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Journal articles on the topic 'Multifunctional agent'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Na, Jung-Im, Jung-Won Shin, Hye-Ryung Choi, Soon-Hyo Kwon, and Kyung-Chan Park. "Resveratrol as a Multifunctional Topical Hypopigmenting Agent." International Journal of Molecular Sciences 20, no. 4 (2019): 956. http://dx.doi.org/10.3390/ijms20040956.

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Melanin is produced in melanocytes and stored in melanosomes, after which it is transferred to keratinocytes and, thus, determines skin color. Despite its beneficial sun-protective effects, abnormal accumulation of melanin results in esthetic problems. A range of topical hypopigmenting agents have been evaluated for their use in the treatment of pigmentary disorders with varying degrees of success. Hydroquinone (HQ), which competes with tyrosine, is the main ingredient in topical pharmacological agents. However, frequent occurrence of adverse reactions is an important factor that limits its use. Thus, efforts to discover effective topical hypopigmenting agents with less adverse effects continue. Here, we describe the potential of resveratrol to function as an effective hypopigmenting agent based on its mechanism of action. Resveratrol is not only a direct tyrosinase inhibitor but an indirect inhibitor as well. Additionally, it can affect keratinocytes, which regulate the function of melanocytes. Resveratrol regulates the inflammatory process of keratinocytes and protects them from oxidative damage. In this way, it prevents keratinocyte-induced melanocyte stimulation. Furthermore, it has a rescuing effect on the stemness of interfollicular epidermal cells that can repair signs of photoaging in the melasma, a typical pigmentary skin disorder. Overall, resveratrol is a promising potent hypopigmenting agent.

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Shakya, Anshul, Hans Raj Bhat, and Surajit Kumar Ghosh. "Update on Nitazoxanide: A Multifunctional Chemotherapeutic Agent." Current Drug Discovery Technologies 15, no. 3 (2018): 201–13. http://dx.doi.org/10.2174/1570163814666170727130003.

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3

Fried, Levi E., and Jack L. Arbiser. "Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent." Antioxidants & Redox Signaling 11, no. 5 (2009): 1139–48. http://dx.doi.org/10.1089/ars.2009.2440.

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4

Chen, Zhi-Yi, Yi-Xiang Wang, Yan Lin, et al. "Advance of Molecular Imaging Technology and Targeted Imaging Agent in Imaging and Therapy." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/819324.

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Molecular imaging is an emerging field that integrates advanced imaging technology with cellular and molecular biology. It can realize noninvasive and real time visualization, measurement of physiological or pathological process in the living organism at the cellular and molecular level, providing an effective method of information acquiring for diagnosis, therapy, and drug development and evaluating treatment of efficacy. Molecular imaging requires high resolution and high sensitive instruments and specific imaging agents that link the imaging signal with molecular event. Recently, the application of new emerging chemical technology and nanotechnology has stimulated the development of imaging agents. Nanoparticles modified with small molecule, peptide, antibody, and aptamer have been extensively applied for preclinical studies. Therapeutic drug or gene is incorporated into nanoparticles to construct multifunctional imaging agents which allow for theranostic applications. In this review, we will discuss the characteristics of molecular imaging, the novel imaging agent including targeted imaging agent and multifunctional imaging agent, as well as cite some examples of their application in molecular imaging and therapy.

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Aguilera, J. R., V. Venegas, J. M. Oliva, et al. "Targeted multifunctional tannic acid nanoparticles." RSC Advances 6, no. 9 (2016): 7279–87. http://dx.doi.org/10.1039/c5ra19405a.

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Akbari, Sweeta, Abdurahman Hamid Nour, Rosli Mohd Yunus, and Abdulrahman Hasan Farhan. "Biosurfactants as promising multifunctional agent: A mini review." International Journal of Innovative Research and Scientific Studies 1, no. 1 (2018): 1–5. http://dx.doi.org/10.53894/ijirss.v1i1.2.

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Biosurfactants are derived from plants and microorganisms such as fungi, yeast, and bacteria. Biosurfactants are also called natural surfactants which are amphiphilic biological compounds comprised of both hydrophilic and hydrophobic moieties. The environmental concerns about the effect of toxic and conventional surfactants have increased the demand for renewable and biodegradable surfactants with low toxicity and other useful effects. Therefore, the application of biosurfactants has gained much attention in different industries mainly in petroleum, food, cosmetic and pharmaceutical products. This review summarizes the utilization of biosurfactants as emulsifying, wetting, foaming and antimicrobial agents in various industrial processes along with their promising availability and ensuring environmental quality.

