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Dissertations / Theses on the topic 'Multipotent mesenchymal stromall cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Grau, Vorster Marta. "Development and characterisation of advanced cell therapies based on multipotent mesenchymal stromal cells and virus-specific Tlymphocytes." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669379.

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El desenvolupament de noves teràpies s’està duent a terme arreu del món per poder fer front a les necessitats clíniques que actualment no disposen de tractament. En particular, els avenços en productes medicinals de teràpia avançada (ATMP) són una gran promesa per al tractament de malalties sense altres opcions terapèutiques. Tanmateix, els investigadors i les autoritats reguladores que implementen aquestes teràpies lluiten per estandarditzar tant els protocols com els productes finals. Entre els reptes s’inclouen l’elevada intervariabilitat de donants i mecanismes d’acció complexos. A més, és

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2

Bown, Andre B. J. "The Utilization of Multipotent Mesenchymal Stromal Cell Transplantation to Improve Fascia Repair." Youngstown State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1376390936.

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3

Assoni, Amanda Faria. "Caracterização do secretoma de células multipotentes mesenquimais estromais de diferentes fontes." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-18012016-104643/.

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Células multipotentes mesenquimais estromais (CTM) são células adultas multipotentes que podem ser isoladas a partir de diferentes tecidos e são capazes de atingir sítios danificados, exercer papéis na regeneração tecidual e modular a resposta imune. Estas células demonstraram resultados discrepantes em estudos in vivo dependentes de sua fonte de obtenção. Há na literatura hipóteses de que o mecanismo predominante pelo qual as CTMs atuam no reparo tecidual estaria relacionado à sua atividade parácrina, criando um microambiente com sinais tróficos. Nesse sentido, a avaliação do conteúdo do secr

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4

Hengartner, Nina-Emily [Verfasser]. "Immunomodulatory effects and migratory activity of multipotent mesenchymal stromal cells in the posttraumatic inflammatory response / Nina-Emily Hengartner." Ulm : Universität Ulm. Medizinische Fakultät, 2015. http://d-nb.info/1078957568/34.

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5

O'Brien, Etienne J. O. "An Evaluation of Whether Multipotent Mesenchymal Stromal Cells May Be Used to Improve the Quality of Tendon Repair." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501987.

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6

Sen, Kshama Shree [Verfasser]. "Mechanobiological effects of 3D-printed hydrogel-calcium phosphate composite materials on multipotent human mesenchymal stromal cells / Kshama Shree Sen." Aachen : Shaker, 2019. http://d-nb.info/118855266X/34.

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7

Aldridge, Andrew Robert. "Development of methods for the in-vitro assessment of the adipogenesis and immunogenicity of human multipotent mesenchymal stromal cells." Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/2391/.

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Adult mesenchymal stromal cells (MSCs) have enormous potential in tissue engineering and regenerative medicine applications. MSC have also been reported to be immune-privileged. The aim of this study was to develop methods to test two related hypotheses. Firstly, that MSCs will not directly stimulate allogeneic lymphocytes in classical lymphocyte proliferation assays carried out over 5-7 days due to lack of expression of immune-regulatory molecules (CD40, CD80, CD86 and MHC Class-II) but may be capable of the stimulation of allogeneic lymphocytes when cultured over extended time periods that a

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Souza, Lucas Eduardo Botelho de. "Células estromais mesenquimais multipotentes promovem a metástase de melanoma pela ativação da transição epitélio-mesenquimal." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-10012017-111618/.

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A interação entre células tumorais e células estromais tem um papel central na progressão neoplásica. As células estromais mesenquimais multipotentes (MSCs) podem se integrar ao microambiente tumoral onde modulam o crescimento dos tumores por meio de distintos mecanismos. Entretanto, pouco se sabe sobre o papel das MSCs na metástase, a principal causa de morte em pacientes com câncer. Utilizando um modelo de melanoma murino ortotópico, nós demonstramos que MSCs obtidas da medula óssea de camundongos (MO-MSCs) ocupam o nicho perivascular nos tumores primários e aumentam 2,5 vezes a incidência d

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9

Santos, Vanessa Tieko Marques dos. "Desenvolvimento de metodologia para produção de soro AB humano para suplementação de meio de cultura destinado ao cultivo de células mesenquimais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17156/tde-20072016-150857/.

