Relevant bibliographies by topics / Multiple Sclerosis (MS) sufferers

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Multiple Sclerosis (MS) sufferers'

Author: Grafiati
Published: 19 February 2023

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Journal articles on the topic "Multiple Sclerosis (MS) sufferers"

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Pérez, C. Ayán, V. Martín Sánchez, F. De Souza Teixeira, and J. A. De Paz Fernández. "Effects of a Resistance Training Program in Multiple Sclerosis Spanish Patients: A Pilot Study." Journal of Sport Rehabilitation 16, no. 2 (May 2007): 143–53. http://dx.doi.org/10.1123/jsr.16.2.143.

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Context:Physical exercise is regarded as a useful tool in the treatment of multiple sclerosis (MS). Generally, physical rehabilitation have been based on the prescription of aerobic exercises, while fewer programs have been aimed at developing muscular strength.Objective:To establish whether the physical fitness of MS sufferers can be improved by a training program for developing muscular strength.Design:Before and after studySetting:University multipurpose roomParticipants:36 patients, all able to walk, belonging to the Leon Multiple Sclerosis Association.Interventions:The physical exercise programme consisted in resistance training sessions, based mainly on callisthenic, or bodyweight, exercises, during six weeks.
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Stojanov, Aleksandar, and Jelena Stojanov. "Depression as a determinant of quality of life in patients with multiple sclerosis." Galenika Medical Journal 1, no. 3 (2022): 22–27. http://dx.doi.org/10.5937/galmed2203023s.

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Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS), which mainly affects women and young adults in their most productive years of life. Given to fact that the disease is unpredictable and has uncertain outcomes, the grater are physical and emotional efforts that an individual has to take, and that inevitably causes additional exhaustion. Assessment of disease severity based only on an objective clinical finding is not enough, because it does not give insight into the subjective experience of disease symptoms and difficulties with which these patients meet in everyday life life. Most MS sufferers most likely will experience a wide range of physical, psychological and social problems. Physical disability, fatigue, motor incapacity and sexual dysfunctions that occur with the progression of the disease, most often lead to the deterioration of the quality of life in people with MS. In addition to these factors, changes in psychological status are inevitable. Depression is the most common psychiatric comorbidity of MS that worsens the health condition of the patient. Studies on psychiatric comorbidities and ways of coping with MS generally highlight the connection between depression and alexithymia in MS. Prevalence alexithymia in MS patients goes up to 50%, it is associated with anxiety and significantly contributes to the severity and severity of depression. When it comes to the therapy of depression in MS of cognitive-behavioral psychotherapy (CBT) is recommended as the first line of treatment, but also the application of pharmacotherapy i.e. administration of sertraline and escitalopram with short-term use of alprazolam, and more recently, more and more studies are investigating neuroprotective effect of antidepressants, and recommend the use of fluoxetine. Directing preventive measures to improving social activities and prevention institutionalization ie. combining medical rehabilitation, psychosocial help and social support prevent that the disease from becoming a disability leading to complete isolation. It is also necessary to direct resources to adequate treatment of depression as determining factor of quality of life, mental health and prognostic factor of the clinical picture and course of MS.
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Mirmosayyeb, Omid, Serge Brand, Mahdi Barzegar, Alireza Afshari-Safavi, Nasim Nehzat, Vahid Shaygannejad, and Dena Sadeghi Bahmani. "Clinical Characteristics and Disability Progression of Early- and Late-Onset Multiple Sclerosis Compared to Adult-Onset Multiple Sclerosis." Journal of Clinical Medicine 9, no. 5 (May 2, 2020): 1326. http://dx.doi.org/10.3390/jcm9051326.

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Background: Compared to the adult onset of multiple sclerosis (AOMS), both early-onset (EOMS) and late-onset (LOMS) are much less frequent, but are often under- or misdiagnosed. The aims of the present study were: 1. To compare demographic and clinical features of individuals with EOMS, AOMS and LOMS, and 2. To identify predictors for disability progression from relapsing remitting MS (RRMS) to secondary progressive MS (SPMS). Method: Data were taken from the Isfahan Hakim MS database. Cases were classified as EOMS (MS onset ≤ 18 years), LOMS (MS onset >50 years) and AOMS (MS >18 and ≤ 50 years). Patients’ demographic and clinical (initial symptoms; course of disease; disease patterns from MRI; disease progress) information were gathered and assessed. Kaplan–Meier and Cox proportional hazard regressions were conducted to determine differences between the three groups in the time lapse in conversion from relapsing remitting MS to secondary progressive MS. Results: A total of 2627 MS cases were assessed; of these 127 were EOMS, 84 LOMS and 2416 AOMS. The mean age of those with EOMS was 14.5 years; key symptoms were visual impairments, brain stem dysfunction, sensory disturbances and motor dysfunctions. On average, 24.6 years after disease onset, 14.2% with relapsing remitting MS (RRMS) were diagnosed with secondary progressive MS (SPMS). The key predictor variable was a higher Expanded Disability Status Scale (EDSS) score at disease onset. Compared to individuals with AOMS and LOMS, those with EOMS more often had one or two relapses in the first two years, and more often gadolinium-enhancing brain lesions. For individuals with AOMS, mean age was 29.4 years; key symptoms were sensory disturbances, motor dysfunctions and visual impairments. On average, 20.5 years after disease onset, 15.6% with RRMS progressed to SPMS. The key predictors at disease onset were: a higher EDSS score, younger age, a shorter inter-attack interval and spinal lesions. Compared to individuals with EOMS and LOMS, individuals with AOMS more often had either no or three and more relapses in the first two years. For individuals with LOMS, mean age was 53.8 years; key symptoms were motor dysfunctions, sensory disturbances and visual impairments. On average, 14 years after disease onset, 25.3% with RRMS switched to an SPMS. The key predictors at disease onset were: occurrence of spinal lesions and spinal gadolinium-enhancement. Compared to individuals with EOMS and AOMS, individuals with LOMS more often had no relapses in the first two years, and higher EDSS scores at disease onset and at follow-up. Conclusion: Among a large sample of MS sufferers, cases with early onset and late onset are observable. Individuals with early, adult and late onset MS each display distinct features which should be taken in consideration in their treatment.
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Svensson, Marianne, and Liberty Fajutrao. "Costs of Formal and Informal Home Care and Quality of Life for Patients with Multiple Sclerosis in Sweden." Multiple Sclerosis International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/529878.

