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Pettersson, Maria. "Förebyggande av postoperativ myalgi." Thesis, Halmstad University, School of Social and Health Sciences (HOS), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-5222.
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Succinylcolin är ett icke-depolariserande muskelrelaxantia som används inom anestesisjukvård. En vanlig biverkning är postoperativ myalgi. Varför smärtan uppstår är inte helt klarlagd. Under många år har forskare runt om i världen försökt komma till rätta med problemet utan att helt lyckas.Olika läkemedel och strategier har prövats. En av de viktigaste uppgifter en sjuksköterska har är att förebygga och lindra lidande. Som anestesisjuksköterska finns det möjlighet att påverka den vård som ordineras. Syftet med studien var att undersöka vilka metoder som kan förebygga postoperativ myalgi orsakad av succinylcolin. En litteraturstudie baserad på tio vetenskapliga artiklar genomfördes. Resultatet visade att parecoxib preoperativt samt premedicinering med diklofenakplåster gav det bästa resultatet när det gäller reducerande av myalgi. Med hjälp av dessa så vanliga läkemedel kan onödigt lidande förebyggas och samhällsekonomiska resurser sparas.
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Jansson, Helena. "Har Q10 någon effekt på smärtan vid statininducerad myopati/myalgi?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-72831.
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Sammanfattning Bakgrund:Koenzym Q10 (Q10) syntetiseras i kroppen och återfinns med de högsta koncentrationerna i hjärta, lever och immunförsvarets celler. Det har en viktig roll när det agerar transportör av elektroner i andningskedjan. Q10 har även antioxiderande egenskaper, stärker cellmembran och motverkar fettsyraoxidation i mitokondrien och cellmembran. Nyare studier visar att ett tillskott av Q10 även förbättrar symptomen vid kronisk hjärtsvikt och minskar kardiovaskulära händelser.Vid förhöjda blodfetter är det mest använda läkemedlet statiner. De hämmar kolesterolsyntesen i levern och de påverkar även syntesen av Q10 vilken också sker mevalonatvägen. En av de vanligaste biverkningarna vid statinbehandling är muskelbesvären myopati och myalgi. Studier visar att dåligt fungerande mitokondrier och reducering av Q10 i serum kan relateras till statinbehandling. Syfte:Syftet med detta arbete har varit att undersöka om ett tillskott av Q10 har någon reducerande effekt på smärtan vid statininducerad myopati (SIM). Metod:Denna litteraturstudie baserades på sex vetenskapliga artiklar sökta via PubMed. Studierna skulle vara randomiserade, dubbelblinda kliniska studier gjorda på människor. Av sökningens 10 träffar erhölls 6 artiklar vilka var relevanta för att besvara denna studiens frågeställning. Resultat:Resultatet visade att Q10 inte har någon större effekt på smärtan vid SIM. Endast 2 av 6 studier visar att Q10 har en god effekt. Slutsats: För att kunna dra slutsats om Q10 har effekt eller inte vid SIM behövs fler randomiserade placebokontrollerade studier med jämförbara grupper och fler antal deltagare.
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Nygren, Karin, and Charlotte Glimstedt. "Pain modulation in patients with chronic lumbar myalgia : An experimental study." Thesis, Linnéuniversitetet, Institutionen för idrottsvetenskap (ID), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-26833.
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Syfte: Syftet med denna studie var att undersöka hur statisk muskelkontraktion och cold pressor test påverkar kroppsegna smärtreglerande system (”Exercise induced analgesia” (EIA) och ”Conditioned pain modulation” (CPM)) hos patienter med kronisk ländryggssmärta kännetecknad av lumbal myalgi (LM) jämfört med friska kontroller. Försökspersoner och metod: Tjugosex friska köns- och åldersmatchade personer och tjugosex LM-patienter deltog. De utförde standardiserad statisk muskelkontraktion med m. Erector spinae (ME) i form av rygglyft och kontraktion av m. Quadriceps femoris (MQ) i form av knäledsextension. För att bedöma CPM användes sk cold pressor test. Smärttrösklar för tryck (PPTs) mättes över m. Deltoideus (MD), m. Erector spinae (ME) samt över m. Quadriceps (MQ) i vila och under resp. efter kontraktionen/cold pressor test. Under kontraktion mättes PPTs över den arbetande muskeln respektive över de två vilande musklerna. Dessutom undersöktes PPTs och känsligheten för övertrösklig trycksmärta (P7) i vila på 8 olika punkter på kroppen. Resultat: Kvinnliga LM-patienter hade ökad känslighet för trycksmärta (PPT) och övertrösklig trycksmärta (P7) jämfört med köns- och åldermatchade friska kontroller, medan manliga LM-patienter paradoxalt nog hade minskad känslighet för övertrösklig trycksmärta. Beträffande EIA fann vi att LM-patienter och kontroller kunde aktivera lokal EIA under kontraktion med ME. Vi fann dessutom en minskad förmåga hos LM-patienter att rekrytera generaliserad EIA under kontraktion med MQ. Slutligen hade LM-patienterna en normal funktion av CPM. Slutsats: LM-patienter kunde aktivera lokal EIA under kontraktion av ME, men hade mindre effektiv generaliserad EIA jämfört med kontrollerna, trots normal funktion av CPM. Våra resultat tyder på att muskelarbete med smärtande ryggmuskler skulle kunna användas för att minska smärtkänslighet i det drabbade området.
