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Journal articles on the topic 'Mutagens'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Otsubo, Yuki, Shoji Matsumura, Naohiro Ikeda, and Osamu Morita. "Hawk-Seq™ differentiates between various mutations in Salmonella typhimurium TA100 strain caused by exposure to Ames test-positive mutagens." Mutagenesis 36, no. 3 (2021): 245–54. http://dx.doi.org/10.1093/mutage/geab006.

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Abstract A precise understanding of differences in genomic mutations according to the mutagenic mechanisms detected in mutagenicity data is required to evaluate the carcinogenicity of environmental mutagens. Recently, we developed a highly accurate genome sequencing method, ‘Hawk-Seq™’, that enables the detection of mutagen-induced genome-wide mutations. However, its applicability to detect various mutagens and identify differences in mutational profiles is not well understood. Thus, we evaluated DNA samples from Salmonella typhimurium TA100 exposed to 11 mutagens, including alkylating agents,

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2

Ang, Jocelyn, Lisa Yun Song, Sara D'Souza, et al. "Mutagen Synergy: Hypermutability Generated by Specific Pairs of Base Analogs." Journal of Bacteriology 198, no. 20 (2016): 2776–83. http://dx.doi.org/10.1128/jb.00391-16.

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ABSTRACTWe tested pairwise combinations of classical base analog mutagens inEscherichia colito study possible mutagen synergies. We examined the cytidine analogs zebularine (ZEB) and 5-azacytidine (5AZ), the adenine analog 2-aminopurine (2AP), and the uridine/thymidine analog 5-bromodeoxyuridine (5BrdU). We detected a striking synergy with the 2AP plus ZEB combination, resulting in hypermutability, a 35-fold increase in mutation frequency (to 53,000 × 10−8) in therpoBgene over that with either mutagen alone. A weak synergy was also detected with 2AP plus 5AZ and with 5BrdU plus ZEB. The pairin

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3

Nazarenko, M. M. "The influence of radio-mimetic chemical mutagen on the chromosomal complex of winter wheat cells." Regulatory Mechanisms in Biosystems 8, no. 2 (2017): 283–86. http://dx.doi.org/10.15421/021744.

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In this article we report the results of our investigation of cytogenetic parameters of changes in the chromosomal complex of new Ukrainian winter wheat varieties and some relationships between values of cytological indexes and different concentrations of DAB (1,4-bis-diazoacetyl butane). Analysis of chromosomal aberrations following mutagenic action of any kind of mutagen by the anaphase method is one of the most widely investigated and most precise methods which can be used to determine the fact of mutagenic action on plants and identify the nature of the mutagen. We combined in our investig

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4

Moreno, Débora Antunes Neto, Jaqueline de Cássia Proença-Assunção, Anna Paula Farias-de-França, Gabriel Ferreira Dos Santos, and Yoko Oshima-Franco. "The antimutagenic potential of Vanillin and Betulin based on the antimutagenicity of Resveratrol." CONTRIBUCIONES A LAS CIENCIAS SOCIALES 16, no. 8 (2023): 13224–43. http://dx.doi.org/10.55905/revconv.16n.8-255.

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Due to daily exposure to several compounds with mutagenic potential, it is extremely important to find antimutagenic agents, as here proposed to vanillin and betulin found in Dipteryx alata plant, evaluated by the Salmonella/microsome assay and resveratrol as reference. The antimutagenicity test employs mutagens that are incubated with a test substance to assess the inhibitory ability of the mutagenicity, interpreted as absent, moderate, or strong when the percentage of inhibition is lower than 25%; between 25 – 40% or greater than 40%, respectively. The assays were carried out in the absence

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5

Rajkumari, Jinu Devi. "Efficiency and effectiveness of physical and chemical mutagens in Trigonella foenum graecum L." NBU Journal of Plant Sciences 6, no. 1 (2012): 87–88. http://dx.doi.org/10.55734/nbujps.2012.v06i01.013.

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Trigonella foemum graecum L was utilized to study the Chlorophyll mutations, mutagenic efficiency and effectiveness by physical mutagen gamma rays and chemical mutagen EMS. The frequency of chlorophyll mutation in M1 & M2 generation were more in gamma treated plants but the mutation spectra and mutagenic efficiency of EMS was higher than gamma. The most efficient mutagens were 0. 02% EMS, 0.06% EMS and 3KR gamma radiation to induce mutation in T. foenum graceum L.

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6

Langová, M., Z. Polívková, P. Šmerák, J. Bártová, and I. Bárta. "Antimutagenic effect of resveratrol." Czech Journal of Food Sciences 23, No. 5 (2011): 202–8. http://dx.doi.org/10.17221/3392-cjfs.

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Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutagenic activity of three mutagens, i.e. aflatoxin B<sub>1</sub> (AFB<sub>1</sub>), 2-amino-3-methylimidazo[4,5-f]qui-noline (IQ) and N-nitroso-N-methylurea (MNU) using the Ames and the micronucleus tests. In the Ames test, we proved a significant antimutagenic activity only against the indirect mutagens AFB<sub&g

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7

Mullainathan, L., and S. Umavathi. "Induced Mutagenesis in Cicer arietinum." International Letters of Natural Sciences 12 (March 2014): 1–4. http://dx.doi.org/10.18052/www.scipress.com/ilns.12.1.

