Relevant bibliographies by topics / Multifunctional agent

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Multifunctional agent'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Multifunctional agent"

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Na, Jung-Im, Jung-Won Shin, Hye-Ryung Choi, Soon-Hyo Kwon, and Kyung-Chan Park. "Resveratrol as a Multifunctional Topical Hypopigmenting Agent." International Journal of Molecular Sciences 20, no. 4 (2019): 956. http://dx.doi.org/10.3390/ijms20040956.

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Melanin is produced in melanocytes and stored in melanosomes, after which it is transferred to keratinocytes and, thus, determines skin color. Despite its beneficial sun-protective effects, abnormal accumulation of melanin results in esthetic problems. A range of topical hypopigmenting agents have been evaluated for their use in the treatment of pigmentary disorders with varying degrees of success. Hydroquinone (HQ), which competes with tyrosine, is the main ingredient in topical pharmacological agents. However, frequent occurrence of adverse reactions is an important factor that limits its use. Thus, efforts to discover effective topical hypopigmenting agents with less adverse effects continue. Here, we describe the potential of resveratrol to function as an effective hypopigmenting agent based on its mechanism of action. Resveratrol is not only a direct tyrosinase inhibitor but an indirect inhibitor as well. Additionally, it can affect keratinocytes, which regulate the function of melanocytes. Resveratrol regulates the inflammatory process of keratinocytes and protects them from oxidative damage. In this way, it prevents keratinocyte-induced melanocyte stimulation. Furthermore, it has a rescuing effect on the stemness of interfollicular epidermal cells that can repair signs of photoaging in the melasma, a typical pigmentary skin disorder. Overall, resveratrol is a promising potent hypopigmenting agent.
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Shakya, Anshul, Hans Raj Bhat, and Surajit Kumar Ghosh. "Update on Nitazoxanide: A Multifunctional Chemotherapeutic Agent." Current Drug Discovery Technologies 15, no. 3 (2018): 201–13. http://dx.doi.org/10.2174/1570163814666170727130003.

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Fried, Levi E., and Jack L. Arbiser. "Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent." Antioxidants & Redox Signaling 11, no. 5 (2009): 1139–48. http://dx.doi.org/10.1089/ars.2009.2440.

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Chen, Zhi-Yi, Yi-Xiang Wang, Yan Lin, et al. "Advance of Molecular Imaging Technology and Targeted Imaging Agent in Imaging and Therapy." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/819324.

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Molecular imaging is an emerging field that integrates advanced imaging technology with cellular and molecular biology. It can realize noninvasive and real time visualization, measurement of physiological or pathological process in the living organism at the cellular and molecular level, providing an effective method of information acquiring for diagnosis, therapy, and drug development and evaluating treatment of efficacy. Molecular imaging requires high resolution and high sensitive instruments and specific imaging agents that link the imaging signal with molecular event. Recently, the application of new emerging chemical technology and nanotechnology has stimulated the development of imaging agents. Nanoparticles modified with small molecule, peptide, antibody, and aptamer have been extensively applied for preclinical studies. Therapeutic drug or gene is incorporated into nanoparticles to construct multifunctional imaging agents which allow for theranostic applications. In this review, we will discuss the characteristics of molecular imaging, the novel imaging agent including targeted imaging agent and multifunctional imaging agent, as well as cite some examples of their application in molecular imaging and therapy.
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Aguilera, J. R., V. Venegas, J. M. Oliva, et al. "Targeted multifunctional tannic acid nanoparticles." RSC Advances 6, no. 9 (2016): 7279–87. http://dx.doi.org/10.1039/c5ra19405a.

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Akbari, Sweeta, Abdurahman Hamid Nour, Rosli Mohd Yunus, and Abdulrahman Hasan Farhan. "Biosurfactants as promising multifunctional agent: A mini review." International Journal of Innovative Research and Scientific Studies 1, no. 1 (2018): 1–5. http://dx.doi.org/10.53894/ijirss.v1i1.2.

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Biosurfactants are derived from plants and microorganisms such as fungi, yeast, and bacteria. Biosurfactants are also called natural surfactants which are amphiphilic biological compounds comprised of both hydrophilic and hydrophobic moieties. The environmental concerns about the effect of toxic and conventional surfactants have increased the demand for renewable and biodegradable surfactants with low toxicity and other useful effects. Therefore, the application of biosurfactants has gained much attention in different industries mainly in petroleum, food, cosmetic and pharmaceutical products. This review summarizes the utilization of biosurfactants as emulsifying, wetting, foaming and antimicrobial agents in various industrial processes along with their promising availability and ensuring environmental quality.
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Li, Jiaying, Huan Wang, Qianping Guo, et al. "Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent." International Journal of Molecular Sciences 20, no. 9 (2019): 2055. http://dx.doi.org/10.3390/ijms20092055.

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Poly(methyl methacrylate) (PMMA) bone cements have been widely used in clinical practices. In order to enhance PMMA’s imaging performance to facilitate surgical procedures, a supplementation of radiopaque agent is needed. However, PMMA bone cements are still facing problems of loosening and bacterial infection. In this study, a multifunctional coating to simultaneously encapsulate drug and prevent the infection of radiopaque agent has been developed. Barium sulfate (BaSO4), a common radiopaque agent, is used as a substrate material. We successfully fabricated porous BaSO4 microparticles, then modified with hexakis-(6-iodo-6-deoxy)-alpha-cyclodextrin (I-CD) and silver (Ag) to obtain porous BaSO4@PDA/I-CD/Ag microparticles. The porous nature and presence of PDA coating and I-CD on the surface of microparticles result in efficient loading and release of drugs such as protein. Meanwhile, the radiopacity of BaSO4@PDA/I-CD/Ag microparticles is enhanced by this multifunctional coating containing Ba, I and Ag. PMMA bone cements containing BaSO4@PDA/I-CD/Ag microparticles show 99% antibacterial rate against both Staphylococcus aureus (S. aureus) and Escherichia Coli (E. coli), yet without apparently affecting its biocompatibility. Together, this multifunctional coating possessing enhanced radiopacity, controlled drug delivery capability and exceptional antibacterial performance, may be a new way to modify radiopaque agents for bone cements.
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Naskar, Kinsuk, and Jacques W. M. Noordermeer. "Dynamically Vulcanized PP/EPDM Blends: Multifunctional Peroxides as Crosslinking Agents — Part I." Rubber Chemistry and Technology 77, no. 5 (2004): 955–71. http://dx.doi.org/10.5254/1.3547862.