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Olivier, Catherine. "Le syndrome "éosinophilie-myalgies" lié à la consommation de L. Tryptophane : à propos d'une observation." Montpellier 1, 1992. http://www.theses.fr/1992MON11084.
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Ross, Jessica L. "Peripheral Mechanisms of Ischemic Myalgia." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504803397585968.
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Frey, Daniela. "An experimental model of chronic myalgia." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66971.
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Objective: To develop a model of chronic jaw muscle allodynia using acidic saline infusion in humans. Methods: Buffered acidic (pH 5.1) or normal (pH 7.2) saline was infused into the masseter of 20 healthy subjects for 20 minutes. Sensory and motor tasks were conducted prior to infusion and 1, 24, 48, and 72 hours post-infusion. Results: Acidic saline induced mild pain during infusion, discomfort during motor tasks and mild allodynia that lasted for at least 24 hours. These effects were not different from those produced by normal saline. Sensory intensity during infusion was associated with levels of allodynia and sensory intensity during motor tasks for up to 3 days. Conclusion: Infusion of buffered solutions at pH 5.1 or 7.2 into the masseter produce mild pain and long-lasting allodynia and discomfort during jaw function. The intensity of these after-effects was strongly associated with the sensory intensity evoked by the infusion.Objectif: Le but de cette étude est de développer un modèle humain d'allodynie chronique des muscles de la mâchoire grâce à une perfusion de solution saline acide. Méthodes : Nous avons fait une perfusion pendant 20 minutes soit d'une solution tampon acide (pH 5.1) ou d'une solution saline (pH 7.2) au niveau du masséter chez 20 individus en santé. Des tâches motrices et sensorielles ont été effectuées avant et 1h, 24h, 48h et 72 heures après l'injection. Résultats: La solution tampon acide a induit une douleur modérée pendant la perfusion, un inconfort durant les tâches motrices et de l'allodynie pendant au moins 24 heures. Ces effets ne sont pas différents de ceux produit par l'injection de solution saline. L'intensité sensorielle ressentie pendant la perfusion est associée au niveau d'allodynie et à l'intensité sensorielle au cours des tâches motrices au cours des 3 jours suivants. Conclusion: La perfusion de solution tampon acide (pH 5.1) ou saline (pH 7.2) dans le muscle masséter a produit une douleur modérée, de l'inconfort et de l'allodynie persistante lors du fonctionnement de la mâchoire. L'intensité de ces répercussions est fortement liée à l'intensité sensorielle évoquée par la perfusion.
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Roumier, Anne-Sophie. "Rôle des chimiokines et de leurs récepteurs dans les hyperéosinophilies." Lille 2, 2003. http://www.theses.fr/2003LIL2P011.
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Mörk, Camilla, and Dahlberg Linda Welin. "Att leva med myalgisk encefalomyelit." Thesis, Sophiahemmet Högskola, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-3854.
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Bakgrund Myalgisk encefalomyelit är en komplex, kronisk, neurologisk sjukdom som kännetecknas av långvarig psykisk och fysisk utmattning. Detta tillsammans med många andra symtom som smärta, yrsel och influensaliknande symtom, där symtomen förvärras vid ansträngning. Sjukdomens etiologi och patofysiologi är fortfarande okänd vilket leder till misstro och missuppfattningar från sjukvården för personen som lever med myalgisk encefalomyelit. Syfte Syftet var att belysa personers erfarenheter av att leva med myalgisk encefalomyelit. Metod Litteraturöversikten är baserad på 18 vetenskapliga kvalitativa och kvantitativa originalartiklar. Dessa återfanns i databaserna CINAHL, PubMed och PsycINFO. De kvalitetsgranskades enligt Sophiahemmet Högskolas bedömningsunderlag modifierat utifrån Berg et al. (1999) och Willman et al. (2011). Dataanalysen gjordes med inspiration från Kristenssons (2014) integrerade analys. Resultat Tre kategorier framträdde i resultatet med utgångspunkt i personernas erfarenhet av: mötet med sjukvården, påverkan på det dagliga livet samt copingstrategier och framtidstro. Resultatet visade att personerna hade erfarenheter av brister i mötet med sjukvården, social isolering och resultatet visade vikten av att ha strategier för att hantera sin vardag. Slutsats Litteraturöversiktens fynd visar vad det innebär för personen att leva med myalgisk encefalomyelit och hur det är att dagligen påverkas av de karaktäristiska symtomen fatigue, smärta och i och med det isolering. Samtidigt har behovet synliggjorts av ökad kunskap, rättvis vård och bättre behandling.
