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Journal articles on the topic 'Multiple cases studies'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Woo, Douglas A., Robert H. Collins, Howard S. Rossman, Olaf Stüve, and Elliot M. Frohman. "Mitoxantrone-Associated Leukemia in Multiple Sclerosis: Case Studies." International Journal of MS Care 10, no. 2 (2008): 41–46. http://dx.doi.org/10.7224/1537-2073-10.2.41.

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This article describes four new cases from our clinical practices of therapy-related acute leukemia after use of mitoxantrone in the treatment of patients with multiple sclerosis (MS) and reviews the mechanisms that predispose to this serious complication of treatment. The study consisted of a retrospective case series. Four previously unreported cases of secondary leukemia arising after mitoxantrone therapy in MS patients were identified, out of a combined cohort of 152 patients treated at our institutions. Three of the patients developed the acute promyelocytic leukemia subtype, after varyin

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Oscar, Fernando Gutiérrez Rincón, Moreno García Santiago, José Hoyos Bedoya Maria, and Juliana Builes Cerón Sarah. "Multiple Cavernous Malformations: A Case Report." Journal of Clinical Cases & Reports 3, no. 1 (2020): 5–13. http://dx.doi.org/10.46619/joccr.2020.3-1053.

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Cavernous malformations are alterations in the conformation of arteries and veins that can be found both intracranial and intraspinal; however, the variables are very important for the diagnosis and treatment of patients. The main clinical manifestation is epileptic seizures in cases of bleeding, but in many cases they are asymptomatic in the course of life and are found as findings related to neuroimaging studies for other reasons. It is more common to find unique lesions, but in cases of multiple lesions it is likely to find an autosomal dominant hereditary factor, which makes the person mor

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C, Maria Caceres Toledo, Caceres Toledo O, Miranda Palacio G, Villegas Albarran G, and Osmin Tamargo Barbeito CT. "Neuro-Ophthalmological Evaluation in Patients with Multiple Sclerosis." Open Access Journal of Ophthalmology 10, no. 1 (2025): 1–5. https://doi.org/10.23880/oajo-16000332.

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Multiple Sclerosis (MS) is a chronic, autoimmune, inflammatory, demyelinating disease that affects the central nervous system. Objective. To evaluate the evolution of retinal and optic nerve ophthalmological manifestations in Multiple Sclerosis. Method. A prospective, descriptive, longitudinal study was carried out in a series of patients with MS, referred to the Neuroophthalmology clinic of the “Hermanos Ameijeiras” Hospital in the period from June 2021 to September 2022. Results. The average age was 43.1 years, with a predominance of the female sex (76.3%). The predominant clinical form was

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Bayar, Gürkan Raşit, Kerim Ortakoḡlu, and Metin Sencimen. "Multiple Impacted Teeth: Report of 3 Cases." European Journal of Dentistry 02, no. 01 (2008): 73–78. http://dx.doi.org/10.1055/s-0039-1697358.

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ABSTRACTWhile impaction of tooth is widespread, multiple impacted teeth by itself is a rare condition and often found in association with syndromes such as cleidocranial dysplasia or Gardner’s syndrome. A light of radiographic examination, we describe three Turkish young males with multiple impacted teeth who didn’t possess any systemic conditions or syndromes involving both jaws. The first patient, a 21-year-old young male, had 16 unerupted teeth and 5 unerupted supernumerary teeth. The second patient with totally edentulous mandible, a 20-year-old young male, had 31 unerupted teeth. The thir

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Li-Ching, Huang, Wen Miin-Jye, Cheung Siu Hung, and Kwong Koon Shing. "Noninferiority studies with multiple reference treatments." Statistical Methods in Medical Research 26, no. 3 (2015): 1295–307. http://dx.doi.org/10.1177/0962280215576017.

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The increasing popularity of noninferiority trials reflects the ongoing efforts to replace existing treatments (reference treatments) with new treatments (experimental treatments) that retain a substantial fraction of the effect of the reference treatments. The adoption of any new treatment has to be vindicated by a demonstration of benefits that outweigh a possible clinically insignificant reduction in the reference treatment efficacy. Statistical methods have been developed to analyze data collected from noninferiority trials. However, these methods focus on cases with only one reference tre

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Ana, Julia Dal Forno, Buss da Silva Priscila, Gabriel de Miranda Rodrigo, Cezar Bornia Antonio, and Antonio Forcellini Fernando. "Demand forecasting process evaluation: Multiple cases studies at 15 companies in Brazil." African Journal of Business Management 8, no. 12 (2014): 460–73. http://dx.doi.org/10.5897/ajbm2013.7185.