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Disease progression in multiple sclerosis leads to dramatic changes in a person's ability to perform daily activities and increases reliance on external help. This study aims to describe and to estimate costs of formal/informal home care and quality of life related to multiple sclerosis. A mailed survey to a random sample of MS sufferers(n=1500)collected data on the number of hours of home care received, type of help, productivity losses, quality of life, and disease characteristics. Costs for home care were estimated in 2012 € and factors that may influence the likelihood of getting home care were also evaluated. Formal care was given to 27% of the respondents(n=839)at an average of 238.7 hrs/month at a mean monthly cost of €2873/person with MS. Informal care was received by 49% of the respondents at an average of 47.3 hrs/month at a mean monthly cost of €389/person with MS. Utilities across disease severity are as follows: mild MS = 0.709 (sd = 0.233), moderate MS = 0.562 (sd = 0.232), and severe MS = 0.284 (sd = 0.283). Total home care costs increased with increasing disease severity. Informal caregiving contributes significantly to MS home care in Sweden.
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Vojdani, Aristo, Partha Sarathi Mukherjee, Joshua Berookhim, and Datis Kharrazian. "Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis." Autoimmune Diseases 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/905208.

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Multiple sclerosis (MS) is an autoimmune disease that affects the body’s central nervous system. Around 90% of MS sufferers are diagnosed with relapsing-remitting MS (RRMS). We used ELISA to measure IgG, IgA, and IgM antibodies against linear epitopes of human and plant aquaporins (AQP4) as well as neural antigens in RRMS patients and controls to determine whether patients suffering from RRMS have simultaneous elevations in antibodies against these peptides and antigens. In comparison to controls, significant elevations in isotype-specific antibodies against human and plant AQP4 and neural antigens such as MBP, MOG, and S100B were detected in RRMS patients, indicating a high correlation in antibody reaction between plant aquaporins and brain antigens. This correlation between the reactivities of RRMS patients with various tested antigens was the most significant for the IgM isotype. We conclude that a subclass of patients with RRMS reacts to both plant and human AQP4 peptides. This immune reaction against different plant aquaporins may help in the development of dietary modifications for patients with MS and other neuroimmune disorders.
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Kirby, Trevor, and Javier Ochoa-Repáraz. "The Gut Microbiome in Multiple Sclerosis: A Potential Therapeutic Avenue." Medical Sciences 6, no. 3 (August 24, 2018): 69. http://dx.doi.org/10.3390/medsci6030069.

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Recently, there has been a substantial increase in the number of studies focused upon connecting the gut microbiome with cases of central nervous system (CNS) autoimmunity. Multiple sclerosis (MS) is a neurodegenerative autoimmune disorder of the CNS. Recent experimental and clinical evidence suggests the presence of microbial imbalances in the gut of MS sufferers. The gut microbiome is defined as the summation of all the microbial entities as well as their genes, proteins, and metabolic products in a given space and time. Studies show the MS gut microbiome as having general alterations in specific taxa, some associated with the promotion of inflammatory cytokines and overall inflammation. In conjunction with these findings, experimental models of the disease have reported that T regulatory (Treg) cells have deficits in their function as a result of the aberrant gut microbiota composition. The findings suggest that the interactions between the host and the microbiota are reciprocal, although more extensive work is required to confirm this. Moreover, evidence indicates that changes in microbiota composition may result in imbalances that could result in disease, with the gut as a potential novel therapeutic avenue. By understanding the biological effects of aberrant gut microbiome composition, it is possible to contemplate current therapeutic options and their efficacy. Ultimately, more research is necessary in this field, but targeting the gut microbiota may lead to the development of novel therapeutic strategies.
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Shannon, Brad C., and Shirley G. Tollman. "A Neuropsychological Examination of Multiple Sclerosis and its Impact upon Higher Mental Functions." South African Journal of Psychology 24, no. 3 (September 1994): 152–62. http://dx.doi.org/10.1177/008124639402400307.

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In view of the debate regarding the behavioural sequelae accompanying multiple sclerosis (MS), this study aimed to identify the deficits underlying observed behavioural performance difficulties in 24 MS sufferers. Qualitative and quantitative assessment instruments were employed, that is, Christensen's formalization of Luria's Neuropsychological Investigation, the Trail Making Test and Rey's Complex Figure Test. Results were analysed using syndrome analysis, which proceeded according to a hypothetico-deductive process, based on the principle of double dissociation of function. Five underlying factors were identified, namely: fatigability; information overload; disturbed fine control and integration of skilled motor movements; disturbed attention, concentration and tracking; and, disturbed executive control. Subjects divided into two subgroups. Those in subgroup 1 displayed fatigability, information overload and disturbed fine control and integration of skilled motor movement. In addition to these, subjects in subgroup 2 displayed disturbed attention, concentration and tracking, and disturbed executive skills. The identification of two subgroups may assist in explaining why controversy still surrounds the question of cognitive deficits in MS. It was concluded that the five underlying factors gave rise to a specific pattern of neuropsychological dysfunctioning in subjects consistent with a subcortical syndrome.
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Yousefi, Behzad, Samad Shams Vahdati, Hossein Mazouchian, and Reza Dehghan Hesari. "Epidemiological Survey of Multiple Sclerosis in East-Azerbaijan Province, Iran, 2014." Internal Medicine and Medical Investigation Journal 2, no. 2 (May 22, 2017): 42. http://dx.doi.org/10.24200/imminv.v2i2.54.

