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Journal articles on the topic 'Mutagenic synthesis'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Tasleem, Faisal, Ayesha Bintay Farooq, Ijaz Ahmad, et al. "Assessment of Carcinogenic/Mutagenic Potential of Different Series of Synthetic Compounds." Haya: The Saudi Journal of Life Sciences 9, no. 07 (2024): 268–87. http://dx.doi.org/10.36348/sjls.2024.v09i07.005.

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The new drug research is usually based on synthesis medicine. The use of these medications has created problems such as tolerance in humans, for a long time and due to legitimate use of anti-infection, microbial defense against branded medication is growing. A mutagensis study by Ames in the early 1970's, used worldwide by drug and chemicals companies to diagnose mutagens carcinogenes, making it possible for them to be detected, and to be added to the mutagenic synthesis portion or radiation source triggering irreversible changes, and to the genetic material transmitted from the parent. deoxyr

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2

Kai, M. "Checkpoint activation regulates mutagenic translesion synthesis." Genes & Development 17, no. 1 (2003): 64–76. http://dx.doi.org/10.1101/gad.1043203.

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3

Jyotirmoy, Maity, Srivastava Smriti, Rana Rhea, Shankar Bhawani, Khanna Neena, and K. Prasad Ashok. "Biochemical synthesis of coumarin glycosides: A review." Journal of Indian Chemical Society Vol. 97, Feb 2020 (2020): 117–34. https://doi.org/10.5281/zenodo.5651400.

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Department of Chemistry, St. Stephen’s College, University of Delhi, Delhi-110 007, India Department of Chemistry, University of Delhi, Delhi-110 007, India Department of Chemistry, Shivaji College, University of Delhi, Delhi-110 027, India <em>E-mail:</em> ashokenzyme@gmail.com <em>Manuscript received online 11 October 2019, revised and accepted 14 December 2019</em> Coumarin glycosides have shown immense potential for diverse biological activities and have been explored extensively as highly prospective biomolecules. In recent years, coumarin glycosides have been used as enzyme inhibit

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4

Slameñová, Darina, Alena Gábelová, Katarina Ruppová, and Ladislave Wsólová. "Cytotoxic and Genotoxic Effects of Sodium Fluoride on Mammalian Cells at Neutral or Acid pH: A Summary of Published Work." Alternatives to Laboratory Animals 25, no. 3 (1997): 341–42. http://dx.doi.org/10.1177/026119299702500316.

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This paper forms a short review of some of our previously published work. We assessed the cytotoxic and genotoxic effects of sodium fluoride (NaF) on the Chinese hamster V79 cell line and the human EUE cell line at neutral and acid pH (as found in the stomach). The effects of NaF on cell proliferation, DNA synthesis, protein synthesis and mutagenesis were assessed. The results found showed no mutagenic effects after exposure to NaF, despite some cytogenic effects, suggesting that NaF probably does not represent any serious mutagenic or carcinogenic threat to humans.

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5

Kajimoto, Tetsuya, Manabu Node, Minoru Ozeki, Atsushi Muroyama, Tetsushi Watanabe, and Keiji Wakabayashi. "Synthesis of a New Mutagenic Benzoazepinoquinolinone Derivative." Synlett 2009, no. 11 (2009): 1781–84. http://dx.doi.org/10.1055/s-0029-1217358.

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6

Abdelnasser, Mohamed, Mark Hyland, and Neil D. Jespersen. "Synthesis of mutagenic compounds in crankcase oils." Environmental Science & Technology 20, no. 2 (1986): 145–49. http://dx.doi.org/10.1021/es00144a005.

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7

Saitkulova, F. G., I. I. Lapkin, T. S. Prokhorova, et al. "Synthesis, antimicrobial and mutagenic activity of ?-hydroxyketones." Pharmaceutical Chemistry Journal 19, no. 1 (1985): 41–43. http://dx.doi.org/10.1007/bf00767103.