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Andersson, Daniel, and Emma Hellmark. "Arbetsterapeutens roll för personer med diagnosen myalgisk encefalomyelit/kroniskt trötthetssyndrom : En litteraturöversikt." Thesis, Luleå tekniska universitet, Institutionen för hälsovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-79099.
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Bakgrund: ME/CFS är en allvarlig, kronisk och komplex multisystemsjukdom som ofta och dramatiskt begränsar de drabbade personernas aktivitet. De vetenskapliga beläggen gällande effekten av interventioner riktade mot funktion och funktionsnedsättning är begränsade. Nuvarande kunskapsläge indikerar att arbetsterapeuten kan bidra i vården av personer med ME/CFS, men behov av vidare forskning finns. Syfte: Att med denna litteraturöversikt kartlägga och beskriva aktuell forskning gällande arbetsterapeutens roll för personer med diagnosen ME/CFS. Metod: Datainsamling för litteraturöversikten genomfördes baserat på utarbetade urvalskriterier i tre relevanta databaser; PubMed, CINAHL och PsycINFO och resulterade i tio artiklar, sju kvantitativa och tre kvalitativa studier. Studiernas kvalitet granskades och sedan utfördes en latent innehållsanalys. Resultat: Analysen resulterade i fyra kategorier: Att ge klientcentrerat stöd för strategier i aktivitet, Att justera terapeutiskt förhållningssätt vid aktivitetsanpassning, Att beakta gruppbehandlingens terapeutiska värde samt Att bidra till professionernas teamsamverkan. Slutsats: Arbetsterapeutens kompetens är ett viktigt bidrag i rehabiliteringen på grund av den komplexa aktivitetssituation som diagnosen innebär.Background: ME/CFS is a serious, chronic and complex systemic disease which often and dramatically limits the activity of the affected. The existing scientific evidence of interventions regarding function and disability is limited. The current level of knowledge indicates that the occupational therapist can contribute to the care for people with ME/CFS, but there is a need for further research. Aim: The aim of this literature overview was to map out and describe current research regarding the role of the occupational therapist for people diagnosed with ME/CFS. Method: Data collection for the literature overview was conducted based on developed selection criterias in three relevant databases; PubMed, CINAHL and PsycINFO which resulted in ten articles, seven quantitative and three qualitative studies. The quality of the included studies were assessed and finally a latent content analysis was completed which resulted in four categories. Result: The content analysis resulted in four categories: to supply a client centered support for strategies in activity, to adjust therapeutic approach in occupational adaptation, to consider the therapeutic value of the group treatment, and to contribute to the professional team collaboration. Conclusion: The expertise of the occupational therapist is an important contribution to rehabilitation due to the complex occupational situation for people diagnosed with ME/CFS.
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Wolfe, Patricia Jean de. "I'm really ill, I've got M.E. : bodily disorder and the quest for disease." Thesis, Goldsmiths College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298292.
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De, Wolfe Patricia Jean. "'I'm really ill, I've got M.E.' : bodily disorder and the quest for the disease." Thesis, Goldsmiths College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287740.
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Horton-Salway, Mary. "Mind and body in the discursive construction of M.E.: a struggle for authorship of an illness." Thesis, Loughborough University, 1998. https://dspace.lboro.ac.uk/2134/6982.
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This thesis is an analysis of the discursive construction of a controversial medical condition (Myalgic Encephalomyelitis) and how it has been made sense of, in and through the discourse of medical scientists, general practitioners, and M E sufferers. Various kinds of text and talk are analysed from the perspective of discursive psychology, arguing that versions of reality are a product of participants' constructive and dialogical practices. (I include my own text as an example of this.) The analysis of scientific texts, illness narratives, diagnostic narratives, and M E self-help group discussions, show how explanations about the status of M E and its causes are embedded in accounts of the identity of sufferers, the nature and status of medical explanation, and the competencies of medical practitioners. There is a sense in which the controversial topic of this thesis provides an ideal forum for examining both lay and professional reasoning practices about illness, in a context where the 'objective' world of 'medical facts' threatens to disintegrate into merely subjective points of view. One of my concerns has been to show how the participants themselves orient to, and manage this 'reality disjuncture' by means of a variety of discursive devices. The main body of the thesis addresses this problem through issues such as: the significance of diagnostic labels, different models of medicine, and the relevance of mind and body in explanations for illness. Finally, there is an analysis of the narrative constructions of M E sufferers and GPs, to show how psychosocial 'evidence' is used to warrant the speaker's interpretation of illness as either a mental or physical phenomenon.
