Journal articles: 'Mur'

1

Fathy, Safaa. "De mur en mur." Rue Descartes 92, no. 2 (2017): 6. http://dx.doi.org/10.3917/rdes.092.0006.

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2

Mahjoub, Lilia. "Du mur à l’(a)mur." La Cause du Désir N° 110, no. 1 (March 30, 2022): 26–46. http://dx.doi.org/10.3917/lcdd.110.0026.

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3

GHw§$S>o, Amem ¶ed§V, and G§{JVm Gmido. "qnnar-qMMdS> n[agamVrb ~mbJwÝhoJmar : EH$ gm‘m{OH$ d Am{W©H$ g‘ñ¶m." SCHOLARLY RESEARCH JOURNAL FOR INTERDISCIPLINARY STUDIES 10, no. 73 (September 1, 2022): 17555–64. http://dx.doi.org/10.21922/srjis.v10i73.11655.

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4

Eniyan, Kandasamy, Jyoti Rani, Srinivasan Ramachandran, Rahul Bhat, Inshad Ali Khan, and Urmi Bajpai. "Screening of Antitubercular Compound Library Identifies Inhibitors of Mur Enzymes in Mycobacterium tuberculosis." SLAS DISCOVERY: Advancing the Science of Drug Discovery 25, no. 1 (October 9, 2019): 70–78. http://dx.doi.org/10.1177/2472555219881148.

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The rapid rise in the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb) mandates the discovery of novel tuberculosis (TB) drugs. Mur enzymes, which are identified as essential proteins in Mtb and catalyze the cytoplasmic steps in the peptidoglycan biosynthetic pathway, are considered potential drug targets. However, none of the clinical drugs have yet been developed against these enzymes. Hence, the aim of this study was to identify novel inhibitors of Mur enzymes in Mycobacterium tuberculosis. We screened an antitubercular compound library of 684 compounds, using MurB and MurE enzymes of the Mtb Mur pathway as drug targets. For experimental validation, the top hits obtained on in silico screening were screened in vitro, using Mtb Mur enzyme-specific assays. In all, seven compounds were found to show greater than 50% inhibition, with the highest inhibition observed at 77%, and the IC50 for these compounds was found to be in the range of 28–50 μM. Compound 5175112 showed the lowest IC50 (28.69 ± 1.17 μM), and on the basis of (1) the binding affinity, (2) the stability of interaction noted on molecular dynamics simulation, and (3) an in vitro assay, MurE appeared to be its target enzyme. We believe that the overall strategy followed in this study and the results obtained are a good starting point for developing Mur enzyme-specific Mtb inhibitors.

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5

Thody, Philip, Jean-Paul Sartre, and Walter Redfern. "Le Mur." Modern Language Review 94, no. 2 (April 1999): 549. http://dx.doi.org/10.2307/3737182.

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6

Houssais, Yvon. "Le Mur." Roman 20-50 Hors série n° 10, no. 1 (March 10, 2022): 121–33. http://dx.doi.org/10.3917/r2050.hs10.0121.

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7

Barrat, Claudie. "Le mur." Études rurales, no. 173-174 (November 15, 2005): 109–26. http://dx.doi.org/10.4000/etudesrurales.8134.

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8

Conte, Édouard. "L’autre mur." Études rurales, no. 173-174 (November 15, 2005): 127–52. http://dx.doi.org/10.4000/etudesrurales.8135.

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9

Riungu, T. C., and P. B. E. McVetty. "Development and evaluation of Diplotaxis muralis (mur) cytoplasmic male sterility system in summer rape." Canadian Journal of Plant Science 83, no. 2 (April 1, 2003): 261–69. http://dx.doi.org/10.4141/p02-093.

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The Diplotaxis muralis male sterility inducing cytoplasm (mur cytoplasm) and its maintainer genes were transferred from the winter rapeseed male sterile line Mangun mur CMS A-line and the mur CMS maintainer line Mangun mur CMS B-line, respectively, into summer rape lines genetically related to the open-pollinated population cultivars Regent and Karat using standard cross, backcross and test cross breeding procedures. Three genetically identical summer rape mur CMS A-line and B-line pairs, Karat I A-line and B-line, Karat II A-line and B-line and Regent A-line and B line were developed. Flower morphology studies revealed that the mur CMS A-lines had anthers displaying a complete absence of pollen and floral morphology modifications similar to that seen for other CMS systems in summer rape. Seedling emergence, days to first flower, days to maturity, and height of the vernalized mur CMS Mangun A-line and B-line pair and the summer rape mur CMS A-line and B-line pairs were similar among treatments and equal for A-line and B-line pair comparisons within cultivars for plants grown in the greenhouse. There was no evidence of biological benefits or costs associated with the mur cytoplasm. The male sterility for the vernalized Mangun mur CMS A-line and the summer rape mur CMS A-lines was stable at temperatures up to 30/24EC. Key words: Brassica napus L., male sterility, temperature stability

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10

Díaz-Mireles, Edit, Margaret Wexler, Jonathan D. Todd, Dominico Bellini, Andrew W. B. Johnston, and R. Gary Sawers. "The manganese-responsive repressor Mur of Rhizobium leguminosarum is a member of the Fur-superfamily that recognizes an unusual operator sequence." Microbiology 151, no. 12 (December 1, 2005): 4071–78. http://dx.doi.org/10.1099/mic.0.28342-0.

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The manganese uptake regulator Mur of Rhizobium leguminosarum is a close homologue of the global iron regulatory protein Fur. Mur represses the sitABCD operon, which encodes a Mn2+ transport system, specifically in response to Mn2+ but not Fe2+. In previous work the authors mapped the 5′ ends of two sit operon transcripts, termed TS1 and TS2, which were co-ordinately regulated by Mn2+-Mur, but this paper now shows that only TS1 is a primary transcript. DNase I protection analyses showed that purified Mur bound, with similar affinity, to two sites in the regulatory region of sitABCD, but only when Mn2+ was present in the reaction buffer. These Mn2+-Mur-binding sites, termed MRS1 and MRS2 (Mur-responsive sequence), were closely related in sequence to each other and were separated by 16 bp, spanning the transcription initiation site TS1. The extent of the protected DNA was 34 and 31 bp for MRS1 and MRS2, respectively, which is in accord with other members of the Fur family. The DNA sequences recognized by Mn2+-Mur are wholly different from conventional Fur boxes, but some similarities to a recognition sequence for the Fur regulator from Bradyrhizobium japonicum were noted. Transcription analysis of the R. leguminosarum mur gene showed its expression to be independent of Mn2+-Mur. Thus, Mur is a sequence-specific DNA-binding protein that responds in vitro to manganese, and thus can occlude RNA polymerase access to the sitABCD promoter. Moreover, Mur recognizes a DNA sequence atypical for the Fur superfamily and, like Fur from B. japonicum, defines a new subclass of Fur-like transcriptional regulators.

