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Journal articles on the topic 'Multiple Organ Dysfunction Syndrome (MODS)'

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Published: 5 June 2025

Last updated: 2 August 2025

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1

Gourd, Nicholas M., and Nikitas Nikitas. "Multiple Organ Dysfunction Syndrome." Journal of Intensive Care Medicine 35, no. 12 (2019): 1564–75. http://dx.doi.org/10.1177/0885066619871452.

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Multiple organ dysfunction syndrome (MODS) is one of the most common syndromes of critical illness and the leading cause of mortality among critically ill patients. Multiple organ dysfunction syndrome is the clinical consequence of a dysregulated inflammatory response, triggered by clinically diverse factors with the main pillar of management being invasive organ support. During the last years, the advances in the clarification of the molecular pathways that trigger, mitigate, and determine the outcome of MODS have led to the increasing recognition of MODS as a distinct disease entity with dis

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Weiss, Scott L., Joseph A. Carcillo, Francis Leclerc, et al. "Refining the Pediatric Multiple Organ Dysfunction Syndrome." Pediatrics 149, Supplement_1 (2022): S13—S22. http://dx.doi.org/10.1542/peds.2021-052888c.

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Since its introduction into the medical literature in the 1970s, the term multiple organ dysfunction syndrome (or some variant) has been applied broadly to any patient with &gt;1 concurrent organ dysfunction. However, the epidemiology, mechanisms, time course, and outcomes among children with multiple organ dysfunction vary substantially. We posit that the term pediatric multiple organ dysfunction syndrome (or MODS) should be reserved for patients with a systemic pathologic state resulting from a common mechanism (or mechanisms) that affects numerous organ systems simultaneously. In contra

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Pang, Diana, Dalia Bashir, Joseph Carcillo, Trung Nguyen, Rajesh Aneja, and Alicia Alcamo. "Role of Damage-Associated Molecular Patterns and Uncontrolled Inflammation in Pediatric Sepsis-Induced Multiple Organ Dysfunction Syndrome." Journal of Pediatric Intensive Care 08, no. 01 (2018): 025–31. http://dx.doi.org/10.1055/s-0038-1675639.

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AbstractThe incidence of multiple organ dysfunction syndrome (MODS) in sepsis varies from 17 to 73% and furthermore, increases the risk of death by 60% when controlled for the number of dysfunctional organs. Several MODS phenotypes exist, each unique in presentation and pathophysiology. Common to the phenotypes is the stimulation of the immune response by pathogen-associated molecular patterns (PAMPs), or danger-associated molecular patterns (DAMPs) causing an unremitting inflammation. Two of the MODS phenotypes are discussed in detail, thrombocytopenia-associated multiple organ failure (TAMOF

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Alam, Mohammad Shaha, and Syeda Humaira Begum. "Multiple Organ Dysfunction Syndrome In Major Burns Patients." Medicine Today 22, no. 2 (2012): 75–79. http://dx.doi.org/10.3329/medtoday.v22i2.12438.

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Organ dysfunctions are frequent after major burn trauma. Development of MODS in severely burned patients is highly fatal. The present study was conducted to elucidate the etiology and quantify the Multiple Organ Dysfunction (MODS) in major burn patients. Multiple organ dysfunctions in major burnt patients was a prospective analytic study. A total of thirty patients were included in the study, which was conducted in the Burn and Plastic Surgery unit, Bir Hospital, Kathmondu, Nepal over the period of eighteen months from January 2002 to June 2003. Patients with acute major burn i.e. 24 hours f

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Golomidov, A. V., E. V. Grigoriev, V. G. Moses, and K. B. Moses. "Multiple organ dysfunction syndrome prediction in newborn children." Innovative Medicine of Kuban, no. 1 (March 30, 2022): 83–89. http://dx.doi.org/10.35401/2500-0268-2022-25-1-83-89.

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There are several directions for predicting multiple organ dysfunction syndrome (MODS), but almost all of them are poorly tested in neonatology. This review is presented to indicate the problem of the condition severity objectification of newborns and the possibility of predicting the development of MODS. Scales for assessing the severity of MODS in critically ill children have been developed and used since the end of the last century, but their validation in the newborns faces certain difficulties. Prognostic nosospecific scales: NICHD (National Institute of Child Health and Human Development

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Akhila, Anil1 Anjitha Santhosh1 Manju Thampi2 Shaiju. S. Dharan3 Drishya L.4*. "TROPIC FEVER WITH MULTIPLR ORGAN DYSFUNCTION SYNDROME : A CASE REPORT." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 1207–10. https://doi.org/10.5281/zenodo.11080552.