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Abstract:Introduction and background: MS as a chronic CNS disease is very prevalent in all around the world. Its epidemiology is different region by region and most of geographical and environmental factors may play a role in its incidence. To analyze demographic characteristics of the disease we designed this study.Methods and Materials: This Survey has been conducted in East-Azerbaijan province, North-West of Iran. Prevalence of the disease has been measured using data of Committee for diagnosis and Treatment of Multiple Sclerosis in 2014. Age, gender and type of the disease also been investigated in this research. Independent T Test, Chi square, Pearson and Fisher exact test used to analyze data.Results: We had 2774 MS patients in 2014. 726 were male (26%) and 2003 were female (73%). Mean age of males was 38±9 and mean age of females was 37.09±9. Mean age in male patients was more than in females significantly (P=0.001). We measured 73.26 prevalence per 100000 populations in East-Azerbaijan.Conclusion: Prevalence of the disease showed significant increase in 5 years compared to previous studies. Because of disease's disabilatating entity more interventional investigations are recommended to perform in preventing disease incidence or improving quality of life of sufferers and increasing their life expectancy.
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Viveiros, Cynthia Dumas, and Regina Maria Papais Alvarenga. "Prevalence of epilepsy in a case series of multiple sclerosis patients." Arquivos de Neuro-Psiquiatria 68, no. 5 (October 2010): 731–36. http://dx.doi.org/10.1590/s0004-282x2010000500011.

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OBJECTIVE: The prevalence of epilepsy in multiple sclerosis (MS) patients has been a subject of interest for some years. The objectives of this study were to describe the clinical, radiological and electroencephalographic characteristics of epileptic seizures and to calculate the prevalence of epilepsy in a case series of MS patients. METHOD: Medical charts of MS patients were reviewed and patients who had suffered epileptic seizures were identified. RESULTS: Of 160 cases analyzed, 5 had suffered epileptic seizures and one had comorbid mesial hippocampal sclerosis, confirmed by magnetic resonance imaging in a patient with complex partial seizures that began fifteen years prior to her diagnosis of MS. In the other four patients, seizures occurred both during the acute phase of the disease and in the chronic phase. CONCLUSION: The prevalence of epileptic seizures in MS patients in this study was 2.5%, similar to that found in other studies.
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Kania, Karolina, Elżbieta Tokarz-Kupczyk, and Alicja Kalinowska-Łyszczarz. "COVID-19 in two patients with multiple sclerosis treated with beta interferons." Pharmacotherapy in Psychiatry and Neurology 36, no. 4 (February 8, 2021): 327–34. http://dx.doi.org/10.33450/fpn.2020.12.004.

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Objectives. Treatment of multiple sclerosis (MS) in the era of the COVID-19 (coronavirus disease 2019) pandemic raises many questions for doctors. Case reports. We are presenting two cases of patients suffering from multiple sclerosis (MS) treated with interferon beta-1b and interferon beta-1a, who suffered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with a benign course in one case and an asymptomatic one in another. None of the patients required hospitalisation. Conclusions. MS treatment during coronavirus disease 2019 (COVID-19) pandemics poses several questions. Considering our own clinical experiences, we present a brief review of medical literature on the safety of MS immunotherapy. So far, the published data on MS and COVID-19 do not show increased risk associated with MS diagnosis or disease modifying therapy, even when associated with immunosuppression.
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Dissertations / Theses on the topic "Multiple Sclerosis (MS) sufferers"

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Foley, Peter Leonard. "Pain in multiple sclerosis." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28949.