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O crescente número de aplicações clínicas envolvendo células mesenquimais estromais multipotentes (CMMs) gera a necessidade da produção em larga escala destas células com adequada qualidade terapêutica. As CMMs são geradas atualmente através de culturas aderentes na presença de soro fetal bovino (SFB). Entretanto, apesar da eficiência na promoção do crescimento celular, o uso de SFB não é isento de desvantagens e riscos. Além do alto custo, sua utilização pode gerar risco de contaminação do produto final com agentes adventícios como vírus e príons. Por outro lado, a sua variabilidade em difere

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10

Braun, Julian [Verfasser], Andreas [Akademischer Betreuer] Thiel, Jun [Akademischer Betreuer] Dong, Leif-Andreas [Akademischer Betreuer] Garbe, and Andreas [Akademischer Betreuer] Kurtz. "Analysis of the derivation phase of human adipose tissue-derived multipotent mesenchymal stromal cells / Julian Braun. Gutachter: Leif-Andreas Garbe ; Andreas Kurtz. Betreuer: Andreas Thiel ; Jun Dong." Berlin : Technische Universität Berlin, 2013. http://d-nb.info/1065664672/34.

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11

Oliveira, Gislane Lelis Vilela de. "Análise da expressão gênica por microarrays de células-tronco hematopoéticas e mesenquimais de pacientes com esclerose múltipla." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-18032013-135704/.

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As células-tronco hematopoéticas (CTHs) e estromais mesenquimais multipotentes (CTMs) isoladas da medula óssea vêm sendo utilizadas como fonte autóloga no tratamento de doenças autoimunes, como a esclerose múltipla (EM). As CTHs dão origem a todas as células dos sistemas hematopoético e imunológico e as CTMs possuem propriedades imunomoduladoras pela liberação de fatores solúveis e interação célula-célula. Existem trabalhos que sugerem que as doenças autoimunes sejam provenientes de defeitos intrínsecos nas células-tronco precursoras da medula óssea. Com o intuito de avaliar se as CTHs e CTMs

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12

Romero, Jenny Manzano. "Análise das características biológicas das células estromais mesenquimais multipotentes obtidas de diferentes regiões anatômicas de pacientes com Pseudoartrose Congênita da Tíbia." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17153/tde-08012019-153231/.

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A Pseudoartrose Congênita da Tíbia (PCT) é uma das doenças mais desafiantes da ortopedia pediátrica pela dificuldade em obter a união óssea e, quando esta ocorre, em mantê-la. É uma doença muito rara, difícil de tratar devido à sua falta de conhecimento sobre a patogênese. As Células estromais mesenquimais multipotentes (CMM) podem desempenhar um papel na patogênese do PCT, possivelmente devido à falha da diferenciação osteogênica. O estudo das CMM pode ajudar a compreender a patogênese da doença e desenvolver novas estratégias terapêuticas baseados no uso desta célula no futuro próximo. Frent

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13

Päbst, Felicitas Miriam Thekla. "Oberflächenentigen- und Sehnenmarkerexpression equiner multipotenter mesenchymaler Stromazellen." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-202786.

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1. Einleitung Multipotente mesenchymale Stromazellen (MSC) stellen eine interessante Therapieoption in der regenerativen Medizin verschiedener Erkrankungen dar. Aufgrund ihrer Herkunft aus mesodermalem Gewebe ist ihr Einsatz in der Therapie von Sehnenerkrankungen als günstig anzusehen, wo sie bei Pferden bereits erfolgreich verwendet werden. Da dieser Erkrankungskomplex mit degenerativen Veränderungen der Achillessehne des Menschen vergleichbar ist, wäre eine Translation der gewonnenen Ergebnisse in die Humanmedizin wünschenswert. Die zugrunde liegenden Wirkmechanismen bei der Sehnenregenerati

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14

Queiroz, Diana Leocata de. "Transplante intratecal de células estromais mesenquimais multipotentes em equinos através do espaço intervertebral C1-C2." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152240.

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Submitted by Diana Leocata de Queiroz null (diana_leocata@hotmail.com) on 2017-12-04T13:26:05Z No. of bitstreams: 1 TRANSPLANTE INTRATECAL DE CÉLULAS ESTROMAIS MESENQUIMAIS MULTIPOTENTES EM EQUINOS ATRAVÉS DO ESPAÇO INTERVERTEBRAL C1-C2 finalf.pdf: 1646738 bytes, checksum: b542c7fc14354a10598a5cdea4680f6b (MD5)<br>Submitted by Diana Leocata de Queiroz null (diana_leocata@hotmail.com) on 2017-12-04T14:43:24Z No. of bitstreams: 1 TRANSPLANTE INTRATECAL DE CÉLULAS ESTROMAIS MESENQUIMAIS MULTIPOTENTES EM EQUINOS ATRAVÉS DO ESPAÇO INTERVERTEBRAL C1-C2 finalf.pdf: 1646738 bytes, checksum: b542c7

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Angstmann, Michael [Verfasser], and Stefan [Akademischer Betreuer] Wölfl. "Characterization of cell-matrix interactions during multipotent mesenchymal stromal cell (MSC) differentiation / Michael Angstmann ; Betreuer: Stefan Wölfl." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/1179230140/34.

