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Journal articles on the topic 'Multisteps organic synthesis'

Author: Grafiati

Published: 25 January 2025

Last updated: 31 July 2025

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1

Huang, Jianhui, Caifeng Li, Liu Liu, and Xuegang Fu. "Norbornene in Organic Synthesis." Synthesis 50, no. 15 (2018): 2799–823. http://dx.doi.org/10.1055/s-0037-1610143.

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The norbornene skeleton possesses an alkene functionality with a fixed conformation, and represents unique reactivity. The use of norbornene and analogues as substrates is overviewed; reactivities are discussed as well as the role of norbornenes as ligands assisting modern organic transformations.1 Introduction2 Synthesis of Substituted Norbornenes2.1 Preparation of Functionalized Norbornenes by Deprotonation and Substitution Reactions2.2 Preparation of Functionalized Norbornenes under Palladium-Catalyzed Reaction Conditions2.3 Alkylation of Norbornene2.4 Multistep Synthesis3 Synthesis of Sub

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2

Ren, Yun-Lai, Jianji Wang, Xinzhe Tian, Fangping Ren, Xinqiang Cheng, and Shuang Zhao. "Direct Conversion of Benzyl Ethers into Aryl Nitriles." Synlett 29, no. 18 (2018): 2444–48. http://dx.doi.org/10.1055/s-0037-1611062.

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A direct method was developed for the conversion of benzyl ethers into aryl nitriles by using NH4OAc as the nitrogen source and oxygen as the terminal oxidant with catalysis by TEMPO/HNO3; the method is valuable for both the synthesis of aromatic nitriles and for the deprotection of ether-protected hydroxy groups to form nitrile groups in multistep organic syntheses.

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Sakai, Naomi, and Stefan Matile. "Multistep organic synthesis of modular photosystems." Beilstein Journal of Organic Chemistry 8 (June 19, 2012): 897–904. http://dx.doi.org/10.3762/bjoc.8.102.

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Quite extensive synthetic achievements vanish in the online supporting information of publications on functional systems. Underappreciated, their value is recognized by experts only. As an example, we here focus in on the recent synthesis of multicomponent photosystems with antiparallel charge-transfer cascades in co-axial hole- and electron-transporting channels. The synthetic steps are described one-by-one, starting with commercial starting materials and moving on to key intermediates, such as asparagusic acid, an intriguing natural product, as well as diphosphonate “feet”, and panchromatic

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4

Glaser, John A. "Multistep organic synthesis using flow chemistry." Clean Technologies and Environmental Policy 15, no. 2 (2013): 205–11. http://dx.doi.org/10.1007/s10098-013-0599-1.

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5

Shukla, Chinmay A., and Amol A. Kulkarni. "Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic." Beilstein Journal of Organic Chemistry 13 (May 19, 2017): 960–87. http://dx.doi.org/10.3762/bjoc.13.97.

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The implementation of automation in the multistep flow synthesis is essential for transforming laboratory-scale chemistry into a reliable industrial process. In this review, we briefly introduce the role of automation based on its application in synthesis viz. auto sampling and inline monitoring, optimization and process control. Subsequently, we have critically reviewed a few multistep flow synthesis and suggested a possible control strategy to be implemented so that it helps to reliably transfer the laboratory-scale synthesis strategy to a pilot scale at its optimum conditions. Due to the va

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6

Salame, Issa I., Pauline Casino, and Natasha Hodges. "Examining Challenges that Students Face in Learning Organic Chemistry Synthesis." International Journal of Chemistry Education Research 3, no. 3 (2020): 1–9. http://dx.doi.org/10.20885/ijcer.vol4.iss1.art1.

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Organic chemistry is the offered after general chemistry and is the course that many find it challenging and difficult. Synthesis is first introduced in organic chemistry I course and is widely considered as one of the topics in which students struggle with and is evident in their performance in the topic. Our method of data collection is a Likert-type and open-ended questionnaire that was distributed at the end organic chemistry I course in an anonymous fashion. The collected data enabled us to examine the challenges students face in learning organic chemistry synthesis. Our findings support

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7

Ortega, Pedro, Miguel Guzmán, and Leonel Vera. "Useful Spreadsheet for Updating Multistep Organic Synthesis." Journal of Chemical Education 73, no. 8 (1996): 726. http://dx.doi.org/10.1021/ed073p726.

