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Relevant bibliographies by topics / Mutagenic synthesis

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Academic literature on the topic 'Mutagenic synthesis'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Mutagenic synthesis"

1

Tasleem, Faisal, Ayesha Bintay Farooq, Ijaz Ahmad, et al. "Assessment of Carcinogenic/Mutagenic Potential of Different Series of Synthetic Compounds." Haya: The Saudi Journal of Life Sciences 9, no. 07 (2024): 268–87. http://dx.doi.org/10.36348/sjls.2024.v09i07.005.

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The new drug research is usually based on synthesis medicine. The use of these medications has created problems such as tolerance in humans, for a long time and due to legitimate use of anti-infection, microbial defense against branded medication is growing. A mutagensis study by Ames in the early 1970's, used worldwide by drug and chemicals companies to diagnose mutagens carcinogenes, making it possible for them to be detected, and to be added to the mutagenic synthesis portion or radiation source triggering irreversible changes, and to the genetic material transmitted from the parent. deoxyr

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Kai, M. "Checkpoint activation regulates mutagenic translesion synthesis." Genes & Development 17, no. 1 (2003): 64–76. http://dx.doi.org/10.1101/gad.1043203.

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Jyotirmoy, Maity, Srivastava Smriti, Rana Rhea, Shankar Bhawani, Khanna Neena, and K. Prasad Ashok. "Biochemical synthesis of coumarin glycosides: A review." Journal of Indian Chemical Society Vol. 97, Feb 2020 (2020): 117–34. https://doi.org/10.5281/zenodo.5651400.

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Department of Chemistry, St. Stephen’s College, University of Delhi, Delhi-110 007, India Department of Chemistry, University of Delhi, Delhi-110 007, India Department of Chemistry, Shivaji College, University of Delhi, Delhi-110 027, India <em>E-mail:</em> ashokenzyme@gmail.com <em>Manuscript received online 11 October 2019, revised and accepted 14 December 2019</em> Coumarin glycosides have shown immense potential for diverse biological activities and have been explored extensively as highly prospective biomolecules. In recent years, coumarin glycosides have been used as enzyme inhibit

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Slameñová, Darina, Alena Gábelová, Katarina Ruppová, and Ladislave Wsólová. "Cytotoxic and Genotoxic Effects of Sodium Fluoride on Mammalian Cells at Neutral or Acid pH: A Summary of Published Work." Alternatives to Laboratory Animals 25, no. 3 (1997): 341–42. http://dx.doi.org/10.1177/026119299702500316.

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This paper forms a short review of some of our previously published work. We assessed the cytotoxic and genotoxic effects of sodium fluoride (NaF) on the Chinese hamster V79 cell line and the human EUE cell line at neutral and acid pH (as found in the stomach). The effects of NaF on cell proliferation, DNA synthesis, protein synthesis and mutagenesis were assessed. The results found showed no mutagenic effects after exposure to NaF, despite some cytogenic effects, suggesting that NaF probably does not represent any serious mutagenic or carcinogenic threat to humans.

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Kajimoto, Tetsuya, Manabu Node, Minoru Ozeki, Atsushi Muroyama, Tetsushi Watanabe, and Keiji Wakabayashi. "Synthesis of a New Mutagenic Benzoazepinoquinolinone Derivative." Synlett 2009, no. 11 (2009): 1781–84. http://dx.doi.org/10.1055/s-0029-1217358.

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Abdelnasser, Mohamed, Mark Hyland, and Neil D. Jespersen. "Synthesis of mutagenic compounds in crankcase oils." Environmental Science & Technology 20, no. 2 (1986): 145–49. http://dx.doi.org/10.1021/es00144a005.

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Saitkulova, F. G., I. I. Lapkin, T. S. Prokhorova, et al. "Synthesis, antimicrobial and mutagenic activity of ?-hydroxyketones." Pharmaceutical Chemistry Journal 19, no. 1 (1985): 41–43. http://dx.doi.org/10.1007/bf00767103.

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Nachtergael, Amandine, Déborah Lanterbecq, Martin Spanoghe, Alexandra Belayew, and Pierre Duez. "Effects of Chemopreventive Natural Compounds on the Accuracy of 8-oxo-7,8-dihydro-2′-deoxyguanosine Translesion Synthesis." Planta Medica 87, no. 10/11 (2021): 868–78. http://dx.doi.org/10.1055/a-1527-1435.