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The traditional varieties of chick pea have low potentiality and restricted variability with respect to economic characters. Broadening the genetic base for crop improvement can be quickly achieved through induced mutagenesis. The present study was undertaken in order to comparing the effectiveness and efficiency of mutagens on Cicer arietinum. In this regard, Co – 4 variety of chick pea was subjected to different dose/concentration of Gamma rays (20, 30, 40, 50 and 60 kR) and Ethyl Methane Sulphonate (10, 20, 30, 40 and 50 mM) for inducing mutation. Mutagenic effectiveness and efficiency was

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8

Mullainathan, L., and S. Umavathi. "Induced Mutagenesis in <i>Cicer arietinum</i>." International Letters of Natural Sciences 12 (March 14, 2014): 1–4. http://dx.doi.org/10.56431/p-cp3s6r.

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The traditional varieties of chick pea have low potentiality and restricted variability with respect to economic characters. Broadening the genetic base for crop improvement can be quickly achieved through induced mutagenesis. The present study was undertaken in order to comparing the effectiveness and efficiency of mutagens on Cicer arietinum. In this regard, Co – 4 variety of chick pea was subjected to different dose/concentration of Gamma rays (20, 30, 40, 50 and 60 kR) and Ethyl Methane Sulphonate (10, 20, 30, 40 and 50 mM) for inducing mutation. Mutagenic effectiveness and efficiency was

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9

Nagarajan*, Prabhu, Vigneshwari Ramakrishnan Sundaramoorthy, and Joseph Pushpa Innocent Danialas. "Antimutagenic effects of compounds obtained from Eclipta alba linn. against strains of Salmonella typhimurium." International Journal of Bioassays 1, no. 10 (2012): 102. http://dx.doi.org/10.21746/ijbio.2012.10.009.

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In this experimental study, antimutagenic activity of compounds obtained from Eclipta alba Linn was screened by using Ames assay for detecting direct mutagenic activity and those requiring the metabolic activation. The crude compound extracted from Eclipta alba was considered as antimutagen and analyzed in this experiment. Two strains of Salmonella typhimurium, TA163 and TA96 were used to analyze the test. These two strains are confirmed as histidine requiring mutant strains. When the mutagen is added to the culture, the strain is mutated back, thereby loosing the histidine dependence for its

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10

Mangroliya, R. M., Sudha Patil, P. M. Mangroliya, and Kinjal Bambhaniya. "Impact of Physical and Chemical Mutagens on Vegetative Growth of China Aster [Callistephus chinensis (l.) Nees] cv. Phule Ganesh Pink." International Journal of Plant & Soil Science 36, no. 12 (2024): 651–59. https://doi.org/10.9734/ijpss/2024/v36i125240.

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The present study was carried out in two different experiments of mutation during September, 2021 to March, 2022 at Floriculture Research Farm, ASPEE College of Horticulture, Navsari Agricultural University, Navsari, Gujarat. The experiment was conducted for two generations and laid out in Randomized Block Design (RBD) with three and five replications. During 2021-22, seedlings of China aster var. Phule Ganesh Pink were treated with different doses of various mutagens which included four treatments of gamma rays (0.25 kR, 0.50 kR, 0.75 kR and 1.00 kR) and another four treatments of chemical mu

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11

KRONE, CHERYL A., and WAYNE T. IWAOKA. "Commercial Food Processing Operations and Mutagen Formation." Journal of Food Protection 50, no. 2 (1987): 167–74. http://dx.doi.org/10.4315/0362-028x-50.2.167.

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Thermally-induced bacterial mutagens are formed when foods are processed by some commercial food preservation techniques. The processes which involve longer times and higher temperatures are most likely to produce mutagens (e.g., canning and evaporative concentration). Pasteurization and spray drying processes possess a low potential for creation of mutagens. The types of food products with the greatest tendency to contain mutagens following heat treatments are muscle foods such as canned meats and fish. Canned beef broth, chili, hash, roast beef, pink and red salmon, and mackerel contain subs

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12

Šmerák, P., H. Šestáková, Z. Polívková, et al. "Antimutagenic effect of ellagic acid and its effect on the immune response in mice." Czech Journal of Food Sciences 20, No. 5 (2011): 181–91. http://dx.doi.org/10.17221/3530-cjfs.

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Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid on the genotoxicity of three mutagens: amino-methylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). Ellagic acid is a naturally occurring phenolic compound which is found in a variety of soft fruits and vegetables. The effect of this compound on the immunosuppressive activity of mutagens was followed in vivo by the chemiluminescence test. In the Ames assay, ellagic acid at concentrations of 300 and 30 &mu;g/plate demonstrably in

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13

G, Parthasarathi, Sugitha Thankappan, M. Arumugam Pillai, R. Kannan, S. Merina Prem Kumari, and Asish K. Binodh. "INDUCED GENETIC VARIABILITY IN SESAME (Sesamum indicum L): A COMPARATIVE STUDY ON THE MUTAGENIC EFFECTS OF RADIATION AND EMS IN SEED GERMINATION, POLLEN VIABILITY AND CHLOROPHYLL MUTANTS." Journal of Experimental Biology and Agricultural Sciences 8, no. 6 (2020): 774–88. http://dx.doi.org/10.18006/2020.8(6).774.788.