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11

McCormack, Ursula M., Mikkel Klausen, Lisa A. Laprade, Sonja Christian, Carsten Østergaard Frederiksen, Maria C. Walsh, Tsungcheng Tsai, Charles V. Maxwell, and Casey L. Bradley. "174 The effect of a microbial Muramidase on peptidoglycan content in the gut of swine using in-vitro and in-vivo measures." Journal of Animal Science 98, Supplement_3 (November 2, 2020): 79–80. http://dx.doi.org/10.1093/jas/skaa054.142.

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Abstract Bacterial debris in the gastrointestinal tract (GIT) are continuously being produced by the microbiota present upon bacterial division and death. One of the most abundant components in bacterial debris are peptidoglycans (PGN), a structural cell wall component in gram- positive and negative bacteria. The objective of this work was to investigate if addition of a novel microbial muramidase (Muramidase 007; MUR) that hydrolyzes PGN, would reduce PGN adhesion to porcine intestinal cells in-vitro and hydrolyze PGN in the GIT of swine. Adhesion efficacy of intact and MUR hydrolyzed fluorescein-isothiocyanate (FITC)-labelled PGN were compared using fluorescence-microscopy (3 wells/condition). Catalytic performance of MUR on intact FITC-labelled PGN adhered to intestinal cells were also tested. In-vivo MUR-supplementation at 50,000 LSU/kg diet to gestating and lactating sows and/or their subsequent offspring for 42-d post-weaning was investigated. Mass-spectroscopy was used to quantify soluble and total muramic acid, which is only found in PGN, in the ileal and cecal digesta (8 piglets/treatment) to calculate percentage soluble-PGN. Cell-culture data were analyzed using GraphPad-Prism 8.0 and in-vivo data using mixed-models in JMP 14.0. MUR hydrolyzed PGN adhered 10x less to the IPEC-J2 cell line culture compared to intact-PGN (P< 0.05). In addition, data show that MUR hydrolyzed PGN attached to cell surfaces by 2x, as attached PGN were also reduced by 50% following MUR incubation (P< 0.05). Offering sows MUR-diets had no carryover effect on the percentage soluble PGN in their piglets’ digesta, and there were no interactions observed for sow x piglet x tract neither (P >0.05). Percentage soluble-PGN increased in piglets fed MUR compared to control-piglets (47.18 vs. 29.84% SEM:1.624; P< 0.001) and was higher in cecal digesta compared to ileal digesta (49.91 vs. 27.11%; SEM:1.634; P< 0.001), irrespective of MUR-supplementation. These results suggest that MUR may reduce PGN adhesion to intestinal cells and may hydrolyze PGN found in the GIT.

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12

Cibik, Recep, Patrick Tailliez, Philippe Langella, and Marie-Pierre Chapot-Chartier. "Identification of Mur, an Atypical Peptidoglycan Hydrolase Derived from Leuconostoc citreum." Applied and Environmental Microbiology 67, no. 2 (February 1, 2001): 858–64. http://dx.doi.org/10.1128/aem.67.2.858-864.2001.

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ABSTRACT A gene encoding a protein homologous to known bacterialN-acetyl-muramidases has been cloned fromLeuconostoc citreum by a PCR-based approach. The encoded protein, Mur, consists of 209 amino acid residues with a calculated molecular mass of 23,821 Da including a 31-amino-acid putative signal peptide. In contrast to most of the other known peptidoglycan hydrolases, L. citreum Mur protein does not contain amino acid repeats involved in cell wall binding. The purifiedL. citreum Mur protein was shown to exhibit peptidoglycan-hydrolyzing activity by renaturing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. An active chimeric protein was constructed by fusion of L. citreum Mur to the C-terminal repeat-containing domain (cA) of AcmA, the major autolysin of Lactococcus lactis. Expression of the Mur-cA fusion protein was able to complement an acmA mutation inL. lactis; normal cell separation after cell division was restored by Mur-cA expression.

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13

Olcay, Tijen. "L'Invisible Mur D'Istanbul." Symposium: A Quarterly Journal in Modern Literatures 59, no. 1 (April 2005): 19–29. http://dx.doi.org/10.3200/symp.59.1.19-29.

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14

Diamanti, Ilvo. "Un nouveau mur." Critique internationale 18, no. 1 (2003): 159. http://dx.doi.org/10.3917/crii.018.0159.

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15

Roux, Marie-Lise. "Un mur infranchissable." Revue française de psychosomatique 36, no. 2 (2009): 27. http://dx.doi.org/10.3917/rfps.036.0027.

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16

Sokolowsky, Laura. "Mur, amur, amour." La Cause du Désir N° 110, no. 1 (March 30, 2022): 7–8. http://dx.doi.org/10.3917/lcdd.110.0007.

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17

Dambrine, Sylvain. "passages du mur." Vacarme 29, no. 4 (2004): 146. http://dx.doi.org/10.3917/vaca.029.0146.

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18

Léon, Vladimir. "Derrière le mur." Vertigo 31, no. 2 (2007): 81. http://dx.doi.org/10.3917/ver.031.0081.

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19

Grésillon, Boris. "Un mur d’incompréhension." Esprit Mai, no. 5 (May 3, 2021): 125–35. http://dx.doi.org/10.3917/espri.2105.0125.

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20

Mincke, Christophe. "Éviter le mur." La Revue Nouvelle N° 7, no. 7 (October 6, 2022): 2–4. http://dx.doi.org/10.3917/rn.225.0002.