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7

Li, Jiaying, Huan Wang, Qianping Guo, et al. "Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent." International Journal of Molecular Sciences 20, no. 9 (2019): 2055. http://dx.doi.org/10.3390/ijms20092055.

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Poly(methyl methacrylate) (PMMA) bone cements have been widely used in clinical practices. In order to enhance PMMA’s imaging performance to facilitate surgical procedures, a supplementation of radiopaque agent is needed. However, PMMA bone cements are still facing problems of loosening and bacterial infection. In this study, a multifunctional coating to simultaneously encapsulate drug and prevent the infection of radiopaque agent has been developed. Barium sulfate (BaSO4), a common radiopaque agent, is used as a substrate material. We successfully fabricated porous BaSO4 microparticles, then modified with hexakis-(6-iodo-6-deoxy)-alpha-cyclodextrin (I-CD) and silver (Ag) to obtain porous BaSO4@PDA/I-CD/Ag microparticles. The porous nature and presence of PDA coating and I-CD on the surface of microparticles result in efficient loading and release of drugs such as protein. Meanwhile, the radiopacity of BaSO4@PDA/I-CD/Ag microparticles is enhanced by this multifunctional coating containing Ba, I and Ag. PMMA bone cements containing BaSO4@PDA/I-CD/Ag microparticles show 99% antibacterial rate against both Staphylococcus aureus (S. aureus) and Escherichia Coli (E. coli), yet without apparently affecting its biocompatibility. Together, this multifunctional coating possessing enhanced radiopacity, controlled drug delivery capability and exceptional antibacterial performance, may be a new way to modify radiopaque agents for bone cements.

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8

Naskar, Kinsuk, and Jacques W. M. Noordermeer. "Dynamically Vulcanized PP/EPDM Blends: Multifunctional Peroxides as Crosslinking Agents — Part I." Rubber Chemistry and Technology 77, no. 5 (2004): 955–71. http://dx.doi.org/10.5254/1.3547862.

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Abstract Thermoplastic vulcanizates (TPVs) or dynamic vulcanizates are a special class of thermoplastic elastomers, produced by mixing and crosslinking of a rubber and a thermoplastic polymer simultaneously. In a previous study, it was demonstrated that the use of dicumyl peroxide in combination with triallyl cyanurate as crosslinking agents provides a good overall balance of physical properties of PP/EPDM TPVs. Commonly used peroxides like dicumyl peroxide generally produce volatile decomposition products, which sometimes provide a typical smell or show a blooming effect. In this paper multifunctional peroxides are described, which reduce the above-mentioned problems. They consist of a peroxide and co-agent-functionality combined in a single molecule. The multifunctional peroxides provide properties of TPVs, which are comparable with commonly employed co-agent assisted peroxides. The solubility and kinetic aspects of the various peroxides are highlighted, as well as the decomposition products of the multifunctional peroxides with respect to the avoidance of smelly by-products. Particularly, 2,4-diallyoxy-6-tert-butylperoxy-1,3,5-triazine turns out to be a very good alternative to the dicumyl peroxide/triallyl cyanurate combination.

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9

Wei, Ruoyan, Wensong Xi, Haifang Wang, et al. "In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy." Nanoscale 9, no. 35 (2017): 12885–96. http://dx.doi.org/10.1039/c7nr02280h.

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A multifunctional nanocomposite was synthesized by linking pH-responsive prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles, which is bioimaging-guided multifunctional synergistic therapy agent.

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10

Hamzah, Mohammad Amir, Fan Liu, Lin Wei He, Ying Jie Cai, and Ping Zhang. "Application of Multifunctional Scouring Agent for Cotton Fabric Bleaching." Advanced Materials Research 1120-1121 (July 2015): 193–97. http://dx.doi.org/10.4028/www.scientific.net/amr.1120-1121.193.

