Log in

Relevant bibliographies by topics / Multiple primary cancers

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers
Reports

Academic literature on the topic 'Multiple primary cancers'

Author: Grafiati

Published: 20 February 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Multiple primary cancers.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Multiple primary cancers"

1

Lee, K., H. Jang, M. Choi, et al. "Clinical analysis of multiple primary cancers." Journal of Clinical Oncology 25, no. 18_suppl (2007): 19639. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.19639.

Full text

Abstract:

19639 Background: Multiple primary cancers are defined as two or more abnormal growths of tissue occurring simultaneously or abnormal growths of tissues that follow a previous neoplasm but are not metastases of the latter in the same individual. The primary objective of this study was to determine the occurrence, clinical characteristics and prognosis of multiple primary cancers in single institution, respectively. Methods: Between January 1995 and June 2006, patients with multiple primary cancers were selected from a review of patients who had been treated and followed-up in our Ewha Womans University Hospital. Demographic data were obtained from medical records. Results: Two hundred seven patients were selected and patients with multiple primary cancers constituted 1.95% of all malignancies. Male to female ratio was 1.84. (male 134 vs. female 73 patients) The median age first cancer diagnosis was 67 years old in male, 57 in female. The incidence of synchronous cancers is higher than metachronous. (108 vs. 99) and the median time to additional cancers in metachronous group was 35 months. The most frequent cancers was gastrointestinal cancers in both sex synchronously and metachronously. In male, colorectal cancer followed by gastric cancer methchronously (9.1%), genitourinary cancer with another genitourinary cancer synchronously (12.7%) were frequently observed. In female, breast cancer followed by colorectal cancer metachronously (6.8%), gastric cancer with colorectal cancer (6.9%) were frequently observed. The median survival duration was 14.4 months totally from the index diagnosis and synchronous cancers showed lower survival duration than metachronous cancers. (7.4 vs. 26.1 months, p=0.017) Conclusions: Adequate investigations including G-I tract should focus in the first 3 years after initial diagnosis to detect second primary cancers earlier. No significant financial relationships to disclose.

APA, Harvard, Vancouver, ISO, and other styles

2

Kim, Soo Hong, Hyung Jin Kim, Jae Im Lee, et al. "Multiple Primary Cancers Including Colorectal Cancer." Journal of the Korean Society of Coloproctology 24, no. 6 (2008): 467. http://dx.doi.org/10.3393/jksc.2008.24.6.467.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Fabian, Thomas. "Multiple primary lung cancers." Journal of Thoracic Disease 10, S26 (2018): S3109—S3110. http://dx.doi.org/10.21037/jtd.2018.08.02.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Verhagen, A. F. T., G. Tavilla, H. J. C. van de Wal, A. Cox, and L. K. M. Lacquet. "Multiple Primary Lung Cancers." Thoracic and Cardiovascular Surgeon 42, no. 01 (1994): 40–44. http://dx.doi.org/10.1055/s-2007-1016453.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Kono, Michio, Masahiko Fujii, Shuji Adachi, Koji Tanaka, Tadafumi Shimizu, and Shozo Hirota. "Multiple primary lung cancers." Journal of Thoracic Imaging 8, no. 1 (1993): 63–68. http://dx.doi.org/10.1097/00005382-199320000-00008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Kono, Michio, Masahiko Fujii, Shuji Adachi, Koji Tanaka, Tadafumi Shimizu, and Shozo Hirota. "Multiple primary lung cancers." Journal of Thoracic Imaging 8, no. 1 (1993): 63–68. http://dx.doi.org/10.1097/00005382-199324000-00008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Deschamps, Claude, Peter C. Pairolero, Victor F. Trastek, and W. Spencer Payne. "Multiple primary lung cancers." Journal of Thoracic and Cardiovascular Surgery 99, no. 5 (1990): 769–78. http://dx.doi.org/10.1016/s0022-5223(19)36891-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Shigematsu, Hisao, Keiichi Hosokawa, Masaaki Kaburagi, Akio Tanaka, Kaoru Kusama, and Hideaki Sakashita. "Multiple Primary Oral Cancers." Asian Journal of Oral and Maxillofacial Surgery 20, no. 2 (2008): 74–80. http://dx.doi.org/10.1016/s0915-6992(08)80014-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Wu, Song-chang, Zhen-Qiong Lin, Chang-Wen Xu, Kai-shi Koo, Ou-Ling Huang, and Ding-Quan Xie. "Multiple Primary Lung Cancers." Chest 92, no. 5 (1987): 892–96. http://dx.doi.org/10.1378/chest.92.5.892.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

RIBET, M., and P. DAMBRON. "Multiple primary lung cancers." European Journal of Cardio-Thoracic Surgery 9, no. 5 (1995): 231–36. http://dx.doi.org/10.1016/s1010-7940(05)80155-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic "Multiple primary cancers"

1

Soerjomataram, Isabelle. "Multiple primary cancers in patients with breast ans skin cancer." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10779.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Probert, Adam. "The genetic epidemiology of multiple primary breast and ovarian cancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0024/MQ50860.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Probert, Adam. "The genetic epidemiology of multiple primary breast and ovarian cancer /." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20971.

