drugs currently used to treat MDR TB, the re

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Hema, Malini, Huriani Emil, Putri Lenggogeni Devia, and Herlina Shinta. "Health education on multidrug-resistant tuberculosis prevention among tuberculosis patients." International Journal of Public Health Science (IJPHS) 10, no. 1 (2021): 27~32. https://doi.org/10.11591/ijphs.v10i1.20423.

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The high incidence of multidrug-resistant tuberculosis (MDR-TB) in the community due to the lack of socialization or the provision of health education about MDR-TB. During this time, health education is only focused on tuberculosis (TB) generally. The purpose of this study was to determine the effect of health education on the behavior of MDR-TB prevention in patients with pulmonary tuberculosis in two Community Health Centers in Padang. This study design is quasi-experimental with pre and post-test groups only. The program intervention of health education was conducted for a month with lectur

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Kobayashi, Kazuo, Manabu Ato, and Sohkichi Matsumoto. "Global Threats and the Control of Multidrug-Resistant Tuberculosis." Journal of Disaster Research 6, no. 4 (2011): 443–50. http://dx.doi.org/10.20965/jdr.2011.p0443.

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About one-third of the world’s population has been infected with Mycobacterium tuberculosis. Active disease develops in about 9 million people per year, and tuberculosis is responsible for 2 million deaths per year. The disease caused by this bacterium, tuberculosis (TB), remains one of the leading causes of mortality caused by infection worldwide and is a major threat to global health. The situation of TB is recently exacerbated by the emergence of highly drug-resistant forms of the disease-causing pathogen and synergy with human immunodeficiency virus/acquired immune deficiency syndrome, whi

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Ali, Monadil H., Alian A. Alrasheedy, Mohamed Azmi Hassali, Dan Kibuule, and Brian Godman. "Predictors of Multidrug-Resistant Tuberculosis (MDR-TB) in Sudan." Antibiotics 8, no. 3 (2019): 90. http://dx.doi.org/10.3390/antibiotics8030090.

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Multidrug-resistant tuberculosis (MDR-TB) is a global public health threat and burden on the health system. This is especially the case in high tuberculosis (TB) prevalence countries, such as Sudan. Consequently, this study aimed to ascertain the predictors of MDR-TB in Sudan to provide future guidance. An unmatched case-control study to assess the predictors of MDR-TB infections among the Sudanese population was conducted from August 2017 to January 2018 at Abu-Anga referral hospital. Patients’ data was gathered from patients’ cards and via interviews. A structured pre-validated questionnaire

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Malini, Hema, Emil Huriani, Devia Putri Lenggogeni, and Shinta Herlina. "Health education on multidrug-resistant tuberculosis prevention among tuberculosis patients." International Journal of Public Health Science (IJPHS) 10, no. 1 (2021): 27. http://dx.doi.org/10.11591/ijphs.v10i1.20423.

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The high incidence of multidrug-resistant tuberculosis (MDR-TB) in the community due to the lack of socialization or the provision of health education about MDR-TB. During this time, health education is only focused on tuberculosis (TB) generally. The purpose of this study was to determine the effect of health education on the behavior of MDR-TB prevention in patients with pulmonary tuberculosis in two Community Health Centers in Padang. This study design is quasi-experimental with pre and post-test groups only. The program intervention of health education was conducted for a month with lectur

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Aygün, Deniz, Tarık Yıldırım, Özlem Başoğlu Öner, et al. "Multidrug-Resistant Tuberculosis in Children: A Single-Center Experience." Journal of Pediatric Infection 54, no. 4 (2020): 208–14. http://dx.doi.org/10.5578/ced.69525.

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Objective: Resistance to at least isoniazid and rifampicin, which are the most important drugs in TB treatment, is called multidrug-resistant tuberculosis (MDR-TB). MDR-TB is a life-threatening condition that affects children as well as adults. Material and Methods: The medical records of children diagnosed with MDR-TB between June 2015 and October 2018 were analyzed retrospectively. Results: Seven female (77.8%) and two male (22.2%) patients were included into the study. Their mean age was 11.58 ± 4.23 years (3.75-15 years). Five patients (55.5%) had family members with MDR-TB. All of them ha

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Aygün, Deniz, Tarık Yıldırım, Özlem Başoğlu Öner, et al. "Multidrug-Resistant Tuberculosis in Children: A Single-Center Experience." Journal of Pediatric Infection 54, no. 4 (2020): 188–94. http://dx.doi.org/10.5578/ced.202063.