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Tropic  fever with multiple organ dysfunction is often seen as undifferentiated fevers with organ failure. Dengue, scrub typhus, leptospirosis, malaria, typhoid fever and some other fevers are incorporated in Tropic fever. These fevers are prevalent in tropical and subtropical regions. Symptoms of tropic fever includes sudden onset of fever, headache, chills, myalgia, transient skin rashes, conjunctival suffusion. A variety of acute insults, including sepsis, can cause progressive and potentially reversible physiologic dysfunction in two or organs or organ systems which is what is known a

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Royston, Rachel. "Multiple organ dysfunction syndrome: an extended patient care report." Veterinary Nurse 12, no. 2 (2021): 85–91. http://dx.doi.org/10.12968/vetn.2021.12.2.85.

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This report describes and reflects on the intensive nursing care provided to a patient with multiple organ dysfunction syndrome (MODS) and systemic inflammatory response syndrome (SIRS). Veterinary nurses are at the forefront of supportive care for these critical patients and nursing interventions should focus on close and frequent monitoring for early detection of sepsis. An understanding of the physiological processes that occur with these diseases can increase awareness of the potential life-threatening complications associated with MODS, thus, allowing early recognition and intervention to

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Baue, Arthur E., Rodney Durham, and Eugen Faist. "SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS), MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS), MULTIPLE ORGAN FAILURE (MOF)." shock 10, no. 2 (1998): 79–89. http://dx.doi.org/10.1097/00024382-199808000-00001.

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Halim, Hendy, Ida Bagus Gede Suparyatha, I. Made Arimbawa, and I. Nyoman Budi Hartawan. "Multiple organ dysfunction syndrome associated with hyperglycemia in children requiring intensive care." Paediatrica Indonesiana 55, no. 4 (2015): 230. http://dx.doi.org/10.14238/pi55.4.2015.230-4.

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Background Hyperglycemia can be caused by three or more organ dysfunctions and occurs in children requiring intensive care in the first 48 hours. Blood sugar level higher than 140 mg/dl is considered as hyperglycemia in children requiring intensive care.Objective To determine the association between multiple organ dysfunction syndrome (MODS) in children requiring intensive care and hyperglycemia with blood sugar level higher than 140 mg/dl.Methods This case control study without matching was conducted on children aged 1 month-12 years from pediatric ward at Sanglah hospital during June-August

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Whitmore, Laura C., Kelli L. Goss, Elizabeth A. Newell, Brieanna M. Hilkin, Jessica S. Hook, and Jessica G. Moreland. "NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome." American Journal of Physiology-Lung Cellular and Molecular Physiology 307, no. 1 (2014): L71—L82. http://dx.doi.org/10.1152/ajplung.00054.2014.

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Systemic inflammatory response syndrome (SIRS) is a common clinical condition in patients in intensive care units that can lead to complications, including multiple organ dysfunction syndrome (MODS). MODS carries a high mortality rate, and it is unclear why some patients resolve SIRS, whereas others develop MODS. Although oxidant stress has been implicated in the development of MODS, several recent studies have demonstrated a requirement for NADPH oxidase 2 (NOX2)-derived oxidants in limiting inflammation. We recently demonstrated that NOX2 protects against lung injury and mortality in a murin

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HYDO, LYNN J., and Philip S. Barie. "PATTERNS OF MORTALITY FROM MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS." Critical Care Medicine 33 (December 2005): A77. http://dx.doi.org/10.1097/00003246-200512002-00276.

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Curran, Carol A. "Multiple Organ Dysfunction Syndrome (MODS) in the Obstetric Population." Journal of Perinatal & Neonatal Nursing 15, no. 4 (2002): 37–55. http://dx.doi.org/10.1097/00005237-200203000-00006.

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Çetinkaya, Merih, Nilgün Köksal, and Hilal Özkan. "A New Scoring System For Evaluation of Multiple Organ Dysfunction Syndrome in Premature Infants." American Journal of Critical Care 21, no. 5 (2012): 328–37. http://dx.doi.org/10.4037/ajcc2012312.

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Background The Neonatal Multiple Organ Dysfunction (NEO-MOD) scoring system is used to predict mortality in infants with multiple organ dysfunction syndrome (MODS). The NEOMOD scoring system was extended to include involvement of the microvascular system. This modified scoring system was developed to enable more accurate and earlier diagnosis of MODS in premature infants. Objective To evaluate the modified NEOMOD scoring system in preterm infants with MODS and compare its effectiveness with the NEOMOD scoring system. Methods This prospective study was performed in a tertiary neonatal intensive

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Novak, Tanya, Jeremy Chase Crawford, Christoph Lange, Georg Hahn, and Adrienne G. Randolph. "Genes associated with Multiple Organ Dysfunction Syndrome during severe pediatric influenza." Journal of Immunology 208, no. 1_Supplement (2022): 161.01. http://dx.doi.org/10.4049/jimmunol.208.supp.161.01.

