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Journal articles on the topic 'Multiple-Domain Matrix (MDM)'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Juranić, J., N. Pavković, and D. Jurinić. "MANAGEMENT OF DESIGN ITERATIONS ON COUPLED PARAMETERS IN DESIGN TEAMWORK USING MULTIPLE DOMAIN MATRIX AND COLOURED PETRI NETS." Proceedings of the Design Society: DESIGN Conference 1 (May 2020): 617–26. http://dx.doi.org/10.1017/dsd.2020.264.

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AbstractA new way of structuring and interpretation of multiple domain matrix is proposed as the basis for categorisation of design parameter relations complexity. Depending on the kind and the degree of coupling of the parameters, the developed methodology activates the appropriate coloured Petri net (CPN) models for semi-automatic support of communication between the members of the design team. The proposed extension of MDM combined with CPN is a novel approach to predicting and managing communication patterns necessary during teamwork coordination on critical interfaces between product comp

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Shen, Yifan, Jianyong Zhang, Shuchao Mi, Guofang Fan, and Muguang Wang. "Efficient Frequency-Domain Block Equalization for Mode-Division Multiplexing Systems." Photonics 12, no. 2 (2025): 161. https://doi.org/10.3390/photonics12020161.

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In this paper, an adaptive frequency-domain block equalizer (FDBE) implementing the adaptive moment estimation (Adam) algorithm is proposed for mode-division multiplexing (MDM) optical fiber communication systems. By packing all frequency components into frequency-dependent blocks of a specified size B, we define an adaptive equalization matrix to simultaneously compensate for multiple frequency components at each block, which is computed iteratively using the Adam, recursive least squares (RLS) and least mean squares (LMS) algorithms. Simulations show that the proposed FDBE using the Adam alg

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Hou, Li, Jing Yang, Yanrong Li, et al. "Exploring the mechanism of action of Lobetyolin in the treatment of allergic rhinitis based on network pharmacology and molecular docking." Medicine 104, no. 7 (2025): e41496. https://doi.org/10.1097/md.0000000000041496.

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Lobetyolin (LBT) is an important active ingredient in the traditional medicinal plant Codonopsis pilosula (Franch.) Nannf. However, the pharmacological targets and mechanisms of action of LBT against allergic rhinitis (AR) are not known. The aim of this study was to evaluate the possible functional role and potential mechanism of LBT as an anti-AR treatment through a combination of network pharmacology and molecular docking. The disease database and target screening database were used to find potential targets for screening LBT for the treatment of AR. Further network visualization analysis, g

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Ueda, Hiroshi. "Prothymosin α Plays Role as a Brain Guardian through Ecto-F1 ATPase-P2Y12 Complex and TLR4/MD2". Cells 12, № 3 (2023): 496. http://dx.doi.org/10.3390/cells12030496.

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Prothymosin alpha (ProTα) was discovered to be a necrosis inhibitor from the conditioned medium of a primary culture of rat cortical neurons under starved conditions. This protein carries out a neuronal cell-death-mode switch from necrosis to apoptosis, which is, in turn, suppressed by a variety of neurotrophic factors (NTFs). This type of NTF-assisted survival action of ProTα is reproduced in cerebral and retinal ischemia–reperfusion models. Further studies that used a retinal ischemia–reperfusion model revealed that ProTα protects retinal cells via ecto-F1 ATPase coupled with the Gi-coupled

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Eason, Matthew K., Se-Jong Lee, Poornima Dubey, Anthony Kim, Konstantinos Konstantopoulos, and Aikaterini Kontrogianni-Konstantopoulos. "Abstract B023: Ectopic Expression of the Obscurin PH-domain in Aggressive Breast Cancer Cells Modulates PI3K/Akt Activity and Inhibits Cellular Migration and Invasion." Cancer Research 84, no. 3_Supplement_1 (2024): B023. http://dx.doi.org/10.1158/1538-7445.advbc23-b023.

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Abstract New therapies targeting metastatic spread are greatly needed to improve breast cancer patient survival. Recently, obscurin, an ~800kDa protein localized to the cell membrane, has risen to the spotlight as an overlooked metastasis suppressor commonly lost in breast cancer. Specifically, breast epithelial cells lacking obscurin undergo epithelial-mesenchymal transition (EMT) and demonstrate increased migration and invasion. Biochemical studies in our lab have linked breast epithelial obscurin loss to increased activation of the pro-metastatic PI3K/Akt signaling pathway. Mechanistically,

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6

Li, Guoqiang, Yanping Liu, Jingru Yao, et al. "Biophysical model for high-throughput tumor and epithelial cell co-culture in complex biochemical microenvironments." Chinese Physics B 31, no. 2 (2021): 028703. http://dx.doi.org/10.1088/1674-1056/ac381c.

