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Relevant bibliographies by topics / Musculoskeletal Diseases, therapy

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Academic literature on the topic 'Musculoskeletal Diseases, therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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Journal articles on the topic "Musculoskeletal Diseases, therapy"

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Kozlova, Kozlova I. V., Kudishina M. M. Kudishina, Bykova A. P. Bykova, and Krylova Yu S. Krylova. "Pathology of the musculoskeletal system in inflammatory bowel diseases." Therapy 7_2021 (October 15, 2021): 50–57. http://dx.doi.org/10.18565/therapy.2021.7.50-57.

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Talbot, K. "Musculoskeletal diseases: from complex genetics to therapy." Current Opinion in Pharmacology 3, no. 3 (June 2003): 277–79. http://dx.doi.org/10.1016/s1471-4892(03)00044-4.

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Karateev, Andrei Evgenyevich. "Combination therapy for pain in musculoskeletal diseases." Neurology, neuropsychiatry, Psychosomatics, no. 4 (December 15, 2012): 76. http://dx.doi.org/10.14412/2074-2711-2012-427.

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Belluzzi, Elisa, Assunta Pozzuoli, and Pietro Ruggieri. "Musculoskeletal Diseases: From Molecular Basis to Therapy." Biomedicines 12, no. 1 (December 22, 2023): 32. http://dx.doi.org/10.3390/biomedicines12010032.

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Huang, Wan, and Gwendolyn Sowa. "Biomarker Development for Musculoskeletal Diseases." PM&R 3 (June 2011): S39—S44. http://dx.doi.org/10.1016/j.pmrj.2011.04.023.

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Evans, Christopher H., Steven C. Ghivizzani, James H. Herndon, and Paul D. Robbins. "Gene Therapy for the Treatment of Musculoskeletal Diseases." Journal of the American Academy of Orthopaedic Surgeons 13, no. 4 (July 2005): 230–42. http://dx.doi.org/10.5435/00124635-200507000-00003.

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Latini, Eleonora, EnricoRoberto Curci, Andrea Massimiani, SvevaMaria Nusca, Flavia Santoboni, Donatella Trischitta, Mario Vetrano, and MariaChiara Vulpiani. "Ultrasonography for oxygen-ozone therapy in musculoskeletal diseases." Medical Gas Research 9, no. 1 (2019): 0. http://dx.doi.org/10.4103/2045-9912.254638.

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Strebkova, E. A. Strebkova, and L. I. Alekseeva Alekseeva. "Modern aspects of the use of local hyaluronic acid in musculoskeletal diseases." Therapy 2_2023 (April 17, 2023): 134–41. http://dx.doi.org/10.18565/therapy.2023.2.134-141.

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Davletiyarova, K. V., V. L. Soltanova, L. V. Kapilevich, and V. I. Andreyev. "Correction of disordered equilibrium function in students through exercise therapy." Bulletin of Siberian Medicine 8, no. 3 (June 28, 2009): 23–26. http://dx.doi.org/10.20538/1682-0363-2009-3-23-26.

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The method of stabilography was used to study the equilibrium function in students with vascular heart diseases and diseases of musculoskeletal system going in for exercise therapy (ET). The organization of physical training with the use exercise therapy favors the normalization of the equilibrium function and coordination abilities, and the effect is more pronounced in the group of students with diseases of the musculoskeletal system.

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Karateev, Karateev A. E., Lila A. M. Lila, and Alekseeva L. I. Alekseeva. "Management of patients with diseases of the musculoskeletal system during the COVID-19 pandemic." Therapy 1_2021 (February 19, 2021): 68–77. http://dx.doi.org/10.18565/therapy.2021.1.68-77.

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Dissertations / Theses on the topic "Musculoskeletal Diseases, therapy"

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Löfgren, Monika. "Multiprofessional rehabilitation for women with fibromyalgia : quantitative and qualitative studies /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-669-7/.

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Kammerlind, Ann-Sofi. "Vestibular rehabilitation therapy in dizziness and disequilibrium /." Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med914s.pdf.

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Rangan, Apoorva. "CRISPR-Cas9 Mediated Restoration of Dystrophin Expression and Inhibition of Myostatin: A Novel Gene Therapy for Duchenne Muscular Dystrophy." Scholarship @ Claremont, 2016. http://scholarship.claremont.edu/cmc_theses/1305.

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Duchenne Muscular Dystrophy (DMD) is an X-linked recessive genetic disease, caused by a frame-shift mutation in the dystrophin gene. Current gene therapies for DMD target dystrophin transcripts in existing skeletal and cardiac muscle, rather than adipose and fibrotic tissues. These approaches may be unable to repair muscle functionality in DMD patients who have already undergone extensive muscle damage and wasting. Thus, successful DMD therapies must consider the underlying genetic cause and pathology. Inhibition of the gene myostatin, a negative regulator of muscle growth, has been shown to ameliorate muscle loss. Here, the CRISPR-Cas9 gene-editing platform is proposed to restore dystrophin expression and inhibit myostatin as a novel gene therapy in DMD patient derived induced pluripotent stem cells. Successful CRISPR-Cas9 mediated gene editing would be determined using PCR amplification, western blot analysis, immunofluorescence staining, and off target sequence analysis in differentiated skeletal muscle cells.