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8

Saito, Hayate, Jun Shimokawa, and Hideki Yorimitsu. "The dioxasilepanyl group as a versatile organometallic unit: studies on stability, reactivity, and utility." Chemical Science 12, no. 27 (2021): 9546–55. http://dx.doi.org/10.1039/d1sc02083h.

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9

Azzena, Ugo, Massimo Carraro, Gloria Modugno, Luisa Pisano, and Luigi Urtis. "Heterogeneous acidic catalysts for the tetrahydropyranylation of alcohols and phenols in green ethereal solvents." Beilstein Journal of Organic Chemistry 14 (July 3, 2018): 1655–59. http://dx.doi.org/10.3762/bjoc.14.141.

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The application of heterogeneous catalysis and green solvents to the set up of widely employed reactions is a challenge in contemporary organic chemistry. We applied such an approach to the synthesis and further conversion of tetrahydropyranyl ethers, an important class of compounds widely employed in multistep syntheses. Several alcohols and phenols were almost quantitatively converted into the corresponding tetrahydropyranyl ethers in cyclopentyl methyl ether or 2-methyltetrahydrofuran employing NH4HSO4 supported on SiO2 as a recyclable acidic catalyst. Easy work up of the reaction mixtures

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10

Sharma, Mrityunjay K., Roopashri B. Acharya, Chinmay A. Shukla, and Amol A. Kulkarni. "Assessing the possibilities of designing a unified multistep continuous flow synthesis platform." Beilstein Journal of Organic Chemistry 14 (July 26, 2018): 1917–36. http://dx.doi.org/10.3762/bjoc.14.166.

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The multistep flow synthesis of complex molecules has gained momentum over the last few years. A wide range of reaction types and conditions have been integrated seamlessly on a single platform including in-line separation as well as monitoring. Beyond merely getting considered as ‘flow version’ of conventional ‘one-pot synthesis’, multistep flow synthesis has become the next generation tool for creating libraries of new molecules. Here we give a more ‘engineering’ look at the possibility of developing a ‘unified multistep flow synthesis platform’. A detailed analysis of various scenarios is p

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11

Graham, Kate J., Chris P. Schaller, Brian J. Johnson, and John B. Klassen. "Student-Designed Multistep Synthesis Projects in Organic Chemistry." Chemical Educator 7, no. 6 (2002): 376–78. http://dx.doi.org/10.1007/s00897020612a.

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12

Herath, Ananda, and Nicholas D. P. Cosford. "Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction." Beilstein Journal of Organic Chemistry 13 (February 7, 2017): 239–46. http://dx.doi.org/10.3762/bjoc.13.26.

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A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor, multistep continuous-flow system without isolation of intermediates. This continuous-flow method was successfully combined with a single-step liquid–liquid microextraction unit to remove high boiling point polar solvents and impurities and provides the target compounds in high purity with excellent overall yields.

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13

Yang, Yang, Xiao Hui Wang, and Long Tu Li. "Synthesis of TiO₂ Nanotube Arrays Through Multistep Anodization." Key Engineering Materials 368-372 (February 2008): 526–28. http://dx.doi.org/10.4028/www.scientific.net/kem.368-372.526.

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Multistep electrochemical anodization is an electrochemical experiment orderly conducting in different electrolytes. In this paper, TiO2 nanotube arrays have been firstly anodic grown in aqueous electrolyte (H3PO4/HF) and later anodic grown in organic electrolyte (glycerol/NH4F). Compared with separately anodizing in aqueous and organic electrolyte, the morphology of the resulting nanotube arrays can be optimized. SEM images showed that the obtained nanotubes have a length of more than 2 μm and single-pore diameter ranging from 120 to 150 nm. The current work indicates that the multistep elect

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14

Lyle, Steven J., Thomas M. Osborn Popp, Peter J. Waller, Xiaokun Pei, Jeffrey A. Reimer, and Omar M. Yaghi. "Multistep Solid-State Organic Synthesis of Carbamate-Linked Covalent Organic Frameworks." Journal of the American Chemical Society 141, no. 28 (2019): 11253–58. http://dx.doi.org/10.1021/jacs.9b04731.

