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Journal articles on the topic 'MVP'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kelley, Brian P., Abdul Mateen Chaudry, and Faisal F. Syed. "Developing a Mechanistic Approach to Sudden Death Prevention in Mitral Valve Prolapse." Journal of Clinical Medicine 11, no. 5 (2022): 1285. http://dx.doi.org/10.3390/jcm11051285.

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Sudden cardiac death (SCD) from ventricular fibrillation (VF) can occur in mitral valve prolapse (MVP) in the absence of other comorbidities including mitral regurgitation, heart failure or coronary disease. Although only a small proportion with MVP are at risk, it can affect young, otherwise healthy adults, most commonly premenopausal women, often as the first presentation of MVP. In this review, we discuss arrhythmic mechanisms in MVP and mechanistic approaches for sudden death risk assessment and prevention. We define arrhythmogenic or arrhythmic MVP (AMVP) as MVP associated with complex an

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YAMAMOTO, REI, DAISUKE ISHII, and HIROSHI KONNO. "A MAXIMAL PREDICTABILITY PORTFOLIO MODEL: ALGORITHM AND PERFORMANCE EVALUATION." International Journal of Theoretical and Applied Finance 10, no. 06 (2007): 1095–109. http://dx.doi.org/10.1142/s0219024907004561.

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The purpose of this paper is to show that an algorithm recently proposed by authors can in fact solve a maximal predictability portfolio (MPP) optimization problem, which is a hard nonconvex fractional programming optimization. Also, we will compare MPP with standard mean-variance portfolio (MVP) and show that MPP outperforms MVP and index. We believe that this paper is of interest to researchers and practitioners in the field of portfolio optimization.

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Yan, Qingsong, Junhua Kang, Teng Xiao, Haibing Liu, and Fei Deng. "MVP-Stereo: A Parallel Multi-View Patchmatch Stereo Method with Dilation Matching for Photogrammetric Application." Remote Sensing 16, no. 6 (2024): 964. http://dx.doi.org/10.3390/rs16060964.

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Multi-view stereo plays an important role in 3D reconstruction but suffers from low reconstruction efficiency and has difficulties reconstructing areas with low or repeated textures. To address this, we propose MVP-Stereo, a novel multi-view parallel patchmatch stereo method. MVP-Stereo employs two key techniques. First, MVP-Stereo utilizes multi-view dilated ZNCC to handle low texture and repeated texture by dynamically adjusting the matching window size based on image variance and using a portion of pixels to calculate matching costs without increasing computational complexity. Second, MVP-S

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Strom, Carolyn. "Designating the MVP." Reading Teacher 68, no. 2 (2014): 108–12. http://dx.doi.org/10.1002/trtr.1287.

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Oppenheimer, Stephen. "Editorial Comment: Is MVP an MVP in Ischemic Cerebral Events?" Stroke 34, no. 6 (2003): 1345. http://dx.doi.org/10.1161/01.str.0000075773.79199.9a.

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Nalliah, Chrishan J., Rajiv Mahajan, Adrian D. Elliott, et al. "Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis." Heart 105, no. 2 (2018): 144–51. http://dx.doi.org/10.1136/heartjnl-2017-312932.

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ObjectivesMitral valve prolapse (MVP) is commonly observed as a benign finding. However, the literature suggests that it may be associated with sudden cardiac death (SCD). We performed a meta-analysis and systematic review to determine the: (1) prevalence of MVP in the general population; (2) prevalence of MVP in all SCD and unexplained SCD; (3) incidence of SCD in MVP and (4) risk factors for SCD.MethodsThe English medical literature was searched for: (1) MVP community prevalence; (2) MVP prevalence in SCD cohorts; (3) incidence SCD in MVP and (4) SCD risk factors in MVP. Thirty-four studies

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Nugroho, Bayu Adi. "Dynamic risk-based optimization on cryptocurrencies." Journal of Capital Markets Studies 5, no. 1 (2021): 28–48. http://dx.doi.org/10.1108/jcms-01-2021-0002.

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PurposeIt is crucial to find a better portfolio optimization strategy, considering the cryptocurrencies' asymmetric volatilities. Hence, this research aimed to present dynamic optimization on minimum variance (MVP), equal risk contribution (ERC) and most diversified portfolio (MDP).Design/methodology/approachThis study applied dynamic covariances from multivariate GARCH(1,1) with Student’s-t-distribution. This research also constructed static optimization from the conventional MVP, ERC and MDP as comparison. Moreover, the optimization involved transaction cost and out-of-sample analysis from t

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Chen, Sin-Cih, Sudha Xirasagar, Ju-Chi Liu, et al. "A Population-Based Study of Healthcare Resource Utilization in Patients with Mitral Valve Prolapse." International Journal of Environmental Research and Public Health 17, no. 5 (2020): 1622. http://dx.doi.org/10.3390/ijerph17051622.

