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Journal articles on the topic 'Multiplate aggregometry'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Vertessen, Francine, Gerhard Mertens, Alain Gadisseur, Marc Van der Planken, and Jaimie Breugelmans. "Multiplate whole blood impedance aggregometry: A recent experience." Thrombosis and Haemostasis 100, no. 10 (2008): 725–26. http://dx.doi.org/10.1160/th08-07-0438.

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2

Pedersen, Susanne B., Erik L. Grove, Helle L. Nielsen, Jette Mortensen, Steen D. Kristensen, and Anne-Mette Hvas. "Evaluation of aspirin response by Multiplate® whole blood aggregometry and light transmission aggregometry." Platelets 20, no. 6 (2009): 415–20. http://dx.doi.org/10.1080/09537100903100643.

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3

Soliman, Mohamed, and Matthias Hartmann. "Multiplate® Platelet Aggregation Findings Are Dependent on Platelet Count but Can Be Corrected by Use of a Ratio." Applied Sciences 10, no. 22 (2020): 7971. http://dx.doi.org/10.3390/app10227971.

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Impedance aggregometry (Multiplate®) detects the effects of platelet aggregation inhibitors and can predict thrombotic complications after coronary and cerebrovascular stent interventions. The bedside method uses whole blood samples not corrected for platelet count. It is claimed but not proved that the findings are unrelated to platelet count in the physiological range. We therefore investigated in the experimental study: (1) whether impedance aggregometry findings and platelet count are correlated and (2) whether the aggregation/platelet count ratio expresses platelet function independent of

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4

Petrova, О. V., S. А. Shashin, and D. G. Tarasov. "Reference Values of Platelet Aggregation in Impedance Aggregometry with Adenosine Diphosphoric Acid on Aggregometer Multiplate." Sovremennye tehnologii v medicine 8, no. 3 (2016): 100–104. http://dx.doi.org/10.17691/stm2016.8.3.11.

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5

Karon, Brad S., Nicole V. Tolan, Christopher D. Koch, et al. "Precision and Reliability of 5 Platelet Function Tests in Healthy Volunteers and Donors on Daily Antiplatelet Agent Therapy." Clinical Chemistry 60, no. 12 (2014): 1524–31. http://dx.doi.org/10.1373/clinchem.2014.226332.

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Abstract BACKGROUND Anticoagulation protocols used during mechanical circulatory support call for titration of antiplatelet agents. We compared the precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet therapy to distinguish their efficacy for titrating antiplatelet therapy. METHODS We assessed arachidonic acid–induced platelet function by light transmission aggregometry (LTA), Multiplate impedance aggregometry, VerifyNow, and platelet mapping by thromboelastography (TEG PM). We assessed ADP-induced platelet function by the same methods a

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6

Hummel, Thomas, Saskia Hannah Meves, Andreas Breuer-Kaiser, et al. "Perioperative changes of response to antiplatelet medication in vascular surgery patients." PLOS ONE 15, no. 12 (2020): e0244330. http://dx.doi.org/10.1371/journal.pone.0244330.

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Introduction Reduced antiplatelet activity of aspirin (ALR) or clopidogrel (CLR) is associated with an increased risk of thromboembolic events. The reported prevalence data for low-responders vary widely and there have been few investigations in vascular surgery patients even though they are at high risk for thromb-embolic complications. The aim of this prospective observational monocentric study was to elucidate possible changes in ALR or CLR after common vascular procedures. Methods Activity of aspirin and clopidogrel was measured by impedance aggregometry using a multiple electrode aggregom

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7

Hamouda, Khaled, Sebastian Sommer, Mehmet Özkur, Johannes Hain, Rainer Leyh, and Christoph Schimmer. "The Predictive Value of Multiple Electrode Platelet Aggregometry (Multiplate) in Adult Cardiac Surgery." Thoracic and Cardiovascular Surgeon 61, no. 08 (2013): 733–43. http://dx.doi.org/10.1055/s-0033-1333659.

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8

Thalén, Simon, Ida Forsling, Jaak Eintrei, Lisbeth Söderblom, and Jovan P. Antovic. "Pneumatic tube transport affects platelet function measured by multiplate electrode aggregometry." Thrombosis Research 132, no. 1 (2013): 77–80. http://dx.doi.org/10.1016/j.thromres.2013.04.020.