Full text

Abstract:

Breast and ovarian cancers are among the most common tumours affecting Canadian women. A proportion of these tumours was thought to be due to family history and the breast cancer susceptibility gene and are more likely to occur before the age of 50. It is hypothesized that women who have both primary tumours of the breast and ovary are more likely to have a mutation in this gene. The main objective of this study is to examine the role of family history in those women with breast cancer that subsequently develop ovarian cancer. The role of chemotherapy and radiotherapy in the treatment of breast cancer, as a risk factor for future development of ovarian cancer, was also assessed.<br>This was a case-control study. The cases studied were women with multiple primary breast and ovarian cancers and were identified from the Quebec Tumour Registry and a database at Sunnybrook Hospital in Toronto.

APA, Harvard, Vancouver, ISO, and other styles

4

Maharaj, Lenushka. "Use of in vitro primary culture models to investigate the activity of standard and novel therapies in haematological malignancies." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8532.

Full text

Abstract:

Despite improved treatments for Non-Hodgkin’s Lymphoma (NHL) and Multiple Myeloma (MM), most patients eventually relapse and these diseases remain largely incurable. This has precipitated recent research into more clinically relevant in vitro models to enable development of more effective therapies. We have validated and standardised two in vitro primary culture models using tumour samples derived from patients with NHL, Chronic Lymphocytic Leukaemia (CLL) and MM. Several novel findings have been demonstrated. In vitro sensitivity of primary NHL cells cocultured in a CD40L model predicted clinical response to bortezomib in patients receiving the drug in a phase II trial. In vitro sensitivity correlated with CD40 expression, identifying a potential surrogate biomarker for response to bortezomib. The novel HDAC inhibitor, UCL67022 was 10-fold more potent than vorinostat in NHL and produced synergy when combined with bortezomib. UCL67022 maintained its potency in primary MM samples grown in an HS-5 stromal model. It modulated cytokine secretion resulting in downregulation of cytokine-induced signalling pathways (JAK/STAT3). A novel Hsp90 inhibitor, KW-2478 maintained activity in the HS-5 model and enhanced the activity of bortezomib and melphalan. Hsp70 was identified as a potential surrogate biomarker to monitor the combinatorial effect in future clinical trials. A highly synergistic and schedule-dependent cytotoxic effect occurred when primary MM cells were pre-treated with melphalan followed by bortezomib, with important implications for future clinical trial design. IL-6, IL-8 and VEGF levels correlated with resistance to bortezomib and melphalan and were associated with activation of JAK/STAT, MAPK and PI3K/Akt signalling pathways. Antibody neutralization of IL-6, IL-8 and VEGF resulted in restoration of drug sensitivity. We have therefore demonstrated the ability of primary culture models to predict response to chemotherapy, to identify therapeutically beneficial novel agents and to enable study of tumour microenvironmental interactions responsible for drug resistance in patients with haematological malignancies.

APA, Harvard, Vancouver, ISO, and other styles

5

Hartman, Mikael. "Risk and prognosis of breast cancer among women at high risk of the disease /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-303-0/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Duberg, Ann-Sofi. "Hepatitis C virus infection a nationwide study of associated morbidity and mortality /." Doctoral thesis, Örebro : Örebro universitet, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7835.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Ye, Y. "Temporal trends in the risk of multiple primary cancers and competing mortality among adult-onset cancer patients." Thesis, 2018. https://eprints.utas.edu.au/30236/1/Ye_whole_thesis.pdf.