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This study investigated differences in the utilization of healthcare services between subjects with mitral valve prolapse (MVP) and comparison subjects using data from Taiwan’s National Health Insurance population-based database, 138,493 patients with MVP (study group) and 138,493 matched patients without MVP (comparison group). We calculated the utilization of healthcare services in the year 2016 for each study sample. Patients with MVP had more outpatient cardiological services during the year (5.3 vs. 0.7, p < 0.001) and higher outpatient cardiology costs (US$226.0 vs. US$30.8, p < 0.

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Wu, Xiaoping, Junyang Fang, Qiuping Huang, et al. "Major Vault Protein Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection in CRL2843CD163 Cell Lines and Primary Porcine Alveolar Macrophages." Viruses 13, no. 11 (2021): 2267. http://dx.doi.org/10.3390/v13112267.

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Porcine reproductive and respiratory syndrome (PRRS), a significant viral infectious disease that commonly occurs among farmed pigs, leads to considerable economic losses to the swine industry worldwide. Major vault protein (MVP) is a host factor that induces type Ⅰ interferon (IFN) production. In this study, we evaluated the effect of MVP on PRRSV infection in CRL2843CD163 cell lines and porcine alveolar macrophages (PAMs). Our results showed that MVP expression was downregulated by PRRSV infection. Adenoviral overexpression of MVP inhibited PRRSV replication, whereas the siRNA knockdown of M

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Chung, Jin-Hui, Yi-Ju Tsai, Ko-Long Lin, et al. "Comparison of Cardiorespiratory Fitness between Patients with Mitral Valve Prolapse and Healthy Peers: Findings from Serial Cardiopulmonary Exercise Testing." Journal of Cardiovascular Development and Disease 10, no. 4 (2023): 167. http://dx.doi.org/10.3390/jcdd10040167.

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Individuals with mitral valve prolapse (MVP) have exercise intolerance even without mitral valve regurgitation. Mitral valve degeneration may progress with aging. We aimed to evaluate the influence of MVP on the cardiopulmonary function (CPF) of individuals with MVP through serial follow-ups from early to late adolescence. Thirty patients with MVP receiving at least two cardiopulmonary exercise tests (CPETs) using a treadmill (MVP group) were retrospectively analyzed. Age-, sex-, and body mass index-matched healthy peers, who also had serial CPETs, were recruited as the control group. The aver

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Lv, Lizhi, Xinyue Lang, Simeng Zhang, et al. "Effectiveness and Safety of Mitral Valve Plasty in Patients with an Anomalous Origin of the Coronary Artery from the Pulmonary Artery." Journal of Cardiovascular Development and Disease 10, no. 2 (2023): 75. http://dx.doi.org/10.3390/jcdd10020075.

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The study aimed to determine the effectiveness and safety of anomalous coronary artery from pulmonary artery (ACAPA) patients with moderate or severe mitral valve regurgitation (MVR) receiving mitral valve plasty (MVP) concurrently. Consecutive ACAPA patients undergoing surgery between 2015 and 2021 were retrospectively included. Patients were divided into three groups: moderate MVR without MVP (non-MVP (moderate) N = 14), moderate MVR with MVP (MVP (moderate) N = 13), and severe MVR with MVP (MVP (severe) N = 13). The primary safety endpoint was in-hospital surgery-related complications. The

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Toomer, Katelynn A., Mengyao Yu, Diana Fulmer, et al. "Primary cilia defects causing mitral valve prolapse." Science Translational Medicine 11, no. 493 (2019): eaax0290. http://dx.doi.org/10.1126/scitranslmed.aax0290.

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Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for mitral valve surgery. MVP can cause arrhythmias, heart failure, and sudden cardiac death, and to date, the causes of this disease are poorly understood. We now demonstrate that defects in primary cilia genes and their regulated pathways can cause MVP in familial and sporadic nonsyndromic MVP cases. Our expression studies and genetic ablation experiments confirmed a role for primary cilia in regulating ECM deposition during cardiac development. Loss of primary cilia during development resulted in progressiv

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Schueller, Amy M., and Daniel B. Hayes. "Minimum viable population size for lake sturgeon (Acipenser fulvescens) using an individual-based model of demographics and genetics." Canadian Journal of Fisheries and Aquatic Sciences 68, no. 1 (2011): 62–73. http://dx.doi.org/10.1139/f10-129.

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Population viability analysis is a useful tool to explore the relationship between extinction risk and population size, but often does not include genetic factors. Our objectives were to determine minimum viable population size (MVP) for lake sturgeon ( Acipenser fulvescens ) and examine how inbreeding depression may affect MVP. Our individual-based model incorporated inbreeding depression in two ways: individuals with inbreeding coefficients above a threshold experienced inbreeding depression (threshold), and individuals experienced inbreeding depression at a rate related to their inbreeding

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Songia, Paola, Mattia Chiesa, Valentina Alfieri, et al. "Putative Circulating MicroRNAs Are Able to Identify Patients with Mitral Valve Prolapse and Severe Regurgitation." International Journal of Molecular Sciences 22, no. 4 (2021): 2102. http://dx.doi.org/10.3390/ijms22042102.