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Background: Pain is frequently reported by people with multiple sclerosis (MS). It has been associated with decreased quality of life, psychiatric morbidity, interference with day to day activities, and frequent healthcare attendance. It has been reported by people with multiple sclerosis to be one of their most important symptoms, and available treatments are limited in their effectiveness. Despite this, our understanding of the epidemiology and mechanisms of pain in people with MS are limited. Our understanding of the interactions of central nervous system mechanisms and pain states overall is growing. However, the application of this knowledge to MS is incomplete. Previous studies have shown that the descending pain modulatory system (DPMS) is an endogenous network of cortical and subcortical brain structures which act to limit, or accentuate, an individual’s perception of pain, via descending brainstem pathways. Associated clinical measures include depression, anxiety, and cognitive flexibility. Our understanding of the function or dysfunction of this system in MS is limited. We do not know if the MS disease process may adversely affect the structure or function of the DPMS. Hypothesis: In people with neuropathic limb pain in relapsing remitting MS (RRMS), compared to people with RRMS who do not have pain, there will be disruption of the endogenous descending pain modulatory system. This will manifest as impaired descending inhibition of pain. Aims and Methods Establishing the background using systematic reviews: The first aim of this thesis was to establish the prevalence, natural history and associations of pain (and pain syndromes) occurring in people with MS. The second aim was to explore existing knowledge of how the MS disease process may contribute to pain states, using a systematic review of neuroimaging studies. Prospective clinical study: A case-control study of 47 people with RRMS was then carried out. 31 of these had neuropathic pain in the limbs, and 16 did not have pain. Using targeted assessments, function of the descending pain modulatory system was assessed in the following ways: First: Detailed clinical, behavioural and neuropsychological assessment, focussing on cognitive, behavioural and affective features known to be closely related to the DPMS. Second: MRI imaging of brain structure, focussing on the volume and location of MS lesions, as well as the volume of key grey-matter structures involved in the DPMS. Third: Resting state functional MRI imaging of the brain, focussing on functional connectivity between the rostral anterior cingulate cortex and two other key DPMS structures (dorsolateral prefrontal cortex, and periaqueductal gray). Results: Systematic reviews: Meta-analysis of existing prospective studies confirmed that pain is very common in MS, affecting about 63% of people with MS on average (95%CI between 55 and 70%). Many different types of pain contribute to this overall estimate. No significant associations with disease course or stage emerged. Several neuroimaging studies have assessed people with MS-associated pain using MRI. These studies were often small, and with associated methodological issues. It is likely that location of MS lesions is implicated in aetiology of pain syndromes in some cases, though our overall knowledge is limited. Prospective study: In a prospective study, people with and without pain were matched for age and gender. Furthermore, groups were balanced for a range of other variables. The pain group more frequently received gabapentinoid medications. The presence of pain was significantly associated with increased scores for depression, fatigue and catastrophising, as well as with specific impairments at neuropsychological assessment, including cognitive flexibility. Many of these impairments are directly relevant to existing models of the DPMS. Overall volume of MS lesions was not different in people with pain, though lesions were more likely to occur in the brainstem. Some alterations of grey-matter volumes in people with pain which mirrored studies of pain disorders outside MS were found, but these did not involve structures key to the DPMS. Affected structures included trigeminothalamic nucleus (relative volume increase in pain group), posterior cingulate cortex and parahippocampal gyrus (volume decrease in pain group). Functional connectivity of the rostral anterior cingulate cortex to the periaqueductal grey matter, a key structure in the descending modulation of pain, was stronger in the group without pain. Conversely, functional connectivity to the dorsolateral prefrontal cortex, repeatedly implicated in the DPMS and thought to be involved in cognitive evaluation and flexibility, was stronger in the pain group. MS lesion volume appeared to account for some of this difference in a multivariate analysis. Limitations: Key limitations of this work include cross-sectional design, small sample size, and number of statistical comparisons carried out. Conclusions: Systematic reviews examined the prevalence, natural history and associations of pain in MS, as well as examining existing neuroimaging studies which investigated how the MS disease process could contribute to pain states. A prospective study found evidence of both emotional/affective and cognitive dysfunctions relevant to the hypothesis of dysfunction in the DPMS. Higher likelihood of MS lesions in the brainstem could be relevant to DPMS function. Separately, there were structural grey-matter volume alterations reflecting those found in many pain studies outside MS. Importantly, however, these did not affect key DPMS structures. Resting state functional MRI however demonstrated altered connectivity of core DPMS structures, which may be partly mediated by MS lesion volume. Functional connectivity findings could be consistent with the hypothesis of impaired descending pain inhibition, in people with relapsing remitting MS affected by neuropathic limb pain.
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Craig, Charles J. "Studies of immunoregulation in Multiple Sclerosis." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328088.

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Evangelou, N. "Approaches to defining axonal loss in multiple sclerosis." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249538.

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Garrison, Jennifer H. "The Effect of an Online Coping Skill Application on Relapsing-Remitting Multiple Sclerosis Sufferers." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/236.

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Many individuals with multiple sclerosis (MS) are classified as having relapsing-remitting MS (RRMS), a form of the illness that requires constant symptom management for suffers to achieve optimum outcomes. There are only a few community-based educational programs that exist to help RRMS sufferers cope with their illness; the effectiveness of those that have been fielded has not yet been adequately assessed. The research questions of this study were to determine if an online training development module would increase the coping skills of those affected by RRMS and if the online educational module would be more effective at improving the coping skills of mild RRMS sufferers versus severe RRMS sufferers. The theoretical foundation was based on a stress-coping model commonly utilized for chronic disease management. The research design employed 2 groups, nonrandom selection, and use of a pretest/posttest applied to the target population from the Georgia MS Chapter. SPSS was used to perform statistical analysis as well as to perform the Mann-Whitney test on study data/results. According to findings from this quantitative study, the application of the online education development module to RRMS sufferers does provide a mechanism of significantly improving their coping skills. This positive social change improvement of coping strategies helps the patients as well as family, friends, and coworkers, and this module would serve as the complement to augment coping strategy improvement efforts for RRMS suffers. This study supports improvement of RRMS sufferer coping skills in the short term, and a future area of research focus would address the long-term improvements in coping skills for RRMS sufferers from the application of this online module.
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Thannhauser, Jennifer, and University of Lethbridge Faculty of Education. "The psychosocial experiences of individuals diagnosed with early-onset MS." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Education, 2005, 2005. http://hdl.handle.net/10133/284.