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STRICKLAND, LLOYD. "God's problem of multiple choice." Religious Studies 42, no. 2 (2006): 141–57. http://dx.doi.org/10.1017/s0034412506008249.

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A question that has been largely overlooked by philosophers of religion is how God would be able to effect a rational choice between two worlds of unsurpassable goodness. To answer this question, I draw a parallel with the paradigm cases of indifferent choice, including Buridan's ass, and argue that such cases can be satisfactorily resolved provided that the protagonists employ what Otto Neurath calls an ‘auxiliary motive’. I supply rational grounds for the employment of such a motive, and then argue against the views of Leibniz and Nicholas Rescher to show that this solution would also work f

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Boyko, Alexey, and Mikhail Melnikov. "Prevalence and Incidence of Multiple Sclerosis in Russian Federation: 30 Years of Studies." Brain Sciences 10, no. 5 (2020): 305. http://dx.doi.org/10.3390/brainsci10050305.

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In the Russian Federation, multiple sclerosis prevalence rates vary from 10 to 80 cases per 100,000, depending on region and the nationality of the population. The main characteristics of multiple sclerosis epidemiology in the XX century in this big territory are: (1) steady increase in multiple sclerosis prevalence and incidence rates, maybe because of better diagnosis and treatment, but also changes in environmental/epigenetic risk profile and/or lifestyle factors; (2) increase of the female to male ratio, increase in multiple sclerosis incidence mainly in females; (3) appearance and increas

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Cowley, R. Adams, and Alasdair K. T. Conn. "Prehospital and Intrahospital Specialized Management of Severe Multiple Trauma Cases." Prehospital and Disaster Medicine 1, S1 (1985): 149–50. http://dx.doi.org/10.1017/s1049023x00044228.

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Multiple trauma is the leading cause of death of all Americans below the age of 37. The estimated cost to American society is between 70 and 80 billion dollars per year. In our present day society, one person in four will require the use of a trauma facility during his or her lifetime. Several studies have now been performed to demonstrate that the management of trauma is woefully inadequate. Stemming from the classical studies of Trunkey, Lim and West comparing San Francisco with Orange County, California; it was demonstrated that approximately 30% of fatalities resulting from traumatic injur

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Baratova, D., and M. Baratova. "ANEMIA AND MULTIPLE MYELOMA DIAGNOSIS, TREATMENT." Scientific heritage, no. 158 (April 7, 2025): 23–31. https://doi.org/10.5281/zenodo.15170203.

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The article presents the results of studies of primary patients when contacting a hematologist on the indicators of hemoglobin (Hb) levels in the blood, a high, persistent level of erythrocyte sedimentation rate (ESR), which make it possible to suspect about pre-tumor conditions and the course of multiple myeloma (MM) with the help of additional clinical and laboratory studies, differential diagnostics. The disease with multiple myeloma among the kirghiz population is less common compared to the Russian-speaking population residents of the Kyrgyz Republic (Kirghizia). When comparing the result

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Mescheriakova, Julia Y., Linda Broer, Simin Wahedi, André G. Uitterlinden, Cornelia M. van Duijn, and Rogier Q. Hintzen. "Burden of genetic risk variants in multiple sclerosis families in the Netherlands." Multiple Sclerosis Journal - Experimental, Translational and Clinical 2 (January 1, 2016): 205521731664872. http://dx.doi.org/10.1177/2055217316648721.

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Background Approximately 20% of multiple sclerosis patients have a family history of multiple sclerosis. Studies of multiple sclerosis aggregation in families are inconclusive. Objective To investigate the genetic burden based on currently discovered genetic variants for multiple sclerosis risk in patients from Dutch multiple sclerosis multiplex families versus sporadic multiple sclerosis cases, and to study its influence on clinical phenotype and disease prediction. Methods Our study population consisted of 283 sporadic multiple sclerosis cases, 169 probands from multiplex families and 2028 c

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Fatoki, Raleigh Ayoolu, Diane M. Carpenter, Nirmala D. Ramalingam, et al. "Smoldering multiple myeloma progression to multiple myeloma in a community-based population." Journal of Clinical Oncology 40, no. 16_suppl (2022): e20015-e20015. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e20015.

