Academic literature on the topic 'Muricatacin'

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Journal articles on the topic "Muricatacin"

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Wang, Wencong, Rui Zhang, Jinxing Wang, Jun Tang, Mingan Wang, and Yu Kuang. "Antitumour Activity of Muricatacin Isomers and its Derivatives in Human Colorectal Carcinoma Cell HCT116." Anti-Cancer Agents in Medicinal Chemistry 20, no. 2 (2020): 254–63. http://dx.doi.org/10.2174/1871520619666191115111032.

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Background and Purpose: Colorectal cancer is one of the leading causes of cancer-related death in elderly people. The natural product muricatacin is an important member of the γ-lactone family, and it has exhibited antitumour activity in multiple cancer cell lines; however, the antitumour activities of muricatacin stereoisomers and their derivatives in colorectal cancer cells have not yet been systematically explored. Methods: The colorectal carcinoma cell line HCT116 was investigated in this study. Cell proliferation was assessed by MTT assay or crystal violet staining. Cell cycle arrest and
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Dong, Hong-Bo, Ming-Yan Yang, Bin Liu, and Ming-An Wang. "Concise stereoselective total synthesis of (+)-muricatacin and (+)-epi-muricatacin." Journal of Asian Natural Products Research 16, no. 8 (2014): 847–53. http://dx.doi.org/10.1080/10286020.2014.916695.

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Makabe, Hidefumi, Akira Tanaka, and Takayuki Oritani. "Synthesis of (–)-Muricatacin." Bioscience, Biotechnology, and Biochemistry 57, no. 6 (1993): 1028–29. http://dx.doi.org/10.1271/bbb.57.1028.

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Popsavin, Velimir, Sanja Grabez, Ivana Krstic, Mirjana Popsavin, and Dejan Djokovic. "A formal synthesis of (+)-muricatacin from D-xylose." Journal of the Serbian Chemical Society 68, no. 11 (2003): 795–804. http://dx.doi.org/10.2298/jsc0311795p.

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A multistep route towards the aldehydo-lactone 19, the final chiral precursor in a new stereospecific synthesis of (+)-muricatacin, has been developed starting from D-xylose. The key step of the synthesis involves an E-selective Wittig olefination of the lactol 6 with methoxycarbonylmethylidene triphenylphosphorane, followed by successive catalytic reduction and ?-lactonisation processes. Subsequent selective functional groups interconver- sions furnished the key six-carbon intermediate 19, which can be converted into the (+)-muricatacin via a three-step sequence already described in the chemi
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González, Maria, Zoila Gándara, Berta Covelo, Generosa Gómez, and Yagamare Fall. "Total synthesis of (−)-muricatacin." Tetrahedron Letters 52, no. 45 (2011): 5983–86. http://dx.doi.org/10.1016/j.tetlet.2011.08.160.

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Prasad, Kavirayani R., and Vasudevarao Gandi. "Facile enantiospecific synthesis of (−)-muricatacin." Tetrahedron: Asymmetry 19, no. 22 (2008): 2616–19. http://dx.doi.org/10.1016/j.tetasy.2008.11.004.

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Baussanne, Isabelle, Oliver Schwardt, Jacques Royer, Marianne Pichon, Bruno Figadère, and André Cavé. "Synthesis of aza-muricatacin: an analogue of the bioactive muricatacin an acetogenin of Annonaceae." Tetrahedron Letters 38, no. 13 (1997): 2259–62. http://dx.doi.org/10.1016/s0040-4039(97)00292-x.

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Chang, Sue-Wen, Chiu-Yong Hung, Hung-Hsin Liu та Biing-Jiun Uang. "Enantioselective synthesis of γ-lactones from thioglycolic acid: Syntheses of (−)-muricatacin and 5-epi-(−)-muricatacin". Tetrahedron: Asymmetry 9, № 3 (1998): 521–29. http://dx.doi.org/10.1016/s0957-4166(98)00007-x.

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Cooze, Christopher, Amarender Manchoju, and Sunil Pansare. "Synthesis of (–)-Muricatacin and (–)-(R,R)-L-Factor Involving an Organocatalytic Direct Vinylogous Aldol Reaction." Synlett 28, no. 20 (2017): 2928–32. http://dx.doi.org/10.1055/s-0036-1590858.

