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Journal articles on the topic 'Musculoskeletal Diseases, therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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1

Kozlova, Kozlova I. V., Kudishina M. M. Kudishina, Bykova A. P. Bykova, and Krylova Yu S. Krylova. "Pathology of the musculoskeletal system in inflammatory bowel diseases." Therapy 7_2021 (October 15, 2021): 50–57. http://dx.doi.org/10.18565/therapy.2021.7.50-57.

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2

Talbot, K. "Musculoskeletal diseases: from complex genetics to therapy." Current Opinion in Pharmacology 3, no. 3 (June 2003): 277–79. http://dx.doi.org/10.1016/s1471-4892(03)00044-4.

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3

Karateev, Andrei Evgenyevich. "Combination therapy for pain in musculoskeletal diseases." Neurology, neuropsychiatry, Psychosomatics, no. 4 (December 15, 2012): 76. http://dx.doi.org/10.14412/2074-2711-2012-427.

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4

Belluzzi, Elisa, Assunta Pozzuoli, and Pietro Ruggieri. "Musculoskeletal Diseases: From Molecular Basis to Therapy." Biomedicines 12, no. 1 (December 22, 2023): 32. http://dx.doi.org/10.3390/biomedicines12010032.

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5

Huang, Wan, and Gwendolyn Sowa. "Biomarker Development for Musculoskeletal Diseases." PM&R 3 (June 2011): S39—S44. http://dx.doi.org/10.1016/j.pmrj.2011.04.023.

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6

Evans, Christopher H., Steven C. Ghivizzani, James H. Herndon, and Paul D. Robbins. "Gene Therapy for the Treatment of Musculoskeletal Diseases." Journal of the American Academy of Orthopaedic Surgeons 13, no. 4 (July 2005): 230–42. http://dx.doi.org/10.5435/00124635-200507000-00003.

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7

Latini, Eleonora, EnricoRoberto Curci, Andrea Massimiani, SvevaMaria Nusca, Flavia Santoboni, Donatella Trischitta, Mario Vetrano, and MariaChiara Vulpiani. "Ultrasonography for oxygen-ozone therapy in musculoskeletal diseases." Medical Gas Research 9, no. 1 (2019): 0. http://dx.doi.org/10.4103/2045-9912.254638.

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8

Strebkova, E. A. Strebkova, and L. I. Alekseeva Alekseeva. "Modern aspects of the use of local hyaluronic acid in musculoskeletal diseases." Therapy 2_2023 (April 17, 2023): 134–41. http://dx.doi.org/10.18565/therapy.2023.2.134-141.

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Davletiyarova, K. V., V. L. Soltanova, L. V. Kapilevich, and V. I. Andreyev. "Correction of disordered equilibrium function in students through exercise therapy." Bulletin of Siberian Medicine 8, no. 3 (June 28, 2009): 23–26. http://dx.doi.org/10.20538/1682-0363-2009-3-23-26.

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The method of stabilography was used to study the equilibrium function in students with vascular heart diseases and diseases of musculoskeletal system going in for exercise therapy (ET). The organization of physical training with the use exercise therapy favors the normalization of the equilibrium function and coordination abilities, and the effect is more pronounced in the group of students with diseases of the musculoskeletal system.

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Karateev, Karateev A. E., Lila A. M. Lila, and Alekseeva L. I. Alekseeva. "Management of patients with diseases of the musculoskeletal system during the COVID-19 pandemic." Therapy 1_2021 (February 19, 2021): 68–77. http://dx.doi.org/10.18565/therapy.2021.1.68-77.

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11

Kuo, Tom K., Jennifer H. Ho, and Oscar K. Lee. "Mesenchymal Stem Cell Therapy for Nonmusculoskeletal Diseases: Emerging Applications." Cell Transplantation 18, no. 9 (September 2009): 1013–28. http://dx.doi.org/10.3727/096368909x471206.

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Mesenchymal stem cells are stem/progenitor cells originated from the mesoderm and can different into multiple cell types of the musculoskeletal system. The vast differentiation potential and the relative ease for culture expansion have established mesenchymal stem cells as the building blocks in cell therapy and tissue engineering applications for a variety of musculoskeletal diseases, including repair of fractures and bone defects, cartilage regeneration, treatment of osteonecrosis of the femoral head, and correction of genetic diseases such as osteogenesis imperfect. However, research in the past decade has revealed differentiation potentials of mesenchymal stem cells beyond lineages of the mesoderm, suggesting broader applications than originally perceived. In this article, we review the recent developments in mesenchymal stem cell research with respect to their emerging properties and applications in nonmusculoskeletal diseases.

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12

Banik, Amitav, Md Ruhul Amin, Md Harun Or Rashid, Himadri Shekhor Saha, and Anisur Rahman. "Disease Pattern of Musculoskeletal Disorders of the Patients Attending Outdoor of the Department of Physical Medicine and Rehabilitation, Sir Salimullah Medical College, Dhaka." Sir Salimullah Medical College Journal 30, no. 2 (October 20, 2022): 186–89. http://dx.doi.org/10.3329/ssmcj.v30i2.61937.