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This qualitative study explored the psychosocial experiences of children and adolescents with early-onset multiple sclerosis. In particular, an emphasis was placed on examing peer relationships and social behaviours in relation to these experiences. MS is a chronic neurological disease primarily affecting young adults. However, a proportion of MS patients have onset during childhood and adolescence. Very little is know about the psychosocial impact of MS on these children and adolescents. In particular, youth with MS may be at risk for negative peer experiences due to their chronic illness. Previous research suggested that negative peer experiences increase the risk of poor psychosocial development. In addition, research suggested that the social behaviours of these youth also impact the nature of their experiences with peers. Ultimately, this research aimed to provide insight into the psychoscial experiences of youth with MS and the role of their peer relationships. Six linked parent-youth pairs, from the MS Clinic in Calgary, AB, participated in semi-structured interviews to identify the issues that are pertinent to the participants' own experiences. Constant comparison analysis was then used to summarize the rante of psychosocial experiences in the adolescent participants. Data analysis was derived from grounded theory, which provided a framework for examining and categorizing interview data into themes. The categories were then constructed logically and systematically into a theoretical model which represented the data. Through this innovative grounded theory, a theoretical paradigm for understanding the psychosocial experiences of adolescents with MS was developed. The theory was comprised of two core categories: "the grief experience" and "dynamic relationships', each with several sub-categories. There were two primary conclusions drawn from the theory. The first reflected the significance of grief in understanding psychosocial experiences in adolescents with MS. The second identified that peer relationships play a variety of roles in this grief process. The second identified that peer relationships play a variety of roles in this grief process. The results of this study have many implications for the role of counsellors in the treatments of adolescents with MS. This model can act as a foundation for guiding therapeutic treatment of adolescents with MS. This model can act as a foundation for guiding therapeutic treatment and promoting future research in the area of psychosocial development in children and adolescents with early-onset MS.
xiv, 181 leaves ; 28 cm.
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Rogers, Stephen. "Glycosylation of immunoglobulin G in cerebrospinal fluid and multiple sclerosis." Thesis, University of Surrey, 2001. http://epubs.surrey.ac.uk/843781/.

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The glycosylation features of CSF oligoclonal IgG, and possible changes in N-glycans of CSF IgG in multiple sclerosis (MS) were studied. After isoelectric focusing (IEF) of CSF, bands were detected using biotinylated lectins and avidin-horseradish peroxidase. Concanavalin A (Con A) binding showed that mannose exists throughout the pH range of oligoclonal IgG. Sambucus nigra antigen (SNA) bound acidic and neutral oligoclonal IgG only, suggesting that alkaline oligoclonal IgG is deficient in sialic acid. Deglycosylation of CSF IgG using peptide-N-glycosidase F suggested that the range of isoelectric points of oligoclonal IgG bands is not due to carbohydrate differences alone. Lectin immunoassays, whereby protein A purified IgG was captured by anti-IgG coated tubes and probed using a range of biotinylated lectins, were used to compare 13 CSF samples from MS patients with 14 control samples. With Con A binding, a significantly higher mean and larger variance was found for the MS group (t-test: P < 0.05). Con A binding correlated with CSF [IgG]/[total protein]% (r=0.390; P=0.0443). Using HPLC to separate oligosaccharides released from IgG by hydrazinolysis and labelled with 2-aminobenzamide, glycans were determined in 7 CSF samples with oligoclonal IgG, and 6 CSF samples without. The ratio of the peak for biantennary fucosylated agalactosyl glycans to total monogalactosylated glycan peaks was lower for the oligoclonal IgG samples (t-test: P=0.0141). The overall results suggested that glycosylation changes occur in CSF IgG in MS, and that oligoclonal IgG contains less sialic acid but more galactose than polyclonal IgG.
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Brown, Nolan J. "Localization of hemoglobin in MS cortex and its relevance to MS neuropathology." Kent State University Honors College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399400834.

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Mann, C. L. A. "The relationship of genetic polymorphisms to disease severity of multiple sclerosis." Thesis, Keele University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341244.

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The glutathione S-transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress. Certain GST loci are polymorphic, demonstrating alleles that are null (GSTMI/GSTT1), encode low activity variants (GSTPI), or are associated with variable inducibility (GSTM3). Interleukin-1 (IL- 1) alpha and beta are cytokines involved in recruitment of inflammatory cells, the process of inflammation, and blood-brain barrier breakdown and nerve regeneration. Polymorphisms of both GST and of a complementary interleukin-1 receptor antagonist have been associated with severity and susceptibility to other inflammatory conditions. This thesis examines the influence of the GST and IL-1 genes on both the susceptibility to Multiple Sclerosis (MS), and the course of disease progression. The population examined consisted of four hundred patients with clinically definite MS. Disease severity was measured using the Kurtzke Expanded Disability Status Scale (EDSS), a robust established ranking scale. PCR-based genotyping was performed using DNA extracted from lymphocytes. Significant associations between genotypes and clinical outcome were corrected for known demographic factors influencing prognosis, these being; gender, onset age, and disease duration using the statistical method of logistic regression. Significant associations, withstanding multiple testing corrections, with certain IL-I genotypes and disease severity were found. There was also a significant trend with the GST isoenzymeM 3 that is expressedin nervous tissue. No robust findings suggest that these genes influence susceptibility to MS, but the results suggest that long-term prognosis is genetically influenced by the modulation of inflammatory cytokines and also by the ability to remove the toxic products of oxidative stress.
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Thummala, Suneel K. "Axon Initial Segment Stability in Multiple Sclerosis." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4038.