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e20015 Background: Few studies have characterized patients with smoldering multiple myeloma (SMM) in ethnically diverse settings and data regarding progression to multiple myeloma (MM) in real-world clinical populations is limited. Using data from a large healthcare system, we examined a contemporary cohort of adults with confirmed SMM and their progression to MM. Methods: We conducted a retrospective cohort study of SMM cases from 2010-2017 in Kaiser Permanente Northern California (KPNC). We used the KPNC SEER-based Cancer Registry to identify potential SMM cases by ascertaining MM cases with

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Oh, Patricia A. "DEVELOPING AGE-FRIENDLY COMMUNITIES: EVIDENCE FROM MULTIPLE CASE STUDIES." Innovation in Aging 3, Supplement_1 (2019): S183. http://dx.doi.org/10.1093/geroni/igz038.654.

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Abstract The age-friendly community movement is gaining momentum in the United States. More than 325 communities have joined the AARP Network of Age-Friendly States and Communities or the WHO Global Network of Age-Friendly States and Communities. The purpose of this multiple case study was to explore what influences municipal decision-making about joining a network and how communities mobilize the resources at their disposal to make age-friendly changes after joining. The conceptual model that guided this exploratory study incorporated Kingdon’s policy change model to explore municipal decisio

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Onegin, Е. V., M. D. Semashko, and V. P. Vdovichenko. "FEATURES OF PEDIATRIC MULTIPLE SCLEROSIS." Journal of the Grodno State Medical University 19, no. 3 (2021): 270–73. http://dx.doi.org/10.25298/2221-8785-2021-19-3-270-273.

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Background. Demyelinating diseases are one of the most pressing and debatable problems in neurology. Despite the emergence of improved diagnostic criteria and new directions in therapy, multiple sclerosis is a leading cause of disability among young patients. According to epidemiological studies, about 3 million people worldwide suffer from multiple sclerosis. At the same time, from 2.7 to 10.5% of all cases of multiple sclerosis worldwide are observed in children under the age of 18, with a tendency towards an increase in the disease incidence. Purpose. To analyze the results of scientific st

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Sun, Jie Li, Yun Lu, and Fu Liang Li. "Research on Multiple Cases Database Construction of Case-Based Reasoning Personalized Recommendation System." Applied Mechanics and Materials 303-306 (February 2013): 1448–51. http://dx.doi.org/10.4028/www.scientific.net/amm.303-306.1448.

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The multiple cases database construction is one of the important links to design the personalized recommendation system. Personalized recommendation system case can be organized with multiple cases database based on expert experience and thinking patterns, combined with the traditional case method of organization. This paper studies the multiple cases database construction method of the personalized recommendation system based-CBR.

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O’Campo, Patricia, Alix Freiler, Carles Muntaner, et al. "Resisting austerity measures to social policies: multiple explanatory case studies." Health Promotion International 34, no. 6 (2018): 1130–40. http://dx.doi.org/10.1093/heapro/day073.

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Abstract Since Margaret Thatcher reached power in the United Kingdom, European governments have increasingly turned to neoliberal forms of policy-making, focusing, especially after the 2008 Great Recession on ‘austerity policies’ rather than investing in social protection policies. We applied a multiple explanatory case studies methodology to examine how and why challenges and resistance to these austerity measures are successful or not in four settings for three different social policy issues: using a gender lens in state budgeting in Andalusia (Spain), maintaining unemployment benefits in It

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Tsonaka, R., M. C. H. De Visser, and J. Houwing-Duistermaat. "Estimation of genetic effects in multiple cases family studies using penalized maximum likelihood methodology." Biostatistics 14, no. 2 (2012): 220–31. http://dx.doi.org/10.1093/biostatistics/kxs032.

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Fellman, Johan. "Studies of the Seasonal Pattern of Multiple Maternities." Twin Research and Human Genetics 20, no. 3 (2017): 250–56. http://dx.doi.org/10.1017/thg.2017.20.

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The seasonality of population data has been of great interest in demographic studies. When seasonality is analyzed, the population at risk plays a central role. In a study of the monthly number of births and deaths, the population at risk is the product of the size of the population and the length of the month. Usually, the population can be assumed to be constant, and consequently, the population at risk is proportional to the length of the month. Hence, the number of cases per day has to be analyzed. If one studies the seasonal variation in twin or multiple maternities, the population at ris

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Cristiano, E., JI Rojas, M. Romano, et al. "The epidemiology of multiple sclerosis in Latin America and the Caribbean: a systematic review." Multiple Sclerosis Journal 19, no. 7 (2012): 844–54. http://dx.doi.org/10.1177/1352458512462918.