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21

Jungers, Jean-Jacques. "L’homme sans mur :." Les Pages du laa 9, no. 29 (August 24, 2023): 1–58. http://dx.doi.org/10.14428/lpl.v9i29.75813.

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Empruntant à Jacques Lacan le modèle du nœud borroméen, Jean-Jacques Jungers définit les concepts de « scène », d’« obscène » et de « monde » pour mieux déplier les opérations au travers desquelles l’architecture, simultanément, met en forme (scène) nos lieux de vie, tout en produisant un reste (obscène), qu’elle dissimule pour mieux garantir notre quiétude (monde). Illustrant ce mécanisme, à ses yeux caractéristique de la manière dont l’animal humain « civilise » son milieu, Jean-Jacques Jungers analyse une reconstitution du Temple d’Apollon de Didymes. L’architecture conforte et ré-conforte, mais c’est au prix à la fois d’un rejet et d’une dissimulation. Alors se pose une question inquiétante : que nous cache notre architecture ?

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22

Amer, Shimaa A., Mahmoud Farahat, Ahmed Gouda, Ahmed A. A. Abdel-Wareth, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Gehad Elsaid Elshopakey, et al. "New Insights into the Effects of Microbial Muramidase Addition in the Diets of Broiler Chickens." Animals 13, no. 8 (April 15, 2023): 1356. http://dx.doi.org/10.3390/ani13081356.

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The study aimed to explore how broiler chickens’ blood biochemistry, breast muscles’ fatty acid profile, growth, intestinal morphology, and immune status would be influenced by adding microbial muramidase (MUR) to the diet. Four hundred 3-day-old male broiler chickens were allocated to a completely randomized design consisting of four nutritional treatments (n = 100 per treatment, 10 chicks/replicate), each containing MUR at levels of 0 (control group), 200, 400, and 600 mg Kg−1 diet, with enzyme activity 0, 12,000, 24,000, and 36,000 LSU(F)/kg diet, respectively. The 35-day experiment was completed. The findings showed that adding MUR to broiler meals in amounts of 200, 400, or 600 mg/kg had no impact on growth performance (p > 0.05) during the periods of 4–10, 11–23, and 24–35 days of age. MUR supplementation quadratically impacted the feed conversion ratio of broiler chicks at 11 and 23 days of age (p = 0.02). MUR addition to the diet significantly and level-dependently enhanced the percentage of n−3 and n−6 polyunsaturated fatty acids (PUFA) in breast muscles (p ≤ 0.01), with no alterations to the sensory characteristics of the breast muscles. Dietary MUR increased most of the morphometric dimensions of the small intestine, with the best results recorded at the 200 and 400 mg Kg−1 levels. MUR supplementation at 200, 400, and 600 mg kg−1 linearly lowered the total cholesterol, triglycerides, and low-density lipoprotein cholesterol level (p < 0.01). Still, it significantly increased the high-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol contents compared with the unsupplemented group. Compared to controls, there was a substantial rise in the blood concentration of total protein, albumin, globulin, IL10, complement 3, and lysozyme activity as MUR levels increased (p < 0.01). Moreover, MUR addition significantly increased the immunoexpression of lymphocyte subpopulation biomarkers. We could conclude that MUR can be added to broiler chicken diets up to 600 mg kg −1 to improve broiler chickens’ fatty acid profile in breast muscles, immunity, and blood biochemistry. MUR addition had no positive influence on the bird’s growth.

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23

Preetha, SP. "Insights from the molecular docking analysis of compounds from Vitex negundo with targets from Klebsiella pneumonia causing urinary tract infection." Bioinformation 18, no. 11 (November 30, 2022): 1062–68. http://dx.doi.org/10.6026/973206300181062.

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Antimicrobial resistance among bacterial strains has emerged out to be a serious threat and contributes to the loss of effectiveness of the common antibiotics. New Delhi metallo-β-lactamase-1 (blaNDM-1) is an enzyme present in several pathogenic bacteria with a high incidence in Klebsiella pneumoniae and plays a crucial role in the development of antibacterial resistance. Mur enzymes are also important alternative drug targets in addition to blaNDM-1 which are crucial for the survival of the bacteria. Vitex negundo is an aromatic medicinal tree with proven antibacterial properties. Fifteen compounds from V. negundo were evaluated for their inhibitory effects on the target proteins blaNDM-1, Mur C, Mur E and Mur F of K. pneumoniae through molecular docking using the Glide (xp) module of Schrodinger. ADME toxicity was also predicted for all the fifteen compounds in the QikProp module. The docking results revealed that the compounds agnuside, negundoside and isoorientin showed promising inhibitory effects on all four targets blaNDM-1, Mur C, Mur E and Mur F of K. pneumoniae with docking scores greater than -7 kcal/mol and reasonable hydrogen bond interactions. The findings of this study provide a lead for developing novel drugs against potent multidrug-resistant K. pneumoniae.

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24

Zulfa, Zulfa Adi Muslim, and Nurhadi. "Pengaruh Jumlah Pisau Pengaduk Dan Putaran Spin Disk Terhadap Mikrostruktur Permukaan Mur dan Baut Pada Mesin Cuci Mur Dan Baut Otomatis." Teknobiz : Jurnal Ilmiah Program Studi Magister Teknik Mesin 13, no. 1 (March 29, 2023): 17–24. http://dx.doi.org/10.35814/teknobiz.v13i1.4844.