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Background: Physical medicine and rehabilitation (PM&R) is a medical speciality focused on prevention, diagnosis, rehabilitation, and therapy for patients who experience functional limitations resulting from injury, disease, or malformation. Department of Physical Medicine and Rehabilitation (PMR) at Sir Salimullah Medical College and Mitford Hospital provides outdoor services for different musculoskeletal and neurological disorders which include counseling, drug management, physical therapy, speech therapy, ADL training etc. In this study, we enrolled only the patients of musculoskeletal disorders. Objectives: To understand the disease pattern and demographic characteristics of the patients of Musculoskeletal disorders presenting to the department of PMR. This will increase the awareness regarding PMR services among doctors and other health care providers and also to facilitate rehabilitation plan of a musculoskeletal disorder. Methods: This cross-sectional observational study was done on outdoor patients attending the Department of PMR at Sir Salimullah Medical College from 1st January, 2021 to 31st December, 2021. We have enrolled only the patients of musculoskeletal disorders. Results: Total number of patients was 13644, most of them were female. Maximum number of patients belong to 20-50 years of range and they mainly come from surrounding urban areas. Regarding the musculoskeletal disease pattern, 34.2% patients presented with mechanical low back pain (LBP) and related diseases, 11.4% patients with neck pain, 13.7% with knee pain, 9.4% with shoulder pain, soft tissue rheumatism (STR) comprises of 8.7%, 4.6% with heel pain and related disorders, 14.3% with rheumatological diseases, other musculoskeletal diseases contribute to 3.7%. Patients with LBP and related diseases were diagnosed as non-specific mechanical LBP (74%), Herniated disc disease(5%), Lumbar spondylosis, Spondylolisthesis (2%), etc. Conclusion: LBP and related diseases affect most of the people attending outdoor with musculoskeletal diseases. Sir Salimullah Med Coll J 2022; 30: 186-189

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13

Vaca-González, Juan Jairo, Juliana I. P. Cantillo Bermúdez, Liliana Andrea Rodríguez Sarmiento, and Aldemar Fonseca Velásquez. "Electromagnetic fields as a non-invasive alternative therapy for the treatment of musculoskeletal diseases." Journal of Applied Research and Technology 20, no. 3 (July 1, 2022): 245–59. http://dx.doi.org/10.22201/icat.24486736e.2022.20.3.1790.

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This review article elucidates the application and viability of electromagnetic fields as therapy and rehabilitation method for the treatment of musculoskeletal pathologies. All studies were found in different databases such as Science Direct, Scielo, IEEE, ProQuest, Pubmed, among others, where the search for information contemplated a period of 5 years (2016-2020). Results evidenced that electromagnetic fields used to treat musculoskeletal conditions showed positive results and improvements in reducing chronic and acute pain in different musculoskeletal pathologies such as osteoarthritis, osteoporosis, nonunions, fractures, fibromyalgia, muscular system injuries, among others. It was possible to evidence that one of the most used magnetic treatments were pulsed electromagnetic fields, which have been implemented to treat joint, muscle and nervous diseases. Additionally, several devices to generate the magnetic stimulation have been designed with a therapeutic and rehabilitation approach, which elucidate the progress in the implementation and acceptance of this type of therapeutic alternatives to treat musculoskeletal conditions. Finally, magnetic stimulation has been also implemented to enhance biomaterials function, evidencing that scaffolds stimulated with electromagnetic fields improve musculoskeletal tissue regeneration.

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14

Imametdinova, G. R., and E. V. Igolkina. "Topical diclofenac for the treatment of the musculoskeletal diseases." Medical Council, no. 12 (July 29, 2018): 98–104. http://dx.doi.org/10.21518/2079-701x-2018-12-98-104.

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Treatment of diseases of the musculoskeletal system to date remains not only a serious medical, but also socio-economic problem. Chronic diseases of the joints and spine are one of the most common causes of disability in patients. The main clinical manifestations of most diseases of the musculoskeletal system are pain and inflammation, which requires adequate antiinflammatory therapy. The data on various mechanisms of action of non-steroidal anti-inflammatory drug (NSAID) diclofenac (Voltaren), as well as the results of clinical studies and meta-analyses confirming its effectiveness and good tolerability are presented. The data of experimental and clinical studies of the efficacy and safety of local forms of diclofenac-Voltaren Emulgel (diclofenac-diethylamine) –are presented. Provides information about the form of the Voltaren Emulgel 2% for 12 hours. It is shown that a wide range of analgesic and anti-inflammatory effects of diclofenac (Voltaren), and good tolerance can be used as symptomatic therapy in the treatment of diseases of the musculoskeletal system.

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15

Multari, Lori A. "Book Review: Principles of physical medicine in the musculoskeletal diseases." Canadian Journal of Occupational Therapy 58, no. 3 (August 1991): 144–45. http://dx.doi.org/10.1177/000841749105800311.

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16

Davletiyarova, K. V., L. V. Kapilevich, V. L. Soltanova, Ye B. Baranova, and V. I. Andreyev. "Adaptation possibilities of students going to exercise therapy." Bulletin of Siberian Medicine 10, no. 3 (June 28, 2011): 116–19. http://dx.doi.org/10.20538/1682-0363-2011-3-116-119.

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The cardiointervalography method was used to study adaptation possibilities of students with vascular heart diseases and diseases of musculoskeletal system going to exercise therapy. The physical training organization with use exercise therapy favors the adaptation and functional reserve improvement, and the effect is more in 1st year study students with vascular heart diseases.

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17

Voloshyn, O. I., O. V. Glubochenko, I. V. Pankiv, V. G. Glubochenko, and I. V. Prysiazhniuk. "Rheumatic manifestations of thyroid pathology. Literature review." Clinical Endocrinology and Endocrine Surgery, no. 1 (April 6, 2022): 57–67. http://dx.doi.org/10.30978/cees-2022-1-57.