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Smith, Brennan L. "MUSCLE SYNERGY DURING A SINGLE LEG STANDING TEST IN AMBULATORY CHILDREN WITH CEREBRAL PALSY." UKnowledge, 2018. https://uknowledge.uky.edu/khp_etds/51.

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INTRODUCTION: Cerebral Palsy (CP) is a sensorimotor disorder characterized by dysfunctional motor coordination, balance problems, and loss of selective motor control. Motor coordination exhibited as co-contraction, has been subjectively quantified using gait analysis, but recent studies have begun to objectively analyze the amount of co-contraction by collecting electromyography (EMG) data. Center of pressure excursion (COPE) measurements collected during a single leg standing test (SLST) have shown to be more valid measurements of balance in populations with motor disabilities than a SLST alone. A recent study has correlated increased COPE velocity with a lower fall risk as determined by reported fall frequency, suggesting a more objective measure of fall risk. The current study aimed to determine if the fall risk calculated by COPE velocity in children with CP is correlated with co-contraction index value in various muscle synergy groups. It was hypothesized that i) co-contraction index values will differ between high and low fall risk groups, ii) there will be preferential activation of different synergy groups within the high and low fall risk groups, and iii) there will be a negative and direct correlation between COPE velocity and co-contraction index values for all synergy groups. METHODS: Fall risk grouping was determined by average COPE velocity values calculated from previously reported fall frequency groups. Balance ability was determined by COPE measurements during a SLST on a force plate. Muscle synergy groups were determined by common muscle pairings at the hip, knee and ankle. Co-contraction indices were determined from linear envelopes plotted from muscle group EMG data. An independent t-test was run on muscle synergy groups between high and low fall risk groups. Nonparametric Analysis of Variance (ANOVA) and Tukey post-hoc tests were run on the high and low fall risk groups separately to determine differences in co-contraction index value within high and low fall risk groups. A Pearson correlation analyzed COPE velocity and co-contraction index value. RESULTS: No significant differences in muscle synergy between the high and low fall risk groups were found (p = 0.476, 0.076, 0.064, 0.364). The ANOVA and Tukey post-hoc tests for high fall risk group found significant differences in co-activation index value between the sagittal hip and frontal hip groups (p = 0.022) and sagittal hip and ankle groups (p = 0.016). Low fall risk group was found to have significant differences between the sagittal hip and frontal hip groups (p = 0.038) and frontal hip and knee groups (p = 0.012). Weak and negative correlations were found between COPE velocity and both knee and ankle groups (r = -0.309, -0.323, p = 0.059, 0.050). Negligible and insignificant correlations were found between frontal hip and sagittal hip synergies and COPE velocity ((r = 0.013, -0.068, p = 0.475, 0.367). CONCLUSION: There is insufficient evidence to claim that muscle group activations are different depending on fall risk grouped by COPE velocity. It is not currently possible to correlate COPE velocity to a specific synergy group recruitment. However, data do suggest that sagittal hip and knee strategies are recruited more than ankle and frontal hip strategies during SLST.

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Mayer, Kirby. "CHANGES IN MUSCLE SIZE, QUALITY AND POWER ARE RELATED TO PHYSICAL FUNCTION IN PATIENTS WITH CRITICAL ILLNESS." UKnowledge, 2019. https://uknowledge.uky.edu/rehabsci_etds/56.

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Patients admitted to intensive care unit (ICU) are known to develop significant impairments in physical function. Patients with critical illness suffer up to 30% reductions in muscle size within the first ten days of admission to the ICU. Muscle strength testing, Medical Research Council-sum score, is current gold-standard to diagnosis ICU-acquired weakness and predicts risk of mortality and long-term physical function. Muscle power different from muscle strength in that it accounts for velocity of movement, is potentially a better independent predictor of function that has not been studied in this population. In addition, we hypothesize that muscle size and quality measured through ultrasound imaging has better applicability and prediction that strength testing. Therefore, we prospectively collected data surrounding these muscle parameters in patients admitted to the medicine ICU at University of Kentucky. Primary outcomes included physical function, muscle power with a novel assessment tool for the critically ill population, muscle strength, and muscle size and quality assess through ultrasound imaging. 36 patients admitted to ICU and 18 aged-matched controlled were enrolled. Patients had significantly lower scores on muscle power assessment at ICU discharge (33.6 ±19.0 W; t= 4.01, p < 0.001) and at hospital discharge (40.9 ±16.5 W; t= 4.81, p < 0.001) in comparison to controls (59.3± 14.7 W). Patients with better scores on muscle power assessment had significantly better scores on physical function measures (Six-minute walk test; rs = 0.548, p = 0.0001). Muscle size (cross-sectional area of rectus femoris muscle) and muscle power were strongly correlated (rs = 0.66, p < 0.0001). These data suggest that patients with critical illness have significantly reduced muscle power which directly related to deficits in physical function.

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Kennedy, Zachary C. "Optimizing CRISPR/Cas9 for Gene Silencing of SOD1 in Mouse Models of ALS." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1047.