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The in vivo tumor microenvironment is a complex niche that includes heterogeneous physical structures, unique biochemical gradients and multiple cell interactions. Its high-fidelity in vitro reconstruction is of fundamental importance to improve current understandings of cell behavior, efficacy predictions and drug safety. In this study, we have developed a high-throughput biochip with hundreds of composite extracellular matrix (ECM) microchambers to co-culture invasive breast cancer cells (MDA-MB-231-RFP) and normal breast epithelial cells (MCF-10A-GFP). The composite ECM is composed of type

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7

Basu, Kaustuv, and Luc Mongeau. "Hyaluronic acid hydrogel to modulate tumor cell clustering and programmed death ligand 1 signaling in cancer stem cells." Journal of Clinical Oncology 42, no. 16_suppl (2024): e14584-e14584. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e14584.

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e14584 Background: The root of malignancy lies in the extracellular matrix (ECM) surrounding the stromal cells. Thus, current therapeutic targets manipulate abnormal tumor microenvironments (TME), which nourish cancer stem cells (CSC) and induce tumor cell clustering (TCC). Notably, despite the first line of clinical therapy with surgery and chemotherapy, uncontrolled self-renewal of CSCs, conversion of non-CSCs to CSCs, and TCC trigger cancer recurrence. The transmembrane glycoprotein CD44 is thought to be a potential master regulator in cancer recurrence as it interacts with hyaluronic acid

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Jiang, Feng, Hong Wang, Tsz-Lun Yeung та ін. "609 Combining bintrafusp alfa with abituzumab enhances suppression of the TGF-β signaling pathway". Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A639. http://dx.doi.org/10.1136/jitc-2021-sitc2021.609.

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BackgroundBintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor fused to a human IgG1 antibody blocking PD-L1. The TGF-βRII moiety of bintrafusp alfa functions as a ”trap” to sequester active TGF-β but does not block TGF-β release from its latent form. Multiple mechanisms lead to the release of active TGF-β. Integrins control local activation of latent TGF-β stored in the extracellular matrix and cell-surface reservoirs in the tumor microenvironment (TME). Alpha v integrin mRNA expression is correlated with multiple TGF-β

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9

S., Senthil Kumar, M.Parthiban, and Agastian P. "Immunoprotection studies using Leptospiral recombinant proteins from L. interrogans Icterohaemorrhagiae in hamster models : A synergistic approach." Biolife 4, no. 4 (2022): 678–86. https://doi.org/10.5281/zenodo.7350368.

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<strong>ABSTRACT</strong> Major immunodominant proteins of <em>Leptospira interrogans</em> Icterohaemorrahagiae were cloned, expressed in prokaryotic system was purified and confirmed by western blot. The protective efficacy of purified recombinant proteins were assayed synergistically with adjuvant in hamster models. Three combination were assessed for homologous protection (i.e, r<em>Lip</em>L41, r<em>Omp</em>L1, r<em>Hap</em>I and r<em>Sph</em>H; r<em>Lip</em>L41, r<em>Omp</em>L1, r<em>Lig</em>A and r<em>Lig</em>B; r<em>Lig</em>A, r<em>Lig</em>B, r<em>Hap</em>I and r<em>Sph</em>H) each prot

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10

Maheswari, J. Uma, Purva Mujumdar, S. P. Sreenivas Padala, and Abhishek Gwaskoti. "BDM–MDM integrated solution concept for scheduling information-driven projects." Engineering, Construction and Architectural Management ahead-of-print, ahead-of-print (2021). http://dx.doi.org/10.1108/ecam-07-2020-0484.

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PurposeScheduling in information-driven design phase of construction projects is challenging due to multiple entity types (teams, components, deliverables, activities or parameters) and their dependencies/linkages. Established techniques such as dependency structure matrix (DSM), beeline diagramming method (BDM), multiple domain matrix (MDM), etc. have been independently utilized in past to model information dependencies/linkages and associated iteration. However, there has not been a holistic solution yet for scheduling multiple entity types and their relationships. Hence, an integrated solut

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11

Yoonjung, An, and Park Yongtae. "A Framework for Designing Complex Product- Service Systems with a Multi-Domain Matrix." March 1, 2015. https://doi.org/10.5281/zenodo.1100156.