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Concise syntheses of the polyketide natural product (–)-muricatacin and (–)-(R,R)-L-factor (natural product enantiomer) were achieved in four steps by employing an organocatalytic asymmetric direct vinylogous aldol reaction of γ-crotonolactone and suitable aliphatic aldehydes as the key step.
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Somfai, Peter. "An enantiospecific total synthesis of (+)-muricatacin." Journal of the Chemical Society, Perkin Transactions 1, no. 7 (1995): 817. http://dx.doi.org/10.1039/p19950000817.

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Dissertations / Theses on the topic "Muricatacin"

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Bojana, Srećo Zelenović. "Dizajn, sinteza i antiproliferativna aktivnost prirodnih citotoksičnih laktona i analoga." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2013. https://www.cris.uns.ac.rs/record.jsf?recordId=83673&source=NDLTD&language=en.

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Ostvarene su vi&scaron;efazne sinteze prirodnih citotoksičnih laktona (+)-murikatacina (<strong>1</strong>),(&ndash;)-murikatacina (ent-<strong>1</strong>) i (+)-goniofufurona (<strong>2</strong>), kao i njihovih novih analoga (<strong>3a</strong>,&nbsp; <strong>4</strong>,<strong>5</strong>,&nbsp; <strong>6</strong>,&nbsp; <strong>7</strong>,&nbsp; <strong>8</strong>,&nbsp; <strong>9</strong>,&nbsp; ent-<strong>7&nbsp;</strong>i ent-<strong>9</strong>), polazeći iz&nbsp; D-ksiloze ili iz&nbsp; D-glukoze. Ispitana je&nbsp; in vitrocitotoksična aktivnost sintetizovanih prirodnih proizvoda i ana
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Pichon, Stainmesse Marianne. "Etude de la synthese d'analogues azotes d'acetogenines d'annonaceae l'aza-muricatacine et l'aza-solamine (doctorat : pharmacochimie)." Paris 11, 1998. http://www.theses.fr/1998PA114839.

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Ferrié, Laurent. "Developpement de métathèses d'oléfines chimiosélectives : application à la synthèse de produits naturels biologiquement actifs." Paris 6, 2008. http://www.theses.fr/2008PA066043.

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Durant la dernière décennie, la métathèse d’oléfines catalysée par les métaux de transition est devenue l’une des plus puissantes transformations organométalliques, permettant la formation de liaisons carbone-carbone en synthèse organique. En particulier, les réactions de fermeture de cycle par métathèse ou de métathèse croisée ont été très largement étudiées. Grâce au développement de catalyseurs robustes au ruthénium par Grubbs et al. , la métathèse est devenue un puissant outil dans la synthèse totale de produits naturels biologiquement actifs. En particulier les macrolactones, que l’ont pe
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Gandi, Vasudeva Rao. "Enantioselective Synthesis Of Didemniserinolipid, Cladospolides, Aspercyclide And Muricatacin." Thesis, 2010. http://hdl.handle.net/2005/1893.

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The thesis entitled “Enantioselective synthesis of didemniserinolipid, cladospolides, aspercyclide and muricatacin” is divided into three chapters. First chapter of the thesis deals with the formal total synthesis both enantiomers didemniserinolipid B from L-(+)-tartaric acid. Fused bicyclic acetals containing 6,8-dioxabicyclo[3.2.1]octane structural unit are wide spread in bio active natural products. Didemniserinolipids A-C possessing similar framework were isolated from a methanol extract of Didemnum sp., and some of the analogous compounds were found to be cytotoxic against P388, A549, and
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Tsai, Shih-Hung, and 蔡世鴻. "synthesis of hydroxylated muricatacin analogs related to squamocin." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/22398929345712140974.

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碩士<br>高雄醫學院<br>天然藥物研究所<br>87<br>Two hydroxylated muricatacin analogs were synthesized in nine steps and the overall yield of 3 and 5 are 5.5% and 1.7%, respectively. This synthesis includes the addition of the starting aldehyde with acetylide, hydrogenation of the resulting propargylic alcohol using nickel boride as a catalyst, protection of the secondary hydroxyl group, deprotection of the primary hydroxyl group, oxidation of the primary alcohol to an aldehyde, addition of the aldehyde with vinyl magnasium bromide, orthoester Claisen rearrangement to the g,d-unsaturated ester, Sharpless asymm
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Book chapters on the topic "Muricatacin"

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Doran, Robert. "Asymmetric Synthesis of Both Enantiomers of a δ-Lactone Analogue of Muricatacin". У Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_3.

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