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Dissertations / Theses on the topic 'Mutagens'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Papaparaskeva-Petrides, Christina. "Mutagens in edible mushrooms." Thesis, University of Surrey, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314464.

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2

Schuisky, Peter. "Synthesis of metal complexes and potential food mutagens /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1998. http://epsilon.slu.se/avh/1998/91-576-5517-0.gif.

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3

Ayrton, Andrew David. "Food mutagens : factors that modulate their metabolic activation." Thesis, University of Surrey, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328576.

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4

Kanungnit, Pupatwibul Brockman Herman E. "Effects of six dietary antimutgen[sic] on the mutagenicity of five dietary mutagens in Salmonella typhimurium strains TA98 and SV50." Normal, Ill. Illinois State University, 1992. http://wwwlib.umi.com/cr/ilstu/fullcit?p9234467.

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Thesis (Ph. D.)--Illinois State University, 1992.<br>Title from title page screen, viewed January 30, 2006. Dissertation Committee: Herman E. Brockman (chair), Alan J. Katz, Brian J. Wilkinson, Lynne A. Lucher, Radheshaym Jayaswal. Includes bibliographical references (leaves 115-123) and abstract. Also available in print.

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5

Tippins, T. A. "Various factors which affect the response of yeast cells to environmental mutagens." Thesis, Swansea University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639246.

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This project investigates the factors which may affect the response of yeast cells to potential mutagens and thus to optimise their response. The problem was approached from four main angles as follows: i) permeability - rendering the cells more permeable either by pre-treatment with selected chemicals or by selecting clones with cell wall defects; ii) repair capacity - preventing adequate repair of damaged DNA either by post-treatment with repair inhibitors or by using strains with defective repair genes; iii) genetic background - looking at reversion in the same gene but in a different genet

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6

Howes, A. J. "In vitro and in vivo studies of mutagens found in cooked food." Thesis, University of Surrey, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378734.

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7

Manna, David. "Mutational analysis of the central channel in the Simian virus 40 large T antigen helicase." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 2.82 Mb., 110 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1435876.

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8

Sedijani, Prapti, of Western Sydney Hawkesbury University, of Science Technology and Agriculture Faculty, and School of Horticulture. "The use of mutagenic agents to increase the protein content and improve the amino acid composition of sweet potato (Ipomea batatas Lam.)." THESIS_FSTS_HOR_Sedijani_P.xml, 1997. http://handle.uws.edu.au:8081/1959.7/647.

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The sweet potato has become a major international crop and it is also the main staple food for many people in the developing world. This crop is desirable as it is high yielding, easy to grow and has a low cost of production. However, the tubers have a low protein content and a low concentration of amino acids, particularly the aspartate amino acid. This has contributed to malnutrition in some areas. To help overcome this problem this study had the aim of producing lines of sweet potato with increased nutritional values. Two varieties, Beauregard and LO322, were selected for study as they have

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9

Cabrera, Guillermo Lopez Brockman Herman E. "Effect of five dietary antimutagens on the genotoxicity of six mutagens using three different short-term tests." Normal, Ill. Illinois State University, 1993. http://wwwlib.umi.com/cr/ilstu/fullcit?p9416862.

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Thesis (Ph. D.)--Illinois State University, 1993.<br>Title from title page screen, viewed March 7, 2006. Dissertation Committee: Herman E. Brockman (chair), Alan J. Katz, Brian J. Wilkinson, David F. Weber, Radheshyam K. Jayaswal. Includes bibliographical references (leaves 162-177) and abstract. Also available in print.

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10

Donnelly, Eilish Teresa. "An investigation of DNA repair in wild-type, amino acid auxotrophs and UV-sensitive mutants of Aspergillus nidulans." Thesis, University of Ulster, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243733.

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11

Shanks, Thomas Gordon. "The epidemiology of mutagens : evidence of cumulative genetic damage in the mortality rates of former smokers /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3167831.

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12

Gallampois, Christine [Verfasser]. "Integrated biological-chemical approach for the identification of polyaromatic mutagens in surface waters / Christine Gallampois." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1044491787/34.

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13

Cosentino, Lidia. "A comparison of transgenic and endogenous loci in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/NQ56223.pdf.

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14

Hallgren, Jenny. "The role of heparin in the activation of mast cell tryptase /." Uppsala : Dept. of Molecular Biosciences, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/v179.pdf.

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15

Yu, Hongbin Yu Hongbin. "Part I, Nitrosation of amidines : structure and reactivity ; Part 2, Aldehyde mediated nitrosation of amino acids ; Part 3, Thermal decomposition of N-nitrosocarboxylic acids /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3052235.

