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Journal articles on the topic 'Mutliplier'
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1
Lutfi, Robert. "Spectral integration and mutliple looks." Journal of the Acoustical Society of America 117, no. 4 (April 2005): 2536. http://dx.doi.org/10.1121/1.4788424.
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Schmutzler, R., K. Elkind-Hirsch, J. Simon, D. Hahn, J. L. McGuire, G. D. Hodgen, and D. Krebs. "Induktion mutlipler Follikulogenese durch pulsatile GnRH-Gabe: Bedeutung der GnRH-Pulsdauer." Archives of Gynecology and Obstetrics 242, no. 1-4 (March 1987): 543–44. http://dx.doi.org/10.1007/bf01783248.
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Behrens, D., T. Schoormann, and R. Knackstedt. "Developing an Algorithm to Consider Mutliple Demand Response Objectives." Engineering, Technology & Applied Science Research 8, no. 1 (February 20, 2018): 2621–26. http://dx.doi.org/10.48084/etasr.1819.
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Due to technological improvement and changing environment, energy grids face various challenges, which, for example, deal with integrating new appliances such as electric vehicles and photovoltaic. Managing such grids has become increasingly important for research and practice, since, for example, grid reliability and cost benefits are endangered. Demand response (DR) is one possibility to contribute to this crucial task by shifting and managing energy loads in particular. Realizing DR thereby can address multiple objectives (such as cost savings, peak load reduction and flattening the load profile) to obtain various goals. However, current research lacks algorithms that address multiple DR objectives sufficiently. This paper aims to design a multi-objective DR optimization algorithm and to purpose a solution strategy. We therefore first investigate the research field and existing solutions, and then design an algorithm suitable for taking multiple objectives into account. The algorithm has a predictable runtime and guarantees termination.
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Hsieh, Frank Y., Elizabeth Tengstrand, Teresa M. Pekol, Roberto Guerciolini, and Gerald Miwa. "Elucidation of potential bortezomib response markers in mutliple myeloma patients." Journal of Pharmaceutical and Biomedical Analysis 49, no. 1 (January 2009): 115–22. http://dx.doi.org/10.1016/j.jpba.2008.09.053.
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Toh Tin-Lam and Chew Tuan-Seng. "The Non-Uniform Riemann Approach to the Mutliple Itô-Wiener Integral." Real Analysis Exchange 29, no. 1 (2004): 275. http://dx.doi.org/10.14321/realanalexch.29.1.0275.
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Webster, Henry H., and Jan J. Hacker. "Mutliple Use: Improving on a Good Idea, and Avoiding a Red Herring." Forestry Chronicle 62, no. 4 (August 1, 1986): 262–64. http://dx.doi.org/10.5558/tfc62262-4.
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For purposes of management, forest land should be divided into three categories: areas to be managed primarily for natural values, areas to be managed primarily for developed recreation and areas where intensive vegetation management will be concentrated. Major changes in land tenure are substantially an energy sink that consume large amounts of effort while producing little useful result.
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Matusik, Sharon F., and Michael B. Heeley. "Absorptive Capacity in the Software Industry: Identifying Dimensions That Affect Knowledge and Knowledge Creation Activities." Journal of Management 31, no. 4 (August 2005): 549–72. http://dx.doi.org/10.1177/0149206304272293.
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The ability of the firm to effectively use external knowledge (its absorptive capacity) is important to firm competitiveness and innovativeness. However, the wide array of approaches to studying absorptive capacity has obscured our understanding of what drives the effective use of external knowledge. The authors show that absorptive capacity is composed of mutliple dimensions: (a) the firm’s relationship to its external environment; (b) the structure, routines, and knowledge base of the main value creation group(s); and (c) individuals’ absorptive abilities. Their data illustrate that each of these dimensions contributes to increased knowledge or knowledge creation activities.
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Tanjung, Widya Nurcahayanty, and Tiara Juanita. "Optimasi Penyusunan Anggaran Penjualan Menggunakan Lagrange Multiplier." JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI 3, no. 1 (December 5, 2017): 10. http://dx.doi.org/10.36722/sst.v3i1.179.
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<div class="WordSection1"><p class="ListParagraph1"><em>Abstrak</em> - <strong>Optimasi keuntungan dapat dicapai melalui berbagai macam cara, salah satunya adalah dengan merencanakan dan mengendalikan anggaran penjualan. Perencanaan dan pengendalian penjualan yang dirancang dengan baik dan tepat diharapkan mampu membantu dalam mencapai target penjualan agar memperoleh laba yang optimal. Pada umumnya, anggaran penjualan disusun terlebih dahulu sebelum menyusun anggaran lainnya. Tujuan utama pembuatan anggaran ini adalah untuk mengurangi ketidakpastian dimasa depan, memasukkan pertimbangan atau keputusan manajemen dalam proses perencanaan, memberikan informasi dalam <em>profit planning control, </em>serta mempermudah pengendalian penjualan. Metode Lagrange adalah metode yang digunakan untuk menentukan titik maksimum dan minimum suatu fungsi yang diiringi dengan persyaratan atau kendala yang harus dipenuhi. Metode ini berguna untuk memperoleh nilai-nilai maksimum relatif atau minimum relatif<em> </em>dari fungsi f(x,y) yang dipengaruhi oleh fungsi persyaratan g(x,y)=0. Langkah pertama yang dilakukan dalam optimasi anggaran ini yaitu melakukan peramalan agregat permintaan dilanjutkan dengan disagregasi permintaan ke setiap <em>region</em> berdasarkan kontribusi penjualan, kemudian menyusun anggaran penjualan dengan metode <em>Lagrange Mulitplier</em> hingga diperoleh keuntungan yang optimal. Berdasarkan hasil agregasi penjualan, jumlah produk yang harus dijual yaitu sebesar 33,331 kardus. Jumlah alokasi untuk setiap region berdasarkan hasil disagregasi penjualannya yaitu sebesar 4,267 kardus untuk Jabotabek, 611 kardus untuk <em>West Java</em>, 900 kardus untuk <em>West Outer Islands</em>, 318 kardus untuk <em>Central Java</em>, 400 kardus untuk <em>East OI 2</em>, 645 kardus untuk <em>EOI</em> (<em>Dummy</em>), 25 kardus untuk <em>EAST OI 1</em>, dan 26,167 kardus untuk <em>Non XYZ Brand</em>. Dengan demikian, jumlah anggaran penjualan tahun 2014 yaitu sebesar Rp6.594.350.758,- dengan jumlah keuntungan optimal yang dapat diperoleh perusahaan sebesar Rp 4.035.316.605,- atau sama dengan 61% dari jumlah anggaran penjualan.