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Multi-functional scouring agent (M.F.S.A.) successfully can replace caustic soda, soda ash, scouring agent and H2O2 –bleach stabilizer. It has strong properties of washing, dispersing, emulsifying and chelating, particularly applicable to bleach bath. In this experiment three processes like desizing, scouring and bleaching were done by single stage. Grey fabrics (woven) were treated by using various concentrations of M.F.S.A. and H2O2 at different temperature variation. The maximum value of whiteness of treated fabric were found at 80°C by using the concentration of M.F.S.A. and H2O2 (3.0 g/L and 3.0 g/L respectively). Also minimize required number of chemical used for bleaching process; here only two chemicals used for whole process. No additional chemicals used for water treatment and washing of treated fabric. After process only cold wash were done. Finally by using less concentration of both M.F.S.A. and H2O2 have got comparatively better result for whiteness and tensile strength.

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Zhang, Ning, Bin Chen, Rong Li, Chen Li, An Fan, and Fei Huang. "A multifunctional chromatographic material modified with aminopolycarboxylic acid agent." Separation and Purification Technology 214 (May 2019): 181–86. http://dx.doi.org/10.1016/j.seppur.2018.03.061.

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12

Mustata, Fanica, and Ioan Bicu. "Multifunctional formaldehyde resins as curing agent for epoxy resins." Journal of Applied Polymer Science 115, no. 3 (2010): 1787–96. http://dx.doi.org/10.1002/app.31295.

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13

Yim, Hyeona, Seogjin Seo, and Kun Na. "MRI Contrast Agent-Based Multifunctional Materials: Diagnosis and Therapy." Journal of Nanomaterials 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/747196.

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Various imaging technologies have become increasingly important in developing a better understanding of information on the biological and clinical phenomena associated with diseases of interest. Of these technologies, magnetic resonance imaging (MRI) is one of the most powerful for clinical diagnosis and in vivo imaging without the exposure to ionising radiation or radiotracers. Despite its many advantages, there are intrinsic limitations caused by MRI contrast agents, such as short vascular half-life circulation, which lead to unwanted side effects. In this review, we will focus on the multifunctional modification of MRI contrast agents for diagnosis and therapy.

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14

Jiang, Z. G., X. C. M. Lu, V. Nelson, et al. "A multifunctional cytoprotective agent that reduces neurodegeneration after ischemia." Proceedings of the National Academy of Sciences 103, no. 5 (2006): 1581–86. http://dx.doi.org/10.1073/pnas.0510573103.

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15

Xie, Yun-Dong, Zi-Zhang Chen, Na Li, et al. "Hydroxytyrosol nicotinate, a new multifunctional hypolipidemic and hypoglycemic agent." Biomedicine & Pharmacotherapy 99 (March 2018): 715–24. http://dx.doi.org/10.1016/j.biopha.2018.01.123.

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16

Duan, Jianping, Dajiang Zhao та Guisheng Yang. "Fabrication of silver nanoparticles through reduction by ε-caprolactam without using protecting agent". RSC Adv. 4, № 54 (2014): 28765–68. http://dx.doi.org/10.1039/c4ra01675k.

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17

Liu, Feng, Lin Lin, Shu Sheng, et al. "A glutathione-depleting chemodynamic therapy agent with photothermal and photoacoustic properties for tumor theranostics." Nanoscale 12, no. 3 (2020): 1349–55. http://dx.doi.org/10.1039/c9nr09858e.

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18

Winter, Patrick M. "Perfluorocarbon Nanoparticles: Evolution of a Multimodality and Multifunctional Imaging Agent." Scientifica 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/746574.

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Perfluorocarbon nanoparticles offer a biologically inert, highly stable, and nontoxic platform that can be specifically designed to accomplish a range of molecular imaging and drug delivery functions in vivo. The particle surface can be decorated with targeting ligands to direct the agent to a variety of biomarkers that are associated with diseases such as cancer, cardiovascular disease, obesity, and thrombosis. The surface can also carry a high payload of imaging agents, ranging from paramagnetic metals for MRI, radionuclides for nuclear imaging, iodine for CT, and florescent tags for histology, allowing high sensitivity mapping of cellular receptors that may be expressed at very low levels in the body. In addition to these diagnostic imaging applications, the particles can be engineered to carry highly potent drugs and specifically deposit them into cell populations that display biosignatures of a variety of diseases. The highly flexible and robust nature of this combined molecular imaging and drug delivery vehicle has been exploited in a variety of animal models to demonstrate its potential impact on the care and treatment of patients suffering from some of the most debilitating diseases.