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8

Nachtergael, Amandine, Déborah Lanterbecq, Martin Spanoghe, Alexandra Belayew, and Pierre Duez. "Effects of Chemopreventive Natural Compounds on the Accuracy of 8-oxo-7,8-dihydro-2′-deoxyguanosine Translesion Synthesis." Planta Medica 87, no. 10/11 (2021): 868–78. http://dx.doi.org/10.1055/a-1527-1435.

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AbstractTranslesion synthesis is a DNA damage tolerance mechanism that relies on a series of specialized DNA polymerases able to bypass a lesion on a DNA template strand during replication or post-repair synthesis. Specialized translesion synthesis DNA polymerases pursue replication by inserting a base opposite to this lesion, correctly or incorrectly depending on the lesion nature, involved DNA polymerase(s), sequence context, and still unknown factors. To measure the correct or mutagenic outcome of 8-oxo-7,8-dihydro-2′-deoxyguanosine bypass by translesion synthesis, a primer-extension assay

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9

Yudkina, Anna V., Anna A. Novikova, Anastasia D. Stolyarenko, Alena V. Makarova, and Dmitry O. Zharkov. "Bypass of Methoxyamine-Adducted Abasic Sites by Eukaryotic Translesion DNA Polymerases." International Journal of Molecular Sciences 26, no. 2 (2025): 642. https://doi.org/10.3390/ijms26020642.

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The apurinic/apyrimidinic site (AP site) is a highly mutagenic and cytotoxic DNA lesion. Normally, AP sites are removed from DNA by base excision repair (BER). Methoxyamine (MOX), a BER inhibitor currently under clinical trials as a tumor sensitizer, forms adducts with AP sites (AP-MOX) resistant to the key BER enzyme, AP endonuclease. As AP-MOX remains unrepaired, translesion DNA synthesis is expected to be the main mechanism of cellular response to this lesion. However, the mutagenic potential of AP-MOX is still unclear. Here, we compare the blocking and mutagenic properties of AP-MOX and th

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10

Choshi, Tominari, Akiko Tonari, Haruyuki Yoshioka, Kenichi Harada, Eiichi Sugino, and Satoshi Hibino. "Synthesis of mutagenic heterocyclic amines PhIP and DMIP." Journal of Organic Chemistry 58, no. 27 (1993): 7952–54. http://dx.doi.org/10.1021/jo00079a055.

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11

Shoji, Miki, Masa-Aki Mori, Michio Sayama, Hiroshi Kozuka, and Takashi Honda. "Synthesis of mutagenic 2,4-dinitro-[7-14C]benzaldehyde." Journal of Labelled Compounds and Radiopharmaceuticals 34, no. 7 (1994): 597–601. http://dx.doi.org/10.1002/jlcr.2580340703.

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12

Zhirnov, O. P., and A. I. Chernyshova. "Favipiravir: the hidden threat of mutagenic action." Journal of microbiology, epidemiology and immunobiology 98, no. 2 (2021): 213–20. http://dx.doi.org/10.36233/0372-9311-114.

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The antiviral drug favipiravir (FVP), which is a structural analogue of guanosine, undergoes chemical transformation in infected cells by cellular enzymes into a nucleotide form — favipiravir ribose triphosphate (FVPRTP). FVP-RTP is able to bind to viral RNA-dependent RNA polymerase and integrate into the viral RNA chain, causing a significant mutagenic effect through G→A and С→U transitions in the viral RNA genome. Besides the virus inhibiting effect, the increased synthesis of mutant virions under the action of FPV possess a threat of the emergence of novel threatening viral strains with hig

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13

Sikora, Karol, Piotr Szweda, Karolina Słoczyńska, et al. "Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides." Antibiotics 12, no. 5 (2023): 888. http://dx.doi.org/10.3390/antibiotics12050888.

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Eight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained. Their complete structure was confirmed using NMR spectroscopy (1H, 13C, COSY and HSQC) and high-resolution mass spectrometry (HRMS). An antimicrobial activity against fungi (Candida albicans, Candida glabrata) and bacteria (Staphylococcus aureus, Escherichia coli) and a mutagenic Ames test with Salmonella typhimurium TA 98 strain were performed for the obtained compounds. The greatest activity against the tested microorgani

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14

Sun, Yunkai, Xiaoxia Wu, Pei Zuo, et al. "Synthesis and mutagenic risk of avanafil's potential genotoxic impurities." RSC Advances 14, no. 30 (2024): 21432–38. http://dx.doi.org/10.1039/d4ra02345e.