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The present study envisaged the effects of two mutagens, gamma rays and EMS on the phenotypes of two sesame varieties viz., TMV7 and SVPR1. A known quantity of dry, uniform, and healthy seeds of TMV7 and SVPR 1 were irradiated using Co60 (Cobalt 60) with different doses (250, 300, 350, 400, 450 Gy) of gamma rays. For chemical mutagenesis, different concentrations of EMS @ 0.20%, 0.40% and 0.60% was used and treated for 8 h. The dose-response curve of the probit analysis showed that the optimal lethal dose for SVPR1was lower than TMV7. The expected LD50 values of gamma radiation for TMV 7 and S

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14

Reddy, M. Sridhar, and Osman Basha Pinjari. "Mutagenesis Approaches in Plants and their Applications." Asian Journal of Agriculture and Allied Sciences 6, no. 1 (2023): 20–29. http://dx.doi.org/10.56557/ajaas/2023/v6i135.

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Mutagenesis refers to the process of generation of mutations in DNA molecules, including chromosomal rearrangements and alterations in DNA sequence. The incidence of natural or spontaneous mutation frequency in nature is very low, and it is not sufficient for plant breeding programs to develop new varieties. Mutants were also used for gene function discovery which controls the particular phenotype. Genetic diversity was induced in plants on a good scale through induced mutagenesis programmes, and this helped to improve crops all over the world. Significant efforts have been made to develop ind

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15

Uchinomiya, Kouki, and Masanori Tomita. "A mathematical model for cancer risk and accumulation of mutations caused by replication errors and external factors." PLOS ONE 18, no. 6 (2023): e0286499. http://dx.doi.org/10.1371/journal.pone.0286499.

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Replication errors influence mutations, and thus, lifetime cancer risk can be explained by the number of stem-cell divisions. Additionally, mutagens also affect cancer risk, for instance, high-dose radiation exposure increases lifetime cancer risk. However, the influence of low-dose radiation exposure is still unclear because this influence, if any, is very slight. We can assess the minimal influence of the mutagen by virtually comparing the states with and without mutagen using a mathematical model. Here, we constructed a mathematical model to assess the influence of replication errors and mu

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16

Cassand, Pierrette, Hasnaa Abdelali, Christine Bouley, Gerard Denariaz, and Jean F. Narbonne. "Inhibitory effect of dairy products on the mutagenicities of chemicals and dietary mutagens." Journal of Dairy Research 61, no. 4 (1994): 545–52. http://dx.doi.org/10.1017/s0022029900028478.

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SummaryThe antimutagenic effects of uninoculated milk and milks cultured with Bifidobacterium or Lactobacillus strains towards the mutagenicity induced by two direct mutagens, 4-nitroquinoline N-oxide and 2-nitrofluorene, and three dietary indirect mutagens, aflatoxin B1, benzo(a)pyrene and quercetin, were investigated using the in vitro Salmonella typhimurium test. Each cultured milk sample and control milk had a significant antimutagenic effect, to an extent varying with the mutagen used. Uninoculated milk had a greater inhibitory effect than cultured milks towards dietary indirect mutagens.

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17

Wani, Mohammad Rafiq. "Characterization of chlorophyll deficient mutants in mungbean (Vigna radiata (L.) Wilczek)." Bangladesh Journal of Botany 49, no. 4 (2020): 1013–19. http://dx.doi.org/10.3329/bjb.v49i4.52532.

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A wide spectrum of chlorophyll mutants was obtained in M2 generation following mutagenesis with MMS, HZ and SA. All these chlorophyll deficient mutants were lethal except maculata, viridis and virescent. MMS treatments induced the highest frequency of chlorophyll mutations followed by HZ and SA. The frequency of chlorophyll mutations was dose dependent and increased with increasing concentrations of all the three mutagens utilized. Chlorina followed by xantha outnumbered the other types of chlorophyll mutants with all the three mutagens. Based on effectiveness, the order of mutagens was HZ &gt

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18

Khamidulina, Kh Kh, D. N. Rabikova, E. V. Tarasova, T. A. Sinitskaya, I. V. Zamkova, and A. K. Nazarenko. "Modern approaches to the assessment and classification of the hazard posed by substances with mutagenic effects." Health Risk Analysis, no. 4 (December 2024): 4–13. https://doi.org/10.21668/health.risk/2024.4.01.eng.

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There are no lists of chemicals with mutagenic effects in the Russian Federation and in the states of the Eurasian Economic Union. Therefore, within the framework of the program ‘Development of integrated approaches to testing, assessing hazards and risk of exposure to chemicals for human health and improvement of the evidence base of toxicological research results’ (deadlines: 2024–2025), the Russian Register of Potentially Hazardous Chemical and Biological Substances – Branch of F.F. Erisman Federal Scientific Center of Hygiene of the Rospotrebnadzor has completed several work tasks concerni

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Khamidulina, Kh Kh, D. N. Rabikova, E. V. Tarasova, T. A. Sinitskaya, I. V. Zamkova, and A. K. Nazarenko. "Modern approaches to the assessment and classification of the hazard posed by substances with mutagenic effects." Health Risk Analysis, no. 4 (December 2024): 4–13. https://doi.org/10.21668/health.risk/2024.4.01.