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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by inflammation and demyelination. In addition to these hallmark features, MS also presents with axonal pathology, which is likely responsible for the signs and symptoms of the disease. Although prominent in MS, axonal pathology is frequently considered a consequence of demyelination and not a primary event. This conclusion is consistent with demyelination inducing the loss of specific axonal domains, known as the nodes of Ranvier that are responsible for the propagation of action potentials along the axon. In contrast, we propose that axonal pathology associated with MS is a primary pathological event, independent of demyelination, and not a product of it. In support of our hypothesis, we have analyzed a different axonal domain known as the axon initial segment. Whereas a single axon has numerous nodes of Ranvier uniformly distributed along the axon, each axon contains only a single axon initial segment that is positioned immediately distal to the neuronal cell body. The axon initial segment is responsible for action potential generation and modulation, and hence is essential for normal neuronal function. Background studies conducted by our lab, employing a murine model of demyelination/remyelination, revealed no correlation between axon initial segment stability and myelin integrity. Here we investigate the fate of the axon initial segment in human multiple sclerosis. While not statistically significant, we provide data demonstrating an apparent 40% reduction in AIS numbers in MS. We further provide qualitative evidence that AIS integrity in MS is not dependent on myelination suggestive that axonal pathology may be a primary event in MS, independent of demyelination. Our current findings are intriguing, but unfortunately this study is underpowered, and more samples will be required to determine whether this apparent reduction is statistically significant.
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Iacobaeus, Ellen. "Establishment and applications of a multiple sclerosis biobank analysis of biomarkers and therapeutic complications in MS /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-811-2/.

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Books on the topic "Multiple Sclerosis (MS) sufferers"

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Radford, Inge. Action for MS care: A survey of multiple sclerosis sufferers and their carers in Northern Ireland. Belfast: Multiple Sclerosis Action Group (Action MS) (for) Department of Psychology, Queen's University of Belfast, 1987.

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Jones, Christian. MS: My story. St. Austell: Artshare South West (Cornwall) in conjunction with The Multiple Sclerosis Society of Great Britain and Northern Ireland (Mid-Cornwall Branch), 1989.

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Harrold, Kimberly. Sometimes MS is yucky. Chesterfield, Mo: Science & Humanities Press, 2005.

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McLaughlin, Chris. Multiple sclerosis: A positive approach to living with MS. London: Bloomsbury, 1997.

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Buh bye, MS: A true story. Santa Ana, Calif: Iridescent Orange Press, 2012.

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T, Fraser Robert, ed. The MS workbook: Living fully with multiple sclerosis. Oakland, CA: New Harbinger Publications, 2005.

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Devine, Monique. How to talk about ms with your children: A guide for parents. Dublin: Multiple Sclerosis Society of Ireland, 2003.

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Eerdekens, Jeanine. Chronische ziekte en rolverandering: Een sociologisch onderzoek bij MS-patiënten. Leuven: Acco, 1989.

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Romberg, Anders. MS ja liikunta: Iloa, elämänlaatua, toimintakykyä. Helsinki: Edita, 2005.

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Reed, Sue. Journey of a soul: In an MS body. Chicago, IL: Adams Press, 1990.

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Book chapters on the topic "Multiple Sclerosis (MS) sufferers"

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Bull, Paul J. "What Type of Person Suffers from MS?" In People with Multiple Sclerosis, 83–109. London: Palgrave Macmillan UK, 2015. http://dx.doi.org/10.1057/9781137457066_4.

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’t Hart, Bert A., S. Anwar Jagessar, Krista Haanstra, Yolanda S. Kap, and Jon D. Laman. "Modeling MS in Nonhuman Primates." In Multiple Sclerosis Immunology, 295–314. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7953-6_14.

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Gawlik, Barbara B., and David A. Hafler. "Regulatory T Cells in MS." In Multiple Sclerosis Immunology, 27–47. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7953-6_2.

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Freeman, Jennifer. "Rehabilitation in People with Progressive MS." In Progressive Multiple Sclerosis, 253–74. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65921-3_10.

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Bull, Paul J. "The Impact of MS." In People with Multiple Sclerosis, 159–212. London: Palgrave Macmillan UK, 2015. http://dx.doi.org/10.1057/9781137457066_6.

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Abrahamsson, Sofia, Miriam Mattoscio, and Paolo A. Muraro. "Haematopoietic Stem Cells for the Treatment of MS." In Multiple Sclerosis Immunology, 401–31. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7953-6_19.

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Hutchinson, Michael, and David P. J. Hunt. "Trials of Licenced RRMS DMTs in Progressive MS." In Progressive Multiple Sclerosis, 207–32. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65921-3_8.

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Nicholas, R. S., A. Nandoskar, M. Hutchinson, and T. Friede. "Trials of Novel Therapies Specifically for Progressive MS." In Progressive Multiple Sclerosis, 233–52. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65921-3_9.

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Broscheid, K. C., C. Dettmers, M. Behrens, W. Wolff, A. Peters, L. Schega, M. Vieten, and M. Jöbges. "Motor Performance Fatigability in MS." In Fatigue in Multiple Sclerosis, 59–72. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-13498-2_5.

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Khoshnam, Mohsen, and Mark Freedman. "Relapsing MS." In Multiple Sclerosis and CNS Inflammatory Disorders, 45–56. Chichester, UK: John Wiley & Sons, Ltd., 2014. http://dx.doi.org/10.1002/9781118298633.ch5.

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Conference papers on the topic "Multiple Sclerosis (MS) sufferers"

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Guerrera, Brittany, Samantha Farrow, Gloria Zeng, and Sally F. Shady. "Multiple Sclerosis Symptom Analyzer." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66217.