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Abstract Thermoplastic vulcanizates (TPVs) or dynamic vulcanizates are a special class of thermoplastic elastomers, produced by mixing and crosslinking of a rubber and a thermoplastic polymer simultaneously. In a previous study, it was demonstrated that the use of dicumyl peroxide in combination with triallyl cyanurate as crosslinking agents provides a good overall balance of physical properties of PP/EPDM TPVs. Commonly used peroxides like dicumyl peroxide generally produce volatile decomposition products, which sometimes provide a typical smell or show a blooming effect. In this paper multifunctional peroxides are described, which reduce the above-mentioned problems. They consist of a peroxide and co-agent-functionality combined in a single molecule. The multifunctional peroxides provide properties of TPVs, which are comparable with commonly employed co-agent assisted peroxides. The solubility and kinetic aspects of the various peroxides are highlighted, as well as the decomposition products of the multifunctional peroxides with respect to the avoidance of smelly by-products. Particularly, 2,4-diallyoxy-6-tert-butylperoxy-1,3,5-triazine turns out to be a very good alternative to the dicumyl peroxide/triallyl cyanurate combination.
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Wei, Ruoyan, Wensong Xi, Haifang Wang, et al. "In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy." Nanoscale 9, no. 35 (2017): 12885–96. http://dx.doi.org/10.1039/c7nr02280h.

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A multifunctional nanocomposite was synthesized by linking pH-responsive prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles, which is bioimaging-guided multifunctional synergistic therapy agent.
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Hamzah, Mohammad Amir, Fan Liu, Lin Wei He, Ying Jie Cai, and Ping Zhang. "Application of Multifunctional Scouring Agent for Cotton Fabric Bleaching." Advanced Materials Research 1120-1121 (July 2015): 193–97. http://dx.doi.org/10.4028/www.scientific.net/amr.1120-1121.193.

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Multi-functional scouring agent (M.F.S.A.) successfully can replace caustic soda, soda ash, scouring agent and H2O2 –bleach stabilizer. It has strong properties of washing, dispersing, emulsifying and chelating, particularly applicable to bleach bath. In this experiment three processes like desizing, scouring and bleaching were done by single stage. Grey fabrics (woven) were treated by using various concentrations of M.F.S.A. and H2O2 at different temperature variation. The maximum value of whiteness of treated fabric were found at 80°C by using the concentration of M.F.S.A. and H2O2 (3.0 g/L and 3.0 g/L respectively). Also minimize required number of chemical used for bleaching process; here only two chemicals used for whole process. No additional chemicals used for water treatment and washing of treated fabric. After process only cold wash were done. Finally by using less concentration of both M.F.S.A. and H2O2 have got comparatively better result for whiteness and tensile strength.
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Dissertations / Theses on the topic "Multifunctional agent"

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Imperiale, Vita. "Design and formulation of a bespoke self-healing agent for repair of multifunctional fibre reinforced polymers." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582821.

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The aim of this investigation was to design a bespoke self-healing agent (SHA) formulation in order to achieve a fully autonomous healing functionality, which provides effective and timely in-situ repair of FRP composite laminates. The preliminary phase of the design process consisted of the identification of the SHA requirements, the choice of epoxy resins as the most suitable chemistry and, finally, the selection of the best candidate species, amongst the many commercially available. Numerous formulations were then generated by the combination of the above components. Therefore, an initial downselection process, with chemical and physical properties characterisation was necessary to consider only a limited number of formulations for mechanical properties characterization. A Mode I fracture toughness test was considered as a means of final selection, the adhesive function being one of the most important functional requirements. Finally, the recovery of residual compressive strength after impact (CAI) was used as a validation method, which was able to demonstrate and quantify the self-healing recovery within a FRP laminate. A very low viscosity epoxy based formulation with a slightly higher fracture toughness than the host composite matrix and good degree of reactivity was selected as having the best overall performance. Adhesion, as a function of time and temperature, was further assessed in this formulation. It was demonstrated that a certain degree of load bearing ability can be achieved after limited reaction extent with full recovery of load bearing ability after 6 hours at 25°C. An ageing assessment of SHA demonstrated that after seven days exposure to 60°C the formulation possessed excellent adhesive properties. The novel integration of a two-part SHA, with the components segregated within different hollow glass fibres for a fully autonomous process, required the development of a suitable manufacturing and design of the FRP laminate. The damaged and self-healed samples achieved 93% of the strength relative to the initial pristine configuration. Besides an increase in the failure load, self-healing generated a significant change in the stress-strain characteristics, which restored a degree of linearity up to failure, and a reduction in the differential strains (and hence increased buckling resistance). The bleeding of the SHA from storage in the HGF to effect healing can be implied from ultrasonic C-scan analysis, where images of self- healing samples possessed fragmented and less defined delamination contours compared to the image of damaged samples without SHA within hollow glass fibres. This investigation has demonstrated that a fully autonomous recovery of a significant proportion of compressive strength in a CFRP is possible via self-healing. For the first time it has been demonstrated that a bespoke multi-component SHA is able to bleed from embedded HGF, self-mix and react to allow recovery of up to 93% of compressive strength, notwithstanding the presence of remaining damage within the CFRP laminate
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Vashchuk, Alina. "Synthèse, structure et propriétés de polycyanurates réticulés et de matériaux nanoporeux générés en utilisant des liquides ioniques." Thesis, Paris Est, 2019. http://www.theses.fr/2019PESC0046/document.