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19

Zhou, Shu-Mei, De-Kun Ma, Sheng-Hui Zhang, et al. "PEGylated Cu3BiS3 hollow nanospheres as a new photothermal agent for 980 nm-laser-driven photothermochemotherapy and a contrast agent for X-ray computed tomography imaging." Nanoscale 8, no. 3 (2016): 1374–82. http://dx.doi.org/10.1039/c5nr06041a.

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20

Castro, Alichandra, Manuel A. Martins, Liliana P. Ferreira, Margarida Godinho, Paula M. Vilarinho, and Paula Ferreira. "Multifunctional nanopatterned porous bismuth ferrite thin films." Journal of Materials Chemistry C 7, no. 25 (2019): 7788–97. http://dx.doi.org/10.1039/c9tc01174a.

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Nanopatterned porous thin films of bismuth ferrite (BiFeO<sub>3</sub>) with porosity perpendicular to the plane are prepared by an evaporation-induced self-assembly methodology using nitrate metal salts and a commercial block copolymer as a structure-directing agent.

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21

Cocco, Claudia, Nicola Giuliani, Emma Di Carlo, et al. "Interleukin-27 Acts as Multifunctional Antitumor Agent in Multiple Myeloma." Clinical Cancer Research 16, no. 16 (2010): 4188–97. http://dx.doi.org/10.1158/1078-0432.ccr-10-0173.

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22

Park, Kinam. "Poly-SNO-HSA: A safe and effective multifunctional antitumor agent." Journal of Controlled Release 164, no. 1 (2012): 105. http://dx.doi.org/10.1016/j.jconrel.2012.11.006.

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23

Yoon, Jiyoung, Sun Hang Cho, and Hasoo Seong. "Multifunctional ultrasmall superparamagnetic iron oxide nanoparticles as a theranostic agent." Colloids and Surfaces A: Physicochemical and Engineering Aspects 520 (May 2017): 892–902. http://dx.doi.org/10.1016/j.colsurfa.2017.02.080.

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24

Edwards, H. V., R. T. Cameron, and G. S. Baillie. "The emerging role of HSP20 as a multifunctional protective agent." Cellular Signalling 23, no. 9 (2011): 1447–54. http://dx.doi.org/10.1016/j.cellsig.2011.05.009.

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25

Chouhan, Raghuraj Singh, Milena Horvat, Jahangeer Ahmed, Norah Alhokbany, Saad M. Alshehri, and Sonu Gandhi. "Magnetic Nanoparticles—A Multifunctional Potential Agent for Diagnosis and Therapy." Cancers 13, no. 9 (2021): 2213. http://dx.doi.org/10.3390/cancers13092213.

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Magnetic nanoparticles gained considerable attention in last few years due to their remarkable properties. Superparamaganetism, non-toxicity, biocompatibility, chemical inertness, and environmental friendliness are some of the properties that make iron oxide nanoparticles (IONPs) an ideal choice for biomedical applications. Along with being easily tuneable and a tailored surface for conjugation of IONPs, their physio-chemical and biological properties can also be varied by modifying the basic parameters for synthesis that enhances the additional possibilities for designing novel magnetic nanomaterial for theranostic applications. This review highlights the synthesis, surface modification, and different applications of IONPs for diagnosis, imaging, and therapy. Furthermore, it also represents the recent report on the application of IONPs as enzyme mimetic compounds and a contrasting agent, and its significance in the field as an anticancer and antimicrobial agent.

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Chiesa, Enrica, Antonietta Greco, Rossella Dorati, et al. "Microfluidic-assisted synthesis of multifunctional iodinated contrast agent polymeric nanoplatforms." International Journal of Pharmaceutics 599 (April 2021): 120447. http://dx.doi.org/10.1016/j.ijpharm.2021.120447.

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27

Li, Ting, Yumei Mao, Yue Qi, Hongmei Zeng, Guohong Zou, and Zhien Lin. "Ionothermal synthesis of crystalline metal phosphites using multifunctional protic ionic liquids." CrystEngComm 22, no. 37 (2020): 6096–100. http://dx.doi.org/10.1039/d0ce01182g.

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28

Ng, CL, and WS Chow. "Multifunctional halloysite nanotube–reinforced polypropylene/polyamide binary nanocomposites." Polymers and Polymer Composites 28, no. 8-9 (2019): 623–30. http://dx.doi.org/10.1177/0967391119895441.