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16

Durant, John Laighton. "Detection and identification of human cell mutagens in sediments and surface waters of the Aberjona watershed." Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/12461.

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17

Keir, Jennifer Leslie Ann. "The Use of Urinary Biomarkers to Assess Exposures to Polycyclic Aromatic Hydrocarbons (PAHs) and Other Organic Mutagens." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36114.

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Exposure to combustion emissions poses a threat to human health due to the complex mixture of toxic compounds. Polycyclic aromatic hydrocarbons (PAHs) are one group of compounds found within this mixture, and have known carcinogenic and mutagenic properties. Rates of exposure to PAHs depend on a wide range of variables including, but not limited to, demographic, geographical location, dietary habits, smoking habits, and occupation. Understanding magnitude of exposure to these compounds in various groups is imperative to highlight at-risk populations and provide appropriate exposure reduction r

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18

Orrhage, Kerstin. "Impact of Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microflora and bioavailability of some food mutagens /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3687-0/.

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19

Maddox, Catherine Michael. "Genotoxicity of 4-monochlorobiphenyl in the lung of transgenic male 344 Fisher rats." Thesis, University of Iowa, 2007. http://ir.uiowa.edu/etd/155.

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20

Pritchett, Blair. "Mutagenic and genotoxic potential of nitrated polyaromatic hydrocarbons in combustion byproduct mixtures." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0021/MQ55538.pdf.

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21

Obinaju, Blessing. "Application of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy to measure sub-lethal effects of potential mutagens." Thesis, Lancaster University, 2015. http://eprints.lancs.ac.uk/76562/.

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Techniques employed in vibrational spectroscopy monitor the vibrational modes of functional groups within biomolecules and enable a correlation between chemical information and histological structures. Interrogation of biological samples using infrared (IR) techniques generates spectrum with wavenumber-absorbance intensities specific to biomolecules within the sample. Methods are relatively non-destructive, and so samples can subsequently be analyzed by more conventional approaches. Analyses can be carried out ex vivo or in situ in living tissue, where a reference range of a designated normal

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22

Henderson, Daryl Stewart. "A genetic analysis of mutagen-sensitive mutations on the second chromosome of Drosophila melanogaster." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26418.

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Mutagen-sensitive (mus) mutations in Drosophila melanogaster render developing flies hypersensitive to the lethal effects of DNA-damaging agents. In general, mus mutations identify DNA repair-related genes. In this study, 5 new second chromosome mus mutations (mus205B¹, mus208B¹, mus209B¹, mus210B¹ and mus211B¹), selected on the basis of sensitivity to methyl methanesulfonate (MMS), were characterized using a variety of genetic tests. One test measured the MMS-sensitivity of double mutant mus strains compared to their component single mutants. Mutant interactions were examined in 8 double mus

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23

Ngsee, Johnny Kuan. "Cassette mutagenic analysis of the signal peptide of yeast invertase." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/27500.

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The SUC2 locus of Saccharomyces cerevisiae encodes two forms of invertase; a constitutively expressed cytoplasmic enzyme and a glucose-repressible secreted and glycosylated enzyme which is initially produced with an amino-terminal signal peptide. The coding sequence of the SUC2 locus has been placed under the control of the constitutive ADH1 promoter and transcription terminator in a centromere based yeast plasmid vector from which invertase is expressed in a Sue" strain of yeast. Oligonucleotide-directed mutagenesis has been used to create a PstI site in the gene at the point encoding the sig

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24

Pettersson-Strömbäck, Anita. "Chemical exposure in the work place : mental models of workers and experts /." Umeå : Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1646.

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25

Han, Jin-Soon Brockman Herman E. "Effects of active oxygen species generated from hydrogen peroxide in Neurospora crassa and Salmonella typhimurium." Normal, Ill. Illinois State University, 1991. http://wwwlib.umi.com/cr/ilstu/fullcit?p9203030.

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Thesis (Ph. D.)--Illinois State University, 1991.<br>Title from title page screen, viewed December 8, 2005. Dissertation Committee: Herman E. Brockman (chair), Radheshym K. Jayaswal, Alan J. Katz, David F. Weber, Brian J. Wilkinson. Includes bibliographical references (leaves 113-125) and abstract. Also available in print.

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26

Prapti, Sedijani. "The use of mutagenic agents to increase the protein content and improve the amino acid composition of sweet potato (Ipomea batatas Lam.) /." View thesis View thesis, 1997. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030925.092030/index.html.