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Objective: Resistance to at least isoniazid and rifampicin, which are the most important drugs in TB treatment, is called multidrug-resistant tuberculosis (MDR-TB). MDR-TB is a life-threatening condition that affects children as well as adults. Material and Methods: The medical records of children diagnosed with MDR-TB between June 2015 and October 2018 were analyzed retrospectively. Results: Seven female (77.8%) and two male (22.2%) patients were included into the study. Their mean age was 11.58 ± 4.23 years (3.75-15 years). Five patients (55.5%) had family members with MDR-TB. All of them ha

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LIU, C. H., H. M. LI, L. LI, et al. "Anti-tuberculosis drug resistance patterns and trends in a tuberculosis referral hospital, 1997–2009." Epidemiology and Infection 139, no. 12 (2011): 1909–18. http://dx.doi.org/10.1017/s0950268810003158.

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SUMMARYInformation about the changing epidemiology of drug-resistant tuberculosis (TB) in hospitals in China over the past decade remains largely unknown. This study examined the susceptibility patterns and trends of drug-resistant TB cases in the 309 Hospital in Beijing, China. Mycobacterium tuberculosis isolates were retrospectively identified, drug susceptibility test (DST) results and clinical data were analysed for the period 1997–2009. Of the 5523 culture-positive TB patients, 47·1% had resistance to any anti-TB drug, 14·8% had mono-resistant TB, 19·8% had poly-resistant TB, 19·4% had mu

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Td, Neethu, and Mebin Alias. "CURRENT STRATEGIES IN THE TREATMENT OF MULTIDRUG-RESISTANT TUBERCULOSIS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 7 (2018): 70. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.25651.

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Objective: The objective of the study was to analyze and review the current knowledge about the principles of treatment of multidrug-resistant tuberculosis (MDR-TB), World Health Organization treatment regimen to treat MDR-TB, mechanism of resistance, and risk factors for emergence of resistance, and novel antitubercular drugs (ATDs) available and control measures to improve treatment outcomes of MDR-TB.Methods: Various articles were reviewed from PubMed and other databases and were analyzed to write the review.Results: Mycobacterium is a largely curable infectious disease if proper treatment

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Aisyah, Wa Ode Nur, Yusuf Sabilu, and La Ode Liaumin Azim. "Faktor risiko Multidrug Resistant Tuberculosis (MDR-TB) di Kota Kendari Tahun 2024." Indonesian Journal of Health Science 4, no. 6s (2024): 917–28. https://doi.org/10.54957/ijhs.v4i6s.1278.

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Introduction: The World Health Organization (WHO) estimates that 10 million people globally are affected by tuberculosis, underscoring the significant impact of this disease. The greatest challenge to global tuberculosis eradication efforts is multidrug-resistant tuberculosis (MDR-TB), a form of tuberculosis resistant to at least isoniazid and rifampicin, the two most effective and widely used tuberculosis drugs. In 2021, the global incidence of multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) was estimated to be around 450,000 cases, reflecting a 3.1% increase from the 43

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Rabab, Batool, Imran Muhammad, Hafeez Kandhro Abdul, Salahuddin Naseem, and K. H. Uddin Muhammad. "Resistance Patterns among Multidrug-Resistant Tuberculosis Patients: A Multi-Center Study from Pakistan." International Journal of Endorsing Health Science Research 5, no. 4 (2017): 07–11. https://doi.org/10.29052/IJEHSR.v5.i4.2017.07-11.

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Abstract <strong>Background:</strong> The high burden of multi-drug resistance tuberculosis (MDR TB) is a matter of great concern.  The increasing resistance to anti tuberculosis drugs has been the area of growing concern and are posing threats to TB control. The aim of this study was to evaluate the drug resistance patterns for the first line and second line anti-Tuberculosis drugs in multiple drug resistant tuberculosis (MDR-TB) patients. <strong>Method:</strong> The study was retrospective, observational, employing purposive, non-random sampling technique for data collection

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Nugraha, Rhea Veda, Vycke Yunivita, Prayudi Santoso, Rob E. Aarnoutse, and Rovina Ruslami. "Clofazimine as a Treatment for Multidrug-Resistant Tuberculosis: A Review." Scientia Pharmaceutica 89, no. 2 (2021): 19. http://dx.doi.org/10.3390/scipharm89020019.