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Cette thèse de doctorat aborde de nouvelles conceptions de films à base de résines d’ester de cyanate (CER) en présence de liquides ioniques (LIs) en tant qu'agents multifonctionnels : catalyseurs, agents de modification réactifs, renforts ou agents porogènes. Les liquides ioniques de structures et de concentrations variables accélèrent de manière significative la polycyclotrimérisation du dicyanate d’ester de bisphenol E, en l'absence de tout solvant organique supplémentaire ou additif. Les réseaux de polycyanurates resultants dopés avec des liquides ioniques aprotiques peuvent constituer des matériaux prometteurs pour la production de structures photosensibles. De tels systèmes nanocomposites permettent la séparation, larécupération et le recyclage aisés des LIs par simple extraction, ce qui permet finalement l'obtention de films nanoporeux thermostables. Les caractéristiques de la porosité de ces matériaux dépendent de la concentration des LIs dans les précurseurs CERs. Les LIs protoniques contenant des groupements fonctionnels &gt;NH et -OH, indépendamment de leurmasse molaire, de la structure chimique du cation et de l'anion, sont incorporés chimiquement dans le réseau polycyanurate. Ainsi, les matériaux hybrides obtenus avec des fragments de liquides ioniques pourraient fournir d’excellents candidats pour des recherches futures sur les ionomères et les nanocomposites<br>This PhD thesis addresses new designs of cyanate ester resin (CER) films in the presence of ionic liquids as multifunctional agents: catalysts, reactive modifiers, fillers or porogens. It should be emphasized that ionic liquids (ILs) of varying structures and concentrations significantly accelerate the polycyclotrimerization of dicyanate ester of bisphenol E, in the absence of any additional organic solvent or additive. The resulting polycyanurate networks doped with aprotic ionic liquids can be promising materials for producing photosensitive structures. Such nanocomposite systems allow for easier separation, recovery, and recycling of ILs by mere extraction, which eventually affords thermally stable nanoporous films. The porosity features of these materials depend on the concentration of ILs in the CER precursors.Protic ILs containing functional &gt;NH and -OH groups, regardless of molar mass, chemical structure of cation and anion, chemically incorporate into the polycyanurate network, thus the resulting hybrid materials with fragments of ionic liquids could provide excellent candidates for future research in ionomers and nanocomposites
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Diop, Bocar Noël. "Élaboration de nanoparticules hybrides multifonctionnelles à base de silice par microémulsion inverse : application à la conception d’un agent antibactérien." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10281/document.

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Cette thèse a pour objectif l’élaboration de nanoparticules hybrides à base de silice par microémulsion inverse. Les nanoparticules de silice constituent une matrice de base permettant de confiner et de protéger des molécules organiques et/ou des nanoparticules métalliques. L’incorporation combinée de différentes entités dans la silice ouvre ainsi de larges perspectives de par l'introduction de nouvelles propriétés liées à la structure hybride. Afin d’élaborer de tels objets, nous avons utilisé des micelles inverses à base d'eau, de Triton X-100, d'hexanol et de cyclohexane comme milieu réactionnel. L’influence des conditions opératoires sur le contrôle de la taille des micelles inverses a d'abord été étudiée. Ces micelles inverses ont ensuite été mises à profit comme nanoréacteurs pour la synthèse de nanoparticules de silice par procédé sol-gel en utilisant les précurseurs alkoxysilanes adéquats. Nous avons regardé dans quelle mesure il était possible de contrôler la taille des nanoparticules de silice en fonction du pourcentage d’eau par rapport au tensioactif. Il a ainsi été possible d’accéder de façon reproductible à des nanoparticules avec de tailles variables, de 30 nm à 200 nm. Nous avons ensuite regardé qu'il était possible d'encapsuler au sein de cette matrice nanométrique des fluorophores et des nanoparticules d’or et d’argent de façon contrôlée. En vue d’assurer une bonne stabilisation colloïdale en solution, ces nanoparticules hybrides ont été fonctionnalisées d'une part par ajout d'un silane fonctionnel et d'autre part par click chemistry. Nous avons ainsi pu montrer qu’il est possible d’effectuer dans un même milieu micellaire l’ensemble des processus de fabrication de la nanoparticule hybride, de la matrice de silice à sa fonctionnalisation en passant par l’incorporation d’entités fonctionnelles. Cette méthode de synthèse séquentielle nous a ainsi permis de supprimer les étapes de purification et de redispersion qui peuvent s’avérer problématiques dans les procédés classiques. L’ensemble de ce travail a été mis à profit pour la conception d’un agent antibactérien à base de nanoparticules argent/silice capables d’empêcher la prolifération bactérienne grâce au relargage progressif des ions argent. Les tests effectués en solution comme sur le coton et le polyéthylène téréphtalate imprégnés montrent effectivement un caractère antibactérien certain de ces systèmes<br>This thesis aims at developing hybrid nanoparticles based on silica by reverse microemulsion. The silica nanoparticles are the basic matrix containing and protecting organic molecules and/or metallic nanoparticles. The combined incorporation of different entities within the silica opens wide prospects for the introduction of new properties related to the hybrid structure. To develop such objects, we used reverse micelles based on water, Triton X-100, hexanol and cyclohexan as reaction medium. The influence of operating conditions on the control of the size of reverse micelles was first studied. These micelles were then set to be used as nanoreactors for the synthesis of silica nanoparticles by sol-gel using suitable alkoxysilanes precursors. We monitored how it was possible to control the size of silica nanoparticles based on the water to surfactant ratio. It was thus possible to prepare in a reproducible way nanoparticles with sizes varying from 30 nm to 200 nm. We then investigated the possibility to encapsulate, in this nanoscaled matrix, fluorophores and nanoparticles of gold and silver in a controlled manner. To ensure a good colloidal stability in solution, these hybrid nanoparticles were, on the one hand, modified by adding a functional silane and, on the other hand, by click chemistry. We have thus shown that it is possible to perform, in a same micellar media, all of manufacturing process of the hybrid nanoparticle, from the silica matrix to its functionalization passing by the incorporation of functional entities. This method of sequential synthesis allowed us to bypass the purification and redispersion steps that can be problematic in the conventional methods. All this work has been extended to the design of an antibacterial agent based of silver/silica nanoparticles, capable of preventing bacterial growth through the gradual release of silver ions. Tests conducted in solution on the impregnated cotton and polyethylene terephtalate indeed show an interesting antibacterial character of these systems
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Zindo, Frank T. "Polycyclic propargylamine derivatives as multifunctional neuroprotective agents." University of the Western Cape, 2018. http://hdl.handle.net/11394/6748.