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Thyroid disease can be accompanied by a variety of rheumatic manifestations, ranging from early growth defects during infancy to adult manifestations such as arthralgias, myalgias, myopathy, acropachy, arthritis, osteoporosis. Objective — to provide a summarizing current literature on the analysis of a variety of musculoskeletal disorders in hyperthyroidism and hypothyroidism and possible mechanisms that explain this connection. Materials and methods. The authors conducted a systematic literature search for relevant Englishlanguage publications published between June 2011 and October 2021 in MedLine, PubMed, and Google Scholar. A variety of rheumatic manifestations in hyperthyroidism and hypothyroidism include: arthropathy, myopathy, adhesive shoulder capsulitis, thyroid acropachy, tunnel (carpal) syndrome, Raynaud’s phenomenon, Hoffman’s syndrome, osteoporosis. Thyroid diseases commonly cause musculoskeletal complaints and may even present with rheumatic syndromes before the nature of the underlying endocrinopathy is apparent. On occasion, thyroid disorders can mimic some rheumatic diseases and leading to diagnostic errors. On the other hand, thyroid disorders can coexist with rheumatic diseases as well as rheumatic symptoms and findings. Musculoskeletal complaints can be related to unidentified and untreated thyroid diseases. However, it is important to keep in mind that the therapy for these diseases might lead to myopathies. As a result, internists, endocrinologists, and rheumatologists should be well-versed in recognizing how thyroid illnesses influence the musculoskeletal system and must be aware of these correlations to ensure that the associated condition is not missed, or the diagnosis is not delayed. This will aid in avoiding diagnostic mistakes and provide early suspicion of thyroid pathology and correct treatment. Keywords: rheumatic manifestations, hyperthyroidism, hypothyroidism, thyroid pathology, musculoskeletal syndrome.

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18

Begidova, Tamara P., and Ekaterina Y. Mukina. "PNF-therapy in complex rehabilitation of individuals with musculoskeletal system disorders." Tambov University Review. Series: Humanities, no. 1 (2022): 165–71. http://dx.doi.org/10.20310/1810-0201-2022-27-1-165-171.

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The subject of the study is the assessment of the integrated application of rehabilitation measures with the use of PNF-therapy in disorders of the musculoskeletal system. The analysis of the available scientific and methodological literature revealed insufficient study and practical implementation of modern rehabilitation techniques for musculoskeletal system disorders of various etiologies, showing the increasing relevance of physical rehabilitation in the modern world. Rehabilitation for chronic diseases of the musculoskeletal system is a continuous process that requires constant adaptation of the methods used to the needs of the person with disabilities. Studies of the effect of PNF-therapy should include: sensorimotor control of limbs, sitting and standing, control of movement coordination, regularity of exercise and health-related quality of life. The data obtained can be used in the practice of teaching students, undergraduates, graduate students and attendees of faculties and retraining and advanced training courses in the field of “Physical education for individuals with disabilities (adaptive physical education)”, as well as instructors in adaptive physical education in the rehabilitation of people with diseases of the musculoskeletal system. Theoretical aspects related to the use of PNF-therapy in the complex rehabilitation of persons with musculoskeletal system lesions are discovered. Forecast of the probable direction of perspective physical rehabilitation development for this contingent is given.

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19

Shen, Wei, Yong Li, and Johnny Huard. "Musculoskeletal Gene Therapy and its Potential Use in the Treatment of Complicated Musculoskeletal Infection." Infectious Disease Clinics of North America 19, no. 4 (December 2005): 1007–22. http://dx.doi.org/10.1016/j.idc.2005.07.005.

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20

Allameh, Farzad, Atefeh Javadi, Sahar Dadkhahfar, Zahra Naeeji, Atefeh Moridi, Niki Tadayon, and Sam Alahyari. "A Systematic Review of Elective Laser Therapy during Pregnancy." Journal of Lasers in Medical Sciences 12, no. 1 (September 19, 2021): e50-e50. http://dx.doi.org/10.34172/jlms.2021.50.

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Introduction: Currently, lasers are used to treat many diseases and their complications. However, the use of lasers in pregnant patients is still controversial. Methods: In this review, the application of lasers in the fields of urology, surgery, obstetrics, dermatology, and musculoskeletal disorders is evaluated. The following keywords were used to search through PubMed, Google Scholar, and Scopus: pregnancy, laser, urolithiasis, endovenous laser ablation (EVLA) or treatment, leg edema, varicose vein, venous insufficiencies, hair removal, pigmentation, telangiectasia, vascular lesions, Q switch laser, diode laser, holmium, holmium-YAG laser, erbium laser and Pulsed dye laser, low-level laser therapy, high-intensity laser therapy, pain, musculoskeletal disorders, twin to twin transfusion syndrome (TTTS), amnioreduction, and safety. Results: Totally, 147 articles were found, and their abstracts were evaluated; out of 53 articles extracted, 14 articles were about dermatology, 24 articles were about urology, 12 articles were about obstetrics and gynecology, 10 articles were about musculoskeletal disorders and three articles were related to surgery. Conclusion: Laser therapy can be used as a safe treatment for urolithiasis, skin diseases, TTTS and varicose veins of the lower extremities. However, the use of laser therapy for musculoskeletal disorders during pregnancy is not recommended due to lack of evidence, and also we cannot recommend endovenous ablation.

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21

Isaikina, M. A., A. I. Isaikin, and L. T. Akhmedzhanova. "Efficacy and safety of aceclofenac in musculoskeletal diseases." Neurology, Neuropsychiatry, Psychosomatics 15, no. 2 (April 30, 2023): 114–19. http://dx.doi.org/10.14412/2074-2711-2023-2-114-119.

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Musculoskeletal system pathology is one of the main causes of morbidity and disability worldwide. Inflammation plays the leading role in the genesis of these diseases. Pain is the most important factor leading to a critical decrease in the quality of life and limitation of daily activities. Most current international guidelines for the treatment of acute and chronic low back and neck pain, osteoarthritis, rheumatoid arthritis and other diseases recommend oral non-steroidal anti-inflammatory drugs as first-line therapy. The article presents data from the latest domestic and international studies, including the results of the largest SOS study, which demonstrated the high efficacy and safety of aceclofenac (Aertal) in acute and chronic neck and back pain.

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22

Klimov, L. V. "Musculoskeletal pain: diagnostic issues and treatment." Clinical pharmacology and therapy 35, no. 4 (November 3, 2022): 61–64. http://dx.doi.org/10.32756/0869-5490-2022-4-61-64.