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Service kendaraan pada bengkel otomotif seringkali terjadi kendala efisiensi waktu pelayanan, sebab terkendala dalam melakukan pekerjaan pembersihan pada mur dan baut. Melihat adanya masalah pada bengkel peneliti mencoba memberikan solusi berupa alat pencuci mur dan baut yang kemudian diteliti hasil cuciannya untuk mengetahui seberapa bersih hasil cucian dari alat ini. Penelitian menggunakan metode eksperimen, menggunakan 2 variabel bebas yaitu 1, 2 dan 3 pisau pengaduk dan putaran spin disk 100, 200 dan 300 Rpm, 1 variabel terikat hasil mikrostruktur mur dan baut. Hasil menunjukkan variabel jumlah pisau pengaduk berpengaruh signifikan terhadap mikrostruktur mur dan baut, dan variabel putaran spin disk tidak berpengaruh signifikan terhadap mikrostruktur mur dan baut, berdsarkan analisis grafik pada variasi putaran spin disk 100,200 dan 300 Rpm dan menggunakan 1 pisau pengaduk didapatkan area karat yang tinggi yaitu 97,96 dan 92 % area karat. Hasil dibuktikan dengan analisis two-way Anova, berdasarkan analisis jumlah pengaduk mendapatkan nilai P-Value 0,007 yang berarti 0,007< 0,05 maka terdapat pengaruh signifikan pada variabel bebas jumlah pisau pengaduk terhadap mikrostruktur mur dan baut, nilai P-value dari putaran spin disk sebesar 0,095 yang berarti 0,095 > 0,05 maka tidak terdapat pengaruh signifikan pada variabel bebas putaran spin disk terhadap mikrostruktur permukaan mur dan baut.

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Mondal, Sandhimita, Nirman Chandra Sukul, and Soma Sukul (nee Chunari). "Natrum mur 200c promotes seed germination and increases total protein, chlorophyll, rubisco and sugar in early seedlings of cowpea under salt stress." International Journal of High Dilution Research - ISSN 1982-6206 11, no. 40 (December 21, 2021): 128. http://dx.doi.org/10.51910/ijhdr.v11i40.570.

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Background: High level of salinity deteriorates seed germination, growth and yield of crops in cultivated lands all over the world. There is no effective remedy to mitigate this global problem. Homeopathy offers a remedy like Natrum mur which at ultra high dilution ameliorates diseases of patients having strong desire for salt consumption. The purpose of the present study is to see whether potentized Natrum mur could alleviate salt stress in germinating seeds of cowpea Vigna unguiculata (L) Walp. Methods: Water-soaked seeds were kept over moist filter paper in covered petridishes which were divided into 5 groups: (1) unstressed and untreated control in sterile distilled water, (2) in 100mM sodium chloride solution, (3) seeds pretreated with Natrum mur 200c and then kept in sterile distilled water, (4) seeds pretreated with Natrum mur 200c and then transferred to 100mM NaCl solution and (5) seeds pretreated with 90% ethanol. Both Natrum mur 200 c and its diluent medium 90% ethanol were diluted with distilled water 1:100 before use for treatment. Results: Natrum mur 200c increased the rate of seed germination, seed water content and growth of seedlings. The drug also enhanced chlorophyll, soluble and insoluble sugar, rubisco and total protein content as compared to the untreated salt stressed group. Treatment with Natrum mur 200c increased salt tolerance in the seedlings as compared to the untreated salt stressed group. All the data were analyzed by ANOVA and the significance level was not less than 1%. Conclusion: Natrum mur 200c reversed the effects of salt stress in germinated seeds thereby providing evidence for HahnemannÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s similia principle in plants. Potentized Natrum mur could be safely used with profit on plants grown on brackish soil.

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26

K Svensson, O., G. Németh, and J. Ekholm. "Relative Mechanical Load on Back and Hip Muscles in Standing Position When Handling Materials Manually. A Study of Packing Work." Journal of Rehabilitation Medicine 19, no. 4 (June 4, 2020): 159–68. http://dx.doi.org/10.2340/165019778719159168.

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Muscular load on the back and hip muscles was quantified and compared using a muscular strength utilization ratio (MUR). The MUR was obtained by dividing the total moment about the bilateral joint axis by the counteracting maximum muscular strength at the same joint angle. 72 different postures during simulated packing work were studied, with different combinations of box size, angle, edge height and weight. The MUR was calculated for a large, an average sized and a small man depending on whether they were all either strong, of average strength, or weak, thus giving nine MUR values for each posture. For a weak man, the MUR exceeded 100% in many postures. The largest box at a zero- or 30-degree angle to the horizontal with its upper edge 20 cm below elbow height gave the highest MUR, while the smallest box angled at 90 degrees with the upper edge 10 cm above elbow height gave the lowest. The presented concept of relating joint load to strength is proposed for use in preventive ergonomic counselling and in vocational rehabilitation.

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27

Riungu, T. C., and P. B. E. McVetty. "Inheritance of maintenance and restoration of the Diplotaxis muralis (mur) cytoplasmic male sterility system in summer rape." Canadian Journal of Plant Science 83, no. 3 (July 1, 2003): 515–18. http://dx.doi.org/10.4141/p02-077.

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The inheritance of Diplotaxis muralis (L) DC. mur cytoplasmic male sterile (CMS) system maintenance and restoration in summer rape (Brassica napus L.) was studied by crossing eight summer rape cultivars of diverse origin to a winter habit mur CMS A-line. The F1 progenies from all eight crosses were male fertile and were selfed to produce the F2 generation. The F2 generation was grown in the field and data on segregation for male fertility and sterility were recorded and analyzed. The F2 segregation data showed that mur CMS restoration in summer rape is controlled by dominant alleles at one to three restorer genes. The number of genes for the restoration of male fertility in mur CMS varied both among and, occasionally, within cultivars. Maintainer lines for mur CMS must carry recessive alleles in homozygous condition at all three restorer genes. The ready availability of summer rape restorers suggests that the mur CMS system has good potential for hybrid cultivar development and hybrid seed production in summer rape; however, maintainers in summer rape must first be discovered or developed. Key words: Cytoplasmic male sterility, canola, Brassica napus, male sterility

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28

Riungu, Teresio C., and Peter B. E. McVetty. "Comparison of the effect of mur and nap cytoplasms on the performance of intercultivar summer rape hybrids." Canadian Journal of Plant Science 84, no. 3 (July 1, 2004): 731–38. http://dx.doi.org/10.4141/p02-163.