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There are no lists of chemicals with mutagenic effects in the Russian Federation and in the states of the Eurasian Economic Union. Therefore, within the framework of the program ‘Development of integrated approaches to testing, assessing hazards and risk of exposure to chemicals for human health and improvement of the evidence base of toxicological research results’ (deadlines: 2024–2025), the Russian Register of Potentially Hazardous Chemical and Biological Substances – Branch of F.F. Erisman Federal Scientific Center of Hygiene of the Rospotrebnadzor has completed several work tasks concerni

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20

Polívková, Z., M. Langová, P. Šmerák, B. Bártová, and I. Bárta. "Antimutagenic effect of genistein." Czech Journal of Food Sciences 24, No. 3 (2011): 119–26. http://dx.doi.org/10.17221/3306-cjfs.

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A great variety of health benefits including the protection against breast and prostate cancers has been attributed to the soya consumption, because of the presence of soy beans isoflavones, genistein, and others. We investigated the antigenotoxic effect of genistein on the genotoxicity of three mutagens and carcinogens &ndash; aflatoxine B<sub>1</sub> (AFB<sub>1</sub>), 2-amino-3-methylimidazo [4,5-f]quinoline (IQ), and N-nitroso-N-methylurea (MNU), using the Ames bacterial mutagenicity test and the micronucleus test. In the Ames test on Salmonella typhimurium, a s

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C. Sarada. "Determination of mutagenic effectiveness and efficiency of gamma rays and EMS in Coriander." World Journal of Biological and Pharmaceutical Research 7, no. 2 (2024): 001–6. http://dx.doi.org/10.53346/wjbpr.2024.7.2.0034.

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Coriander is a dual purpose vegetable used as leaf as well as a spice, along with medicinal properties. Owing to its compound umbel and difficulty in crossing programme, mutation breeding is the available source to create variability. Mutagenesis is a well-recognized tool to expand genetic variability. The present investigation involves mutagenesis in coriander cv. Sindhu with physical (gamma rays) and chemical mutagens (EMS) and their combinations. The mutation frequency, mutagenic effectiveness and mutagenic efficiency were calculated for the gamma rays, EMS and their combination doses. In g

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Türkoğlu, Aras, Kamil Haliloğlu, Metin Tosun, et al. "Ethyl Methanesulfonate (EMS) Mutagen Toxicity-Induced DNA Damage, Cytosine Methylation Alteration, and iPBS-Retrotransposon Polymorphisms in Wheat (Triticum aestivum L.)." Agronomy 13, no. 7 (2023): 1767. http://dx.doi.org/10.3390/agronomy13071767.

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The use of mutagens in plant breeding is used to create new germplasm, increase agricultural yield, quality, and resistance to diseases and pests. Mutagens are physical or chemical factors that can alter the DNA or RNA structure of an organism, causing mutations above the expected level. One of the most common and potent chemical mutagens is EMS (ethyl-methane sulfonate), which produces point mutations in plants, but to a lesser degree can also cause the loss or deletion of a chromosomal region. This study used inter-primer binding site (iPBS) and coupled restriction enzyme digestion inter-pri

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23

Nakamuro, K., H. Ueno, and Y. Sayato. "Evaluation of Mutagenicity of Municipal River Water Concentrated Using XAD Resin Column Method." Water Science and Technology 25, no. 11 (1992): 293–99. http://dx.doi.org/10.2166/wst.1992.0305.

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The physico-chemical and mutagenic properties of organic concentrates from the Yodo river water were investigated using XAD resin column method with XAD-2, XAD-4 and XAD-8 under various adsorptive and desorptive conditions. XAD resin concentrates showed to be directly and indirectly frameshift mutagenic. Organic mutagens in the Yodo river water were almost absorbed to XAD-2 resin and then desorbed effectively with CH2Cl2. The physico-chemical properties of these concentrates were acidic and hydrophobic. Additionally organic mutagens which possess basic and hydrophilic properties may contribute

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Kishida, M., T. Kumabe, H. Takanashi, et al. "Chlorination by-products of fenitrothion." Water Science and Technology 62, no. 1 (2010): 85–91. http://dx.doi.org/10.2166/wst.2010.264.

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The mutagens produced through chemical reaction between chlorine and the insecticide fenitrothion were studied by using a quadrupole GC-MS. The mutagenicity and the mutagen formation potential (MFP) of the identified by-products were evaluated by the Ames assay (preincubation method) using Salmonella typhimurium TA100 without exogenous activation by S9 mix (TA100-S9). Before conducting GC/MS analyses, six compounds were presumed to be produced in chlorinated fenitrothion. These compounds were confirmed to be produced by the GC/MS analyses, but none of them were mutagenic. One of the chlorinati

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Hovhannisyan, Galina, Tigran Harutyunyan, Rouben Aroutiounian, and Thomas Liehr. "DNA Copy Number Variations as Markers of Mutagenic Impact." International Journal of Molecular Sciences 20, no. 19 (2019): 4723. http://dx.doi.org/10.3390/ijms20194723.