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15

Nampalli, Satyam, and Shiv Kumar. "Efficient synthesis of 8-Oxo-dGTP: A mutagenic nucleotide." Bioorganic & Medicinal Chemistry Letters 10, no. 15 (2000): 1677–79. http://dx.doi.org/10.1016/s0960-894x(00)00310-3.

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16

Wojtaszek, Jessica L., Nimrat Chatterjee, Javaria Najeeb, et al. "A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy." Cell 178, no. 1 (2019): 152–59. http://dx.doi.org/10.1016/j.cell.2019.05.028.

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17

Lee-ruff, E., and H. Kruk. "Synthesis and Mutagenic Activity of Bay-Region Bridged Chrysenes." Polycyclic Aromatic Compounds 1, no. 4 (1990): 191–206. http://dx.doi.org/10.1080/10406639008034762.

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18

Joseph, Asha Mary, and Anjana Badrinarayanan. "Visualizing mutagenic repair: novel insights into bacterial translesion synthesis." FEMS Microbiology Reviews 44, no. 5 (2020): 572–82. http://dx.doi.org/10.1093/femsre/fuaa023.

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ABSTRACT DNA repair is essential for cell survival. In all domains of life, error-prone and error-free repair pathways ensure maintenance of genome integrity under stress. Mutagenic, low-fidelity repair mechanisms help avoid potential lethality associated with unrepaired damage, thus making them important for genome maintenance and, in some cases, the preferred mode of repair. However, cells carefully regulate pathway choice to restrict activity of these pathways to only certain conditions. One such repair mechanism is translesion synthesis (TLS), where a low-fidelity DNA polymerase is employe

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19

Maksimenko, L. V. "THE COMPARATIVE DESCRIPTION OF CHEMICAL SUBSTANCES BY THEIR DISTANT EFFECTS THAT ARE INTRODUCED TO THE ANIMALS’ ORGANISM BY MEANS OF INHALATION." I.P.Pavlov Russian Medical Biological Herald 14, no. 1 (2006): 5. http://dx.doi.org/10.17816/pavlovj201716-13.

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The article is devoted to the study of toxicological effect of a number of pesticides and inters of their synthesis upon experimental animals` organisms: white mice, Black -6 mice and white rats. The author also investigates mutagenic and gonadotoxic effects.

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20

Overmeer, René M., Jill Moser, Marcel Volker, et al. "Replication protein A safeguards genome integrity by controlling NER incision events." Journal of Cell Biology 192, no. 3 (2011): 401–15. http://dx.doi.org/10.1083/jcb.201006011.

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Single-stranded DNA gaps that might arise by futile repair processes can lead to mutagenic events and challenge genome integrity. Nucleotide excision repair (NER) is an evolutionarily conserved repair mechanism, essential for removal of helix-distorting DNA lesions. In the currently prevailing model, NER operates through coordinated assembly of repair factors into pre- and post-incision complexes; however, its regulation in vivo is poorly understood. Notably, the transition from dual incision to repair synthesis should be rigidly synchronized as it might lead to accumulation of unprocessed rep

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21

Saribasak, Huseyin, Deepa Rajagopal, Robert W. Maul, and Patricia J. Gearhart. "Hijacked DNA repair proteins and unchained DNA polymerases." Philosophical Transactions of the Royal Society B: Biological Sciences 364, no. 1517 (2008): 605–11. http://dx.doi.org/10.1098/rstb.2008.0188.

