Log in

Relevant bibliographies by topics / Multiple myeloma; Breast cancer / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Multiple myeloma; Breast cancer.

Dissertations / Theses on the topic 'Multiple myeloma; Breast cancer'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Multiple myeloma; Breast cancer.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Drake, Mary. "Characterisation of mononuclear cells in peripheral blood stem cell harvests." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287206.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Harrison, Simon James. "Immunotherapy in multiple myeloma." Thesis, University of Glasgow, 2005. http://theses.gla.ac.uk/1054/.

Full text

Abstract:

The BDCA antibodies allowed reliable measurement of dendritic cell (DC) subsets and B cell numbers in the blood of normal subjects, and patients with MM throughout the disease course. The numbers of blood myeloid DC (BmDC) and blood plasmacytoid DC (BpDC) are low throughout the course of the disease, and only improve for a short period of time following autologous HSCT. Thalidomide therapy of patients with relapsed disease was associated with an increase in BmDC1 and BpDC numbers. Monocytes, mobilised at the time of stem cell collection, were used to produce mature DC (matDC) from MM patients

APA, Harvard, Vancouver, ISO, and other styles

3

Dimberg, Lina. "Apoptosis Regulation in Multiple Myeloma." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7099.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Mhadgut, Hemendra M. D., Alay Mansurov, Rabia Zafar, and Koyamangalath Krishnan. "Liver Mass: An Unusual Presentation of Multiple Myeloma." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/22.

Full text

Abstract:

Multiple myeloma is characterized by proliferation of plasma cells in the bone marrow, producing monoclonal immunoglobulin. It accounts for 17% of hematologic malignancies in the US. Diagnosis is often suspected in the setting of bone lytic lesions, anemia, hypercalcemia or renal failure. Rarely, multiple myeloma can present with soft tissue involvement which can be difficult to diagnose. Below we present one such presentation. Our patient is a 53-year-old who was initially diagnosed with multiple myeloma six years back when he presented to hospital with back and right leg pain. On admission h

APA, Harvard, Vancouver, ISO, and other styles

5

Cook, Gordon. "Immune regulation in multiple myeloma : the host-tumour conflict." Thesis, University of Glasgow, 2000. http://theses.gla.ac.uk/6140/.

Full text

Abstract:

The data presented in this thesis demonstrates that the malignant plasma cells of multiple myeloma are capable of suppressing the activation of T lymphocytes. The myeloma cells prevent activation of T cells from healthy donors by allo-antigen, mitogen and IL-2, mediated by the production of soluble, immuno-suppressive factor. This factor was responsible for inducing cell cycle arrest and failure of the T cells to progress into the autocrine IL-2 autocrine pathway, which is of critical importance in the activation of T cells. To further investigate this interaction an in vitro model system was

APA, Harvard, Vancouver, ISO, and other styles

6

Okumura, Setsuko. "Feasibility of breast-conserving therapy for macroscopically multiple breast cancer." Kyoto University, 2004. http://hdl.handle.net/2433/147559.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Faiman, Beth Marie. "Peripheral Neuropathy and Diarrhea Symptoms in Multiple Myeloma." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1417619492.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Machin, Reinaldo Franqui. "Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6104.

Full text

Abstract:

Multiple Myeloma (MM) is an incurable plasma cell malignancy and, although novel treatment regimes in the past decade have improved patient outcome, long-term treatment leads to relapse and refractory disease. The centrosomal kinase NEK2 is found overexpressed in MM and promotes chromosomal instability, drug resistance and increased proliferation. Although much research shows NEK2 having a detrimental effect in cancer, much of its mechanisms of overexpression and drug resistance has not been studied in detail. In this work we expand our understanding of NEK2 in MM. Using Tandem Affinity Purifi

APA, Harvard, Vancouver, ISO, and other styles

9

Zabalo, Joaquin. "A Mathematical Model Describing the Early Development of Multiple Myeloma." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/366.

Full text

Abstract:

Multiple myeloma is a malignant bone marrow plasma cell tumor which is responsible for approximately 12,000 deaths per year in the United States and two percent of all cancer deaths. It is recognized clinically by the presence of more than ten percent bone marrow plasma cells, the detection of a monoclonal protein (M-protein), anemia, hypercalcemia, renal insufficiency, and lytic bone lesions. The disease is usually preceded by a premalignant tumor called monoclonal gammopathy of undetermined significance (MGUS), which is present in one percent of adults over the age of fifty, three percent ov

APA, Harvard, Vancouver, ISO, and other styles

10

Kendrick, Felicity. "Modelling immunoglobulin metabolism and its effect on prognostic utility in multiple myeloma." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/104030/.