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The incidence and prevalence of multiple sclerosis (MS) varies geographically as shown through extensive epidemiological studies performed mainly in developed countries. Nonetheless, scant data is available in Latin America and the Caribbean (LAC). The objective of this review is to assess epidemiological data of MS in LAC. We conducted a systematic review of published articles and gray literature from January 1995 to May 2011. Twenty-two studies met the inclusion criteria after full-text review. Incidence data were found in only three studies and ranged from 0.3 to 1.9 annual cases per 100,00

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Cristiano, Edgardo, and Juan Ignacio Rojas. "Multiple sclerosis epidemiology in Latin America: An updated survey." Multiple Sclerosis Journal - Experimental, Translational and Clinical 3, no. 2 (2017): 205521731771505. http://dx.doi.org/10.1177/2055217317715050.

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Novel epidemiological data have appeared in recent years in Latin America (LATAM). The objective of this study was to perform an updated systematic review of the epidemiology of the disease reported in LATAM. Methods We conducted a systematic review of published epidemiological articles from January 1995 to December 2016. Results Incidence data were found in four studies and ranged from 0.3 to 3 annual cases per 100,000 person-years. Prevalence was reported in 13 studies and ranged from 0.83 to 38.2 cases per 100,000 inhabitants. Two studies showed an increase in prevalence and incidence in th

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Cabrera-Gómez, JA, L. Ramón-Pérez, A. Saiz, et al. "Neuromyelitis optica and multiple sclerosis in sisters." Multiple Sclerosis Journal 15, no. 2 (2008): 269–71. http://dx.doi.org/10.1177/1352458508097921.

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Introduction The association of neuromyelitis optica (NMO) and multiple sclerosis (MS) has been reported, but details of the cases were not described. We report two Venezuelan Caucasian sisters with human leukocyte antigen (HLA) typing. Results Patient 1 fulfilled McDonald, et al. criteria with HLA A*24; B*07,*15; DRB1*01,*16 (DR2 positive). Patient 2 fulfilled the NMO revised criteria of Wingerchuck, et al. with HLA A*02,*24; B*07,*40; DRB1*04,*08, similar to Canadian aboriginal NMO cases and the Yukpa population from Venezuela. Conclusion These cases confirmed the coexistence of NMO and MS i

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Meira-Machado, Luís, Carla Moreira, Gustavo Soutinho, and Marta Azevedo. "Analysis of Survival Data with Multiple Events." WSEAS TRANSACTIONS ON MATHEMATICS 21 (December 31, 2022): 854–63. http://dx.doi.org/10.37394/23206.2022.21.97.

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An important aim in biomedical studies is to study how an intermediate event and prognostic factors influence the course of disease of a patient. In most cases, the effect of the intermediate event is considered a timedependent covariate and studied using extensions of the Cox proportional hazards model. Additionally, many of these studies often involve several endpoints, making the traditional approaches much more complicated. In such cases, multi-state models provide a useful tool to describe the survival process. This article aims to illustrate how multi-state models can be used as an alter

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Baratova, D., and M. Baratova. "MULTIPLE MYELOMA AND HELICOBACTER PYLORI INFECTION DIAGNOSIS, TREATMENT AND PREVENTION." Scientific heritage, no. 132 (March 8, 2024): 26–30. https://doi.org/10.5281/zenodo.10795944.

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The article presents the results of studies using an invasive diagnostic method to determine the levels of IgG antibodies to Helicobacter pylori (H.pylori) infection in patients with multiple myeloma of kirghiz nationality in comparison with patients with multiple myeloma of the Russian-speaking population residents of the Kyrgyz Republic(Kirghizia). At the comparative characteristic in patients with multiple myeloma of kirghiz nationality reveal negative in 49 % of cases, medium levels in 21%  cases, high levels in 18% of cases and less often low levels of IgG antibodies to H.pylori infe

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Page, Damien. "The multiple impacts of teacher misbehaviour." Journal of Educational Administration 54, no. 1 (2016): 2–18. http://dx.doi.org/10.1108/jea-09-2014-0106.

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Purpose – The purpose of this paper is to investigate the impacts of serious teacher misbehaviour (TMB) in schools from the perspective of headteachers, a largely un-researched area. Design/methodology/approach – Data were collected via the documentary analysis of misconduct cases from the Teaching Agency and semi-structured interviews with five headteachers who had managed serious cases. Findings – The research suggests four primary impacts of serious TMB, affecting other teachers, students, the reputation of the school and headteachers themselves. The paper concludes by suggesting a fifth im

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Plotogea, Mihaela, Claudia Mehedintu, Valentin Nicolae Varlas, et al. "Pregnancy in the context of Multiple Sclerosis." Romanian Medical Journal 69, no. 3 (2022): 100–104. http://dx.doi.org/10.37897/rmj.2022.3.2.