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Musculoskeletal pain is one of the main manifestations of joint and spine diseases. Chronic pain poses an enormous burden for patients, society and health care system. Patient with musculoskeletal pain requires multimodal therapy. Risk factors for chronic pain should be identified using biopsycho social model. Review article presents approaches to treatment of musculoskeletal pain.

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23

Karateev, A. E. "Chronic musculoskeletal pain: pathogenesis, clinical features, therapy possibilities." Clinical Medicine (Russian Journal) 100, no. 11-12 (January 17, 2023): 527–34. http://dx.doi.org/10.30629/0023-2149-2022-100-11-12-527-534.

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The control of musculoskeletal pain (MSP) is an important part of the complex treatment of rheumatic diseases (RD). Analgesic therapy still plays the leading role in osteoarthritis (OA) and chronic nonspeciﬁc back pain (most cases of this syndrome are associated with spinal OA) treatment. Despite the use of modern basic anti-inﬂammatory drugs (including biological and JAK inhibitors), the problem of MSP control remains relevant in immuno-inﬂammatory diseases, such as rheumatoid arthritis and spondyloarthritis. The pathogenesis of MSP is complex and closely related to the processes of damage, inﬂammation and degeneration. A fundamental role here belongs to local and systemic inﬂammatory response occurrence, which largely determines such elements of the pathogenesis of chronic MSP as peripheral and central sensitization. Depending on the prevailing pathogenesis mechanisms, MSP can manifest itself in several phenotypes: «inﬂammatory», «mechanical», «enthesopathic», associated with central sensitization. A combination with such symptoms as stiﬀness, fatigue, muscle tension, sleep disturbance, depression and anxiety is characteristic for MSP. The control should be comprehensive and must include the use of both drug and drug-free preparations. Nonsteroidal anti-inﬂammatory drugs, opioids, muscle relaxants, antidepressants and anticonvulsants, local injection therapy (glucocorticoids, hyaluronic acid, platelet-rich plasma), as well as methods of physiotherapy and rehabilitation are used in pain treatment.

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24

Takács, Roland, Patrik Kovács, Rana Abdelsattar Ebeid, János Almássy, János Fodor, László Ducza, Richard Barrett-Jolley, Rebecca Lewis, and Csaba Matta. "Ca2+-Activated K+ Channels in Progenitor Cells of Musculoskeletal Tissues: A Narrative Review." International Journal of Molecular Sciences 24, no. 7 (April 5, 2023): 6796. http://dx.doi.org/10.3390/ijms24076796.

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Musculoskeletal disorders represent one of the main causes of disability worldwide, and their prevalence is predicted to increase in the coming decades. Stem cell therapy may be a promising option for the treatment of some of the musculoskeletal diseases. Although significant progress has been made in musculoskeletal stem cell research, osteoarthritis, the most-common musculoskeletal disorder, still lacks curative treatment. To fine-tune stem-cell-based therapy, it is necessary to focus on the underlying biological mechanisms. Ion channels and the bioelectric signals they generate control the proliferation, differentiation, and migration of musculoskeletal progenitor cells. Calcium- and voltage-activated potassium (KCa) channels are key players in cell physiology in cells of the musculoskeletal system. This review article focused on the big conductance (BK) KCa channels. The regulatory function of BK channels requires interactions with diverse sets of proteins that have different functions in tissue-resident stem cells. In this narrative review article, we discuss the main ion channels of musculoskeletal stem cells, with a focus on calcium-dependent potassium channels, especially on the large conductance BK channel. We review their expression and function in progenitor cell proliferation, differentiation, and migration and highlight gaps in current knowledge on their involvement in musculoskeletal diseases.

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25

Kostine, Marie, Marie-Elise Truchetet, and Thierry Schaeverbeke. "Clinical characteristics of rheumatic syndromes associated with checkpoint inhibitors therapy." Rheumatology 58, Supplement_7 (December 1, 2019): vii68—vii74. http://dx.doi.org/10.1093/rheumatology/kez295.

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AbstractCompared with conventional cancer therapies, the spectrum of toxicities observed with checkpoint inhibitors is unique and can affect any organ system. Arthralgia and myalgia were by far the most commonly reported rheumatic immune-related adverse events in clinical trials, and there is now a growing number of case series and reports describing clinical features of de novo rheumatic immune-related adverse events, which will be the focus of this review. Some patients develop genuine classic rheumatic and musculoskeletal diseases, but a number of rheumatic immune-related adverse events mimic rheumatic and musculoskeletal diseases with atypical features, mainly polymyalgia rheumatica, rheumatoid arthritis and myositis, as well as several systemic conditions, including sicca syndrome, vasculitis, sarcoidosis, systemic sclerosis and lupus.

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26

Feng, Site, Jiahao Li, Jingjing Tian, Sheng Lu, and Yu Zhao. "Application of Single-Cell and Spatial Omics in Musculoskeletal Disorder Research." International Journal of Molecular Sciences 24, no. 3 (January 23, 2023): 2271. http://dx.doi.org/10.3390/ijms24032271.

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Musculoskeletal disorders, including fractures, scoliosis, heterotopic ossification, osteoporosis, osteoarthritis, disc degeneration, and muscular injury, etc., can occur at any stage of human life. Understanding the occurrence and development mechanism of musculoskeletal disorders, as well as the changes in tissues and cells during therapy, might help us find targeted treatment methods. Single-cell techniques provide excellent tools for studying alterations at the cellular level of disorders. However, the application of these techniques in research on musculoskeletal disorders is still limited. This review summarizes the current single-cell and spatial omics used in musculoskeletal disorders. Cell isolation, experimental methods, and feasible experimental designs for single-cell studies of musculoskeletal system diseases have been reviewed based on tissue characteristics. Then, the paper summarizes the latest findings of single-cell studies in musculoskeletal disorders from three aspects: bone and ossification, joint, and muscle and tendon disorders. Recent discoveries about the cell populations involved in these diseases are highlighted. Furthermore, the therapeutic responses of musculoskeletal disorders, especially single-cell changes after the treatments of implants, stem cell therapies, and drugs are described. Finally, the application potential and future development directions of single-cell and spatial omics in research on musculoskeletal diseases are discussed.

