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Relevant bibliographies by topics / Multiple-Domain Matrix (MDM)

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Academic literature on the topic 'Multiple-Domain Matrix (MDM)'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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Journal articles on the topic "Multiple-Domain Matrix (MDM)"

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Juranić, J., N. Pavković, and D. Jurinić. "MANAGEMENT OF DESIGN ITERATIONS ON COUPLED PARAMETERS IN DESIGN TEAMWORK USING MULTIPLE DOMAIN MATRIX AND COLOURED PETRI NETS." Proceedings of the Design Society: DESIGN Conference 1 (May 2020): 617–26. http://dx.doi.org/10.1017/dsd.2020.264.

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AbstractA new way of structuring and interpretation of multiple domain matrix is proposed as the basis for categorisation of design parameter relations complexity. Depending on the kind and the degree of coupling of the parameters, the developed methodology activates the appropriate coloured Petri net (CPN) models for semi-automatic support of communication between the members of the design team. The proposed extension of MDM combined with CPN is a novel approach to predicting and managing communication patterns necessary during teamwork coordination on critical interfaces between product comp

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Shen, Yifan, Jianyong Zhang, Shuchao Mi, Guofang Fan, and Muguang Wang. "Efficient Frequency-Domain Block Equalization for Mode-Division Multiplexing Systems." Photonics 12, no. 2 (2025): 161. https://doi.org/10.3390/photonics12020161.

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In this paper, an adaptive frequency-domain block equalizer (FDBE) implementing the adaptive moment estimation (Adam) algorithm is proposed for mode-division multiplexing (MDM) optical fiber communication systems. By packing all frequency components into frequency-dependent blocks of a specified size B, we define an adaptive equalization matrix to simultaneously compensate for multiple frequency components at each block, which is computed iteratively using the Adam, recursive least squares (RLS) and least mean squares (LMS) algorithms. Simulations show that the proposed FDBE using the Adam alg

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Hou, Li, Jing Yang, Yanrong Li, et al. "Exploring the mechanism of action of Lobetyolin in the treatment of allergic rhinitis based on network pharmacology and molecular docking." Medicine 104, no. 7 (2025): e41496. https://doi.org/10.1097/md.0000000000041496.

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Lobetyolin (LBT) is an important active ingredient in the traditional medicinal plant Codonopsis pilosula (Franch.) Nannf. However, the pharmacological targets and mechanisms of action of LBT against allergic rhinitis (AR) are not known. The aim of this study was to evaluate the possible functional role and potential mechanism of LBT as an anti-AR treatment through a combination of network pharmacology and molecular docking. The disease database and target screening database were used to find potential targets for screening LBT for the treatment of AR. Further network visualization analysis, g

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Ueda, Hiroshi. "Prothymosin α Plays Role as a Brain Guardian through Ecto-F1 ATPase-P2Y12 Complex and TLR4/MD2". Cells 12, № 3 (2023): 496. http://dx.doi.org/10.3390/cells12030496.

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Prothymosin alpha (ProTα) was discovered to be a necrosis inhibitor from the conditioned medium of a primary culture of rat cortical neurons under starved conditions. This protein carries out a neuronal cell-death-mode switch from necrosis to apoptosis, which is, in turn, suppressed by a variety of neurotrophic factors (NTFs). This type of NTF-assisted survival action of ProTα is reproduced in cerebral and retinal ischemia–reperfusion models. Further studies that used a retinal ischemia–reperfusion model revealed that ProTα protects retinal cells via ecto-F1 ATPase coupled with the Gi-coupled

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Eason, Matthew K., Se-Jong Lee, Poornima Dubey, Anthony Kim, Konstantinos Konstantopoulos, and Aikaterini Kontrogianni-Konstantopoulos. "Abstract B023: Ectopic Expression of the Obscurin PH-domain in Aggressive Breast Cancer Cells Modulates PI3K/Akt Activity and Inhibits Cellular Migration and Invasion." Cancer Research 84, no. 3_Supplement_1 (2024): B023. http://dx.doi.org/10.1158/1538-7445.advbc23-b023.