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The performance of six isogenic pairs of male fertility restored, hand-crossed, summer rape (Brassica napus L.) hybrids, in the mur and nap cytoplasms, were investigated in four Manitoba environments. Hybrids in both cytoplasms exhibited high-parent heterosis for seed yield, total dry matter (TDM) and, to a lesser degree, harvest index (HI). Negative high parent heterosis for days to flowering, days to maturity, oil concentration and protein concentration was observed. Combined over hybrids within cytoplasms, the mur and nap cytoplasmic hybrid groups differed in oil concentration in all environments, and in protein concentration in one of four environments. Similarly, the mur hybrid group was lower-yielding and had lower TDM, HI and oil concentration, but higher protein concentration than the nap hybrid group. Even though there are some biological costs associated with the mur cytoplasm, especially for oil concentration, it appears that the mur cytoplasmic male sterility (CMS) system has good potential for use in summer rape hybrid cultivar breeding and commercial hybrid seed production, since hybrids in the mur cytoplasm display heterosis for many traits in absolute terms. Key words: Biological cost, Brassica napus L., cytoplasmic male sterility, heterosis, hybrid

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29

Kozar, Michael P., Jon D. Laman, and Alvin Fox. "Muramic Acid Is Not Generally Present in the Human Spleen as Determined by Gas Chromatography-Tandem Mass Spectrometry." Infection and Immunity 70, no. 2 (February 2002): 741–48. http://dx.doi.org/10.1128/iai.70.2.741-748.2002.

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ABSTRACT It has been hypothesized that bacterial debris may accumulate in tissues of the reticuloendothelial system (RES) serving as an inflammatory stimulus for human disease. In support of this hypothesis, muramic acid (Mur), a component of bacterial peptidoglycan (PG), has previously been reported to be present in culture-negative human spleen. High-performance liquid chromatography (HPLC) was employed in these analyses, and a peak was detected at the retention time of Mur. However, HPLC is best used as a screening technique, and it is vital that these tentative observations be reexamined by the state-of-the-art approach (gas chromatography-tandem mass spectrometry [GC-MS2]). Indeed, in the present work using GC-MS2, Mur was not detected in six out of seven human spleens previously examined by HPLC. However, Mur was categorically detected at minute concentrations, 50 ppb, in one spleen. In conclusion, since Mur is not generally found in culture-negative human spleen, in future studies, these tissues can serve as negative controls. The study of Mur levels in inflammation (e.g., reactive arthritis) could prove important in testing the hypothesis that bacterial debris persisting in tissues could serve as a depot inciting diseases of unknown etiology.

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Manfrin, Andrea, and Janet Krska. "Pharmacists’ and patients’ views and feedback on Italian Medicines Use Review (I-MUR)." European Journal for Person Centered Healthcare 6, no. 2 (June 1, 2018): 286. http://dx.doi.org/10.5750/ejpch.v6i2.1463.

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Rationale, aims and objectives: Although medicine review services are offered by community pharmacists in many countries, they are non-existent in Italy. A novel intervention, I-MUR, was developed for patients with asthma aiming to improve medicines use. The aim of this study was to obtain pharmacists’ and patients’ views on the acceptability of the I-MUR service provided by community pharmacists to asthma patients in 4 Italian regions. Methods: Pharmacists’ expectations, experiences and attitudes to delivering the I-MUR were obtained through questionnaires distributed before and after delivering the I-MUR, plus focus groups. Patients’ views were obtained via questionnaires, distributed by the pharmacists and returned anonymously.Results: Seventy-four pharmacists provided the I-MUR service to 895 asthma patients; 49 pharmacists completed both questionnaires, 53 participated in focus groups and 246 patients returned questionnaires. Barriers anticipated most frequently by pharmacists before the I-MUR were lack of time (53%) and lack of co-ordination with other health professionals (61%), while lack of financial compensation was identified by 37%. Lack of co-ordination proved the most common actual barrier (88%), with lack of financial compensation being cited less frequently after providing the intervention (8%). Ninety-six percent of pharmacists anticipated providing both education on inhaler technique and medication counselling, but in practice slightly fewer had provided these (90% and 86% respectively). Focus groups highlighted a lack of relevant undergraduate education to support medication review and structural barriers within some pharmacies, but described positive patient feedback and a desire to extend the I-MUR. Patient respondents were positive; 62% indicated the reason for having an I-MUR as making sure that they were using medication correctly, 75% considered they benefited from it and 86% would recommend it to others.Conclusions: The I-MUR service was perceived positively by both pharmacists and patients, supporting the extension of medicine review services to community pharmacists in Italy in an enhancement of the person-centeredness of care.

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Riungu, Teresio C., and Peter B. E. McVetty. "Diplotaxis muralis (mur) cytoplasmic male sterility system maintainer occurrence and frequency in summer rape." Canadian Journal of Plant Science 80, no. 3 (July 1, 2000): 587–89. http://dx.doi.org/10.4141/p99-145.

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No male sterile plants were found in the F1 progeny from crosses between a Diplotaxis muralis cytoplasmic male sterile (mur CMS) semi-winter habit rape (Brassica napus L.) A-line and 101 genetically diverse summer rape cultivars or strains. The frequency of occurrence of mur CMS system maintainer genotypes in summer rape is very low, possibly zero. Key words: Mur CMS system; Brassica napus L.

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Vasylenko, V. "ARTISTIC UKRAINIAN MOVEMENT AS A PHENOMENON AND FACT OF THE POST-WAR LITERARY PROCESS." Вісник Житомирського державного університету імені Івана Франка. Філологічні науки, no. 3(98) (December 23, 2022): 18–34. http://dx.doi.org/10.35433/philology.3(98).2022.18-34.

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The paper deals with the most important events and processes in the history of the Artistic Ukrainian Movement (MUR) as a literary and artistic organization of Ukrainian writers and a phenomenon of Ukrainian literary life in the post-war period. The article focuses upon the content of the artistic, aesthetic and ideological foundations on which the MUR was formed, as well as some organizational aspects of its literary activity. The study deals with the role of the MUR in the literary and artistic life of the post-war Ukrainian emigration is analyzed, in particular, the content of three writer’s congresses (1945, 1947, and 1948) and three conferences (1946) devoted to the problems of the development of literary criticism and drama, and their historical and cultural, and intellectual worldview contexts. The rticle touches upon the issues of continuity of the ideological, creative and organizational principles of the MUR, in particular, the orientation of its creators onto the tradition of VAPLITE; there is a continuation of the MUR’s traditions in the association of Ukrainian writers in exile "Slovo" ("The Word"), which arose later, is noted. The topic of the discussion between the MUR and the idealistic group that separated from MUR, which was called "Svitannia" ("The Dawn"), and soon turned into opposition to it, is revealed. The article argues that the MUR played an important role in restoring Ukrainian literary life in emigration, and the congresses and conferences it held demonstrated the productivity of artistic and literary-critical developments of Ukrainian writers and literary critics, the fruitfulness and diversity of their ideological and aesthetic searches. The analysis involved memoirs, letters, articles of Ukrainian writers and literary critics involved in the creation and activities of the MUR.