</strong></p><p class="ListParagraph1"><strong> </strong></p><p class="ListParagraph1"><strong><em>Kata Kunci – </em></strong><em>Optimasi, Anggaran penjualan, Lagrange Multiplier, Peramalan<strong></strong></em></p></div><strong><br clear="all" /> </strong><div class="WordSection2"> </div><em><br clear="all" /> </em><p class="ListParagraph1"><em>Abstract</em> <strong>– Many ways can be cultivated to reach profit optimization, such as planning and controlling in sales budgeting can be used as a method. Good in sales planning and controlling might be help to achieve sales target as an effort to get optimize profit. In general, sales’ planning is arranged as a first step before creating another budgeting plan. The main objectives in this work are minimizing uncentanty in the future, considering management judgment in planning process, giving information in profit planning control, and simplying sales control. Lagrange method can be used to determine optimum and minimum points from a function which followed by bounderies that must be filled. This method is useful to calculate relatives maximum or relatives minimum numbers from a function f(x,y) that influenced by requirement function g(x,y)=0. To finish optimizing budgeting plan, firstly, calculating the demand aggregate planning therefore continued by demand disagregations to all region based on their sales contributions. Moreover, followed by compiling sales budgeting using Lagrange Mutliplier method’s to obtain optimum profit. Based on sales aggregation result, number of product should be sales are 33.331 cartons. Number of allocation for each regions followed by sales agregations results are 4.267 cartons for Jabotabek, 611 cartons for <em>West Java</em>, 900 cartons for <em>West Outer Islands</em>, 318 cartons for<em> Central Java</em>, 400 cartons for<em> East OI 2</em>, 645 cartons for<em> EOI</em> (<em>Dummy</em>), 25 cartons for<em> EAST OI 1</em>, and 26,167 cartons for<em> Non XYZ Brand</em>. Therefore, total sales budgeting in year 2014 is Rp 6.594.350.758,- and number of optimum profit that company earn is Rp 4.035.316.605,- or equal by 61% from total sales budgeting.</strong></p><p class="ListParagraph1"><strong> </strong></p><strong><em>Keyword – </em></strong><em>Optimization, sales budgeting, Lagrange Multiplier, Forecasting</em>
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TONG, NANNAN, JIE ZHANG, YOURAN CHEN, ZHUBO LI, YONGHUANG LUO, HUA ZUO, and XIAOYAN ZHAO. "Berberine sensitizes mutliple human cancer cells to the anticancer effects of doxorubicin in vitro." Oncology Letters 3, no. 6 (March 14, 2012): 1263–67. http://dx.doi.org/10.3892/ol.2012.644.
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Sano, Yukio, Kiyohiro Miyagi, and Koji Tokushima. "Dynamic Equilibrium Constitutive Relations of Copper Powder Within Dies Subjected to Mutliple Shock Compactions." Journal of Engineering Materials and Technology 111, no. 2 (April 1, 1989): 183–91. http://dx.doi.org/10.1115/1.3226452.
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An approximate dynamic equilibrium pressure p-specific volume V relation exists for porous materials of a simple type undergoing mutliple shock compaction processes. A copper powder medium in dies is assumed to be of such a type, and the relation is constructed when the medium is compacted by a punch. It is given by an expression in the form of p=(V−Vi)/[b{Vi(1−a)−V}], where Vi, a and b are the material constants. These constants are estimated by matching the computational and experimental results obtained for the mean green density of the medium. Similarly, a dynamic equilibrium lateral pressure p1-specific volume V relation is also estimated for the medium after being given by p1=αp2+βp for ρ<3430 kg/m3, where α and β are the material constants and ρ is the density, while p1=0.5(Vsolid/V)νp+c for ρ≧3430 kg/m3, where Vsolid is the specific volume of solid copper, ν the material constant, and the contant c continuously connects the lateral pressures of the above two equations at ρ=3430 kg/m3. The compaction processes analyzed using the estimated relations agree favorably with the powder particle movement and shock wave front paths from experiments, suggesting the validity of the simple type assumption and that of the estimated relationships.
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Mignard, F., M. Badiali, P. L. Bernacca, H. Bernstein, D. Cardini, A. Emanuele, J. L. Falin, M. Froeschlé, R. Hering, and G. Prezioso. "HIPPARCOS First Results in the Double Star Processing by the FAST Consortium." International Astronomical Union Colloquium 135 (1992): 403–11. http://dx.doi.org/10.1017/s0252921100006886.
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AbstractAfter the processing of one year of observations carried out by HIPPARCOS it is possible to provide quantitative results as to the number of new double and multiple stars to be detected and the real capacity of this mission to perform relative astrometry on double stars. We present and discuss the methods developed to this end and include the first results concerning the detection statistics and the determination of separation and position angle for double stars. About 16,000 stars have been recognized as non-single, including 9,000 already known as double and mutliple before the mission. Also, a subset of 10,500 stars have been successfully solved for their relative coordinates with an accuracy in the range of 3 to 10 mas.
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Downes, Andrew, Rabah Mouras, and Alistair Elfick. "Optical Spectroscopy for Noninvasive Monitoring of Stem Cell Differentiation." Journal of Biomedicine and Biotechnology 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/101864.
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There is a requirement for a noninvasive technique to monitor stem cell differentiation. Several candidates based on optical spectroscopy are discussed in this review: Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and coherent anti-Stokes Raman scattering (CARS) microscopy. These techniques are briefly described, and the ability of each to distinguish undifferentiated from differentiated cells is discussed. FTIR spectroscopy has demonstrated its ability to distinguish between stem cells and their derivatives. Raman spectroscopy shows a clear reduction in DNA and RNA concentrations during embryonic stem cell differentiation (agreeing with the well-known reduction in the nucleus to cytoplasm ratio) and also shows clear increases in mineral content during differentiation of mesenchymal stem cells. CARS microscopy can map these DNA, RNA, and mineral concentrations at high speed, and Mutliplex CARS spectroscopy/microscopy is highlighted as the technique with most promise for future applications.