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Mutations in the SOD1 gene are the best characterized genetic cause of amyotrophic lateral sclerosis (ALS) and account for ~20% of inherited cases and 1-3% of sporadic cases. The gene-editing tool Cas9 can silence mutant genes that cause disease, but effective delivery of CRISPR-Cas9 to the central nervous system (CNS) remains challenging. Here, I developed strategies using canonical Streptococcus pyogenes Cas9 to silence SOD1. In the first strategy, I demonstrate effectiveness of systemic delivery of guide RNA targeting SOD1 to the CNS in a transgenic mouse model expressing human mutant SOD1 and Cas9. Silencing was observed in both the brain and the spinal cord. In the second strategy, I demonstrate the effectiveness of delivering both guide RNA and Cas9 via two AAVs into the ventricles of the brain of SOD1G93A mice. Silencing was observed in the brain and in motor neurons within the spinal cord. For both strategies, treated mice had prolonged survival when compared to controls. Treated mice also had improvements in grip strength and rotarod function. For ICV treated mice, we detected a benefit of SOD1 silencing using net axonal transport assays, a novel method to detect motor neuron function in mice before onset of motor symptoms. These studies demonstrate that Cas9-mediated genome editing can mediate disease gene silencing in motor neurons and warrants further development for use as a therapeutic intervention for SOD1-linked ALS patients.

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Dale, James Edward. "Tailoring therapy to individual patient's needs : intensive management of early rheumatoid arthritis using either clinical, laboratory or musculoskeletal ultrasound assessment of disease activity." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/4991/.

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Background: Outcomes in the management of early rheumatoid arthritis (RA) have been significantly improved through the use of composite disease activity measures (such as the DAS28) and aggressive DMARD escalation until a lower disease activity target has been achieved. Imaging studies suggest that the DAS28 may be insensitive to low levels of subclinical active disease that is associated with an increased risk of flare and progressive joint damage. Further, in some cases, elevations of the DAS28 may not necessarily be related to on going active synovitis. In both instances, relying upon the DAS28 assessment alone may lead to patients being considered for an inappropriate treatment decision since, patients with active subclinical disease may not be considered for further DMARD escalation whilst patients with non-inflammatory causes of DAS28 elevation may be offered additional DMARD therapy that is either ineffective or potentially toxic. There is emerging evidence that musculoskeletal ultrasound (MSUS), gene expression profiles and inflammatory protein microarrays might provide useful additional disease activity information that allows clinicians to reach a treatment decision that is targeted at an individual patient’s specific needs Objectives: 1. To determine whether using MSUS assessment of global disease activity in addition to the DAS28 produces significantly better short-medium term clinical and radiological outcomes 2. To determine whether grouping early RA patients by either RA phenotype or disease activity level is associated with evidence of differential gene expression between the comparator groups 3. To determine the degree of correlation and agreement between the Multi-Biomarker Disease Activity (MBDA) test, the DAS28 and a MSUS disease activity assessment Methods 111 patients with either clinical diagnoses of early RA (symptom duration < 1 year) or anti-CCP antibody positive inflammatory arthritis were recruited to the Targeting Synovitis in Early Rheumatoid Arthritis (TaSER) study. Clinical consultations occurred monthly for 18 months and all participants were treated using the same step-up DMARD-biologic escalation protocol. Participants were randomised to either a DAS28 or MSUS assessment group. In the DAS28 group, DMARD therapy was escalated until DAS28 low disease activity (LDAS – DAS28 <3.2) had been achieved. In the MSUS group, MSUS assessment was indicated for instances of DAS28 LDAS or DAS28 moderate disease activity (3.2≤ DAS28 <5.1) with minimal clinical synovitis (28SJC ≤1). During MSUS assessment, the bilateral radiocarpal, index and middle MCP, index and middle PIP and 2nd and 5th MTP joints were examined for the presence of gray scale synovial hypertrophy and Power Doppler (PD) signal. Active disease was defined as the presence of grade 1 or higher PD signal in 2 or more joints. DMARD therapy was not changed if there had been significant escalation