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Multidrug-resistant tuberculosis (MDR-TB) is an infectious disease caused by Mycobacterium tuberculosis which is resistant to at least isoniazid and rifampicin. This disease is a worldwide threat and complicates the control of tuberculosis (TB). Long treatment duration, a combination of several drugs, and the adverse effects of these drugs are the factors that play a role in the poor outcomes of MDR-TB patients. There have been many studies with repurposed drugs to improve MDR-TB outcomes, including clofazimine. Clofazimine recently moved from group 5 to group B of drugs that are used to treat

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Nugrahaeni, Dyan Kunthi, and Salma Zaqiya. "The Relationship between Previous Tuberculosis Treatment and HIV Status with Multidrug-Resistant Tuberculosis." Jurnal Kesehatan Masyarakat 14, no. 3 (2019): 347–52. http://dx.doi.org/10.15294/kemas.v14i3.14087.

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Multidrug-resistant tuberculosis (MDR-TB) is becoming major public health issues in the world. Among the causes are history of previous TB treatment and increased co-infection of TB-HIV (Human Immunodeficiency Virus). This study aimed to identify the relationship between history of previous TB treatment and HIV status with MDR-TB. This is a case control study. The sample case was patients with MDR-TB, while sample control was patient who have drug-sensitive TB. Secondary data was obtained from patient medical records and laboratory results at Rotinsulu Pulmonary Hospital Bandung. Data were ana

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Yang, Yan, and Jianqing Wu. "Significance of the Differential Peptidome in Multidrug-Resistant Tuberculosis." BioMed Research International 2019 (January 17, 2019): 1–12. http://dx.doi.org/10.1155/2019/5653424.

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Most multidrug-resistant tuberculosis (MDR-TB) patients fail to receive a timely diagnosis and treatment. Therefore, we explored the differentially expressed peptides in MDR-TB compared with drug-susceptible tuberculosis (DS-TB) patients using LC-MS/MS and Ingenuity Pathway Analysis (IPA) to analyse the potential significance of these differentially expressed peptides. A total of 301 peptides were differentially expressed between MDR-TB and DS-TB groups. Of these, 24 and 16 peptides exhibited presented high (fold change ≥ 2.0, P < 0.05) and low (fold change ≤ −2.0, P < 0.05) levels in MD

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Cula, Eugenia. "Recent advances in the treatment of drug resistant tuberculosis." Bulletin of the Academy of Sciences of Moldova. Medical Sciences 79, no. 2 (2024): 203–5. https://doi.org/10.52692/1857-0011.2024.2-79.38.

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Multidrug-resistant (MDR TB) tuberculosis (TB), resistant to isoniazid and rifampicin, continues to be one of the most important threats to controlling the TB epidemic. Over the last few years, there have been promising advances in the paradigm of MDR TB treatment: new drugs have shown activity against Mycobacterium tuberculosis (MBT) and several all-oral short regimens to treat MDR TB have shown promising results. The purpose of this comprehensive review is to summarize the recommended regimens to treat MDR TB, and we also summarize new insights into the treatment of patients with MDR TB.

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Kajla, Deepak, Veerta Sharma, Ashi Mannan, Tanveer singh, and Pankaj Kumar Singh. "Current Status of Multi Drug Resistance- Tuberculosis: A Major Public-Health Threat." Journal of Pharmaceutical Technology, Research and Management 12, no. 2 (2024): 83–97. https://doi.org/10.15415/jptrm.2024.122007.

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Background: Rifampicin is the most effective first-line antibiotic for tuberculosis (TB). However, drug resistance, particularly multidrug-resistant TB (MDR-TB), poses a significant global health challenge. According to the World Health Organization (WHO), approximately 500,000 new TB cases in 2019 were resistant to treatment, with 78% showing multidrug resistance. India alone accounted for 27% of all MDR or rifampicin-resistant (RR) TB cases reported in 2020. MDR-TB, defined by resistance to at least isoniazid and rifampicin, is primarily driven by poor adherence to treatment, inappropriate a

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Damayanti, Aswita, and Alfi Raudatil Jannah. "Case Report: Multidrug-resistant Tuberculosis (MDR TB)." Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) 1, no. 3 (2018): 147. http://dx.doi.org/10.22146/rpcpe.41700.