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Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder which affects brain, spinal cord and optic nerve. During last years the perception over the disease changed dramatically, now being considered a handleable disease. The particularity of this subject is that Multiple Sclerosis is a disease which affects mostly young women, many of them not having any children at the moment of diagnosis. This article highlights the fact that women diagnosed with Multiple Sclerosis are allowed to get pregnant, and, moreover, they are encouraged to live a normal life. In most cases, disease acti

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Lee, Ju Hie, So Yeon Yu, Mun Ho Yang, Lin Chang, and Young Tae Ko. "Multiple lymphomatous polyposis of the gastrointestinal tract: a report of two cases with immunohistochemical studies." Journal of Korean Medical Science 7, no. 2 (1992): 173. http://dx.doi.org/10.3346/jkms.1992.7.2.173.

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Adam, Kindi, Krisna Nur Andriana Pangesti, and Vivi Setiawaty. "Multiple Viral Infection Detected from Influenza-Like Illness Cases in Indonesia." BioMed Research International 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/9541619.

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Influenza is one of the common etiologies of the upper respiratory tract infection (URTI). However, influenza virus only contributes about 20 percent of influenza-like illness patients. The aim of the study is to investigate the other viral etiologies from ILI cases in Indonesia. Of the 334 samples, 266 samples (78%) were positive at least for one virus, including 107 (42%) cases of multiple infections. Influenza virus is the most detected virus. The most frequent combination of viruses identified was adenovirus and human rhinovirus. This recent study demonstrated high detection rate of severa

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Koch-Henriksen, Nils. "The Danish Multiple Sclerosis Registry: a 50-year follow-up." Multiple Sclerosis Journal 5, no. 4 (1999): 293–96. http://dx.doi.org/10.1177/135245859900500418.

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The Danish Multiple Sclerosis Registry was established in 1948 in continuation with a nationwide survey of the prevalence of Multiple Sclerosis (MS) in Denmark. The register has since collected information on MS patients from all Danish departments of neurology, practising neurologists, MS rehabilitation centres, the National Patient Registry, the Danish MS Society, and departments of neuropathology. The registry is linked with the Danish Central Population Registry. The completeness has been estimated at more than 90%. All cases are reclassified by two neurologists as to diagnosis and year of

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Zaadstra, BM, AMJ Chorus, S. van Buuren, H. Kalsbeek, and JM van Noort. "Selective association of multiple sclerosis with infectious mononucleosis." Multiple Sclerosis Journal 14, no. 3 (2008): 307–13. http://dx.doi.org/10.1177/1352458507084265.

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Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population-based case-control study involving 2877 MS cases and 2673 controls in the Netherlands. We examined the frequency of different common infections and afflictions before the age of 25 and the age at which they occurred, using a self-administered questionn

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Казаков, С. П., Д. В. Решетняк, И. В. Клеина, and О. А. Рукавицын. "Using of Cytogenetic Studies for Diagnosis and Therapy of Multiple Myeloma." Гематология. Трансфузиология. Восточная Европа, no. 1 (March 24, 2023): 18–23. http://dx.doi.org/10.34883/pi.2023.9.1.005.

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В ходе работы по созданию оптимального диагностического алгоритма для выявления множественной миеломы (ММ) и мониторинга ее терапии нами была проведена оценка эффективности использования цитогенетических исследований при диагностике и терапии ММ. Был проведен анализ 115 случаев ММ по результатам цитогенетического и цитологического исследований. Выявлено, что генетические нарушения имели место в 82,6% случаев ММ, а количество плазмоцитов в миелограмме могло иметь тенденцию к увеличению в зависимости от повышения сформированной цитогенетическим исследованием группы риска. Использование цитогенет

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Larkosh, Christopher. "“Québex”: Post-Nations, Translations, and Other Cases of Multiple Identity." Contemporary French and Francophone Studies 13, no. 1 (2009): 55–65. http://dx.doi.org/10.1080/17409290802606820.

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Marrie, Ruth Ann, and Christina Wolfson. "Multiple Sclerosis and Epstein-Barr Virus." Canadian Journal of Infectious Diseases 13, no. 2 (2002): 111–18. http://dx.doi.org/10.1155/2002/745764.