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Philosophiae Doctor - PhD<br>The abnormal death of neurons in the central nervous system of individuals suffering from neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, takes place by an intrinsic cell suicide programme known as apoptosis. This process is triggered by several stimuli, and consists of numerous pathways and cascades which lead to the death of neuronal cells. It is this multifactorial nature of neurodegenerative diseases that has over the years seen many researchers develop compounds that may serve as multi-target directed ligands (MTDLs) which could potentially confer neuroprotection by acting simultaneously on different receptors and target sites implicated in neurodegeneration. This study was aimed at developing MTDLs that may serve as neuroprotective agents by simultaneously (a) inhibiting N-methyl D-aspartate receptors (NMDAR) and blocking L-type voltage gated calcium channels (VGCC) thus regulating the Ca2+ influx mediated excitotoxic process; (b) inhibiting the monoamine oxidase enzymes A and -B (MAO-A/B) thus allowing increase in dopamine levels in the central nervous system and reducing the levels of the highly oxidative products produced by the activity of these enzymes; (c) possessing anti-apoptotic activity to halt the neuronal cell death process. In designing the compounds we focused on the structures of rasagiline and selegiline, two well-known MAO-B inhibitors and proposed neuroprotective agents, and of NGP1-01, a known VGCC blocker and NMDAR antagonist. The first series of compounds (reported in research article 1, Chapter 3), comprised polycyclic propargylamine and acetylene derivatives. Compounds 12, 15 and 16 from this series showed promising VGCC and NMDA receptor channel inhibitory activity ranging from 18 % to 59 % in micromolar concentrations, and compared favourably to the reference compounds. In the MAO-B assay, compound 10 exhibited weak MAO-B inhibition of 73.32 % at 300 μM. The rest of the series showed little to no activity on these target sites, despite showing significant anti-apoptotic activity. This suggested the compounds in this series to be exhibiting their neuroprotective action through some other mechanism(s) unexplored in this study.
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Kadernani, Yakub Esmail Y. E. "Novel adamantane derivatives as multifunctional neuroprotective agents." University of the Western Cape, 2013. http://hdl.handle.net/11394/4256.

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>Magister Scientiae - MSc<br>The pathology of neurodegenerative disorders involves multiple steps, and it is probably for this reason that targeting one particular step in a multi-step process has only yielded limited results. Nitric oxide (NO) is synthesised from L-Arginine by an enzyme known as nitric oxide synthase (NOS). Three isoforms of NOS exist, including endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). In the central nervous system (CNS), nNOS is involved in the synthesis of NO, which is involved in various neurological functions. NO is a free radical and this probably explains why an excess amount of it has been implicated in the development of neurodegenerative disorders. In the CNS, the Nmethyl- D-aspartate (NMDA) receptor in its active state allows the influx of calcium ions which activate nNOS thus increasing the amount of NO and other detrimental reactive nitrogen species within neuronal cells. Calcium entry through voltage-gated calcium channels (VGCC) may also contribute to this. Although calcium ions are important for physiological functioning, an excess is responsible for excitotoxicity, which can ultimately lead to neurodegeneration. Our aim was to synthesise a series of adamantane-derived compounds that act at multiple target sites in the neurodegenerative pathway. By conjugating benzyl and phenylethyl moieties with different functional groups (-H, -NO2, -NH2, -NHC(NH)NH2, -OCH3) to the amantadine structure, we aimed to synthesise compounds that display calcium channel and NMDA receptor (NMDAR) channel inhibition, as well as selective inhibition of nNOS. A series of compounds (-H, -NO2, -NH2, -OCH3) were obtained in yields that varied between 16.5 % and 90.25 %. These novel compounds were tested for calcium influx through VGCC and NMDAR inhibition using synaptoneurosomes isolated from rat brain homogenate against the reference compounds MK-801, NGP1-01, amantadine, memantine and nimodipine. A lack of success with the synthesis of the guanidine compounds prevented the use of the oxyhemoglobin capture assay for the determination of nNOS inhibitory activity of these compounds. The novel synthesised compounds display inhibitory activity towards VGCC and the NMDAR in the micromolar range. Further tests are recommended on compounds SE-1, SE-4, SE-11 and SE-12 as they displayed good inhibitory activity against both NMDAR- as well as ii KCl-mediated calcium influx. These novel compounds may be better therapeutic options than amantadine and memantine as they inhibit both NMDAR and VGCC-mediated calcium influx, whereas amantadine and memantine only inhibit NMDA-mediated calcium influx. These novel adamantane derived compounds may possibly serve as novel leads or potential therapeutic agents for the treatment of neurodegenerative disorders.
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Harper, Robert Anthony. "Phosphorylated nanoaggregates as multifunctional agents in oral health." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/phosphorylated-nanoaggregates-as-multifunctional-agents-in-oral-health(aa1c942c-9d5f-4f7a-9447-d068c177eef9).html.