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Offering a Product-Service System (PSS) is a well-accepted strategy that companies may adopt to provide a set of systemic solutions to customers. PSSs were initially provided in a simple form but now take diversified and complex forms involving multiple services, products and technologies. With the growing interest in the PSS, frameworks for the PSS development have been introduced by many researchers. However, most of the existing frameworks fail to examine various relations existing in a complex PSS. Since designing a complex PSS involves full integration of multiple products and services, i

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12

"Analysis and Identification of Putative Novel Peptides Purified from Iranian Endemic Echis Carinatus Sochureki Snake Venom by MALDI-TOF Mass Spectrometry." Archives of Razi Institute, May 23, 2023, 1503–27. http://dx.doi.org/10.32592/ari.2023.78.5.1503.

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The Iranian Echis Carinatus (IEC) venom is an exclusive natural source of bio-substances for a wide range of purposes in the blood coagulation cascade. The present study for the first time was aimed to assess novel pro-coagulant, anti-coagulant and anti-platelet proteins, named EC1.5 (a), EC5.1 (b) and EC4 (a) from Iranian Echis Carinatus (IEC) venom.These peptides were purified by multi-step chromatography methods. Hematological properties were measured using activated clotting tests, platelet aggregation studies, and hemorrhage assessment. Subsequently, these proteins were identified through

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13

Yang, Chen, Chuang Peng, Lei Chen, and Kuangrong Hao. "Multi-level deep domain adaptive adversarial model based on tensor-train decomposition for industrial time series forecasting." Measurement Science and Technology, November 22, 2023. http://dx.doi.org/10.1088/1361-6501/ad0f0f.

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Abstract The polyester industry is a complex process industry, building a time series prediction model for new production lines or equipment with new sensors can be challenging due to a lack of historical data. The time-series data collected from sensors cross-production-line often exhibit varying distributions. Current domain adaptation approaches in data-driven time series forecasting primarily concentrate on adjusting either the features or the models, neglecting the intricacies of industrial time series data. Furthermore, constructing deep neural networks for industrial data necessitates s

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14

Yadav, Vinay Surendra, A. R. Singh, Rakesh D. Raut, and Naoufel Cheikhrouhou. "Blockchain drivers to achieve sustainable food security in the Indian context." Annals of Operations Research, November 11, 2021. http://dx.doi.org/10.1007/s10479-021-04308-5.

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AbstractBlockchain has the potential to improve sustainable food security due to its unique features like traceability, decentralized and immutable database, and smart contract mechanisms. However, blockchain technology is still in the early stages of adoption in particular in agricultural applications. In this context, this article aims to identify blockchain drivers to achieve sustainable food security in the Indian context and model them using an integrated MCDM (Multiple Criteria Decision Making) approach. The blockchain adoption drivers are identified through an exhaustive literature revi

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15

Wang, Zhiyuan, Mahmut Baydaş, Željko Stević, et al. "Comparison of fuzzy and crisp decision matrices: An evaluation on PROBID and sPROBID multi-criteria decision-making methods." Demonstratio Mathematica 56, no. 1 (2023). http://dx.doi.org/10.1515/dema-2023-0117.

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Abstract The use of multi-criteria decision-making (MCDM) methods to select the most appropriate one from a range of alternatives considering multiple criteria is a suitable methodology for making informed decisions. When constructing a decision or objective matrix (DOM) for MCDM procedure, either crisp numerical values or fuzzy linguistic terms can be used. A review of relevant literature indicates that decision experts often prefer to give linguistic terms (instead of crisp numerical values) based on their domain knowledge, to establish a fuzzy DOM. However, previous research articles have n

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16

Mitra, Ashis. "Selection of Khadi fabrics for optimal comfort properties using multi-criteria decision-making technique." Research Journal of Textile and Apparel, January 5, 2022. http://dx.doi.org/10.1108/rjta-08-2021-0108.

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Purpose Khadi fabrics are known for their unique comfort properties which are attributed to their unique structural and functional properties. For getting optimal comfort from a collection of available Khadi fabrics, further exploration is needed. Ranking the Khadi fabrics from a competitive lot for optimal comfort is a challenging job, which has not been addressed so far by any researcher. The purpose of this study is to present one such selection problem using the multi-criteria decision-making (MCDM) technique, a popular branch of operations research, which can handle almost any decision pr

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