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Abstract Influenza remains a global pathogen that causes significant morbidity and mortality even in previously healthy children. Multiple Organ Dysfunction Syndrome (MODS) is a potential complication developed during severe infection. This multi-site, national study investigated which genes are associated with resolving, developing, or predicting prolonged MODS in children admitted to ICU with severe influenza. PAXgene whole blood RNA from 216 influenza positive patients (median age 6.7 years, IQR: 2.6, 11.2) was extracted and hybridized to 469 NanoString nCounter® mRNA probes including posit

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Golomidov, A. V., O. G. Kryuchkova, E. V. Grigoriev, et al. "Epidemiological features of multiple organ dysfunction syndrome in newborns in the Kemerovo region – Kuzbass." Messenger of ANESTHESIOLOGY AND RESUSCITATION 21, no. 4 (2024): 78–84. http://dx.doi.org/10.24884/2078-5658-2024-21-4-78-84.

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Introduction. Theoretical and practical issues of the short-term and long-term prediction of the onset of multiple organ dysfunction syndrome (MODS) and its outcomes in newborns is a promising area of neonatology, since it allows a doctor to be warned about an impending catastrophe, and opens a «window of opportunity» for timely correction of treatment tactics and prevention of complications.The objective was to study the epidemiological features and medical consequences of multiple organ dysfunction syndrome in full-term and premature newborns born in critical condition.Materials and methods.

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Nikitsina, K. V., and G. V. Ilukevich. "MULTIPLE ORGAN DYSFUNCTION SYNDROME IN ACUTE NECROTIZING PANCREATITIS." Novosti Khirurgii 29, no. 5 (2021): 598–606. http://dx.doi.org/10.18484/2305-0047.2021.5.598.

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Acute necrotizing pancreatitis (ANP) is associated with significantlyhighermorbidity and mortality. It is still difficult for the surgeon to choose and schedule the most appropriate treatment.In the early phase of the disease, surgical activity is considered to be ineffective and is associated with high risks. The only chance to save the patient is to conduct the intensive therapy in the intensive care unit, based on current pathogenetic approaches. The present review analyzed the current understanding of the pathogenesis of multiple organ dysfunction syndrome (MODS) in acute necrotizing pancr

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Xiao, Kun, Bin Liu, Wei Guan, et al. "Prognostic Analysis of Elderly Patients with Multiple Organ Dysfunction Syndrome Undergoing Invasive Mechanical Ventilation." Journal of Healthcare Engineering 2020 (March 19, 2020): 1–7. http://dx.doi.org/10.1155/2020/6432048.

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Objective. To prospectively investigate early prognostic assessments of patients with Multiple Organ Dysfunction Syndrome in the Elderly (MODSE) who were receiving invasive mechanical ventilation (IMV). Methods. The clinical data of 351 patients were enrolled prospectively between January 2013 and January 2018. The Acute Physiology and Chronic Health Evaluation II (APACHE II), APACHE III, Simplified Acute Physiology Score (SAPS II), and Multiple Organ Dysfunction Score (MODS) were calculated. According to the outcome of 28-day, the patients were divided into survivors and nonsurvivors. Additio

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Khutornya, M. V., A. V. Ponasenko, A. V. Tsepokina, et al. "Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and polymorphic variants of TREM-1 in the development of multiple organ dysfunction syndrome after coronary artery bypass grafting." General Reanimatology 15, no. 3 (2019): 48–60. http://dx.doi.org/10.15360/1813-9779-2019-3-48-60.

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The onset of critical complications (multiple organ dysfunction syndrome, MODS) after coronary artery bypass grafting is the result of severe stress response. The key etiopathological factor of the induction phase of the complex pathological process, which ultimately leads to dysfunction of organs and systems, is the dysfunction of the immune response. The characteristics of reactions of the immune system in a particular individual are genetically determined and realized through innate immunity activation. Aim. To determine the role of TREM-1 gene polymorphism through the changes of sTREM seru

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Ronco, Claudio, Zaccaria Ricci, and Faeq Husain-Syed. "From Multiple Organ Support Therapy to Extracorporeal Organ Support in Critically Ill Patients." Blood Purification 48, no. 2 (2019): 99–105. http://dx.doi.org/10.1159/000490694.

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Critically ill patients developing severe forms multiple organ dysfunction syndrome (MODS) may not be adequately supported by pharmacologic management. In these complex cases, a single form of extracorporeal organ support (ECOS) may be required, but multiple organ support therapy (MOST) is currently seen as a feasible approach. Severe renal dysfunction is a typical syndrome requiring renal replacement therapy (RRT) in the context of MODS. After more than a decade of RRT application in various intensive care settings, ECOS are not anymore seen as extraordinary or particularly aggressive techniq

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Bordeanu-Diaconescu, Eliza M., Andreea Grosu-Bularda, Adrian Frunza, et al. "Comprehensive Review and Update on Multiple Organ Dysfunction Syndrome in Burn Patients: Pathophysiology, Risk Factors, and Management Strategies." Romanian Journal of Military Medicine 127, no. 6 (2024): 480–90. https://doi.org/10.55453/rjmm.2024.127.6.8.

