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Dissertations / Theses on the topic 'Multiple antibiotic resistance index'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Whiteley, Rosalind. "Effect of multiple antibiotic treatments on the evolution of antibiotic resistance in Pseudomonas aeruginosa." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:ee7c9dd7-bdcf-481b-b16c-9bb7b99f5328.

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To combat the ever-growing clinical burden imposed by antibiotic-resistant pathogens, multiple-antibiotic treatments are increasingly being considered as promising treatment options. The impact of multiple-antibiotic treatments on the evolution of resistance is not well understood however, and debate is ongoing about the effectiveness of various multiple-antibiotic treatments. In this thesis, I investigate how aspects of multiple-antibiotic treatments impact the rate of evolution of antibiotic resistance in the opportunistic human pathogen Pseudomonas aeruginosa. In particular, I look at the i

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2

Randall, Luke Patrick. "The multiple antibiotic resistance locus in salmonella from animals." Thesis, Royal Holloway, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393687.

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In order to understand the role of the Multiple Antibiotic Resistance (mar) locus in the Biology of Salmonella, a Typhimurium DT104 marA:: g fp:: cam reporter mutant was constructed. Expression of mar in Salmonella, as observed for E. coli, did induce low level multiple antibiotic resistance and cyclohexane resistance. However, mar expression in Salmonella did not appear to down regulate OmpF as has been observed for E. coli. Both in-vitro and in-vivo tests suggested that mar contributed to the virulence of Salmonella. The exact mechanism whereby mar contributes to virulence is uncertain. It c

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3

Suarez, Rachel. "Chemical disinfectant resistance in multiple antibiotic resistant and susceptible bacteria." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ57585.pdf.

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4

Ozaktas, Tugba. "Multiple Antibiotic Resistance Of Surface Mucus Dwelling Bacterial Populations In Freshwater Fish." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12609113/index.pdf.

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Surface mucus of a freshwater fish, Alburnus alburnus (bleak), caught from Lake Mogan, situated in south of Ankara, was collected in different seasons. The total cultivable bacteria were enumerated by spread plate method on nine different media. Bacteria were isolated based on colony morphologies and pigmentation. A total of sixty bacterial isolates obtained. The mucus-dwelling bacteria were first tested for resistance against ampicillin and kanamycin<br>then streptomycin and chloramphenicol were added to the experimental set up. The resistance levels of isolates were determined in terms of fo

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5

O'Connell, Heather Adele. "The Role of Ecological Interactions in Polymicrobial Biofilms and their Contribution to Multiple Antibiotic Resistance." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/13.

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The primary objectives of this research were to demonstrate that: 1.) antibiotic resistant bacteria can promote the survival of antibiotic sensitive organisms when grown simultaneously as biofilms in antibiotics, 2.) community-level multiple antibiotic resistance of polymicrobial consortia can lead to biofilm formation despite the presence of multiple antibiotics, and 3.) biofilms may benefit plasmid retention and heterologous protein production in the absence of selective pressure. Quantitative analyses of confocal data showed that ampicillin resistant organisms supported populations of ampic

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6

Oprica, Cristina. "Characterisation of antibiotic-resistant Propionibacterium acnes from acne vulgaris and other diseases /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-755-3/.

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7

Arntjen, Birte [Verfasser]. "Der Einfluss von multiple antibiotic resistance (mar) Mutationen auf die Fitness fluorchinolonresistenter Mutanten von Escherichia coli / Birte Arntjen." Aachen : Shaker, 2011. http://d-nb.info/1071529293/34.

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8

Hakizimana, Pierre. "Phosphatidylethanolamine regulates the function and the structure of LmrP, a bacterial multidrug transporter protein associated to antibiotic resistance." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210486.

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The multidrug transporter LmrP, member of the major facilitator superfamily (MFS), confers L. lactis and recombinant E. coli cells resistance to an array of cytotoxic compounds including antibiotics. LmrP mediates drug extrusion from the plasma membrane by an electrogenic proton/drug exchange reaction, whereby a positively charged substrate may move towards the external medium in exchange for two or more protons moving towards the cytoplasm. Recent studies have suggested that MFS transporters require phosphatidylethanolamine (PE) for function and proper topology. However, the specificity of th

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9

Khan, Ghazanfar Ali. "Monitoring anti-infectives and antibiotic resistance genes : with focus on analytical method development, effects of antibiotics and national perspectives." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61682.