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9

Lee, Kurtis R., Veerle J. E. Verheyden, and Andrew D. Mumford. "Evaluation of multiple electrode aggregometry in whole blood using Multiplate® Mini Test cells." Thrombosis Research 129, no. 4 (2012): e59-e64. http://dx.doi.org/10.1016/j.thromres.2011.12.032.

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10

Femia, E. A., M. Scavone, A. Lecchi, and M. Cattaneo. "Effect of platelet count on platelet aggregation measured with impedance aggregometry (Multiplate™ analyzer) and with light transmission aggregometry." Journal of Thrombosis and Haemostasis 11, no. 12 (2013): 2193–96. http://dx.doi.org/10.1111/jth.12432.

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11

Stissing, Trine, Nadia P. Dridi, Sisse R. Ostrowski, Louise Bochsen, and Pär I. Johansson. "The Influence of Low Platelet Count on Whole Blood Aggregometry Assessed by Multiplate." Clinical and Applied Thrombosis/Hemostasis 17, no. 6 (2011): E211—E217. http://dx.doi.org/10.1177/1076029610397183.

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The Multiplate, a whole blood (WB) platelet function test, has shown promising results identifying patients on antiplatelet therapy at increased risk of rethrombosis. In the present study, the influence of low platelet count on platelet aggregation was analyzed and compared with aggregation results in an artificial matrix, platelet-rich plasma (PRP). Heparinized and citrated blood was diluted with autologous plasma to platelet concentrations 200 to 25 × 109/L in WB samples (n = 10) and 200 to 100 × 109/L in PRP samples (n = 7). The platelet aggregation was investigated by the ADP-, ASPI-, COL-

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12

Braun, Siegmund, Stefan Jawansky, Wolfgang Vogt, et al. "Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment." Thrombosis and Haemostasis 99, no. 01 (2008): 121–26. http://dx.doi.org/10.1160/th07-07-0478.

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SummaryThe level of platelet aggregation, measured with light transmission aggregometry (LTA) in platelet rich plasma (PRP), has been shown to predict outcomes after percutaneous coronary intervention (PCI). However, measuring parameters of platelet function with LTA is time consuming and weakly standardized. Thus, a fast and standardized method to assess platelet function after clopidogrel treatment would be of great value for clinical practice. A new method, multiple electrode platelet aggregometry (MEA), to rapidly measure platelet aggregation in whole blood has recently been developed. The

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13

VALARCHE, V., C. DESCONCLOIS, T. BOUTEKEDJIRET, M. DREYFUS, and V. PROULLE. "Multiplate whole blood impedance aggregometry: a new tool for von Willebrand disease." Journal of Thrombosis and Haemostasis 9, no. 8 (2011): 1645–47. http://dx.doi.org/10.1111/j.1538-7836.2011.04400.x.

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14

Mărginean, Alina, Valeriu Moldovan, and Mihai Mărginean. "High-on-Aspirin Residual Platelet Reactivity Evaluated Using the Multiplate® Point-of-Care Device." Acta Medica Marisiensis 62, no. 1 (2016): 101–5. http://dx.doi.org/10.1515/amma-2015-0124.

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AbstractObjective: The aim of this study was to evaluate the prevalence of aspirin non-responsiveness using whole blood multiple electrode aggregometry and to investigate the role of different clinical and laboratory variables associated with the lack of response. Methods: The present study included 116 aspirin treated patients presented with acute coronary syndromes or stroke. Response to aspirin was assessed by impedance aggregometry using arachidonic acid as agonist, in a final concentration of 0.5 mM (ASPI test). Results: In our data set 81% (n=94) were responders and 19% (n=22) non-respon

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15

Spannagl, Michael, and Csilla Jambor. "Baseline Platelet Reactivity as Determined by TRAP-6 Induced Aggregation in Whole Blood Is Related to the Rate of Non-Responsiveness to Clopidogrel." Blood 112, no. 11 (2008): 5362. http://dx.doi.org/10.1182/blood.v112.11.5362.5362.