within the preceding 3 months. Intra-articular and intra-muscular corticosteroid injections were administered generously during periods of active disease. Blinded clinical outcomes were collected at baseline and every 3 months until study completion. Plain x-rays of hands and feet and MRI of the dominant wrist and hand were performed at baseline and study completion and will be graded by 2 independent radiologists who are blinded to participant’s randomisation group. Primary outcomes comprised: 1. mean change in DAS44 from baseline and 18 months, 2. mean change in MRI RAMRIS erosion score between baseline and 18 months. Secondary outcome measures included: between group comparisons of the DAS44 and ACR-EULAR remission rates, EULAR response criteria, HAQ, EURO-QoL 5D, CRP, ESR, 10cm pain visual analogue score, mean change in plain x-ray Sharp score (van der Heijde modification) and mean change in MRI RAMRIS synovitis and bone marrow oedema scores. 79 Participants donated additional blood samples for nested biomarker analysis at baseline, follow-up months 3 and 18. Baseline and 3 month PAXgene RNA samples were analysed with the assistance of the Systems Biology Group, Institute of Cardiovascular and Medical Sciences, University of Glasgow using an Illumina HumanHT-12v4 Beadchip microarray. Baseline, 3 month and 18 month serum samples were analysed by Crescendo Biosciences using their in house MBDA microarray. Additional whole blood, serum and plasma samples remain available for future polyomic analyses. For the gene expression analysis, participants were segregated into comparator groups based upon baseline and 3 month RA phenotypic and disease activity data. Comparator groups were intended to represent common clinical scenarios. Between group comparisons of gene expression were conducted in the R software package using the Linear Models for Microarray Data (Limma) plug-in. An adjusted p value <0.05 was considered to represent evidence of differential gene expression. For the MBDA analysis, the degree of correlation (Spearman’s rank correlation) between DAS28 and MBDA score was calculated at each time point and for all time points pooled together. The percentage agreement between MBDA, DAS28 and MSUS disease activity state categorisations was also calculated. Results 111 participants were recruited and 101 (91%) completed follow-up. 95 (86%) participants fulfilled 1987 ACR RA classification criteria and 107 (96%) fulfilled 2010 ACR-EULAR RA classification criteria. The presenting features appeared typical of an early RA cohort and, excepting gender, there were no statistical differences in baseline characteristics between the groups 414 MSUS assessments were performed, 369 MSUS assessments coincided with DAS28 LDAS, of which 92 (25%) identified active synovitis. 271 MSUS assessments coincided with DAS28 remission, of which 66 (24%) identified active synovitis. 45 MSUS assessments coincided with DAS28 moderate disease activity of which 15 (33%) identified active synovitis. Overall 71% of paired DAS28 and MSUS assessments agreed on the disease activity state MSUS-driven DMARD escalation was not associated with significant improvements in clinical outcomes. Both groups experienced a similar mean change in DAS44 between baseline and 18 months (DAS28 -2.51 vs MSUS -2.76, p 0.39). There were no statistically significant between group differences in the ACR core set variables at any of the time points, nor their mean change from baseline. Over the follow-up period, the MSUS assessment group demonstrated incremental increases in the proportion of participants with EULAR good responses and DAS44 remission and a significantly higher rate of DAS44 remission at study completion (DAS28 44% vs MSUS 65%, p=0.045). The impact of MSUS-driven DMARD escalation on radiological outcomes, medium-long term outcomes and adverse event rates remains to be determined. At baseline, gender (61 genes), RhF status (5 genes) and current smoking (1 gene) were associated with evidence of differential gene expression. The expression patterns of 19 genes changed following commencement of DMARD monotherapy. However, it was not possible to demonstrate evidence of differential gene expression in relation to disease activity level or phenotypic extremes at either time point. Up-regulation of 3 genes at baseline was associated with requiring DMARD escalation at 3 months. Otherwise, baseline gene expression was not predictive of 3 month disease activity state nor disease course over 12 months. Mean baseline interferon response gene score was not predictive of response to step-up DMARD therapy The MBDA test score correlated positively with DAS28 at a single time point (rs=0.58, p<0.0001) and the change correlated positively with corresponding changes in DAS28 (rs=0.56, p<0.0001).