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OBJECTIVE: To evaluate the epidemiological evidence for an etiological role of Epstein-Barr virus in multiple sclerosis (MS).DATA SOURCES: MEDLINE and Cochrane Library searches of the medical literature identified 24 studies.DATA EXTRACTION: Studies were categorized as seroepidemiological, case-control or historical cohort, and were then classified within each group according to methodological rigour using criteria derived from published guidelines for the epidemiological study of MS.DATA SYNTHESIS: There was significant variability in the quality of evidence, and while two well-designed cohor

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Colwill, Michael, Samantha Baillie, Richard Pollok, and Andrew Poullis. "Using clinical cases to guide healthcare." World Journal of Clinical Cases 12, no. 9 (2024): 1555–59. http://dx.doi.org/10.12998/wjcc.v12.i9.1555.

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Evidence-based practice (EBP) has been the gold standard in healthcare for nearly three centuries and aims to assist physicians in providing the safest and most effective healthcare for their patients. The well-established hierarchy of evidence lists systematic reviews and meta-analyses at the top however these methodologies are not always appropriate or possible and in these instances case-control studies, case series and case reports are utilised to support EBP. Case-control studies allow simultaneous study of multiple risk factors and can be performed rapidly and relatively cheaply. A recen

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YUMIBA, Takeyoshi, Hiroshi TAKANO, Hiroshi YOKOTA, et al. "CLINICAL STUDIES ON MULTIPLE PRIMARY CANCERS INCLUDING THE COLON AND RECTUM -A REPORT OF 62 CASES-." Journal of the Japanese Practical Surgeon Society 48, no. 3 (1987): 330–34. http://dx.doi.org/10.3919/ringe1963.48.330.

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Erickson, Robert P., J. F. Stone, Leslie A. McNoe, and Michael R. Eccles. "Molecular and clinical studies of three cases of female pseudohermaphroditism with caudal dysplasia suggest multiple etiologies." Clinical Genetics 51, no. 5 (2008): 331–37. http://dx.doi.org/10.1111/j.1399-0004.1997.tb02483.x.

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McCarthy, I. D., and S. P. Hughes. "Multiple tracer studies of bone uptake of 99mTc-MDP and 85Sr." American Journal of Physiology-Heart and Circulatory Physiology 256, no. 5 (1989): H1261—H1265. http://dx.doi.org/10.1152/ajpheart.1989.256.5.h1261.

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Multiple tracer outflow dilution studies were performed on the normal canine tibia. In all cases 125I-labeled albumin was used as a vascular tracer. In one series of experiments 99mTc-labeled methylene diphosphonate and [14C]sucrose were used as test tracers, and in a second series 85Sr and 22Na were used. A bolus of three tracers was injected into the tibial nutrient artery, and fractional concentrations appearing in the ipsilateral femoral vein were measured for a period of 5 min. A distributed model, containing parameters for capillary and bone permeability and apparent volumes of distribut

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Papantoniou, Kyriaki, Jennifer Massa, Elizabeth Devore, et al. "Rotating night shift work and risk of multiple sclerosis in the Nurses’ Health Studies." Occupational and Environmental Medicine 76, no. 10 (2019): 733–38. http://dx.doi.org/10.1136/oemed-2019-106016.

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ObjectivesNight shift work has been suggested as a possible risk factor for multiple sclerosis (MS). The objective of the present analysis was to prospectively evaluate the association of rotating night shift work history and MS risk in two female cohorts, the Nurses’ Health Study (NHS) and NHSII.MethodsA total of 83 992 (NHS) and 114 427 (NHSII) women were included in this analysis. We documented 579 (109 in NHS and 470 in NHSII) incident physician-confirmed MS cases (moderate and definite diagnosis), including 407 definite MS cases. The history (cumulative years) of rotating night shifts (≥3

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Reiter-Campeau, S., and D. Gendron. "P.101 A-waves on electrodiagnostic studies in axonal and demyelinating cases of Guillain-Barré Syndrome (GBS)." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 49, s1 (2022): S35. http://dx.doi.org/10.1017/cjn.2022.196.

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Background: A-waves are lesser-known late responses of debated clinical significance, seen in routine motor nerve conduction studies (NCS). They are proposed to be a sensitive marker of demyelination and an early finding in acute demyelinating polyradiculoneuropathy (AIDP). We hypothesized that the presence and distribution of A-waves are discriminative markers in differentiating AIDP from axonal variants of Guillain-Barré Syndrome (GBS). Methods: We identified patients diagnosed with demyelinating and axonal forms of GBS at the Montreal Neurological Institute between 2016 and 2021. Clinical a

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Zhukovsky, C., M. A. Bind, I. Boström, and A. M. Landtblom. "Air pollution as a contributing factor of relapses and cases of multiplesclerosis." Health Risk Analysis, no. 3 (September 2020): 169–75. http://dx.doi.org/10.21668/health.risk/2020.3.20.

