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1

W, Henggeler Scott. Multisystemic therapy. Boulder, Colo: Center for the Study and Prevention of Violence, Institute of Behavioral Science, University of Colorado at Boulder, 1998.

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2

Multisystemic therapy and neighborhood partnerships: Reducing adolescent violence and substance abuse. New York: Guilford Press, 2009.

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3

M, Borduin Charles, ed. Family therapy and beyond: A multisystemic approach to treating the behavior problems of children and adolescents. Pacific Grove, Calif: Brooks/Cole, 1990.

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4

Black families in therapy: A multisystems approach. New York: Guilford Press, 1989.

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5

Kristi, Sayers L., and Torrey Carol C, eds. Pediatric adapted motor development and exercise: An innovative multisystem approach for professionals and families. Springfield, Ill: C.C. Thomas, 1998.

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6

Schoenwald, Sonja K. The Transport and Diffusion of Multisystemic Therapy. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780195389050.003.0012.

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Chapter 12 describes the many factors that have played a role in the diffusion and implementation of multisystemic therapy (MST), considering policy as well as service provision demands for the intervention, and the development and refinement of procedures to most effectively transport and maintain the adherent administration of this treatment.
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7

Serious Emotional Disturbance in Children and Adolescents: Multisystemic Therapy. The Guilford Press, 2002.

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8

1950-, Henggeler Scott W., ed. Multisystemic therapy for antisocial behavior in children and adolescents. 2nd ed. New York: Guilford Press, 2009.

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9

Henggeler, Scott W., Cynthia Cupit Swenson, Ida S. Taylor, and Oliver W. Addison. Multisystemic Therapy and Neighborhood Partnerships: Reducing Adolescent Violence and Substance Abuse. The Guilford Press, 2004.

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10

1950-, Henggeler Scott W., ed. Multisystemic treatment of antisocial behavior in children and adolescents. New York: Guilford Press, 1998.

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11

Kazdin, Alan E. Psychosocial Treatments for Conduct Disorder in Children and Adolescents. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780199342211.003.0005.

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Significant advances have been made in the treatment of antisocial and aggressive behavior (conduct disorder), a severe source of impairment among children and adolescents. Several psychosocial interventions with strong evidence in their behalf with children and adolescents are highlighted in the chapter. They include parent management training, multisystemic therapy, multidimensional treatment foster care, cognitively based treatments, functional family therapy, brief strategic family therapy, and the Good Behavior Game. The treatments have been very well studied, with multiple replications.
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12

Vladimir, Kvetan, and Dantzker David R, eds. The critically ill cardiac patient: Multisystem dysfunction and management. Philadelphia: Lippincott-Raven, 1996.

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13

(Editor), Vladimir Kvetan, and David R. Dantzker (Editor), eds. The Critically Ill Cardiac Patient: Multisystem Dysfunction and Management. Lippincott Williams & Wilkins, 1996.

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14

Wiffen, Philip, Marc Mitchell, Melanie Snelling, and Nicola Stoner. Therapy-related issues: musculoskeletal diseases. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199603640.003.0025.

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Rheumatoid arthritis 548Gout 556Rheumatoid arthritis (RA) is an autoimmune disease which causes joints lined with synovium to become inflamed, swollen, stiff, and painful, and leads to joint erosion. It is a multisystem disorder which can affect many organs including the eyes, lungs, heart, and blood vessels. The aim of treatment is to decrease pain and inflammation, prevent joint damage, and ultimately induce remission of disease....
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15

Swales, Catherine. Inflammatory connective tissue disease. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.010005.

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♦ Systemic lupus erythematosus (SLE) is the commonest multisystem connective tissue disease♦ All patients with SLE are antinuclear antibody (ANA) positive, but not all ANA-positive patients have SLE♦ Renal lupus carries a high mortality and requires aggressive immunosuppression♦ Dermatomyositis may be associated with malignancy in the elderly♦ The vasculitides are classified according to vessel size and ANCA (antineutrophil cytoplasmic antibody) profile♦ Therapy for vasculitis includes corticosteroids, steroid-sparing agents, and cytotoxics.
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16

Patterson, Marc C. Congenital Disorders of Glycosylation. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0066.