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Burn injuries are among the most severe forms of trauma, often leading to multiple organ dysfunction syndrome (MODS), a major contributor to morbidity and mortality in burn patients. This review examines the pathophysiological mechanisms, clinical manifestations, and management strategies associated with MODS in burn patients. Following a severe burn injury, the systemic inflammatory response and subsequent release of pro-inflammatory cytokines precipitate dysfunction across various organ systems. Early recognition and aggressive management of MODS, including fluid resuscitation, infection con

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El-Menyar, Ayman, Hassan Al Thani, El Rasheid Zakaria, et al. "Multiple Organ Dysfunction Syndrome (MODS): Is It Preventable or Inevitable?" International Journal of Clinical Medicine 03, no. 07 (2012): 722–30. http://dx.doi.org/10.4236/ijcm.2012.37a127.

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Li, Li, Jilun Pan, and Yaoting Yu. "Development of sorbent therapy for multiple organ dysfunction syndrome (MODS)." Biomedical Materials 2, no. 2 (2007): R12—R16. http://dx.doi.org/10.1088/1748-6041/2/2/r02.

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Thadani, Sameer, Dana Fuhrman, Claire Hanson, et al. "Patterns of Multiple Organ Dysfunction and Renal Recovery in Critically Ill Children and Young Adults Receiving Continuous Renal Replacement Therapy." Critical Care Explorations 6, no. 5 (2024): e1084. http://dx.doi.org/10.1097/cce.0000000000001084.

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OBJECTIVES: Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to describe the pattern and impact of organ dysfunction on renal outcomes in critically ill children and young adults with AKI-D. DESIGN: Retrospective cohort. SETTING: Two large quarternary care pediatric hospitals. PATIENTS: Patients 26 y old or younger who received CRRT from 2014 to 2020, excluding

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Sablotzki, Armin, Ivar Friedrich, Jörg Mühling, et al. "The systemic inflammatory response syndrome following cardiac surgery: different expression of proinflammatory cytokines and procalcitonin in patients with and without multiorgan dysfunctions." Perfusion 17, no. 2 (2002): 103–9. http://dx.doi.org/10.1191/0267659102pf543oa.

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Cardiopulmonary bypass is associated with an injury that may cause pathophysiological changes in the form of systemic inflammatory response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS). In the present study, we investigated the inflammatory response of patients with multiple organ dysfunctions following open-heart surgery. Plasma levels of cytokines (IL-1β, IL-6, IL-8, IL-18) and procalcitonin (PCT) were measured on the first four postoperative days in 12 adult male patients with SIRS and two or more organ dysfunctions after myocar-dial revascularization (MODS group), and 15 p

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Zhang, Yiwen, Yanbo Feng, Wenshuai Wang, Le Jia, and Jianjun Zhang. "Characterization and Hepatoprotections of Ganoderma lucidum Polysaccharides against Multiple Organ Dysfunction Syndrome in Mice." Oxidative Medicine and Cellular Longevity 2021 (February 3, 2021): 1–13. http://dx.doi.org/10.1155/2021/9703682.

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Background. The liver is one of the most commonly affected organs in multiple organ dysfunction syndrome (MODS). In recent years, there have been many studies on Ganoderma lucidum polysaccharides (GLP), but the role of GLP in MODS is still unclear. The purpose of this work was to explore the antioxidant, anti-inflammatory, and protective effects of GLP on the liver in MODS model mice. Methods. The characteristic properties of GLP were processed by physicochemical analysis. The MODS models were successfully established with intraperitoneal injection of zymosan in Kunming strain mice. The antiox

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Xiong, Wei, Jun Ouyang, Hai Ci, et al. "The predictive value of serum neopterin for multiple organ dysfunction syndrome in severe burn patients." Pteridines 29, no. 1 (2018): 196–200. http://dx.doi.org/10.1515/pteridines-2018-0019.

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AbstractObjective To investigate the predictive value of serum neopterin for multiple organ dysfunction syndrome (MODS) in severe burn patients. Methods Seventy-six severe burn patients with burns covering a total body surface area (TBSA) above 70% were included in this study. Of the 76 patients, 29 cases developed MODS (MODS group) and the remaining 47 subjects did not (non-MODS group). From the MODS group, 12 patients died (Death group) and 17 patients survived (Survive group). The serum level of neopterin in the MODS and non-MODS groups were examined by radioimmunoassay on following 1, 3 ,

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Tachyla, S. A., V. A. Dudko, A. V. Marochkov, A. A. Bondarenko, and V. A. Livinskaya. "MONITORING OF CENTRAL HEMODYNAMICS IN PATIENTS WITH MULTIPLE ORGAN DYSFUNCTION SYNDROME." Journal of the Grodno State Medical University 19, no. 2 (2021): 187–93. http://dx.doi.org/10.25298/2221-8785-2021-19-2-187-193.