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This article highlights the potential of halloysite nanotube (HNT) as a multifunctional filler for polypropylene/polyamide 66 (PP/PA66) blends, for their roles as the reinforcing agent, compatibilizer, nucleating agent, and thermal stabilizer. The flexural modulus and strength of PP/PA66 were improved by the incorporation of HNT due to the reinforcing ability and compatibilization effects of HNT. 4 parts per hundred resin (phr) of HNT improved the thermal stability of PP/PA66 blends due to its heat barrier effects. Adding HNT increased the degree of crystallinity for PP and PA66, where the effects of HNT were more prominent in the PA66 phase, attributed to additional hydrogen bonding formation between the PA66 and HNT.

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Chen, Chao, Xiaofeng Guo, Jinhong Du, et al. "Synthesis of multifunctional miktoarm star polymers via an RGD peptide-based RAFT agent." Polymer Chemistry 10, no. 2 (2019): 228–34. http://dx.doi.org/10.1039/c8py01355a.

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30

Sun, Yue, Feng Ding, Zhao Chen, et al. "Melanin-dot–mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy." Proceedings of the National Academy of Sciences 116, no. 34 (2019): 16729–35. http://dx.doi.org/10.1073/pnas.1908761116.

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Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemo-photothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.

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Gao, Hong-Wen, Gang Xu, and Yue Wang. "From macropore to mesopore: diatomite reassembled into a multifunctional composite." RSC Adv. 4, no. 45 (2014): 23690–93. http://dx.doi.org/10.1039/c4ra01002g.

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A ‘dissolving first and then reassembling’ way was presented for preparing an SN@SiO<sub>2</sub> composite by the hybridization of an antistatic agent SN with diatomite. The colored antistatic agent was prepared by binding of the composite with a sulfonic dye. Also, it captured nonylphenol from wastewater, and the waste sludge produced was calcined to form mesoporous sieves.

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32

Walia, Shanka, and Amitabha Acharya. "Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy." Beilstein Journal of Nanotechnology 6 (February 24, 2015): 546–58. http://dx.doi.org/10.3762/bjnano.6.57.

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Nano-theranostics offer remarkable potential for future biomedical technology with simultaneous applications for diagnosis and therapy of disease sites. Through smart and careful chemical modifications of the nanoparticle surface, these can be converted to multifunctional tiny objects which in turn can be used as vehicle for delivering multimodal imaging agents and therapeutic material to specific target sites in vivo. In this sense, bimodal imaging probes that simultaneously enable magnetic resonance imaging and fluorescence imaging have gained tremendous attention because disease sites can be characterized quick and precisely through synergistic multimodal imaging. But such hybrid nanocomposite materials have limitations such as low chemical stability (magnetic component) and harsh cytotoxic effects (fluorescent component) and, hence, require a biocompatible protecting agent. Silica micro/nanospheres have shown promise as protecting agent due to the high stability and low toxicity. This review will cover a full description of MRI-active and fluorescent multifunctional silica micro/nanospheres including the design of the probe, different characterization methods and their application in imaging and treatment in cancer.

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Zou, Hong Yan, Jing Lan, and Cheng Zhi Huang. "Dopamine derived copper nanocrystals used as an efficient sensing, catalysis and antibacterial agent." RSC Advances 5, no. 69 (2015): 55832–38. http://dx.doi.org/10.1039/c5ra06240c.

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Pedrosa, Pedro, M. Luísa Corvo, Margarida Ferreira-Silva, et al. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles." International Journal of Molecular Sciences 20, no. 21 (2019): 5510. http://dx.doi.org/10.3390/ijms20215510.

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Resistance to chemotherapy is a major problem facing current cancer therapy, which is continuously aiming at the development of new compounds that are capable of tackling tumors that developed resistance toward common chemotherapeutic agents, such as doxorubicin (DOX). Alongside the development of new generations of compounds, nanotechnology-based delivery strategies can significantly improve the in vivo drug stability and target specificity for overcoming drug resistance. In this study, multifunctional gold nanoparticles (AuNP) have been used as a nanoplatform for the targeted delivery of an original anticancer agent, a Zn(II) coordination compound [Zn(DION)2]Cl2 (ZnD), toward better efficacy against DOX-resistant colorectal carcinoma cells (HCT116 DR). Selective delivery of the ZnD nanosystem to cancer cells was achieved by active targeting via cetuximab, NanoZnD, which significantly inhibited cell proliferation and triggered the death of resistant tumor cells, thus improving efficacy. In vivo studies in a colorectal DOX-resistant model corroborated the capability of NanoZnD for the selective targeting of cancer cells, leading to a reduction of tumor growth without systemic toxicity. This approach highlights the potential of gold nanoformulations for the targeting of drug-resistant cancer cells.