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27

Bashir, Jamil, Andrew Sherman, Henry Lee, Lee Kaplan, and Joshua M. Hare. "Mesenchymal Stem Cell Therapies in the Treatment of Musculoskeletal Diseases." PM&R 6, no. 1 (January 2014): 61–69. http://dx.doi.org/10.1016/j.pmrj.2013.05.007.

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28

Alcaraz, María José, Alvaro Compañ, and María Isabel Guillén. "Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases." Cells 9, no. 1 (December 31, 2019): 98. http://dx.doi.org/10.3390/cells9010098.

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Mesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal diseases. There is compelling evidence indicating that MSC effects are mainly mediated by paracrine mechanisms and in particular by the secretion of extracellular vesicles (EVs). Many studies have thus suggested that EVs may be an alternative to cell therapy with MSCs in tissue repair. In this review, we summarize the current understanding of MSC EVs actions in preclinical studies of (1) immune regulation and rheumatoid arthritis, (2) bone repair and bone diseases, (3) cartilage repair and osteoarthritis, (4) intervertebral disk degeneration and (5) skeletal muscle and tendon repair. We also discuss the mechanisms underlying these actions and the perspectives of MSC EVs-based strategies for future treatments of musculoskeletal disorders.

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Zhemchuzhkina, Tatyana, and Ivan Kurochkin. "SPECTRAL CHARACTERISTICS OF THE ELECTROMYOGRAPHIC SIGNAL TO ASSESS THE QUALITY OF THERAPY AND REHABILITATION IN PATIENTS WITH LOW BACK PAIN." Grail of Science, no. 29 (July 19, 2023): 322–31. http://dx.doi.org/10.36074/grail-of-science.07.07.2023.055.

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Disorders and diseases of the musculoskeletal system are the most important factor in the global need for rehabilitation services. Low back pain is the leading cause of the global burden of musculoskeletal disease. Objectification of the assessment of the state of the musculoskeletal system can help in diagnosing and differentiating the patient's conditions, assessing the quality of therapy and rehabilitation. This work is devoted to the analysis of quantitative criteria for assessing the state of the musculoskeletal system according to objective data of electromyographic research.

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Tavast, Esko, Tamara Tuuminen, Sari H. Pakkanen, Mari Eriksson, Anu Kantele, Asko Järvinen, Liana Pusa, et al. "Immunosuppression Adversely Affects TST but Not IGRAs in Patients with Psoriasis or Inflammatory Musculoskeletal Diseases." International Journal of Rheumatology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/381929.

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The performance of the interferon gamma release assays (IGRAs) and tuberculin skin test (TST) was reviewed retrospectively in patients with psoriasis, inflammatory musculoskeletal diseases, or miscellaneous inflammatory conditions. The study was carried out over a 22-month period using 109 records of patients with psoriasis (), musculoskeletal disease (), or other inflammatory conditions (). Forty-four (48%) of 109 patients were on immunosuppressive therapy and 38/109 (35%) on systemic glucocorticoid therapy. The agreement between the IGRAs was substantial () whilst that between the IGRAs and TST was low (). Logistic regression models revealed that IGRAs associated with risk factors for latent tuberculosis infection better than TST. TST was influenced by age, BCG vaccination, sex, and glucocorticoid therapy. We found that IGRAs performed equally well with low level of indeterminate results (1-2%). IGRAs were superior to TST because the latter was influenced by BCG-vaccination status and immunosuppressive therapy.

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Sugawara, A. T., M. D. C. Lima, C. B. Dias, and M. S. C. Oliveira. "Extracorporeal shockwave therapy for pain reduction of musculoskeletal diseases: Predictors and responders." Annals of Physical and Rehabilitation Medicine 61 (July 2018): e171. http://dx.doi.org/10.1016/j.rehab.2018.05.390.

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32

Balatska, Nataliya, Vladyslav Povoroznyuk, and Viktor Muts. "WCO06. Therapy of people with musculoskeletal system diseases and vitamin D deficiency." Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo 11 (June 2016): 11. http://dx.doi.org/10.1016/s1646-3439(16)30055-4.

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33

Carter, Stephanie K., and John A. Rizzo. "Use of Outpatient Physical Therapy Services by People With Musculoskeletal Conditions." Physical Therapy 87, no. 5 (May 1, 2007): 497–512. http://dx.doi.org/10.2522/ptj.20050218.

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Background and PurposeBecause musculoskeletal conditions contribute to functional decline and activity limitation, physical therapy intervention may be an appropriate health care resource. The purpose of this research was to identify determinants of outpatient physical therapy use by people with musculoskeletal conditions.SubjectsThe subjects were adult noninstitutionalized civilians who participated in the Medical Expenditure Panel Survey from 1996 to 2000 and who had at least one musculoskeletal condition (N=18,546).MethodsLogistic regression was used to identify predisposing, need, and enabling variables associated with receiving outpatient physical therapy services.ResultsFactors that were positively associated with receiving physical therapy services were having more than one musculoskeletal condition, having some limitation in function, having 7 or more ICD-9 (International Classification of Diseases, 9th Revision) codes, having a college or advanced degree, and residing in an urban area. Factors that were negatively associated with receiving physical therapy services were being older than 65 years of age, having no high school degree, Hispanic ethnicity, African-American race, having public insurance or no insurance, and living in any US census region besides the Northeast.Discussion and ConclusionThe results of this study indicate that health- and non–health-related factors influence outpatient physical therapy use.