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15

McKee, Mireya L., Phillip J. Milnes, Jonathan Bath, Eugen Stulz, Rachel K. O’Reilly, and Andrew J. Turberfield. "Programmable One-Pot Multistep Organic Synthesis Using DNA Junctions." Journal of the American Chemical Society 134, no. 3 (2012): 1446–49. http://dx.doi.org/10.1021/ja2101196.

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16

Sharma, Nisha, Rashmi Pundeer, and Om Prakash. "8-Aryloct-7-en-2,4,6-triones as Useful Precursors for the Regioselective Synthesis of Some New 2-Methyl-5-styryl-7-thioxo-6,7-dihydropyrazolo[1,5-c]pyrimidines." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 33, no. 03 (2023): 355. http://dx.doi.org/10.59467/ijhc.2023.33.355.

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Dehydroacetic acid, commonly abbreviated as DHA, and its derivatives have been extensively used as important intermediates in organic synthesis particularly for the synthesis of heterocyclic compounds. The reaction of 8-aryloct-7-en-2,4,6-triones (DHA-triones, readily prepared from commercially available DHA by the use of a multistep procedure) with thiosemicarbazide led the formation of some new 2-methyl-5-styryl-7-thioxo-6,7-dihydropyrazolo[1,5-c] pyrimidines.

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17

Gramage-Doria, Rafael, Yu-Chao Yuan, and Christian Bruneau. "Merging Transition-Metal Catalysis with Phthalimides: A New Entry to Useful Building Blocks." Synthesis 50, no. 21 (2018): 4216–28. http://dx.doi.org/10.1055/s-0037-1610282.

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Phthalimides have found their main application in organic synthesis as protecting groups for primary amines during the multistep synthesis of biologically relevant targets. On the other hand, phthalimide functionalization is rather challenging and it is traditionally associated with the use of over-stoichiometric amounts of environmentally hazardous reagents. In this short review, we describe and discuss how, in the last decades, transition-metal catalysts have provided useful organic building blocks after selective transformation of the phthalimide skeleton in a more efficient and sustainable

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18

Balasubramaniam, Sivaraman, Sajith Vijayan, Liam V. Goldman, et al. "Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition." Beilstein Journal of Organic Chemistry 16 (April 7, 2020): 628–37. http://dx.doi.org/10.3762/bjoc.16.59.

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Guided by computational analysis, herein we report the design, synthesis and evaluation of four novel diazine-based histone deacetylase inhibitors (HDACis). The targets of interest (TOI) are analogues of panobinostat, one of the most potent and versatile HDACi reported. By simply replacing the phenyl core of panobinostat with that of a diazine derivative, docking studies against HDAC2 and HDAC8 revealed that the four analogues exhibit inhibition activities comparable to that of panobinostat. Multistep syntheses afforded the visualized targets TOI1, TOI2, TOI3-rev and TOI4 whose biological eval

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19

Yang, Jye-Shane, Hsin-Hau Huang, and Shih-Hsun Lin. "Facile Multistep Synthesis of Isotruxene and Isotruxenone†." Journal of Organic Chemistry 74, no. 10 (2009): 3974–77. http://dx.doi.org/10.1021/jo900299q.

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20

Johnston, Meghan R., Alexandros Makriyannis, Kyle M. Whitten, Olivia C. Drew, and Fiona A. Best. "Biocatalyzed Regioselective Synthesis in Undergraduate Organic Laboratories: Multistep Synthesis of 2-Arachidonoylglycerol." Journal of Chemical Education 93, no. 12 (2016): 2080–83. http://dx.doi.org/10.1021/acs.jchemed.6b00225.

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21

Sun, Xiao Xia, Xiao Xiao Zhuang та Yu Hu. "Synthesis, Characterization of Novel π-Conjugated Polymers Acceptor 5,6-bis(heptyloxy)benzo[c][1,2,5]thiadiazole". Advanced Materials Research 781-784 (вересень 2013): 444–47. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.444.