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The role of air pollution exposure in multiple sclerosis (MS) incidence and relapse worldwide has not yielded a consensus; some studies have reported positive associations, which have failed to reject the null hypothesis. Potential reasons for these contradictory results can in part be explained by differences in study designs and their associated limitations. Of note, rat and canine studies in 2010 and 2013, respectively, have shown that expression of HO-1 enzyme and inflammatory factors increased due to PM10 and diesel engine exhaust (DEE) exposure. Of the eight non-null epidemiological stud

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Zhukovsky, C., M. A. Bind, I. Boström, and A. M. Landtblom. "Air pollution as a contributing factor of relapses and cases of multiplesclerosis." Health Risk Analysis, no. 3 (September 2020): 169–75. http://dx.doi.org/10.21668/health.risk/2020.3.20.eng.

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The role of air pollution exposure in multiple sclerosis (MS) incidence and relapse worldwide has not yielded a consensus; some studies have reported positive associations, which have failed to reject the null hypothesis. Potential reasons for these contradictory results can in part be explained by differences in study designs and their associated limitations. Of note, rat and canine studies in 2010 and 2013, respectively, have shown that expression of HO-1 enzyme and inflammatory factors increased due to PM10 and diesel engine exhaust (DEE) exposure. Of the eight non-null epidemiological stud

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Correia, Ana Sofia, Luís Augusto, Joana Meireles, Joana Pinto, and Ana Paula Sousa. "Pediatric Multiple Sclerosis in Portugal: A Multicentre Study." Acta Médica Portuguesa 29, no. 7-8 (2016): 425. http://dx.doi.org/10.20344/amp.6346.

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Introduction: Multiple sclerosis is most often diagnosed among young adults but less frequently it may present during childhood or adolescence. In Portugal, there has been only one previous single-center, pediatric multiple sclerosis study. The main objective was the evaluation of the demographic, clinical, laboratorial and neuroradiological characteristics of patients with pediatric-onset multiple sclerosis in Portugal. The secondary objectives were to compare the characteristics of childhood-onset multiple sclerosis and adolescent-onset multiple sclerosis and to characterize the treatments p

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Patel, Kevin R., Amel Karaa, and Farrah J. Mateen. "Relapsing remitting multiple sclerosis in progressive external ophthalmoplegia: A report of two cases." Multiple Sclerosis Journal 25, no. 6 (2018): 879–82. http://dx.doi.org/10.1177/1352458518800794.

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Evidence from genetic and pathologic studies suggests that mitochondrial dysfunction occurs in multiple sclerosis (MS). Furthermore, cases of MS have been reported in patients with mitochondrial disease. The phenotypic range of mitochondrial illness associating with MS is not yet well defined. In this report, we highlight two cases of patients with confirmed genetic mutations responsible for progressive external ophthalmoplegia who independently meet McDonald criteria for MS. Better characterization of the range of mitochondrial disease associated with MS may improve our understanding of MS di

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Lazo Chavez, K. L. "On purpose of multiple cases: Quaternary prevention on mental health – “Primum non-nocere”." European Psychiatry 41, S1 (2017): S581. http://dx.doi.org/10.1016/j.eurpsy.2017.01.874.

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IntroductionQuaternary prevention, concept coined by the Belgian Marc Jamoulle, are the actions taken to avoid or mitigate the consequences of unnecessary or excessive intervention of the health system. The concept alludes to actions to avoid the over-diagnoses and over-treatment, trying to reduce the incidence of iatrogeny in patients, which is a serious public health problem and even more in mental health.MethodsSystematic review of bibliography.ObjectivesDo a systematic review of bibliography and through the results invite to the analytic and critic reflection of our professional activities

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Dayan, Colin M., Beatriz Lecumberri, Ilaria Muller, et al. "Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies." Multiple Sclerosis Journal - Experimental, Translational and Clinical 9, no. 1 (2023): 205521732211427. http://dx.doi.org/10.1177/20552173221142741.

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Background Alemtuzumab is an effective therapy for relapsing multiple sclerosis. Autoimmune thyroid events are a common adverse event. Objective Describe endocrine and multiple sclerosis outcomes over 6 years for alemtuzumab-treated relapsing multiple sclerosis patients in the phase 3 CARE-MS I, II, and extension studies who experienced adverse thyroid events. Methods Endocrine and multiple sclerosis outcomes were evaluated over 6 years. Thyroid event cases, excluding those pre-existing or occurring after Year 6, were adjudicated retrospectively by expert endocrinologists independently of the

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Summers, Gordon W. "Parathyroid Update: A Review of 220 Cases." Ear, Nose & Throat Journal 75, no. 7 (1996): 434–39. http://dx.doi.org/10.1177/014556139607500713.