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Somatic hypermutation of immunoglobulin (Ig) genes occurs at a frequency that is a million times greater than the mutation in other genes. Mutations occur in variable genes to increase antibody affinity, and in switch regions before constant genes to cause switching from IgM to IgG. Hypermutation is initiated in activated B cells when the activation-induced deaminase protein deaminates cytosine in DNA to uracil. Uracils can be processed by either a mutagenic pathway to produce mutations or a non-mutagenic pathway to remove mutations. In the mutagenic pathway, we first studied the role of misma

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22

Kozmin, Stanislav G., Igor B. Rogozin, Elizabeth A. Moore, Mariah Abney, Roel M. Schaaper, and Youri I. Pavlov. "Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al." Science Advances 5, no. 9 (2019): eaaw3915. http://dx.doi.org/10.1126/sciadv.aaw3915.

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A recent article in Science Advances described the striking discovery that the commensal Staphylococcus epidermidis strain MO34 displays antimicrobial and antitumor activities by producing a small molecule, identified as the nucleobase analog 6-N-hydroxylaminopurine (6-HAP). However, in contradiction to the literature, the authors claimed that 6-HAP is nonmutagenic and proposed that the toxic effect of 6-HAP results from its ability to inhibit, in its base form, DNA synthesis. To resolve the discrepancy, we proved by genetic experiments with bacteria and yeast that extracts of MO34 do contain

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23

Hubanova, Yu S. "Evaluation of informativeness of mutation groups of Nigella damascena L. M2 generation." Plant varieties studying and protection 19, no. 1 (2023): 15–23. http://dx.doi.org/10.21498/2518-1017.19.1.2023.277767.

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Purpose. To carry out a mathematical and statistical evaluation of the mutagenesis data of the M2 generation of Nigella damascena varieties ‘Berehynia’ and ‘Charivnytsia’ in order to identify relationships between groups of mutations and mathematical justification of their use in the process of further analysis and selection of hereditary changes of mutant plants. Methods. Seeds of the varieties ‘Berehynia’ and ‘Charivnytsia’ were treated with chemical mutagens. The mutations identified by visual observation of the plants at different stages of their growth and development were divided into ei

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24

Sotomayor, Rene E., and Thomas F. X. Collins. "Mutagenicity, Metabolism, and DNA Interactions of Urethane." Toxicology and Industrial Health 6, no. 1 (1990): 71–108. http://dx.doi.org/10.1177/074823379000600106.

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Urethane, a known animal carcinogen, has been the subject of intensive research efforts spanning 40 years. Recent concerns have focused on the presence of urethane in a variety of fermented foods and alcoholic beverages, although no epidemiological studies or human case reports have been published. Much information is available about the mutagenesis, metabolism, and DNA interactions of urethane in experimental systems. Urethane is generally not mutagenic in bacteria although in some instances it acts as a weak mutagen. Urethane is not mutagenic in Neurospora but is weakly mutagenic in Saccharo

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25

Shalom, Yosef, Ronald G. Harvey, and Jochanan Blum. "Synthesis of nucleoside adducts of highly mutagenic polycyclic aromatic imines." Tetrahedron 55, no. 33 (1999): 10231–42. http://dx.doi.org/10.1016/s0040-4020(99)00549-9.

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26

Seidel, A., H. R. Glatt, F. Oesch, and P. Garrigues. "2,9-Dimethylpicene: Synthesis, Mutagenic Activity, and Identification in Natural Samples." Polycyclic Aromatic Compounds 1, no. 1-2 (1990): 3–14. http://dx.doi.org/10.1080/10406639008034744.

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27

CHOSHI, T., A. TONARI, H. YOSHIOKA, K. HARADA, E. SUGINO, and S. HIBINO. "ChemInform Abstract: Synthesis of Mutagenic Heterocyclic Amines PhIP and DMIP." ChemInform 25, no. 20 (2010): no. http://dx.doi.org/10.1002/chin.199420191.

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28

Schroeder, Jeremy W., Justin R. Randall, William G. Hirst, Michael E. O’Donnell, and Lyle A. Simmons. "Mutagenic cost of ribonucleotides in bacterial DNA." Proceedings of the National Academy of Sciences 114, no. 44 (2017): 11733–38. http://dx.doi.org/10.1073/pnas.1710995114.