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Objective: comparative analysis of the use of PiCCO monitoring for correction of the intensive care in patients with multiple organ dysfunction syndrome (MODS) after abdominal and cardiac surgery. Material and methods. A prospective cohort study was carried out in 19 patients with MODS after abdominal (n=10) and cardiac (n=9) interventions. Of these, 13 men and 6 women, aged 63 (58-69) years, their height was 176 (174-180) cm, body weight - 90 (80-100) kg. Central hemodynamic parameters were monitored in these patients by the PiCCO method. Several steps have been distinguished in the study: 1s

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Tochilo, S. A., and Yu G. Nikiforova. "EXPERIENCE OF TARGETED ANTIBACTERIAL THERAPY IN A PATIENT WITH MULTIPLE ORGAN DYSFUNCTION SYNDROME." Health and Ecology Issues, no. 2 (June 28, 2018): 103–9. http://dx.doi.org/10.51523/2708-6011.2018-15-2-21.

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Objective : to analyze our own experience and literature data on the use of targeted antibacterial therapy in a patient with severe pneumonia and multiple organ dysfunction syndrome (MODS). Materials. The work presents a clinical case of successful treatment of a patient with community-acquired pneumonia, sepsis, and MODS, caused by multidrug resistant pathogens. Targeted antibiotic therapy was used during the treatment of the patient. Discussion . We have done a review of the literature and our own data on the antibiotic therapy for community-acquired pneumonia. The targeted antibacterial the

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Surbatovic, Maja, Sonja Radakovic, Krsta Jovanovic, and Predrag Romic. "New strategies in multiple organ dysfunction syndrometherapy for sepsis." Srpski arhiv za celokupno lekarstvo 133, no. 7-8 (2005): 379–83. http://dx.doi.org/10.2298/sarh0508379s.

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Despite more than 20 years of extensive research, sepsis and/or trauma induced multiple organ dysfunction syndrome (MODS) remain the chief cause of death in intensive care units, with mortality rates between 30% and 80%. Early goal-directed therapy (EGDT), use of drotrecogin alfa (activated), tight control of hyperglycaemia, and adrenal replacement therapy (low doses of corticosteroids)all constitute new treatment strategies. In future, a combination of therapies should be individually adjusted for each patient.

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Ionescu (Miron), Andreea-Iuliana, Dimitrie-Ionut Atasiei, Radu-Tudor Ionescu, et al. "Prediction of Subclinical and Clinical Multiple Organ Failure Dysfunction in Breast Cancer Patients—A Review Using AI Tools." Cancers 16, no. 2 (2024): 381. http://dx.doi.org/10.3390/cancers16020381.

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This review explores the interconnection between precursor lesions of breast cancer (typical ductal hyperplasia, atypical ductal/lobular hyperplasia) and the subclinical of multiple organ failure syndrome, both representing early stages marked by alterations preceding clinical symptoms, undetectable through conventional diagnostic methods. Addressing the question “Why patients with breast cancer exhibit a tendency to deteriorate”, this study investigates the biological progression from a subclinical multiple organ failure syndrome, characterized by insidious but indisputable lesions, to an acu

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Rendy, Leo, Heber B. Sapan, and Laurens T. B. Kalesaran. "Multiple organ dysfunction syndrome (MODS) prediction score in multi-trauma patients." International Journal of Surgery Open 8 (2017): 1–6. http://dx.doi.org/10.1016/j.ijso.2017.05.003.

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Osipenko, A. N., S. A. Tachyla, and A. V. Marochkov. "Features of lipid metabolism in multiple organ dysfunction syndrome: causes and consequences of the resulting metabolic changes." Health and Ecology Issues 21, no. 3 (2024): 7–16. http://dx.doi.org/10.51523/2708-6011.2024-21-3-01.

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The review presents data from various researchers, including the authors of this article, regarding the role of lipid metabolism disorders, as well as the causes that caused them in the formation of multiple organ dysfunction syndrome (MODS). Information is provided on the contribution of intense lipolysis in fat depots to the development of the immune response, as well as the formation of acute respiratory distress syndrome and acute kidney injury. The contribution of intense lipolysis to the process of changing the composition of fatty acids in blood plasma is characterized. The importance o

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Marijayanth, Manthappa, Ashok Horatti, Varsha Tandure, and Suheil Dhanse. "Clinical Profile and Outcome of Multiple Organ Dysfunction Syndrome (MODS) in a Tertiary Care Centre of Manipal, Karnataka." Journal of Evidence Based Medicine and Healthcare 8, no. 41 (2021): 3547–52. http://dx.doi.org/10.18410/jebmh/2021/643.

