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Dissertations / Theses on the topic 'Muscle-derived'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Craig, Laura A. "Differentiation of multipotent skin derived precursor cells into skeletal muscle." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80245.

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The potential use of stem cells for therapy depends on our ability to optimize differentiation conditions to best take advantage of their multipotentiality. Skin derived precursor cells (SKPs) are recently described adult stem cells that have been shown to differentiate into both neuronal and mesodermal cell types in vitro. We asked specifically whether they could be induced to differentiate into skeletal muscle. An accurate assay for detecting skeletal muscle was first developed, using RT-PCR, immunocytochemistry and Western blotting. We then used traditional differentiation methods, a

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2

Marks, Theodore N. "Calcium currents in the A7r5 smooth muscle-derived cell line." Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1054919224.

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3

AGUIARI, Paola. "High Glucose Induces Adipogenic Differentiation of Muscle-Derived Stem Cells." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2388681.

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Regeneration of mesenchymal tissues depends on a resident stem cell population, that in most cases remains elusive in terms of cellular identity and differentiation signals. We here show that primary cell cultures derived from adipose tissue or skeletal muscle differentiate into adipocytes when cultured in high glucose. High glucose induces ROS production and PKCβ activation. These two events appear crucial steps in this differentiation process that can be directly induced by oxidizing agents and inhibited by PKCβ siRNA silencing. The differentiated adipocytes, when implanted in vivo, fo

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4

Lightfoot, Adam Paul. "Skeletal muscle as an endocrine organ : impact of muscle-derived cytokines and extracellular heat shock proteins." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569584.

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Skeletal muscle wasting in the critically ill with sepsis is intrinsically linked to the elevations in circulating levels of cytokines characteristic to systemic inflammation and this effect may be exacerbated in older people. A key cytokine in this hyper- inflammatory state is TNF -a. Muscle is a plastic organ which adapts to stresses, including systemic inflammation in a number of ways, including the increased expression of Heat Shock Proteins (HSPs) and increased expression and release of cytokines (myokines). The release of HSPs by non-muscle cells has been described, but the extracellular

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5

Rudnicki, Michael Anthony. "Embryonal carcinoma derived cardiac muscle studies in gene expression and differentiation." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5167.

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6

Yeo, Wendy Wai Yeng. "Differentiation of skeletal muscle-derived stem cells into beta pancreatic lineage." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS091.

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Le diabète de type 1 (DT1) est caractérisé par des niveaux élevés de glucose en raison de la destruction des cellules ß pancréatiques sécrétrices d'insuline. Cependant, les thérapies actuelles de remplacement des cellules bêta du pancréas impliquant la transplantation d'îlots pancréatiques sont techniquement difficiles et limitées par la disponibilité de don d'organes. Bien que les cellules souches embryonnaires et les cellules souches pluripotentes induites soient intensément étudiées, aucune de ces deux sources de cellules souches ne peut être utilisée directement sans le risque de développe

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7

Styhler, Angela. "Proliferative response of airway smooth muscle cells to macrophage-derived products." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22812.

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Brown Norway rats show increased airway smooth muscle content following repeated allergen challenges. Macrophages synthesize many growth factors in vitro which potentially stimulate proliferation of airway smooth muscle cells. Leukotriene C$ sb4$, an important mediator of allergic airway responses, can stimulate macrophages to release platelet-derived growth factor (PDGF) which is a potent stimulator of proliferation. The purpose of this study was to investigate the role of the macrophage in the proliferative response of airway smooth muscle cells leading to airway remodelling. Macrophages wer

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8

Collins, P. "Endothelium-derived relaxant factor and calcium fluxes in vascular smooth muscle." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597863.

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9

Carnagarin, Revathy. "Pigment Epithelium-derived Factor and Insulin Crosstalk in Skeletal Muscle Biology." Thesis, Curtin University, 2017. http://hdl.handle.net/20.500.11937/59666.