Full text

Abstract:

\(Background:\) Cancer patients are at risk of developing multiple primary cancers (MPCs). MPCs and non-cancer events compete with first cancers as the cause of death. This thesis aims to investigate temporal trends in the risk of MPCs and competing mortality due to MPCs and non-cancer events among adult-onset cancer patients in Tasmania. \(Methods:\) A systematic review of temporal trends in the risk of MPCs was performed. Original data were extracted from the population-based Tasmanian Cancer Registry in Australia. Patients with a first cancer registered between 1980-2009 were followed for incident second cancers to 2013 and for deaths to 2014. For non-cancer mortality, patients with a first cancer registered between 2006-2013 were followed up to 2015. MPC risks were quantified and trends in MPC risk were assessed in multivariable Poisson models. Mortality due to MPCs and non-cancer events were assessed in competing risk models. \(Results:\) The systematic review indicated an increasing trend in the risk of MPCs from the 1980s to 2000 in studies from Australia and the USA. In Tasmania, there was an increasing trend in the risk of any second cancer from 1980-2013. The competing mortality due to MPCs increased from the 1980s to a peak for first cancers diagnosed in 1995-1999. From 2006-2015, the competing mortality due to cardiovascular events increased significantly with age at first cancer diagnosis and exceeded other competing events at age 65 years or older. \(Conclusions:\) In Tasmania, the risk of MPCs has increased with periods of first cancer diagnosis from 1980-2009. The competing mortality due to MPCs increased for first cancers diagnosed in the 1990s possibly indicating overdiagnosis of non-fatal first cancers in the 1990s. Cardiovascular events were the leading cause of competing mortality among Tasmanian patients diagnosed with a first cancer from 2006-2013 suggesting potential opportunities for preventive interventions

APA, Harvard, Vancouver, ISO, and other styles

8

Lee, Tzu-Cheng, and 李姿政. "A Study on the Illness Experience and Adaptation Process of a Cancer Patient with Multiple Primary Cancers Diagnosed." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/57166683820281464030.

Full text

Abstract:

碩士<br>南華大學<br>生死學系碩士班<br>104<br>The theme of this study is the illness and adaptation experience of a patient with multiple primary cancers diagnosed. The research was guided by hermeneutic phenomenological research method. One patient was recruited as research participant through purposive sampling. In-depth interviews were conducted to collect data. The interview contents were transcribed verbatim and analyzed subsequently. The text was read back and forth among four levels: textual contents, units of meaning, textual contexts, interpretive structures till a conclusion reached. The findings were as follows: (1) the limited experience of space-time, (2) three psychological turning points on individual, family, and thinking levels, (3) three adaptation levels in terms of inner psyche, body management, and family strength, (4) the importance of interpretive scheme on illness experience. Different from the mainstream views, the results of this study revealed the care information about a patient with multiple primary cancers diagnosed. They can be taken as references for the patient, family members, and clinical professionals.

APA, Harvard, Vancouver, ISO, and other styles

9

Marinho, Pedro André Vasconcelos. "Neoplasia de cabeça e pescoço: ocorrência de tumores primários múltiplos." Master's thesis, 2018. http://hdl.handle.net/10284/7615.

Full text

Abstract:

Têm-se verificado um aumento na incidência de tumores primários múltiplos (TPM), estes caracterizam-se pela existência de dois ou mais tumores primários com origem numa dada região. A cancerização em campo é uma teoria que explica o aparecimento de TPM. Fatores de risco como álcool e tabaco estão relacionados com o desenvolvimento deste campo. Outros fatores como o Vírus do Papiloma Humano (HPV) podem também estar envolvidos na origem de TPM. O aparecimento de TPM é uma das principais causas de morte em pacientes com cancro de cabeça e pescoço (CCP), deste modo é essencial proceder ao seu diagnóstico precoce para obter um melhor prognóstico.<br>There has been an increase in the incidence of multiple primary tumors (PMS), these are characterized by the existence of two or more primary tumors originating in a given region. Field cancerization is a theory that explains the appearance of PMS. Risk factors such as alcohol and tobacco are related to the development of this field. Other factors such as Human Papilloma Virus (HPV) may also be involved in the origin of PMS. The appearance of PMS is of the leading causes of death in patients with head and neck cancer (CCP), so it is essential to make an early diagnosis to obtain a better prognosis.

APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Multiple primary cancers"

1

service), SpringerLink (Online, ed. Multiple Primary Malignancies. Springer Milan, 2009.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

2

Dakubo, Gabriel D. Field cancerization: Basic science and clinical applications. Nova Science, 2011.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

3

Morton, Lindsay M., Sharon A. Savage, and Smita Bhatia. Multiple Primary Cancers. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0060.