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Mitral valve prolapse (MVP) associated with severe mitral regurgitation is a debilitating disease with no pharmacological therapies available. MicroRNAs (miRNA) represent an emerging class of circulating biomarkers that have never been evaluated in MVP human plasma. Our aim was to identify a possible miRNA signature that is able to discriminate MVP patients from healthy subjects (CTRL) and to shed light on the putative altered molecular pathways in MVP. We evaluated a plasma miRNA profile using Human MicroRNA Card A followed by real-time PCR validations. In addition, to assess the discriminati

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Winkel, Doan, Justin Wilcox, and Atul Teckchandani. "The 60-Minute MVP." Entrepreneurship Education and Pedagogy 3, no. 4 (2019): 371–86. http://dx.doi.org/10.1177/2515127419870293.

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The 60-minute minimum viable product (MVP) exercise teaches critical aspects of the entrepreneurial mind-set and lean start-up methodology, namely, the iterative process of hypothesis testing through the creation of MVPs. In 60 minutes, with no prior technical expertise, students will work in teams to design a landing page, create a teaser video, and set up a way to gather information from prospective customers. The resulting low-fidelity MVP can subsequently be shared with prospective customers to gauge interest and be used as a starting point for the hypothesis testing process used in the le

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Theall, Michael. "MVP and Faculty Evaluation." New Directions for Teaching and Learning 2017, no. 152 (2017): 91–98. http://dx.doi.org/10.1002/tl.20271.

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Routsias, John G., Dionysia Marinou, Maria Mavrouli, Athanasios Tsakris, and Vassiliki C. Pitiriga. "Major Vault Protein/Lung Resistance-Related Protein: A Novel Biomarker for Inflammation and Acute Infections." Microorganisms 12, no. 9 (2024): 1762. http://dx.doi.org/10.3390/microorganisms12091762.

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Introduction: Vault particles are large cytoplasmic ribonucleoprotein particles that participate in inflammation. The aim of this study was to assess the diagnostic and prognostic value of major vault protein (MVP) in patients with inflammation, in order to determine whether MVP could be used as a biomarker for infection or inflammation. We also aimed to compare the diagnostic impact of MVP compared to other conventional measurements, such as CRP or white blood cell (WBC) counts. Methods: CRP and MVP levels were measured in 111 sera samples from 85 patients with inflammation admitted to a tert

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Lima, Sarah M., Antonios A. Pitsis, Timotheos G. Kelpis, et al. "Matrix Metalloproteinase Polymorphisms in Patients with Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP) and FMV/MVP Syndrome." Cardiology 138, no. 3 (2017): 179–85. http://dx.doi.org/10.1159/000477656.

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Background: It has been suggested that collagen abnormalities of the mitral valve are present in patients with floppy mitral valve (FMV)/mitral valve prolapse (MVP). Genetic factors determining collagen synthesis and degradation have not been well defined in these patients. This study was undertaken to determine whether selective polymorphisms of matrix metalloproteinase-2 (MMP2) or transforming growth factor-β (TGFβ), with known or putative effects on collagen turnover, are more frequent in FMV/MVP. Methods: Single nucleotide polymorphisms (SNPs) in select genes related to collagen turnover,

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Hashimoto, Ari, Tsukasa Oikawa, Shigeru Hashimoto, et al. "P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance." Journal of Cell Biology 213, no. 1 (2016): 81–95. http://dx.doi.org/10.1083/jcb.201510002.

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Drug resistance, metastasis, and a mesenchymal transcriptional program are central features of aggressive breast tumors. The GTPase Arf6, often overexpressed in tumors, is critical to promote epithelial–mesenchymal transition and invasiveness. The metabolic mevalonate pathway (MVP) is associated with tumor invasiveness and known to prenylate proteins, but which prenylated proteins are critical for MVP-driven cancers is unknown. We show here that MVP requires the Arf6-dependent mesenchymal program. The MVP enzyme geranylgeranyl transferase II (GGT-II) and its substrate Rab11b are critical for A

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Sonaglioni, Andrea, Antonino Bruno, Alessio Polymeropoulos, Gian Luigi Nicolosi, Michele Lombardo, and Paola Muti. "Prevalence of Mitral Valve Prolapse Among Individuals with Pectus Excavatum: A Systematic Review and Meta-Analysis." Diagnostics 14, no. 22 (2024): 2488. http://dx.doi.org/10.3390/diagnostics14222488.