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PEDF is an important regulator of skeletal muscle metabolism, in particular the insulin–dependent metabolic processes. The attenuation of PEDF signalling is an effective approach to achieve better control over the insulin resistance of metabolic disorders and the PEDF-insulin antagonistic cross talk involved in the modulation of skeletal muscle biology could be an effective strategy to achieve controlled bone formation counteracting the PEDF-induced heterotrophic ossification.

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10

O'Leary, Mary Frances. "The role of adipose and skeletal muscle derived cytokines in primary human myogenesis : implications for ageing skeletal muscle." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8089/.

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Sarcopenia is the age-related loss of skeletal muscle mass and function; inflammation is thought to be one aetiological factor in its development. Adipose tissue accumulates with advancing age and adipose-derived cytokines (adipokines) contribute to inflammaging. Skeletal muscle myogenesis is one adaptaive mechanism by which skeletal muscle mass is sustained throughout the human lifespan. The effect of the adipose inflammatory milieu on such myogenesis is unknown, as is the relative importance of its constituent adipokines to myogenesis. This work demonstrates that conditioned medium generated

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11

Shelton, Michael L. "Generation and Characterization of Human Embryonic Stem Cells-Derived Skeletal Muscle Progenitors." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37973.

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The long-term treatment of injured, aging, or pathological skeletal muscle using stem cell therapy requires an abundant source of skeletal muscle progenitors (SMP) that are capable of self-replenishment. While adult SMPs—known as satellite cells and marked by PAX7 expression—can be collected from healthy donors, these satellite cells have limited replication potential once extracted, and may have difficulties providing sufficient numbers for therapy. Therefore, we sought to utilize the near-unlimited replication potential of human embryonic stem cells (hESC) to generate large quantities of SMP

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12

Glass, Graeme Ewan. "Promoting fracture repair by inflammation-mediated recruitment of muscle derived stromal cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6065.

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High energy open fractures are prone to delayed and non-union, necessitating secondary reconstruction or amputation and are associated with prolonged pain, disability and loss of income. Current strategies for accelerating healing require the addition of high concentrations of bone morphogenetic proteins or ex vivo expansion and/or viral transduction of autologous, marrow-derived stem cells for re-implantation. It is established that prompt cover with vascularised tissue is required to prevent bony infection. Coverage with muscle improves healing time and union strength in an experimental mode

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13

Folestad, Erika Bergsten. "Studies of the novel PDGFs, focusing on PDGF-D /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-770-7/.

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14

Bonello, Michelle Rita Medical Sciences Faculty of Medicine UNSW. "Transcriptional regulation of platelet-derived growth factor receptor-?? in vascular smooth muscle cells." Awarded by:University of New South Wales. School of Medical Sciences, 2005. http://handle.unsw.edu.au/1959.4/23333.

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Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of vascular occlusive disorders such as atherosclerosis and restenosis, in part due to its regulation of smooth muscle cell (SMC) phenotype. The molecular mechanisms regulating the expression of PDGF-receptor-?? (PDGF-R-??), which binds all known dimeric forms of PDGF except PDGF-DD, are poorly understood. Here it is demonstrated that PDGF-R-?? protein and transcriptional regulation in SMCs is under the positive regulatory influence of the zinc finger nuclear protein, Sp1. An atypical G-rich Sp1-binding element from

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15

Liu, Yanxia Medical Sciences Faculty of Medicine UNSW. "Mechanisms regulating platelet-derived growth factor-D transcription in vascular smooth muscle cells." Awarded by:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/43372.

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Platelet-derived growth factor D-chain (PDGF-D) is the newest member of the PDGF family of mitogens and chemo-attractants; it is expressed in a wide variety of cell types, including vascular smooth muscle cells (SMCs). The molecular mechanisms regulating PDGF-D transcription are unknown. Here I investigated the effects of angiotensin II (ATIl) and IL-1 beta on the transcription of PDGF-D and changes in vascular SMCs phenotype. Primer extension analysis mapped a single transcriptional start site to the ccAG CGC motif of PDGF-D promoter. Several potential transcription factor binding sites such

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16

Ūsas, Arvydas. "Regeneration of injured bone and articular cartilage using mouse muscle derived stem cells." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110428_084507-21298.