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Monomers based on 2,1,3-benzothiadiazole bearing solubilizing side chains have been synthesized in high yields over four steps from readily available starting materials. A multistep synthesis of the electron-poor 5,6-bis (heptyloxy) benzo [[1,2,thiadiazole are presented. The new deficient acceptor has good solubility in organic solvents to permit an appropriate coating process.

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22

Sun, Xiao Xia, Xiao Long Lei, Chun Hua Qi, and Yu Hu. "The New Synthesis of 4,7-dithienyl[ 2,1,3]-benzoselenadiazole." Advanced Materials Research 781-784 (September 2013): 440–43. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.440.

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Heterocyclic monomers based on benzo [[1,2,thiadizole bearing solubilizing side chains have been synthesized in high yields over four steps from readily available starting materials. A multistep synthesis of the electron-poor 4,7-di (thiophen-2-yl) benzo [[1,2,selenadizole are presented. The new dificient acceptor has good solubility in organic aolvents to permit an appropriate coating process.

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23

Peters, Dennis G., and Chang Ji. "A Multistep Synthesis for an Advanced Undergraduate Organic Chemistry Laboratory." Journal of Chemical Education 83, no. 2 (2006): 290. http://dx.doi.org/10.1021/ed083p290.

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24

Wegner, Jens, Sascha Ceylan, and Andreas Kirschning. "Flow Chemistry – A Key Enabling Technology for (Multistep) Organic Synthesis." Advanced Synthesis & Catalysis 354, no. 1 (2012): 17–57. http://dx.doi.org/10.1002/adsc.201100584.

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25

Wu, Shuke, and Zhi Li. "Whole-Cell Cascade Biotransformations for One-Pot Multistep Organic Synthesis." ChemCatChem 10, no. 10 (2018): 2164–78. http://dx.doi.org/10.1002/cctc.201701669.

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26

Ardila-Fierro, Karen J., Andrij Pich, Marc Spehr, José G. Hernández, and Carsten Bolm. "Synthesis of acylglycerol derivatives by mechanochemistry." Beilstein Journal of Organic Chemistry 15 (March 29, 2019): 811–17. http://dx.doi.org/10.3762/bjoc.15.78.

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In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.

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27

Sun, Xiao Xia, Xiao Xiao Zhuang, Ying Chun Li, Xi Mei Liu, and Ya Zhou Lou. "Synthesis of [6,7]-Dihydro-[1,4]-Dioxino-[2,3-f][2,1,3]-Benzothiadiazole: A Novel Building Block for Electron-Poor Conjugated Polymers"." Advanced Materials Research 284-286 (July 2011): 601–6. http://dx.doi.org/10.4028/www.scientific.net/amr.284-286.601.

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Heterocyclic monomers based on 2,1,3-benzothiadiazole bearing solubilizing side chains have been synthesized in high yields over four steps from readily available starting materials. A multistep synthesis of the electron-poor 6, 7-dihydro-1, 4-dioxino-[2, 3-f][2,1,3]-benzothiadiazole are presented. The new dificient acceptor has good solubility in organic aolvents to permit an appropriate coating process.

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28

Howard, Joseph L., William Nicholson, Yerbol Sagatov, and Duncan L. Browne. "One-pot multistep mechanochemical synthesis of fluorinated pyrazolones." Beilstein Journal of Organic Chemistry 13 (September 14, 2017): 1950–56. http://dx.doi.org/10.3762/bjoc.13.189.

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Solventless mechanochemical synthesis represents a technique with improved sustainability metrics compared to solvent-based processes. Herein, we describe a methodical process to run one solventless reaction directly into another through multistep mechanochemistry, effectively amplifying the solvent savings. The approach has to consider the solid form of the materials and compatibility of any auxiliary used. This has culminated in the development of a two-step, one-jar protocol for heterocycle formation and subsequent fluorination that has been successfully applied across a range of substrates

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29

McQuade, D. Tyler, and Peter H. Seeberger. "Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis." Journal of Organic Chemistry 78, no. 13 (2013): 6384–89. http://dx.doi.org/10.1021/jo400583m.