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AbstractTranslesion synthesis is a DNA damage tolerance mechanism that relies on a series of specialized DNA polymerases able to bypass a lesion on a DNA template strand during replication or post-repair synthesis. Specialized translesion synthesis DNA polymerases pursue replication by inserting a base opposite to this lesion, correctly or incorrectly depending on the lesion nature, involved DNA polymerase(s), sequence context, and still unknown factors. To measure the correct or mutagenic outcome of 8-oxo-7,8-dihydro-2′-deoxyguanosine bypass by translesion synthesis, a primer-extension assay

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Yudkina, Anna V., Anna A. Novikova, Anastasia D. Stolyarenko, Alena V. Makarova, and Dmitry O. Zharkov. "Bypass of Methoxyamine-Adducted Abasic Sites by Eukaryotic Translesion DNA Polymerases." International Journal of Molecular Sciences 26, no. 2 (2025): 642. https://doi.org/10.3390/ijms26020642.

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The apurinic/apyrimidinic site (AP site) is a highly mutagenic and cytotoxic DNA lesion. Normally, AP sites are removed from DNA by base excision repair (BER). Methoxyamine (MOX), a BER inhibitor currently under clinical trials as a tumor sensitizer, forms adducts with AP sites (AP-MOX) resistant to the key BER enzyme, AP endonuclease. As AP-MOX remains unrepaired, translesion DNA synthesis is expected to be the main mechanism of cellular response to this lesion. However, the mutagenic potential of AP-MOX is still unclear. Here, we compare the blocking and mutagenic properties of AP-MOX and th

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Choshi, Tominari, Akiko Tonari, Haruyuki Yoshioka, Kenichi Harada, Eiichi Sugino, and Satoshi Hibino. "Synthesis of mutagenic heterocyclic amines PhIP and DMIP." Journal of Organic Chemistry 58, no. 27 (1993): 7952–54. http://dx.doi.org/10.1021/jo00079a055.

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Dissertations / Theses on the topic "Mutagenic synthesis"

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Ratcliffe, Andrew J. "Synthesis of non-mutagenic anticancer drugs." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378598.

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Thomson, James B. "Synthesis and studies of oligonucleotides containing mutagenic 2'-deoxyguanosine derivatives." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/13125.

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The self-complementary dodecanucleotide d(CGC<i>O</i><SUP>6</SUP><i>MeG</i>AATT<i>T</i>GCG)<SUB>2</SUB> which contains two O<SUP>6</SUP>-methyl-2'-deoxyguanosine-thymine base pairs, has been analysed by X-ray diffraction methods and the structure refined to a residual error of R = 0.185 at 2.0<i>A</i> resolution. The O<SUP>6</SUP>MedG.T mispair closely resembles a Watson/Crick base pair and there are very few structural differences between the O<SUP>6</SUP>MedG.T duplex and the native analogue. The similarity between the O<SUP>6</SUP>MedG.T base pair and a normal dG.dC base pair explains the f

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Waters, Lauren S. (Lauren Stacey). "Novel regulatory mechanisms of mutagenic translesion DNA synthesis : characterization of REV1 in Saccharomyces cerevisiae." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38629.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2007.<br>Includes bibliographical references.<br>Cells are constantly subjected to DNA damage from endogenous and exogenous sources. Spontaneous DNA damage alone accounts for -30,000 DNA lesions per day in a mammalian cell. Cells are also exposed to an enormous variety of environmental agents that can cause a wide range of modified bases and aberrant DNA structures. To respond to the large diversity of DNA lesions that can be produced, cells possess a host of DNA repair and damage tolerance systems. The majority of these

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Schuisky, Peter. "Synthesis of metal complexes and potential food mutagens /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1998. http://epsilon.slu.se/avh/1998/91-576-5517-0.gif.

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Clergé, Adeline. "HAP oxydés : étude des effets génotoxiques in-vitro et caractérisation des adduits à l'ADN par spectrométrie de masse Oxy-PAHs: occurrence in the environment and potential genotoxic/mutagenic risk assessment for human health Evaluation of cytotoxicity and mutagenicity of 7 oxy-PAHs Synthesis, purification, and characterization of stable deoxyguanosine adducts of 1,2-naphthoquinone, an oxydated metabolite of naphthalene Synthesis and characterization of new DNA adduct with oxy-PAH: stable deoxyguanosine adducts of 7,12-benz[a]anthracenequinone Synthesis and characterization of new oxy-PAH-DNA adduct: stable deoxyguanosine adducts of 6H-benzo[cd]pyren-6-one." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC432.