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Batistão, Mariana Vieira. "Postura na infância prevalência de variações posturais e fatores associados avaliação de um programa de exercícios randomizado controlado." Universidade Federal de São Carlos, 2013. https://repositorio.ufscar.br/handle/ufscar/5306.

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Postural variations are common in childhood / adolescence and are corrected spontaneously. When maintained can cause overload. The objective of the first study was to evaluate the prevalence of postural variations in children / adolescents and to identify factors that explain these variations among age, gender, manual preference, body mass index (BMI) and physical activity, through multiple logistic regression analysis. 288 students were evaluated through postural observation. They were 59.4% female, mean age 10.6 (2.4) years, body mass 38.6 (12.7) kg and height 1.5 (0.1) m. Results show high prevalence of postural changes and their association with factors: age (forward head posture, shoulders and iliac crests asymmetry winged scapula), sex (winged scapula), BMI (forward head, iliac crest asymmetry, valgus knees and winged scapula) and not perform physical activity (valgus knees). Among the factors evaluated, obesity is a modifiable factor. Therefore, its association with the changes must be explored to facilitate the planning of preventive measures and more effective treatment. So, the objectives of the second study were to describe the prevalence of overweight in adolescents and identify differences in posture, (evaluated qualitatively and quantitatively) and the reporting of musculoskeletal pain (assessed by an adaptation of the Nordic Questionnaire) among normal weight and overweight in a large sample of students. 420 students were evaluated, 60% female, with mean age 11.1 (2.3) years, height 1.5 (0.1) m. body mass 44.5 (14.1) kg. Findings indicate that the prevalence of overweight was 36.2%. There was a higher prevalence of thoracic kyphosis, lumbar hyperlordosis and valgus knees with overweight students. There was no association between the presence of pain and weight excess. In childhood and adolescence, the posture lies in the development process. Therefore, any functional change to poor posture will reflect negatively in the future. So, the objective of the third study was to evaluate the effects of an exercise program of stretching and strengthening exercises in relation to posture, mobility of the spine and musculoskeletal pain in primary school children. Qualitative and quantitative postural evaluation of the trunk, pain and spine mobility (Whistance method) were collected before and after the intervention. The subjects were randomly assigned to groups. The exercise program was applied in groups, at school, twice weekly for eight weeks, for 50 minutes. The analysis included 78 subjects in the intervention group and 93 in the control, with mean age 11.6 (1.7) years, 1.5 (0.1) meters of height, 46.3 (14.1) kg of mass. It was also comprised of 67.3% female. The control group showed greater worsening percentage than intervention group to the posture of the shoulders. For the pain, the intervention group showed greater improvement percentage. These results show that the exercise program as described is effective in pain and posture of the shoulders. For other variables, adjustments in the duration of the program and individualized care may be recommended.
Variações posturais são frequentes na infância/adolescência e são corrigidas espontaneamente. Quando mantidas podem causar sobrecarga. O objetivo do primeiro estudo foi avaliar a prevalência de variações posturais em crianças/adolescentes e identificar fatores explicativos para estas variações, dentre: idade, sexo, dominância manual, índice de massa corporal (IMC) e atividade física, por meio da análise de regressão logística múltipla. Foram avaliados por meio de observação postural 288 escolares, sendo 59,4% do sexo feminino; idade média de 10,6 (2,4) anos, massa corporal 38,6 (12,7) kg e altura 1,5 (0,1) metros. Os resultados mostram altas prevalências de alterações posturais e sua associação com os fatores avaliados: idade (anteriorização da cabeça, assimetria entre os ombros e cristas ilíacas e escápulas aladas), sexo (escápulas aladas), IMC (anteriorização da cabeça, elevação da crista, joelhos valgos e escápulas aladas) e não realização de atividade física (joelhos valgos). Dentre os fatores avaliados, a obesidade é um fator modificável. Portanto, sua associação com as alterações deve ser explorada para propiciar o planejamento de medidas preventivas e de tratamento mais eficazes. Nesse sentido, os objetivos do segundo estudo foram: descrever a prevalência de excesso de peso em escolares, e identificar diferenças na postura, avaliada de forma qualitativa e quantitativa, e no relato de dor musculoesquelética (avaliada por uma adaptação do Questionário Nórdico) entre sujeitos eutróficos e com excesso de peso em uma ampla amostra de escolares. Foram avaliados 420 escolares, sendo 60% do sexo feminino, com médias de idade 11,1(2,3) anos; altura 1,5(0,1) metros e massa corporal 44,5(14,1) kg. A prevalência de excesso de peso foi 36,2%. Houve maior prevalência de hipercifose torácica, hiperlordose lombar e joelhos valgos entre os estudantes com excesso de peso. Não houve associação entre a presença de dor e o excesso de peso. Como na infância e adolescência a postura encontra-se em processo de desenvolvimento, qualquer alteração funcional conseguinte à má postura irá repercutir negativamente no futuro. Portanto, o objetivo do terceiro estudo foi avaliar os efeitos de um programa de exercícios de alongamento e fortalecimento muscular em relação à postura do tronco, mobilidade da coluna vertebral e dor musculoesquelética em estudantes do ensino fundamental. Avaliação postural qualitativa e quantitativa (SAPo), dor e mobilidade da coluna (método de Whistance) foram coletados antes e após a intervenção. Os sujeitos foram aleatoriamente alocados nos grupos. O programa de exercícios foi aplicado em grupo, no ambiente escolar, duas vezes por semana por oito semanas, durante 50 minutos. A análise contou com 78 sujeitos no grupo intervenção e 93 no controle, com médias de idade 11,6(1,7) anos, 1,5(0,1) metros de altura, 46,3(14,1) quilogramas de massa. Era também constituída de 67,3% do sexo feminino. O grupo controle apresentou porcentagem de piora maior que o grupo intervenção para a postura dos ombros. Para a presença de dor, o grupo intervenção apresentou maior porcentagem de melhora. Esses resultados mostram que o programa de exercícios como descrito tem efeito na a dor e na postura dos ombros. Para as outras variáveis, ajustes na duração do programa e atendimento individualizado podem ser recomendados.

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Griesmeyer, Carol K. "Osteoarthritis of the knee and acupuncture use in pain control." 2004. http://www.ocomlibrary.org/images/PDF/studentpapers/carolgriesmeyer.pdf.

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Perriman, Diana Margaret. "The dynamic measurement and conservative treatment of thoracic hyperkyphosis." Phd thesis, 2011. http://hdl.handle.net/1885/150257.