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Yaseen, Saif Ghazi, S. A. Ahmed, M. F. Johan, R. Kiron, and Aqil Mohammad Daher. "Evaluation of serological transfusion-transmitted viral diseases and mutliplex nucleic acid testing in malaysian blood donors." Transfusion and Apheresis Science 49, no. 3 (December 2013): 647–51. http://dx.doi.org/10.1016/j.transci.2013.07.003.
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Zięba, Tomasz, and Dariusz Uciński. "Mobile Sensor Routing for Parameter Estimation of Distributed Systems Using the Parallel Tunneling Method." International Journal of Applied Mathematics and Computer Science 18, no. 3 (September 1, 2008): 307–18. http://dx.doi.org/10.2478/v10006-008-0028-5.
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Mobile Sensor Routing for Parameter Estimation of Distributed Systems Using the Parallel Tunneling MethodThe paper deals with the problem of optimal path planning for a sensor network with mutliple mobile nodes, whose measurements are supposed to be primarily used to estimate unknown parameters of a system modelled by a partial differential equation. The adopted framework permits to consider two- or three-dimensional spatial domains and correlated observations. Since the aim is to maximize the accuracy of the estimates, a general functional defined on the relevant Fisher information matrix is used as the design criterion. Central to the approach is the parameterization of the sensor trajectories based on cubic B-splines. The resulting finite-dimensional global optimization problem is then solved using a parallel version of the tunneling algorithm. A numerical example is included to clearly demonstrate the idea presented in the paper.
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Colman, S., B. A. O'Leary, A. J. Palmer, and R. Simmons. "The Impact of Mutliple Sclerosis Severity on Quality of Life, Stress, Depression and Social Support Needs." Value in Health 17, no. 7 (November 2014): A809—A810. http://dx.doi.org/10.1016/j.jval.2014.08.543.
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Matsuo, Hiroshi, H. Harry Asada, and Yukio Takeda. "Design of a Novel Mutliple-DOF Extendable Arm With Rigid Components Inspired by a Deployable Origami Structure." IEEE Robotics and Automation Letters 5, no. 2 (April 2020): 2730–37. http://dx.doi.org/10.1109/lra.2020.2970976.
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Gkonis, P., D. Kaklamani, I. Venieris, C. Dervos, M. Chrysomallis, K. Siakavara, and G. Kyriakou. "On the Reduction of Transmission Complexity in MIMO-WCDMA Frequency-Selective Fading Orientations via Eigenvalue Analysis." Electronics 7, no. 10 (October 5, 2018): 239. http://dx.doi.org/10.3390/electronics7100239.
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In this paper, a novel transmission strategy for Mutliple Input Multiple Output Wideband Code Division Multiple Access (MIMO-WCDMA) orientations operating in frequency-selective fading environments is investigated, in terms of overall algorithmic complexity reduction. To this end, Principal Component Analysis (PCA) is employed on the received data matrix, in order to define the significant terms that are taken into account during transmission matrix formulation. According to the presented results, feedback information of only the primary eigenvector of the corresponding covariance matrix of the received data matrix is required, in order to maintain the mean Bit Error Rate (BER) at acceptable levels. In particular, a complexity reduction of up to 10% can be achieved, when comparing BER values derived by the selection of all components of the received covariance matrix during transmission matrix formulation, and the corresponding BER when selecting half of the components. This reduction is maintained to 10%, when considering a realistic four-element antenna design; however, in this case mean BER inaccuracy is further reduced to 1%.
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Peiris, Hassendrini N., Kanchan Vaswani, Olivia Holland, Yong Qin Koh, Fatema B. Almughlliq, Sarah Reed, and Murray D. Mitchell. "Altered productions of prostaglandins and prostamides by human amnion in response to infectious and inflammatory stimuli identified by mutliplex mass spectrometry." Prostaglandins, Leukotrienes and Essential Fatty Acids 154 (March 2020): 102059. http://dx.doi.org/10.1016/j.plefa.2020.102059.
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Bygrave, Desiree, and Regina Wright. "Weight Status Influences Carotid Intima-Media Thickness to Executive Function Among Older Adults." Innovation in Aging 4, Supplement_1 (December 1, 2020): 367–68. http://dx.doi.org/10.1093/geroni/igaa057.1183.
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Abstract Carotid atherosclerosis has emerged as an early predictor of reduced cognitive function. Underlying this association are risk factors, such as overweight and obesity, that promote carotid atherosclerosis and poor cognitive outcomes. Given the prevalence of overweight and obesity among older adults, there is a critical need to better understand how atherosclerosis influences cognitive function in the context of elevated weight. To address this gap, the current study examined relations between carotid atherosclerosis (carotid intima-media thickness [IMT]), and attention (Trailmaking Test) and executive function (Verbal Fluency Test) performance, and whether they varied as a function of weight status (body mass index [BMI] classification). Data were analyzed from 162 older adults (mean age = 68.43y, 34% male, 41% African American), free of major disease. Mutliple regression and analysis of variance analyses, adjusted for age, sex, education and mean arterial pressure, showed a statistically significant IMT x BMI interaction for Verbal Fluency performance (p=.04) and a trending IMT x BMI interaction for Trailmaking A performance (p=.05). Simple effects analysis of IMT and Verbal Fluency performance showed that this association was most pronounced among those who are obese. Findings suggest atherosclerosis may influence executive function in the context of obesity among older adults. As the development of carotid atherosclerosis is strongly related to aging, our findings suggest that maintaining a healthy weight may reduce its impact on executive function in older adulthood.
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Levesque, Barrett, Kristen Taylor Meadows, Akshay Buch, Michael Flynn, Kevin Peters, Allan Olson, Jinshan Shen, et al. "P066 GB004, A NOVEL GUT-TARGETED PROLYL HYDROXYLASE INHIBITOR FOR INFLAMMATORY BOWEL DISEASE: FIRST-IN-HUMAN, MUTLIPLE-DOSE STUDY IN HEALTHY SUBJECTS WITH GUT BIOPSIES." Gastroenterology 158, no. 3 (February 2020): S15—S16. http://dx.doi.org/10.1053/j.gastro.2019.11.072.