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DNA copy number variation (CNV) occurs due to deletion or duplication of DNA segments resulting in a different number of copies of a specific DNA-stretch on homologous chromosomes. Implications of CNVs in evolution and development of different diseases have been demonstrated although contribution of environmental factors, such as mutagens, in the origin of CNVs, is poorly understood. In this review, we summarize current knowledge about mutagen-induced CNVs in human, animal and plant cells. Differences in CNV frequencies induced by radiation and chemical mutagens, distribution of CNVs in the ge

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Degtyareva, I. A., E. V. Babynin, and E. A. Prishchepenko. "Nanostructured minerals developed to be used as fertilizers: biosafety evaluation." Proceedings of Universities. Applied Chemistry and Biotechnology 12, no. 3 (2022): 438–46. http://dx.doi.org/10.21285/2227-2925-2022-12-3-438-446.

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Natural zeolites are effectively used as fertilizers, substrates, and pesticide carriers, as well as sorbents in the remediation of contaminated soils. Since nanostructured minerals exhibit unique physicochemical properties, they must be tested for toxicity and genotoxicity prior to their use in practice. The mutagenic and antimutagenic properties of a nanostructured water-zeolite suspension were first tested using two bacterial test systems: Ames test and SOS-lux test. According to the obtained data, the nanostructured water-zeolite suspension exhibits no mutagenic activity within the analyze

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Journal, Baghdad Science. "Developing of Bacterial Mutagenic Assay System for Detection of Environmental and Food MutagensV – Using Anticancer Drug Cyclophosphamide." Baghdad Science Journal 5, no. 4 (2008): 500–512. http://dx.doi.org/10.21123/bsj.5.4.500-512.

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G-system composed of three isolates G3 ( Bacillus),G12 ( Arthrobacter )and G27 ( Brevibacterium) was used to detect the mutagenicity of the anticancer drug, cyclophosphamide (CP) under conditions similar to that used for standard mutagen, Nitrosoguanidine (NTG). The CP effected the survival fraction of isolates after treatment for 15 mins using gradual increasing concentrations, but at less extent comparing to NTG. The mutagenic effect of CP was at higher level than that of NTG when using streptomycin as a genetic marker, but the situation was reversed when using rifampicin resistant as a repo

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Al-Khafaji, Zahra M., Elham A. Kalaf, and Gaith L. Al-Azawi. "Developing of Bacterial Mutagenic Assay System for Detection of Environmental and Food MutagensV – Using Anticancer Drug Cyclophosphamide." Baghdad Science Journal 5, no. 4 (2008): 500–512. http://dx.doi.org/10.21123/bsj.2008.5.4.500-512.

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G-system composed of three isolates G3 ( Bacillus),G12 ( Arthrobacter )and G27 ( Brevibacterium) was used to detect the mutagenicity of the anticancer drug, cyclophosphamide (CP) under conditions similar to that used for standard mutagen, Nitrosoguanidine (NTG). The CP effected the survival fraction of isolates after treatment for 15 mins using gradual increasing concentrations, but at less extent comparing to NTG. The mutagenic effect of CP was at higher level than that of NTG when using streptomycin as a genetic marker, but the situation was reversed when using rifampicin resistant as a repo

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Kumari, Priyanka, Manigopa Chakraborty та Milan Kumar Chakravarty. "Effect of Different Doses of γ-rays (50 Gy, 100 Gy, 150 Gy, 200 Gy& 400 Gy) in M3 Generation of Soybean (Glycine max (L.) Merril) Genotypes". International Journal of Current Microbiology and Applied Sciences 13, № 6 (2024): 246–51. http://dx.doi.org/10.20546/ijcmas.2024.1306.026.

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Soybean genetic variation improvement is important for the development of superior cultivars. One of the greatest challenges in mutation breeding is random (uncontrolled) nature of induced mutagenesis. Large population requirement for desired mutant selection brings intensive labor. Choice of appropriate mutagen is one of the deciding factors on succession of the mutation breeding program. Physical, chemical, or biological agents are viable alternatives. Among physical mutagens ionizing radiation sources, particle (electrons, protons, neutrons, alpha and beta particles) or electromagnetic (X-r

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Hubanova, Yu S. "Evaluation of informativeness of mutation groups of Nigella damascena L. M2 generation." Plant varieties studying and protection 19, no. 1 (2023): 15–23. http://dx.doi.org/10.21498/2518-1017.19.1.2023.277767.

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Purpose. To carry out a mathematical and statistical evaluation of the mutagenesis data of the M2 generation of Nigella damascena varieties ‘Berehynia’ and ‘Charivnytsia’ in order to identify relationships between groups of mutations and mathematical justification of their use in the process of further analysis and selection of hereditary changes of mutant plants. Methods. Seeds of the varieties ‘Berehynia’ and ‘Charivnytsia’ were treated with chemical mutagens. The mutations identified by visual observation of the plants at different stages of their growth and development were divided into ei

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Gangwar, Rohit, Prajwal Chaudhary, Dipak Kumar, et al. "A Comprehensive Review on Application of Conventional and Mutation Approaches in Genetic Improvement of Ornamental Crops." Journal of Advances in Biology & Biotechnology 28, no. 1 (2025): 390–407. https://doi.org/10.9734/jabb/2025/v28i11893.