Full text

Abstract:

As prognosis following a cancer diagnosis has improved and survival has increased, so has the occurrence of multiple primary cancers diagnosed in the same individual. In the United States, one in five cancer diagnoses involves an individual with a previous history of cancer. These new primary cancer diagnoses, or “subsequent neoplasms” (SN), are a substantial cause of morbidity and mortality in cancer survivors. The risk of developing SN varies substantially depending on age, the type of initial primary cancer, chemotherapy, radiotherapy, genetic susceptibility, and exposure to other cancer risk factors. Childhood cancer survivors have particularly elevated SN risks associated with radiotherapy and, to a lesser extent, systemic therapy. Genetic susceptibility to cancer is also thought to play an important role in SN development after childhood cancer. Survivors of many adulthood cancers also have elevated SN risks, likely with a multifactorial etiology.

APA, Harvard, Vancouver, ISO, and other styles

4

I, Neugut Alfred, Meadows Anna T, and Robinson Eliezer, eds. Multiple primary cancers. Lippincott Williams & Wilkins, 1999.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

5

D, Boice John, National Cancer Institute (U.S.), Landsforeningen til kraeftens bekaempelse (Denmark), Cancerregisteret (Denmark), and Connecticut Tumor Registry, eds. Multiple primary cancers in Conecticut and Denmark. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute ; Washington, D.C. : For sale only by the Supt. of Docs., U.S. G.P.O., 1985.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

6

Multiple primary cancers in Connecticut and Denmark. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, 1985.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

7

D, Boice John, Connecticut Tumor Registry, Cancerregisteret (Denmark), and National Cancer Institute (U.S.), eds. Multiple primary cancers in Connecticut and Denmark. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, 1985.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

8

National Cancer Institute (U.S.), ed. Multiple primary cancers in Connecticut and Denmark. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, 1985.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

9

Mirabello, Lisa, Rochelle E. Curtis, and Sharon A. Savage. Bone Cancers. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0042.

Full text

Abstract:

Cancers arising from bone or cartilage account for about 0.2% of malignant neoplasms. They are histologically heterogeneous with multiple rare subtypes. Osteosarcoma and Ewing sarcoma occur primarily in children and young adults, whereas other bone cancers occur in older individuals. As a group, bone cancers have few known environmental risk factors, the exception being a strong association between therapeutic radiation and increased risk of osteosarcoma. The genetic etiology is also better understood in osteosarcoma, although there have been limited studies in other types of bone cancers. This chapter reviews the worldwide incidence of more common types of primary bone cancers, patterns in survival over time, and the associated environmental and genetic risk factors.

APA, Harvard, Vancouver, ISO, and other styles

10

Thun, Michael J., Martha S. Linet, James R. Cerhan, Christopher Haiman, and David Schottenfeld. Primary Prevention of Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0062.

Full text

Abstract:

Primary prevention has enormous potential to reduce the human, social, and economic costs of cancer worldwide. The following sections discuss the development and application of preventive interventions in six broad areas of public health: tobacco control, the prevention of obesity and physical inactivity, prevention of infection-related cancers, protection against excessive exposure to ultraviolet light, preventive drug therapies (chemoprevention), and the regulation of carcinogenic exposures. All of these areas affect multiple types of cancer and massive numbers of people. Different interventions are at varying stages of development. For example, effective, evidence-based approaches have been developed over several decades to reduce tobacco use, prevent chronic infection with hepatitis B virus, protect children from excessive sun exposure, regulate exposures in high-income countries, and reduce breast cancer incidence and recurrence in high-risk women. More recent efforts are seeking to identify upstream measures to prevent excessive weight gain, reduce caloric intake, and increase physical activity.

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Multiple primary cancers"