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30

Damha, Masad José, Nassim Usman, and Kelvin Kenneth Ogilvie. "Solution and solid phase chemical synthesis of arabinonucleotides." Canadian Journal of Chemistry 67, no. 5 (1989): 831–39. http://dx.doi.org/10.1139/v89-129.

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A fast and convenient procedure for the chemical synthesis of arabinonucleotides, which eliminates the multistep protection of the arabinonucleoside building blocks, is described. The results of these studies were successfully applied to the automated chemical synthesis of the hexanucleotide 5′-aUpaApaUpaApaUpaA-3′. Both solution and solid phase phosphite triester procedures are described. Keywords: arabinonucleotides, arabinophosphoramidites, automated chemical synthesis, protected arabinonucleosides.

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31

Pfund, Emmanuel, and Thierry Lequeux. "Synthesis of Fluoropyrrolidines and (Fluoroalkyl)pyrrolidines." Synthesis 49, no. 17 (2017): 3848–62. http://dx.doi.org/10.1055/s-0036-1589078.

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Pyrrolidines and their derivatives are of great interest in medicinal chemistry and organic synthesis. Fluoropyrrolidines and (fluoroalkyl)pyrrolidines have been utilized in the preparation of medicinal drugs and also as organocatalysts. The synthesis of such compounds is achieved through the fluorination of pyrrolidine derivatives or by multistep synthesis from already containing fluoroalkyl precursors.1 Introduction1.1 General Interest of Fluorine-Containing Pyrrolidines1.2 Fluoroalkylpyrrolidines and the Gauche Effect2 Fluoropyrrolidines2.1 3-Fluoropyrrolidines2.2 3,3- and 3,4-Difluoropyrro

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32

Bell, Russell A., Kieran C. Dickson, and John F. Valliant. "The total synthesis of a technetium chelate - tamoxifen complex." Canadian Journal of Chemistry 77, no. 1 (1999): 146–54. http://dx.doi.org/10.1139/v98-220.

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A potential agent for imaging breast cancer has been synthesized by derivatization of the anti-estrogen tamoxifen. A multistep synthesis was required to conjugate a technetium chelate to tamoxifen in such a fashion that the biodistribution of the complex should mimic that of the parent compound.Key words: tamoxifen, radioimaging, technetium, synthesis.

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33

Kitson, Philip J., Guillaume Marie, Jean-Patrick Francoia, et al. "Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals." Science 359, no. 6373 (2018): 314–19. http://dx.doi.org/10.1126/science.aao3466.

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34

Catellani, M. "The use of palladium complexes in highly selective multistep organic synthesis." Russian Chemical Bulletin 44, no. 3 (1995): 397–405. http://dx.doi.org/10.1007/bf00702374.

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35

Zhu, Jian-Bo, Hao Chen, Lijia Wang, and Yong Tang. "Stereospecific synthesis of highly functionalized benzo[3.1.0]bicycloalkanes via multistep cascade reactions." Org. Chem. Front. 1, no. 8 (2014): 965–68. http://dx.doi.org/10.1039/c4qo00134f.

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36

Kupracz, Lukas, Jan Hartwig, Jens Wegner, Sascha Ceylan, and Andreas Kirschning. "Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions." Beilstein Journal of Organic Chemistry 7 (October 20, 2011): 1441–48. http://dx.doi.org/10.3762/bjoc.7.168.

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The multistep flow synthesis of vinyl azides and their application in the synthesis of vinyltriazoles is reported. The synthesis relies on a stable polymer-bound equivalent of iodine azide that serves to carry out 1,2-functionalization of alkenes in a telescope flow protocol. The intermediate 2-iodo azides are subjected to a DBU-mediated polymer-supported elimination step yielding vinyl azides in good yield. The third step involves the formation of vinyl triazoles by a copper-catalyzed Huisgen-"click" cycloaddition. The required heat is generated by electromagnetic induction based on copper. C

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37

Sahoo, Pathik. "Time Crystal Synthon: The Way to Integrate Cascade Reactions for Advancing Multistep Flow Synthesis." ChemEngineering 7, no. 5 (2023): 88. http://dx.doi.org/10.3390/chemengineering7050088.