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Song, Yang, Qiurong Shi, Chengzhou Zhu, et al. "Mitochondrial-targeted multifunctional mesoporous Au@Pt nanoparticles for dual-mode photodynamic and photothermal therapy of cancers." Nanoscale 9, no. 41 (2017): 15813–24. http://dx.doi.org/10.1039/c7nr04881e.

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Wei, Guoqing, Yi Wang, Xuehui Huang, Guang Yang, Jingya Zhao, and Shaobing Zhou. "Induction of mitochondrial apoptosis for cancer therapy via dual-targeted cascade-responsive multifunctional micelles." Journal of Materials Chemistry B 6, no. 48 (2018): 8137–47. http://dx.doi.org/10.1039/c8tb02159g.

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Fanizza, E., R. M. Iacobazzi, V. Laquintana, et al. "Highly selective luminescent nanostructures for mitochondrial imaging and targeting." Nanoscale 8, no. 6 (2016): 3350–61. http://dx.doi.org/10.1039/c5nr08139d.

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Kotagiri, Nalinikanth, Joshua Sakon, Haewook Han, Vladimir P. Zharov, and Jin-Woo Kim. "Fluorescent ampicillin analogues as multifunctional disguising agents against opsonization." Nanoscale 8, no. 25 (2016): 12658–67. http://dx.doi.org/10.1039/c5nr08686h.

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A multifunctional fluorescent derivative of a beta-lactam antibiotic, ampicillin (termed iAmp) shows high promise as a biocompatible shielding agent and an effective dispersant for improving the in vivo effectiveness of theranostic nanomaterials.

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Hebert, Wesley, Antonio DiGiandomenico, and Michael Zegans. "Multifunctional Monoclonal Antibody Targeting Pseudomonas aeruginosa Keratitis in Mice." Vaccines 8, no. 4 (2020): 638. http://dx.doi.org/10.3390/vaccines8040638.

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A worrisome trend in the study and treatment of infectious disease noted in recent years is the increase in multidrug resistant strains of bacteria concurrent with a scarcity of new antimicrobial agents to counteract this rise. This is particularly true amongst bacteria within the Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE) designation. P. aeruginosa is one of the most common causes of bacterial keratitis. Therefore, it is of vital importance to characterize new antimicrobial agents with anti-Pseudomonal activity for use with the ocular surface. MEDI3902 is a multifunctional antibody that targets the P. aeruginosa persistence factor Psl exopolysaccharide, and the type 3 secretion protein PcrV. We initially assessed this antibody for ocular surface toxicity. The antimicrobial activity of the antibody was then tested by treating mice with established P. aeruginosa keratitis with both topical and intravenous treatment modalities. MEDI3902, was shown to be non-toxic to the ocular surface of mice when given topically. It was also effective compared to the control antibody at preventing P. aeruginosa keratitis with a one-time treatment at the time of infection. Both topical and intravenous administration of MEDI3902 has been proved significant in treating established keratitis infections as well, speeding the resolution of infection significantly more than that of the control IgG. We report the first use of a topical immunotherapeutic multifunctional agent targeting Psl and type 3 secretion on the ocular surface as an antimicrobial agent. While MEDI3902 has been shown to prevent Pseudomonas biofilm formation in keratitis models when given prophylactically intravitally, we show that MEDI3902 has the capability to also treat an active infection when given intravenously to mice with Pseudomonas keratitis. Our data indicate antibodies are well tolerated and nontoxic on the ocular surface. They reduce infection in mice treated concurrently at inoculation and reduced the signs of cornea pathology in mice with established infection. Taken together, these data indicate treatment with monoclonal antibodies directed against Psl and PcrV may be clinically effective in the treatment of P. aeruginosa keratitis and suggest that the design of further antibodies to be an additional tool in the treatment of bacterial keratitis.