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Replicative DNA polymerases misincorporate ribonucleoside triphosphates (rNTPs) into DNA approximately once every 2,000 base pairs synthesized. Ribonucleotide excision repair (RER) removes ribonucleoside monophosphates (rNMPs) from genomic DNA, replacing the error with the appropriate deoxyribonucleoside triphosphate (dNTP). Ribonucleotides represent a major threat to genome integrity with the potential to cause strand breaks. Furthermore, it has been shown in the bacteriumBacillus subtilisthat loss of RER increases spontaneous mutagenesis. Despite the high rNTP error rate and the effect on ge

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29

Lee, Young-Sam, Yang Gao, and Wei Yang. "How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis." Nature Structural & Molecular Biology 22, no. 4 (2015): 298–303. http://dx.doi.org/10.1038/nsmb.2985.

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30

Maki, Hisaji, and Mutsuo Sekiguchi. "MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis." Nature 355, no. 6357 (1992): 273–75. http://dx.doi.org/10.1038/355273a0.

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31

Thompson, Scott K., and Clayton H. Heathcock. "Total synthesis of (.+-.)-isovelleral, a mutagenic sesquiterpene dialdehyde from Lactarius vellereus." Journal of Organic Chemistry 55, no. 10 (1990): 3004–5. http://dx.doi.org/10.1021/jo00297a009.

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32

Vartanyan, R. S., R. S. Shaginyan, Zh V. Kazaryan, G. M. Paronikyan, T. P. Sarkisyan, and S. A. Vartanyan. "Synthesis and mutagenic action of tetrahydropyranyl-and tetrahydrothiopyranyl pyrazoles and pyrimidines." Pharmaceutical Chemistry Journal 22, no. 4 (1988): 292–96. http://dx.doi.org/10.1007/bf00768246.

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33

Fabrega, Carme, Ramon Eritja, Nanda D. Sinha, Manjit K. Dosanjh, and Bea Singer. "Synthesis and properties of oligonucleotides containing the mutagenic base O4-benzylthymidine." Bioorganic & Medicinal Chemistry 3, no. 1 (1995): 101–8. http://dx.doi.org/10.1016/0968-0896(94)00148-v.

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34

Matsuda, Akira, and Tohru Ueda. "The Synthesis, Mutagenic and Pharmacological Activities of 2-Carbon-Substituted Adenosines." Nucleosides and Nucleotides 6, no. 1-2 (1987): 85–94. http://dx.doi.org/10.1080/07328318708056182.

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35

Parry, T. E. "Two possible metabolic blocks in DNA synthesis that could be mutagenic." Leukemia Research 18, no. 3 (1994): 229. http://dx.doi.org/10.1016/0145-2126(94)90119-8.

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36

Yamanaka, Kinrin, Nimrat Chatterjee, Michael T. Hemann, and Graham C. Walker. "Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?" PLOS Genetics 13, no. 8 (2017): e1006842. http://dx.doi.org/10.1371/journal.pgen.1006842.

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37

Elmegeed, Gamal A., Wagdy K. B. Khalil, Amira Abdel Raouf, and Mervat M. Abdelhalim. "Synthesis and in vivo anti-mutagenic activity of novel melatonin derivatives." European Journal of Medicinal Chemistry 43, no. 4 (2008): 763–70. http://dx.doi.org/10.1016/j.ejmech.2007.06.003.

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38

Nampalli, Satyam, and Shiv Kumar. "ChemInform Abstract: Efficient Synthesis of 8-Oxo-dGTP: A Mutagenic Nucleotide." ChemInform 31, no. 44 (2000): no. http://dx.doi.org/10.1002/chin.200044232.

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39

Gening, Leonid, Oleg Shevchenko, Konstantin Kazachenko, and Vyacheslav Tarantul. "“Mirror” Method to Estimate Mutagenic Activity of DNA Lesions." Methods and Protocols 1, no. 3 (2018): 32. http://dx.doi.org/10.3390/mps1030032.