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Multistep flow catalytic reactions in organic chemistry integrate multiple sequential organic reactions to enhance cost-efficiency, time management, and labour resources, all while boosting effectiveness and environmental sustainability. Similar to how we select molecular synthons for reactions in retrosynthesis, we can employ time-crystal synthons to integrate catalytic reaction cycles in the development of a reaction pathway. This involves considering individual catalytic reaction steps of cycles as time-consuming events that can be topologically arranged like a clock. This results in a perp

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38

Zhilitskaya, Larisa V., Bagrat A. Shainyan, and Nina O. Yarosh. "Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives." Molecules 26, no. 8 (2021): 2190. http://dx.doi.org/10.3390/molecules26082190.

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The review is devoted to modern trends in the chemistry of 2-amino and 2-mercapto substituted benzothiazoles covering the literature since 2015. The reviewed heterocycles belong to biologically active and industrially demanded compounds. Newly developed synthesis methods can be divided into conventional multistep processes and one-pot, atom economy procedures, realized using green chemistry principles and simple reagents. The easy functionalization of the 2-NH2 and 2-SH groups and the benzene ring of the benzothiazole moiety allows considering them as highly reactive building blocks for organi

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39

Dzhemilev, U. M., and V. A. D'yakonov. "New catalytic organometallic reactions that changed the strategy of organic synthesis." Russian Chemical Reviews 94, no. 6 (2025): RCR5172. https://doi.org/10.59761/rcr5172.

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The review integrates, for the first time, the results of studies carried out in the world over the last 15–20 years on the development and application of fundamental organometallic reactions catalyzed by transition metal complexes that give new carbon–carbon, metal–carbon, and heteroatom–carbon bonds and on the synthesis of small, medium, and large metallacarbocycles containing main group metals (Mg, Al, B). The review addresses data on the use of new organometallic reactions and metallacarbocycles for the preparation of practically important synthetic analogues of natural compounds, Z,Z-dien

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40

Turkyilmaz, Murat, and Fatma Genc. "Multistep Synthesis of Phosphazene Derivative of Chenodeoxycholicacid (CDCA)." Phosphorus, Sulfur, and Silicon and the Related Elements 189, no. 11 (2014): 1723–31. http://dx.doi.org/10.1080/10426507.2014.887080.

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41

Li, Lianhai, and Waepril Kimberly S. Chua. "One-pot multistep synthesis of 3-aminoindolizine derivatives." Tetrahedron Letters 52, no. 12 (2011): 1392–94. http://dx.doi.org/10.1016/j.tetlet.2011.01.087.

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42

Kyprianou, Dimitris, Michael Berglund, Giovanni Emma, et al. "Synthesis of 2,4,6-Trinitrotoluene (TNT) Using Flow Chemistry." Molecules 25, no. 16 (2020): 3586. http://dx.doi.org/10.3390/molecules25163586.

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This paper describes the nitration of 2,4-dinitrotoluene (DNT) and its conversion to 2,4,6-trinitrotoluene (TNT) at a gram scale with the use of a fully automated flow chemistry system. The conversion of DNT to TNT traditionally requires the use of highly hazardous reagents like fuming sulfuric acid (oleum), fuming nitric acid (90–100%), and elevated temperatures. Flow chemistry offers advantages compared to conventional syntheses including a high degree of safety and simpler multistep automation. The configuration and development of this automated process based on a commercially available flo

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43

Stradling, Samuel S., and Clarke L. Gage. "And the winner is . . . A multistep synthesis for the introductory organic course." Journal of Chemical Education 62, no. 12 (1985): 1116. http://dx.doi.org/10.1021/ed062p1116.

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44

Wegner, Jens, Sascha Ceylan, and Andreas Kirschning. "ChemInform Abstract: Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis." ChemInform 43, no. 18 (2012): no. http://dx.doi.org/10.1002/chin.201218270.

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45

Ota, Yusuke, Toshiki Murayama, and Kyoko Nozaki. "One-step catalytic asymmetric synthesis of all-syn deoxypropionate motif from propylene: Total synthesis of (2R,4R,6R,8R)-2,4,6,8-tetramethyldecanoic acid." Proceedings of the National Academy of Sciences 113, no. 11 (2016): 2857–61. http://dx.doi.org/10.1073/pnas.1518898113.