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Background: During the last decades, a small number of studies reported a wide range of variability in the estimated prevalence of mitral valve prolapse (MVP) among individuals with pectus excavatum (PE). The present systematic review and meta-analysis has been primarily designed to summarize the main findings of these studies and to estimate the overall prevalence of MVP among PE individuals. Methods: All imaging studies assessing the prevalence of MVP in PE individuals vs. healthy controls, selected from PubMed and EMBASE databases, were included. The risk of bias was assessed by using the N

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Gonzalez, Efrain A., Claudia Pimentel, Ruby A. Natale, Benjamin A. Toll, Ariel Soffer, and Leonard Gralnik. "Psychiatric and medical co-morbidity in mitral valve prolapse." Irish Journal of Psychological Medicine 19, no. 1 (2002): 16–20. http://dx.doi.org/10.1017/s0790966700006790.

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AbstractObjective: Significant controversy continues to exist in the empirical literature regarding the diagnosis and treatment of mitral valve prolapse (MVP). In addition, there is also inconsistency in the correlation of anxiety disorders as co-existing with MVP, as well as cause and effect issues in terms of the role of the autonomic nervous system, MVP and panic attacks. Recent studies suggest that the co-morbidity of an anxiety disorder and clinical depression appears to increase the likelihood of MVP in predisposed patients. The objective of this review was to examine, clarify, and furth

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Tamborini, Gloria, Valentina Mantegazza, Marco Penso, et al. "Predictive Value of Pre-Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling." Journal of Cardiovascular Development and Disease 7, no. 4 (2020): 46. http://dx.doi.org/10.3390/jcdd7040046.

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The “ideal” management of asymptomatic severe mitral regurgitation (MR) in valve prolapse (MVP) is still debated. The aims of this study were to identify pre-operatory parameters predictive of residual MR and of early and long-term favorable remodeling after MVP repair. We included 295 patients who underwent MV repair for MVP with pre-operatory two- and three-dimensional transthoracic echocardiography (2DTTE and 3DTTE) and 6-months (6M) and 3-years (3Y) follow-up 2DTTE. MVP was classified by 3DTTE as simple or complex and surgical procedures as simple or complex. Pre-operative echo parameters

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Beyazal, Meryem, Utku Arman Orun, and Ilker Ufuk Sayici. "Are children with mitral valve prolapse more anxious?" Annals of Pediatric Cardiology 16, no. 5 (2023): 331–36. http://dx.doi.org/10.4103/apc.apc_126_23.

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ABSTRACT Background: Mitral valve prolapse (MVP) is a common valvular disease in children. Symptoms in children with MVP are not explained by the severity of mitral regurgitation alone. Hence, we sought to correlate symptom status with the incidence of anxiety disorder in this population. Materials and Methods: Groups were as follows: (a) MVP; n = 115; mean age: 13.5 ± 3.06 years and (b) control; n = 53; mean age: 15.1 ± 13.2. The Screen for Child Anxiety-Related Emotional Disorders (SCAREDs) scale was filled by all participants. The SCARED scores of 25 and above determined a warning for anxie

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Kalkan Akcay, Emine, Murat Akcay, Betul Seher Uysal, et al. "Impaired Corneal Biomechanical Properties and the Prevalence of Keratoconus in Mitral Valve Prolapse." Journal of Ophthalmology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/402193.

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Objective. To investigate the biomechanical characteristics of the cornea in patients with mitral valve prolapse (MVP) and the prevalence of keratoconus (KC) in MVP.Materials and Methods. Fifty-two patients with MVP, 39 patients with KC, and 45 control individuals were recruited in this study. All the participants underwent ophthalmologic examination, corneal analysis with the Sirius system (CSO), and the corneal biomechanical evaluation with Reichert ocular response analyzer (ORA).Results. KC was found in six eyes of four patients (5.7%) and suspect KC in eight eyes of five patients (7.7%) in

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Le Tourneau, Thierry, Jean Mérot, Antoine Rimbert, et al. "Genetics of syndromic and non-syndromic mitral valve prolapse." Heart 104, no. 12 (2018): 978–84. http://dx.doi.org/10.1136/heartjnl-2017-312420.

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Mitral valve prolapse (MVP) is a common condition that affects 2%–3% of the general population. MVP is thought to include syndromic forms such as Marfan syndrome and non-syndromic MVP, which is the most frequent form. Myxomatous degeneration and fibroelastic deficiency (FED) are regarded as two different forms of non-syndromic MVP. While FED is still considered a degenerative disease associated with ageing, frequent familial clustering has been demonstrated for myxomatous MVP. Familial and genetic studies led to the recognition of reduced penetrance and large phenotypic variability, and to the

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Yamashita, Shinji, Hideo Takeshima, Takashi Watanabe, and Kiyotaka Yokogami. "ANGI-05. ORIGIN OF MICROVASCULAR PROLIFERATION IN PILOCYTIC ASTROCYTOMA - MVP IN PILOCYTIC ASTROCYTOMA MIGHT PARTIALLY COMPRISE TUMOR-DERIVED CELLS." Neuro-Oncology 21, Supplement_6 (2019): vi31. http://dx.doi.org/10.1093/neuonc/noz175.116.