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Age-related hyperkyphosis of the thoracic spine is a problem which potentially affects all adults. It can result in movement dysfunction and may lead to mechanical failure of the thoracic spine, especially in the presence of osteoporosis, due to overwhelming forces exerted by gravity and muscular contraction. A number of studies have endeavoured to evaluate exercise-based programmes aimed at reducing hyperkyphosis in older adults. However, the multimodal nature of these programmes may reflect the uncertainty about which strategies are most effective. Stroke is a condition which affects 322 000 people in Australia at any given time. Rehabilitation strategies for stroke have commonly excluded resisted strengthening strategies because of fears of increasing spasticity. However, recent studies have failed to confirm this concern. Loss of back extensor strength (BES) is a feature of stroke which is detrimental to function. The effect of resisted BES exercise on function in people with stroke has not been examined. This thesis describes a number of studies that each inform the design and execution of a randomised controlled trial (RCT) which aimed to establish the relative effectiveness of BES exercises and postural re-education ireducing hyperkyphosis. The preliminary studies included three experiments validating the flexible electrogoniometer (FEG) as a tool to measure thoracic kyphosis, a survey looking at the normal practice of Australian physiotherapists with respect to thoracic hyperkyphosis; three experiments using surface electromyography (sEMG), kinematic and force measurements to determine whether sitting or prone lying was a better exercise positions for strengthening the thoracic erector spinae (TES); an ultrasound study looking at the anatomy of two sEMG recording sites; and a study validating the myometry used in the RCT. The three FEG validation studies included: a bench test for accuracy, a test-retest reliability study and a study of concurrent validity comparing FEG angle to corresponding Cobb angles. The studies indicated that the FEG is a reliable instrument with excellent day-to-day reliability (ICC{u2082},{u2081} = 0.92; p < 0.0001 ). When compared with the Cobb angle for concurrent validity, the FEG was found to have the best agreement with the Cobb angle for the section of spine between mid end-blocks (r = 0.814 - 0.821, p = 0.001) with an absolute difference of 3.5{u00B0}{u00B1} 6.9{u00B0}. A stratified cross-sectional mailed survey was used to examine how Australian physiotherapists from varying practice groups assess and manage hyperkyphosis. It revealed that postural re-education, stretching and strengthening were the interventions most frequently used to treat thoracic kyphosis but that the measurement tools used to evaluate treatment effectiveness were primarily subjective. A prospective observational study which used real time ultrasound to image the muscles overlying the erector spinae at T3 and L4 established that the thoracic erector spinae (TES) could not be accurately recorded with sEMG. Therefore, a comparative analysis of the relative contributions of the TES and lumbar erector spinae (LES) was achieved by comparing the forces developed during prone and seated extension and the levels of LES activation. The results indicated that the TES were recruited to a greater extent during seated extension with scapular retraction than they were during prone extension. In addition, a kinematic study comparing the two exercises showed that prone extension primarily resulted in hyperextension of the lumbar spine with limited thoracic extension. A test-retest study of a seated myometry method for testing BES showed that it had excellent day-to day reliability (ICC{u2082},{u2081} = 0.96 (95% CI 0.83 - 0.99)). The minimum difference needed to detect a real difference in force generated between measurements (MD) was 20.7N for extension with retraction. The RCT was subject blinded and utilised a 2X2 factorial design to compare the effects of postural re-education and strengthening. Both stroke and non-stroke (normal) subjects were included although the majority of the subjects were normal. The results of the RCT indicated that, overall, the strengthening intervention resulted in better outcomes in terms of physical ability but that there was no significant reduction in kyphotic angle. The results also suggest that the angular changes which did occur mainly occurred in the upper thoracic spine. Thoracic spine movement frequency was found to be very low in both the sagittal (0.001Hz) and coronal (0.002 Hz) planes which may have implications for the nutrition of the intervertebral disc. There were no differences between the stroke and non-stroke cohorts in terms of their responses to the intervention. The main clinical significance of this work is the discovery that an increase in back extensor strength does not necessarily result in a clinically significant decrease in thoracic kyphosis, especially at the apex of the curve. Further research is required to explore the best conditions in terms of load and position for thoracic extension strengthening for decreasing kyphosis. The effect of intervention on movement frequency is potentially an area of significant interest with respect to reducing the rate of disc disease.

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Books on the topic "Musculoskeletal Diseases, therapy"

1

Lewit, Karel. Manipulative therapy: Musculoskeletal medicine. Edinburgh: Elsevier/Churchill Livingstone, 2009.

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Lewit, Karel. Manipulative therapy: Musculoskeletal medicine. Edinburgh: Elsevier/Churchill Livingstone, 2009.

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Lewit, Karel. Manipulative therapy: Musculoskeletal medicine. Edinburgh: Churchill Livingstone/Elsevier, 2010.

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Edwardson, Barbara M. Musculoskeletal disorders: Common problems. San Diego, Calif: Singular Pub. Group, 1994.

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Davies, Richard. Musculoskeletal problems. Oxford: Oxford University Press, 2006.

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Prentice, William E. Techniques in Musculoskeletal Rehabilitation. New York: McGraw-Hill, 2007.

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K, Freedman Mitchell, Morrison William B, and Harwood Marc I, eds. Minimally invasive musculoskeletal pain medicine. New York: Informa Healthcare, 2007.

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K, Freedman Mitchell, Morrison William B, and Harwood Marc I, eds. Minimally invasive musculoskeletal pain medicine. New York: Informa Healthcare, 2007.

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Annette, Iglarsh Z., ed. Musculoskeletal approach to maxillofacial pain. Philadelphia: Lippincott, 1991.

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Hertling, Darlene. Management of common musculoskeletal disorders: Physical therapy principles and methods. 2nd ed. Philadelphia: Lippincott, 1990.

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Book chapters on the topic "Musculoskeletal Diseases, therapy"

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Adler, Joseph. "Musculoskeletal/Orthopedic Diseases and Disorders." In Acute Care Physical Therapy, 311–50. 2nd ed. New York: Routledge, 2024. http://dx.doi.org/10.4324/9781003522485-8.

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Kuwert, Torsten. "Radionuclide Imaging and Therapy of Inflammatory Joint Lesions." In Musculoskeletal Diseases 2009–2012, 194–97. Milano: Springer Milan, 2009. http://dx.doi.org/10.1007/978-88-470-1378-0_31.