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Hidayatullah, Riyan. "Komunikasi Musikal dalam Konser “Musik Untuk Republik”." Tonika: Jurnal Penelitian dan Pengkajian Seni 4, no. 2 (November 28, 2021): 145–60. http://dx.doi.org/10.37368/tonika.v4i2.254.

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Konser merupakan istilah untuk pertunjukan musik yang disajikan di depan penggemarnya. Selain berfungsi sebagai sarana interaksi antara musisi dan penikmat musik, konser juga dapat menjadi alat politik tertentu. Penelitian ini menggunakan pendekatan teori komunikasi musikal dan politik. Tujuannya untuk mengidentifikasi makna dibalik pesan-pesan politik dan musikal pada penyelenggaraan konser Musik untuk Republik (MUR) yang diadakan 18-20 oktober 2019 yang lalu. Fitur-fitur dalam aplikasi NVIVO12 digunakan untuk mengidentifikasi kata kunci yang banyak dibicarakan, sentimen, hubungan dan makna dibalik respon masyarakat terhadap MUR, dan mempertajam temuan dan konsep. Sebanyak 14 situs berjenis halaman web dan kanal YouTube diakses untuk mengumpulkan informasi tentang konser MUR dan tanggapan-tanggapannya. Hasil analisis menunjukkan bahwa terdapat komunikasi politik yang ingin disampaikan oleh musisi kepada pemerintah. Pertemuan antara musisi dengan Presiden Jokowi dianalisa sebagai upaya membangun akses ke pemerintahan, membangun kedekatan (proximity), dan kaderisasi musisi di parlemen. Pesan-pesan persatuan juga disampaikan oleh Presiden kepada masyarakat melalui konser MUR. Konser musik MUR juga digunakan sebagai medium untuk memberikan informasi publik.

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Asih, Puji, Iva Mindhayani, and Hendra Saputra. "Pengendalian Persediaan Mur Baut Untuk Perawatan Gerbong Kereta Api Menggunakan Metode Eqonomic Order Quantity (EOQ) dan Just In Time (JIT)." Jurnal Rekayasa Industri (JRI) 5, no. 1 (April 21, 2023): 43–52. http://dx.doi.org/10.37631/jri.v5i1.904.

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Satria Saka Pratama divisi warehouse merupakan gudang persediaan barang dan spare part diantaranya adalah mur baut yang digunakan untuk kelancaran dan perawatan gerbong kereta api. Pada penelitian ini bertujuan untuk mengetahui ongkos total pengendalian persediaan mur baut sesuai kebijakan perusahaan, menggunakan metode EOQ dan JIT. Mengetahui metode yang paling efisien untuk ongkos total persediaan mur baut per tahunnya. Untuk mengetahui efisiensi ongkos total persediaan menggunakan metode EOQ maupun JIT, maka harus mengeahui dahulu ongkos total persediaan kebijakan perusahaan. Setelah mengetahui ongkos total persediaan kebijakan perusahaan, selanjutnya harus mengetahui ongkos total persediaan menggunakan metode EOQ maupun JIT. Selanjutnya membandingkan ongkos total tersebut dan tentukan ongkos total yang paling efisien. Hasil penelitian menunjukan ongkos total persediaan mur baut kebijakan perusahaan Rp 80.567.099,563, ongkos total persediaan menggunakan metode EOQ Rp 63.016.649,55 dan ongkos total persediaan menggunakan metode JIT aspek tingkat persediaan rata- rata Rp 55.091.897,34. Ongkos total persediaan mur baut yang paling efisien adalah metode JIT aspek tingkat persediaan rata-rata nilainya Rp 55.091.897,34.

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Aji, Daisman, Dodi Iwan Sumarno, and Triyono. "ANALISIS AKAR MASALAH KEGAGALAN CACAT RETAK (CRACK) PADA PROSES PEMBENTUKAN TEMPA DINGIN (COLD FORMING) MUR M14." Jurnal Rekayasa Teknologi Nusa Putra 6, no. 1 (September 4, 2019): 1–10. http://dx.doi.org/10.52005/rekayasa.v6i1.77.

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Komponen mur dan baut (fastener) dapat diproduksi melalui berbagai teknik, diantaranya melalui proses tempa (forging). Namun dalam suatu proses tempa dingin (cold forming) produksi mur tak lepas dari adanya kegagalan,berupa cacat retak pada permukaan. Kegagalan ini berdampak terhadap produktifitas, selain itu dapat menghambat proses yang lainnya. Pada penelitian ini cacat retak mur M14 baja karbon SWCH45K dapat diketahui secara visual pada saat inspeksi. Guna mengetahui penyebab kegagalan dilakukan analisis, dengan metode Fault TreeAnalysis (FTA).Untuk itu dilakukan pengumpulan data: sampel awal material, sampel produk mur M14, sertavariabel proses tempa dingin. Kemudian dilakukan uji karakteristik material awal untuk mengetahui sifat mekaniknya (mechanical properties) dan pengujian metalografi untuk mengetahui kualitas material awal. Selanjutnya dihitung gaya, tegangan, regangan. Hasil dari perhitungan gaya menunjukkan bahwa cacat retak disebabkan konsentrasi tegangan/stress yang tinggi pada proses pembentukan station 3 dikarenakan pojok punch tidak memiliki radius (rounding). Kesimpulan dari analisis akar masalah cacat retak pada proses pembentukan tempa dingin (cold forming) mur M14 disebabkan design tools punch tidak memiliki profil radius.

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Maeda, Shoji, Qianhui Qu, Michael J. Robertson, Georgios Skiniotis, and Brian K. Kobilka. "Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes." Science 364, no. 6440 (May 9, 2019): 552–57. http://dx.doi.org/10.1126/science.aaw5188.