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Effective mutagenic treatment techniques for different species are of tremendous interest due to the exciting potential of mutation breeding in ornamental plants. The present article addresses the mutagenesis treatments of numerous ornamental genera, the benefits and drawbacks of different methods, and the potential for enhancing the related protocols. There are several techniques for non-targeted mutagenesis, from chemical treatment with alkylating chemicals to dose-dependent exposure to X-rays, gamma rays, neutron or heavy ion beams. All of these have been shown to be efficient mutagens in a

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Ostojic, Bojana, and Dragana Djordjevic. "The role of molecular properties of mononitrofluoranthenes to their mutagenic activity: Insight from ab initio and DFT calculations." Journal of the Serbian Chemical Society 84, no. 8 (2019): 861–76. http://dx.doi.org/10.2298/jsc190509045o.

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The molecular properties of the environmental mutagens nitrofluoranthenes (NFs; 1-, 2-, 3-, 7- and 8-NF), such as (hyper)polarizability, dipole moment, molecular electrostatic potential (MEP), spectroscopic characteristics, magnetic index (NICS) and others, obtained by means of ab initio (MP2) and density functional theory (DFT) approaches have been correlated with the observed mutagenic activities. A very good linear correlation (Rav = 0.99) between average polarizability (<?>) and experimental mutagenic activities of NFs in different Salmonella typhimurium strains from two independent

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Kryshyn, R., and M. Nazarenko. "Cytogenetic effect of highly active ecogenetic factors on winter wheat." Agrology 8, no. 1 (2025): 40–47. https://doi.org/10.32819/202506.

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The study was aimed at exploring the potential of ethylmethanesulfonate (EMS) as a mutagen by examining its ability to induce chromosomal aberrations, its interaction with different genotypes, and the characteristics of genotype-mutagenic interactions. It also focused on evaluating the feasibility of using EMS in future applications, including its predictive value when tested at the cellular level for determining its mutation-inducing capacity at the plant level. Seeds of winter wheat two varieties (Spivanka and Altigo) were treated with ethylmethansulfonate (EMS) at concentrations of 0.025%,

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Ariraman, M., T. Bharathi, and D. Dhanavel. "Studies on the effects of mutagens on cytotoxicity behaviour in Pigeon pea (Cajanus cajan (L.) Millsp) Var.CO-7." Journal of Applied and Advanced Research 1, no. 1 (2016): 25. http://dx.doi.org/10.21839/jaar.2016.v1i1.10.

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The cytological studies provide more information regarding the response of a genotype to the particular mutagen and also provide chances to select desirable characters. The seeds of pigeon pea were subjected to different doses and concentrations of gamma rays and ethyl methane sulphonate (EMS). The effects of different mutagenic treatments on mitosis chromosomal behavior have been studied in both the mutagens. Different types of mitotic aberrations like stickiness, precocious movement, bridge, clumping of chromosome and laggards, etc., were observed in all the treatments. However, the gamma ra

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Wolz, Lucie, Günter Krause, and Gerhard Scherer. "The Comet Assay with MCL-5 Cells as an Indicator of Genotoxic Treatment with Chemicals and Cigarette Smoke Condensate." Alternatives to Laboratory Animals 30, no. 3 (2002): 331–39. http://dx.doi.org/10.1177/026119290203000311.

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The metabolically competent human lymphoblastoid cell line MCL-5 was treated with a panel of mutagens to assess the induction of DNA damage. Treatment effects were observed by monitoring cell proliferation and by single-cell gel electrophoresis (SCGE). The direct-acting mutagens benzo[ a]pyrene-7,8-diol 9, 10-epoxide (BPDE) and 1-methyl-3-nitro-1-nitrosoguanidine (MNNG), as well as pro-mutagens requiring metabolic activation, i.e. benzo[a]pyrene (BaP), 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyri-dine (PhIP), 4- N-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and cigarette-smoke condensa

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Bhat, Navya, M. R. Dinesh, H. S. Vageeshbabu, G. C. Acharya, S. N. Dash, and S. C. Swain. "Determination of mutagenic sensitivity and its manifestations on papaya (Carica papaya L.) cv. Arka Prabhath." Journal of Horticultural Sciences 18, no. 1 (2023): 27–34. http://dx.doi.org/10.24154/jhs.v18i1.2143.

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Papaya is an important fruit crop of the family Caricaceae which needs the improvement in terms of virus resistance and shelf life with dwarf stature. Mutation breeding technique has been considered as an efficient tool adopted by plant breeders to create variability in papaya. The mutation frequency and population structure of the mutants directly depend upon the type of mutagen and the time of exposure. Irrespective of the used mutagens, the ultimate induced mutations are random and therefore determination of mutagenic sensitivity is important pre-requisite. Based on this, investigation on t

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Kim, Eun J., Anna M. Matuszek, Bo Yu, and Jóhannes Reynisson. "Theoretical Investigations into the Role of Aryl Nitrenium Ions' Stability on Their Mutagenic Potential." Australian Journal of Chemistry 64, no. 7 (2011): 910. http://dx.doi.org/10.1071/ch11043.

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By using Mulliken and Natural Bond Orbital (NBO) methods based on the density functional theory (DFT), partial charges of exocyclic nitrogen atoms were calculated for nitrenium ions formed from 201 known drugs and 50 Ames positive (mutagenic) compounds containing aryl amine and nitro moieties. The statistical difference of the partial charges was analysed based on the hypothesis that the mutagens have a more negative charge on their exocyclic nitrogen atom resulting in stable nitrenium ions, and thus a longer lifetime to react selectively with DNA; whereas known drugs are not in general mutage

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S. Sofia, D. M. Reddy, K. H. P. Reddy, P. Latha, B. Ravindra Reddy, and M. Sreevalli Devi. "Effectiveness and efficiency of physical and chemical mutagens in inducing viable mutations in M2 generation of mungbean (Vigna radiata (L.) Wilczek)." Ecology, Environment and Conservation 30, no. 02 (2024): 743–47. http://dx.doi.org/10.53550/eec.2024.v30i02.054.