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Onsea, Soentjens, Djebara, Merabishvili, Depypere, Spriet, De Munter, et al. "Bacteriophage Application for Difficult-to-treat Musculoskeletal Infections: Development of a Standardized Multidisciplinary Treatment Protocol." Viruses 11, no. 10 (September 23, 2019): 891. http://dx.doi.org/10.3390/v11100891.

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Bacteriophage therapy has recently attracted increased interest, particularly in difficult-to-treat infections. Although it is not a novel concept, standardized treatment guidelines are currently lacking. We present the first steps towards the establishment of a “multidisciplinary phage task force” (MPTF) and a standardized treatment pathway, based on our experience of four patients with severe musculoskeletal infections. After review of their medical history and current clinical status, a multidisciplinary team found four patients with musculoskeletal infections eligible for bacteriophage therapy within the scope of Article 37 of the Declaration of Helsinki. Treatment protocols were set up in collaboration with phage scientists and specialists. Based on the isolated pathogens, phage cocktails were selected and applied intraoperatively. A draining system allowed postoperative administration for a maximum of 10 days, 3 times per day. All patients received concomitant antibiotics and their clinical status was followed daily during phage therapy. No severe side-effects related to the phage application protocol were noted. After a single course of phage therapy with concomitant antibiotics, no recurrence of infection with the causative strains occurred, with follow-up periods ranging from 8 to 16 months. This study presents the successful outcome of bacteriophage therapy using a standardized treatment pathway for patients with severe musculoskeletal infection. A multidisciplinary team approach in the form of an MPTF is paramount in this process.

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Vallati, Carlo, Antonio Virdis, Marco Gesi, Nicola Carbonaro, and Alessandro Tognetti. "ePhysio: A Wearables-Enabled Platform for the Remote Management of Musculoskeletal Diseases." Sensors 19, no. 1 (December 20, 2018): 2. http://dx.doi.org/10.3390/s19010002.

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Technology advancements in wireless communication and embedded computing are fostering their evolution from standalone elements to smart objects seamlessly integrated in the broader context of the Internet of Things. In this context, wearable sensors represent the building block for new cyber-physical social systems, which aim at improving the well-being of people by monitoring and measuring their activities and provide an immediate feedback to the users. In this paper, we introduce ePhysio, a large-scale and flexible platform for sensor-assisted physiotherapy and remote management of musculoskeletal diseases. The system leverages networking and computing tools to provide real-time and ubiquitous monitoring of patients. We propose three use cases which differ in scale and context and are characterized by different human interactions: single-user therapy, indoor group therapy, and on-field therapy. For each use case, we identify the social interactions, e.g., between the patient and the physician and between different users and the performance requirements in terms of monitoring frequency, communication, and computation. We then propose three related deployments, highlighting the technologies that can be applied in a real system. Finally, we describe a proof-of-concept implementation, which demonstrates the feasibility of the proposed solution.

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Tomaszewski, Wiesław, and Katarzyna Malinowska. "Neuropathy – Damage to Peripheral Nerves in Diseases and Injuries of the Musculoskeletal System." Ortopedia Traumatologia Rehabilitacja 19, no. 6 (December 30, 2017): 569–76. http://dx.doi.org/10.5604/01.3001.0010.8073.

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The musculoskeletal diseases and injuries affect not only the musculoskeletal system itself, but also the closely related structures, such as blood vessels and nerves (both within the central and the peripheral nervous system). If these relationships are neglected or the directed neuroprotective and neuro-regeneration therapy is delayed, the final effect of the treatment is compromised. The aim if this paper is describing the important medical and social problem of peripheral neuropathies from the point of view of epidemiology, etiopathogenesis, imaging diagnostics and complex medical procedures using modern approaches and techniques, based on the available literature.

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Korotkiy, Valeriy, Elena Perets, Vladimir Pasko, and Bogdan Korotkiy. "Mechanical and resonance manipulation in the treatment of diseases of the musculoskeletal system." Manual Therapy 2022, no. 2 (July 20, 2022): 15–21. http://dx.doi.org/10.54504/1684-6753-2022-2-15-21.

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The article describes a method of manual manipulation where the necessary movement of the element of the musculoskeletal system, which was selected for exposure, is performed in accordance with the principles of achieving vibrational and translational mechanical resonance. This method of mechanical and resonance manipulation proved to be more effective and less traumatic in clinical practice when compared with the traditional manipulation method, and the intended effect, which consisted in increasing mobility and more physiologically correct arrangement of the exposed elements of the musculoskeletal system, was more pronounced, namely, greater mobility was achieved with a more uniform increase in the mobility of all the exposed elements of the musculoskeletal system. At the same time, fewer manual therapy sessions by 30% were required for achieving the planned therapeutic effect, and, due to less trauma to biological tissues during mechanical and resonance manipulation, the sessions were less painful.

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Maduakonam, Dim Edwin, Lam Ying Lee, Ho Wai Yip Kenneth, Yau Ching Hin Raymond, and WH Shek Tony. "Tuberculous osteomyelitis of the proximal femur masquerading as bone secondary: A case report." Journal of Orthopaedics, Trauma and Rehabilitation 27, no. 1 (March 24, 2020): 72–76. http://dx.doi.org/10.1177/2210491720907492.

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Tuberculosis is a mycobacterial infection, but it can mimic many diseases including diseases of the musculoskeletal system. The need to consider it as a differential diagnosis of musculoskeletal tumours and tumour-like conditions cannot be overemphasized. The opinions of some, that tuberculosis is a disease of the undeveloped world, can no longer be sustained especially in the presence of immunodeficiency disorders, including HIV/AIDS, which have a worldwide prevalence. Traditionally, literature evidence shows that tuberculosis can mimic quite a number of diseases, including cancers. This has been found to be true, even in some technologically advanced countries. We present a case of hepatocellular cancer patient incidentally found to have concomitant hepatic tuberculosis who complained of bone lesion, with clinico-radiologic features of metastasis, but which turned out to be a tuberculous infection of the bone.