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Levesque, Barrett, Kristen Taylor Meadows, Akshay Buch, Michael Flynn, Kevin Peters, Allan Olson, Jinshan Shen, et al. "P066 GB004, A NOVEL GUT-TARGETED PROLYL HYDROXYLASE INHIBITOR FOR INFLAMMATORY BOWEL DISEASE: FIRST-IN-HUMAN, MUTLIPLE-DOSE STUDY IN HEALTHY SUBJECTS WITH GUT BIOPSIES." Inflammatory Bowel Diseases 26, Supplement_1 (January 2020): S9—S10. http://dx.doi.org/10.1093/ibd/zaa010.023.
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Abstract Background GB004 is a small molecule prolyl hydroxylase inhibitor (PHDi) that stabilizes hypoxia inducible factors (HIF1-α), key transcription factors involved in the protective cellular responses at the intersection of hypoxia and inflammation. GB004 was selected based on its gut-targeted profile to limit systemic on-target effects associated with HIF1-α stabilization. Consistent with this, orally administered GB004 in a healthy non-human primate model engaged HIF-related genes in the gut, and, in animal models of colitis, demonstrated a significant reduction in disease activity, improvements in histologic measures, and greater exposure in GI tissue relative to plasma. GB004 is in clinical development for treatment of inflammatory bowel disease (IBD) and was shown to be safe in a single ascending dose study. The study described here evaluates the safety, tolerability, and pharmacokinetics (PK) of multiple daily doses of GB004 in plasma and colon biopsies. Methods This was a randomized, double-blind, placebo-controlled, multiple dose, Phase 1a study conducted in healthy subjects at a single site in Canada. Three dose levels of GB004 formulated as a solution or placebo solution were administered orally once a day for 8 days; safety and PK were evaluated. Plasma levels of HIF target genes EPO and VEGF were determined by immunoassays from samples collected at pre-dose, 4, 8, and 12 hours post dose on Day 1 and Day 7. Colon biopsies were obtained one day prior to first dose and at Day 8. Results 42 subjects (20 male and 22 female) were dosed. No serious adverse events or deaths were recorded. The most commonly observed adverse event in GB004-treated subjects was dizziness (31%;10/22); all events were mild and did not result in study drug discontinuation. There were no identified risks of GB004. Following oral dosing, GB004 was rapidly absorbed and eliminated from the systemic circulation, with a median time to maximum concentration of 0.5 hour for all doses. Both Cmax and AUC of GB004 increased in a dose-dependent manner on Day 1 and 7. Concentrations of GB004 measured in colon biopsies were greater than concentrations in the plasma at the time of biopsy. Changes in plasma EPO or VEGF levels were similar for GB004 and placebo with no dose-related effects observed. Conclusions This study demonstrated that multiple daily doses of GB004 solution were safe and tolerable. The PK profile was consistent with its intended preferential exposure in the gut. In support of the gut-targeted exposure, HIF target genes EPO and VEGF were not modulated in plasma. A clinical study of GB004 is ongoing in patients with ulcerative colitis to explore safety, PK, and pharmacodynamics both systemically and within colonic tissue (NCT03860896). A tablet formulation is also being developed.
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Ricklefs, Franz, Ines Stevic, Christian Mende, Joshua Welsh, Jennifer Jones, Manfred Westphal, Katrin Lamszus, and Sven Eicker. "BIOM-09. MULTIPLEX ANALYSIS OF CSF EXTRACELLULAR VESICLES OF INTRASPINAL TUMORS." Neuro-Oncology 22, Supplement_2 (November 2020): ii3. http://dx.doi.org/10.1093/neuonc/noaa215.009.
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Abstract BACKGROUND: Extracellular vesicles (EVs) play an important role in cell-cell communication in different types of tumors, carrying multiple layers of biological functional molecules, including proteins, RNA, DNA and lipids. We previously demonstrated that extracellular vesicles (EV) from central nervous system tumors reflect the molecular subtype of the original tumor and mediate an exchange of pro-oncogenic signals. Their implication as biomarkers in tumor disease is under current investigation. It is unclear, however, to what extent cerebrospinal fluid (CSF) EVs from intraspinal tumors are utilizable for diagnostical purposes and how their marker profiles overlap with EVs derived from non tumorous EVs. We analyzed CSF EVs of intraspinal tumors to define CSF EV profiles that allow tumor subtype classification. METHODS: EVs were isolated from CSF of patients suffering from intraspinal meningioma (n=5), ependymoma (n=7) and neurinoma (n=5). Patients suffering from normal pressure hydrocephalus were used as controls (n=5). EVs were analyzed by multiplex bead based assay, immunoblotting, electron microscopy and NTA. RESULTS: CSF EVs were 97.21 ± 3.37nm (intraspinal tumor patients) and 101.6 ± 3.68nm (controls) in sizes and showed vesicular structures by electron microscopy. Particle number were not significantly different between both groups (p = 0.103). Using our 37 protein mutliplex EV profiling kit we found 29 proteins to be expressed in a sufficient manner on CSF EVs. CSF EVs of intraspinal meningioma showed elevated CD62P, HLA-DR, CD40, CD42a and CD45 expression levels, while ependymoma showed decreased levels of CD9, CD63, CD81, whereas neurinomas had elevated levels of SSEA-3 and CD25. CONCLUSION: This is the first comprehensive analysis of CSF EV of intraspinal tumor patients. CSF EV display distinct subpopulations that may allow tumor classification and long-term surveillance. However as tumor-specific EVs may be rare, there is still the need to identify markers that can enrich tumor-specific EVs for molecular profiling.
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Lalu, Manoj M., Dean A. Fergusson, Wei Cheng, Marc T. Avey, Dale Corbett, Dar Dowlatshahi, Malcolm R. Macleod, et al. "Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis." F1000Research 8 (January 3, 2019): 11. http://dx.doi.org/10.12688/f1000research.15869.1.