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Erba, Paola Anna, Martina Sollini, Roberta Zanca, Roberto Boni, Lesley Flynt, Elena Lazzeri, Giuliano Mariani, and Torsten Kuwert. "Hybrid Imaging and Radionuclide Therapy of Musculoskeletal Diseases." In Nuclear Medicine Textbook, 571–644. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-95564-3_24.

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Pers, Yves-Marie, Dominique Farge, and Christian Jorgensen. "Musculoskeletal Stromal/Progenitor Cell-Based Cell Therapy for Rheumatoid Arthritis (RA)." In Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases, 138–46. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781315151366-17.

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Linetsky, Felix S., Hakan Alfredson, David Crane, and Christopher J. Centeno. "Treatment of Chronic Painful Musculoskeletal Injuries and Diseases with Regenerative Injection Therapy (RIT): Regenerative Injection Therapy Principles and Practice." In Treatment of Chronic Pain by Integrative Approaches, 145–68. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1821-8_12.

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Linetsky, Felix S., Hakan Alfredson, David Crane, and Christopher J. Centeno. "Treatment of Chronic Painful Musculoskeletal Injuries and Diseases with Regenerative Injection Therapy (RIT): Regenerative Injection Therapy Principles and Practice." In Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches, 889–912. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-1560-2_81.

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Hosoi, Masayuki, Yosuke Yakushiji, and Shiro Tanaka. "Clinical Application of Exercise Therapy in Diabetes." In Musculoskeletal Disease Associated with Diabetes Mellitus, 269–77. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55720-3_18.

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Fletcher, Barry D., and Soheil L. Hanna. "Muscle Edema Associated with Musculoskeletal Neoplasms and Radiation Therapy." In Muscle Imaging in Health and Disease, 413–23. New York, NY: Springer New York, 1996. http://dx.doi.org/10.1007/978-1-4612-2314-6_32.

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Yokoyama, Hisayo. "Clinical Application of Exercise Therapy in Diabetes with Chronic Kidney Disease." In Musculoskeletal Disease Associated with Diabetes Mellitus, 279–96. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55720-3_19.

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Carotti, Marina, Emilio Filippucci, Fausto Salaffi, and Fabio Martino. "Therapy Efficacy Evaluation in Synovitis." In Musculoskeletal Ultrasound in Orthopedic and Rheumatic disease in Adults, 233–48. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-91202-4_26.

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Conference papers on the topic "Musculoskeletal Diseases, therapy"

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Mosentseva, E. A. "THE APPLICATION OF PRP THERAPY FOR THE TREATMENT OF DISEASES OF THE MUSCULOUS-MOTOR EQUIPMENT IN HORSES." In DIGEST OF ARTICLES ALL-RUSSIAN (NATIONAL) SCIENTIFIC AND PRACTICAL CONFERENCE "CURRENT ISSUES OF VETERINARY MEDICINE: EDUCATION, SCIENCE, PRACTICE", DEDICATED TO THE 190TH ANNIVERSARY FROM THE BIRTH OF A.P. Stepanova. Publishing house of RGAU - MSHA, 2021. http://dx.doi.org/10.26897/978-5-9675-1853-9-2021-48.

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A review of the PRP-therapy technology for the treatment of pathologies of the musculoskeletal system in horses is made. A number of clinical and laboratory studies have been analyzed and the main advantages and disadvantages of this therapy have been identified.

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Putri, Kurnia Eka, Bhisma Murti, and Hanung Prasetya. "The Effectiveness of Acupuncture in Reducing Musculoskeletal Pain: A Meta-Analysis." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.52.

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ABSTRACT Background: Musculoskeletal disorder affects the musculoskeletal system’s function, which includes tendons, bursae, bones, muscles, joints, and ligaments. Acupuncture is one of the non-pharmacological alternative therapies for treating musculoskeletal disorders. This study aimed to examine the effectiveness of acupuncture in reducing pain in musculoskeletal diseases. Subjects and Method: This was a meta-analysis and systematic review. The study was collected articles from PubMed, ProQuest, Science Direct, Scopus, Spinger Link, and Google Scholar databases. The inclusion criteria were full text in English language and used randomized controlled trial study design. There were 8 articles with 466 study subjects comprised in two groups, including 236 people received acupuncture therapy (intervention) and 230 people received sham acupuncture (control). The selected articles were analyzed by ReVman 5.4. Results: This study had high heterogeneity (I2= 90%; p<0.001). This study reported that acupuncture was more effective to reduce musculoskeletal pain than sham acupuncture (Mean Difference= 1.63; 95% CI= 0.89 to 2.38; p= 0.001). Conclusion: Acupuncture is more effective to reduce musculoskeletal pain than sham acupuncture. Keywords: acupuncture, musculoskeletal pain Correspondence: Kurnia Eka Putri. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: nia.putrinia@gmail.com. Mobile: +628995212646. DOI: https://doi.org/10.26911/the7thicph.05.52

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Shreder, K., A. Cucu, D. Kraft, S. Lehrian, J. Kondol, G. Klein, B. Frey, U. Gaipl, and C. Fournier. "P114 Ionising radiation inhibits inflammation in patients with musculoskeletal diseases: radon treatment vs low-dose radiation therapy." In 38th European Workshop for Rheumatology Research, 22–24 February 2018, Geneva, Switzerland. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-ewrr2018.129.