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Procter, Charlotte Anne. "The post-viral fatigue syndrome." Thesis, Durham University, 1990. http://etheses.dur.ac.uk/6221/.
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Post-viral fatigue syndrome (myalgic encephalomyelitis) is a physically debilitating disorder associated with chronic disabling fatigue. This thesis presents two studies which look at the impact of illness from a personal-psychological and from a family perspective. The first investigates the psychological features of the syndrome. The prevalence of psychiatric disorder in 20 patients with the PVFS was determined. Sixty percent satisfied criteria for a current psychiatric disorder. Diagnoses were of neurotic depression and other neuroses. Only 25 % of a comparatively disabled group of 20 arthritis sufferers received similar diagnoses. Diagnoses did not substantially differ in type from a group of 20 subjects with major depressive disorders, although selected differences in symptom profile and the role of previous life-time psychiatric episodes, suggest that the PVFS cannot be regarded as a variant form of depressive disorder. A logistic regression analysis achieved a satisfactory separation of the two disorders on the basis of psychiatric symptoms. The second study investigates 9 school-aged children with mothers suffering from the syndrome, and 9 children with healthy parents. The children in the PVFS group had been exposed to their mother's illness from between 18 months and 14 years. They were found to have significantly more problems in the school environment in comparison to controls, rated as more shy and anxious, less assertive and with more relationship problems with peers. General family orientation was less active with fewer out-of-home family pursuits. Family interactions were somewhat more negative. Child adjustment is discussed in terms of the linkages between family, school and peer-group in the lives of these children. Investigations into the adaptive potential of such linkages and the permeability of the boundaries between the spheres raise important questions for ameliorative work in the counselling of PVFS sufferers and their families.
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DAREYS, BERNARD. "Le syndrome eosinophilie - myalgies par absorption de l-tryptophane : a propos de deux observations." Toulouse 3, 1991. http://www.theses.fr/1991TOU31033.
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RODOT, SYLVIE. "Le syndrome eosinophilie-myalgie lie au l-tryptophane : a propos d'un cas et revue de la litterature." Nice, 1991. http://www.theses.fr/1991NICE6821.
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Arnell, Erika, and Lena Höjskeld. "Diagnosen få känner till : Erfarenheter av Myalgisk encefalomyelit/kroniskt trötthetssyndrom." Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-33801.
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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) är en komplex sjukdom av okänd etologi. ME/CFS syns inte på utsidan men leder till funktionsnedsättning i varierande grad. Okunskapen om sjukdomen är stor vilket leder till att många får diagnos i ett sent skede eller en felaktig diagnos. ME/CFS innebär en etisk utmaning för forskningen, samhället och inte minst för sjukvården, då evidens för både omvårdnad och behandling fortfarande saknas. Syftet var att undersöka personers erfarenheter av att leva med ME/CFS. I databearbetningen framkom tre kategorier: möte med vården, påverkan på vardagen samt anpassning till livssituationen. I resultatet påvisas erfarenheter från personer med ME/CFS och hur de upplever bemötandet med vården och den okunskap som råder. Det framkommer att sjukdomen påverkar identitet, relationer och aktivitetsförmåga. Resultatet visar även hur livet förändras samt vilka strategier som krävs för att hantera vardagen när förutsättningarna i livet förändras. För att möta omvårdnadsbehovet hos personer med ME/CFS krävs mer forskning och utbildning för vårdpersonal.Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease of unknown etiology. Although ME/CFS is not visible on the outside, it leads to disability in varying degrees. There is a lack of knowledge regarding the disease, which often leads to a delayed or incorrect diagnosis. ME/CFS represents an ethical challenge for research, society and especially for healthcare professionals since no evidence-based nursing or treatment are available. The aim was to investigate people’s experiences with ME/CFS. Three categories emerged in the data analysis: meeting with the health care, impact on daily life and adaption to the new life situation. The result shows experiences of people with ME/CFS and how they feel they are treated by the healthcare system and the lack of knowledge that exists. It appears that the disease affects identity, relationships and abilities in physical activity. The result also shows how life changes and what strategies are required to manage everyday life when the conditions in life change. To meet the nursing needs of people with ME/CFS, more research on the subject, as well as education for healthcare professionals, are necessary.