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Abstract Background: Platelet inhibition by clopidogrel is often determined using ADP induced aggregometry. TRAP-6 stimulates platelets via the PAR receptors and is influenced to a much lesser extend by aspirin or clopidogrel. The value of the determination of TRAP-6 induced aggregometry in patients treated with clopidogrel is unknown. We evaluated the relation of clopidogrel non-responsiveness as determined by multiple electrode aggregometry (MEA) (1) vs. TRAP-6 induced aggregation. MEA provides a measurement of platelet aggregation in whole blood by monitoring changes in electrical impedance

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16

Bélanger, Jean-Christophe, Fabio Luiz Bandeira Ferreira, Mélanie Welman, et al. "Head-to-Head Comparison of Consensus-Recommended Platelet Function Tests to Assess P2Y12 Inhibition—Insights for Multi-Center Trials." Journal of Clinical Medicine 9, no. 2 (2020): 332. http://dx.doi.org/10.3390/jcm9020332.

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The vasodilator-associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted to specialized laboratories. Recently, a simple ELISA kit has been commercialized. The primary objective of this study was to compare the performance of VASP assessment by ELISA and flow cytometry in relation to functional platelet aggregation testing by Multiplate® whole-blood aggregometry. Blood from 24 healthy volunteers was incubated with increas

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Antic, Ana, Zoran Stanojkovic, Miodrag Vucic, Milan Lazarevic, and Nebojsa Vacic. "Comparison of farmacodynamic properties of three different aspirin formualtions in patients with stable coronary disease." Vojnosanitetski pregled 76, no. 6 (2019): 628–34. http://dx.doi.org/10.2298/vsp180110034a.

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Background/Aim. The platelet aggregation, as a laboratory test for assessment of platelet function, is very efficient for optimal antiplatelet treatment and also to identify individuals who have suboptimal response to antiplatelet drugs, such as aspirin and clopidogrel. The aim of this study was to determine the level of inhibition of platelet aggregation using impedance aggregometry in the patients receiving different preparations of acetylsalicylic acid (ASA) in a dose of 100 mg per day. Methods. The examination included 215 patients (110 men and 105 women), treated with one of three differe

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18

Dugan, Greg, Lisa O’Donnell, David B. Hanbury, J. Mark Cline, and David L. Caudell. "Assessment of Multiplate platelet aggregometry using citrate, heparin or hirudin in Rhesus macaques." Platelets 26, no. 8 (2014): 730–35. http://dx.doi.org/10.3109/09537104.2014.988694.

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19

Cabañas, Valentin, Juan Jose Cerezo-Manchado, Faustino Garcia-Candel, et al. "Decrease of Aggregation By Platelet Impedance Aggregometry ( MULTIPLATE ) in Patients Treated with Dabigatran." Blood 128, no. 22 (2016): 5022. http://dx.doi.org/10.1182/blood.v128.22.5022.5022.

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Abstract Introduction: Dabigatran is a direct oral anticoagulant (DOAC) that has been proved effective and safe in preventing thromboembolic events experienced by patients with non-valvular atrial fibrillation (AF). This drug acts directly inhibiting thrombin and particularly affects the intrinsic and the final coagulation pathways. Thrombin is a platelet agonist therefore dabigatran could be involved in altering the aggregation. However, it is not well known whether they modify the platelet function. We conducted an initial study in our hospital to assess platelet aggregation in patients trea

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20

Calatzis, Andreas, Franz Theisen, Armin J. Reininger, and Michael Spannagl. "Monitoring of Clopidogrel Using Multiple Electrode Aggregometry." Blood 108, no. 11 (2006): 883. http://dx.doi.org/10.1182/blood.v108.11.883.883.

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Abstract A control of clopidogrel response is one proposed strategy for an improvement of anti-platelet therapy. Different methods have been evaluated for this indication. We assessed ADP induced aggregation in whole blood in healthy blood donors and patients treated with clopidogrel 75 mg qd using a new monitoring method. Methods: Platelet function was determined using multiple electrode aggregometry (MEA) on the Multiplate analyzer (Dynabyte, Munich, Germany). This device uses a single use test cell with two separate impedance sensors, consisting of a total of 4 electrodes and has 5 channels

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Khadim, Murad A., Hasan A. Farhan, Muthanna ., and Muthanna H. Al-Quraishi. "Clopidogrel Responsiveness in Patients Undergoing Percutaneous Coronary Intervention using Multiplate Analyzer: Frequency and Outcomes." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 1112–16. http://dx.doi.org/10.25258/ijddt.13.3.53.