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The objective of the study: To characterize stem cells isolated from mouse skeletal muscle and evaluate their regenerative potential to repair injured bone and articular cartilage in a mouse and rat animal model. The aims of the study: 1. Isolate MDSCs from mouse skeletal muscle, to determine their phenotypic characteristics and differentiation potential in vitro. 2. Evaluate osteogenic and chondrogenic regeneration capacity of MDSCs genetically engineered to express bone morphogenetic protein 4 (BMP4). 3. Evaluate osteogenic and chondrogenic differentiation potential of MDSCs-expressing BMP4

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17

Carlqvist, K. H. "The potential of muscle-derived progenitors on titanium scaffolds in bone regenerative applications." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1301768/.

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Muscle-derived cells (MDCs) are a heterogeneous population consisting of cells that can undergo myogenic differentiation; however, it has emerged that not all MDCs are restricted to the myogenic lineage. This discovery may have many implications; for example, MDCs may be a suitable alternative source of osteogenic cells for bone repair. The currently accepted treatment for bone repair, bone grafting, is often associated with small amount of obtainable bone. Much of the work published regarding the differential potential of MDCs has not, to date, focused on the osteogenic pathway and even fewer

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18

Jacobs, Leila Susan. "Role of sphingolipids in regulation of vascular smooth muscle-derived A7r5 cell proliferation." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1057078196.

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19

Martin, Neil Richard William. "A tissue engineered human skeletal muscle model for use in exercise sciences." Thesis, University of Bedfordshire, 2012. http://hdl.handle.net/10547/294280.

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Skeletal muscles are composed of thousands of muscle fibres (muscle cells), densely packed together in parallel and surrounded by connective tissue sheaths. These fibres are multinuclear in nature, which allows for the control and regulation of the highly organised, protein rich cellular interior. The primary function of skeletal muscle is to produce force, which allows for movement to occur or posture to be maintained, and the regulation of this function is in turn reliant on the expression of specific genes and proteins. Skeletal muscle exhibits a high degree of plasticity, and can adapt in

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20

Iyer, Dharini. "Generation of epicardium and epicardium-derived coronary-like smooth muscle cells from human pluripotent stem cells." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708997.

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21

Clow, Charlene. "The Role of Brain-Derived Neurotrophic Factor (BDNF) in Postnatal Muscle Development and Regeneration." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28714.

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In adult skeletal muscle, brain-derived neurotrophic factor (BDNF) is expressed in a reserve population of myogenic progenitors known as satellite cells. Previous studies in our laboratory have shown that siRNA-mediated depletion of BDNF results in precocious differentiation of myoblasts in culture, suggesting a role in regulation of myogenic differentiation (J. Neuroscience, 2006). In order to functionally address the role of BDNF in muscle satellite cells and regeneration in vivo, we employed a Cre/Lox approach to generate a mouse in which BDNF is specifically depleted from skeletal muscle c

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22

Swaminathan, Ganesh. "Evaluation Of Adult Stem Cell Derived Smooth Muscle Cells For Elastic Matrix Regenerative Repair." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1462209321.

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23

Ruan, Travis. "Identification of Terminal Differentiation Enhancers in Human Embryonic Stem Cell Derived Skeletal Muscle Cells." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27257.

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Skeletal myogenesis is a tightly coordinated process resulting from the temporal expression of signalling cascades that specify myogenic cell fate. Identification of signalling pathways and small molecules that can modulate this developmental process, continues to be an active area of research. Utilising the pluripotent nature of human embryonic stem cells (hESC) and combined with next generation sequencing, we demonstrate our in vitro skeletal muscle differentiation system accurately recapitulate major skeletal muscle developmental process. We show myotubes formation can be further enhanced u

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24

Arrigoni, E. "ADIPOSE-DERIVED STEM CELLS (ASCS) FOR FUTURE CELLULAR THERAPIES IN MUSCLE-SKELETAL TISSUES REGENERATION." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/170261.