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Abstract New therapies targeting metastatic spread are greatly needed to improve breast cancer patient survival. Recently, obscurin, an ~800kDa protein localized to the cell membrane, has risen to the spotlight as an overlooked metastasis suppressor commonly lost in breast cancer. Specifically, breast epithelial cells lacking obscurin undergo epithelial-mesenchymal transition (EMT) and demonstrate increased migration and invasion. Biochemical studies in our lab have linked breast epithelial obscurin loss to increased activation of the pro-metastatic PI3K/Akt signaling pathway. Mechanistically,

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Li, Guoqiang, Yanping Liu, Jingru Yao, et al. "Biophysical model for high-throughput tumor and epithelial cell co-culture in complex biochemical microenvironments." Chinese Physics B 31, no. 2 (2021): 028703. http://dx.doi.org/10.1088/1674-1056/ac381c.

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The in vivo tumor microenvironment is a complex niche that includes heterogeneous physical structures, unique biochemical gradients and multiple cell interactions. Its high-fidelity in vitro reconstruction is of fundamental importance to improve current understandings of cell behavior, efficacy predictions and drug safety. In this study, we have developed a high-throughput biochip with hundreds of composite extracellular matrix (ECM) microchambers to co-culture invasive breast cancer cells (MDA-MB-231-RFP) and normal breast epithelial cells (MCF-10A-GFP). The composite ECM is composed of type

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Basu, Kaustuv, and Luc Mongeau. "Hyaluronic acid hydrogel to modulate tumor cell clustering and programmed death ligand 1 signaling in cancer stem cells." Journal of Clinical Oncology 42, no. 16_suppl (2024): e14584-e14584. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e14584.

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e14584 Background: The root of malignancy lies in the extracellular matrix (ECM) surrounding the stromal cells. Thus, current therapeutic targets manipulate abnormal tumor microenvironments (TME), which nourish cancer stem cells (CSC) and induce tumor cell clustering (TCC). Notably, despite the first line of clinical therapy with surgery and chemotherapy, uncontrolled self-renewal of CSCs, conversion of non-CSCs to CSCs, and TCC trigger cancer recurrence. The transmembrane glycoprotein CD44 is thought to be a potential master regulator in cancer recurrence as it interacts with hyaluronic acid

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Jiang, Feng, Hong Wang, Tsz-Lun Yeung та ін. "609 Combining bintrafusp alfa with abituzumab enhances suppression of the TGF-β signaling pathway". Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A639. http://dx.doi.org/10.1136/jitc-2021-sitc2021.609.

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BackgroundBintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor fused to a human IgG1 antibody blocking PD-L1. The TGF-βRII moiety of bintrafusp alfa functions as a ”trap” to sequester active TGF-β but does not block TGF-β release from its latent form. Multiple mechanisms lead to the release of active TGF-β. Integrins control local activation of latent TGF-β stored in the extracellular matrix and cell-surface reservoirs in the tumor microenvironment (TME). Alpha v integrin mRNA expression is correlated with multiple TGF-β

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S., Senthil Kumar, M.Parthiban, and Agastian P. "Immunoprotection studies using Leptospiral recombinant proteins from L. interrogans Icterohaemorrhagiae in hamster models : A synergistic approach." Biolife 4, no. 4 (2022): 678–86. https://doi.org/10.5281/zenodo.7350368.

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<strong>ABSTRACT</strong> Major immunodominant proteins of <em>Leptospira interrogans</em> Icterohaemorrahagiae were cloned, expressed in prokaryotic system was purified and confirmed by western blot. The protective efficacy of purified recombinant proteins were assayed synergistically with adjuvant in hamster models. Three combination were assessed for homologous protection (i.e, r<em>Lip</em>L41, r<em>Omp</em>L1, r<em>Hap</em>I and r<em>Sph</em>H; r<em>Lip</em>L41, r<em>Omp</em>L1, r<em>Lig</em>A and r<em>Lig</em>B; r<em>Lig</em>A, r<em>Lig</em>B, r<em>Hap</em>I and r<em>Sph</em>H) each prot

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Maheswari, J. Uma, Purva Mujumdar, S. P. Sreenivas Padala, and Abhishek Gwaskoti. "BDM–MDM integrated solution concept for scheduling information-driven projects." Engineering, Construction and Architectural Management ahead-of-print, ahead-of-print (2021). http://dx.doi.org/10.1108/ecam-07-2020-0484.