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Objectives: Over and under response to dual antiplatelet therapy (DAPT) can lead to bleeding and thrombotic events in patients undergoing coronary stent placement. The present study aimed to assess the platelet response to clopidogrel in patient undergoing percutaneous coronary intervention (PCI) using Multiplate Analyzer. The primary outcome in the present study was the short-term incidence of stent thrombosis and bleeding events. Background: Multiple electrode aggregometry is a rapid and standardized tool to for diagnosis of platelet defects and monitoring response to DAPT. Methods: A hospit

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22

Taher, Qasim Mohammed, Khalid Amber, and Ahmed N. Rgeeb. "Assessment of platelet reactivity with anti platelet agent (clopidogrel) after two drugs formulation PLAVIX® and PLAGERINE." Kufa Journal for Nursing Sciences 2, no. 3 (2012): 36–42. http://dx.doi.org/10.36321/kjns.vi20123.2535.

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Cardiovascular disease remains the main cause of mortality. Antiplatelet therapy is the main drug use in the management of coronary artery disease. Several million of people received colpidogril, however the cost of the drug that might 3-4 dollars daily for the brand company Sanofi. pharmacies start to sell cheaper generic in Indian origin. assessment of platelet function after two drugs (Plavix and plagrine) by multiple electrode platelet aggregometry (MEA) shows no difference of both drugs on the multiplate activity, this is assessed by prospective cross sectional study included 28 patients

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23

Flechtenmacher, N., F. Kämmerer, R. Dittmer, et al. "Clopidogrel Resistance in Neurovascular Stenting: Correlations between Light Transmission Aggregometry, VerifyNow, and the Multiplate." American Journal of Neuroradiology 36, no. 10 (2015): 1953–58. http://dx.doi.org/10.3174/ajnr.a4388.

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24

Pikta, M., L. J. Mettis, K. Rahuoja, T. Helin, S. Saulyte Trakymiene, and V. Banys. "Verification of reference values for multiplate impedance aggregometry analyzer: A call for international cooperation." Clinica Chimica Acta 558 (May 2024): 118371. http://dx.doi.org/10.1016/j.cca.2024.118371.

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25

Roka-Moiia, Yana, Silvia Bozzi, Chiara Ferrari, et al. "The MICELI (MICrofluidic, ELectrical, Impedance): Prototyping a Point-of-Care Impedance Platelet Aggregometer." International Journal of Molecular Sciences 21, no. 4 (2020): 1174. http://dx.doi.org/10.3390/ijms21041174.

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As key cellular elements of hemostasis, platelets represent a primary target for thrombosis and bleeding management. Currently, therapeutic manipulations of platelet function (antithrombotic drugs) and count (platelet transfusion) are performed with limited or no real-time monitoring of the desired outcome at the point-of-care. To address the need, we have designed and fabricated an easy-to-use, accurate, and portable impedance aggregometer called “MICELI” (MICrofluidic, ELectrical, Impedance). It improves on current platelet aggregation technology by decreasing footprint, assay complexity, an

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26

Desconclois, Celine, Vincent Valarche, Tewfik Boutekedjiret, Martine Raphael, Marie Dreyfus, and Valerie Proulle. "Whole Blood Impedance Aggregometry: A New Tool for Severe Inherited Platelet Disorder Diagnosis?" Blood 118, no. 21 (2011): 5266. http://dx.doi.org/10.1182/blood.v118.21.5266.5266.

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Abstract Abstract 5266 Diagnosis and characterization of platelet function disorders may be challenging. It requires multiple laboratory data including the assessment of platelet functions. Platelet function analysis is most commonly performed using light transmission aggregometry (LTA). LTA is a time-consuming method requiring centrifugation steps and large blood volumes. It is difficult to perform in children and in cases of thrombocytopenia. In contrast, platelet aggregation in whole blood using impedancemetry (WBI) is a fast method, allows omission of centrifugation steps and performance o

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Schmidt, David E., Maria Bruzelius, Ammar Majeed, Jacob Odeberg, Margareta Holmström, and Anna Ågren. "Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease." Thrombosis and Haemostasis 117, no. 08 (2017): 1528–33. http://dx.doi.org/10.1160/th17-02-0129.