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16

Li, Yueying. "Vieillissement des cellules stromales mésenchymateuses de la moelle osseuse : implications en médecine régénérative." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0099/document.

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Grâce à leurs propriétés de différenciation, les cellules stromales mésenchymateuses (CSM) constituent aujourd’hui un outil en médecine régénérative. La moelle osseuse reste une des plus utilisées. Une diminution de la capacité de prolifération et de différenciation des CSM-MO, au cours des passages, a été montrée. En parallèle, certaines études montrent que l'impact de l'âge du donneur sur les propriétés de CSM-MO reste encore controversé. Le but de notre étude était de mieux comprendre l'effet de l'âge du donneur mais aussi des passages en culture sur la capacité de prolifération et de diffé

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17

Mizukami, Amanda. "Expansão in vitro de células estromais mesenquimais e caracterização do secretoma: aplicações terapêuticas e biotecnológicas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17153/tde-06012017-103806/.

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As células estromais mesenquimais (CMMs) se tornaram de grande interesse para a terapia celular devido ao seu potencial de se diferenciar e reconstituir tecidos especializados. Mais recentemente, este interesse tem aumentado significativamente devido à descoberta de que as CMMs são capazes de secretar uma infinidade de mediadores para estimular a regeneração in situ de tecidos lesados. Dessa forma, CMMs podem ser consideradas tanto como um produto terapêutico em si, quanto uma biofábrica de diversas proteínas relevantes do ponto de vista terapêutico. Para atender a estas crescentes demandas, a

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18

Sethia, Pavan P. "Development and Commercialization of Menstrual Blood Stem Cells Banking." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1303759438.

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Zampar, Antonio Gustavo. "Análise de células mesenquimais multipotentes derivadas de diferentes áreas doadoras de tecido adiposo e sua influência sobre fibroblastos in vitro." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-08012019-154153/.

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A cicatrização de feridas crônicas e de defeitos complexos representam desafios para a cirurgia plástica reconstrutiva. Novos tratamentos emergiram com a utilização de células tronco mesenquimais, com especial interesse para as derivadas de tecido adiposo (CTMs-TA), por possuir algumas vantagens em relação às derivadas da medula óssea. Algumas doenças poderiam se beneficiar com o uso das CTMs-TA, em particular, as feridas de pacientes portadores de anemia falciforme que ainda representam um desafio terapêutico. Neste estudo, investigou-se a existência de possíveis áreas doadoras preferenciais

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20

Pimentel, Thaís Valéria Costa de Andrade. "Influência de fatores de crescimento pró-angiogênicos na manutenção das características de células progenitoras mesenquimais derivadas do tecido adiposo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17153/tde-02022016-100332/.

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A manutenção do estado progenitor durante o cultivo de células mesenquimais progenitoras derivadas do tecido adiposo (MSCs-TA), caracterizado pelo potencial de diferenciação e da capacidade de autorrenovação, é atualmente um dos maiores desafios da terapia celular. Sabendo da influência da angiogênese no desenvolvimento de tecidos de origem mesenquimal, avaliamos se um ambiente pro-angiogênico mimetizado em cultura forneceria condições para manutenção de um estado progenitor durante o processo de expansão celular. Utilizando como modelo de um ambiente pró-angiogênico o cultivo no meio EGM-2, o

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Silva, Teresa Maria Pereira da. "Multipotent mesenchymal stromal cells for Machado Joseph disease therapy." Master's thesis, 2014. http://hdl.handle.net/10316/30598.

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Dissertação de mestrado em Biotecnologia Farmacêutica, apresentada à Faculdade de Farmácia da Universidade de Coimbra.<br>Machado Joseph disease or Spinocerebellar ataxia type 3 is the most common SCA worldwide, caused by an expanded CAG repeat in the MJD1 gene, which translates into a polyQ tract within the ataxin-3 protein. Currently, there is no therapy able to modify or delay disease progression. Multipotent mesenchymal stromal cells (MSC) are extremely promising tools for therapy of neurodegenerative disorders and, more recently, this therapeutic approach became motif of interest wit

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Silva, Ângela Maresch Rosa da. "Células mesenquimatosas e o envelhecimento." Master's thesis, 2015. http://hdl.handle.net/10316/30497.