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Sanchez, Adalberto Loyola, Ingris Pelaez-Ballestas, and Ana Gabriela Cruz-Martín. "Community-Based Rehabilitation for Mayan People with Musculoskeletal Diseases: a QUAN/QUAL Evaluation." Archives of Physical Medicine and Rehabilitation 100, no. 10 (October 2019): e54-e55. http://dx.doi.org/10.1016/j.apmr.2019.08.150.

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Sajan, Abin, Sandeep Bagla, and Ari Isaacson. "Musculoskeletal Interventions: A Review on Genicular Artery Embolization." Seminars in Interventional Radiology 38, no. 05 (November 24, 2021): 511–14. http://dx.doi.org/10.1055/s-0041-1736529.

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AbstractSymptomatic knee pain is one of the most common joint diseases that affects millions of people worldwide. The treatment for knee pain secondary to osteoarthritis (OA) begins with conservative therapy and progresses to surgical intervention when conservative therapy fails. Genicular artery embolization (GAE) offers an alternative option for patients who are poor surgical candidates. Multiple studies have been conducted worldwide demonstrating the safety and efficacy of GAE in patients with mild to moderate OA. The purpose of this article is to describe the current literature on GAE and highlight the latest findings from a randomized controlled trial comparing GAE versus sham embolization.

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Abreu, Hugo, Elena Canciani, Davide Raineri, Giuseppe Cappellano, Lia Rimondini, and Annalisa Chiocchetti. "Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future." Cells 11, no. 1 (December 24, 2021): 43. http://dx.doi.org/10.3390/cells11010043.

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Tissue regeneration is a hot topic in health sciences, particularly because effective therapies promoting the healing of several cell types are lacking, specifically those of the musculoskeletal system. Mesenchymal Stem/Stromal Cells (MSCs) have been identified as crucial players in bone homeostasis, and are considered a promising therapy for diseases such as osteoarthritis (OA) and Rheumatoid Arthritis (RA). However, some known drawbacks limit their use, particularly ethical issues and immunological rejections. Thus, MSCs byproducts, namely Extracellular Vesicles (EVs), are emerging as potential solutions to overcome some of the issues of the original cells. EVs can be modulated by either cellular preconditioning or vesicle engineering, and thus represent a plastic tool to be implemented in regenerative medicine. Further, the use of biomaterials is important to improve EV delivery and indirectly to modulate their content and secretion. This review aims to connect the dots among MSCs, EVs, and biomaterials, in the context of musculoskeletal diseases.

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Paula, Daniela Annanias Gimenes de, Ronaldo Alves da Cunha, and Carlos Vicente Andreoli. "HEALTH PROBLEMS OF BASKETBALL REFEREES:A PROSPECTIVE STUDY." Revista Brasileira de Medicina do Esporte 27, no. 2 (June 2021): 195–200. http://dx.doi.org/10.1590/1517-8692202127022021_0128.

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ABSTRACT Introduction: Basketball referees are the authorities responsible for ensuring that rules and regulations are followed and for making decisions. The ability of referees to respond to the physical and physiological demands imposed during the game is essential for good performance on the court. Objective: To understand the context in which health problems faced by basketball referees occur and to outline the epidemiological profile of musculoskeletal injuries. Methods: A prospective cohort study was conducted in which basketball referees were evaluated using a standardized form. The participants were monitored online weekly for 12 weeks using the Oslo Sports Trauma Research Center questionnaire to assess health problems, such as diseases (affecting the respiratory, cardiovascular, digestive or neurological systems) or musculoskeletal injuries (acute or from overuse). Results: The study sample consisted of 78 referees with a mean age of 36.5 (±9.8) years. Most referees (97.4%) found it important to implement a preventive program. In relation to the health problems reported during follow-up, there was an incidence rate of 23.7 injuries per 1000 hours of play (95% CI 19.5 - 27.9) and the mean weekly prevalence of diseases was 3.2 (95% CI 0.4 – 6.0) and of injuries was 17.4 (95% CI 16.5 – 18.3). Conclusion: Through this study, it was possible to conclude that there was an incidence rate of 23.7 injuries per 1000 hours of play (95% CI 19.5 - 27.9) and a mean prevalence of diseases of 3.2 (95% CI 0.4 - 6.0) and musculoskeletal injuries of 17.4 (95% CI 16.5 - 18.3). The most common health problems that affected basketball referees were musculoskeletal overuse injuries of the lower limbs. Level of evidence I; Prospective cohort study .

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Ostojic, Sergej M. "Should hydrogen therapy be included in a musculoskeletal medicine routine?" F1000Research 5 (November 10, 2016): 2659. http://dx.doi.org/10.12688/f1000research.9758.1.

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Molecular hydrogen (H2) has recently been recognized as a potential novel therapeutic agent in biomedicine. Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H2 improved clinical end-points and surrogate markers in several clinical trials, mainly acting as an anti-inflammatory agent and powerful antioxidant. In this paper, the medicinal properties of H2 in musculoskeletal medicine are discussed with the aim to provide an updated and practical overview for health professionals working in this field.

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Vertkin, A. L., A. N. Barinov, and G. Yu Knorring. "Changes in management of patients with diseases of musculoskeletal system and joints." Medical alphabet, no. 7 (June 6, 2021): 36–40. http://dx.doi.org/10.33667/2078-5631-2021-7-36-40.

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Pain syndrome accompanies the vast majority of diseases; therefore, the issues of adequate pain relief remain topical not only for urgent conditions, but also for everyday medical practice. Modern and changed in recent years approaches to the appointment of anesthetic therapy should take into account not only the pathogenetic mechanisms of the development of pain syndrome in a particular patient, but also the need to use drug combinations. This allows for the potentiation of the analgesic effect, reduction of effective dosages of individual drugs and minimization of side effects. In case of severe pain syndrome in the presence of signs of impaired nociception, neuropathic and muscle-fascial pain syndromes, the use of non-steroidal anti-inflammatory drugs in conjunction with group B vitamins is justified. The article considers the pathogenetic details of such a combination therapy, reveals the mechanisms of the cooperative action of the proposed combination of drugs.