Full text

Abstract:

Multiple myeloma is a cancer of plasma cells. In multiple myeloma, a clone of plasma cells in the bone marrow secretes a unique, monoclonal immunoglobulin (Ig), whose biological properties depend on its type and structure. The monoclonal Ig offers a convenient opportunity for clinicians to monitor the response of the tumour to therapy via the secreted protein, which is readily quantified in a blood sample. Responses to treatment are assigned based on the percentage reduction in monoclonal Ig; however, response criteria do not take into account the different metabolic half-lives of the proteins

APA, Harvard, Vancouver, ISO, and other styles

11

Dorjsuren, Delgerzul, Holly Abigail Adams, Dawnna Elisabeth Metcalfe, and Victoria E. Palau. "Finding Novel and Synergistic Cytotoxic Agents for the Treatment of Multiple Myeloma." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/180.

Full text

Abstract:

Multiple Myeloma is cancer of plasma cells and is known to be highly invasive. Multiple Myeloma makes up 1% of cancer diagnosis in western countries and affects men more predominantly than women. The American Cancer Association estimates that 32,110 new cases will be diagnosed in the United States in 2019. Lenalidomide is one of the main therapies used for multiple myeloma patients, but it has toxic side effects such as thrombocytopenia, neutropenia, and anemia. The purpose of the study is to investigate new cytotoxic agents for the treatment of multiple myeloma. In addition to lenalidomide al

APA, Harvard, Vancouver, ISO, and other styles

12

Corrias, Maria Elena. "A statistical mechanics approach to cancer dynamics: a model for multiple myeloma bone disease." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18021/.

Full text

Abstract:

L’utilizzo di modelli matematici sta assumendo un ruolo sempre più centrale nella ricerca oncologica. La complessità del cancro ha stimolato gruppi di ricerca interdisciplinare nello sviluppo di modelli quantitativi per rispondere alle numerose domande aperte che riguardano l’insorgenza, la progressione, la diagnosi, la risposta al trattamento terapeutico e l’acquisizione della resistenza ai farmaci dei tumori. La varietà di approcci matematico-fisici ben si adatta allo studio di una materia così eterogenea. In questo lavoro presentiamo innanzitutto gli aspetti biologico-clinici che caratteriz

APA, Harvard, Vancouver, ISO, and other styles

13

Abdalla, Amir Osman. "Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-114-2/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Jacobson, Timothy. "A Trans-Dimensional View of Drug Resistance Evolution in Multiple Myeloma Patients." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6099.

Full text

Abstract:

Multiple Myeloma (MM) is a treatable, yet incurable, malignancy of bone marrowplasma cells. This cancer affects many patients and many succumb to relapse of tumor burden despite a large number of available chemotherapeutic agents developed for therapy. This is because MM tumors are heterogeneous and receive protection from therapeutic agents by the microenvironment and other mechanisms including homologous MM-MM aggregation. Therefore, therapy failure and frequent patient relapse is due to the evolution of drug resistance, not a lack of available drugs. To analyze and understand this problem,

APA, Harvard, Vancouver, ISO, and other styles

15

Goodyear, Oliver Charles. "A study of cancer-germline antigen specific T cell responses in patients with multiple myeloma." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433641.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Turtle, Cameron J. "The CMRF-56+ blood dendritic cell preparation as a vehicle for multiple myeloma immunotherapy /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18657.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Probert, Adam. "The genetic epidemiology of multiple primary breast and ovarian cancer /." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20971.

Full text

Abstract:

Breast and ovarian cancers are among the most common tumours affecting Canadian women. A proportion of these tumours was thought to be due to family history and the breast cancer susceptibility gene and are more likely to occur before the age of 50. It is hypothesized that women who have both primary tumours of the breast and ovary are more likely to have a mutation in this gene. The main objective of this study is to examine the role of family history in those women with breast cancer that subsequently develop ovarian cancer. The role of chemotherapy and radiotherapy in the treatment of breas

APA, Harvard, Vancouver, ISO, and other styles

18

Probert, Adam. "The genetic epidemiology of multiple primary breast and ovarian cancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0024/MQ50860.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Soerjomataram, Isabelle. "Multiple primary cancers in patients with breast ans skin cancer." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10779.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Yeung, Ka Yu. "The role of mitochondrial DNA in the tumor biology of glioblastoma multiforme and multiple myeloma." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/62061/.