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Trabalho final de mestrado integrado em Medicina, apresentado à Faculdade de Medicina da Universidade de Coimbra.<br>O envelhecimento demográfico resulta da diminuição da taxa de natalidade a par do aumento da esperança média de vida. Evidentemente, a situação sem precedentes que estamos a viver presentemente representa um desafio no sentido de atenuar a morbilidade nos idosos, retardando, tratando ou curando as doenças sempre que possível. Uma das respostas é a terapia celular, particularmente a baseada em células estaminais mesenquimatosas (MSCs) – dada a sua acessibilidade, facilidade de cu

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23

Barata, João Carlos Versos Varanda. "Unravelling the players of Mesenchymal Stromal Cells' Neuroprotective Effect in Machado-Joseph Disease." Master's thesis, 2017. http://hdl.handle.net/10316/82985.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is a neurodegenerative disorder caused by an abnormally expanded number of CAG repeats in the gene codifying the protein ataxin-3. This mutation leads to dysfunction of several cellular mechanisms, including autophagy, and ends with neuronal death, mainly in the cerebellum, striatum and brain stem. Currently, there is no cure or therapy for this fatal disorder. Multipotent mesenchymal stromal cells (MSCs) h

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"Multipotent mesenchymal stromal cells (MSCs) and apolipoprotein E secretion: A potential treatment for atherosclerosis and Alzheimer's disease." TULANE UNIVERSITY, 2009. http://pqdtopen.proquest.com/#viewpdf?dispub=3349969.

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25

Chen, Wen Li Kelly. "Matrix Mechanical and Biochemical Regulation of Multipotent Stromal Cell Osteogenesis." Thesis, 2013. http://hdl.handle.net/1807/43499.

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Biochemical and mechanical properties of the extracellular matrix (ECM) are known to independently influence cell function. Given the complexity of cellular responses, I hypothesized that the integration of multiple matrix factors as opposed to their individual contribution is key to understanding and controlling cell function. The objective of this thesis was to systematically investigate matrix biochemical and mechanical regulation of multipotent stromal cell (MSC) osteogenesis. First, I demonstrated that substrate stiffness-dependent MSC spreading, proliferation and osteogenic response were

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Päbst, Felicitas Miriam Thekla. "Oberflächenentigen- und Sehnenmarkerexpression equiner multipotenter mesenchymaler Stromazellen." Doctoral thesis, 2015. https://ul.qucosa.de/id/qucosa%3A14703.

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1. Einleitung Multipotente mesenchymale Stromazellen (MSC) stellen eine interessante Therapieoption in der regenerativen Medizin verschiedener Erkrankungen dar. Aufgrund ihrer Herkunft aus mesodermalem Gewebe ist ihr Einsatz in der Therapie von Sehnenerkrankungen als günstig anzusehen, wo sie bei Pferden bereits erfolgreich verwendet werden. Da dieser Erkrankungskomplex mit degenerativen Veränderungen der Achillessehne des Menschen vergleichbar ist, wäre eine Translation der gewonnenen Ergebnisse in die Humanmedizin wünschenswert. Die zugrunde liegenden Wirkmechanismen bei der Sehnenregenerati

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Hsu, Chuen-Hau, and 許淳皓. "In vitro differentiation and cultivation of hepatocytes using human marrow-derived multipotent mesenchymal stem cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/16931108896312264099.

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碩士<br>國立東華大學<br>生物技術研究所<br>92<br>To establish a high-density functional hepatic cell culture, the in vitro differentiation and cultivation of hepatic cells generated from bone-marrow derived multipotent mesenchymal stem cells (BMMSCs) were investigated in this study. Conditions for hepatic differentiation and maintenance were tested. It was found that human hepatocyte growth factor with a concentration higher than 10 ng/ml could result in the differentiation of BMMSCs into hepatic cells which expressed hepatocyte specific genes and secreted albumin and urea as well. The gene expression patter

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Pytlík, Robert. "Lidské multipotentní mezenchymové stromální buňky - kostní diferenciace a podpora krvetvorby." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-372372.