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McGregor, Neil Roland. "An Investigation Of The Association Between Toxin-Producing Staphylococcus Biochemical Changes And Jaw Muscle Pain." University of Sydney, 1999. http://hdl.handle.net/2123/4697.
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Doctor of PhilosophyThis work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au
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Ramsden, Rebecca Mary. "Narratives of partners of individuals affected by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17195.
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Background and Aims: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) remains a poorly understood condition, shrouded in uncertainty and dispute. Research suggests this context to have a profound bearing on those touched by the condition, impacting significantly on their experience and the narratives constructed thereof. However, no studies examining the narratives of partners of individuals affected by CFS/ME appear to have been carried out to date. Based upon this gap in the literature, this study sought to hear the narratives of partners of adults living with CFS/ME, giving particular consideration to the ways in which these narratives were told to an outsider, and how the outsider may have influenced the narrative. Methodology: This study drew on a qualitative approach. A purposive sample of six partners of adults affected by CFS/ME (4 men and 2 women) was recruited. Individual interviews were conducted that were audio-recorded and transcribed. Narrative analysis was used to analyse the transcripts, focusing principally on how participants narrated their accounts, as well as on the content of narratives and the narrative and discursive features that shaped the telling of the accounts. Analysis and Findings: Multiple readings of the narratives identified two areas of collective focus within participants' accounts - 'stories from then' and 'stories from now'. Some similarities in how 'stories from now' were told were seen to emerge down gender lines. Notably participants' storytelling could be seen to represent a form of response to wider narratives that purvey around CFS/ME, with participants' being observed to construct particular meanings around CFS/ME, as well as particular 'identities' of themselves, their partner, their relationship and 'others' who had played a key role in their story of living with the condition. The findings are discussed in terms of their potential bearing for clinical practice and future research endeavours. In addition, the strengths and the limitations of the research are considered.
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Jaffray, Penny. "Society, the body and pain : sociological factors in assessing the meaning and experience of pain in myalgic encephalomyelitis ("yuppie flu") sufferers." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1008381.
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This thesis explores the meaning and experience of the bodily states associated with the condition referred to as myalgic encephalomyelitis (ME). It uses as a theoretical point of departure an understanding of the body as a socially constructed phenomenon and, in so dOing, offers an interpretation of illness that is seen to differ markedly from those offered by the medical and behavioural sciences. Using descriptive narrative research analysis, the thesis attempts to elicit personal trajectories of illness experience. In contrast to biomedical and social trajectories of illness, in which the interpretation and meaning given to the condition are imposed externally, personal trajectories are seen to provide unique subjective accounts of illness experience. And the value of using narrative accounts of illness is seen to lie in their ability to bring to light these individualised versions of illness experience. It is shown, in addition, that these narrative accounts of illness are also valuable in exposing the culturally shared knowledge that is employed in the process of assigning meaning to illness experiences. The aim of the thesis, then, in employing the descriptive narrative research method is to describe these shared cultural schemas. It is suggested that this approach leads to an interpretation of illness experience which sheds light on important links between the body, self and society. It is argued, more specifically, that Western capitalist society is associated with the creation of an "unnatural" environment and social context which is perceived to be inherently damaging and threatening to the well·being of those living in it; and that this assumption is pivotal to the interpretation of the illness experiences narrated and analysed for the thesis. This sociological reading of embodiment provides a basis for understanding the experience of illness, as not one simply embedded in the body or mind of the individual, but as one laden with personal meaning assimilated from, and hence revealing of, the social context in which the illness is experienced. As such, an attempt is made to provide an account of illness experience distinct from the dominant biomedical and behavioural accounts of ME.
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Lecomte, Jacqueline. "Effect of Naproxen on delayed onset muscle soreness." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35213.
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The purpose was to determine the effect of Naproxen in attenuating the symptoms (muscle soreness level) and signs (plasma CK activity and muscular strength decrement) of delayed onset muscle soreness (DOMS). Twenty subjects were randomly assigned Naproxen (500 mg BID) or placebo in a double-blind, crossover design. Two testing phases, each 8 days in duration, were separated by a washout period of 7 days. Eccentric single-leg exercises were performed on Days 1, 3 and 4 to induce DOMS in the quadriceps muscles. Perception of muscle soreness, plasma CK, and knee extensor torque were evaluated throughout each phase. Following the eccentric exercise, plasma CK levels were similarly elevated in both Naproxen and placebo conditions. After DOMS had developed, Naproxen reduced the perception of soreness on Day 3 when muscle soreness was highest. Following treatments with Naproxen, peak quadriceps torque during leg extension at 60$ sp circ$/s was higher compared to placebo, however at higher velocity (180 and 300$ sp circ$/s) peak muscle torques were similar. The data indicate that therapeutic doses of Naproxen do not prevent CK release into the plasma but decreases the perception of muscle soreness and positively influences quadriceps peak torque.