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BACKGROUND To study the clinical profile and outcome of multiple organ dysfunction syndrome (MODS) in previously healthy adult patients and to assess the correlation between sequential organ failure assessment (SOFA) score at admission and mortality in these patients. METHODS This study was conducted at a tertiary care hospital attached to a medical college of south India. This was a prospective observational study. All adult patients presenting with multiple organ dysfunction syndrome between October 2010 and June 2012 were selected for the study. SOFA score was recorded for all the patients

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Grigoryev, E. V., D. L. Shukevich, V. G. Matveeva, and R. A. Kornelyuk. "IMMUNOSUPPRESSION AS A COMPONENT OF MULTIPLE ORGAN DYSFUNCTION SYNDROME FOLLOWING CARDIAC SURGERY." Complex Issues of Cardiovascular Diseases 7, no. 4 (2018): 84–91. http://dx.doi.org/10.17802/2306-1278-2018-7-4-84-91.

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Aim. To defne the role of myeloid-derived suppressor cells in the development of persistent multiple organ dysfunction followed cardiac surgeries with cardiopulmonary bypass.Methods. 40 patients who have undergone cardiac surgery were included in the study. Granulocyte myeloid-derived suppressor cells (G-MDSC) were defned as cells with the HLA-DR– / CD11β+ / CD15+ / CD33+ phenotype, and monocytic MDSC (M-MDSC) as cells with the HLA-DR– / CD11β+ / CD14+ / CD33+ phenotype using ﬂow cytometry. Levels of cytokines, IL-1β, IL-6, TNF-α, and IL-10 were measured with an enzyme immunoassay. All patient

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Zheng, Dan, Guo-Liang Yu, Yi-Ping Zhou, Qiao-Min Zhang, Chun-Guo Wang, and Sheng Zhang. "Association between lactic acidosis and multiple organ dysfunction syndrome after cardiopulmonary bypass." PeerJ 12 (January 31, 2024): e16769. http://dx.doi.org/10.7717/peerj.16769.

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Background The relationship between hyperlactatemia and prognosis after cardiopulmonary bypass (CPB) is controversial, and some studies ignore the presence of lactic acidosis in patients with severe hyperlactacemia. This study explored the association between lactic acidosis (LA) and the occurrence of multiple organ dysfunction syndrome (MODS) after cardiopulmonary bypass. Methods This study was a post hoc analysis of patients who underwent cardiac surgery between February 2017 and August 2018 and participated in a prospective study at Taizhou Hospital. The data were collected at: ICU admissio

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Xiao, Kun, Longxiang Su, Bingchao Han, et al. "Prognosis and weaning of elderly multiple organ dysfunction syndrome patients with invasive mechanical ventilation." Chinese Medical Journal 127, no. 1 (2014): 11–17. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20131468.

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Background Elderly multiple organ dysfunction syndrome (MODS) patients receiving invasive mechanical ventilation have poor prognosis in intensive care units (ICUs). We studied the usefulness of four commonly used severity scores and extrapulmonary factors that affected weaning to predict outcome of such patients. Methods Clinical data of 197 patients on admission to ICUs (from January 2009 to June 2012) were used retrospectively. The Acute Physiology and Chronic Health Evaluation (APACHE) II, APACHE III, Sample Acute Physiological Score (SAPS) II and MODS scores were calculated. All the patien

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Fry, Donald E. "Article Commentary: Sepsis, Systemic Inflammatory Response, and Multiple Organ Dysfunction: The Mystery Continues." American Surgeon 78, no. 1 (2012): 1–8. http://dx.doi.org/10.1177/000313481207800102.

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Human sepsis is thought to be systemic inflammatory response syndrome (SIRS) that is activated by invasive infection. The multiple organ dysfunction syndrome (MODS) is the identified failure of critical organ function in patients that have sustained SIRS. Because SIRS and MODS are consequences of the excessive activation of inflammation, extensive research and numerous clinical trials have pursued treatments that would modify the inflammatory response. This presentation reviews the normal local mechanisms of inflammation and provides a theoretical framework for the transition of the inflammato

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Tachyla, S. A., A. V. Marochkov, and V. A. Livinskaya. "Screening Criteria for Multiple Organ Dysfunction after Abdominal Surgery (Clinical Research)." General Reanimatology 15, no. 3 (2019): 61–72. http://dx.doi.org/10.15360/1813-9779-2019-3-61-72.