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Oral microbial disease is highly prevalent globally and is being associated with a multitude of systemic illnesses. There is a vast range of oral health products containing tooth hardening and antimicrobial agents yet the problem persists. The aim of this thesis was to chemically modify the anti-inflammatory vitamin E in order to introduce novel substantive antimicrobial activity giving it multifunctional activity to combat oral disease. (+) Alpha tocopherol (α-T) was chemically modified by phosphorylation to generate (+) alpha tocopheryl phosphate (α-TP). (+) α-TP was observed to form nano sized aggregates with a μM critical aggregation constant when dispersed in Tris buffer. The addition of the phosphate group was found to introduce substantive antimicrobial activity as (+) α-TP retarded Streptococci biofilm growth, adhered to hydroxyapatite and inhibited salivary biofilm growth whilst (+) α-T did not. This activity was related to nanostructure architectures as (+) α-T formed spherical, non-surface adherent liposomes (563 ± 1 nm, -10.5 ± 0.2 mV) whilst (+) α-TP formed surface adherent, planar bilayer islands (175 ± 21 nm, -14.9 ± 3.5 mV). Tris facilitated (+) α-TP antimicrobial activity as when it was dispersed in phosphate buffer it did not penetrate, kill or retard biofilm bacterial growth. This was shown to be due to the presence of the ions affecting bacterial membrane packing, aggregate packing and aggregate charge. The small monolayer pressure increase of the (+) α-TP bilayer planar island interactions suggested the antibacterial mechanism was not likely to be simple lyses, but perhaps internalisation and enzymatic inhibition. The (+) α-TP bilayer planar islands swelled into micron sized aggregates when dispersed in cell culture media, selectivity killed macrophages and selectively inhibited monocyte chemoattractant 1 production from human gingival fibroblast cells. The strategy of utilising phosphorylated vitamin E nanoaggregates as multifunctional agents in oral health described herein represents a potential technology platform worthy of clinical evaluation.
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Livi, Sébastien. "Ionic liquids : multifunctional agents of the polymer matrices." Lyon, INSA, 2010. http://theses.insa-lyon.fr/publication/2010ISAL0101/these.pdf.

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An excellent thermal stability, a low saturated vapor pressure, a no flammability, a good ionic conductivity and the different cations / anions combinations possible of ionic liquids are currently the focus of the research. Because of its various benefits, they are as a new alternative in the polymer science, and particularly in the field of the nanocomposites where their use is currently limited to the function of surfactant for the layered silicates. However, before claiming the status of an alternative, it is necessary to highlight the benefits of their use on the final properties of polymer materials. Initially, the objective of this work was to synthesize different ionic liquids by the nature of cation and anion, but all bearing with long alkyl chains to allow greater compatibility with the matrix. Then, the excellent intrinsic properties of ionic liquids have motivated their use as structuring agents in a fluorinated aqueous dispersion. Thus, their role in ionic agents on the morphology, physical, thermal and mechanical properties was studied. In a second part, ionic liquids have been used as agents intercalating layered silicates and then confronted with conventional surfactants in order to prepare thermally stable clays for the preparation of nanocomposite thermoplastic / clay. In the last section, a small amount of organically modified clays were introduced by melt intercalation in two different matrices in order to highlight the effects of these new interfacial agents on the final properties of the material<br>Une excellente stabilité thermique, une faible pression de vapeur saturante, une ininflammabilité, une bonne conductivité ionique ainsi que les différentes combinaisons cations/anions possibles font des liquides ioniques l'objet d'un engouement grandissant de la Recherche. De part ces avantages, les LI se présentent comme une nouvelle voie dans le domaine des polymères, et en particulier dans le milieu des nanocomposites où leur utilisation est essentiellement limitée à la fonction de surfactant des silicates lamellaires. Néanmoins, avant de pouvoir prétendre à un statut d'alternative, il est nécessaire de mettre en évidence les effets bénéfiques de leur utilisation sur les propriétés finales des matériaux polymères. Dans un premier temps, l’objectif de ce travail a été de synthétiser des liquides ioniques différents par la nature de leur cation et anion mais tous porteurs de longues chaînes alkyles afin de permettre une meilleure compatibilité avec la matrice. Ensuite, les excellentes propriétés intrinsèques des liquides ioniques ont motivé leur utilisation comme agents structurants dans une dispersion aqueuse fluorée. Ainsi, leur rôle d’agents ioniques sur la morphologie, les propriétés physiques, thermiques et mécaniques a été étudié. Dans une seconde partie, les liquides ioniques ont été utilisés comme agents intercalants des silicates lamellaires puis confrontés aux surfactants conventionnels dans le but de préparer des argiles thermiquement stables pour la préparation de nanocomposites thermoplastiques/argiles. Dans une dernière partie, une faible quantité de ces argiles organiquement modifiées ont été introduites par intercalation à l'état fondu dans deux matrices différentes afin de mettre en évidence les effets de ces nouveaux agents interfaciaux sur les propriétés finales du matériau
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Contractor, Asfiya Q. "ANIONIC SYNTHESIS OF FUNCTIONAL POLYMERS USING MULTIFUNCTIONAL EPOXIDES AS LINKING AGENTS." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1134747109.

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Musakwa, Lovetone. "Chalcone and curcumin hybrids of indole propargylamines as multifunctional neuroprotective agents." University of the Western Cape, 2020. http://hdl.handle.net/11394/7959.