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We propose an improved method for detecting mutations that arise in DNA due to misincorporations of deoxyadenosine-5′-monophosphate (dAMP) opposite 7,8-dihydro-8-oxoguanine (8-oxoG). The method is based on the synthesis of complementary chains (“mirror” products) using a template containing 8-oxoG. The misincorporation of dAMP in the “mirror” product forms EcoRI sites. The restriction analysis of double-stranded DNAs obtained by PCR of “mirror” product allows quantification of the mutagenesis frequency. In addition, single-strand conformational polymorphism (SSCP) analysis of the single-strand

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40

Kienesberger, Sabine, Amar Cosic, Maksym Kitsera, et al. "Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice." Nature Microbiology 7, no. 11 (2022): 1834–48. http://dx.doi.org/10.1038/s41564-022-01260-3.

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AbstractKlebsiella spp. that secrete the DNA-alkylating enterotoxin tilimycin colonize the human intestinal tract. Numbers of toxigenic bacteria increase during antibiotic use, and the resulting accumulation of tilimycin in the intestinal lumen damages the epithelium via genetic instability and apoptosis. Here we examine the impact of this genotoxin on the gut ecosystem. 16S rRNA sequencing of faecal samples from mice colonized with Klebsiella oxytoca strains and mechanistic analyses show that tilimycin is a pro-mutagenic antibiotic affecting multiple phyla. Transient synthesis of tilimycin in

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41

Torres-Ramos, Carlos A., Satya Prakash, and Louise Prakash. "Requirement of RAD5 and MMS2 for Postreplication Repair of UV-Damaged DNA in Saccharomyces cerevisiae." Molecular and Cellular Biology 22, no. 7 (2002): 2419–26. http://dx.doi.org/10.1128/mcb.22.7.2419-2426.2002.

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ABSTRACT UV lesions in the template strand block the DNA replication machinery. Genetic studies of the yeast Saccharomyces cerevisiae have indicated the requirement of the Rad6-Rad18 complex, which contains ubiquitin-conjugating and DNA-binding activities, in the error-free and mutagenic modes of damage bypass. Here, we examine the contributions of the REV3, RAD30, RAD5, and MMS2 genes, all of which belong to the RAD6 epistasis group, to the postreplication repair of UV-damaged DNA. Discontinuities, which are formed in DNA strands synthesized from UV-damaged templates, are not repaired in the

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42

Rodriguez-Alvarez, Marta, Daria Kim, and Andriy Khobta. "EGFP Reporters for Direct and Sensitive Detection of Mutagenic Bypass of DNA Lesions." Biomolecules 10, no. 6 (2020): 902. http://dx.doi.org/10.3390/biom10060902.

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The sustainment of replication and transcription of damaged DNA is essential for cell survival under genotoxic stress; however, the damage tolerance of these key cellular functions comes at the expense of fidelity. Thus, translesion DNA synthesis (TLS) over damaged nucleotides is a major source of point mutations found in cancers; whereas erroneous bypass of damage by RNA polymerases may contribute to cancer and other diseases by driving accumulation of proteins with aberrant structure and function in a process termed “transcriptional mutagenesis” (TM). Here, we aimed at the generation of repo

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43

Nogi, Yuhei, Noriko Saito-Tarashima, Sangita Karanjit, and Noriaki Minakawa. "Synthesis and Behavior of DNA Oligomers Containing the Ambiguous Z-Nucleobase 5-Aminoimidazole-4-carboxamide." Molecules 28, no. 7 (2023): 3265. http://dx.doi.org/10.3390/molecules28073265.

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5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide 5′-monophosphate (ZMP) is a central intermediate in de novo purine nucleotide biosynthesis. Its nucleobase moiety, 5-aminoimidazole-4-carboxamide (Z-base), is considered an ambiguous base that can pair with any canonical base owing to the rotatable nature of its 5-carboxamide group. This idea of ambiguous base pairing due to free rotation of the carboxamide has been applied to designing mutagenic antiviral nucleosides, such as ribavirin and T-705. However, the ambiguous base-pairing ability of Z-base has not been elucidated, because the synthe

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44

Singh, Parkash, Parminder Kaur Narang, and Akanksha . "A Review on Toxicity and Degradation of Ethidium Bromide (EtBr)." Environment and Ecology 42, no. 2B (2024): 851–54. http://dx.doi.org/10.60151/envec/kwjt3358.