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Every year several patients have to deal with bone tissue loss due to trauma or diseases. Bone tissue engineering aims to restore or repair musculoskeletal disorders through the development of bio-substitutes that require the use of cells and scaffolds which should possess both adequate mechanical properties and interconnecting pores to allow cellular infiltration, graft integration and vascularization. The ideal cell for tissue engineering should possess a potential plasticity with the ability to functionally repair the damaged tissue, and it should be available in large amount. Mesenchymal s

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25

Harutiun, Minas Nalbandian Geymonat. "Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265184.

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京都大学<br>新制・課程博士<br>博士(医学)<br>甲第23412号<br>医博第4757号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)特定拠点教授妻木範行, 教授戸口田淳也, 教授松田秀一<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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26

Oredsson, Sven. "Reperfusion injury in skeletal muscle with special reference to oxygen-derived free radicals as mediators /." Lund : Dept. of Surgery, Helsingborg Hospital, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39056318.html.

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27

El-Haroun, Hala Mohamed El-Sayed. "The role of COX-2 derived prostanoids in regulating pulmonary artery smooth muscle cells functions." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415551.

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28

Alqudah, Mohammad. "Characterization of the neurotrophic factor Brain-Derived Neurotrophic Factor (BDNF) in intestinal smooth muscle cells." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3095.

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Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of secreted proteins, which include in addition to BDNF, nerve growth factor (NGF) and neurotrophin 3-6 (NT-3-6). BDNF mediates its functions by activating two cell surface receptors, pan-neurotrophin receptor (P75NTR) and tropomyosin-related kinase B (TrkB) and their downstream intracellular cascades. BDNF is best known for its role in neuronal survival, regulation of neuronal differentiation, migration and activity-dependent synaptic plasticity. However, BDNF is widely expressed in non-neuronal tissues as well. The l

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29

Knapp, Amy Elizabeth. "Is myocyte-derived VEGF in adult mice required for normal skeletal muscle structure and function?" Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3360169.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed July 28, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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30

Buetow, Bernard Steven. "Platelet-derived growth factor receptor beta and platelet-derived growth factor B-chain in vascular reaction to injury and angiogenesis /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/6317.

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31

Alqahtani, K. M. A. "Comparison of the multi-lineage differentiation ability of craniofacial and limb skeletal muscle derived progenitor cells." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1349361/.

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Comparison of multi-lineage differentiation ability of craniofacial skeletal muscle and limb muscle progenitor cells Alqahtani, K, Wall, I, Lewis, M.P. Craniofacial Skeletal Muscles (CSkM), including masticatory muscles, have a number of properties that distinguish them from the majority of skeletal muscles. They have different embryological origin from other muscles; they have better regenerative abilities compared to other body muscles including limb muscles. In addition, they may have easier access for biopsies. These findings suggest that CSkM may contain highly active multipotent progenit

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32

Abdoli, Yazdi Sahar. "The role of integrin-linked kinase in platelet-derived growth factor stimulated vascular smooth muscle cell migration." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27570.

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Background: Vascular smooth muscle cell migration and accumulation in response to growth factors extensively contribute to the development of intimal thickening within the vessel wall. Cumulative evidence has shown that actin cytoskeleton polymerization and rearrangement are critical steps during cellular spreading and migration. Integrin-linked kinase, an intracellular serine/threonine kinase, is a cytoplasmic interactor of integrin beta-1 and beta-3 receptors and has been reported to regulate cell-cell and/or cell-extracellular matrix interaction, cell contraction, extracellular matrix modif

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33

Hasegawa, Yoshinori, Masahiro Sokabe, Mitsuo Sato, et al. "STIM1 Regulates Platelet-Derived Growth Factor-Induced Migration and Ca2+ Influx in Human Airway Smooth Muscle Cells." Thesis, PLOS ONE, 2012. http://hdl.handle.net/2237/18819.

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34

Merrison, Dr Andria Frances Alexandra. "Human adult bone marrow-derived mesenchymal stem cells: myogenic potential and the factors influencing skeletal muscle differentiation." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492624.

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Thousands of people in the United Kingdom suffer from primary muscle disease and secondary dysfunction is an increasingly recognised cause of muscle-related morbidity. Patients suffering from these conditions face significant disability and few treatment options. Much excitement has surrounded the therapeutic implications of stem cell research, including potential treatment for muscle disease.