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Introduction: Globally, stroke is the second leading cause of death. Despite the burden of illness and death, few acute interventions are available to patients with ischemic stroke. Over 1,000 potential neuroprotective therapeutics have been evaluated in preclinical models. It is important to use robust evidence synthesis methods to appropriately assess which therapies should be translated to the clinical setting for evaluation in human studies. This protocol details planned methods to conduct a systematic review to identify and appraise eligible studies and to use a network meta-analysis to synthesize available evidence to answer the following questions: in preclinical in vivo models of focal ischemic stroke, what are the relative benefits of competing therapies tested in combination with the gold standard treatment alteplase in (i) reducing cerebral infarction size, and (ii) improving neurobehavioural outcomes? Methods: We will search Ovid Medline and Embase for articles on the effects of combination therapies with alteplase. Controlled comparison studies of preclinical in vivo models of experimentally induced focal ischemia testing the efficacy of therapies with alteplase versus alteplase alone will be identified. Outcomes to be extracted include infarct size (primary outcome) and neurobehavioural measures. Risk of bias and construct validity will be assessed using tools appropriate for preclinical studies. Here we describe steps undertaken to perform preclinical network meta-analysis to synthesise all evidence for each outcome and obtain a comprehensive ranking of all treatments. This will be a novel use of this evidence synthesis approach in stroke medicine to assess pre-clinical therapeutics. Combining all evidence to simultaneously compare mutliple therapuetics tested preclinically may provide a rationale for the clinical translation of therapeutics for patients with ischemic stroke. Dissemination: Review findings will be submitted to a peer-reviewed journal and presented at relevant scientific meetings to promote knowledge transfer. Registration: PROSPERO number to be submitted following peer review.
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MacDonnell, Joseph. "Evaluating service user & carer experience of videoconferencing software during COVID-19 pandemic." BJPsych Open 7, S1 (June 2021): S38. http://dx.doi.org/10.1192/bjo.2021.152.
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AimsTo evaluate service user and carer experience of use of videoconferencing software (Microsoft Teams) during MDT meetings.To identify specific areas for improvementTo make changes based on these recommendationsMethod2 surveys were distributed to inpatients and their carers on a functional Older Adults inpatient ward (n = 21), including quantitative and qualitiative questions. The results from these were compiled, and on review, mutliple recommendations for improvement were made.Result90% of service users find it helpful to have family present over videoconferencing software during their MDT meetings, and 91% of carers feel involved and able to contribute when they do join in this way81% of carers have the technology available at home to use such software, but only 55% of them feel confident using it. 73% need more information on its use.60% of carers referenced poor staff skills with software as a barrier to its use, and 60% referenced poor organisation of meetings2 service users raised issue with the size of a small laptop screen not allowing them to see who was actually present over MS Teams, although none were concerned with issues around confidentiality and the use of such softwareSeveral service users, carers and members of community teams identified poor sound quality as an issue, both when joining over the software, and when present in the room.ConclusionWidespread use of videoconferencing software such as MS Teams is likely to continue beyond the end of the COVID-19 pandemic. Through discussion with the ward team, the IT department, the training department, and the local council, multiple changes were made to the service, as below. These form a recommended list of areas for improvement in other services.Availability of videoconferencing equipment (in addition to laptop)Dedicated videoconferencing microphone/speaker to improve sound qualityDisplay screenWebcamOrganisation of meetingsDesignating a chairperson to admit and introduce all participantsDesignating a meeting organiser to invite all necessary participantsStaff skillsLocal audit of staff familiarity with softwareIntroduction of mandatory training for staff on use of softwareCarer skills & access to equipmentInformation and support available from well-trained staffLiaison with other organisations including council and third sector about availablity of equipment loans and training for carers
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Chabas, Delphine, Nathalie Beaufils, Gerard Sebahoun, Regis Costello, J. Weiller, Jean-Robert Harle, and Jean Gabert. "New Detection Method of V617F JAK2 Mutation; Its Use in a Clinical Setting." Blood 108, no. 11 (November 16, 2006): 4889. http://dx.doi.org/10.1182/blood.v108.11.4889.4889.
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Abstract Background: A single point mutation in the Janus 2 tyrosine kinase gene leading to a V617F substitution has been described in a large group of hematological pathologies such as Polycythemia Vera (PV), Essential Thrombocytaemia (ET), Idiopathic Myelofibrosis (IM) and unclassified Myeloproliferative disorders (MPDs). Mutated JAK2 is an essential biomarker which improves the understanding and classification of MPDs and offers a new target for specific therapeutics. Methods: We adapted the V617F genotyping by amplification mutation system (ARMS) PCR described by AmyV Jones and Nicholas C.P Cross and combined it with a capillary electrophoresis performed on the Agilent Bioanalyseur 2100. DNA quantification was determined by βglobin gene amplification by quantitative PCR.100ng of samples and controls were genotyped by a DNA ARMS assay, using a primer pair that specifically amplifies the mutant sequence. We chose the homozygous HEL cell line as a positive control systematically tested in each run. We investigated the sensitivity of the method by testing serial dilutions of 100% V617F homozygous HEL DNA into a non mutated DNA of PBL. We compared the sensitivity of simplex ARMS PCR method using a primer pair that only amplifies the mutant sequence versus a multiplex ARMS PCR method using a two primer pairs to specifically amplify the normal and mutant sequence plus a positive control band in a single reaction. We genotyped over 6 months, 70 patients who had been screened for MPDs, BCR-ABL fusion negative, PV, ET, and isolated polycythaemia. Furthermore, we intend to collaborate with IPSOGEN SAS to compare our results with their new licensed JAK2 mutation test based on the pioneering work of Dr.Vainchenker. Results: Sensitivity of the mutliplex and simplex techniques respectively ranged from 100% to 1% and 100% to 0.1%. We found evidence that the sensitivity of the technique was imrpoved by using a simplex ARMS PCR followed by a capillary electrophoresis than a multiplex one. Of the 70 samples with a known or suspected diagnosis of MPD, 43(61%) were negative for V617F JAK2 mutation and 27(39%) were positive. The V617F JAK2 mutation was detected in 43% (3/7) PV, 42% (22/53) MPDs, BCR-ABL fusion gene negative, 25% (2/8) ET and none of isolated polycythaemia. Conclusions: The poor frequency of positive V617F V617F JAK2 mutation in patients screened for an evocated PV might be due to the inclusion in PV group of patients who do not meet diagnostic criteria for PV. The V617F JAK2 mutation in MPDs can be detected by various methods. ARMS associated with a capillary electrophoresis seems to be easy to use and reproductible for detection of single base G → T substitution in JAK2 mutation. In addition, the simplex approach improves the sensitivity of the technique leading to V617F JAK2 mutation. This qualitative test leads to the conclusions: presence of the V617F JAK2 mutation “or absence of detection of the V617F JAK2 mutation and is essential in diagnosis and classification of MPDs whereas quantitative approach will improve the management of therapeutic response when targeted therapy against V617F JAK2 mutation will be defined.