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Mutagenic effectiveness and efficiency of gamma rays, ethyl methane sulphonate (EMS) and sodium azide (SA) treatments were assessed in two mungbean varieties viz., WGG-42 and LGG-460 in M2 generation. Mutagenic effectiveness and efficiency were calculated in relation to biological damage in M1 and viable mutations in M2 generation. In the present study, viable mutation frequency increased with an increase in dose/concentration of mutagens, EMS showed the highest frequency of viable mutations than gamma rays and SA treatments in both the genotypes. The highest frequency of viable mutations were

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Rajendran, Rajam, and Yoshiyuki Ohta. "Binding activity of Natto (a fermented food) and Bacillus natto isolates to mutagenic-carcinogenic heterocyclic amines." Canadian Journal of Microbiology 47, no. 10 (2001): 935–42. http://dx.doi.org/10.1139/w01-094.

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The fermented food, whole meal Natto, viscous polymeric material from Natto, Natto bean, cooked soya bean, and 28 bacterial isolates from Natto were studied for their binding capacity to foodborne mutagenic-carcinogenic heterocyclic amines. The mutagenic heterocyclic amines used were Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole); Trp-P-2 (3-amino-1-methyl-5H-pyrido(4,3-b)indole); Glu-P-1 (2-amino-6-methyldipyrido(1,2-a:3'2'-d)imidazole); PhIP (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine); IQ (2-amino-3-methylimidazo(4,5-f)quinoline); MeIQ (2-amino-3,4-dimethylimidazo(4,5-f)quinoxal

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Bara, Adrianna Wiktoria, Agnieszka Braszewska, and Jolanta Kwasniewska. "DNA Methylation—An Epigenetic Mark in Mutagen-Treated Brachypodium distachyon Cells." Plants 10, no. 7 (2021): 1408. http://dx.doi.org/10.3390/plants10071408.

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The chromatin structure is significantly influenced by some epigenetic modifications including DNA methylation. The nuclear organization plays an essential role in the cell response to external stresses including mutagens. We present an analysis of the correlation between epigenetic modifications and the instability of the Brachypodium distachyon genome, which are observed as micronuclei, following maleic hydrazide (MH) and nitroso-N-methylurea (MNU) treatments. We compared the level of DNA methylation in the control (untreated) and mutagen-treated B. distachyon nuclei. An immunostaining metho

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Abdul-Hafeez, Essam Y., Nazira S. Karamova, and Olga N. Ilinskaya. "Evaluation of mutagenic and antimutagenic potential of stem bark aqueous extracts of eight trees by the bacterial reverse mutation assay." Ecological genetics 16, no. 3 (2018): 55–61. http://dx.doi.org/10.17816/ecogen16355-61.

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Stem bark aqueous extracts of eight woody plants Brachychiton populneus, Ceiba pentandra, Bombax malabaricum, Chorisia speciosa, Albizia lebbeck, Bauhinia variegata, Kigelia africana and Pinus halepensis were tested for their mutagenic and antimutagenic potential in the Ames test with Salmonella typhimurium strains TA98 and TA100. The aqueous extracts were neither toxic nor mutagenic in S. typhimurium tester strains. All of the tested extracts showed detectable antimutagenic effect towards the direct acting mutagens 2-nitrofluorene (2-NF) in TA98 as well as sodium azide in TA100. The extract f

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Totušek, J., D. Lefnerová, M. Kyseláková, et al. "Antimutagenic activity of raw materials and by-products by production of grape wines." Czech Journal of Food Sciences 26, Special Issue (2009): S55—S59. http://dx.doi.org/10.17221/247/2008-cjfs.

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The inhibition of mutagenicity was assessed by Ames test by bacterial strains <i>Salmonella typhimurium</i> TA98 and TA100 using two mutagens and methanolic extracts of healthy fresh berries of blue grapevine varieties – St. Laurent, Portugal, André and white varieties – Chardonnay, Welschriesling, Pinot Gris and berries infected with <i>Botrytis cinerea</i> fungus. As model mutagens, two compounds whose presence in food is real, 2-amino-3-methyl-3H-imidazo-(4.5-f-)-quinoline (IQ), arising from certain heat treatments of meat and acting as indirect mutagen after metabol

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Kaur, Rajbir, Upendra Sharma, Bikram Singh, and Saroj Arora. "Antimutagenic and Antioxidant Characteristics of Chukrasia tabularis A Juss Extracts." International Journal of Toxicology 30, no. 1 (2010): 21–34. http://dx.doi.org/10.1177/1091581810385362.