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Overdiek, Ronda Michele. "A comparison of the incidence and degree of postoperative myalgia and muscle fasciculations associated with dose and duration of succinylcholine administration /." Full Text (HTML) Full Text (PDF) Abstract, 2008. http://eprints.ccsu.edu/archive/00000500/02/1956FT.htm.
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Thesis (M.S.) -- Central Connecticut State University, 2008.Thesis advisor: Ruth Rollin. "... in partial fulfillment of the requirements for the degree of Master of Science in Biological Sciences: Anesthesia." Includes bibliographical references (leaves 73-86). Also available via the World Wide Web.
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Reinöhl, Jochen. "Adenosintriphosphat und Capsaicin als Auslöser von Muskelschmerz eine Untersuchung an mechanosensitiven Gruppe-IV-Muskelafferenzen der Ratte." Saarbrücken VDM Verlag Dr. Müller, 2006. http://d-nb.info/99125841X/04.
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Kopec, Thomas John. "Effects of two therapeutic modalities on acute muscle soreness." Akron, OH : University of Akron, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1239982059.
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Thesis (M.S.)--University of Akron, Dept. of Sport Science and Wellness Education, 2009."May, 2009." Title from electronic thesis title page (viewed 8/3/2009) Advisor, Ronald Otterstetter; Committee members, Stacey Buser, Carrie Fister; Department Chair, Victor Pinheiro; Interim Dean of the College, Cynthia Capers; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
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RIGAULT, SCHWEITZER MARIE-LAURE. "Fasciite avec eosinophilie et maladies apparentees." Angers, 1993. http://www.theses.fr/1993ANGE1041.
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Goudsmit, Ellen Marianne. "The psychological aspects and management of chronic fatigue syndrome." Thesis, Brunel University, 1996. http://bura.brunel.ac.uk/handle/2438/4283.
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Chronic fatigue syndrome (CFS) describes a condition characterised by severe fatigue of at least six months' duration. In this thesis, it is argued that the complexity of CFS with respect to other symptoms, the patients' response to their illness and the determinants of emotional distress, has yet to be fully recognised. This may have narrowed the focus of research and limited the range of treatments available. The first of the three studies investigated CFS from the patients' perspective. The findings challenge some of the generalisations concerning CFS, particularly those relating to the patients' attributions and their choice of coping strategies. They also suggest that the effects of the condition may have been underestimated and that certain influences on emotional distress may have been overlooked. The second study assessed a number of variables thought to be associated with emotional distress and psychological adjustment. The results show that uncertainty and lack of social support were significantly correlated with anxiety and depression while functional impairment was more closely linked to cognitive difficulties and other illness-related measures. The third study evaluated a management programme which acknowledges the complexity of CFS. After six months, significant differences between the treated patients and waiting-list controls were found for a number of variables, including fatigue, somatic symptoms, anxiety and perceived self-efficacy. However, many patients continued to record high levels of emotional distress, showing that the programme was not sufficient to deal with all the problems experienced.
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Jerner, Adéle, and Lina Svedberg. "The Effect of Topical Anesthesia on Pain Perception in Patients with Local Myalgia." Thesis, Umeå universitet, Tandläkarutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97853.
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Temporomandibular disorders (TMD) is a term used to embrace pain and dysfunction in the jaw-, face- and temple region. Myofascial pain is considered the most common condition included in TMD. The diagnostic criteria for myalgia are based on the patient’s symptoms and clinical signs, where pain to palpation of the jaw muscles is vital. The aim of this experimental trial was to examine whether pain perception is influenced by topical anesthesia in patients with local myalgia of the jaw muscles. Our hypothesis was that the pressure pain thresholds (PPT) at jaw muscle sites are affected after topical application of anesthesia in patients with local myalgia. Ten women (median age 36 years) with TMD related to myalgia participated in the study. The PPT at masseter muscle and temporal muscle sites bilaterally and the first dorsal intraossei on the dominant hand were measured using an electronic algometer. After a baseline registration, EMLA or placebo cream was applied on the chosen sites in a randomized order. A new registration was carried out five minutes after the application. The values for each participant before and after the application were compared using Wilcoxon rank sum test. A P-value < 0.05 was considered statistically significant. The PPT increased significantly after application of topical anesthesia, but not placebo cream. The results indicate that the superficial nociceptors were sensitized and sensitive to topical anesthesia in patients with TMD related to myalgia. The interpretation of a pain response to pressure thus seems to be complex and warrant further studies.