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Antibiotics are biologically active and are globally used in humans and animal medicine for treatment and in sub-therapeutic amounts as growth promoters in animal husbandry, aquaculture and agriculture. After excretion, inappropriate disposal and discharge from drug production facilities they enter into water bodies either as intact drugs, metabolites or transformed products. In water environments they promote development of antibiotic resistance genes (ARGs) which could serve as a reservoir and be horizontally transferred to human-associated bacteria and thus contribute to AR proliferation. M

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10

Hernández, Jessica. "Design et synthèse de nouveaux inhibiteurs de la résistance bactérienne ciblant la pompe d'efflux AcrAB-ToIC chez Enterobacter aerogenes." Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5508.

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La surexpression des pompes d’efflux (PE) appartenant à la famille Resistance-Nodulation-Division (RND) est l’un des contributeurs majeurs de la multirésistance (MDR) et la pathogénicité des bactéries Gram-négatives. Ces transporteurs sont capables d'expulser à l’extérieur de la cellule bactérienne différentes classes d'antibiotiques, ce qui contribue de manière significative à l'échec thérapeutique du traitement des maladies infectieuses. Dans ce contexte, les PEs sont des cibles intéressantes pour la découverte de nouveaux antimicrobiens. Afin de combattre ce mécanisme de résistance, des inh

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11

Hernández, Jessica. "Design et synthèse de nouveaux inhibiteurs de la résistance bactérienne ciblant la pompe d'efflux AcrAB-ToIC chez Enterobacter aerogenes." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5508.

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La surexpression des pompes d’efflux (PE) appartenant à la famille Resistance-Nodulation-Division (RND) est l’un des contributeurs majeurs de la multirésistance (MDR) et la pathogénicité des bactéries Gram-négatives. Ces transporteurs sont capables d'expulser à l’extérieur de la cellule bactérienne différentes classes d'antibiotiques, ce qui contribue de manière significative à l'échec thérapeutique du traitement des maladies infectieuses. Dans ce contexte, les PEs sont des cibles intéressantes pour la découverte de nouveaux antimicrobiens. Afin de combattre ce mécanisme de résistance, des inh

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12

Sherley, Miranda. "The evolution and maintenance of multiple-antibiotic-resistance-plasmids in the enterobacteriaceae." Phd thesis, 2002. http://hdl.handle.net/1885/148554.

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13

Hayes, Joshua Richard. "Multiple antibiotic resistances of Enterococci from the poultry production environment and characterization of the macrolide-lincosamide-streptogramin resistance phenotypes of Enterococcus faecium." 2004. http://hdl.handle.net/1903/249.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2004.<br>Thesis research directed by: Cell Biology & Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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14

Ramatlhape, Lerato Lisbeth Njaki. "The assessment of multiple antibiotic resistant enterococci in communal and commercial cattle faecal samples and their water sources in Mafikeng, North-West Province, RSA / Lerato Lisbeth Njaki Ramatlhape." Thesis, 2006. http://hdl.handle.net/10394/11221.

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Enterococcus species are found in faeces of mammals, birds, insects, reptiles, but also soil, plants and water. These bacteria can also be isolated from animal products such as milk, cheese and meat. This study was aimed at isolating Enterococcus species from communal and commercial cattle faecal and water samples. A further objective was to determine the antibiotic resistance profiles of the isolates as well as some of the potential factors and mechanisms that could be responsible for their resistance to antibiotics. A total of 79 cattle faecal and water samples were collected from the commun

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15

Mudau, Khuthadzo Lunsford. "An assessment of water quality and occurrence of antibiotic-resistant bacteria in Naauwpoortspruit River, Mpumalanga province, South Africa." Diss., 2021. http://hdl.handle.net/10500/27841.

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Decreasing surface water quality in South Africa has become an issue of concern as the population grows, industrial and agricultural activities expand, and environmental pollution increases. Wastewater treatment plants and other anthropogenic activities are liable for releasing raw and inadequately treated effluents into the surface water. Extensive pollution accompanied by the use of disinfectants, pesticides, and other chemical pollutants has been attributed to increased antimicrobial resistance in bacteria such as Escherichia coli in surface water, increasing environmental antibiotic resi

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