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Magister Pharmaceuticae - MPharm<br>Neurodegenerative disorders (NDs) are a range of chronic brain disorders that includes amongst others motor function loss. Parkinson’s disease (PD) is one of the common NDs that has an insidious onset and diagnosed when dopaminergic neurons in the substantia nigra are already lost. The loss creates a deficiency of the dopamine (neurotransmitter) thereby causing neurochemical imbalance resulting in the signs and symptoms of PD. NDs overlap at multiple levels so some of the symptoms overlap as well. NDs currently have no cure yet and current drug therapies only improve the quality of life of the patients by targeting the symptoms mainly. Treatment of PD currently involves different classes of drugs and depending on the stages of the disease, some drugs can be only used as an adjunct therapy. Anti-oxidants and monoamine oxidase inhibitors (MAO-I) are part of the treatment options.
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Denya, Ireen. "Design, Synthesis and Evaluation of Indole Derivatives as Multifunctional Agents against Alzheimer's disease." University of the Western Cape, 2017. http://hdl.handle.net/11394/5725.

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Magister Scientiae - MSc<br>Alzheimer's disease (AD) is an age related neurodegenerative disorder characterised by progressive memory loss and cognitive impairment. It is one of several neurodegenerative disorders occurring as a result of a process of programmed cell death known as apoptosis. The process is set off by various stimuli in numerous pathways that ultimately lead to apoptosis. AD stands out as one of the leading causes of death in the elderly in today's society. The cholinergic hypothesis of AD states that there is an extensive loss of cholinergic neurons in the central nervous system that contributes to cognitive impairment. Acetylcholinesterase inhibitors decrease the breakdown of the neurotransmitter acetylcholine to maintain its post synaptic levels and compensate for the loss of functional brain cells. Amyloid ? plaque formation has been shown to be extensively involved in the pathogenesis of AD. The abnormal regulation of the amyloid precursor protein gives rise to plaques that impair neuronal homeostasis and eventually lead to apoptosis. The monoamine oxidase enzymes catalyse the hydrolysis of amine neurotransmitters such as dopamine. The process produces peroxides that cause oxidative stress alongside the depletion of neurotransmitters. Inhibition of monoamine oxidase allows for accumulation of neurotransmitters and reduces the formation of oxidative free radicals to confer neuroprotection.
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Books on the topic "Multifunctional agent"

1

Hellmann, Kurt, and Walter Rhomberg, eds. Razoxane and Dexrazoxane - Two Multifunctional Agents. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-9168-0.

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Hellmann, K., and Walter Rhomberg. Razoxane and dexrazoxane: Two multifunctional agents : experimental and clinical results. Springer, 2010.

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Hellmann, Kurt, and Walter Rhomberg. Razoxane and Dexrazoxane - Two Multifunctional Agents: Experimental and Clinical Results. Springer, 2014.

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Bandosz, Teresa J., and Dimitrios A. Giannakoudakis. Detoxification of Chemical Warfare Agents: From WWI to Multifunctional Nanocomposite Approaches. Springer, 2018.

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Bandosz, Teresa J., and Dimitrios A. Giannakoudakis. Detoxification of Chemical Warfare Agents: From WWI to Multifunctional Nanocomposite Approaches. Springer, 2019.

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Burke, A., D. Carroll, Frank Torti, and S. V. Torti. Bifunctional nanomaterials for the imaging and treatment of cancer. Edited by A. V. Narlikar and Y. Y. Fu. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199533060.013.13.

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This article examines the potential of bifunctional nanomaterials for the imaging and treatment of cancer. Several nanomaterials possess properties desirable for a cancer therapy and have been the subject of research as anticancer agents. Those that have received the most attention include encapsulated iron oxides, single- and multiwalled carbon nanotubes, gold nanorods and gold nanoshells. This article first considers thermal ablative therapy incancer, focusing on the mechanisms of thermotoxicity and thermoresistance before discussing a number of nanomaterials with applications for cancer treatment. In particular, it evaluates the use of nanomaterials in thermal therapy. It also looks at gold nanoshells and nanorods, taking into account their physical properties, and concludes with an assessment of iron-oxide nanoparticles and future directions for nanomaterials as multifunctional agents for cancer therapy.
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Book chapters on the topic "Multifunctional agent"

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D’Haro, Luis Fernando, Seokhwan Kim, Kheng Hui Yeo, et al. "CLARA: A Multifunctional Virtual Agent for Conference Support and Touristic Information." In Natural Language Dialog Systems and Intelligent Assistants. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19291-8_22.

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Oltean, Virginia Ecaterina, Theodor Borangiu, and Silviu Răileanu. "On Capacity Measurement in Two Classes of Shop Floor Problems with Multifunctional Parallel Machines." In Service Orientation in Holonic and Multi-Agent Manufacturing. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-73751-5_36.

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Hellmann, Kurt. "Introduction." In Razoxane and Dexrazoxane - Two Multifunctional Agents. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9168-0_1.

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Hellmann, Kurt, and Walter Rhomberg. "Razoxane." In Razoxane and Dexrazoxane - Two Multifunctional Agents. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9168-0_2.

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Hellmann, Kurt, and Walter Rhomberg. "Dexrazoxane." In Razoxane and Dexrazoxane - Two Multifunctional Agents. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9168-0_3.

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Hellmann, Kurt, and Walter Rhomberg. "Summary and Outlook." In Razoxane and Dexrazoxane - Two Multifunctional Agents. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9168-0_4.

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Farrell, Nicholas, Yun Qu, and John D. Roberts. "Chemistry and Biology of Multifunctional DNA Binding Agents." In Metallopharmaceuticals I. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-662-03815-4_4.

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Gao, Chuang, and Zhifei Dai. "Multifunctional Ultrasound Contrast Agents Integrating Targeted Imaging and Therapy." In Advances in Nanotheranostics II. Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0063-8_4.