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Muscarinic acetylcholine receptors are G protein–coupled receptors that respond to acetylcholine and play important signaling roles in the nervous system. There are five muscarinic receptor subtypes (M1R to M5R), which, despite sharing a high degree of sequence identity in the transmembrane region, couple to different heterotrimeric GTP-binding proteins (G proteins) to transmit signals. M1R, M3R, and M5R couple to the Gq/11 family, whereas M2R and M4R couple to the Gi/o family. Here, we present and compare the cryo–electron microscopy structures of M1R in complex with G11 and M2R in complex with GoA. The M1R-G11 complex exhibits distinct features, including an extended transmembrane helix 5 and carboxyl-terminal receptor tail that interacts with G protein. Detailed analysis of these structures provides a framework for understanding the molecular determinants of G-protein coupling selectivity.

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Do, Kien, Truyen Tran, and Svetha Venkatesh. "Semi-Supervised Learning with Variational Bayesian Inference and Maximum Uncertainty Regularization." Proceedings of the AAAI Conference on Artificial Intelligence 35, no. 8 (May 18, 2021): 7236–44. http://dx.doi.org/10.1609/aaai.v35i8.16889.

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We propose two generic methods for improving semi-supervised learning (SSL). The first integrates weight perturbation (WP) into existing “consistency regularization” (CR) based methods. We implement WP by leveraging variational Bayesian inference (VBI). The second method proposes a novel consistency loss called “maximum uncertainty regularization” (MUR). While most consistency losses act on perturbations in the vicinity of each data point, MUR actively searches for “virtual” points situated beyond this region that cause the most uncertain class predictions. This allows MUR to impose smoothness on a wider area in the input-output manifold. Our experiments show clear improvements in classification errors of various CR based methods when they are combined with VBI or MUR or both.

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Sukresno, Bambang, Rizki Hanintyo, Denny Wijaya Kusuma, Dinarika Jatisworo, and Ari Murdimanto. "THREE-WAY ERROR ANALYSIS OF SEA SURFACE TEMPERATURE (SST) BETWEEN HIMAWARI-8, BUOY, AND MUR SST IN SAVU SEA." International Journal of Remote Sensing and Earth Sciences (IJReSES) 15, no. 1 (July 2, 2018): 25. http://dx.doi.org/10.30536/j.ijreses.2018.v15.a2855.

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Variance errors of Himawari-8, buoy, and Multi-scale Ultra-high Resolution (MUR) SST in Savu Sea have been investigated. This research used level 3 Himawari-8 hourly SST, in situ measurement of buoy, and daily MUR SST in the period of December 2016 to July 2017. The data were separated into day time data and night time. Skin temperature of Himawari-8 and subskin tempertaure of MUR SST were corrected with the value of 15âˆ†Tdept"> before compared with buoy data. Hourly SST of Himawari-8 and buoy data were converted to daily format by averaging process before collocated with MUR SST data. The number of 2,264 matchup data are obtained. Differences average between Himawari-8, buoy and MUR SST were calculated to get the value of variance (Vij). Using three-way error analysis, variance errors of each observation type can be known. From the analysis results can be seen that the variance error of Himawari-8, buoy and MUR SST are 2.5 oC, 0.28oC and 1.21oC respectively. The accuracy of buoy data was better than the other. With a small variance errors, thus buoy data can be used as a reference data for validation of SST from different observation type.

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Ishibashi, Kenji, Masanori Kurihara, Ryoko Ihara, Mana Higashihara, Atsushi Iwata, and Kenji Ishii. "Detailed Assessment of 18F-THK5351 Distribution Pattern in the Midbrain: Comparison With Progressive Supranuclear Palsy and Corticobasal Syndrome." Clinical Nuclear Medicine 48, no. 10 (September 2, 2023): 841–46. http://dx.doi.org/10.1097/rlu.0000000000004815.

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Background 18F-THK5351 PET is used to image ongoing astrogliosis by estimating monoamine oxidase B levels. 18F-THK5351 preferentially accumulates around the substantia nigra (SN) and periaqueductal gray (PG) in the midbrain under healthy conditions and exhibits a “trimodal pattern.” In progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), the midbrain 18F-THK5351 uptake can be increased by astrogliosis, collapsing the “trimodal pattern.” We aimed to elucidate cases in which the “trimodal pattern” collapses in PSP and CBS. Patients and Methods Participants in the PSP (n = 11), CBS (n = 17), Alzheimer disease (n = 11), and healthy control (n = 8) groups underwent 18F-THK5351 PET. Volumes of interest (VOIs) were placed on the SN, PG, and their midpoints. The midbrain uptake ratio (MUR) was calculated to assess the trimodal pattern as follows: MUR = (VOI value on the midpoint)/(VOI value on the SN and PG). Approximately, the trimodal pattern can be identified at MUR <1 but not at MUR >1. Results Compared with the healthy control group, MUR significantly increased in the PSP (P < 0.01) and CBS (P < 0.01) groups, but was unchanged in the Alzheimer disease group (P = 0.10). In the PSP group, all patients, including 2 with mild symptoms and a short disease duration, showed MUR >1. In the CBS group, MUR varied widely. Conclusions In PSP, the trimodal pattern can collapse even in the early phase when symptoms are mild. In CBS, the trimodal pattern may or may not collapse depending on the underlying pathology.

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Zhao, Xuelian, Jose Manuel Perez-Aguilar, Felipe Matsunaga, Mitchell Lerner, Jin Xi, Bernard Selling, A. T. Charlie Johnson, Jeffery G. Saven, and Renyu Liu. "Characterization of a Computationally Designed Water-soluble Human μ-Opioid Receptor Variant Using Available Structural Information." Anesthesiology 121, no. 4 (October 1, 2014): 866–75. http://dx.doi.org/10.1097/aln.0000000000000308.