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SummaryVon Willebrand disease (VWD) is the most common bleeding disorder, but no bedside tests specific for Von Willebrand factor are available. The objective of this study was to evaluate the diagnostic accuracy of whole blood ristocetin-induced platelet aggregometry (WB-RIPA) in VWD. WB-RIPA was performed in VWD patients (n=100) and healthy controls (n=17) using the Multiplate® platelet impedance aggregometry platform. The diagnostic properties of the test were described as sensitivity/specificity, positive and negative predictive value, and ROC area under the curve (AUC). Patients with VWD

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Blomqvist, L., A. Strandell, F. Baghaei, and M. Hellgren. "P-034: Multiple impedance aggregometry (Multiplate®) in healthy women during normal pregnancy – a prospective and longitudinal study." Thrombosis Research 151 (March 2017): S120. http://dx.doi.org/10.1016/s0049-3848(17)30132-9.

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Pedersen, Susanne B., Steen D. Kristensen, and Anne-Mette Hvas. "Measurement of Whole Blood Platelet Aggregation by Multiplate® Aggregometry Before and during Aspirin Treatment." Blood 110, no. 11 (2007): 3895. http://dx.doi.org/10.1182/blood.v110.11.3895.3895.

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Abstract The inhibition of platelet aggregation by aspirin (ASA) is fundamental in treatment of ischemic heart disease (IHD). Several studies report findings of normal platelet aggregation despite ASA treatment in some individuals, referred to as ASA resistance (AR). It has been hypothesized that AR increases the risk of a future ischemic event. We evaluated a new impedance method for measurement of platelet aggregation, Multiplate® aggregometry (MA), and compared this method to light aggregometry ad modum Born (OPA), with reference to repeatability and detection of AR. Blood samples from 43 I

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Minde, Jan-Wighard, and Reinhard Mischke. "Influence of sample storage on impedance aggregometry measured using the Multiplate® analyser in dogs." Comparative Clinical Pathology 23, no. 5 (2013): 1403–7. http://dx.doi.org/10.1007/s00580-013-1797-2.

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Kuliczkowski, Wiktor, Dan Atar, Victor Serebruany, and Dániel Aradi. "Inter-patient variability and impact of proton pump inhibitors on platelet reactivity after prasugrel." Thrombosis and Haemostasis 107, no. 02 (2012): 338–45. http://dx.doi.org/10.1160/th11-09-0622.

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SummaryAlthough there is considerable variability of platelet reactivity among patients treated with clopidogrel, little is known about inter-individual differences and possible role of proton pump inhibitors (PPIs) after prasugrel. We defined the extent of inter-patient variability, and evaluated the impact of PPI interaction in prasugrel-treated patients with acute coronary syndrome (ACS). Between January 2010 and May 2011, 104 prospective, high-risk patients with ACS were recruited into this multicentre, prospective, observational study. Twelve to 24 hours after receiving 60 mg loading dose

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Larsen, Sanne, Erik Grove, Steen Kristensen, Søs Neergaard-Petersen, and Anne-Mette Hvas. "Increased platelet aggregation and serum thromboxane levels in aspirin-treated patients with prior myocardial infarction." Thrombosis and Haemostasis 108, no. 07 (2012): 140–47. http://dx.doi.org/10.1160/th12-01-0026.

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SummaryThe antiplatelet effect of aspirin displays considerable inter-individual variability. We investigated the antiplatelet effect of aspirin in patients with coronary artery disease on aspirin mono-therapy with and without prior myocardial infarction (MI). Further, we investigated whether the effect of aspirin differed between patients with and without aspirin use at the time of MI onset. We performed a study on 231 patients, including 171 with prior MI. Among patients with only one prior MI (116 patients), 59 patients were on aspirin at the time of MI onset. All patients received 75 mg as

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Kam, P. C. A., J. P. C. Liou, and K. X. F. Yang. "In Vitro Evaluation of the Effect of Haemodilution with Dextran 40 on Coagulation Profile as Measured by Thromboelastometry and Multiple Electrode Aggregometry." Anaesthesia and Intensive Care 45, no. 5 (2017): 562–68. http://dx.doi.org/10.1177/0310057x1704500506.