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Abstract Microvascular proliferation (MVP), an aberrant vascular structure containing multilayered mitotically active endothelial- and smooth-muscle cells/pericytes, is a histopathological hallmark of glioblastoma multiforme (GBM). Although MVP tends to be associated with high-grade glioma, it has also been detected in WHO grade I pilocytic astrocytoma (PA). However, little is known about the mechanism underlying its formation. Using TP53 point mutations as a marker for tumor-derived cells, we earlier reported that MVP was partially converted from tumor cells via mesenchymal transition. In the

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Ermakov, Simon, Radhika Gulhar, Lisa Lim, et al. "Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse." Heart 105, no. 14 (2019): 1063–69. http://dx.doi.org/10.1136/heartjnl-2018-314269.

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ObjectiveBileaflet mitral valve prolapse (MVP) with either focal or diffuse myocardial fibrosis has been linked to ventricular arrhythmia and/or sudden cardiac arrest. Left ventricular (LV) mechanical dispersion by speckle-tracking echocardiography (STE) is a measure of heterogeneity of ventricular contraction previously associated with myocardial fibrosis. The aim of this study is to determine whether mechanical dispersion can identify MVP at higher arrhythmic risk.MethodsWe identified 32 consecutive arrhythmic MVPs (A-MVP) with a history of complex ventricular ectopy on Holter/event monitor

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Możdżan, Maria, Monika Możdżan, Iwona Duraj, et al. "Mitral valve prolapse—arrhythmic faces of the valve disease." Exploration of Cardiology 1, no. 2 (2023): 72–87. http://dx.doi.org/10.37349/ec.2023.00009.

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Mitral valve prolapse (MVP) is a relatively common mitral valvulopathy and the most common cause of isolated primary mitral regurgitation (MR) requiring surgical repair. It affects about 1–3% of the general population. Although MVP is viewed as a benign condition, the association between MVP and sudden cardiac death (SCD) has been proven. Patients with MVP have a three times higher risk of SCD than the general population. The underlying mechanisms and predictors of arrhythmias, which occur in patients with MVP, are still poorly understood. However, some echocardiographic features such as mitra

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Pietras, Paulina, Marta Leśniczak-Staszak, Aldona Kasprzak, et al. "MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells." International Journal of Molecular Sciences 22, no. 22 (2021): 12121. http://dx.doi.org/10.3390/ijms222212121.

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Cancer cells show significant dysregulation of genes expression, which may favor their survival in the tumor environment. In this study, the cellular vault’s components MVP (major vault protein), TEP1 (telomerase-associated protein 1) and vPARP (vault poly(ADP-ribose) polymerase) were transiently or completely inhibited in U2OS cells (human bone osteosarcoma epithelial cells) to evaluate their impact on the cell proliferative and migratory capacity as well as on the development of their resistance to the drug vinorelbine. Comparative analysis of MVP protein expression level in normal colon tis

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Froom, P., T. Margulis, E. Grenadier, A. Palant, M. David, and E. Aghai. "Von Willebrand Factor and Mitral Valve Prolapse." Thrombosis and Haemostasis 60, no. 02 (1988): 230–31. http://dx.doi.org/10.1055/s-0038-1647035.

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SummaryThe levels of von Willebrand factor (vWF: Ag) were measured in 27 patients with mitral valve prolapse (MVP) and compared to 27 age matched controls. Decreased levels of vWF:Ag (<80%) were found in 59% (16/27) of those with MVP compared to only 7% (2/27) of the controls (p <0.001). Mean vWF: Ag levels were also significantly lower in those with MVP (68 ± 30% versus 100 ± 23%, p <0.001). In those with MVP and congestive heart failure secondary to ruptured chordae tendineae, however, the mean level of vWF:Ag was not significantly different from control values (95 ± 32). There was

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Vergara, Pasquale, Savino Altizio, Giulio Falasconi, Luigi Pannone, Simone Gulletta, and Paolo Della Bella. "Electrophysiological Substrate in Patients with Barlow’s Disease." Arrhythmia & Electrophysiology Review 10, no. 1 (2021): 33–37. http://dx.doi.org/10.15420/aer.2020.29.

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Mitral valve prolapse (MVP) is the most common valvular heart disease, affecting 2–3% of the general population. Barlow’s disease is a clinical syndrome characterised by MVP. Initially thought a benign condition, MVP is now recognised as a cause of sudden cardiac death and ventricular arrhythmias. The development of new imaging techniques has contributed recently to the identification of novel risk factors. Catheter ablation of ventricular arrhythmias in patients affected by MVP is traditionally considered challenging. In this review, the authors summarise the evidence on arrhythmogenesis in t

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Hsiao, Sheng-Yen, Shu-Fang Sun, Yuh-Ling Chen, and Tse-Ming Hong. "Abstract 2644: Investigating major vault protein promoting migration and its clinical relevance in oral squamous cell carcinoma." Cancer Research 85, no. 8_Supplement_1 (2025): 2644. https://doi.org/10.1158/1538-7445.am2025-2644.

