Relevant bibliographies by topics / Multiple endpoints / Dissertations / Theses
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Dissertations / Theses on the topic 'Multiple endpoints'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Liu, Yi. "Testing for Efficacy for Primary and Secondary Endpoints by Partitioning Decision Paths." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1259598621.

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2

James, Susan Elizabeth. "The analysis of multiple endpoints in clinical trials." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/34548.

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3

Zain, Zakiyah. "Combining multiple survival endpoints within a single statistical analysis." Thesis, Lancaster University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618302.

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The aim of this thesis is to develop methodology for combining multiple endpoints within a single statistical analysis that compares the responses of patients treated with a novel treatment with those of control patients treated conventionally. The focus is on interval-censored bivariate survival data, and five real data sets from previous studies concerning multiple responses are used to illustrate the techniques developed. The background to survival analysis is introduced by a general description of survival data, and an overview of existing methods and underlying models is included. A revie
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4

Pallmann, Philip Steffen [Verfasser]. "Multiple contrast tests with repeated and multiple endpoints : with biological applications / Philip Steffen Pallmann." Hannover : Technische Informationsbibliothek (TIB), 2016. http://d-nb.info/1112948635/34.

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5

Ntambwe, Lupetu Ives. "Sequential sample size re-estimation in clinical trials with multiple co-primary endpoints." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/66339/.

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In this thesis, we consider interim sample size adjustment in clinical trials with multiple co-primary continuous endpoints. We aim to answer two questions: First, how to adjust a sample size in clinical trial with multiple continuous co-primary endpoints using adaptive and group sequential design. Second, how to construct a test in order to control the family-wise type I error rate and maintain the power, even if the correlation ρ between endpoints is not known. To answer the first question, we conduct K different interim tests, each for one endpoint and each at level α/K (i.e. Bonferroni adj
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6

Nyirabahizi, Epiphanie. "Bayesian and Frequentist Approaches for the Analysis of Multiple Endpoints Data Resulting from Exposure to Multiple Health Stressors." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/136.

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In risk analysis, Benchmark dose (BMD)methodology is used to quantify the risk associated with exposure to stressors such as environmental chemicals. It consists of fitting a mathematical model to the exposure data and the BMD is the dose expected to result in a pre-specified response or benchmark response (BMR). Most available exposure data are from single chemical exposure, but living objects are exposed to multiple sources of hazards. Furthermore, in some studies, researchers may observe multiple endpoints on one subject. Statistical approaches to address multiple endpoints problem can be p
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7

Farhat, Naha. "Design and Analysis of Toxicological Experiments with Multiple Endpoints and Synergistic and Inhibitory Effects." VCU Scholars Compass, 2014. https://scholarscompass.vcu.edu/etd/636.

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The enormous increase of exposure to toxic materials and hazardous chemicals in recent years is a major concern due to the adverse effect resulting from such exposure on human health specifically and all organisms in general. Among the major concerns of toxicologists is to determine an acceptable level(s) of exposure to such hazardous substance(s). Current approaches often evaluate each endpoint and stressor individually. Herein we propose two novel approaches to simultaneously determine the Benchmark Dose Tolerable Region (BMDTR) for multiple endpoints and multiple stressors studies when stre
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8

Walker, Ann Sarah. "The analysis of multivariate failure time data with application to multiple endpoints in trials in HIV infection." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390624.

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9

Hieke-Schulz, Stefanie [Verfasser], and Martin [Akademischer Betreuer] Schumacher. "Statistical modeling strategies for linking multiple molecular sources to time-to-event endpoints = Statistische Modellbildungsstrategien zur Verknüpfung multipler molekularer Quellen unter Berücksichtigung von Time-to-Event Endpunkten." Freiburg : Universität, 2014. http://d-nb.info/1123480672/34.

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10

Riou, Jérémie. "Multiplicité des tests, et calculs de taille d'échantillon en recherche clinique." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22066/document.

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Ce travail a eu pour objectif de répondre aux problématiques inhérentes aux tests multiples dans le contexte des essais cliniques. A l’heure actuelle un nombre croissant d’essais cliniques ont pour objectif d’observer l’effet multifactoriel d’un produit, et nécessite donc l’utilisation de co-critères de jugement principaux. La significativité de l’étude est alors conclue si et seulement si nous observons le rejet d’au moins r hypothèses nulles parmi les m hypothèses nulles testées. Dans ce contexte, les statisticiens doivent prendre en compte la multiplicité induite par cette pratique. Nous no
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11

Kalra, Jessica. "Integrin Linked Kinase as a therapeutic target for treating breast cancer : the value of using multiple endpoints to assess therapeutic effects of targeted drugs and drug combinations." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27023.

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Substantial preclinical evidence indicates that inhibition of Integrin Linked-Kinase (ILK) correlates with cytotoxic/cytostatic cellular effects, delayed tumour growth in animal models of cancer and inhibition of angiogenesis. It is increasingly evident that optimal therapeutic benefits obtained using ILK targeting strategies will only be achieved in combination settings. For this reason the therapeutic potential of the ILK small molecule inhibitor, QLT0267, alone or in combination with chemotherapies commonly used to treat breast cancer patients was investigated. The results suggested that th
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12

Qin, Lang. "Magnetic resonance imaging lesion count as a surrogate endpoint in relapsing-remitting multiple sclerosis clinical trials." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37092.