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Thesis (M. Sc.) (Hons.) -- University of Western Sydney, Hawkesbury, 1997.<br>Thesis submitted for the degree of Master of Science (Honours), School of Horticulture, University of Western Sydney, Hawkesbury, 1997. In Chapter 1, figures 1.1 and 1.2 are not reproduced in the text. Bibliography : leaves 112-135.

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27

Perera, Anthonige Vidya. "Genes Affecting the Repair and Survival of Escherichia coli Following Psoralen-Induced Damage: a DNA Interstrand Crosslinking Agent." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2195.

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Photoactivated psoralens and other agents that form DNA interstrand crosslinks are highly cytotoxic and are useful in treating a range of diseases, including vitiligo, psoriasis, and some forms of cancer. Unlike many lesions that damage only one strand of the duplex DNA, DNA interstrand crosslinks form covalent bonds with both strands. Thus, repairing these lesions is complicated both by the lack of an undamaged strand to serve as a template for resynthesis following excision, as well as the potential to form double strand breaks if both strands are incised. A number of models have proposed th

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28

Kurzawa-Zegota, Malgorzata. "In vitro chemically-induced DNA damage in cancer patients and healthy individuals : the effect of genotoxic compounds in cells from polyposis coli, colon cancer patients and healthy individuals." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5186.

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In the present study DNA damage was measured in peripheral blood lymphocytes from polyposis coli and colorectal cancer patients, treated with different dietary and environmental compounds and compared with lymphocytes from healthy individuals. In addition, confounding factors such as age, gender, alcohol intake and smoking habits were taken into consideration. The assays used in this study included the Comet assay, the Micronucleus assay, the Micronucleus-FISH assay and the sister chromatid exchange assay. The food mutagens, PhIP and IQ, as well as titanium dioxide nanoparticles (TiO2 NPs) ind

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29

Andrieux, Florian. "Rôle de la protéine PB1 dans la fidélité du complexe polymérase des virus influenza." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC216/document.

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Les virus influenza de type A (IAV) appartiennent à la famille des Orthomyxoviridae. Ces virus enveloppés présentent un génome composé de 8 segments d’ARN simple brin, de polarité négative. Chaque segment est encapsidé par les nucléoprotéines (NP) et associé au complexe polymérase viral, hétérotrimère composé des sous-unités PB1, PB2 et PA, pour former la ribonucléoprotéine virale (RNPv). La protéine PB1 est la sous-unité catalytique responsable de l’activité ARN polymérase ARN-dépendante du complexe viral. La RNPv représente ainsi l’unité minimale de transcription et réplication du génome vir

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30

Prince, Polly Rodgers. "Molecular basis for genetic instability in Werner syndrome /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/6323.

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31

Cox, Julie. "Evaluation of Strategies to Improve In Vitro Mutagenicity Assessment: Alternative Sources of S9 Exogenous Metabolic Activation and the Development of an In Vitro Assay Based on MutaMouse Primary Hepatocytes." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39340.

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In vitro genetic toxicity tests using cultured bacterial or mammalian cells provide a cost- and time-effective alternative to animal tests. Unfortunately, existing in vitro assays are not always reliable. This is in part due to the limited metabolic capacity of the cells used, which is often critical to accurately assess chemical genotoxicity. This limited metabolic capacity necessitates the use of exogenous sources of mammalian metabolic enzymes that can simulate in vivo mammalian metabolic activation reactions. In response to this, and other limitations, alongside the worldwide trend to redu

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32

BOUDSOCQ, FRANCOIS. "Mecanismes moleculaires de la mutagenese sos chez escherichia coli : interactions entre le complexe mutagene umud'c et le polymere reca." Paris 11, 1998. http://www.theses.fr/1998PA112017.

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Les lesions du genome provoquees par les cancerigenes physiques ou chimiques sont responsables des mutations induites. L'apparition des mutations est avant tout le resultat d'une replication fautive operee par l'adn-polymerase sur un adn portant des lesions. Chez la bacterie ou le mecanisme de la mutagenese est le mieux connu, la proteine reca et le complexe umud'c sont deux facteurs essentiels de la mutagenese. Le polymere reca servirait a presenter le complexe umud'c au niveau de la lesion, celui-ci pourrait alors interagir avec la polymerase et l'aider a poursuivre la synthese a travers la

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33

Herrmann, Jean-Louis. "Etude de la virulence de "Yersinia pseudotuberculosis" par mutagène par transposition." Paris 5, 1989. http://www.theses.fr/1989PA05P158.