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Les adduits à l'ADN sont considérés comme des biomarqueurs de génotoxicité particulièrement pertinents, puisqu’ils sont représentatifs de la structure du composé génotoxique. Nos recherches se sont axées sur les études de génotoxicité incluant l'altération de l'ADN en relation avec le risque de cancer, en se focalisant sur les dérivés des hydrocarbures aromatiques polycycliques (HAP). Des études de toxicité ont démontré que les HAP oxygénés (oxy-HAP) et les HAP nitrés (nitro-HAP) étaient responsables d'une grande partie de la toxicité totale des HAP. Ce travail s’est donc axé sur les oxy-HAP c

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Barrera, Esequiel Eduardo. "Synthesis and characterization of oligonucleotides containing deoxyxanthosine : a probe for the mutagentic and genotoxic activity of an oxidized DNA base." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/36650.

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Ji, Jiuping. "Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4." Thesis, 1990. http://hdl.handle.net/1957/36993.

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A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system, I investigated the molecular basis of mutations induced by imbalanced dNTP pools in vivo. Two approaches were adopted to disturb dNTP biosynthesis: 1) using mutations which affect the deoxyribonucleotide

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Rankin, Katherine M. "Structure and Properties of C8-Aryl-2'-Deoxyguanosine Adducts: From Mutagenic Lesions to Conformational Probes in Duplex DNA." Thesis, 2012. http://hdl.handle.net/10214/4935.

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A significant focus of toxicological research is the identification of electrophiles that covalently modify DNA to form addition products (adducts). These products can be generated when aryl radical species react at the C8-site of 2'-deoxyguanosine (dG) to form C8-aryl-dG adducts, which are mutagenic lesions. While this form of DNA modification is detrimental, C8-aryl-dG adducts also possess intriguing properties that can be exploited for beneficial purposes. This thesis is an investigation of one mechanism believed to contribute to the mutagenicity of C8-aryl-dG adducts, as well as a study

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Books on the topic "Mutagenic synthesis"

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Ronne, Erik. Synthesis of imidazoazaarenes. Swedish University of Agricultural Sciences, Dept. of Chemistry, 1994.

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Ji, Jiuping. Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4. 1990.

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Brooks, Michael E. Synthesis and reactivity of food derived promutagens and procarcinogens IQx and Trp-P-2. 2002.

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Book chapters on the topic "Mutagenic synthesis"

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Chandani, Sushil, and Edward L. Loechler. "Translesion Synthesis and Mutagenic Pathways in Escherichia coli Cells." In The Chemical Biology of DNA Damage. Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527630110.ch15.

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Kovala-Demertzi, Dimitra, Asimina Domopoulou, and Mavroudis A. Demertzis. "Synthesis, Spectroscopy and Structures of Complexes of PD(II) with 4N-Substituted Derivatives of 2-Acetylpyridine Thiosemicarbazone." In Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5780-3_29.

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Turhan, Munire. "Artificial Insemination in Honeybees." In Recent Applications and Biological Activities in Aquaculture and Agriculture. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359319.8.

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Xenobiotics are chemical substances that are not naturally found in the environment but are introduced through human activities. These substances include pesticides, pharmaceuticals, industrial chemicals, and various synthetic compounds. The presence of xenobiotics in the environment has diverse and often detrimental effects on ecosystems and biodiversity. Xenobiotics can lead to water pollution, adversely affecting aquatic organisms. Fish and other aquatic life exposed to these chemicals may experience reproductive, growth, and behavioural issues. Accumulation of xenobiotics in soil can harm

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"DNA translesion synthesis in cellular response to oxidative stress and ionizing radiation." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.4.6.

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Oxidative stress and ionizing radiation is a source of DNA damage causing replication stress, mutagenesis and cell death. The DNA damage response (DDR) includes evolutionarily conserved mechanisms of DNA repair (such as base excision repair and homologues recombination) and DNA translesion synthesis. We analyzed the mutagenic and cytotoxic potential of 8-oxoguanine (8-oxoG) and 8- oxoadenine (8-oxoA) – two major DNA lesions caused by reactive oxygen species. We carried out DNA polymerase reactions with five human DNA polymerases involved in base excision repair (Pol beta, Pol lambda), DNA tran

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Craig, Nancy L., Rachel Green, Carol Greider, Gisela Storz, Cynthia Wolberger, and Orna Cohen-Fix. "Repair of DNA double-strand breaks and homologous recombination." In Molecular Biology. Oxford University Press, 2021. http://dx.doi.org/10.1093/hesc/9780198788652.003.0016.