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Abstract Introduction: Head and neck squamous cell carcinoma (HNSCC), particularly oral squamous cell carcinoma (OSCC), has emerged as a significant health concern in Taiwan. It is the sixth leading cause of cancer-related death in the country, posing major challenges to public health and healthcare systems. The limited treatment options for unresectable or metastatic HNSCC highlight the need for new therapeutic targets. Several studies have reported that major vault protein (MVP), the primary component of ribonucleoprotein particles known as vaults, plays a role in regulating drug resistance

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Rebischung, J. L., J. M. Vannetzel, J. Sauvaget, et al. "MVP versus (vs) MVP plus chemo-radiotherapy in stage III NSCLC: Preliminary results." European Journal of Cancer 33 (September 1997): S235. http://dx.doi.org/10.1016/s0959-8049(97)85858-3.

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Sonaglioni, Andrea, Gian Luigi Nicolosi, Antonino Bruno, Michele Lombardo, and Paola Muti. "Echocardiographic Assessment of Mitral Valve Prolapse Prevalence before and after the Year 1999: A Systematic Review." Journal of Clinical Medicine 13, no. 20 (2024): 6160. http://dx.doi.org/10.3390/jcm13206160.

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Background: Over the last five decades, a fair number of echocardiographic studies have evaluated the prevalence of mitral valve prolapse (MVP) in various cohorts of individuals, including heterogeneous study populations. The present systematic review has been primarily designed to summarize the main findings of these studies and to estimate the overall MVP prevalence in the general community. Methods: All echocardiographic studies assessing the MVP prevalence in various cohorts of individuals, selected from PubMed and EMBASE databases, were included. There was no limitation of time period. Th

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Huang, Jau-Kang, Shiang-Yun Huang, Chih-hsien Lee, Ing-Fang Yang, Ten-Fang Yang, and Yun-Ming Wang. "Effect of Age on Heart Rate Variability in Patients with Mitral Valve Prolapse: An Observational Study." Journal of Clinical Medicine 12, no. 1 (2022): 165. http://dx.doi.org/10.3390/jcm12010165.

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Age is an important determinant of heart rate variability (HRV) in healthy individuals. The incidence of arrhythmia is high in patients with mitral valve prolapse (MVP). However, the correlation of HRV in patients with MVP in different age groups is not well established. We presumed that increasing age would be prospectively associated with declining HRV measurement in MVP. Sixty patients with MVP and 120 control individuals were included and underwent 24 h HRV analysis. No significant difference was found in all parameters calculated in the time domain or in the frequency domain between the t

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Huang, Ming-Hsuan, Sheng-Hui Tuan, Yun-Jeng Tsai, et al. "Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse." Life 13, no. 2 (2023): 302. http://dx.doi.org/10.3390/life13020302.

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Patients with mitral valve prolapse (MVP) have been reported to have exercise intolerance. However, the underlying pathophysiological mechanisms and their physical fitness remain unclear. We aimed to determine the exercise capacity of patients with MVP through the cardiopulmonary exercise test (CPET). We retrospectively collected the data of 45 patients with a diagnosis of MVP. Their CPET and echocardiogram results were compared with 76 healthy individuals as primary outcomes. No significant differences regarding the patient’s baseline characteristics and echocardiographic data were found betw

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Sutovsky, Peter, Gaurishankar Manandhar, Jozef Laurincik, et al. "Expression and proteasomal degradation of the major vault protein (MVP) in mammalian oocytes and zygotes." Reproduction 129, no. 3 (2005): 269–82. http://dx.doi.org/10.1530/rep.1.00291.

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Major vault protein (MVP), also called lung resistance-related protein is a ribonucleoprotein comprising a major part (>70%) of the vault particle. The function of vault particle is not known, although it appears to be involved in multi-drug resistance and cellular signaling. Here we show that MVP is expressed in mammalian, porcine, and human ova and in the porcine preimplantation embryo. MVP was identified by matrix-assisted laser-desorption ionization-time-of-flight (MALDI-TOF) peptide sequencing and Western blotting as a protein accumulating in porcine zygotes cultured in the presence of

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Thyagarajan, Anita, Sayali Kadam, Langni Liu, et al. "Gemcitabine Induces Microvesicle Particle Release in a Platelet-Activating Factor-Receptor-Dependent Manner via Modulation of the MAPK Pathway in Pancreatic Cancer Cells." International Journal of Molecular Sciences 20, no. 1 (2018): 32. http://dx.doi.org/10.3390/ijms20010032.