Full text

Abstract:

Cancer cells preferentially metabolise glucose via aerobic glycolysis (the Warburg effect), which is less energy efficient in teens of ATP production compared to oxidative phosphorylation (OXPHOS). Mitochondrial DNA (mtDNA) encodes proteins of the electron transfer chain and is crucial for functional OXPHOS. MtDNA exists as multiple copies in cells and, often in cancer, there is co-existence of mutant and wild-type mtDNA. There is evidence for mitochondria to contribute towards the tumor biology of multiple myeloma (MM) and glioblastoma multiforme (GBM). The mtDNA from both these cancer types

APA, Harvard, Vancouver, ISO, and other styles

21

Bagratuni, Tina. "Modulation of endoplasmic reticulum stress as a cancer therapeutic strategy using multiple myeloma as a model." Thesis, Institute of Cancer Research (University Of London), 2010. http://publications.icr.ac.uk/10367/.

Full text

Abstract:

The presence of correctly folded nascent immunoglobulin within the endoplasmic reticulum (ER) provides an effective checkpoint for plasma cell development. A signalling pathway called the unfolded protein response (UPR) allows cells to handle the proper folding of proteins and ensures cell survival. The transcription factor XBP1, a central control point in mediating plasma cell development is also a major regulator of the UPR providing a link between the UPR and plasma cell differentiation. My hypothesis was that inhibition of the UPR and the ER stress pathways will provide a unique differenti

APA, Harvard, Vancouver, ISO, and other styles

22

Adesanya, M. A. "Thrombin generation, tissue factor microvesicles and the endothelium in multiple myeloma and pancreatic cancer during treatment." Thesis, University of York, 2018. http://etheses.whiterose.ac.uk/22051/.

Full text

Abstract:

Cancer and its anti-neoplastic treatment are frequently complicated by venous thromboembolism (VTE) occurrence. Multiple myeloma (MM), a haematological malignancy and Pancreatic cancer (PC), a solid tumour are two common malignancies with similarly high VTE incidence, which worsens during treatment. Thrombin production is a key step in the pathologic evolution of VTE and may play an important role in determining VTE risk in cancer patients. The calibrated automated thrombography (CAT) assay is emerging as a reliable tool for real time estimation of thrombin generation (TG) potential, and there

APA, Harvard, Vancouver, ISO, and other styles

23

Lee, Min Jae. "THE DEVELOPMENT OF NOVEL PROTEASOME INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA AND ALZHEIMER’S DISEASE." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/99.

Full text

Abstract:

Over a decade, proteasome inhibitors (PIs), bortezomib, carfilzomib (Cfz) and ixazomib, have contributed to a significant improvement in the overall survival for multiple myeloma (MM) patients. However, the response rate of PI was fairly low, leaving a huge gap in MM patient care. Given this, mechanistic understanding of PI resistance is crucial towards developing new therapeutic strategies for refractory/relapsed MM patients. In this dissertation work, we found H727 human bronchial carcinoid cells are inherently resistant to Cfz, yet susceptible to other PIs and inhibitors targeting upstream

APA, Harvard, Vancouver, ISO, and other styles

24

Green, Ashley E. "Examination of Genetic Changes Associated with Breast Cancer Disparities Across Multiple Ethnicities." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_theses/284.

Full text

Abstract:

Breast cancer is of a primary concern in women, although it can occur in men. It is the second leading cause of cancer related deaths amongst women, and it is estimated that roughly 39,840 women will die of this disease this year. Breast cancer occurs across all populations and ethnicities. When African-Americans (AA) present with breast cancer, they usually have poorly differentiated tumors, and are more likely to be diagnosed with an advanced stage tumor. When compared to Caucasian (Cau) women, African-American women also have higher breast cancer mortality. The causes of these differen

APA, Harvard, Vancouver, ISO, and other styles

25

Issa, Mark E., E. M. K. Wijeratne, A. A. L. Gunatilaka, and Muriel Cuendet. "Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/625811.