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Ye, Rui-Rong, Cai-Ping Tan, Yan-Nan Lin, Liang-Nian Ji, and Zong-Wan Mao. "A phosphorescent rhenium(i) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction." Chemical Communications 51, no. 39 (2015): 8353–56. http://dx.doi.org/10.1039/c5cc02354h.

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A phosphorescent rhenium(i) tricarbonyl polypyridine complex with mitochondria-specific localization, HDAC inhibitory activity and paraptosis-inducing capability has been explored as a multifunctional agent.

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Zou, Yongkun, Jingwei He, Zhenghai Tang, Lixin Zhu, Yuanfang Luo, and Fang Liu. "Effect of multifunctional samarium lysine dithiocarbamate on curing properties, static and dynamic mechanical properties of SBR/silica composites." RSC Advances 6, no. 1 (2016): 269–80. http://dx.doi.org/10.1039/c5ra21106a.

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42

Zhang, Yichuan, Alessia Gambardella, Muhammed Üçüncü, et al. "Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification." Chemical Communications 56, no. 89 (2020): 13856–59. http://dx.doi.org/10.1039/d0cc04591h.

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A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled simple purification of polymer–protein conjugates.

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Shukla, Jaya, and BhagwantRai Mittal. "Dimercaptosuccinic acid: A multifunctional cost effective agent for imaging and therapy." Indian Journal of Nuclear Medicine 30, no. 4 (2015): 295. http://dx.doi.org/10.4103/0972-3919.164015.

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Wang, Xi. "Dynamic Mechanical Properties of Epoxy Resin with Multifunctional Polyamine Curing Agent." Applied Mechanics and Materials 744-746 (March 2015): 1374–77. http://dx.doi.org/10.4028/www.scientific.net/amm.744-746.1374.

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A nonlinear multifunctional polyamine N,N,N’,N’-tetra (3-aminopropyl)-1,6-diamino-hexane (TADH), was prepared and employed as a novel hardener for diglycidyl ether of bisphenol A (DGEBA). Nonisothermal reactions of DGEBA/TADH were systematically investigated with differential scanning calorimetry (DSC). In addition, analysis of thermal stability of the cured DGEBA/TADH with thermogravimetric analysis (TGA) revealed that it possessed quite good thermal stability and increased residual char content at 600◦C in nitrogen. Furthermore, dynamic mechanical analysis (DMA) of the DGEBA/TADH network showed its relaxations were characterized by localized motions of hydroxyl ether segments and cooperative motions of whole network chains (glass relaxation) at different temperature regions.

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Garcia, Patrícia Salomão, Maria Victória Eiras Grossmann, Fábio Yamashita, Suzana Mali, Luiz Henrique Dall'Antonia, and Wagner José Barreto. "Citric acid as multifunctional agent in blowing films of starch/PBAT." Química Nova 34, no. 9 (2011): 1507–10. http://dx.doi.org/10.1590/s0100-40422011000900005.

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Li, Xun, Ying Liu, Jinwen Ye, Xuguang An, and Huaying Ran. "Multifunctional foaming agent to prepare aluminum foam with enhanced mechanical properties." Materials Research Express 5, no. 3 (2018): 036529. http://dx.doi.org/10.1088/2053-1591/aaad8d.

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Tian, Tengfei, Xiaoze Shi, Liang Cheng, et al. "Graphene-Based Nanocomposite As an Effective, Multifunctional, and Recyclable Antibacterial Agent." ACS Applied Materials & Interfaces 6, no. 11 (2014): 8542–48. http://dx.doi.org/10.1021/am5022914.

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Gao, Jinhao, Gaolin Liang, Jerry S. Cheung, et al. "Multifunctional Yolk−Shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent." Journal of the American Chemical Society 130, no. 35 (2008): 11828–33. http://dx.doi.org/10.1021/ja803920b.

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Esmaielzade Rostami, Mahshid, Banafsheh Gorji, and Reza Zadmard. "Calix[4]arene-based Multifunctional Ligand as Potent Protein Binding Agent." Journal of Heterocyclic Chemistry 55, no. 11 (2018): 2532–37. http://dx.doi.org/10.1002/jhet.3299.

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Vultos, Filipe, Célia Fernandes, Filipa Mendes, et al. "A Multifunctional Radiotheranostic Agent for Dual Targeting of Breast Cancer Cells." ChemMedChem 12, no. 14 (2017): 1103–7. http://dx.doi.org/10.1002/cmdc.201700287.

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