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Multiple Sclerosis (MS) is a chronic neurodegenerative disease of the central nervous system. MS is typically diagnosed between the ages of 20 and 40. There is no known cause of the disease and each individual experiences varying signs and symptoms depending on the severity of their disease. The most common symptoms include tremor, debilitated gait, visual impairment, or cognitive and emotional disturbances. Current methods used to treat MS include oral medication and surgical treatment. The issues with oral medication are the unwanted side effects to otherwise healthy tissue and the lack of patient adherence. Surgical treatment can be invasive and require longer recovery times. An alternate strategy to treat MS is by increasing the knowledge base of the practitioner to potentially treat specific symptoms. Currently, physicians use observations and MRI scans of the brain and spinal cord to help diagnose and track the progression of MS. There are several studies that analyze existing assistive technology to aid in the treatment of MS tremors. Most of these studies did not involve large test groups, therefore it is difficult to prove their validity. Additionally, none of the current devices are able to track symptoms while simultaneously creating medical history records. The goal of the design is to create a new device that will obtain the frequency and amplitude of tremors, while analyzing the effects of temperature and heart rate on the intensity of the tremor. With this data, the device will advance further MS research and lead to better diagnosis and treatment.
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Kaminska, M., DA Trojan, D. Da Costa, A. Bar-Or, A. Benedetti, Y. Lapierre, DL Arnold, et al. "Sleep-Disordered Breathing (SDB) and Fatigue in Multiple Sclerosis (MS)." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2128.

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Morrison, Cecily, Robert Corish, and Abigail Sellen. "ASSESS MS: Supporting the Clinical Assessment of Multiple Sclerosis using Kinect." In 8th International Conference on Pervasive Computing Technologies for Healthcare. ICST, 2014. http://dx.doi.org/10.4108/icst.pervasivehealth.2014.255429.

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Ekgi, Ziya, Muhammed Emin Ozean, Ayse Aralasmak, Emre Dandil, and Murat Cakiroglu. "Automatic computer-aided detection of Multiple Sclerosis (MS) lesions on MR images." In 2015 19th National Biomedical Engineering Meeting (BIYOMUT). IEEE, 2015. http://dx.doi.org/10.1109/biyomut.2015.7369443.

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Zhong, Yi, Shouliang Qi, Yan Kang, David Utriainen, Wei Feng, and E. Mark Haacke. "The average cerebral perfusion in patients with multiple sclerosis (MS) using MRI." In 2012 International Conference on Information and Automation (ICIA). IEEE, 2012. http://dx.doi.org/10.1109/icinfa.2012.6246865.

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Brussell, Edward M., and Mike Dixon. "Spatial and Temporal Deficits in Multiple Sclerosis." In Noninvasive Assessment of the Visual System. Washington, D.C.: Optica Publishing Group, 1987. http://dx.doi.org/10.1364/navs.1987.wb4.

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It is new well documented that an attenuation of spatial contrast sensitivity is to be expected in most multiple sclerosis (MS) patients (1-3). Further, it has been reported that patients contrast sensitivity functions can be influenced by modulating the grating in time as well as in space (4-7). The specific consequences of using flickering gratings, however, has been a matter of some conjecture. For example, Marx et al. (5) concluded that temporally modulating stimulus gratings causes a uniform reduction in contrast sensitivity across all spatial frequencies, while Medjbeur and Tulunay-Keesey (6) concluded that flickering the grating stimuli caused a number of distinct deficit patterns to emerge. Although these discrepancies could be due to the way in which the pathology manifested itself in the particular groups of patients sampled in these studies, they may also have been due to the uncontrolled and unknown response criteria that were adopted by the observers (8). An example of how this factor can influence the conclusions that are drawn has been offered by Brussell et al. (2). They observed similar contrast sensitivity deficit patterns in 15 MS patients for both flickering and non–flickering grating stimuli. The most parsimonious explanation of these data was that a single diseased pathway was carrying information about both the spatial and temporal characteristics of the stimulus. In addition to assessing contrast sensitivity, observers were also asked on each trial to state whether detection was based upon seeing a pattern or upon seeing flicker. A summary of these data indicated that the patients reported detecting patterns more often than controls. This additional information led to quite a different conclusion: the patients relied upon the output of a pattern mechanism more often than the controls because it was less impaired than a mechanism responsible for processing information about flicker.
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Amiri, Zahra, Yoones A. Sekhavat, and Sakineh Goljaryan. "A Framework for Rehabilitation Games to Improve Balance in People with Multiple Sclerosis (MS)." In 2018 2nd National and 1st International Digital Games Research Conference: Trends, Technologies, and Applications (DGRC). IEEE, 2018. http://dx.doi.org/10.1109/dgrc.2018.8712038.

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Li, Vivien, Ai-Lan Nguyen, Izanne Roos, Katherine Buzzard, Chris Dwyer, Mark Marriott, Mastura Monif, et al. "072 Impact of telehealth on multiple sclerosis (MS) outpatient clinics during the COVID-19 pandemic." In ANZAN Annual Scientific Meeting 2021 Abstracts. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/bmjno-2021-anzan.72.

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Heinonen, Tomi, Prasun Dastidar, Pertti Ryymin, Antti J. Lahtinen, Hannu Eskola, and Jaakko Malmivuo. "Quantitative assessment of MS plaques and brain atrophy in multiple sclerosis using semiautomatic segmentation method." In Medical Imaging 1997, edited by Eric A. Hoffman. SPIE, 1997. http://dx.doi.org/10.1117/12.274037.

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Zhang, Chaoyi, Yang Song, Sidong Liu, Scott Lill, Chenyu Wang, Zihao Tang, Yuyi You, et al. "MS-GAN: GAN-Based Semantic Segmentation of Multiple Sclerosis Lesions in Brain Magnetic Resonance Imaging." In 2018 Digital Image Computing: Techniques and Applications (DICTA). IEEE, 2018. http://dx.doi.org/10.1109/dicta.2018.8615771.

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Reports on the topic "Multiple Sclerosis (MS) sufferers"

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Timm, Eliane, Julia Vieregg, and Ursula Wolf. Movement based mindfulness therapies in patients with multiple sclerosis – a systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0102.