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35

Waldron, Gareth James. "A study of the influence of endothelium-derived changes in smooth muscle membrane potential on vascular tone." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241563.

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36

Henning, Beverley Jane. "Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity." Thesis, Liverpool John Moores University, 2015. http://researchonline.ljmu.ac.uk/4346/.

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PW1+/Pax7– skeletal muscle-derived interstitial progenitor cells (PICs) are myogenic in vitro, efficiently contribute to skeletal muscle regeneration in vivo, and are self-renewing in vivo whilst also giving rise to satellite cells (Mitchell et al. 2010). They have previously been identified in the mouse and pig and are bi-potent forming both smooth and skeletal muscle (Mitchell et al. 2010, Lewis et al. 2014). This study characterised murine PICs for stem cell properties of self-renewal, clonogenicity and multipotency. Furthermore, PW1 expression was assessed in cardiac tissue, and in an isol

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37

Kocharyan, Avetik. "Derivation and Characterization of Pax7 Positive Skeletal Muscle Precursor Cells from Control and HGPS-derived induced Pluripotent Stem Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37517.

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Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder associated with premature aging in various tissues and organs of the afflicted individuals, including accelerated skeletal muscle atrophy. Classical HGPS manifests due to single-base substitution in the LAMNA gene which encodes Lamin A/C proteins. As a result of the mutation, a truncated form of Lamin (known as Progerin) is produced which undergoes persistent farnesylation during post-translational modification. Accumulation of Progerin in the nucleus has been linked to various cellular abnormalities including abnormal nucl

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Tan, Yu Yin Nicole Medical Sciences Faculty of Medicine UNSW. "Gene expression during activation of smooth muscle cells." Publisher:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/43615.

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Cardiovascular disease, which involves the cardiac, cerebrovascular and peripheral vascular system, is the major cause of morbidity and mortality in the western world. Changes in the vascular microenvironment trigger cascades of molecular events involving altered signaling, transcription and translation of a gene. The aim of this thesis was to increase our understanding on the molecular regulation of activated vascular smooth muscle cells. The first study looking at PDGF-D expression provides new insights into the regulatory mechanisms controlling the phosphorylation of Sp1. Studies performed

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Reidinger, Amanda Zoe. "Changes in Passive and Dynamic Mechanical Environments Promote Differentiation to a Contractile Phenotype in Vascular Smooth Muscle Cells." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-dissertations/230.

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Every year, 400,000 coronary artery bypasses (CABG) are performed in the United States. However, one third of all patients who need a CABG cannot undergo the procedure because of the lack of suitable autologous blood vessels. Both synthetic and tissue engineered vascular grafts have been used clinically for vascular grafts or other surgical applications, but no small- diameter engineered vessels have yet been successfully used for CABG. The success of vascular tissue engineering is strongly dependent on being able to control tissue contractility and extracellular matrix (ECM) production to ach

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Morash, Taryn May. "Investigating the regenerative effects of adipose-derived mesenchymal stem cell conditioned media on sarcopenic and progeric skeletal muscle." Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/80706/.

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Ageing, defined as the progressive deterioration of molecular, cellular, tissue and whole organism function, is a primary risk factor for numerous diseases, such as cardiovasculature disease, neurodegeneration and cancer. In recent years, advances in our knowledge of key determinant mechanisms that underpin ageing decline, drives the notion that these features can be attenuated and targeted therapeutically, enabling elderly individuals to experience an enhanced quality of life into advanced old age. Sarcopenia comprises the age-related loss of muscle mass, quality and function and contributes

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Vickers, Scott M. (Scott Mitchell) 1978. "Expression of alpha-smooth muscle actin and contraction of collagen-glycosaminoglycan scaffolds by cells derived from canine synovium." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/89917.

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AZZONI, EMANUELE. "A novel population of embryonic endothelial derived progenitors contributes to multiple mesodermal lineages during development and muscle regeneration." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/20179.