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Wei, Alexander, Alexei P. Leonov, and Qingshan Wei. "Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-609-2_8.

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Sami, Haider, J. Jaishree, Ashok Kumar, and Sri Sivakumar. "Multifunctional Nano/Micro Polymer Capsules as Potential Drug Delivery and Imaging Agents." In Nanomedicine for Drug Delivery and Therapeutics. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118636299.ch9.

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Conference papers on the topic "Multifunctional agent"

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Kosolapov, Andrey. "COMPARATIVE CHARACTERISTICS OF THE QUALITY INDICATORS OF SILAGE WHEN USING VARIOUS PRESERVING AGENT." In Multifunctional adaptive fodder production. Federal Williams Research Center of Forage Production and Agroecology, 2020. http://dx.doi.org/10.33814/mak-2020-24-72-145-150.

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A comparative assessment of the effectiveness of biological products of domestic production Biosib + Bioferm and a similar foreign Biotal Asidfast NS Gold for silage of perennial grasses of the first mowing is given. The advantage of the complex preparation Biosib + Bioferm has been established, the use of which leads to a higher content of crude and used protein, structural carbohydrates, metabolic and net lactation energy, and better digestibility of organic matter.
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Chen, Chenggang. "Factors Influencing the Morphology Development of Epoxy Nanocomposites." In ASME 2006 Multifunctional Nanocomposites International Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/mn2006-17083.

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Polymer nanocomposites draw great interest due to their unique nanostructures and improved properties [1–2]. Epoxy is a widely-used thermosetting material. The research on the epoxy layered-silicate epoxy nanocomposite has exploded in the last decade [3–9]. The morphology of nanocomposites is the key to making high-performance nanocomposites. In this presentation, the factors influencing the morphology development behavior of epoxy nanocomposites will be discussed. The factors to be investigated include organoclay, epoxide, and curing agent. In this study, the aliphatic diamine (Jeffamines) with different molecular weights and aromatic diamine were selected as the curing agents, S30B (quaternary onium-montmorillonite) and SC18 (primary oniummont-morillonite) as the organoclays, and Epon 862 and Epon 828 as epoxides. In situ small-angle x-ray scattering (SAXS) was utilized to study the morphology development of the epoxy nanocomposite.
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Wang, Xi. "Dynamic Mechanical Properties of Epoxy Resin with Multifunctional Polyamine Curing Agent." In 2015 International Conference on Advanced Material Engineering. WORLD SCIENTIFIC, 2015. http://dx.doi.org/10.1142/9789814696029_0027.

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Tai, Ming-Fong, Jong-Kai Hsiao, Hon-Man Liu, Shio-Chao Lee, and Shin-Tai Chen. "Synthesis Fe-Ni Alloy Magnetic Nanoparticles for Biomedical Applications." In ASME 2006 Multifunctional Nanocomposites International Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/mn2006-17041.

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In this investigation, we synthesize FeNi alloy magnetic nanoparticles (MNPs) by using both chemical precipitation and combustion methods. The FeNi MNPs prepared by combustion method have a rather high saturation magnetization Ms of ∼180 emu/g and a coercivity field Hc of near zero. The functionalized FeNi MNPs which were coated with biocompatible polyethyleneimine (PEI) polymer have also been synthesized. We demonstrated that the PEI coated FeNi MNPs can enter the mammalian cells in vitro and can be used as a magnetic resonance imagine (MRI) contrast agent. The results demonstrated that FeNi MNPs potentially could be applied in the biomedical field. To prepare a higher quality and well controlled Fe-Ni MNPs, we also developed a thermal reflux chemical precipitation method to synthesize FeNi3 alloy MNPs. The precursor chemicals of Fe(acac)3 and Ni(acac)2 in a molecular ratio of 1:3 reacted in octyl ether solvent at the boiling point of solvent (∼300°C) by the thermal reflux process. The 1,2-hexadecandiol and tri-n-octylphosphine oxide (TOPO) were used as reducer and surfactant, respectively. The chemically precipitated FeNi3 MNPs are well dispensed and have well-controlled particle sizes around 10–20 nm with a very narrow size distribution (± 1.2 nm). The highly monodispersive FeNi3 NPs present good uniformity in particle shape and crystallinity on particle surfaces. The MNPs exhibit well soft magnetism with saturation magnetization of ∼61 emu/g and Hc ∼ 0. The functionalized magnetic beads with biocompatible polymer coated on MNPs are also generated completed for biomedical applications.
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Rizvi, Hussain R., and Nandika D'Souza. "Design of a Multifunctional Porous Coaxial Electrospun Mesh Using Polycaprolactone (PCL) and Poly Butylene Adipate-CO-Terephthalate (PBAT)." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-67534.

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In this paper, we formulate a method to create a potential drug delivery vehicle and scaffold architecture of coaxial electrospun fibers. Having the capability to introduce porosity either in core or sheath of the fiber using supercritical CO2 as a foaming agent is utilized. Polycaprolactone (PCL) and Poly butylene adipate-co-terephthalate (PBAT) were used because of their biodegradable and biocompatible nature. Physical morphology of the porous coaxial fibers was studied using Scanning Electron Microscopy (SEM), Image J software was used to quantify the pore size and fiber diameter. Dynamic Mechanical Analysis (DMA) and Tensile Testing of the three-dimensional fibrous mesh was done to determine the mechanical properties of the porous structure. Differential Scanning Calorimeter (DSC) was used to study the thermal characteristics of the mesh.
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Anicescu, Maria-Cristina, Cristina-Elena Dinu-Pirvu, Mihaela Violeta Ghica, et al. "Preliminary analysis of emulsion-based formulations containing pumpkin seed oil and hemp seed oil for internal use." In The 8th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2020. http://dx.doi.org/10.24264/icams-2020.ii.1.