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Ethidium bromide (EtBr) serves as an interpolating agent utilized for its fluorescent properties in gel electrophoresis, aiding in the detection of various DNA fragments. However, its usage has been associated with DNA mutations, inhibition of mitochondrial protein synthesis and other alterations, particularly at high concentrations. Due to its remarkable stability in the environment and propensity to degrade into mutagenic compounds, especially when exposed to bleaching agents, there are significant concerns regarding its widespread use. Given the potential toxic and mutagenic effects of EtBr

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45

Jansen, Jacob G., Anastasia Tsaalbi-Shtylik, and Niels de Wind. "Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease." DNA Repair 29 (May 2015): 56–64. http://dx.doi.org/10.1016/j.dnarep.2015.01.001.

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46

Manucharyan, G. I., G. A. Darbinyan, G. M. Paronikyan, and A. O. Tosunyan. "Synthesis and mutagenic and antimutagenic activity of substituted 2,2-dimethyltetrahydropyranopyrazolines and pyrazoles." Pharmaceutical Chemistry Journal 24, no. 7 (1990): 477–81. http://dx.doi.org/10.1007/bf00764995.

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47

Chatterjee, Nimrat, Sanjay D'Souza, Mohammad Shabab та ін. "A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis". Environmental and Molecular Mutagenesis 61, № 8 (2020): 830–36. http://dx.doi.org/10.1002/em.22395.

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48

Ouanes-Ben Othmen, Z., S. Essefi, and H. Bacha. "Mutagenic and epigenetic mechanisms of zearalenone: prevention by Vitamin E." World Mycotoxin Journal 1, no. 3 (2008): 369–74. http://dx.doi.org/10.3920/wmj2008.1036.

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It has been suggested that zearalenone, a non-steroidal estrogenic mycotoxin produced by Fusarium graminearium, causes DNA damage. However, the mutagenic properties of this toxin are controversial. The purpose of this study was to investigate both genotoxic and epigenetic effects of zearalenone in vitro. The effects of zearalenone on unscheduled DNA synthesis (UDS), induction of chromosome aberrations and inhibition of gap junctional intercellular communication were determined using Vero cells. The results show that in Vero cells, zearalenone treatment caused a concentration-dependent increase

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Mitchell, Reginald H., Mahima Chaudhary, Richard Vaughan Williams, et al. "Straining strained molecules. III. The spectral and mutagenic properties and an alternate synthesis of diaceperylene and dicyclopenta[1,2,3-cd:1′,2′,3′-lm]perylene." Canadian Journal of Chemistry 70, no. 4 (1992): 1015–21. http://dx.doi.org/10.1139/v92-135.

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The synthesis of diaceperylene (1) from 5,6-dilithioacenaphthene via nickel or cobalt catalysed couplings proceeded in better yield than a multistep synthesis involving formation of 5,5′-diacenaphthene first. Dehydrogenation of 1 to dicyclopenta[1,2,3-cd:1′,2′,3′-lm]perylene (2) proved a better route than coupling of 5,6-disubstituted acenaphthylene derivatives. Ultraviolet, proton, and carbon nuclear magnetic resonance spectra and electrode reduction potential data of 1 and 2 are discussed with respect to molecular mechanics calculations of strain in these and related bridged naphthalenes. Bo

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Yu., S. Hubanova. "Evaluation of informativeness of mutation groups of Nigella damascena L. M2 generation." Plant varieties studying and protection 19, no. 1 (2023): 15–23. https://doi.org/10.21498/2518-1017.19.1.2023.277767.

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<strong>Purpose.</strong> To carry out a mathematical and statistical evaluation of the mutagenesis data of the M<sub>2</sub> generation of <em>Nigella damascena</em> varieties ‘Berehynia’ and ‘Charivnytsia’ in order to identify relationships between groups of mutations and mathematical justification of their use in the process of further analysis and selection of hereditary changes of mutant plants. <strong>Methods.</strong> Seeds of the varieties ‘Berehynia’ and ‘Charivnytsia’ were treated with chemical mutagens. The mu

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