Full text

Abstract:

In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtually all conventional therapies. In this study, the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera, on drug-sensitive tumoral plasma cells and drug-resistant MM cells have been investigated. In MTT/XTT assays, WND exhibited simi

APA, Harvard, Vancouver, ISO, and other styles

26

Lajmi, Nesrine [Verfasser], and Walter [Akademischer Betreuer] Fiedler. "The biological function of Cancer-testis antigen MAGE-C2/CT10 in Multiple Myeloma / Nesrine Lajmi. Betreuer: Walter Fiedler." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1101695935/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Lajmi, Nesrine Verfasser], and Walter [Akademischer Betreuer] [Fiedler. "The biological function of Cancer-testis antigen MAGE-C2/CT10 in Multiple Myeloma / Nesrine Lajmi. Betreuer: Walter Fiedler." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1101695935/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Duhachek, Muggy Sara. "Multiple isoforms of ADAM12 in breast cancer: differential regulation of expression and unique roles in cancer progression." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18685.

Full text

Abstract:

Doctor of Philosophy<br>Department of Biochemistry and Molecular Biophysics<br>Anna Zolkiewska<br>The ADAM (A Disintegrin and Metalloprotease) family of multi-domain proteins modulates a number of cellular signaling pathways in both normal and cancerous cells. ADAM12 has been shown to be a candidate cancer gene for breast cancer and its expression is up-regulated in breast tumors. The human ADAM12 transcript is alternatively spliced. One of these splice variants encodes a transmembrane ADAM12 isoform, ADAM12-L, which has been demonstrated to release cell signaling molecules from the cell surfa

APA, Harvard, Vancouver, ISO, and other styles

29

Christensen, Kimberly Laura. "The developmental regulator SIX1 plays multiple roles in breast cancer initiation and progression /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

Find full text

Abstract:

Thesis (Ph.D. in Biophysics & Genetics, Program in Molecular Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 115-132). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

APA, Harvard, Vancouver, ISO, and other styles

30

Maharaj, Lenushka. "Use of in vitro primary culture models to investigate the activity of standard and novel therapies in haematological malignancies." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8532.

Full text

Abstract:

Despite improved treatments for Non-Hodgkin’s Lymphoma (NHL) and Multiple Myeloma (MM), most patients eventually relapse and these diseases remain largely incurable. This has precipitated recent research into more clinically relevant in vitro models to enable development of more effective therapies. We have validated and standardised two in vitro primary culture models using tumour samples derived from patients with NHL, Chronic Lymphocytic Leukaemia (CLL) and MM. Several novel findings have been demonstrated. In vitro sensitivity of primary NHL cells cocultured in a CD40L model predicted clin

APA, Harvard, Vancouver, ISO, and other styles

31

Rodrigues, Margret S. Tong Alex W. "Growth inhibition of human multiple myeloma cells by a conditional-replicative, oncolytic adenovirus armed with the CD154 (CD40-ligand) transgene." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/5016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Gadaleta, Emanuela. "A multidisciplinary computational approach to model cancer-omics data : organising, integrating and mining multiple sources of data." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8141.

Full text

Abstract:

It is imperative that the cancer research community has the means with which to effectively locate, access, manage, analyse and interpret the plethora of data values being generated by novel technologies. This thesis addresses this unmet requirement by using pancreatic cancer and breast cancer as prototype malignancies to develop a generic integrative transcriptomic model. The analytical workflow was initially applied to publicly available pancreatic cancer data from multiple experimental types. The transcriptomic landscape of comparative groups was examined both in isolation and relative to e

APA, Harvard, Vancouver, ISO, and other styles

33

Wallace, Julie. "Deciphering the Functions of Ets2, Pten and p53 in Stromal Fibroblasts in Multiple Breast Cancer Models." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1365496427.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Sims, Jonathan Thomas. "c-ABL AND ARG DRIVE CANCER CHEMORESISTANCE VIA ACTIVATION OF MULTIPLE SIGNALING PATHWAYS." UKnowledge, 2012. http://uknowledge.uky.edu/pharmacol_etds/1.

Full text

Abstract:

Despite 35 years of clinical trials, there has been little improvement in one-year survival rates with any chemotherapeutic regimen for the treatment of metastatic melanoma due to resistance to all known agents. Regardless of advances in detection and prevention, diagnosis of metastatic disease remains a death sentence. Resistance mechanisms, including aberrant kinase signaling and drug transport pumps, indicate a need for identification of other therapeutic targets that impinge upon multiple signaling pathways. The Abl family of non-receptor tyrosine kinases (c-Abl, Arg) has been indicted as

APA, Harvard, Vancouver, ISO, and other styles

35

Hawkins, William Tressel II. "Combinatorial Modulation of Multiple Signaling Pathways to Gain Therapeutic Response in Breast and Prostate Cell Carcinomas." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1043.