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Studies, including ours, have shown that pro-oxidative stressors, such as chemotherapeutic agents, generate oxidized lipids with agonistic platelet-activating factor (PAF) activity. Importantly, recent reports have implicated that these PAF-agonists are transported extracellularly via microvesicle particles (MVPs). While the role of PAF-receptor (PAF-R) has been implicated in mediating chemotherapy effects, its significance in chemotherapy-mediated MVP release in pancreatic cancer has not been studied. The current studies determined the functional significance of PAF-R in gemcitabine chemother

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Liu, Qingling, Junlu Pan, Linrui Bao, et al. "Major Vault Protein Prevents Atherosclerotic Plaque Destabilization by Suppressing Macrophage ASK1-JNK Signaling." Arteriosclerosis, Thrombosis, and Vascular Biology, April 7, 2022. http://dx.doi.org/10.1161/atvbaha.121.316662.

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Background: Macrophages are implicated in atherosclerotic plaque instability by inflammation and degradation of extracellular matrix. However, the regulatory mechanisms driving these macrophage-associated processes are not well understood. Here, we aimed to identify the plaque destabilization-associated cytokines and signaling pathways in macrophages. Methods: The atherosclerotic models of myeloid-specific MVP (major vault protein) knockout mice and control mice were generated. Atherosclerotic instability, macrophage inflammatory signaling, and active cytokines released by macrophages were exa

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"MVP acquires Plastech." Reinforced Plastics 50, no. 11 (2006): 6. http://dx.doi.org/10.1016/s0034-3617(06)71171-7.

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Le Tourneau, T., C. Cueff, N. Piriou, et al. "P6490Paradoxycal restricted motion in diastole is a frequent finding in mitral valve prolapse/dystrophy patients." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz746.1080.

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Abstract Background Filamin-A mitral valve prolapse/dystrophy (FLNA-MVP) phenotype associates MVP and a paradoxical restricted motion in diastole. Purpose We aim to assess the association of mitral valve prolapse to restricted motion in diastole in MVP patients (restricted MVP). Methods We prospectively enrolled 475 MVP probands (64±13 years) and controls relatives. Patients underwent a clinical examination and a comprehensive echocardiographic analysis of mitral valve apparatus. Results Among 475 consecutive probands, 48 (10.1%, 95% CI 7.7–13.3) had both a MVP and a doming aspect in diastole.

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Mohty, Dania, Thomas A. Orszulak, Hartzell V. Schaff, Jean-Francois Avierinos, Jamil A. Tajik, and Maurice Enriquez-Sarano. "Very Long-Term Survival and Durability of Mitral Valve Repair for Mitral Valve Prolapse." Circulation 104, suppl_1 (2001). http://dx.doi.org/10.1161/circ.104.suppl_1.i-1.

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Background Mitral regurgitation (MR) due to mitral valve prolapse (MVP) is often treatable by surgical repair. However, the very long-term (>10-year) durability of repair in both anterior leaflet prolapse (AL-MVP) and posterior leaflet prolapse (PL-MVP) is unknown. Methods and Results In 917 patients (aged 65±13 years, 68% male), surgical correction of severe isolated MR due to MVP (679 repairs and 238 replacements [MVRs]) was performed between 1980 and 1995. Survival after repair was better than survival after MVR for both PL-MVP (at 15 years, 41±5% versus 31±6%, respectively; P =0.0003) a

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Norris, Russell, Kimberly Sauls, Ronen Durst, et al. "Abstract 18977: Non-Syndromic Mitral Valve Prolapse From Gene Mutations to Modifiable Mechanisms." Circulation 130, suppl_2 (2014). http://dx.doi.org/10.1161/circ.130.suppl_2.18977.

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Mitral valve prolapse (MVP) is a common disease affecting nearly 1 in 40 individuals. It is the leading surgical indication for mitral valve regurgitation. Despite a clear heritable component, the genetic etiology of non-syndromic MVP has remained elusive. Individuals from a large multigenerational family segregating non-syndromic MVP underwent capture sequencing of a previously linked interval on chromosome 11. We found a novel missense mutation in DCHS1, the human homologue of the Drosophila cell polarity gene dachsous (ds) that segregates with MVP in the family. The familial mutation reduce

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Yousefnezhad, Muhammad, and Daoqiang Zhang. "Local Discriminant Hyperalignment for Multi-Subject fMRI Data Alignment." Proceedings of the AAAI Conference on Artificial Intelligence 31, no. 1 (2017). http://dx.doi.org/10.1609/aaai.v31i1.10506.

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Multivariate Pattern (MVP) classification can map different cognitive states to the brain tasks. One of the main challenges in MVP analysis is validating the generated results across subjects. However, analyzing multi-subject fMRI data requires accurate functional alignments between neuronal activities of different subjects, which can rapidly increase the performance and robustness of the final results. Hyperalignment (HA) is one of the most effective functional alignment methods, which can be mathematically formulated by the Canonical Correlation Analysis (CCA) methods. Since HA mostly uses t

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Le Tourneau, T., C. Cueff, M. Marrec, et al. "P756 Paradoxycal restricted motion in diastole associated to mitral valve prolapse/dystrophy: a frequent finding." European Heart Journal - Cardiovascular Imaging 21, Supplement_1 (2020). http://dx.doi.org/10.1093/ehjci/jez319.419.