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Mishima, Yuji, Jens Lohr, Yu-Tzu Tai, Ludmila Flores, Yosra Aljawai, Jacob P. Laubach, Paul G. Richardson, et al. "Molecular Analysis Of Circulating Tumor Cells Identifies Mutations That Are Distinct From Those Present In The Bone Marrow Of Patients With Multiple Myeloma." Blood 122, no. 21 (November 15, 2013): 533. http://dx.doi.org/10.1182/blood.v122.21.533.533.
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Abstract Background Clonal evolution involves simultaneous evolution of multiple co-existant subclones. Recent studies have suggested that clonal heterogeneity is critical during the progression of Multiple Myeloma (MM). Circulating tumor cells (CTCs) have been identified in many patients with solid tumors and hematological malignancies. Recent studies have suggested that CTCs can be identified in patients with Multiple Myeloma. The aims of this study were to identify the phenotypic characteristics of CTCs in patients with Mutliple Myeloma at different stages of the disease, to determine whether somatic mutations present in the bone marrow clones are also identified in CTCs or whether specific subclones are more prone to enter the systemic circulation. These subclones may have a higher likelihood of inducing dissemination into extramedullary sites and potential for drug resistance. Methods We analyzed the peripheral blood samples of 466 patients diagnosed with Multiple Myeloma at different stages of progression. Two plasma cell leukemia patients were included in the study. Freshly collected peripheral blood was processed to obtain white blood cell fractions. The cells were stained with eight antibodies including CD19, CD38, CD138, CD45, CD56, CD28, CD44, and CD183 and CTCs were purified by gating on CD19-/CD38+/CD138+ cells. Among them, ten of the CTC samples were selected to analyze somatic mutation using whole exome sequencing. Briefly, 1µg of genomic DNA was extracted form sorted cells followed by shearing, end repair, and ligation to barcoded adaptors. The DNA was size-selected, subjected to exonic hybrid capture and sequenced on Illumina HiSeq flow cells with an average depth of coverage of 100x. Results Of the 466 samples analyzed, the number of CTCs identified ranged from 0.01% to 61% of total WBC count. CTCs were detected in 61.4% of all samples analyzed. CTCs were detected in 64.5% of relapsed MM, 63.4% of newly diagnosed MM, 24.0% of smoldering MM, and 25.0% of MGUS patients. Significant differences of the surface markers including CD45, CD28, CD56, and CD44 were not observed in the different stages of MM disease progression. For further characterization of CTCs, we performed whole exome sequencing of CTCs in 10 MM samples, of which 5 had sequencing of their matched tumor cells collected from BM as well as matched normal germline cells to examine whether circulating tumor cells possess any distinctive somatic mutations. The sequence analysis revealed that both CTCS and marrow restricted tumor cells have substantial numbers of protein-coding mutations. CTCs and bone marrow cells shared 5-38% similar mutations, while interestingly the rest of the mutations were exclusively present in either the CTCs or bone marrow samples. We identified a total of 347 somatic mutations, which included 199 CTC specific mutations. Several known driver mutations were observed, i.e. BRaf V600E mutation present in the CTC samples but not in the matching bone marrow samples in one patient. Twelve of these CTC mutations were shared at least in two patients including ZNF721, NBPH10, F5, and PRDM15. Conclusion These data suggest subclonal out growth of CTCs from one of the parent clones with acquisition of additional mutation over time outside of the bone marrow microenvironment. Further validation of the unique mutations in CTCs may provide mechanistic insight into myeloma cell dissemination, and so potentially inform treatment strategies. Disclosures: Tai: Onyx: Consultancy. Anderson:celgene: Consultancy; onyx: Consultancy; gilead: Consultancy; sanofi aventis: Consultancy; oncopep: Equity Ownership; acetylon: Equity Ownership. Munshi:Celgene Corporation: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Millennium: The Takeda Oncology Company: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Novartis Pharmaceuticals Corporation: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Onyx Pharmaceuticals Inc: Membership on an entity’s Board of Directors or advisory committees. Ghobrial:Noxxon: Research Funding; BMS: Advisory board, Advisory board Other, Research Funding; Onyx: Advisoryboard Other; Sanofi: Research Funding.
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Bi, Jayce, Pascal Lambert, Brett L. Houston, Leonard A. Minuk, Vi Dao, Rami Kotb, Donald S. Houston, Ryan Zarychanski, and Emily Rimmer. "Monoclonal Protein Response Trajectory and Survival in Newly Diagnosed Multiple Myeloma: A Retrospective Cohort Study." Blood 136, Supplement 1 (November 5, 2020): 24. http://dx.doi.org/10.1182/blood-2020-142271.