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34

Duarte, Jonathaline Apollo. "Avaliação imunotoxicológica da anacauíta (Schinus molle l.) em cultura celular." Universidade Federal do Pampa, 2016. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/1649.

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Submitted by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2017-06-12T14:17:48Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) JONATHALINE APOLLO DUARTE.pdf: 1033426 bytes, checksum: 65249cf69187d253ce4462e7152ce8db (MD5)<br>Approved for entry into archive by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2017-06-12T14:18:00Z (GMT) No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) JONATHALINE APOLLO DUARTE.pdf: 1033426 bytes, checksum: 65249cf69187d253ce4462e7152ce8db (MD5)<br>Made availa

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35

Moliterno, Enrique Alfredo Parachu. "Variabilidade genética e a eficiência de seleção no caráter dormência de sementes em aveia-preta(Avena strigosa Schreb.)." Universidade Federal de Pelotas, 2008. http://repositorio.ufpel.edu.br/handle/ri/1458.

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Made available in DSpace on 2014-08-20T13:44:39Z (GMT). No. of bitstreams: 1 tese_enrique_parachu_moliterno.pdf: 1249954 bytes, checksum: 934585fa055374ac866ea4a1bfb4b4e1 (MD5) Previous issue date: 2008-02-28<br>Seed dormancy is a trait shown by a large variety of weedy plants, which helps the purpose of perpetuating the species through space and time by delaying germination until specific environmental cues happen. Black oat, a temperate forage grass, is widely used for pasture and as a cover crop in minimum tillage systems in Southern Brazil. However, the largest portion of the seed

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36

Åberg, Alf. "Mutagena effekter av thiokarbanater." Licentiate thesis, Luleå tekniska universitet, 1985. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-17753.

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37

CARBONNAUX, FRENOVE CLAIRE. "Facteurs de croissance des fibroblastes (fgfs) et mutagenese : partie i: conformation des fgf acide et basique. partie ii: structure d'oligodesoxynucleotides contenant un site potentiellement mutagene." Paris 11, 1991. http://www.theses.fr/1991PA112003.

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Partie i: les facteurs de croissance des fibroblastes (fgfs) sont des proteines impliquees dans la croissance et la differenciation cellulaire. Nous avons etudie leur structure par dichroisme circulaire. Les resultats montrent que ces proteines sont constituees majoritairement de feuillets antiparalleles. Nous avons tente de poursuivre l'investigation par une etude rmn du fgf acide. Apres la preparation en grande quantite du fgf acide et la purification du fragment 68-140, nous avons recherche les conditions de solubilisation du materiel proteique. La tres faible solubilite du fgf acide et la

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38

Silveira, Gustavo da. "Caracterização da variabilidade gerada por hibridações artificiais e mutações em caracteres de importância agronômica em aveia preta." Universidade Federal de Pelotas, 2009. http://repositorio.ufpel.edu.br/handle/ri/1175.

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Made available in DSpace on 2014-08-20T13:25:42Z (GMT). No. of bitstreams: 1 Dissertacao_ Gustavo_da_Silveira.pdf: 344081 bytes, checksum: 9df6d3d1e8eb064ac8609c019c8f7914 (MD5) Previous issue date: 2009-02-16<br>Black oat (Avena strigosa Schreb.) is used as a forage or cover crop, green fertilizer, weed control (through competition or allelopatic effects) and soil pathogen reduction, playing an important role in crop rotation systems. Even with all these features, the high heterogeneity found in black oat fields indicates that very little progress has been made in breeding programs. N

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39

Schwimmer, Christine. "Contribution à l'étude des relations structure-fonction du transporteur mitochondrial de nucléotides adényliques : induction et caractérisation de mutants de S.cerevisiae résistants à l'acide bongkrékique." Bordeaux 2, 1999. http://www.theses.fr/1999BOR28648.

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40

Carrière, Christian. "Etude par mutagenèse du rôle de la polyprotéine Gag du virus de l'immunodéficience humaine (HIV-1) dans le processus d'assemblage des particules virales." Montpellier 1, 1995. http://www.theses.fr/1995MON1T005.

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41

Mennecier, Samuel. "Mutagenèse spontanée et mutagenèse induite chez la bactérie radiorésistante Deinococcus radiodurans." Paris 11, 2007. http://www.theses.fr/2007PA112120.