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The count of active lesions based on magnetic resonance imaging (MRI) is often used as a potential surrogate endpoint in phase 2 clinical trials for relapsing-remitting multiple sclerosis (RRMS) patients. However, this surrogacy relationship has not been completely validated. In this report, we study whether at the trial level, the MRI lesion count is a good surrogate endpoint for the relapse rate, the usual clinical endpoint for RRMS clinical trials. Two different approaches to assess this surrogacy relationship are applied to the dataset used by Sormani et al. [1] (SBRCMB) which contains th
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13

Truisi, Germaine Loredana [Verfasser], and S. O. [Akademischer Betreuer] Müller. "A multiple endpoint approach to predict the hepatotoxicity of pharmaceuticals in vitro / Germaine Loredana Truisi. Betreuer: S. O. Müller." Karlsruhe : KIT-Bibliothek, 2014. http://d-nb.info/1054989419/34.

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14

Yang, Yijun. "Evaluating multiple endpoints in heart failure clinical trials." Thesis, 2015. https://hdl.handle.net/2144/15649.

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The selection of the best response variables in a clinical trial is often not straightforward; the primary endpoint of a trial should be clinically relevant, directly related to the primary objective of the trial, and with favorable efficiency to detect the treatment benefit with a reasonable sample size and duration of the trial. With the recent success in the management of heart failure, the mortality rate has dropped significantly compared to two decades ago, and patients with heart failure have high rates of hospitalization and morbid complications along with multiple symptoms and severe l
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15

Hofmann, Candace Erica. "Effects of prenatal ethanol exposure in rats on multiple endpoints of central serotonergic function." Thesis, 2002. http://hdl.handle.net/2429/14868.

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Maternal consumption of alcohol during pregnancy produces a wide range of abnormalities in the offspring. The main objective of this thesis was to examine long-term functional changes in central 5-HT receptor function of female and male rats prenatally exposed to ethanol. Serotonin receptor function was assessed through pharmacological challenge with the 5-HT[sub 1A] and 5-HT[sub 2A] receptor agonists 8-hydroxy-2-(di-npropylamino) tetralin (8-OH-DPAT) and (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), respectively. Adult offspring of Sprague-Dawley rats from prenatal et
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16

Delorme, Philippe. "Approximation du calcul de la taille échantillonnale pour les tests à hypothèses multiples lorsque r parmis m hypothèses doivent être significatives." Thèse, 2012. http://hdl.handle.net/1866/9118.

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Généralement, dans les situations d’hypothèses multiples on cherche à rejeter toutes les hypothèses ou bien une seule d’entre d’elles. Depuis quelques temps on voit apparaître le besoin de répondre à la question : « Peut-on rejeter au moins r hypothèses ? ». Toutefois, les outils statisques pour répondre à cette question sont rares dans la littérature. Nous avons donc entrepris de développer les formules générales de puissance pour les procédures les plus utilisées, soit celles de Bonferroni, de Hochberg et de Holm. Nous avons développé un package R pour le calcul de la taille échantilonnalle
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17

Huang, Wong-Shian, and 黃翁賢. "Application of Multivariate Random Effect Model to Multivariate Meta-analysis and Multiregional Clinical Trials with Multiple Endpoints." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/x5kkc2.

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博士<br>國立交通大學<br>統計學研究所<br>105<br>In some therapeutic areas, the clinical efficacy of a new treatment may be evaluated by a set of possibly correlated endpoints. For example, the main endpoints for Alzheimer’s disease are usually referred to cognitive test, activities of daily living, and global assessment of change. In this thesis, our aim is to deal with two issues based on the consideration for multiple endpoints in clinical trials: (1) the conventional approaches for the multivariate meta-analysis (MMA) having heterogeneous covariances across different trials may have a less accuracy of e
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18

Cheng, Yansong. "Some recent advances in multivariate statistics: modality inference and statistical monitoring of clinical trials with multiple co-primary endpoints." Thesis, 2014. https://hdl.handle.net/2144/14285.

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This dissertation focuses on two topics in multivariate statistics. The first part develops an inference procedure and fast computation tool for the modal clustering method proposed by Li et al. (2007). The modal clustering, based on the kernel density estimate, clusters data using their associations within a single mode, with the final number of clusters equaling the number of modes, otherwise known as the modality of the distribution of the data. This method provides a flexible tool for clustering data of low to moderate dimensions with arbitrary distributional shapes. In contrast to Li an
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19

"The relationships between sex differences in learning strategy in early life and neurochemical and neuroarchitectural endpoints in multiple memory systems." Tulane University, 2013.

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Rodents solve dual-solution tasks that require navigation to a goal by adopting either a hippocampus-dependent place strategy or a striatum-dependent stimulus–response strategy. The current experiments investigated the preference for learning strategy as a function of biological sex and anxiety level in rats prior to the onset of puberty, before the activational effects of gonadal hormones influence these processes. In the first experiment, a significant proportion of prepubertal males preferred a stimulus-response strategy on a dual-solution visible platform water maze task at 28 days of age,
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