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This chapter examines the repair of DNA double-strand breaks and homologous recombination. DNA double-strand breaks are particularly dangerous lesions—failure to repair them can lead to chromosome fragmentation and cell death. There are two major strategies for double-strand break repair: non-homologous end joining (NHEJ) and homology-directed repair. NHEJ rejoins the ends across a double-strand break in the absence of a DNA template. It is often mutagenic because of nucleolytic processing of the ends prior to joining. Meanwhile, homology-directed DNA synthesis can repair double-strand breaks

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K. Tebbi, Cameron, Ioly Kotta-Loizou, and Robert H.A. Coutts. "Mycovirus Containing Aspergillus flavus and Acute Lymphoblastic Leukemia: Carcinogenesis beyond Mycotoxin Production." In The Genus Aspergillus - Pathogenicity, Mycotoxin Production and Industrial Applications [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98897.

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Carcinogenic effects of Aspergillus spp. have been well established and generally attributed to a variety of mycotoxin productions, particularly aflatoxins. It is known that most carcinogenic mycotoxins, with the exception of fumonisins, are genotoxic and mutagenic, causing chromosomal aberrations, micronuclei, DNA single-strand breaks, sister chromatid exchange, unscheduled DNA synthesis etc. Some Aspergillus spp. are infected with mycoviruses which can result in loss of aflatoxin production. The effects of mycovirus containing Aspergillus on human health have not been fully evaluated. Recent

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Correa, Gabriel Veloso, José Felipe Leite Ferreira Rosa, Stephanie Priscila de Sousa Cezário, et al. "TOXICOLOGICAL EVALUATION AND IN SILICO PHARMACOKINETICS OF CEFTIOFUR IN HUMAN AND ENVIRONMENTAL HEALTH." In Science and Connections: The Interdependence of Disciplines. Seven Editora, 2024. https://doi.org/10.56238/sevened2024.037-107.

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Ceftiofur is a broad-spectrum cephalosporin, effective against Gram-positive and Gram-negative pathogens. This antibiotic works by inhibiting the synthesis of the bacterial cell wall. Antibiotics, used in both human and veterinary medicine, are drugs of concern when found in the environment. This is due to the fact that, even at low concentrations, prolonged exposure to these residues can lead to the emergence of resistant bacteria, compromising human health and environmental balance. Direct or indirect contact, whether through the food chain, water resources or animal excreta, represent the m

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Santen, R. "The breast: lactation and breast cancer as an endocrine disease." In Oxford Textbook of Endocrinology and Diabetes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235292.003.0928.

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This chapter discusses both benign breast lesions and those that associated with an increased risk of breast cancer development, as well as the aetiology, clinical and pathologic prognosis, and hormonal treatment of breast cancers. Clinical observations in women suggest that hormones play a role in the aetiology of benign lesions. In postmenopausal women receiving oestrogens (with or without progestins) for more than 8 years, the prevalence of benign breast lesions is increased 1.7-fold; whilst the anti-oestrogen, tamoxifen, is associated with a 28 % reduction in prevalence of benign breast le

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Naha, Nibedita, and Gokul Manickavachagam. "Textile Industry and Health Hazards: Impact of Climate Change Issues and Fertility Potential." In Research Anthology on Advancements in Women's Health and Reproductive Rights. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-6299-7.ch033.

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Textile industry is one of the primarily concerned industries in the world generating huge revenues where both the skilled and unskilled labours are employed. Raw materials are mainly synthetic chemicals rather than the natural one. Several bleaching agents, additives are also used to get sufficiently high and uniform degree of whiteness in the textile materials. Environmental contamination is also common by the textile effluents. All these substances are mutagenic and carcinogenic, and cause enormous health hazards to humans, animals, and aquatic lives. Infertility, implantation failure, and

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Naha, Nibedita, and Gokul Manickavachagam. "Textile Industry and Health Hazards: Impact of Climate Change Issues and Fertility Potential." In Climate Change and Its Impact on Fertility. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4480-8.ch003.