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A total of 220 patients have undergone cervical exploration for hyperparathyroidism by the author. A review of 125 cases was published in 1991. An additional 95 patients have been explored in the subsequent four years. Subtotal parathyroidectomy was performed in 39 patients with chronic renal failure. Exploration was successful in over 97% of the 181 patients diagnosed with primary hyperparathyroidism. Single adenomas were found in 146, double adenomas in 11, and multiple gland hyperplasia in 19 patients. Two of the five patients in whom cervical exploration failed were ultimately diagnosed wi

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Xie, Caide, Tianjing Zhao, and Liang Fang. "High-Resolution CT Findings of Leukemia Pulmonary Infiltration and Chemotherapy Outcome and In Vitro Study of Human Lung Tissue." Journal of Medical Imaging and Health Informatics 11, no. 2 (2021): 360–69. http://dx.doi.org/10.1166/jmihi.2021.3276.

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In order to explore the high-resolution CT findings of leukemia pulmonary infiltration and chemotherapy outcomes and the in vitro study of human lung tissue, this paper selected a total of 120 clinically or surgically confirmed leukemia patients at the designated hospital of the study from December 2014 to December 2018, and divided them into three groups according to the random number table method: pulmonary infiltration group, chemotherapy outcome group and in vitro study group, with 40 cases in each group. The CT imaging features of the three groups of patients were observed and summarized

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Joe, Jaewan, Piljae Im, and Jin Dong. "Empirical Modeling of Direct Expansion (DX) Cooling System for Multiple Research Use Cases." Sustainability 12, no. 20 (2020): 8738. http://dx.doi.org/10.3390/su12208738.

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This study provides a general procedure to generate a direct expansion (DX) cooling coil system for a roof top unit (RTU), which is a typical heating ventilation and air-conditioning (HVAC) system for commercial buildings in the United States. Experimental data from a full-scale unoccupied 2-story commercial building is used for the HVAC modeling. The regression for identifying the model coefficients was carried out with multiple stages, and the results were validated with measured data. The model’s applicability was evaluated with multiple case studies, including a building energy simulation

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Palta, Anshu, Manveen Kaur, Anita Tahlan, and Kislay Dimri. "Evaluation of Angiogenesis in Multiple Myeloma by VEGF Immunoexpression and Microvessel Density." Journal of Laboratory Physicians 12, no. 01 (2020): 38–43. http://dx.doi.org/10.1055/s-0040-1714933.

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Abstract Background Multiple myeloma (MM) is a plasma cell disorder characterized by monoclonal proliferation of plasma cells in bone marrow. Plasmablastic MM is a morphologic subset of MM, containing ≥2% plasmablasts of all plasma cells. Methods The study included 30 consecutively diagnosed patients of MM (6 plasmablastic, 24 nonplasmablastic) over a span of 2 years. Angiogenesis in MM was assessed by analysis of vascular endothelial growth factor (VEGF) immunoexpression by plasma cells and microvessel density (MVD) using anti-CD34 antibody. CD34 and VEGF immunohistochemical staining was perf

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Abhinanda, Sutradhar, and Toshi Mandloi Prof. "Optimal Power Flow with Facts: TCSCs and Case Studies." Advancement of Signal Processing and its Applications 4, no. 3 (2021): 1–8. https://doi.org/10.5281/zenodo.5748647.

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<em>Optimal power flow with multiple and multi-type FACTS devices has been performed to minimize generation cost and /or total transmission losses. The proposed model for OPF with FACTS devices has been validated with different test cases such as IEEE 30-bus system. The solutions of OPF with different and multi-type FACTS gadgets have been introduced exhaustively for IEEE 30- bus system </em>

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Gonçalves, Sidalina, José Biléu Ventura, Orlando Lima Rua, Rui Dias, and Rosa Galvão. "Relating Big Data, Value Creation, Performance and Decision-Making: Multiple Case Studies." Journal of Ecohumanism 3, no. 6 (2024): 1988–2017. http://dx.doi.org/10.62754/joe.v3i6.4155.

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This study aimed to understand how big data (BD) contributes to value creation in organisations and provides relevant, integrated, and timely information for the performance measurement/assessment model that supports top-management decision-making. The empirical study employs a qualitative methodology comprising five cases using the multiple-case study method. The data collection instrument was semi-structured interviews, and the MAXQDA software was used to treat and analyse the contents. The results show that BD creates value for organisations with positive effects on performance, namely on r

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