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We evaluated the effects of haemodilution with either dextran 40 or 0.9% normal saline on coagulation in vitro using rotational thromboelastometry (ROTEM®, Pentapharm Co., Munich, Germany) and multiple electrode aggregometry (Multiplate® Platelet Function Analyser, Dynabyte, Munich, Germany). Venous blood samples obtained from 20 healthy volunteers were diluted in vitro with dextran 40 or normal saline by 5%, 10% and 15%. Fibrinogen concentration, ROTEM-EXTEM® (screening test for the extrinsic coagulation pathway), FIBTEM® (an EXTEM-based assay of the fibrin component of clot) parameters inclu

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Spannagl, Michael, Andrea Dick, and Andreas Calatzis. "Comprehensive Quality Management of Multiple Electrode Platelet Aggregometry." Blood 114, no. 22 (2009): 4463. http://dx.doi.org/10.1182/blood.v114.22.4463.4463.

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Abstract Abstract 4463 Platelet function analysis provides quantitative results which may reveal platelet disorders, platelet inhibition during anti-platelet therapy or anti-platelet drug resistance. The results may have important consequences on patients therapy. As in all laboratory methods, a comprehensive quality management approach is crucial and increasingly demanded by regulatory authorities. In platelet function methods quality control is hampered by the fact that platelets are not stable over longer time periods and loose their functional activities after freezing and freeze-drying. T

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Krekels, Joyce P. M., Paul W. M. Verhezen, and Yvonne M. C. Henskens. "Platelet Aggregation in Healthy Participants is Not Affected by Smoking, Drinking Coffee, Consuming a High-Fat Meal, or Performing Physical Exercise." Clinical and Applied Thrombosis/Hemostasis 25 (June 19, 2018): 107602961878244. http://dx.doi.org/10.1177/1076029618782445.

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Platelet aggregation can be measured using optical aggregation (light transmission aggregometry, LTA) as well as by impedance (Multiplate analyzer). The LTA (the gold standard method) can be influenced by many preanalytical variables. Several guidelines differ in recommendations for the duration patients should refrain from smoking, coffee, fatty meals, and physical exercise prior to blood collection for performing platelet function tests. In this pilot study, the influence of smoking, coffee, high-fat meal, or physical exercise on platelet aggregation was investigated to improve patient frien

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Campello, Elena, Luca Spiezia, Eva Zabeo, Sara Maggiolo, Roberto Vettor, and Paolo Simioni. "Hypercoagulability detected by whole blood thromboelastometry (ROTEM®) and impedance aggregometry (MULTIPLATE®) in obese patients." Thrombosis Research 135, no. 3 (2015): 548–53. http://dx.doi.org/10.1016/j.thromres.2015.01.003.

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Jastrzębska, Maria, Kornel Chełstowski, Aneta Wódecka, Aldona Siennicka, Jeremy Clark, and Przemysław Nowacki. "Factors influencing Multiplate whole blood Impedance Platelet Aggregometry measurements, during aspirin treatment in acute ischemic stroke." Blood Coagulation & Fibrinolysis 24, no. 8 (2013): 830–38. http://dx.doi.org/10.1097/mbc.0b013e3283655640.

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Seyfert, Ulrich Theo, Hannelore Haubelt, Anette Vogt, and Peter Hellstern. "Variables influencing Multiplate™ whole blood impedance platelet aggregometry and turbidimetric platelet aggregation in healthy individuals." Platelets 18, no. 3 (2007): 199–206. http://dx.doi.org/10.1080/09537100600944277.

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39

Scaravilli, Vittorio, Luca Di Girolamo, Eleonora Scotti, et al. "Effects of sodium citrate, citric acid and lactic acid on human blood coagulation." Perfusion 33, no. 7 (2018): 577–83. http://dx.doi.org/10.1177/0267659118777441.