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Congenital disorders of glycosylation (CDG) comprise a family of multisystem diseases in which N- and O-linked glycosylation and glypiation of a variety of proteins and lipids is deficient. The hypoglycosylation of multiple glycoconjugates impairs normal development of the brain (and other organs), and is associated with both episodic and chronic organ dysfunction. Developmental disorders; seizures; strokelike episodes (and stroke); hearing and visual loss; peripheral neuropathy; coagulopathy; and immune, liver, endocrine, cardiac, and cutaneous manifestations may occur in varying combinations
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17

Krause, Andreas, and Volker Fingerle. Lyme borreliosis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0101.

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Lyme borreliosis (LB) is a multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi. The most frequent clinical manifestations include erythema migrans, meningoplyneuritis, and arthritis. Diagnosis of LB is made on clinical grounds and usually supported by a positive serology. Early diagnosis and treatment almost always leads to a rapid healing of the disease. However, in late manifestations gradual remission of symptoms may take several weeks to months. In rare cases, the pathogen can persist for many years or induce a persisting immunopathological response that
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18

Krause, Andreas, and Volker Fingerle. Lyme borreliosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0101_update_001.

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Lyme borreliosis (LB) is a multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi. The most frequent clinical manifestations include erythema migrans, meningoplyneuritis, and arthritis. Diagnosis of LB is made on clinical grounds and usually supported by a positive serology. Early diagnosis and treatment almost always leads to a rapid healing of the disease. However, in late manifestations gradual remission of symptoms may take several weeks to months. In rare cases, the pathogen can persist for many years or induce a persisting immunopathological response that
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19

Fowler, Robert, and Abhijit Duggal. Management of pandemic critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0009.

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Adequate and appropriate provision of critical care services during pandemics may dramatically alter vital outcomes of patients who develop acute respiratory distress syndrome and critical illness. Specific anti-viral therapy, antibiotics directed towards probable secondary infections, supportive ventilation and oxygenation, and adherence to multisystem critical care ‘best practices’ can prevent substantial mortality and morbidity, and lessen the pandemic’s impact on global health. However, severe acute respiratory syndrome and the 2009 H1N1 pandemic also highlighted the limited capacity for i
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20

Noori, Muna, and Catherine Nelson-Piercy. Pathophysiology and management of pre-eclampsia, eclampsia, and HELLP syndrome. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0366.

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Pre-eclampsia is a multisystem disorder of pregnancy, characterized by the gestational onset of hypertension and proteinuria, which presents as part of a spectrum of disease with potentially serious consequences for both mother and foetus. Pre-eclampsia is a syndrome with multiple aetiologies, which has made it difficult to develop adequate screening tests and treatments. Pre-eclampsia is likely to develop only in vulnerable women with a mix of genetic susceptibility, vascular, metabolic, and inflammatory dysfunction. A number of prepregnancy risk factors for pre-eclampsia have been identified
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21

Levtchenko, Elena N., and Mirian C. Janssen. Cystinosis. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0339_update_001.

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Cystinosis is a rare autosomal recessive disease caused by mutations in the lysosomal cystine transporter cystinosin encoded by the CTNS gene (17p.13.2). Cystinosis is characterized by lysosomal cystine accumulation throughout the body with renal Fanconi syndrome being the most common presenting symptom of a multisystem disorder. It must be distinguished from cystinuria in which formation of cystine stones is the core problem. When left untreated, kidney dysfunction gradually progresses towards end-stage renal failure during the first 10 years of life. The advent of renal replacement therapy a
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22

Hall, Andrew, and Shamima Rahman. Mitochondrial diseases and the kidney. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0340.

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Mitochondrial disease can affect any organ in the body including the kidney. As increasing numbers of patients with mitochondrial disease are either surviving beyond childhood or being diagnosed in adulthood, it is important for all nephrologists to have some understanding of the common renal complications that can occur in these individuals. Mitochondrial proteins are encoded by either mitochondrial or nuclear DNA (mtDNA and nDNA, respectively); therefore, disease causing mutations may be inherited maternally (mtDNA) or autosomally (nDNA), or can arise spontaneously. The commonest renal pheno
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