1

Soerjomataram, Isabelle, and Jan Willem Coebergh. "Epidemiology of Multiple Primary Cancers." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-416-2_5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Travis, Lois B., and Andrea K. Ng. "The Bioepidemiology of Multiple Primary Cancers." In ALERT - Adverse Late Effects of Cancer Treatment. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-72314-1_15.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Zheng, Xiangpeng. "Multiple Primary Early-Stage Lung Cancer." In Early-stage Lung Cancer. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-7596-4_10.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Takasaki, Ken, and Atsushi Aruga. "Multidisciplinary treatment for multiple hepatocellular carcinoma." In Primary Liver Cancer in Japan. Springer Japan, 1992. http://dx.doi.org/10.1007/978-4-431-68177-9_33.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Tadmor, Ciporah S. "Cancer: Multiple Services for Children Dying of Cancer and for Their Families." In Encyclopedia of Primary Prevention and Health Promotion. Springer US, 2014. http://dx.doi.org/10.1007/978-1-4614-5999-6_310.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Kamakura, Mitsuhiro, Haruo Kondo, and Shaw Watanabe. "Multiple Primary Neoplasms: Comparison Between Japan and the U.S.A." In Etiology of Cancer in Man. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-2532-8_5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Maeta, Michio, Akira Kondo, Syunsuke Shibata, Hiroshi Yamashiro, and Nobuaki Kaibara. "Esophageal Cancer Associated with Multiple Primary or Intramural Metastatic Lesions." In Recent Advances in Diseases of the Esophagus. Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-68246-2_77.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Stachowicz-Stencel, Teresa. "Pediatric Multiple Primary Cranio-Spinal Tumors Associated with Neurofibromatosis Type 2: Combined Therapeutical Strategies." In Pediatric Cancer, Volume 3. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4528-5_24.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Wu, Wen-Sheng, and Chi-Tan Hu. "Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways." In Signal Transduction in Cancer Metastasis. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9522-0_2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Perez, Carlos Hernandez, Marc Combalia Escudero, Susana Puig, Josep Malvehy, and Veronica Vilaplana Besler. "Contrastive and Attention-Based Multiple Instance Learning for the Prediction of Sentinel Lymph Node Status from Histopathologies of Primary Melanoma Tumours." In Cancer Prevention Through Early Detection. Springer Nature Switzerland, 2022. http://dx.doi.org/10.1007/978-3-031-17979-2_6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Multiple primary cancers"

1

Rashdan, L., Y. Zayed, and G. Bachuwa. "Metachronous Multiple Primary Lung Cancers (MPLC)." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5768.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Luo, Wenxin, and Wenmin Li. "Synchronous multiple primary lung cancers manifesting as multiple ground-glass nodules define a special clinical subtype." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.1747.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Wenz, Brandon, Kara N. Maxwell, Bradley Wubbenhorst, et al. "Abstract 4663: Identification of germline variants in cancer susceptibility genes in patients with multiple primary cancers." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4663.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Reis, Gabriel Baêta Branquinho, Hugo Francisco da Fonseca Neto, Alice Jardim Zaccariotti, et al. "INVASIVE DUCTAL CARCINOMA IN A PATIENT WITH LI-FRAUMENI SYNDROME: A CASE REPORT." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2105.

Full text

Abstract:

Introduction/Objectives: Breast cancer is one of the most common malignancies among women, with 10% resulting from genetic predisposition. Li-Fraumeni syndrome is an autosomal dominant disease that predisposes to multiple primary tumors and is responsible for less than 0.1% of breast cancers, being considered in early-onset tumors. The aim of this report was to describe a fast evolution of three primary tumors in a young patient with Li-Fraumeni syndrome, including ductal breast carcinoma. Case Report: In 2017, a 27-year-old female patient was diagnosed with malignant cancer of the right breast, Luminal HER KI67 70%, clinical stage IV (liver and lung), underwent first-line cancer treatment, maintaining endocrinotherapy and Double Block, with a positive genetic panel test for TP53 mutation, inferring SLF. In 2018, screening colonoscopy showed colon adenocarcinoma, pT53pN1, treated with total colectomy with ileal pouch, followed by suspension of endocrinotherapy and maintenance of Double Block and adjuvant FOLFOX. At the end of chemotherapy, endocrinotherapy was adopted again. Reassessment tests showed partial response in the liver, but the primary nodules were unchanged. Biopsy after thoracoscopy described lung adenocarcinoma, pT3pN2, submitted to adjuvant with Gemzar and Navelbine, followed by Double Block and interruption of endocrinotherapy. It evolved with the appearance of nodules in the right breast, suggestive of progression of breast disease, under treatment with Xeloda, Herceptin, and Perjeta, showing good clinical response. Discussion: Breast cancer in young people increases the possibility of heredity, thus raising the need for investigations of genetic syndromes. Although rare, the identification of FHL brings an important implication for the genetic counseling. Early diagnosis is the best form of management, enabling the preventive screening and intervention of multiple malignancies. Conclusion: Cases of breast cancer in young women should raise a suspected diagnosis of Li-Fraumeni syndrome, which can change the therapeutic and investigation of other cancers at an early stage.