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Introduction: Citric acid infusion in extracorporeal blood may allow concurrent regional anticoagulation and enhancement of extracorporeal CO2 removal. Effects of citric acid on human blood thromboelastography and aggregometry have never been tested before. Methods: In this in vitro study, citric acid, sodium citrate and lactic acid were added to venous blood from seven healthy donors, obtaining concentrations of 9 mEq/L, 12 mEq/L and 15 mEq/L. We measured gas analyses, ionized calcium (iCa++) concentration, activated clotting time (ACT), thromboelastography and multiplate aggregometry. Repeat

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Jaitner, Juliane, Julia Stegherr, Tanja Morath, et al. "Stability of the high on-treatment platelet reactivity phenotype over time in clopidogrel-treated patients." Thrombosis and Haemostasis 105, no. 01 (2011): 107–12. http://dx.doi.org/10.1160/th10-07-0440.

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SummaryInterindividual response variability to clopidogrel treatment is a well established phenomenon. In recent studies and ongoing large-scale trials where patients with high on-treatment platelet reactivity (HPR) to clopidogrel are being randomised to an intensified antiplatelet treatment, confirmation of the HPR phenotype is based on one single platelet function assessment. The stability of the HPR phenotype over time has never been investigated but should be considered crucial for justification of intensified antiplatelet treatment regimens beyond clinical trials. The goal of this study w

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Sut, Agnieszka, Marcin Różalski, Jacek Golański, Maria Pytel, and Marek Zadrożny. "A polyphenol-rich diet is associated with decreased platelet aggregation in breast cancer patients." Diagnostyka Laboratoryjna 54, no. 2 (2019): 81–84. http://dx.doi.org/10.5604/01.3001.0013.7683.

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It is well documented that plant polyphenols have both anti-cancer and anti-platelet effects. Hence, the aim of this work was to investigate a relationship between dietary intake of polyphenols and platelet aggregation in newly-diagnosed breast cancer patients. The nutritional value of a diet, including dietary intake of plant polyphenols was estimated. Platelet aggregation was induced with arachidonic acid (0.5 mmol/l), collagen (3.2 μg/ml) or ADP (6.4 μmol/l) and measured using multiple electrode aggregometry (Multiplate<sup>®</sup>) in whole blood. It was found that platelet agg

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Rother, Daniel, Andreas Böning, and Johannes Gehron. "Der Einfluss der moderaten Hypothermie bei 28 °C auf die Gerinnungs- und Thrombozytenfunktion – Untersuchung in einem In-vitro-Chandler-Loop-Modell." Kardiotechnik 30, no. 2 (2021): 60–67. http://dx.doi.org/10.47624/kt.030.060.

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In the use of hypothermia in cardiac surgery an increased risk of bleeding is noticeable intra- and postoperatively. So far, the effects on coagulation and platelets caused by complex interactions between the extracorporeal circulation (ECC), surgical trauma and the effects of hypothermia prevent a clinical investigation of the cause of hypothermia associated bleeding in cardiac surgery. Methods: Using a Chandler-Loop blood flow model the effects of hypothermia could be studied under in-vitro conditions isolated from other competing factors. In the experimental group blood samples of three adu

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Pronko, T. P., V. A. Snezhitskiy, and A. V. Kapytski. "Platelet reactivity clinical and biochemical markers when taking acetylsalicylic acid as part of dual antiplatelet therapy in the myocardial infarction subacute period." Rational Pharmacotherapy in Cardiology 20, no. 6 (2024): 618–24. https://doi.org/10.20996/1819-6446-2024-3037.

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Aim. To study markers that determine residual platelet reactivity in the subacute period of myocardial infarction (MI) during the administration of acetylsalicylic acid (ASA) as part of dual antiplatelet therapy.Material and methods. 405 patients with MI (79.5% men and 20.5% women, average age 58.0 years) were divided into groups based on aggregometry results. Group 1 — 11 patients with low residual platelet reactivity, group 2 — 236 patients with optimal platelet reactivity, group 3 — 158 patients with high residual platelet reactivity (HRPR). All studies were performed on days 12-14 after MI

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Bonell, Vera, Christoph Schmaderer, Georg Lorenz, et al. "Ex Vivo Thrombocyte Function and Its Response to NO/Sildenafil in Patients Undergoing Hemodialysis." Journal of Clinical Medicine 14, no. 14 (2025): 5156. https://doi.org/10.3390/jcm14145156.