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Human mesenchymal stromal cells (hMSC) are adult stem or progenitor cells, which physiological role is reparation of damaged tissues. This is achieved mostly by secretion of trophic, angiopoietic and immunomodulatory factors. Beside this, hMSC have potential to differentiate in vitro into specialized cells, especially of the mesodermal lineages. Human MSC also significantly support hematopoiesis in hematopoietic niche. This knowledge raised high hopes for therapeutic use of hMSC, especially in regenerative medicine and treatment of autoimmune diseases, including graft versus host disease (GvHD

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Chen, Yung-Pin, and 陳永斌. "Transplantation of human multipotent mesenchymal stem cells is beneficial to the 6-OHDA induced hemiparkinsonian rats." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/71819361280754981582.

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碩士<br>國立東華大學<br>生物技術研究所<br>92<br>Parkinson’s disease is a degenerative disorder characterized by a loss of dopamine neurons. Since the multipotent mesenchymal stem cells (MSCs) derived from either human bone marrow or umbilical cord blood have been shown to have the potential in neurogenesis in vitro, the objective of this study is to investigate the feasibility of using these cells as the donor source for the cell therapy of Parkinson’s disease by a hemiparkinsonian rat model. The unilateral stereotaxic injections of 6-hydroxydopamine into the median forebrain bundle of male Sprague-Dawley

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"The therapeutic potential of human mesenchymal/multipotent stem/progenitor cells in the striatum of Huntington diseased mice." Tulane University, 2008.

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Human Mesenchymal Stern/Multipotent Progenitor Cells (hMSCs have previously been shown to potentiate neurogenesis after implantation into a neurogenic niche of the adult mouse brain1. This study determined whether or not this effect will persist in a disease model affecting the Central Nervous System (CNS), specifically in N171-82Q Huntington's disease (HD) mice. Twenty four hours after implantation into the striatum, only approximately 15% of the grafted hMSCs remained. Only roughly 5% of the grafted cells survived to 5 days and no intact cells were detected by 15 days post-implantation. Conv

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Aziz, Arif. "Regulation of multipotent mesenchymal cell differentiation into skeletal muscle by AP-1 and TGF-beta signalling components /." 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:NR51670.

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Thesis (Ph.D.)--York University, 2009. Graduate Programme in Biology.<br>Typescript. Includes bibliographical references (leaves 275-298). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:NR51670

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Chang, Yu-Jen, and 張育甄. "Characterization of Multipotent Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord Blood, Amniotic Fluid and Amniotic Membrane." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/84214814075223769489.

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博士<br>國立交通大學<br>生物科技系所<br>94<br>Abstract During human entire lifespan, from fetus to adult, mesenchymal stem cells (MSCs) proliferate and differentiate into mesenchyme-lineage tissues. Bone marrow and umbilical cord blood are reported to be the main sources of MSCs and have been proposed for possible clinical applications. This study evaluates the tendency in bone marrow-derived MSCs (bmMSCs) and cord blood-derived MSCs (cbMSCs) by in vitro induction and quantification of their characteristics. Results indicated that cbMSCs had a significantly stronger osteogenic potential but less capacity i

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Sun, Li-Yi, and 孫立易. "The effect of pulsed electromagnetic fields on the proliferation and differentiation of human bone marrow multipotent mesenchymal stem cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/19012778716327742215.

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碩士<br>國立東華大學<br>生物技術研究所<br>92<br>Pulsed electromagnetic fields (PEMFs) have been clinically employed in slowing down the osteoporosis and accelerating the healing of bone fractures for many years. However, its action mechanisms on cellular level are still not fully understood. The effects of PEMFs on mesenchymal stem cells, which are the origin of osteoblast cells, are also seldom reported. The objective of this study is to investigate the effect of PEMFs on the proliferation and differentiation of multipotent human bone marrow mesenchymal stem cells (BMMSCs). BMMSCs were obtained by negativ

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Silkstone, David. "Age Related Tissue Fibrosis During Fracture Repair Is Mediated by Wnt/β-catenin Signaling". Thesis, 2010. http://hdl.handle.net/1807/25802.

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The regenerative potential of tissue injury declines with age. Recently, a significant role for Wnt/β-catenin signaling has been shown in tissue specific stem cell aging, leading to increased tissue fibrosis. Wnt/β-catenin signaling regulates the differentiation of multipotent mesenchymal stem cells into osteoblasts during fracture repair. We investigated the potential role of dysregulated Wnt/β-catenin signaling in delayed fracture union and tissue fibrosis in the elderly. Old mice displayed increased total β-catenin protein levels at 4 and 7 days post-fracture and tissue fibrosis at 14 a

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