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Barcroft, Rachel. "Chronic fatigue syndrome/myalgic encephalomyelitis and fibromyalgia : a social model of disability perspective." Thesis, Lancaster University, 2017. http://eprints.lancs.ac.uk/87165/.
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This thesis is composed firstly of a literature review focusing on the attitudes of health professionals towards chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and fibromyalgia. Secondly, a research paper explores the ways in which people living with CFS/ME have experienced psycho-emotional disablism. Finally, a critical appraisal discusses the process of conducting the research as well as its strengths and limitations. The literature review takes the form of a meta-synthesis regarding the attitudes of healthcare professionals towards CFS/ME and fibromyalgia. A meta-ethnographic approach was used with reciprocal translation producing the following themes: “Feeling hopeless and more hopeless”: psychological effects of lack of knowledge; “Your heart sinks when they come in the room”: stigma and stereotypes; and “I’m going to be with you through thick and thin”: management of the condition. The review highlights the difficulties faced by health professionals regarding the management and diagnosis of both conditions, as well as possible reasons for the negative attitudes held by some professionals. The research paper, which employed thematic analysis, explores the ways in which people living with CFS/ME have experienced psycho-emotional disablism. Three overarching themes were identified: “fighting to be heard”; “lack of legitimacy” and “feeling invisible”. Participants described the discrimination and stigma that they had encountered from many areas of society. Ideas for future research are proposed. The critical appraisal presents the author’s reflections on the research process as well as its strengths and limitations, and the five stages of the process are described as follows: choosing a thesis topic and designing the project; recruitment and research interviews; the interview process; analysis and writing up of the data; and the author’s reflections on the project.
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Kaiser, Jennifer L. "The effects of polyunsaturated phosphatidylcholine supplementation on body composition and muscle recovery from repeated bouts of resistance exercise." Virtual Press, 2002. http://liblink.bsu.edu/uhtbin/catkey/1231346.
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The purpose of this study was to examine the influence of a supplement containing polyunsaturated phoshphatidylcholine (PPC) on physical performance, delayed muscle soreness (DOMS), markers of membrane damage, and lipid peroxidation after repeated bouts of whole body resistance on men ages 18-35 years. Subjects were randomly assigned to receive either PPC or placebo supplements for 31 days. After 3 weeks of supplementation, subjects were to perform 3 whole body resistance exercise sessions with 3 days of recovery between sessions. In order to document the effects of supplementation on recovery, fasting blood samples for determination of creatine kinase (CK) and malondialdehyde (MDA), and muscle soreness ratings were obtained each day in the morning after the initial 3 weeks of supplementation. The data was analyzed using a two-way ANOVA. The results indicate notable trends favoring PPC supplementation, such as lower ratings of perceived muscle soreness, lower CK and MDA responses to repeated bouts, improved maintenance of upper body strength and power, and increased lean body mass. However, these findings were not statistically different when compared to the placebo group.School of Physical Education
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Zennaro, Daniel Zennaro Daniel Heiko. "Analysis and interpretation of long-term intramuscular electromyography signals during prolonged computer work /." [S.l.] : [s.n.], 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=14897.
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Hedenberg-Magnusson, Britt. "Masseter muscle pain and its relation to pain mediators in fibromyalgia and local myalgia /." Stockholm : [Karolinska institutets bibl.], 2001. http://diss.kib.ki.se/2001/91-7349-038-5/.
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Payne, Rosalind. "Narratives of parents living with a child affected by chronic fatigue syndrome/myalgic encephalomyelitis." Thesis, University of Hertfordshire, 2017. http://hdl.handle.net/2299/17472.
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Background and Aims: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) remains a poorly understood condition, shrouded by debate, stigma, and uncertainty. Unsurprisingly, the little available research suggests that caring for a Child or Young Person (CYP) affected by the condition can be extremely challenging. While the majority of available literature is quantitative in nature, there is some qualitative research examining the impact of having a CYP with CFS/ME on parents. However, there currently appear to be no studies examining the narratives of parents living with a CYP with CFS/ME. Therefore, this research aimed to hear how parents narrate their experiences of living with a CYP affected by CFS/ME, paying attention to how they construct their identity, and the contested condition. Methodology: This research drew on a qualitative approach that explored the narratives of the participants. A purposive sample of five parents of CYP affected by CFS/ME (5 mothers) was recruited for a single semi-structured interview. The interviews were audio-recorded, transcribed, and analysed using a narrative approach to explore what participants said and how they narrated their accounts. This was then situated within the social and cultural contexts that shaped them. Analysis and Findings: Multiple readings of the narratives allowed me to develop a summary of each individual's narrative account. These were presented, after which similarities and differences across narratives were considered. Analysis identified six areas of collective focus: 'stories of onset and diagnosis', 'stories of battle', 'stories of finding the person/people who can help', 'stories of impact', 'stories of seeking social support', and 'stories of coping and adjustment'. Participants' narratives were heavily influenced by dominant societal discourses surrounding CFS/ME and motherhood, and could be seen as a response to these narratives. Consequently, participants offered particular constructions of the condition, themselves, their CYP, and others that they had come into contact with. These findings are discussed with reference to their potential bearing for clinical practice, strengths and limitations of the methodology, and directions for future research.