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Textile industry is one of the primarily concerned industries in the world generating huge revenues where both the skilled and unskilled labours are employed. Raw materials are mainly synthetic chemicals rather than the natural one. Several bleaching agents, additives are also used to get sufficiently high and uniform degree of whiteness in the textile materials. Environmental contamination is also common by the textile effluents. All these substances are mutagenic and carcinogenic, and cause enormous health hazards to humans, animals, and aquatic lives. Infertility, implantation failure, and

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Conference papers on the topic "Mutagenic synthesis"

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Michel, Thibaut, Didier Gasparutto, Christine Saint-Pierre, and Jean Cadet. "Synthesis of O6-hydroxyethyl-2'-deoxyguanosine adducts containing oligonucleotides for the evaluation of their mutagenic features." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507343.

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Sathsarani, A. M. A. D., R. W. Mathangadeera, and K. K. D. S. Ranaweera. "Development of a Herbal Wine Using Cassia auriculata and Woodfordia fruticosa." In SLIIT International Conference on Advancements in Sciences and Humanities 2023. Faculty of Humanities and Sciences, SLIIT, 2023. http://dx.doi.org/10.54389/qscc4251.

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Wine is a popular alcoholic beverage that has been adored by people around the world for thousands of years. Herbal wine is a type of wine that is infused with medicinal herbs which enhances its flavor and adds to its health benefits. Herbal wine provides numerous health benefits, including a decrease in ovarian cancer, improved bone and skeleton strength, destruction of tumor cells, prevention of heart attacks by maintaining slender coronary arteries, and improved lung function. Herbs have potent anti-bacterial, anti mutagenic, and anti-microbial capabilities. This research aims to produce a

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Kupryashina, M. A., T. E. Pylaev, and V. E. Nikitina. "The influence of malachite green on the level of transcriptional expression of the laccase and DyP-peroxidase genes of the Azospirillum brasilense." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.142.

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Malachite green (MG), a widely-used and recalcitrant dye, has been confirmed to be carcinogenic and mutagenic against many organisms. Herein, we were aimed at the investigation of the hypothetic role of ligninolytic bacterial enzymes similar to fungal ones in the degradation of synthetic dyes. A multiple increase in the laccases and DyP-peroxidases genes expression level was recorded by RT-qPCR for bacteria of the genus Azospirillum in the presence of MG.

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LIUGĖ, Monika, and Dainius PALIULIS. "Evaluation of dynamic adsorption of dyes from aqueous solutions by applying mathematical modelling with the VS2TDI program and experimental studies." In 12th International Conference “Environmental Engineering”. VILNIUS TECH, 2023. http://dx.doi.org/10.3846/enviro.2023.935.

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Dyes, heavy metals, sulphates, chlorides, petroleum products and other substances can be found in industrial wastewater. Synthetic dyes are divided into different groups according to their chemical composition. It is known that synthetic dyes have toxic and mutagenic properties. Adsorption is considered a reliable method for the removal of various pollutants. The adsorbent synthesized from paper waste, which has a lot of air gaps in its composition, is called aerogel. The maximum sorption capacity reached the value of 0.25–0.28 and 0.12–0.16 mg/g. It is characterized by low density and large s

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Carvalho, Cristina, Marlene Couceiro, Gianni Montagna, Carla Costa Pereira, and Figueiredo Carlos. "Bio dyes and Bio pigments: the sustainable approach in industrial textile dyeing and printing processes." In 6th International Conference on Human Systems Engineering and Design Future Trends and Applications (IHSED 2024). AHFE International, 2024. http://dx.doi.org/10.54941/ahfe1005559.

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Unfortunately, The textile industry is a sector responsible for producing more than 2 billion tons of effluents/waste. A large part of the waste and effluents are discarded into the ecosystem, particularly in aquatic ecosystems, essentially after the finishing processes, which include dyeing and printing processes. Dyeing is one of the most polluting processes in the textile industry, representing a high source of pollution. According to the World Bank, the textile dyeing industries are responsible for more than 20% of the pollution of all water used at the industrial level. One of the serious

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Carvalho, Cristina, Carla Costa Pereira, Gianni Montagna, and Carlos Manuel Figueiredo. "Biodyes: a new approach in textile dyeing and printing technological processes." In 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003641.

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The textile industry is responsible for the production of more than 2 billion tons of effluents/waste, most of which are discarded into the ecosystem, namely and mostly into water ecosystems, essentially after the dyeing and printing processes. In fact, dyeing is one of the most polluting processes in the textile industry, representing a high source of pollution. According to the World Bank, the textile dyeing industries are responsible for more than 20% of the pollution of all water used at the industrial level.One of the serious problems related to the group of synthetic dyes is the level of

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