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Background: Multiple myeloma is a heterogenous plasma cell cancer characterized by expression of a monoclonal protein (M-protein) or free light chains (FLC). Although survival has improved over the past 15 years, outcomes are variable and not fully predicted by conventional prognostic markers. Survival is associated with depth and duration of response to treatment but it is not known if the trajectory of response is associated with survival. We hypothesized that the trajectory of M-protein over the first six months of treatment in patients with newly diagnosed multiple myeloma can identify distinct clinical groups and is an independent predictor of overall survival (OS). The objectives of our study are to: 1) Identify groups of patients with different M-protein trajectories using trajectory analysis; 2) Evaluate patient and illness factors associated with different M-protein trajectories; and 3) Determine whether M-protein trajectory is an independent predictor of OS in newly diagnosed multiple myeloma. Methods: We conducted a retrospective cohort review of all patients with newly diagnosed multiple myeloma in Manitoba between 2012 and 2017 who had a measurable M-protein at presentation and who were initially treated with bortezomib-based chemotherapy. Baseline characteristics and monthly response assessments up to six months were collected and analyzed using trajectory analysis. We used latent class mixed models (LCMM) to produce trajectory groups of M-protein response over time. We used the Bayesian Information Criterion and clinical validity characteristics to select the optimal trajectory model. We developed a multinomial logistic model to evaluate the association of patient and illness characteristics with M-protein trajectories. We constructed a multivariable Cox proportional hazard model adjusted for trajectory group, ISS stage, transplant status, LDH, renal failure and platelet count to evaluate the association of M-protein trajectory on OS in multiple myeloma. Results: 266 patients were included in the trajectory analysis. 154 (57.9%) were male. Mean age was 66.4 years (SD 10.1). 29 (10.9%) were classified as ISS stage 1, 80 (30.1%) as ISS stage 2, and 109 (41.0%) as ISS stage 3. The best fit trajectory model identified three trajectory groups representing distinct M-protein trajectories over time (Figure 1). We plotted the trajectory of the absolute value for M-protein as the percentage change from baseline did not separate the population into distinct groups. Baseline bone marrow plasma percentage (p<0.01), albumin (p<0.01), and hemoglobin (p<0.01) were significantly associated with trajectory group membership. The median follow-up was 2.74 years for the OS analysis. The median OS was not reached for the low group, 4.3 years for the moderate group, and 5.4 years for the high group. In a multivariable Cox proportional hazard model, we found that trajectory group was not significantly associated with OS (moderate group HR 1.18, 95%CI 0.48-2.91, high group HR 1.10, 95%Cl 0.62-1.88). Variables significantly associated with OS included ISS stage (p<0.025), LDH (p<0.022), platelet count (p<0.001), and receipt of a stem cell transplant (p<0.001). Discussion and Conclusions: In this retrospective cohort study of patients with newly diagnosed multiple myeloma, we identified three distinct groups based on their M-protein trajectory over time. The identified groups have different mean baseline M-protein values and follow different evolutionary patterns over time. While M-protein trajectory group was not associated with differences in OS, the small sample size and short follow-up may limit interpretation of the results. Our analyses only looked at the M-protein trajectory over the first six months after treatment start, which indicates an early response to treatment. It is possible this early response does not play a large role in the OS of patients with myeloma given the mutliple lines of chemotherapy they may receive. Further studies are planned to assess the achievement of a complete remission at one year or at renal recovery for patients affected with renal involvement. Alternative uses for M-protein trajectory analysis include the trajectory of M-protein prior to relapse or in patients with smoldering myeloma to identify who may benefit from earlier treatment. Disclosures Kotb: Takeda: Honoraria; Merck: Honoraria, Research Funding; Sanofi: Research Funding; Celgene: Honoraria; Janssen: Honoraria; Amgen: Honoraria; Karyopharm: Current equity holder in publicly-traded company.
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"Performance Analysis of Karatsuba Vedic Multiplier and Computation Sharing Multiplier in the Adaptive Filter Design." International Journal of Innovative Technology and Exploring Engineering 9, no. 2 (December 10, 2019): 4425–29. http://dx.doi.org/10.35940/ijitee.b7454.129219.
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As real time signals change continuously, adaptive filtering is required for noise cancellation. An adaptive filter is one whose characteristics can be modified by adjusting its parameters according to an optimization algorithm The adaptive filtering operations can be implemented as a sequence of logic operations on a Digital Signal Processing (DSP) chip,Gate Arrays such as FPGA or Application Specific Integrated Circuits. There is always a tradeoff in the parameters area, power and speed in VLSI. This paper provides the implementation of adaptive LMS Filter using different types of multiplier and its analysis for the various parameters. The LMS Filter is designed using conventional array multiplier, Computation Sharing Mutliplier(CSHM) and Karatsuba Vedic Multiplier. The results show 70% reduction in delay and 19% reduction in area on using Karatsuba Vedic Multiplier ofr adaptive filter design.
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"Mutliple drugs." Reactions Weekly 1647, no. 1 (April 2017): 216. http://dx.doi.org/10.1007/s40278-017-28908-0.
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Bisen, Ashwini, Rakesh Kumar Jha, and Nandkishor Bankar. "Vegan Diet and Mutliple Health Outcomes: A Review and Meta-analysis." Journal of Pharmaceutical Research International, July 17, 2021, 42–47. http://dx.doi.org/10.9734/jpri/2021/v33i37b32018.
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A recent development in social protest literature involves cultural activism centered largely on the subject of veganism; its health benefits and responses to diseases that already exist among us. This article brings you the data relating health benefits with the entire plant-based diet, based on numerous studies done around and about this subject, taking into account the health-related, social, and ethical aspects.
Aim: Vegan Diet and Multiple Health Outcomes: A Review and Meta-Analysis
Conclusion: Plant-based nutrition is something so simple, yet so profound and so inexpensive that one can ‘make health a habit’ and thus, can absolutely reverse most of our modern day killers.
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"668. Restricted HIV-1 Escape with miR-Based shRNAs Targeting Mutliple Conserved Genomic Sequences." Molecular Therapy 16 (May 2008): S249—S250. http://dx.doi.org/10.1016/s1525-0016(16)40071-7.
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Grippo, Mark, Gayle Zydlewski, Haixue Shen, and R. Andrew Goodwin. "Behavioral responses of fish to a current-based hydrokinetic turbine under mutliple operational conditions." Environmental Monitoring and Assessment 192, no. 10 (September 17, 2020). http://dx.doi.org/10.1007/s10661-020-08596-5.
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Brown, Jeffrey. "Design and operation of a distributed health data network." International Journal of Population Data Science 3, no. 4 (September 10, 2018). http://dx.doi.org/10.23889/ijpds.v3i4.1002.
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IntroductionSeveral large health data networks such as FDA Sentinel, PCORnet, and the Canadian Network of Observational Drug Effect Studies (CNODES) facilitate multi-site research using real-world electronic health data such administrative claims data, electronic health record data and registries. Experience in operation of mutliple health data networks will described.