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Review question / Objective: The aim is to review the clinical benefits of mindful moving techniques for persons with multiple sclerosis. Condition being studied: Multiple sclerosis. Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (Gholamzad et al., 2019; Oh, Vidal-Jordana, & Montalban, 2018). It has shown to be increasing since 2013, and as of 2020 the estimated number of people with MS is 2.8 million worldwide (Walton et al., 2020). Due accumulation of relapses or gradual progression, disability from MS is worsening over time (Cameron & Nilsagard, 2018), which results in common symptoms like pain, imbalance, weakness, motor disorders, fatigue, depression, and more (Cameron & Nilsagard, 2018; Guicciardi et al., 2019).
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Nourbakhsh, Bardia, Nisha Revirajan, Bridget Morris, Christian Cordano, Jennifer Creasman, Michael Manguinao, Krysten Krysko, et al. Comparing Medicines to Help Patients with Multiple Sclerosis Feel Less Fatigued -- The TRIUMPHANT-MS Study. Patient-Centered Outcomes Research Institute (PCORI), June 2021. http://dx.doi.org/10.25302/06.2021.ms.151133689.

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Ehde, Dawn, Kevin Alschuler, Mark Sullivan, Ivan Molton, Marcia Ciol, Anna Lok, Charles Bombardier, et al. Does a Collaborative Care Program for Patients with Multiple Sclerosis Reduce Pain and Depression?—MS Care. Patient-Centered Outcomes Research Institute® (PCORI), July 2020. http://dx.doi.org/10.25302/06.2020.ih.13046379.

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Ehde, Dawn, Kevin Alschuler, Mark Sullivan, Ivan Molton, Marcia Ciol, Charles Bombardier, Kevin Gertz, et al. Does a Collaborative Care Program for Patients With Multiple Sclerosis Reduce Pain and Depression?—MS CARE. Patient-Centered Outcomes Research Institute (PCORI), April 2020. http://dx.doi.org/10.25302/04.2020.ih.13046379.

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Sriram, Subramaniam. MALDI/Mass Spectrometry of Normal Appearing and Dystrophic Axons in Spinal Cord of Multiple Sclerosis (MS). Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada582356.

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Sriram, Subramaniam. MALDI/Mass Spectrometry of Normal Appearing" and Dystrophic Axons in Spinal Cord of Multiple Sclerosis (MS)". Fort Belvoir, VA: Defense Technical Information Center, September 2013. http://dx.doi.org/10.21236/ada592436.

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zhang, linlin, xihua liu, yuxiao chen, qing wang, xinjie qu, xiaoming xi, haihao cao, limin wang, qiang chen, and hongyan bi. Effect of exercise training in multiple sclerosis: a protocol for systematic reviews and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0163.

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Review question / Objective: The main purpose of this scheme is to analyze and evaluate the effect on MS symptoms, quality of life, and improvement of mental state through strict literature aerobic training and the movement of resistance training, and to compare aerobic training, resistance training, and the combination of aerobic and resistance training through network meta-analysis, select the best scheme of intervention, and provide a reference for clinical and evidence-based guidelines. Information sources: Randomized controlled trials of exercise therapy for MS were searched in the PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wanfang Data Knowledge Service Platform, VIP, and CBM databases.
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Mahmoudi, Farhad, Mahtab Mokarram, Sadegh Sabouhi, Sara Hashemi, Parastoo Saberi, and Hadi Zamanian. Application of digital health for improving medication adherence in MS patients. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2021. http://dx.doi.org/10.37766/inplasy2021.10.0058.

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Review question / Objective: The aim of this study is to evaluate the efficacy of digital health interventions in monitoring and improving medication adherence in Multiple Sclerosis patients. Condition being studied: Multiple sclerosis (MS) is the most prevalent chronic inflammatory disease of the central nervous system (CNS), which leads to focal lesions in the white matter, characterized by selective primary demyelination with partial preservation of axons and reactive astrocytic gliosis. The disease is thought to be due to a complex interaction between different genetic and environmental factors. The prevalence of MS is rising all over the world, due on one hand to earlier diagnosis and prolonged survival, and on the other to a true increase in incidence of the disease. The diagnosis of MS remains clinical despite recent advances in diagnostics and relies on demonstrating dissemination in space and time while excluding alternative diagnoses.
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Wu, Xin. The efficacy and safety of anti-CD20 antibody treatments in relapsing multiple sclerosis: a systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0075.

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Review question / Objective: The objectives of this systematic review were to evaluate the efficacy and safety of the three existing anti-CD20 antibodies for the treatment of relapsing multiple sclerosis and to aid clinicians in choosing medications. Eligibility criteria: We set the inclusion criteria as follows: (1) study type: RCT; (2) language restriction: only available in English; (3) participants: patients ≥18 years of age diagnosed with relapsing MS, whether with a relapsing–remitting course or a secondary progressive course; (4) intervention: anti-CD20 antibody treatments including ocrelizumab, ofatumumab, rituximab, and corresponding control including placebo and active treatments; (5) outcomes: clinical outcomes including annualized rate of relapse (ARR), the number of patients free of relapse, and the number of patients with confirmed disease progression (CDP); magnetic resonance imaging(MRI) outcomes including gadolinium-enhancing lesion change in T1, change in the volume of lesions on T2, the number of patients with no new or newly enlarged lesions in T2 and the brain volume change (BVC); safety outcomes including adverse events (AEs) and serious adverse events (SAEs). Included RCTs were not requested to supply all the outcomes mentioned above. We set the exclusion criteria as follows: (1) study type: retrospective studies, cohort studies, case reviews and case reports; (2) patients diagnosed with primary progressive MS.
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