Relevant bibliographies by topics / Munuainen

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  1. Dissertations / Theses

Academic literature on the topic 'Munuainen'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Dissertations / Theses on the topic "Munuainen"

1

Jokela, T. (Tiina). "Analyses of kidney organogenesis through in vitro and in vivo approaches:generation of conditional Wnt4 mouse models and a method for applying inducible Cre-recombination for kidney organ culture." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526201559.

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Abstract In mice, gene targeting has become a useful tool for resolving the functions of proteins and for creating new animal models. Cre/loxP technology has been used broadly for generation of genetically modified mice. The Cre recombinase recognizes a specific DNA sequence, called loxP, and removes any DNA fragment between two loxP-sites. The activity of the Cre recombinase can be controlled spatially and temporally with cell- or tissue-specific promoters and synthetic inducing agents, such as tamoxifen or tetracycline. In this thesis, we employed tamoxifen-induced Cre recombination in vitro
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2

Kaipala, J. (Jukka). "3D-tulostettavan mallin tuottaminen hiiren munuaisen tomografiakuvista." Bachelor's thesis, University of Oulu, 2015. http://urn.fi/URN:NBN:fi:oulu-201509152004.

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Elimistön sisäinen tasapaino on riippuvainen munuaisten toiminnasta, ja krooninen munuaistauti on väestöltään ikääntyvissä länsimaissa yleisimpiä sairastavuutta lisääviä ja kuolemaan johtavia sairauksia. Aikuisen munuaiskudos ei käytännössä uusiudu, ja taudin loppuvaiheessa munuaisensiirto on nykyisellään ainoa hoitokeino, jolla sen kaikki toiminnot voidaan korvata. Hoitokeinojen kehittämistä hidastaa osaltaan se, että munuainen on monimutkainen elin emmekä tunne tarkasti sen kehityksen ja toiminnan mekanismeja. 3D-tulostus on kehittyvä ala, jonka sovelluksilla on suuria tulevaisuuden mahdoll
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3

Naillat, F. (Florence). "Roles of Wnt4/5a in germ cell differentiation and gonad development & ErbB4 in polarity of kidney epithelium." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295751.

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Abstract The embryonic urogenital system generates the metanephric kidneys, the gonads and the adrenal glands, and its development is based on sequential and reciprocal cell and tissue interactions. The mechanisms which regulate urogenital ontogeny are still poorly understood. In this thesis, the roles of Wnt-4 and ErbB4 functions in gonad and kidney development were analysed by using in vivo functional genomic technologies. Wnt-4 is crucial in female development since its absence leads to a partial female to male sex reversal. We found that Wnt-4 mediated the interactions between the somatic
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4

Junttila, S. (Sanna). "Studies of kidney induction in vitro using gene expression profiling and novel tissue manipulation technique." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206608.

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Abstract For decades, the mammalian kidney has served as a model system for studying developmental processes, such as induced epithelialization, branching morphogenesis, and cell differentiations. The possibility to recapitulate and follow the renal organogenesis ex vivo in organ culture set-ups has provided a large amount of molecular and cellular information about sequential events during development. However, certain limitations remain when combining traditional organ culture set-ups with modern molecular technology. This thesis seeks to address these disadvantages. In the experimental part
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5

Murugan, S. (Subramanian). "Control of nephrogenesis by Wnt4 signaling:mechanisms of gene regulation and targeting of specific lineage cells by tissue engineering tools." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789526200323.

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Abstract Wnt4, a member of the Wnt family of secreted factors, is essential for kidney organogenesis since the kidney fails to develop in its absence. Besides the kidney, Wnt4 signaling is involved in the control of development of several other organs such as the gonads, adrenal glands and pituitary gland. In the context of the embryonic kidney, Wnt4 signaling induces mesenchymal to epithelial transition of the progenitor cells in the metanephric mesenchyme, an early step in nephrogenesis. Wnt4 signaling may also be relevant in the development of a childhood kidney tumor, the Wilms’ tumor, tha
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6

Saarela, U. (Ulla). "Novel culture and organoid technologies to study mammalian kidney development." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526218250.

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Abstract Kidney diseases affect an increasing number of people worldwide, and there is a growing demand to develop new treatments and increase the number of transplantable organs. New treatments can be designed when new knowledge is gained by studying the details of kidney development. The ex vivo culture techniques have been used for over a century to study the development of kidneys, but they are not optimal for long-term imaging and following the nephrogenesis process over time. Kidney organoids, which are cellular aggregates resembling the in vivo kidney, together with intact embryonic kid
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7

Ronkainen, J. (Jaana). "Henoch-Schönlein purpura in children: long-term outcome and treatment." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278852.

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Abstract The aim of this work was to evaluate the outcome of childhood Henoch-Schönlein purpura (HSP), the effectiveness of Cyclosporine A (CyA) for treating severe HSP nephritis (HSN), and more particularly the possibility for influencing the course of HSP disease by early prednisone treatment. A total of 47 adults who had had childhood HSP were evaluated after a mean of 24.1 years (16.4–35.6). The outcome was highly dependent on the renal symptoms at onset, since 7 out of 20 adults (20%) who had severe renal symptoms at onset had renal impairment as adults, compared with 2 out of 27 (7%) wit
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8

Salo, J. (Jarmo). "Long-term consequences and prevention of urinary tract infections in childhood." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514298707.

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Abstract Urinary tract infections (UTIs) are among the most common bacterial infections in childhood and have a tendency to recur. The ability of uropathogens to form biofilm may be important in the pathogenesis of UTI. Although childhood UTIs are thought to increase the risk of chronic kidney disease (CKD), evidence showing this association is scarce. Cranberry juice has been shown to prevent UTIs in women, but evidence of its efficacy in children is lacking. The aim of this work was to evaluate the significance of biofilm formation for the clinical presentation of UTI, the long-term conseque
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9

Pietilä, I. (Ilkka). "The role of Dkk1 and Wnt5a in mammalian kidney development and disease." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207216.

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Abstract This thesis focuses on mammalian kidney development and in particular on the question of how two Wnt signalling pathway genes, an antagonistic Dkk1 and an agonistic ligand Wnt5a, regulate the process. Wnts are secreted ligands that are involved in many developmental processes, including gonadal differentiation and kidney development, but also in various diseases and malformations. Wnts form a large signalling family containing 19 different glycoprotein ligands in mammals. Wnt signalling occurs via two different intracellular pathways. A canonical pathway proceeds via beta-catenin, and
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10

Vasunta, R. L. (Riitta-Liisa). "Ambulatory blood pressure:association with metabolic risk indicators, renal function and carotid artery atherosclerosis." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514299605.

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Abstract Blood pressure is usually measured on a clinic visit as a momentary value. It can also be defined as a continuum based on several repeated measurements. Ambulatory blood pressure measurement (ABPM) is a method of repeated BP measurements targeted to evaluate the circadian blood pressure (BP). Nondipping, i.e., the lack of reduction of BP during the night, has been shown to associate with cardiovascular endpoints. The aim of this study was to investigate the association between 24-hour ABPM and cardio-metabolic confounders in a cross-sectional, population-based study design. Particular
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