Objectives and ApproachOver the past 15 years substantial progress has been made in developing the optimal network operational design, governance, and technical architecture to facilitate the creation and operation of large-scale distributed health data networks. The design, architecture, and operation of a sustainable health data network requires balancing the needs of the network stakeholders such as funders, data sources, investigators, and regulatory bodies while enabling rapid and efficient use of data to support evidence generation and decision making. Important topics include protection of patient privacy, security, data autonomy, distributed analytics, data quality, and protection of confidential information.
ResultsThe design and architecture of existing distributed health data networks provides guidance regarding the potential operational model for new networks and identifies areas of research to improve network functionality and capabilities. Most health data network adopt a common data model approach to facilitate multi-site querying and data quality assessment. This approach is coupled with distributed querying in which data partners maintain physical and operational control of their data. This design maximizes protection of confidential and proprietary information and minimizes the need to share patient-level data. Privacy-preserving distributed regression approaches and methods that obviate the need to share person-level data while generating robust results help to ensure network participation. Strong security and governance structures are also necessary for effective operation of a distributed network.
Conclusion/ImplicationsDistributed health data networks offer the opportunity to use real-world data for public health surveillance and comparative safety and effectiveness research across large populations. The operational design, technical and analytic architecture, and governance models of networks drive their acceptance and success.
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Wong, Katrina, BCIT School of Health Sciences, Environmental Health, Helen Heacock, and Frederick Shaw. "Evaluating the efficiency of chlorine removal from potable tap water using off-gassing, boiling, and filtration treatment methods." BCIT Environmental Public Health Journal, March 19, 2018. http://dx.doi.org/10.47339/ephj.2018.61.
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Background: One of the most frequent complaints to water distribution systems is the taste and odor of chlorine in consumer tap water. Chlorine is a common disinfectant used to inactivate and breakdown microbes and other contaminants. However, excess chlorine can result in an unpalatable chlorinous taste and odor. When water taste becomes too objectionable, consumers may search for alternative water sources, such as raw, untreated water that does not contain chemical additives. Raw, untreated water contains various contaminants, including disease-causing pathogens. To encourage consumers to drink treated tap water, and prevent disease, this study evaluated and compared the effectiveness of off-gassing, boiling and filtration as dechlorination methods for consumers to perform on their tap water. Method: Hach Method 8021 was performed to collect and analyse water samples following treatment with Off-gassing, Boiling and Filtration. Water samples were collected from BCIT SW1-1230. The Hach Pocket Colorimeter ™ II determined the free chlorine concentration of the water samples, and compared to a sample of untreated chlorinated tap water to see which method reduced chlorine concentrations the most. Results: Mean concentration of chlorine following off-gassing was determined to be 0.51 ppm, 0.24 ppm following boiling, and 0.55 ppm following filtration. It was determined that the boiling method was statistically significantly different from the mean values of chlorine concentration from the other two methods, as shown by the Kruskal-wallis test (P=0.000), and therefore was the most effective in dechlorinating tap water samples. This was further confirmed by the Scheffe’s Mutliple-Comparison Test and eyeball test. Conclusion: Based on the results, boiling water is the most effective method to dechlorinate potable tap water for consumer acceptability. The free chlorine levels found post-boiling were also found to be below the WHO’s threshold for tasting and smelling chlorine in drinking water (0.3 ppm), and above WHO’s minimum required 0.2 ppm chlorine residual. Therefore, drinking water following boiling will be safe for consumption, as well as free of chlorinous taste and smell. Public Health professionals can safely advise consumers of an effective method to encourage treated tap water consumption, and to discourage finding alternative water sources.
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Hachamovitch, Rory, Brian Griffin, Alan Klein, Benjamin Nutter, Irene Katzan, and Thomas H. Marwick. "Abstract 279: The Impact of Heart Failure on Depression and Quality of Life is Greater in Men than Women." Circulation: Cardiovascular Quality and Outcomes 5, suppl_1 (April 2012). http://dx.doi.org/10.1161/circoutcomes.5.suppl_1.a279.
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Background. Patients (pts) diagnosed with congestive heart failure (HF) have been reported to have more frequent depression and worsened health related quality of life (HRQOL). Although depression is more common in women than men in this condition, the impact of HF on depression and HRQOL in men versus women is unclear. We sought to examine the relationship between pt sex, HF diagnosis, and pt-perceived depression and HRQOL. Methods. Depression (PHQ-9) and HRQOL (EQ5D) data were collected using tablet computers from pts presenting for routine outpatient cardiovascular assessment at our institution between November, 2010 and December, 2011. Demographic, clinical, and historical data was collected as per routine. We examined the association of pt sex and clinical diagnosis of HF with instrument results after adjusting for potential confounding information using mutliple linear regression. Results. Of 3046 pts (age 61±15), 39% were female and 8.7% were diagnosed with HF. Overall, PHQ-9 was greater, and minor or major depression (PHQ-9≥10) was more frequent, in women than men (4.6±4.6 vs. 3.3±4.4; 14.0% vs. 8.9%, both p<0.05) and in HF pts than pts without HF (5.9±5.6 vs. 3.6±4.3, 22.0% versus 9.6%; both p<0.05). Similarly, HRQOL was worse in women than men (EQ-5D 0.80±0.18 vs. 0.87±0.16; p<0.01) and in HF pts than no HF (EQ-5D 0.76±0.18 vs. 0.85±0.17; p<0.01). However, the difference in PHQ-9 between pts with versus without HF was greater in men (6.23±6.06 vs. 3.02±4.06, p<0.01) than women (5.43±4.85 vs. 4.55±4.58, p=0.09). After adjusting for cardiovascular diagnoses, comorbidities, clinical and demographic data, multivariable modeling of PHQ-9 revealed a significant interaction between pt sex and HF diagnosis (p=0.001; see Figure) such that women had greater PHQ-9 scores compared to men without HF, but in the setting of HF, mens' PHQ-9 scores were greater. Modeling of EQ-5D also revealed that after risk-adjustment an interaction between HF diagnosis and sex was present with a similar pattern of findings. Conclusion. Although depression is more frequent and severe in women compared to men, and in pts with versus without HF, HF appears to impact depression severity more in men compared to women.