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Domingos, Francine de Paula Roberto, Sayuri Aparecida Hirayama, Rafael de Almeida, Lucas Silva Dias, Paulo Henrique Martinelli Oliveira, Raderi Luiz Cardoso dos Santos, Larissa Miyashiro, Lorena Dias de Araújo, and Gustavo Carvalho Costa. "Atypical presentation of Stiff Person syndrome: case report." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.490.

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Introduction: Stiff Person syndrome (SPS) is a rare, immune-mediated neurological disease related to several antibodies, the most obvious being Antiglutamic acid decarboxilase (GAD). This case intends to show atypical clinical presentation of Stiff Person Syndrome, in which the patient started with ataxia and gait alteration, evolving with dimidiated spasms. Case report: L.S.M, male, 58 years old, denied previous comorbidities, smoking and alcoholism. He woke up with vertigo, associated with dysarthria and ataxia in the left side of the body. Two weeks after the onset of symptoms, he evolved with gait alteration and began to have episodes of painful, intermittent muscle spasms in the left upper and lower limbs. He presented negative serology for human immunodeficiency virus, syphilis and viral hepatitis, in addition to nonreagent rheumatological markers. Magnetic resonance imaging revealed a focus of signal alteration affecting the corticosubcortical surface of the cingulate gyrus on the right side, possibly corresponding to an inflammatory/demyelinating process. Cerebrospinal fluid analysis showed the presence of oligoclonal bands and anti-GAD reagent, with non-reactive anti-aquaporin 4. Discussion: The typical symptomatology of SPS involves the musculoskeletal component, representing up to close to 93% of the symptoms referred by the patients. Among other predominant symptoms, pain (82%) and bulbar dysfunction (47%) stand out. Some patients may have atypical symptoms, especially during the onset of symptoms. The case exposes the predominance of vertigo and ataxic symptoms, unusual for this stage of SPS, which may lead to difficulties in the investigation. Conclusion: Recognizing the atypical patterns of clinical presentation is an important responsibility of the neurologist, since early diagnostic elucidation is essential for defining the patient’s prognostic determination therapy.

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Reports on the topic "Musculoskeletal Diseases, therapy"

1

Chou, Roger, Jesse Wagner, Azrah Y. Ahmed, Ian Blazina, Erika Brodt, David I. Buckley, Tamara P. Cheney, et al. Treatments for Acute Pain: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), December 2020. http://dx.doi.org/10.23970/ahrqepccer240.

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Objectives. To evaluate the effectiveness and comparative effectiveness of opioid, nonopioid pharmacologic, and nonpharmacologic therapy in patients with specific types of acute pain, including effects on pain, function, quality of life, adverse events, and long-term use of opioids. Data sources. Electronic databases (Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews) to August 2020, reference lists, and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) of outpatient therapies for eight acute pain conditions: low back pain, neck pain, other musculoskeletal pain, neuropathic pain, postoperative pain following discharge, dental pain (surgical or nonsurgical), pain due to kidney stones, and pain due to sickle cell disease. Meta-analyses were conducted on pharmacologic therapy for dental pain and kidney stone pain, and likelihood of repeat or rescue medication use and adverse events. The magnitude of effects was classified as small, moderate, or large using previously defined criteria, and strength of evidence was assessed. Results. One hundred eighty-three RCTs on the comparative effectiveness of therapies for acute pain were included. Opioid therapy was probably less effective than nonsteroidal anti-inflammatory drugs (NSAIDs) for surgical dental pain and kidney stones, and might be similarly effective as NSAIDs for low back pain. Opioids and NSAIDs were more effective than acetaminophen for surgical dental pain, but opioids were less effective than acetaminophen for kidney stone pain. For postoperative pain, opioids were associated with increased likelihood of repeat or rescue analgesic use, but effects on pain intensity were inconsistent. Being prescribed an opioid for acute low back pain or postoperative pain was associated with increased likelihood of use of opioids at long-term followup versus not being prescribed, based on observational studies. Heat therapy was probably effective for acute low back pain, spinal manipulation might be effective for acute back pain with radiculopathy, acupressure might be effective for acute musculoskeletal pain, an opioid might be effective for acute neuropathic pain, massage might be effective for some types of postoperative pain, and a cervical collar or exercise might be effective for acute neck pain with radiculopathy. Most studies had methodological limitations. Effect sizes were primarily small to moderate for pain, the most commonly evaluated outcome. Opioids were associated with increased risk of short-term adverse events versus NSAIDs or acetaminophen, including any adverse event, nausea, dizziness, and somnolence. Serious adverse events were uncommon for all interventions, but studies were not designed to assess risk of overdose, opioid use disorder, or long-term harms. Evidence on how benefits or harms varied in subgroups was lacking. Conclusions. Opioid therapy was associated with decreased or similar effectiveness as an NSAID for some acute pain conditions, but with increased risk of short-term adverse events. Evidence on nonpharmacological therapies was limited, but heat therapy, spinal manipulation, massage, acupuncture, acupressure, a cervical collar, and exercise were effective for specific acute pain conditions. Research is needed to determine the comparative effectiveness of therapies for sickle cell pain, acute neuropathic pain, neck pain, and management of postoperative pain following discharge; effects of therapies for acute pain on non-pain outcomes; effects of therapies on long-term outcomes, including long-term opioid use; and how benefits and harms of therapies vary in subgroups.

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