APA, Harvard, Vancouver, ISO, and other styles

5

Izumi, Motohiro, Jun Oyanagi, Kenji Sawa, et al. "Abstract 2333: Mutational landscape of multiple primary lung cancers and its correlation with environmental factors." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2333.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Shin, Seung Jun, Elissa Dodd, Gang Peng, et al. "Abstract 2434: Characterizing age-of-onset of multiple primary cancers and specific cancer types in families with Li-Fraumeni syndrome." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2434.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Shin, Seung Jun, Elissa Dodd, Gang Peng, et al. "Abstract 2434: Characterizing age-of-onset of multiple primary cancers and specific cancer types in families with Li-Fraumeni syndrome." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2434.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Liang, Naixin, Zhongxing Bing, Yang Song, et al. "Abstract 5887: Clonal heterogeneity and evolution of multifocal lung cancers revealed by whole exome sequencing to facilitate molecular diagnosis of multiple primary lung cancers." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5887.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Wang, Ruoyu, Dewei Zhao, Zhiqiang Wang, et al. "Abstract 21: Mutation profiling of patients with multiple primary cancers reveals some common genomic alterations in signaling pathways." In Abstracts: AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; June 13-16, 2015; Salt Lake City, UT. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3265.pmsclingen15-21.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Rabin, Yoed, Thomas B. Julian, Peter Olson, Michael J. Taylor, and Norman Wolmark. "Cryosurgery for Breast Malignancies: Apparatus and Techniques." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0585.

Full text

Abstract:

Abstract The treatment of breast cancer has evolved from the time of mutilation and ignorance in the middle ages, to one of breast conserving management and an intense study and understanding of the biological mechanisms driving tumor cells. As the treatment is directed to the cellular and sub-cellular level, breast conserving surgical procedures take on a more important role. Recent published results from neoadjuvant trials indicate a decrease in tumor size in 80% of patients and a modest increase in conversion from mastectomy to lumpectomy. By 2010 AD, it is estimated that 50% of all new breast cancers discovered will be less than 10 mm in diameter (Cady et al., 1996), which represents 90,000 patients. Standard surgical treatment would require an open segment resection, an operating room, anesthesia, cosmetic concerns and substantial cost. Add to this the number of patients who require segmental resection following complete clinical or pathological response following neoadjuvant chemotherapy, and the cost increases. An alternative method of tumor removal or destruction for small malignancies is needed to complete the biological assault on breast cancer. Cryosurgery may be one of these alternative means. Cryosurgery has been used successfully for more than three decades to treat benign and malignant neoplasms. To date, there is one reported case of primary breast cancer treatment with cryotherapy (Staren et al., 1997), which was followed up with ultrasound-guided biopsy, and which was found negative for malignancy 12 weeks post-cryosurgery. Cryotherapy carries many benefits in addition to the attractive concept of minimally invasive surgery. Low temperatures generate anaesthetic effect. Hemorrhage is reduced due to thrombosis of small blood vessels. Cryotherapy may cause stimulation of the body’s immune system, which additionally augments local tumor destruction and may also induce a response in metastatic tumor sites (Suzuki, 1995). With multiple treatments such as neoadjuvant therapy, hormone therapy, and radiation, which have the ability to downsize primary cancers and treat small cancers, lumpectomy may be increasingly used. Current diagnostic imaging trends are increasingly detecting small cancers (&lt; 1 cm). The minimization of surgical intervention to compliment these trends is a natural progression of technology and understanding of the biological processes involved. Our ongoing research program to evaluate cryosurgery in the breast is comprised of several phases: (i) development of a miniaturized cryoprobe and a cryodevice for minimally invasive breast cryosurgery; (ii) validation testing of the cryoprobe and device in vivo; (iii) development of a technique to evaluate the injury associated with cryotreatment of the breast; (iv) comparison of the ultrasound imaged “‘ice-ball” in vivo with the resulting cryoinjury immediately post-cryosurgery; and, (v) long-term follow-up post-cryosurgery in a recently-pregnant sheep breast model. The work to date is part of this report.

APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Multiple primary cancers"

1

Horvit, Andrew, and Donald Molony. A Systematic Review and Meta-Analysis of Mortality and Kidney Function in Uranium – Exposed Individuals. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.4.0122.

Full text

Abstract:

Review question / Objective: 1) In humans, how does environmental and/or occupational exposure to uranium affect the risk of mortality due to primary kidney disease compared to unexposed individuals? (2) In humans, how does environmental and/or occupational exposure to uranium affect the risk of developing kidney failure compared to unexposed individuals? Eligibility criteria: We included cohort studies that evaluate the risk of CKD/ESKD due to uranium exposure. We also included cohort studies that evaluate standardized mortality due to all-cause mortality, kidney cancer, chronic kidney disease, diabetes, and cardiovascular disease in humans with exposure to uranium. We also included cross sectional studies that evaluate renal function in humans exposed to uranium via biomarkers and hard clinical measures (such as creatinine clearance) compared to humans with low/no uranium exposure. In order to not include the same cohort multiple times in the statistical analyses, we selected studies that evaluated an outcome of interest for a given cohort for the longest follow-up period. When this was not possible (due to multiple studies using different combinations of cohorts with varying lengths of follow up), the study with the largest study population size was selected.