Full text

Abstract:

Our laboratory is primarily interested in novel pharmacological intervention of cell proliferation and survival pathways expressed in various types of cancer. These cyto-protective pathways can be activated in response to growth factor stimulation, toxic insult and radiation. In our studies, we utilized novel drug combinations with and without radiation to enhance breast & prostate tumor cell death both in vitro and in vivo. Previous studies from our group have shown that UCN-01 and MEK1/2 inhibitors interact to cause tumor cell death in transformed cell lines in vitro. We extended this observ

APA, Harvard, Vancouver, ISO, and other styles

36

Moreira, dos Santos Dirley. "Distinguishing the effects of time dependence from the effects of frailty in multiple spell breast cancer data." Thesis, Lancaster University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385269.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Payne, Kyle K. "Immunotherapy of Cancer: Reprogramming Tumor/Immune Cellular Crosstalk to Improve Anti-Tumor Efficacy." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3939.

Full text

Abstract:

Immunotherapy of cancer has been shown to be promising in prolonging patient survival. However, complete elimination of cancer and life-long relapse-free survival remain to be major challenge for anti-cancer therapeutics. We have previously reported that ex vivo reprogramming of tumor-sensitized immune cells by bryostatin 1/ionomycin (B/I) and the gamma-chain (γ-c) cytokines IL-2, IL-7, and IL-15 resulted in the generation of memory T cells as well as CD25+ NKT cells and CD25+ NK cells. Adoptive cellular therapy (ACT) utilizing these reprogrammed immune cells protected FVBN202 mice from tumor

APA, Harvard, Vancouver, ISO, and other styles

38

Puyade, Mathieu. "Parcours de soins des patients atteints d'hémopathies malignes en Poitou-Charentes." Thesis, Poitiers, 2017. http://www.theses.fr/2017POIT1407/document.

Full text

Abstract:

La réduction des inégalités d'accès aux soins a toujours été un axe majeur des politiques de lutte contre le cancer. Alors qu'il existe de nombreuses études en cancérologie solide, peu d'études avec une méthodologie correcte existent en onco-hématologie, notamment chez les patients atteints de Myélome Multiple (MM). Cette maladie a vu son pronostic transformé par l'arrivée de nouvelles thérapeutiques dont l'usage a été rapidement intégré dans les recommandations de la Société Française d'Hématologie. L'objectif de travail intitulé Parcours de Soins des patients atteints d'hémopathie maligne en

APA, Harvard, Vancouver, ISO, and other styles

39

Hartman, Mikael. "Risk and prognosis of breast cancer among women at high risk of the disease /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-303-0/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Tao, Wang. "Adapting multiple datasets for better mammography tumor detection." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-231867.

Full text

Abstract:

In Sweden, women of age between of 40 and 74 go through regular screening of their breasts every 18-24 months. The screening mainly involves obtaining a mammogram and having radiologists analyze them to detect any sign of breast cancer. However reading a mammography image requires experienced radiologist, and the lack of radiologist reduces the hospital's operating efficiency. What's more, mammography from different facilities increases the difficulty of diagnosis. Our work proposed a deep learning segmentation system which could adapt to mammography from various facilities and locate the posi

APA, Harvard, Vancouver, ISO, and other styles

41

Zhao, Helong. "Roles of Slit-Robo Signaling in Pathogenesis of Multiple Human Diseases: HIV-1 Infection, Vascular Endothelial Inflammation and Breast Cancer." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1428088097.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Pliuskys, Laurynas. "Epigenetic regulation of the myeloid cell lineage." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f4ee6659-ce0b-4730-ae5b-95c141f82e10.

Full text

Abstract:

The myeloid cell lineage is a fundamental element of the immune system and it can give rise to a diverse set of terminally differentiated cells, such as macrophages or osteoclasts among many others. Mutations or misregulation of gene expression may lead to severe clinical conditions, such as arthritis, osteoporosis or cancers. Epigenetics, the regulation of gene expression and chromatin remodelling, is implicated in cell differentiation, function and disease, and hence it is a promising new area to explore in order to explain underlying cellular mechanisms. Firstly, human macrophage subtypes w

APA, Harvard, Vancouver, ISO, and other styles

43

Lemaitre, Léa. "Caractérisations phénotypiques et fonctionnelles des cellules stromales mésenchymateuses au cours du traitement du myélome multiple." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30279.