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Objective: to determine the feasibility of using C-reactive protein (CRP) and cholesterol levels as biochemical screening markers for multiple organ dysfunction syndrome (MODS) in patients after abdominal surgery.Materials and methods. A prospective case-control study was performed in 192 patients who receivedtreatment at the Intensive Care Unit (ICU) after abdominal surgery. Patients were classified into two groups: Group 1 (n=95) of patients without MODS and Group 2 (n=97) of patients with MODS. The signs of MODS were identified based on 2001 SCCM/ACCP consensus conference criteria. During t

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Duchnowski, Piotr. "The Role of the N-Terminal of the Prohormone Brain Natriuretic Peptide in Predicting Postoperative Multiple Organ Dysfunction Syndrome." Journal of Clinical Medicine 11, no. 23 (2022): 7217. http://dx.doi.org/10.3390/jcm11237217.

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Background: Multiple organ dysfunction syndrome (MODS) is the progressive and potentially reversible dysfunction of at least two organ systems in the course of an acute and life-threatening disorder of systemic homeostasis. MODS is a serious post-cardiac-surgery complication in valvular heart disease that is associated with a high risk of death. This study assessed the predictive ability of selected preoperative and perioperative parameters for the occurrence of MODS in the early postoperative period in a group of patients with severe valvular heart disease. Methods: Subsequent patients with s

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Lee, Sungho, Hyunsoo Hwang, Jose-Miguel Yamal, et al. "IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury." Journal of Neurosurgery 131, no. 6 (2019): 1931–37. http://dx.doi.org/10.3171/2018.8.jns18676.

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OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS.METHODSThe authors performed a secondary analysis of a recent randomized clinical trial studying the effects of erythropoietin and blood transfusion threshold on neurological recovery after TBI. Admission clinical, demographic, laboratory, and imaging parameters were used in a multivariable Cox regression an

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Zhou, Jie, Shunjin Fang, Jianfeng Zhu, Yao Su, and Huifei Zhou. "Multiple Organ Dysfunction Syndrome Associated With Pneumonia: A Retrospective Study With a Focus on Respiratory Failure." British Journal of Hospital Medicine 86, no. 5 (2025): 1–13. https://doi.org/10.12968/hmed.2024.0851.

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Aims/Background Pneumonia is a complex condition with rapid progression, often leading to multiple organ dysfunction syndrome (MODS), which significantly impacts patient quality of life and prognosis. This study aims to identify risk factors closely associated with the development of MODS by conducting a retrospective analysis of clinical data from 150 patients with pneumonia, providing insights for informing the prevention and treatment of pneumonia. Methods We recruited 150 patients with pneumonia admitted to Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University betwe

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Golomidov, A. V., O. G. Kryuchkova, E. V. Grigoriev, V. G. Moses, and K. B. Moses. "The effectiveness of levosimendan in newborns with low cardiac output syndrome in the multiple organ dysfunction." Messenger of ANESTHESIOLOGY AND RESUSCITATION 22, no. 3 (2025): 55–61. https://doi.org/10.24884/2078-5658-2025-22-3-55-61.

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Introduction. The combination of multiple organ dysfunction syndrome and low cardiac output syndrome (MODS + LCOS) is an unfavorable phenotype of a critical condition with a high risk of death, in which standard cardiotonic therapy is not always effective.The objective was to evaluate the effectiveness of levosimendan in the treatment of small cardiac output syndrome in newborns with multiple organ dysfunction syndrome. Materials and methods. 68 newborns with MODS+ LCOS were studied using the continuous method. All the studied children were on artificial lung ventilation, received inotropic th

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Mohamed, Abdelrahman Hussain *. Aisha Yahya Saddeek Abdurrahman Abdullah Alshehri Mohammed Ali Ahmed Alshehri Hanouf abdullah alhussini Muhannad Awadh Alharthi Ali hussain alnujaydi Ahmed Kamel Alabdrab Ali Abdullah Mohammed M. ALGarni Sultan Ahmed Almallki Abdullah Saeed ALGhamdi Dina Mohsen Al khafaji. "MULTIPLE ORGAN FAILURE IN PATIENTS IN THE INTENSIVE CARE UNIT." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 701–5. https://doi.org/10.5281/zenodo.2536226.

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<strong><em>Introduction:</em></strong><em> Sepsis and multiple organ dysfunction syndrome (MODS) are considered clinical scenarios that most commonly seen in the critically ill patients in surgical settings. Developments in medicine have led to elder population, and have let critically ill and injured patients to survive, only to develop sepsis afterwards. It is estimated one million cases of sepsis in the US every year.</em> <em>Sepsis as a separate clinical entity was first described by Bone and coworkers in 1989, and can be recognized as the invasion of microorganisms and/or their toxins i

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Bednarz-Misa, Iwona, Magdalena Mierzchala-Pasierb, Patrycja Lesnik, et al. "Cardiovascular Insufficiency, Abdominal Sepsis, and Patients’ Age Are Associated with Decreased Paraoxonase-1 (PON1) Activity in Critically Ill Patients with Multiple Organ Dysfunction Syndrome (MODS)." Disease Markers 2019 (February 11, 2019): 1–12. http://dx.doi.org/10.1155/2019/1314623.