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PurposeScheduling in information-driven design phase of construction projects is challenging due to multiple entity types (teams, components, deliverables, activities or parameters) and their dependencies/linkages. Established techniques such as dependency structure matrix (DSM), beeline diagramming method (BDM), multiple domain matrix (MDM), etc. have been independently utilized in past to model information dependencies/linkages and associated iteration. However, there has not been a holistic solution yet for scheduling multiple entity types and their relationships. Hence, an integrated solut

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Dissertations / Theses on the topic "Multiple-Domain Matrix (MDM)"

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Mujumdar, Purva. "Modeling design interdependency and iteration for multiple two-way information exchanges in construction projects." Thesis, 2017. http://localhost:8080/iit/handle/2074/7489.

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Conference papers on the topic "Multiple-Domain Matrix (MDM)"

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Kreimeyer, Matthias, Stefanie Braun, Matthias Gu¨rtler, and Udo Lindemann. "Relating Two Domains via a Third: An Approach to Overcome Ambiguous Attributions Using Multiple Domain Matrices." In ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/detc2008-49249.

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Design Structure Matrices (DSM) and Domain Mapping Matrices (DMM) are commonly used to model and analyze the relationships within one domain (DSM) or between two domains (DMM). Being assembled into one larger square matrix, having DSMs on its diagonal and DMMs in all other fields, a so-called Multiple Domain Matrix (MDM) is formed. When relating two domains using a DMM, a problem arises when the nature of one individual relationship between the two domains is to be described. Usually, this is modeled by annotating each relationship with the additional information, much like comments in spreads

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Ye, Yun, Marija Jankovic, and Jean-Claude Bocquet. "Managing Semantic Consistency in Model-Based Systems Engineering Using a Matrix Structure." In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-70249.

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Model-Based Systems Engineering (MBSE) currently lacks a formalized way of managing modeling consistency. This paper presents a new methodology for semantic consistency management in MBSE. At its core, a matrix structure which extends the Multiple Domain Matrix (MDM) and Engineering Systems Matrix (ESM) is used to organize semantic relations between modeling elements created by using various modeling languages and tools, and to represent how they change over time. In addition, this paper describes how the new matrix can be automatically maintained by a plug-in module which manages the bidirect

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Wilschut, T., L. F. P. Etman, J. E. Rooda, and J. A. Vogel. "Multi-Level Function Specification and Architecture Analysis Using ESL: A Lock Renovation Pilot Study." In ASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/detc2018-85191.

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In this paper, we present a pilot study to show the first proof-of-principle of the recently developed Elephant Specification Language (ESL). The Prinses Marijke locks in the Netherlands are due for a major renovation. To effectively organize the renovation project, engineers need insight into the network of dependencies between components that are due for renewal and components that remain, to ensure that the replacement parts will fit and function properly in the existing structure. ESL is used to write a structured multi-level function specification for the Prinses Marijke locks. From this

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Eichinger, Markus, Maik Maurer, Udo Pulm, and Udo Lindemann. "Extending Design Structure Matrices and Domain Mapping Matrices by Multiple Design Structure Matrices." In ASME 8th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2006. http://dx.doi.org/10.1115/esda2006-95266.

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Design Structure Matrices (DSMs) and Domain Mapping Matrices (DMMs) are generally used by designers for dynamic optimization of engineering design processes and products. Both methodologies help producing valuable results; however, they are lacking a holistic view onto the processes and products. Dependencies that span multiple product development domains can therefore not be recognized with isolated DSM or DMM analysis. In this paper, we present an integrative approach that combines DSMs and DMMs to obtain the Multiple Design Structure Matrix (MDSM). This methodology offers the possibility to

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