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...................... The patient lived with her husband, her three children, and a very old mother-in-law. The patient was the first child of 2 siblings with a history of spontaneous birth and was assisted by a birth attendant with cry spontaneously. Her mother-in-law had the same history of the disease, i.e., the first category of pulmonary TB. Her mother-in-law was treated at the primary health care facility for six months and was declared cured by the primary health care facility ten years ago. Her sister-in-law also suffered from the third category of pulmonary TB and did not regularly t

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Chaudhari, Kavita S., Harun M. Patel, and Sanjay J. Surana. "Pyridines: Multidrug-resistant tuberculosis (MDR-TB) inhibitors." Indian Journal of Tuberculosis 64, no. 2 (2017): 119–28. http://dx.doi.org/10.1016/j.ijtb.2016.11.012.

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Arifah, Nur, Tintin Sukartini, and Harmayetty Harmayetty. "Karakteristik Pasien Multidrug Resistant Tuberculosis (MDR-TB) di RSUD Makassar." Jurnal Penelitian Kesehatan "SUARA FORIKES" (Journal of Health Research "Forikes Voice") 10, no. 4 (2019): 253. http://dx.doi.org/10.33846/sf10401.

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The case of multidrug resistant tuberculosis (MDR-TB) has become a threat to world health security. MDR / RR-TB causes 230,000 deaths in 2017 and most cases and deaths occur in Asia including Indonesia. MDR-TB cases that fail or are lost to treatment are one of the problems controlling MDR-TB because they can be a source of spread of treatment-resistant Mycobacterium Tuberculosis. This study aims to describe the characteristics of MDR-TB patients undergoing treatment at Makassar Hospital. This study uses qualitative studies with a phenomenological approach. The participants in this study were

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van Rijn, Sander P., Richard van Altena, Onno W. Akkerman, et al. "Pharmacokinetics of ertapenem in patients with multidrug-resistant tuberculosis." European Respiratory Journal 47, no. 4 (2016): 1229–34. http://dx.doi.org/10.1183/13993003.01654-2015.

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Treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is becoming more challenging because of increased levels of drug resistance against second-line TB drugs. One promising group of antimicrobial drugs is carbapenems. Ertapenem is an attractive carbapenem for the treatment of MDR- and XDR-TB because its relatively long half-life enables once-daily dosing.A retrospective study was performed for all patients with suspected MDR-TB at the Tuberculosis Center Beatrixoord of the University Medical Center Groningen (Haren, the Netherlands) who received ertapen

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Zhao, Li-li, Qing Sun, Hai-can Liu, et al. "Analysis ofembCABMutations Associated with Ethambutol Resistance in Multidrug-Resistant Mycobacterium tuberculosis Isolates from China." Antimicrobial Agents and Chemotherapy 59, no. 4 (2015): 2045–50. http://dx.doi.org/10.1128/aac.04933-14.

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ABSTRACTEthambutol (EMB) plays a pivotal role in the chemotherapy of drug-resistant tuberculosis (TB), including multidrug-resistant tuberculosis (MDR-TB). Resistance to EMB is considered to be caused by mutations in theembCABoperon (embC,embA, andembB). In this study, we analyzed theembCABmutations among 139 MDR-TB isolates from China and found a possible association betweenembCABoperon mutation and EMB resistance. Our data indicate that 56.8% of MDR-TB isolates are resistant to EMB, and 82.2% of EMB-resistant isolates belong to the Beijing family. Overall, 110 (79.1%) MDR-TB isolates had at

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Aswar, Sophian, and Febry Istyanto. "Analisis Faktor Risiko Multidrug Resistant Tuberculosis (MDR-TB) Pada Penderita Tuberkolusis Di Kabupaten Biak Numfor." JURNAL KESEHATAN TROPIS INDONESIA 1, no. 4 (2023): 1–8. https://doi.org/10.63265/jkti.v1i4.32.