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Oxidative stress and uncontrolled inflammation are hallmarks of sepsis, leading to organ failure and death. As demonstrated in animal studies, oxidative stress can be alleviated by antioxidant therapies. Paraoxonase-1 (PON1) is a serum-based antioxidant, anti-inflammatory agent, detoxifier, and quorum-sensing factor found to be a prognostic marker in sepsis. However, its associations with multiple organ dysfunction syndrome (MODS), a complication of sepsis and the leading cause of death in the surgical intensive care units (ICU), as well as with specific organ dysfunction, infection site, and

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Bowen, Fan, Klatt Juliane, Moor Michael, et al. "Prediction of recovery from multiple organ dysfunction syndrome in pediatric sepsis patients." Bioinformatics 38, Supplement_1 (2022): i101—i108. https://doi.org/10.1093/bioinformatics/btac229.

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Sepsis is a leading cause of death and disability in children globally, accounting for 3 million childhood deaths per year. In pediatric sepsis patients, the multiple organ dysfunction syndrome (MODS) is considered a significant risk factor for adverse clinical outcomes characterized by high mortality and morbidity in the pediatric intensive care unit. The recent rapidly growing availability of electronic health records (EHRs) has allowed researchers to vastly develop data-driven approaches like machine learning in healthcare and achieved great successes. In this work, we develope a machine le

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Ertel, W., H. Friedl, and O. Trentz. "Multiple Organ Dysfunction Syndrome (MODS) Following Multiple Trauma: Rationale and Concept of Therapeutic Approach." European Journal of Pediatric Surgery 4, no. 04 (1994): 243–48. http://dx.doi.org/10.1055/s-2008-1066112.

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Abrams, Simon T., Lijun Wang, Jun Yong, et al. "The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction." Biomedicines 10, no. 12 (2022): 3256. http://dx.doi.org/10.3390/biomedicines10123256.

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Background: Multiple organ injury and dysfunction often occurs in acute critical illness and adversely affects survival. However, in patients who survive, organ function usually recovers without permanent damage. It is, therefore, likely that there are reversible mechanisms, but this is poorly understood in the pathogenesis of multiple organ dysfunction syndrome (MODS). Aims: Based on our knowledge of extracellular histones and pneumolysin, as endogenous and exogenous pore-forming toxins, respectively, here we clarify if the extent of cell membrane disruption and recovery is important in MODS.

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Zhang, Mingjun, Longjin Chen, Kai Chi, Liyan Xu, and Yonglin Li. "Necrotizing fasciitis complicated with multiple organ dysfunction syndrome after breast augmentation with fat from the waist and lower extremities: a case report." Journal of International Medical Research 48, no. 7 (2020): 030006052093762. http://dx.doi.org/10.1177/0300060520937623.

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Necrotizing fasciitis (NF) is a rapidly progressing soft tissue infection with a mortality rate as high as 30% to 50%. However, the incidence rate of NF after liposuction is extremely low. In the current case report, we describe a woman with NF who developed multiple organ dysfunction syndrome (MODS) after fat acquisition. The aim of this paper is to summarize the management of these patients. After debridement and drainage, correction of multiple organ failure, and plastic surgery, the patient’s organ and lower limb functions improved to a normal level. Early diagnosis, early operative treatm

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Yang, Runkuan, Jyrki Tenhunen, and Tor Inge Tonnessen. "HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis." International Journal of Inflammation 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/1817564.

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Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extrapancreatic organs dysfunction; however, the underlying mechanisms are still not clear. Ischemia-reperfusion, circulating inflammatory cytokines, and possible bile cytokines significantly contribute to gut mucosal injury and intestinal bacterial translocation (BT) during SAP. Circulating HMGB1 level is significantly increased in SAP patients and HMGB1 is an important factor that mediates (at least partly) gut BT during SAP. Gut BT plays a critical role in triggering/

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Manterola, Carlos. "SRIS and SDOM Constructs Associated with Sepsis." International Journal of Medical and Surgical Sciences 3, no. 4 (2018): 997–1002. http://dx.doi.org/10.32457/ijmss.2016.035.

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Sepsis is a systemic inflammatory response syndrome (SIRS) that is triggered by infection. On the other hand, multiple organ dysfunction syndrome (MODS) is the failure of critical organ function in patients suffering from SIRS. Because SIRS and SDOM are consequences of excessive inflammatory activation. The aim of this article is to provide a review of some pathophysiological aspects of the SRIS / SDOM construct of infectious origin, using the acute cholangitis as an example of this chain of events.

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