APA, Harvard, Vancouver, ISO, and other styles

2

Skelly, Andrea C., Roger Chou, Joseph R. Dettori, et al. Integrated and Comprehensive Pain Management Programs: Effectiveness and Harms. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccer251.

Full text

Abstract:

Objectives. To evaluate the effectiveness and harms of pain management programs that are based on the biopsychosocial model of care, particularly in the Medicare population. Data sources. Electronic databases (Ovid® MEDLINE®, PsycINFO®, CINAHL®, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews) from 1989 to May 24, 2021; reference lists; and a Federal Register notice. Review methods. Given lack of consensus on terminology and program definition for pain management, we defined programs as integrated (based in and integrated with primary care) and comprehensive (referral based and separate from primary care) pain management programs (IPMPs and CPMPs). Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) comparing IPMPs and CPMPs with usual care or waitlist, physical activity, pharmacologic therapy, and psychological therapy in patients with complex acute/subacute pain or chronic nonactive cancer pain. Patients needed to have access to medication support/review, psychological support, and physical function support in programs. Meta-analyses were conducted to improve estimate precision. We classified the magnitude of effects as small, moderate, or large based on predefined criteria. Strength of evidence (SOE) was assessed for the primary outcomes of pain, function, and change in opioid use. Results. We included 57 RCTs; 8 evaluated IPMPs and 49 evaluated CPMPs. Compared with usual care or waitlist, IPMPs were associated with small improvements in pain in the short and intermediate term (SOE: low) and in function in the short term (SOE: moderate), but there were no clear differences at other time points. CPMPs were associated with small improvements in pain immediately postintervention (SOE: moderate) but no differences in the short, intermediate, and long term (SOE: low); for function, improvements were moderate immediately postintervention and in the short term; there were no differences in the intermediate or long term (SOE: low at all time points). CPMPs were associated with small to moderate improvements in function and pain versus pharmacologic treatment alone at multiple time frames (SOE: moderate for function intermediate term; low for pain and function at all other times), and with small improvements in function but no improvements in pain in the short term when compared with physical activity alone (SOE: moderate). There were no differences between CPMPs and psychological therapy alone at any time (SOE: low). Serious harms were not reported, although evidence on harms was insufficient. The mean age was 57 years across IPMP RCTs and 45 years across CPMP RCTs. None of the trials specifically enrolled Medicare beneficiaries. Evidence on factors related to program structure, delivery, coordination, and components that may impact outcomes is sparse and there was substantial variability across studies on these factors. Conclusions. IPMPs and CPMPs may provide small to moderate improvements in function and small improvements in pain in patients with chronic pain compared with usual care. Formal pain management programs have not been widely implemented in the United States for general populations or the Medicare population. To the extent that programs are tailored to patients’ needs, our findings are potentially applicable to the Medicare population. Programs that address a range of biopsychosocial aspects of pain, tailor components to patient need, and coordinate care may be of particular importance in this population.

APA, Harvard, Vancouver, ISO, and other styles

3

MacFarlane, Andrew. 2021 medical student essay prize winner - A case of grief. Society for Academic Primary Care, 2021. http://dx.doi.org/10.37361/medstudessay.2021.1.1.

Full text

Abstract:

As a student undertaking a Longitudinal Integrated Clerkship (LIC)1 based in a GP practice in a rural community in the North of Scotland, I have been lucky to be given responsibility and my own clinic lists. Every day I conduct consultations that change my practice: the challenge of clinically applying the theory I have studied, controlling a consultation and efficiently exploring a patient's problems, empathising with and empowering them to play a part in their own care2 – and most difficult I feel – dealing with the vast amount of uncertainty that medicine, and particularly primary care, presents to both clinician and patient. I initially consulted with a lady in her 60s who attended with her husband, complaining of severe lower back pain who was very difficult to assess due to her pain level. Her husband was understandably concerned about the degree of pain she was in. After assessment and discussion with one of the GPs, we agreed some pain relief and a physio assessment in the next few days would be a practical plan. The patient had one red flag, some leg weakness and numbness, which was her ‘normal’ on account of her multiple sclerosis. At the physio assessment a few days later, the physio felt things were worse and some urgent bloods were ordered, unfortunately finding raised cancer and inflammatory markers. A CT scan of the lung found widespread cancer, a later CT of the head after some developing some acute confusion found brain metastases, and a week and a half after presenting to me, the patient sadly died in hospital. While that was all impactful enough on me, it was the follow-up appointment with the husband who attended on the last triage slot of the evening two weeks later that I found completely altered my understanding of grief and the mourning of a loved one. The husband had asked to speak to a Andrew MacFarlane Year 3 ScotGEM Medical Student 2 doctor just to talk about what had happened to his wife. The GP decided that it would be better if he came into the practice - strictly he probably should have been consulted with over the phone due to coronavirus restrictions - but he was asked what he would prefer and he opted to come in. I sat in on the consultation, I had been helping with any examinations the triage doctor needed and I recognised that this was the husband of the lady I had seen a few weeks earlier. He came in and sat down, head lowered, hands fiddling with the zip on his jacket, trying to find what to say. The GP sat, turned so that they were opposite each other with no desk between them - I was seated off to the side, an onlooker, but acknowledged by the patient with a kind nod when he entered the room. The GP asked gently, “How are you doing?” and roughly 30 seconds passed (a long time in a conversation) before the patient spoke. “I just really miss her…” he whispered with great effort, “I don’t understand how this all happened.” Over the next 45 minutes, he spoke about his wife, how much pain she had been in, the rapid deterioration he witnessed, the cancer being found, and cruelly how she had passed away after he had gone home to get some rest after being by her bedside all day in the hospital. He talked about how they had met, how much he missed her, how empty the house felt without her, and asking himself and us how he was meant to move forward with his life. He had a lot of questions for us, and for himself. Had we missed anything – had he missed anything? The GP really just listened for almost the whole consultation, speaking to him gently, reassuring him that this wasn’t his or anyone’s fault. She stated that this was an awful time for him and that what he was feeling was entirely normal and something we will all universally go through. She emphasised that while it wasn’t helpful at the moment, that things would get better over time.3 He was really glad I was there – having shared a consultation with his wife and I – he thanked me emphatically even though I felt like I hadn’t really helped at all. After some tears, frequent moments of silence and a lot of questions, he left having gotten a lot off his chest. “You just have to listen to people, be there for them as they go through things, and answer their questions as best you can” urged my GP as we discussed the case when the patient left. Almost all family caregivers contact their GP with regards to grief and this consultation really made me realise how important an aspect of my practice it will be in the future.4 It has also made me reflect on the emphasis on undergraduate teaching around ‘breaking bad news’ to patients, but nothing taught about when patients are in the process of grieving further down the line.5 The skill Andrew MacFarlane Year 3 ScotGEM Medical Student 3 required to manage a grieving patient is not one limited to general practice. Patients may grieve the loss of function from acute trauma through to chronic illness in all specialties of medicine - in addition to ‘traditional’ grief from loss of family or friends.6 There wasn’t anything ‘medical’ in the consultation, but I came away from it with a real sense of purpose as to why this career is such a privilege. We look after patients so they can spend as much quality time as they are given with their loved ones, and their loved ones are the ones we care for after they are gone. We as doctors are the constant, and we have to meet patients with compassion at their most difficult times – because it is as much a part of the job as the knowledge and the science – and it is the part of us that patients will remember long after they leave our clinic room. Word Count: 993 words References 1. ScotGEM MBChB - Subjects - University of St Andrews [Internet]. [cited 2021 Mar 27]. Available from: https://www.st-andrews.ac.uk/subjects/medicine/scotgem-mbchb/ 2. Shared decision making in realistic medicine: what works - gov.scot [Internet]. [cited 2021 Mar 27]. Available from: https://www.gov.scot/publications/works-support-promote-shared-decisionmaking-synthesis-recent-evidence/pages/1/ 3. Ghesquiere AR, Patel SR, Kaplan DB, Bruce ML. Primary care providers’ bereavement care practices: Recommendations for research directions. Int J Geriatr Psychiatry. 2014 Dec;29(12):1221–9. 4. Nielsen MK, Christensen K, Neergaard MA, Bidstrup PE, Guldin M-B. Grief symptoms and primary care use: a prospective study of family caregivers. BJGP Open [Internet]. 2020 Aug 1 [cited 2021 Mar 27];4(3). Available from: https://bjgpopen.org/content/4/3/bjgpopen20X101063 5. O’Connor M, Breen LJ. General Practitioners’ experiences of bereavement care and their educational support needs: a qualitative study. BMC Medical Education. 2014 Mar 27;14(1):59. 6. Sikstrom L, Saikaly R, Ferguson G, Mosher PJ, Bonato S, Soklaridis S. Being there: A scoping review of grief support training in medical education. PLOS ONE. 2019 Nov 27;14(11):e0224325.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!