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Kabra, Gayatri, Parvathy G. Nair, Pradeep Kumar P P, and Sudhakar D. "“KERALIYA VISHESHA CHIKITSA WITH SPECIAL REFRENCE TO KAYASEKA”." International Ayurvedic Medical Journal 9, no. 5 (May 15, 2021): 1071–75. http://dx.doi.org/10.46607/iamj2109052021.

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Kayaseka is speciality of keraliya Panchakarma which is modified form of Parisheka Sweda. It has both Snehana and Swedana effect. It yields good results in upper motor neuron lesion with spasticity and rigidity. It is indicated in traumatic conditions, musculoskeletal diseases and rejuvenation therapy. It has equivalent effect as that of Abhyantar Snehapana with appropriate selection of oil and proper techniques. Keyword: Keraliya Panchakarma, Kayaseka, Pizhi chil, Spasticity, Rigidity, Musculoskeletal disease.

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Denisov, L. N. "REASONABLE THERAPY OF PAIN SYNDROMES OF DISEASES OF T H E MUSCULOSKELETAL SYSTEM." Medical Council, no. 17 (January 1, 2017): 132–36. http://dx.doi.org/10.21518/2079-701x-2017-17-132-136.

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Bogdanov, E. I., T. G. Sakovets, and R. A. Altunbaev. "Efficiency of intra-articular, periarticular, local intramuscular and perineural injection therapy in the treatment of nociceptive and neuropathic pain syndromes." Kazan medical journal 96, no. 4 (August 15, 2015): 571–77. http://dx.doi.org/10.17750/kmj2015-571.

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Diseases of the musculoskeletal system are accompanied by nociceptive, neuropathic pain which is, in addition to kinesitherapy, physical therapy and acupuncture, widely treated using the local injection therapy. This treatment method is commonly used by physicians of different specialties for about 100 years and includes intra-articular, periarticular, perineural, intramuscular administration of different medicines, homeopathic remedies or medical devices. Hyaluronic acid salts, nonsteroid anti-inflammatory drugs, glucocorticosteroids, local anesthetics, vitamin B12, botulinum toxin A medications are often used for the treatment of degenerative conditions, posttraumatic joint disease, delayed complications of aseptic, bacterial and viral inflammatory, rheumatic processes within and out of the joints, such as: pathology of periarticular soft tissues as a consequence of local physical overload after acute injury, chronic microtrauma, sport trauma, affected facet joints and periarticular space at patients with dorsopathy, local muscle hypertonus (myofascial pain syndrome), neuropathy. The unique medication Hyalrepair-02/10 chondroreparant® based on the solid-state modificated hyaluronic acid salts and biogenic metabolites (non-drug bioorganic depot complex consisting of hyaluronic acid, amino acids and ascorbyl phosphates) is widely used at spine diseases and diseases of the musculoskeletal system, and it has showed good safety at local injection therapy. Heterogeneity of target tissues at patients with the musculoskeletal disorders, pharmacological substances as a part of injection drugs, and dosages of medicines and medical devices as well as individual patient reactions to the local therapy depending on severity of the disease, compensatory abilities and other reasons determines the necessity of carrying out a clinical comparison between different types of local injections with various groups of preparations.

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Lee, Nam-Woo, Gee-Heon Kim, In Heo, Koh-Woon Kim, In-Hyuk Ha, Jun-Hwan Lee, Eui-Hyoung Hwang, and Byung-Cheul Shin. "Chuna (or Tuina) Manual Therapy for Musculoskeletal Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–22. http://dx.doi.org/10.1155/2017/8218139.

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Objective. To review the literature and systematically evaluate the effectiveness of Chuna (or Tuina) manual therapy (C[T]MT) on pain and function for musculoskeletal disorders.Methods. We searched 15 English, Chinese, Japanese, and Korean databases using relevant keywords. All randomized controlled trials (RCTs) of C(T)MT for musculoskeletal disorders were considered, and we limited analyses to studies with a low-risk bias for randomization and/or allocation concealment.Results. Sixty-six RCTs with 6,170 participants were included. One sham-controlled RCT showed that C(T)MT relieved pain more effectively than a sham control (SMD-3.09[-3.59,-2.59]). For active-controlled RCTs, pooled meta-analysis showed that C(T)MT had statistically significant effects on pain reduction, especially compared to traction (P<0.00001), drugs (P=0.04), and physical therapies (P<0.0001). For functional improvement, combined effects of C(T)MT with drugs (P=0.04) and traction (P=0.05) also showed similar positive effects.Conclusions. This systematic review suggests that C(T)MT is safe and effective for pain reduction and functional improvement for musculoskeletal diseases; however, the evidence for functional improvement was not as strong as for pain reduction. For future studies, high-quality RCTs such as sham-controlled studies with standardized interventions are needed to provide sufficient evidence on the effects of C(T)MT for musculoskeletal diseases. Protocol registration number is CRD42016038307 04/07/2016.

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Rönnemaa, Tapani, and Auli Holstila. "Effectiveness of rehabilitation periods in patients with chronic musculoskeletal diseases of non-inflammatory origin." International Journal of Rehabilitation Research 11, no. 2 (June 1988): 193. http://dx.doi.org/10.1097/00004356-198806000-00020.

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Park, Gi-Young, and Dong Rak Kwon. "Application of Real-Time Sonoelastography in Musculoskeletal Diseases Related to Physical Medicine and Rehabilitation." American Journal of Physical Medicine & Rehabilitation 90, no. 11 (November 2011): 875–86. http://dx.doi.org/10.1097/phm.0b013e31821a6f8d.

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