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The current study aims to evaluate the antioxidative and antimutagenic activities of methanol extract and different fractions of Chukrasia tabularis leaves. The antioxidative potential was evaluated using 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation and superoxide anion radical-scavenging assay. The antimutagenic potential was evaluated against direct-acting mutagens, 4-nitro- o-phenylenediamine and sodium azide; and S9-dependent mutagen, 2-aminofluorene in TA98 and TA100 strains of Salmonella typhimurium using Ames assay. It has been found that methanol extract and its

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Jongen, W. M. F., and F. O. Dorgelo. "Naturally occurring carcinogens and modulating factors in food of plant origin." Netherlands Journal of Agricultural Science 34, no. 3 (1986): 395–404. http://dx.doi.org/10.18174/njas.v34i3.16793.

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The current state of knowledge concerning the process of carcinogenesis, including the role of initiators and promoters is discussed, and foods of plant origin which contain naturally occurring carcinogens and mutagens are highlighted. Carcinogens and promoters, anticarcinogens and endogenous formation of mutagens and carcinogens are also covered. The mutagenic activity in some foods of plant origin is tabulated and the role of plant breeding in introducing or deleting the carcinogenic or anticarcinogenic properties in these foods is discussed. It is suggested that future research will focus o

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Yasmin, K., and D. Arulbalachandran. "Gamma irradiation effects on crop plants." Research Journal of Biotechnology 17, no. 8 (2022): 126–35. http://dx.doi.org/10.25303/1708rjbt1260135.

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Mutation breeding has played a crucial role to enhance the world food security, hence new crop varieties induced by the utilization of various mutagens have contributed to the significant enhancement of crop production. In the current scenario, physical mutagen played a vital role to induce more new varieties with desirable traits in crop breeding. Among the physical mutagens, gamma irradiation act as more effective tool to induce new traits in various crop plants. Hence, the present critical review focused to determine the potential effects of gamma irradiation on plant growth, biological and

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Jiang, Li, and Bruce L. Dunn. "Ethyl Methanesulfonate and Caffeine Mutagenetic Treatment to Four Ornamental Silene Species." Journal of Environmental Horticulture 34, no. 4 (2016): 95–100. http://dx.doi.org/10.24266/0738-2898-34.4.95.

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Mutagenesis breeding for horticultural crops is valuable not only for creating new cultivars, but also expanding the genetic pool for hybridization. Four Silene species were subjected to ethyl methanesulfonate (EMS) and/or caffeine mutagenesis to obtain valuable ornamental traits and to test the effects of different mutagens and combinations. Species responded differently to the mutagens. Generally, caffeine plus EMS treatments had a greater effect on mutation rate than either treatment applied alone. Caffeine alone was found to enhance seed vigor of S. floscuculi. Caffeine as a plant mutagen

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Kolar, Firdose R., Swaroopa R. Ghatge, Mansingraj S. Nimbalkar, and Ghansham B. Dixit. "Mutational Changes In Delphinium malabaricum (Huth.) Munz.: A Potential Ornamental Plant." Journal of Horticultural Research 23, no. 2 (2015): 5–15. http://dx.doi.org/10.2478/johr-2015-0012.

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AbstractMutation breeding is an established method used for crop improvement and has played a major role in the development of many new flower color/shape mutant cultivars in ornamentals. The present study is aimed at inducing mutations inDelphinium malabaricumusing chemical mutagens ethyl methane sulfonate (EMS), sodium azide (SA) and physical mutagen (gamma rays). It was observed thatD. malabaricummanifested specific reactions to the treatments with EMS, SA and gamma rays. Identification and selection of mutations were carried out in the second generation (M2). A variety of chlorophyll defic

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Awasthi, Sanjay. "Haploinsufficiency Interactions of RALBP1 and TP53 in Carcinogenesis." Cancers 13, no. 2 (2021): 255. http://dx.doi.org/10.3390/cancers13020255.

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Mutagenic environmental chemical or radiant stresses directly damage DNA and amplify the formation of potent endogenous mutagens from lipid peroxidation, leading to cancers that cause millions of deaths and impose enormous financial and social burdens [...]

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Acésio, Nathália Oliveira, Pollyanna Francielli de Oliveira, Daiane Fernanda Pereira Mastrocola, et al. "Modulatory Effect of Betulinic Acid on the Genotoxicity Induced by Different Mutagens in V79 Cells." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/8942730.

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Betulinic acid (BA) is a pentacyclic triterpene that can be isolated from many medicinal plants around the world. The aim of this study was to evaluate the genotoxic potential of BA and its effect on the genotoxicity induced by different mutagens in V79 cells using the cytokinesis-block micronucleus assay. Different BA concentrations were combined with methyl methanesulfonate (MMS), doxorubicin (DXR), camptothecin (CPT), and etoposide (VP-16). The frequencies of micronuclei in cultures treated with different BA concentrations did not differ from those of the negative control. Treatment with BA

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Nazarenko, M. M. "Rates and spectra of chromosome aberrations in winter wheat cells after dimethylsulfate action." Ukrainian Journal of Ecology 7, no. 3 (2017): 128–33. http://dx.doi.org/10.15421/2017_60.

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In the article we report about our investigation of cytogenetic parameters in chromosomal complex of the new Ukrainian winter wheat varieties and some relations amid value of cytological indexes and different concentrations of DMS (dimethylsulfate). We used the anaphases method for the investigation of chromosomal rearrangements and determination the mutagen action on plants and identification the nature of mutagen. We studied combined the sensitivity of genotype by the cytological analysis of mutagen treated population of wheat and revealed the reaction of different varieties depending upon t

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