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Abstract Funding Acknowledgements PHRCI mitral 2012 Background Filamin-A mitral valve prolapse/dystrophy (FLNA-MVP) phenotype associates moderate MVP and a paradoxical restricted motion in diastole. Purpose We aimed to assess the association of MVP with restricted motion in diastole in MVP patients (restricted MVP). Methods We prospectively enrolled 433 MVP probands (57 ± 16 years). Patients underwent a clinical examination and a comprehensive echocardiographic analysis of mitral valve apparatus. Results Among the 433 probands, 27 (6.2%, 95% CI 3.9-8.5) had both a MVP and a doming aspect in di

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Pace, Nathalie, Jean-Marc Sellal, Clement Venner, et al. "Myocardial deformation in malignant mitral valve prolapse: A shifting paradigm to dynamic mitral valve–ventricular interactions." Frontiers in Cardiovascular Medicine 10 (April 12, 2023). http://dx.doi.org/10.3389/fcvm.2023.1140216.

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ObjectivesThis study sought to assess the value of myocardial deformation using strain echocardiography in patients with mitral valve prolapse (MVP) and severe ventricular arrhythmia and to evaluate its impact on rhythmic risk stratification.BackgroundMVP is a common valvular affection with an overly benign course. Unpredictably, selected patients will present severe ventricular arrhythmia.MethodsPatients with MVP as the only cause of aborted SCD (MVP-aSCD: ventricular fibrillation and monomorphic and polymorphic ventricular tachycardia) with no other obvious reversible cause were identified.

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Fernández-Friera, Leticia, Rafael Salguero, Luca Vannini, Ana Fidalgo Argüelles, Fernando Arribas, and Jorge Solís. "Mechanistic insights of the left ventricle structure and fibrosis in the arrhythmogenic mitral valve prolapse." Global Cardiology Science and Practice 2018, no. 1 (2018). http://dx.doi.org/10.21542/gcsp.2018.4.

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Mitral valve prolapse (MVP) is a common and benign condition. However, some anatomic forms have been recently associated with life-threatening ventricular arrhythmias and sudden cardiac death. Imaging MVP holds the promise of individualized MVP risk assessment. Noninvasive imaging techniques available today are playing an increasingly important role in the diagnosis, prognosis and monitoring of MVP. In this article, we will review the current evidence on arrhythmogenic MVP, with special focus on the utility of echocardiography and CMR for identifying benign and ‘‘malignant’’ forms of MVP. The

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Salvatori, Fabio, Cinzia Mincarelli, Paola Piccinni, and Salvatore Alborino. "Coils associated with micro vascular plug system for closing larger vessels: Technical note on a preliminary experience." Vascular, March 13, 2025. https://doi.org/10.1177/17085381251326997.

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Objectives The MVP™ Micro Vascular Plug System represents a plug indicated for embolisation of peripheral vasculature. It has a lower profile and can be deliverable through smaller catheters, but it can occlude vessels ≤9 mm. We propose a new embolisation technique based on the use of the MVP™ and detachable coils to embolise vessels of larger calibre. Materials and methods Through a 7-F sheath the plug is implanted without detaching it. Then, the vessel is navigated in parallel with a microcatheter through which some coils are detached using the bare portion of the MVP™ to anchor them. This w

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Zhang, Zhuo, Tingting Guo, and Xiangyu Zhao. "SIRT7‐Mediated MVP Desuccinylation Facilitates Tongue Squamous Cell Carcinoma Progression by Activating JAK2/STAT3 Pathway." Cell Biology International, June 30, 2025. https://doi.org/10.1002/cbin.70048.

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ABSTRACTMajor vault protein (MVP) plays a contributing role in multifarious cancers, and then its role in Tongue squamous cell carcinoma (TSCC) is uncomprehending. This study aimed to investigate the regulatory effect of MVP on malignant behavior of TSCC cells and its mechanism. We first pointed out the abnormal upregulation of MVP in tumor tissues by immunohistochemistry, western blot, and reverse transcription‐quantitative polymerase chain reaction assays. Depletion of MVP hindered TSCC cell viability, migration, and invasion and accelerated apoptosis. Mechanistically, depletion of MVP inact

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Delwarde, Constance, Romain Capoulade, Jean Mérot, et al. "Genetics and pathophysiology of mitral valve prolapse." Frontiers in Cardiovascular Medicine 10 (February 16, 2023). http://dx.doi.org/10.3389/fcvm.2023.1077788.

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Mitral valve prolapse (MVP) is a common condition affecting 2–3% of the general population, and the most complex form of valve pathology, with a complication rate up to 10–15% per year in advanced stages. Complications include mitral regurgitation which can lead to heart failure and atrial fibrillation, but also life-threatening ventricular arrhythmia and cardiovascular death. Sudden death has been recently brought to the forefront of MVP disease, increasing the complexity of management and suggesting that MVP condition is not properly understood. MVP can occur as part of syndromic conditions

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