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Several investigators have reported the isolation of vessel-associated multipotent mesodermal progenitors from diverse dissociated and cultured embryonic, fetal, perinatal and adult tissues. Despite the increasingly recognized medical value of these progenitor cells, among which are mesoangioblasts, these indirect extraction methods have precluded the understanding of their native identity, tissue distribution and frequency. We addressed this question by using a genetic lineage tracing approach. We labelled embryonic VE-Cadherin+ endothelial cells in the E8.5-E9 time window. At embryonic, foe

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Braitsch, Caitlin M. "The role of Pod1/Tcf21 in epicardium-derived cells in cardiac development and disease." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367925962.

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Dechert, Melissa A. "Signaling through p21-activated kinase 1 in airway smooth muscle /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3090865.

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45

So, Hon-fai, and 蘇漢暉. "Age-dependent effects of mitochondrial function in skin fibroblasts and skeletal muscle derived from a Parkinsonian LRRK2 R1441G knockinmouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50162846.

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Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra of the brain. The pathogenesis and etiology of PD are unclear. Mitochondrial dysfunction occurs in PD, causing a decrease in complex I activity in postmortem brain, and exacerbating reactive oxygen species production and ATP deficiency contributing to neuronal cell death. Mutation of leucine-rich-repeat kinase 2 (LRRK2) gene is the most common genetic factor identified in both familial and sporadic PD cases. Several mutations in LRRK2 have be

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46

Imamura, Hirotoshi. "Transdifferentiation of bone marrow-derived endothelial progenitor cells into the smooth muscle cell lineage mediated by tansforming growth factor-β1". Kyoto University, 2010. http://hdl.handle.net/2433/120926.

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Erratico, S. A. "SVILUPPO DI UN MODELLO SPERIMENTALE PER LO STUDIO DEI FATTORI DEGENERATIVI CHE INDUCONO IL DIFFERENZIAMENTO ADIPOCITARIO DI CELLULE STAMINALI MESENCHIMALI." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/169910.

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In adult tissues, somatic stem cells represent a cell reservoir involved in physiological or pathological cell replacement within healthy or damaged tissue. Thanks to specific molecular or physical signals of the microenvironment, homeostasis process is guaranteed inside stem cell niches. Factors deriving from pathological events induce a shift in stem cell behaviour to cell differentiation, in order to reconstitute cell populations lost in the damaged tissue. In several myopathies, chronic inflammation is a part of pathological process that causes fibrotic infiltrations and adipose depositio

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Gu, Wenduo. "Smooth muscle differentiation from human umbilical cord derived mesenchymal stem cells : miRNA-involved mechanism and potential application for vascular tissue engineering." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/smooth-muscle-differentiation-from-human-umbilical-cord-derived-mesenchymal-stem-cells(a4f2009e-1f83-484b-b1d9-18a2babf71af).html.

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Tissue engineered vascular grafts with long term patency are in great need in the clinics. An accessible source of human smooth muscle cell (SMC) is important for constructing functional vascular grafts. Human mesenchymal stem cells from the umbilical cord (UCMSCs) exhibit multi-lineage differentiation abilities, including the potential to differentiate towards vascular lineages such as SMCs. MicroRNAs (miRNAs) are short non-coding regulatory RNAs. They widely participate in regulation of stem cell differentiation and may play an important role in SMC differentiation. Understanding how to gene

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Munchhof, Amy M. "The role of neurofibromin in regulation of endothelial cell and vascular smooth muscle cell functions in response to neurofibroma derived growth factors." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3330808.

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Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007.<br>Title from home page (viewed on Jul 23, 2009). Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 5925. Adviser: David A. Ingram.

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Li, Xiang. "Mitochondrial transfer from induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial and smooth muscle cells attenuates oxidative stress-induced injury." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/58260.

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Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by persistent airflow limitation that is not fully reversible and is usually caused by cigarette smoke (CS). The disease is predicted to be the fourth leading cause of death by 2030, but none of the currently available treatments can alleviate the progressive decline in lung function. Mesenchymal stem cells (MSCs) are fibroblast-like multipotent stem cells that can be isolated from various tissues such as bone marrow (BM-MSCs). Despite numerous reports of their efficacy in COPD-related pre-clinical mod

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