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Tuberkulosis resisten obat adalah keadaan dimana kuman TB (Mycobacterium tubeculosis) telah kebal terhadap OAT (Obat Anti Tuberkulosis) yaitu Rifampicin-Resistant Tuberculosis (RR-TB: resisten terhadap RIF), Multidrug-resistant Tuberculosis (MDR-TB: resisten terhadap INH dan RIF) serta Extensively-resistant Tuberculosis (XDR) strain MDR yang resisten terhadap Quinolone dan salah satu obat grup A (Levofloksasin/ Moxifloksasin, Bedaquiline, Linezolid). Faktor risiko apakah yang mempengaruhi kejadian Multi Drug Resistance Tubercolusi (MDR-TB) pada penderita tubercolusis dikabupaten Biak Numfor. P

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Yang, Chongguang, Benjamin Sobkowiak, Vijay Naidu, et al. "Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis." PLOS Medicine 19, no. 2 (2022): e1003933. http://dx.doi.org/10.1371/journal.pmed.1003933.

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Background The incidence of multidrug-resistant tuberculosis (MDR-TB) remains critically high in countries of the former Soviet Union, where >20% of new cases and >50% of previously treated cases have resistance to rifampin and isoniazid. Transmission of resistant strains, as opposed to resistance selected through inadequate treatment of drug-susceptible tuberculosis (TB), is the main driver of incident MDR-TB in these countries. Methods and findings We conducted a prospective, genomic analysis of all culture-positive TB cases diagnosed in 2018 and 2019 in the Republic of Moldova. We use

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Barroso, Elizabeth Clara, Rosa Maria Salani Mota, Raimunda Oliveira Santos, Ana Lúcia Oliveira Sousa, Joana Brasileiro Barroso, and Jorge Luís Nobre Rodrigues. "Risk factors for acquired multidrug-resistant tuberculosis." Jornal de Pneumologia 29, no. 2 (2003): 89–97. http://dx.doi.org/10.1590/s0102-35862003000200008.

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Multidrug-resistant tuberculosis (MDR-TB) is a severe and feared problem, that is difficult to control and has shown a tendency to increase worldwide. OBJECTIVE: To analyze the risk factors for acquired MDR-TB. CASUISTIC AND METHODS: A retrospective population-based case-control study was conducted. A bacillus was considered multidrug-resistant whenever it was resistant at least to rifampin (RFP) + isoniazid (INH), and a case was considered as sensitive tuberculosis (TB) if it had undergone the first treatment during a similar period as the first treatment of an MDR-TB case, but was cured at t

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Abdulmughni, Jihan, Esam Mohammed Mahyoub, Abdulaziz Thabit Alaghbari, Abdulwahed Abdelgabar Al Serouri, and Yousef Khader. "Performance of Multidrug-Resistant Tuberculosis Surveillance in Yemen: Interview Study." JMIR Public Health and Surveillance 5, no. 4 (2019): e14294. http://dx.doi.org/10.2196/14294.

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Background Multidrug-resistant tuberculosis (MDR-TB) is a major challenge to ending TB occurrence by 2035. In Yemen, the 2011 survey showed an MDR-TB prevalence of 1.4% among new cases and 14.4% among previously treated cases. The National Tuberculosis Control Program (NTCP) established four MDR-TB sentinel surveillance sites in 2013 to monitor the MDR-TB situation. In Yemen, the 2011 survey showed an MDR-TB prevalence of 1.4% among new cases and 14.4% among previously treated cases. The NTCP established four MDR-TB sentinel surveillance sites in 2013 to monitor the MDR-TB situation. Objective

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Francisco, Christian, Mary Ann Lansang, Edsel Maurice Salvana, and Katerina Leyritana. "Multidrug-resistant tuberculosis (MDR-TB) and multidrug-resistant HIV (MDR-HIV) syndemic: challenges in resource limited setting." BMJ Case Reports 12, no. 8 (2019): e230628. http://dx.doi.org/10.1136/bcr-2019-230628.

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Tuberculosis (TB) is common among persons living with HIV. This public health concern is aggravated by infection with multidrug-resistant organisms and adverse effects of polypharmacy. There are few published cases of multidrug-resistant tuberculosis (MDR-TB) in multidrug-resistant HIV (MDR-HIV) infected patients. We report a case of a 29-year-old Filipino man with HIV on zidovudine (AZT)-containing antiretroviral therapy (ART) but was eventually shifted to tenofovir due to anaemia. He presented with left flank tenderness, which was found to be due to an MDR-TB psoas abscess, and for which sec

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