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Deinococcus radiodurans appartient à une famille de bactéries connue pour sa capacité exceptionnelle à surmonter l’effet létal des agents qui endommagent l’ADN tels que les radiations ionisantes, le rayonnement ultraviolet ou la dessiccation. Nous avons montré la présence chez D. Radiodurans d’un système de réparation des mésappariements (MMR) fonctionnel, impliqué tant dans la fidélité de la réplication que la fidélité de la recombinaison. L’inactivation du MMR n’est pas associée à une radio-sensibilisation, suggérant que ce système ne joue qu’un rôle mineur dans la reconstitution d’un génome

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42

Villani, Patrick. "Protocole d'étude des propriétés antimutagéniques de substances naturelles : application du test des micronoyaux dans les lymphocytes humains en culture." Aix-Marseille 2, 2000. http://theses.univ-amu.fr.lama.univ-amu.fr/2000AIX20667.pdf.

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43

Cuyubamba, Oscar R., William Pryor, Barbara S. Shane, and Giuseppe Squadrito. "¿Nos encontramos frente a una nueva clase de mutagenos?" Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/100645.

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El 1 ,3-dinitronaftaleno, previamente identificado en polvo ambiental, forma aductos covalentes con nucleótidos del DNA a temperatura ambiente fácilmente. La potencia mutagénica de un hidrocarburo aromático policíclico dinitrado (HAPDN), el 1, 3-dinitrofluoranteno, es prácticamente independiente de la cepa de Salmonella Typhimurium (TA98, TA98NR y TA98/1, 8DNP6) empleada en el Test de Ames. Este comportamiento poco usual sugiere que este HAPDN no requeriría de la activación metabólica vía la "nitroreductasa clásica" y/o de la acetilasa El hecho de que el 1, 3- dinitronaftaleno forma aductos co

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44

CIZEAU, JEANNICK. "Effet mutagene du cis-dichlorodiammineplatine(ii) chez drosophila melanogaster." Orléans, 1994. http://www.theses.fr/1994ORLE2014.

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Le cis-dichlorodiammineplatine(ii) ou cis-ddp est une drogue antitumorale largement utilisee dans certaines therapies anticancereuses. Il reagit avec l'adn en formant des pontages intrabrins et interbrins avec les n7 des purines. Le cis-ddp a egalement une activite mutagene qui a ete determinee chez des bacteries et des cellules d'eucaryotes en culture. Le cis-ddp induit principalement des mutations ponctuelles. Nous avons etudie cet effet sur un organisme entier: drosophila melanogaster. Deux genes, white et vermilion, situes sur le chromosome x ont ete choisis comme cible de mutagenese car l

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45

Zschenker, Oliver. "Zielgerichtete Mutagenese der lysosomalen Lipase." [S.l.] : [s.n.], 2001. http://www.sub.uni-hamburg.de/disse/429/Disse.pdf.

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46

Réveilleau, Valérie. "Tests de mutagénèse et de cytotoxicité applicables à l'eau." Paris 5, 1996. http://www.theses.fr/1996PA05P056.

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47

Goold, Richard David. "Influence of endogenous female sex-steroids on mutagen metabolism." Thesis, Rhodes University, 1985. http://hdl.handle.net/10962/d1004919.

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Cytochrome P-450, the terminal oxidase of the metabolic mono-oxygenase system, is thought to exist in multiple forms, which have differing substrate specificities, and are variably inducible by different enzyme inducers. Many mutagens, themselves unreactive, require metabolic activation by one or more of these cytochrome P-450-dependent microsomal enzymes for mutagenic activity. Such mutagens may be detected in the Salmonella mutagenicity test only by the incorporation of an hepatic microsomal (59) fraction into the assay (as a first approximation to in vivo metabolism). Induction of the micro

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48

Ehrenstein, Carmen. "Kontamination von Stadtgewässern mit mutagenen Substanzen." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=962783226.

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49

LOBO, NAPOLITANO RITA. "Mecanisme de la mutagenese frameshift induite." Université Louis Pasteur (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR13086.

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L'agent mutagene n-2-acetylaminofluorene forme un adduit sur la guanine qui constitue un bloc pour la replication de l'adn. Cette lesion va induire des mutations de type frameshift au sein de sequences de type (g)n et (gpc)n, la mutation correspondant a la deletion d'une unite de repetition. Afin de comprendre le(s) mecanisme(s) d'induction de ces mutations et le mecanisme de passage en face d'une lesion bloquante, nous avons construit des vecteurs contenant un adduit unique localise dans les differentes positions d'une sequence repetitive. Les resultats ont montre une frequence de mutation be

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Ratcliffe, Andrew J. "Synthesis of non-mutagenic anticancer drugs." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378598.

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