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Abstract Background: The recent X-ray crystal structure of the murine μ-opioid receptor (MUR) allowed the authors to reengineer a previously designed water-soluble variant of the transmembrane portion of the human MUR (wsMUR-TM). Methods: The new variant of water-soluble MUR (wsMUR-TM_v2) was engineered based on the murine MUR crystal structure. This novel variant was expressed in Escherichia coli and purified. The properties of the receptor were characterized and compared with those of wsMUR-TM. Results: Seven residues originally included for mutation in the design of the wsMUR-TM were reverted to their native identities. wsMUR-TM_v2 contains 16% mutations of the total sequence. It was overexpressed and purified with high yield. Although dimers and higher oligomers were observed to form over time, the wsMUR-TM_v2 stayed predominantly monomeric at concentrations as high as 7.5 mg/ml in buffer within a 2-month period. Its secondary structure was predominantly helical and comparable with those of both the original wsMUR-TM variant and the native MUR. The binding affinity of wsMUR-TM_v2 for naltrexone (Kd approximately 70 nM) was in close agreement with that for wsMUR-TM. The helical content of wsMUR-TM_v2 decreased cooperatively with increasing temperature, and the introduction of sucrose was able to stabilize the protein. Conclusions: A novel functional wsMUR-TM_v2 with only 16% mutations was successfully engineered, expressed in E. coli, and purified based on information from the crystal structure of murine MUR. This not only provides a novel alternative tool for MUR studies in solution conditions but also offers valuable information for protein engineering and structure–function relations.

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Vasylenko, Vadym. "LITERARY PUBLICATIONS OF THE UKRAINIAN ARTISTIC MOVEMENT: HISTORY, CONTENT, DIRECTION." Bulletin of Taras Shevchenko National University of Kyiv. Literary Studies. Linguistics. Folklore Studies, no. 33 (2023): 30–37. http://dx.doi.org/10.17721/1728-2659.2023.33.05.

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The article analyzes the important literary publications of the Ukrainian Artistic Movement (MUR), devoted to artistic, literary-critical, art history issues (in particular, the collections "MUR", MUR's аlmanac, "Arсh"). The issues of history, content, and direction of these publications are investigated, each of which is considered as a kind of integrity and is considered in the context of the literary activity of the MUR. The historical, cultural and socio-political prerequisites of MUR's publications, their ideological and aesthetic foundations, and functions are clarified. It is argued that the MUR's literary projects reflect general culture and social moods and trends, ideological and aesthetic changes in the Ukrainian emigration literary process of the late 1940s, that these publications present the most important ideas and works of that time. It is noted that the priority of the three Collections of Literary and Artistic Issues "MUR" was programmatic, and the MUR аlmanac aimed to reflect artistic diversity of literary life, in particular stylistic. The main attention is devoted to the "Arch" as an outstanding and unique phenomenon in the history of Ukrainian literary and literary-critical thought, in particular, the history of its creation, changes in editorial policy are revealed, its assessments are recorder in the views of contemporaries. Periodicals published under the auspices of the MUR had a great influence on the cultural and literary process of the late 1940s, contributing, in particular, to the consolidation of creative efforts, the duration and continuity of Ukrainian modernists and Europeanists literary trends. Memoirs, letters, papers of the creators and members of the MUR, in particular, Yuri Sherekh (Shevelov), Ulas Samchuk, Gregory Kostyuk, Yuri Lavrinenko and other became the source base for the study.

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Pearson, D., N. Preston, A. Al-Naimi, and C. Smith. "Establishing meter under registration on domestic premises with roof tanks." Water Practice and Technology 14, no. 1 (December 11, 2018): 126–36. http://dx.doi.org/10.2166/wpt.2018.113.

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Abstract The Public Authority for Electricity and Water in Oman carried out an initial estimate of legitimate domestic night consumption (LDNC) based on an assessment of night consumption surveys of over 1,500 premises. However, no allowance for meter under-registration (MUR) had been applied in the assessment. This paper reports on a study to identify MUR in Oman, which can be applied to the results of the survey for LDNC. All premises in Oman are required to have a roof tank in order for customers to maintain their supply in the case of mains water supply interruptions. Regulations require that the roof tanks provide at least two days' storage. It is believed that roof tanks could have a significant impact on MUR due to the long ‘tails’ generated by the operation of the ball valve controlling the refilling of the roof tank. It was therefore decided that a study should be carried out to review the main drivers for MUR and the likely level of MUR to be expected in Oman, particularly at low flows such as those experienced at night time when a single toilet is flushed. In regards to the sample of properties included in the MUR survey, it was suspected that in the case of apartment blocks, the revenue meters will normally be located after the roof tank, in which case the roof tank will not influence MUR. This study sought to confirm this. Half the premises were fitted with an unmeasured flow reducer on a bypass so that the potential of such devices to reduce MUR could be investigated. Oman has continuous water supply. There were no supply interruptions during the study. The paper describes details of the plumbing arrangements developed for the study and the results established as part of the programme. It also takes the opportunity to report on the level of daily and night consumption experienced on the study area.

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Gressgård, Randi. "Sterk mur, svak suverenitet." Agora 29, no. 02-03 (October 19, 2011): 338–48. http://dx.doi.org/10.18261/issn1500-1571-2011-02-03-28.

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Fonn, Maria Kjos. "En mur av muligheter." Samtiden 125, no. 03 (October 11, 2017): 50–53. http://dx.doi.org/10.18261/issn1890-0690-2017-03-10.

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Louguet, Isabelle. "Le Mur comme symbole." La chaîne d'union N° 69, no. 3 (January 3, 2014): 78–83. http://dx.doi.org/10.3917/cdu.069.0078.

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Doucet, Caroline. "Au pied du mur." La Cause Du Désir N° 97, no. 3 (2017): 147. http://dx.doi.org/10.3917/lcdd.097.0147.

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Ferenczi, George, and Olivier Apert. "Le Mur intérieur, 1991." Les Temps Modernes 625, no. 4 (2003): 264. http://dx.doi.org/10.3917/ltm.625.0264.

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Bove, Laurent. "Vivre contre un mur." Multitudes 33, no. 2 (2008): 111. http://dx.doi.org/10.3917/mult.033.0111.

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Dicale, Bertrand, and Pascal Cordereix. "Le mur du son." Revue de la BNF 55, no. 2 (2017): 9. http://dx.doi.org/10.3917/rbnf.055.0009.

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Bertrand, Dominique. "Le mur du temps." Insistance 3, no. 1 (2007): 15. http://dx.doi.org/10.3917/insi.003.0015.

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Journal articles on the topic 'Mur'

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