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In nature, many complex structures are assembled from simple molecules by a series of tailored enzyme-catalyzed reactions. One representative example is the deoxypropionate motif, an alternately methylated alkyl chain containing multiple stereogenic centers, which is biosynthesized by a series of enzymatic reactions from simple building blocks. In organic synthesis, however, the majority of the reported routes require the syntheses of complex building blocks. Furthermore, multistep reactions with individual purifications are required at each elongation. Here we show the construction of the deo

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46

Yadav, Amar, and Vinod Pandey. "Multistep organic synthesis leading to the formation of triazinothiazoloquinoxalines involving cost effective rea-gents." International Journal of Scientific World 5, no. 2 (2017): 131. http://dx.doi.org/10.14419/ijsw.v5i2.6154.

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A simple and efficient chemical method has been attempted for the synthesis of biologically and commercially important 2-aryl [-s-] triazino [1], [3], [5] thiazolo [6], [5-b] quinoxalin -4- thiones in moderate to excellent yields through cyclization reaction of o-phenylenediamino using readily available and fewer costly reagents viz. oxalic acid, PCl5thiourea, aromatic aldehydes and ammonium thiocyanate at an ambient temperature.

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47

Shainyan, Bagrat A., Larisa V. Zhilitskaya, and Nina O. Yarosh. "Synthetic Approaches to Biologically Active C-2-Substituted Benzothiazoles." Molecules 27, no. 8 (2022): 2598. http://dx.doi.org/10.3390/molecules27082598.

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Numerous benzothiazole derivatives are used in organic synthesis, in various industrial and consumer products, and in drugs, with a wide spectrum of biological activity. As the properties of the benzothiazole moiety are strongly affected by the nature and position of substitutions, in this review, covering the literature from 2016, we focus on C-2-substituted benzothiazoles, including the methods of their synthesis, structural modification, reaction mechanisms, and possible pharmacological activity. The synthetic approaches to these heterocycles include both traditional multistep reactions and

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48

Hissler, Muriel, Christophe Lescop та Régis Réau. "Functional phosphorus-based π-conjugated systems: Structural diversity without multistep synthesis". Pure and Applied Chemistry 79, № 2 (2007): 201–12. http://dx.doi.org/10.1351/pac200779020201.

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The synthesis and properties of linear π-conjugated systems incorporating phosphole rings are described. Their supramolecular organization in the solid state can be controlled either by chemical modifications or coordination to transition metals of the phosphorus atom. Furthermore, chemical transformations of the phosphole ring allow organizing these P-chromophores in 3D assemblies exhibiting σ-π conjugation or in organometallic ferrocene-like derivatives. Phosphole-pyridine-containing π-conjugated chromophores act as P,N-chelates toward transition-metal ions, giving rise to mono- and di-nucle

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Hemalatha, Kanagarajan, Gunabalan Madhumitha, Amir Kajbafvala, Narayanan Anupama, Rajesh Sompalle, and Selvaraj Mohana Roopan. "Function of Nanocatalyst in Chemistry of Organic Compounds Revolution: An Overview." Journal of Nanomaterials 2013 (2013): 1–23. http://dx.doi.org/10.1155/2013/341015.

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Heterocyclic motif is an important scaffold which has both industrial and pharmaceutical applications. These motifs can be prepared using wide variety of reaction conditions such as the use of expensive catalyst, toxic solvent, harsh reaction condition like the use of base, high temperature, and multistep reaction. Although various methods are involved, the chemistry arena is now shifted towards the greener way of synthesis. Nanocatalyst constitutes an important role in the green synthesis. This is because the activity of the catalyst resides in the exposed portion of the particles. By decreas

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Corey, E. J., Alan K. Long, Theodora W. Greene, and John W. Miller. "Computer-assisted synthetic analysis. Selection of protective groups for multistep organic syntheses." Journal of Organic Chemistry 50, no. 11 (1985): 1920–27. http://dx.doi.org/10.1021/jo00211a027.

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