Full text

Abstract:

Le myélome multiple (MM) est une hémopathie caractérisée par l'accumulation de plasmocytes (PC) malins dans la moelle osseuse pouvant occasionner entre autres des lésions ostéolytiques. Il s'agit d'une maladie extrêmement hétérogène, tant au niveau de la présentation clinique, de la réponse aux traitements, de la survie globale, que sur le plan biologique. L'hypothèse actuelle est que cette hétérogénéité est non seulement due à l'énorme variabilité moléculaire présente au sein des cellules tumorales mais également au microenvironnement des PC tumoraux. Dans ce microenvironnement nous nous inté

APA, Harvard, Vancouver, ISO, and other styles

44

Erdem, Munire Tugba. "Modeling Diseases With Multiple Disease Characteristics: Comparison Of Models And Estimation Methods." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613531/index.pdf.

Full text

Abstract:

Epidemiological data with disease characteristic information can be modelled in several ways. One way is taking each disease characteristic as a response and constructing binary or polytomous logistic regression model. Second way is using a new response which consists of disease subtypes created by cross-classification of disease characteristic levels, and then constructing polytomous logistic regression model. The former may be disadvantageous since any possible covariation between disease characteristics is neglected, whereas the latter can capture that covariation behaviour. However, cross

APA, Harvard, Vancouver, ISO, and other styles

45

Allen, Stephanie D. "Therapeutic peptidomimetic strategies for costimulation blockade in multiple sclerosis and transplantation / conformational peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1150479940.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Kalra, Jessica. "Integrin Linked Kinase as a therapeutic target for treating breast cancer : the value of using multiple endpoints to assess therapeutic effects of targeted drugs and drug combinations." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27023.

Full text

Abstract:

Substantial preclinical evidence indicates that inhibition of Integrin Linked-Kinase (ILK) correlates with cytotoxic/cytostatic cellular effects, delayed tumour growth in animal models of cancer and inhibition of angiogenesis. It is increasingly evident that optimal therapeutic benefits obtained using ILK targeting strategies will only be achieved in combination settings. For this reason the therapeutic potential of the ILK small molecule inhibitor, QLT0267, alone or in combination with chemotherapies commonly used to treat breast cancer patients was investigated. The results suggested that th

APA, Harvard, Vancouver, ISO, and other styles

47

Ghanem, Ali [Verfasser], and Stefan [Akademischer Betreuer] Wölfl. "On the Regulation and Multiple Functions of the Key Gluconeogenic Enzyme Fbp1 in Rapidly Proliferating Cells: Insights from Yeast and Breast Cancer Cells / Ali Ghanem ; Betreuer: Stefan Wölfl." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177149605/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Duberg, Ann-Sofi. "Hepatitis C virus infection a nationwide study of associated morbidity and mortality /." Doctoral thesis, Örebro : Örebro universitet, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7835.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Tran, Xuan Quang. "Les modèles de régression dynamique et leurs applications en analyse de survie et fiabilité." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0147/document.

Full text

Abstract:

Cette thèse a été conçu pour explorer les modèles dynamiques de régression, d’évaluer les inférences statistiques pour l’analyse des données de survie et de fiabilité. Ces modèles de régression dynamiques que nous avons considérés, y compris le modèle des hasards proportionnels paramétriques et celui de la vie accélérée avec les variables qui peut-être dépendent du temps. Nous avons discuté des problèmes suivants dans cette thèse.Nous avons présenté tout d’abord une statistique de test du chi-deux généraliséeY2nquiest adaptative pour les données de survie et fiabilité en présence de trois cas,

APA, Harvard, Vancouver, ISO, and other styles

50

Swift, Brenna. "Natural Killer Cell Line Therapy in Multiple Myeloma." Thesis, 2011. http://hdl.handle.net/1807/31456.

Full text

Abstract:

Multiple myeloma (MM) is an incurable plasma cell malignancy. NK cells have demonstrated anti-MM activity in allogeneic transplants and donor lymphocyte infusions, and may provide a more effective therapy for MM. This work demonstrates cytotoxicity of NK-92 and KHYG-1 against MM cells in chromium release and flow cytometry cytotoxicity assays. At a 10:1 effector to target ratio, the cytotoxicity of NK cell lines against MM cells is 50-90%. Blocking NKp30 significantly reduces the cytotoxicity of NK-92 and KHYG-1, while blocking NKG2D and DNAM-1 only reduces the cytotoxicity of NK-92. Notably,

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!