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Background: Coagulation disorders, including both bleeding and thrombotic complications, are common in patients undergoing hemodialysis (HD). Here, we aimed to characterize platelet function in patients undergoing hemodialysis three times per week, compared to healthy controls. Methods: Platelet function was assessed using the Multiplate analyzer (Roche), which is based on multiple electrode impedance aggregometry. Platelet aggregation was induced using adenosine diphosphate (ADP), and the area under the curve (AUC) served as the primary endpoint. In addition, platelet counts and C-reactive pr

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Ankri, Annick, Isabelle Martin-Toutain, Anne Baranger, Marie-Claude Couty, Jean Philippe Collet, and Gilles Montalescot. "Evaluation of Residual Platelet Reactivity in Patients Treated with Aspirin and or Clopidogrel: Comparison of Results Obtained On Multiplate®, PFA-100TM and Classical Light Transmission Aggregometry." Blood 114, no. 22 (2009): 3129. http://dx.doi.org/10.1182/blood.v114.22.3129.3129.

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Abstract Abstract 3129 Poster Board III-66 Residual platelet reactivity (RPR), despite antiplatelet therapy (AT), is currently associated with an increased risk of recurrent ischemic events and is linked to a biological resistance to AT. We determined whether whole blood impedance aggregometry using the Multiplate® (Dynabyte and IL France) detects the effects of AT as reliably as does classical light transmission aggregometry (LTA) (PAP-8, Biodis). We compared also results with those obtained on PFA-100TM (Siemens). Patients and Methods Ninety-three controls, healthy volunteers or patients wit

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Ponschab, Martin, Martijn van Griensven, Stefan Heitmeier, et al. "Platelet function in baboons and humans — A comparative study of whole blood using impedance platelet aggregometry (Multiplate®)." Thrombosis Research 147 (November 2016): 115–21. http://dx.doi.org/10.1016/j.thromres.2016.10.005.

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Halimeh, S., G. de Angelis, A. Sander, et al. "Multiplate®Whole Blood Impedance Point of Care Aggregometry: Preliminary Reference Values in Healthy Infants, Children and Adolescents." Klinische Pädiatrie 222, no. 03 (2010): 158–63. http://dx.doi.org/10.1055/s-0030-1249081.

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Marschner, Clara B., Annemarie T. Kristensen, Eva H. Spodsberg, and Bo Wiinberg. "Evaluation of platelet aggregometry in dogs using the Multiplate platelet analyzer: impact of anticoagulant choice and assay duration." Journal of Veterinary Emergency and Critical Care 22, no. 1 (2012): 107–15. http://dx.doi.org/10.1111/j.1476-4431.2011.00709.x.

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Petricevic, M., S. Konosic, B. Biocina, et al. "Bleeding risk assessment in patients undergoing elective cardiac surgery using ROTEM®platelet and Multiplate®impedance aggregometry." Anaesthesia 71, no. 6 (2016): 636–47. http://dx.doi.org/10.1111/anae.13303.

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Li, JiaXin, Moo Hyun Kim, LongZhe Guo, et al. "Impact of CYP2C19 Polymorphism on Antiplatelet Potency of Prasugrel 5 and 10 mg Daily Maintenance." Cardiology 140, no. 3 (2018): 155–62. http://dx.doi.org/10.1159/000491598.

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Background: Whether genetic polymorphisms (GP) impact residual platelet aggregation (RPA) following prasugrel is unclear, especially during maintenance phase. We assessed the influence of CYP2C19 GP carriers on RPA in the prospective observational cohort study. Methods and Results: All post-stent patients (n = 206) received prasugrel 60 mg loading and either 5 or 10 mg daily maintenance with aspirin100 mg. RPA levels by light transmission aggregometry (LTA), multiplate electrode aggregometry (MEA), and VerifyNow (P2Y12 reaction units, PRU) with CYP2C19 GP were measured simultaneously. Demograp

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