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With a long tradition in pharmaceutical design, emulsions are functional formulations that can maintain their adaptive power connected with the new formulation requirements. Hence, this study proposed preliminary assays concerning the obtaining of natural emulsions for oral administration, incorporating pumpkin seed oil and hemp seed oil as oil phases, with lecithin as emulsifying agent. Using emulsification method, O/W and W/O emulsions were prepared and characterized from a stability point of view considering organoleptic parameters, conductivity properties followed by an extensive superficial analysis by fitting two different goniometric approaches like contact angle and pendant drop models. The emulsions obtained were stable, homogeneous, their properties being reflected by composition. Conductivity values confirmed the type of emulsions, completing their profile. Superficial analysis revealed that lecithin can sustain a proper stability due to a variation of surface tension values around 25 mN/m. The mean contact angle values ranging between 31.87±0.51° and 44.01±5.48° defined an adequate wettability, being correlated with the internal structure. To conclude, this preliminary study offered important data concerning the stability of some emulsions for oral delivery, accessing natural biocompatible components. On this way, it can be created multifunctional systems with nutritional value, but also special vehicles designed for drug delivery.
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PIMOKHOVA, Lyudmila, Zhanna TSARAPNEVA, and Nina Kharaborkina. "EFFECTIVENESS OF DRESSER TANK MIXTURE FOR LUPIN CROPS PROTECTION AGAINST PATHOGEN COMPLEX." In Multifunctional adaptive fodder production. Federal Williams Research Center of Forage Production and Agroecology, 2020. http://dx.doi.org/10.33814/mak-2020-24-72-106-112.

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Annually lupin sowing material is infected by spores and mycelium of many economic important fungi which located both on the surface and inside of seeds. It’s necessary to use combined, complex or mixed dressers with wide spectrum of antifungal action to control it. Under field conditions it was revealed that the tank dresser’s mixture of Vitaros + Syncler (2.0 + 0.5 l/ha) is more effective against many diseases’ agents in white and narrow-leafed lupin crops compared to the single Vitaros (2.0 l/ha). Pre-sowing seed treatment of these lupin species with the above mentioned tank mixture decreased plant infection by anthracnose by 3.7 and 2.1%, by Fusarium — by 8.5 and 9.4% and by rizoctoniose — by 6.4 and 7.0% respectively. Its use for seeds disinfection improves phytosanitary situation in crops; the last one allows save the yield of narrow-leafed and white lupines in 0.10 and 0.14 t/ha respectively and increase net profit per a hectare.
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Sandri, Monica, Michele Iafisco, Silvia Panseri, Elisa Savini, and Anna Tampieri. "Fully Biodegradable Magnetic Micro-Nanoparticles: A New Platform for Tissue Regeneration and Theranostic." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93223.

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Nowadays, magnetic materials are receiving special attention due to their potential applications in different fields and in particular in medicine. Magnetic micro-nano-particles have been progressively employed as support materials for enzyme immobilization, and have been used as drug-delivery vehicles, contrast agents for magnetic resonance imaging as well as heat mediators for hyperthermia-based anti-cancer treatments and many other exciting biomedical applications. Magnetic materials have also attracted a big interest in the field of bone tissue regeneration because it has been demonstrated that magnetic nanoparticles have effect of osteoinduction even without external magnetic force. Therefore, one of the most big challenge in this field is the production of magnetic materials with good biocompatibility and biodegradability. In fact, the long-term effects in the human body of iron oxide (maghemite or magnetite), the most popular magnetic phase used in medicine and biotechnology, are not yet completely assessed. To this aim, in this work we developed an innovative biocompatible and bioresorbable superparamagnetic-like phase by doping nano-hydroxyapatite with Fe2+/Fe3+ ions (FeHA). Moreover the same magnetic nanoparticles were used as nano-particulate emulsifier for the preparation of hollow hybrid Fe-HA-poly(L-lactic) acid (PLLA) micro-nano-spheres. PLLA has been used because poly(α-hydroxy-esters) are the most frequently used synthetic polymers for biomedical applications owing to their biocompatibility, hydrolytic degradation process and proper mechanical properties. These micro-nanospheres could be used as new type of scaffold for hard tissue regeneration. In fact, spherical scaffold display several advantages respect to the monolithic counterpart e.g., (i) improving control over sustained delivery of therapeutic agents, signalling biomolecules and even pluripotent stem cells, (ii) serving as stimulus-sensitive delivery vehicles for triggered release, (iii) introducing porosity and/or improve the mechanical properties of bulk scaffolds by acting as porogen or reinforcement phase, (iv) supplying compartmentalized micro-reactors for dedicated biochemical processes, (v) functioning as cell delivery vehicle, and, finally, (vi) giving possibility of preparing injectable and/or mouldable formulations to be applied by using minimally invasive surgery. Moreover, the same magnetic materials could find applications in nanomedicine as a multifunctional carrier. Their magnetic functionality could be utilized to move them into the body towards target organs by an external magnetic field. Furthermore, the superparamagnetic feature of the nanoparticles could allow to tailor the release of the therapeutic agent by switching (on-off) the external magnetic field and/or to treat cancer cells by hyperthermia.
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Charlish, A., K. Woodbridge, and H. Griffiths. "Agent based multifunction radar surveillance control." In 2011 IEEE Radar Conference (RadarCon). IEEE, 2011. http://dx.doi.org/10.1109/radar.2011.5960652.

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Matsuura, Naomi. "Nanoengineering New Multifunctional Contrast Agents for Medical Imaging of Cancer." In International Conference of Theoretical and Applied Nanoscience and Nanotechnology. Avestia Publishing, 2017. http://dx.doi.org/10.11159/tann17.4.

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