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McKay, Pamela Gair. "An exploratory study into the symptoms of chronic fatigue syndrome/myalgic encephalomyelitis and fibromyalgia." Thesis, University of the West of Scotland, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738487.
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Stalmeisters, Dzintra. "An investigation into the relationship between early maladaptive schemas and myalgic encephalomyelitis/chronic fatigue syndrome." Thesis, University of Derby, 2012. http://hdl.handle.net/10545/312811.
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The aim of the research was to investigate the relationship between early maladaptive schemas, as described by Young, Klosko and Weishaar (2003), and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Despite the recognition of characteristics associated with these schemas in people with ME/CFS by clinicians, a review of the literature suggests that systematic research into this relationship has not previously been conducted. This thesis progresses knowledge in this area by providing a schema-level understanding of ME/CFS and offering insights into the behavioural process involved in the progression from schema to illness. The research employed mixed methods enabling a consideration of the relationship from different perspectives, and is grounded in a critical realist perspective. The quantitative study involved 40 people with ME/CFS and 40 people from a non- clinical population who completed Young's Schema Questionnaire (YSQ-S3), a questionnaire designed to elicit 18 early maladaptive schemas. The schemas Unrelenting Standards and Self-Sacrifice were the most prevalent in both groups. Unrelenting Standards was endorsed by 47.5% of the ME/CFS group and by 25% of the non-clinical group at a level of' clinical caseness', whilst the percentage of people that endorsed the Self-Sacrifice schema was similar in each group; 27.5% of the ME/CFS group endorsed this schema and 25% of the non-clinical group. There were significant correlations between the schemas Unrelenting Standards and Self- Sacrifice; age and the schema Social Isolation; qualifications and the schema Self- Sacrifice also current employment and the schema Unrelenting Standards. The qualitative study, which involved 13 people with ME/CFS, adopted a Grounded Theory approach influenced mainly by the works of Glaser, (1978, 1998, 2011) and Charmaz (1995, 2007). The core category generated from the data was termed 'obscuring', and conceptualised the manner in which early maladaptive schemas and the coping style 'surrender to the schema' obscured the needs of individuals with throughout the therapeutic process. The number of early maladaptive schemas reduced once depression had been treated, whilst the schemas Unrelenting Standards and Self-sacrifice remained at a level of 'clinical caseness' at the end of therapy, although their scores on Young et al. 's Schema Questionnaire (YSQ S-3) had decreased. The qualitative study and case study gave an insight into the complexity of early maladaptive schemas in relation to the illness, giving real life meaning to the quantitative findings and together the three studies increased the credibility of the theory that emerged from the qualitative analysis. Taken together the studies have implications for the Cognitive Behavioural model of ME/CFS (Surawy et al. 1995). It is proposed that early maladaptive schemas have relevance for the model at the predisposing and perpetuating levels; that the theoretical codes 'compelling', 'curtailing' and 'compassionating', derived from the grounded theory analysis, are evident at these levels; and that the model might benefit from the inclusion of the terms 'unhelpful emotional responses' and 'psychological rewards'. The research not only supports clinical observations, but also contributes to cognitive and behavioural theory and therapeutic interventions for ME/CFS, helping to deepen understanding of the role that early maladaptive schemas have in this disabling and unpredictable illness. Recommendations are made for clinical practice and future research.
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Osoba, Tolu. "The development of an epidemiological case definition for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)." Thesis, University of the West of England, Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444489.
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Whitehead, Lisa. "The lived experience of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) : sufferers' and families' perspectives." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406661.
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Williams, Deborah Samantha. "Long-term experiences of managing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) : a qualitative study." Thesis, University of the West of England, Bristol, 2016. http://eprints.uwe.ac.uk/28310/.
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Background: Frustrations are noted in the management of CFS/ME as it’s a complex and individual condition with no known cure. Despite being a Long-term Condition (LTC) limited research has focused on long-term experiences. This study aims to extend the knowledge of long-term experiences of CFS/ME specifically focusing on management of the condition. Thinking about therapeutic moderators and mechanisms of change, whether management changes throughout the course of the illness and what support people might benefit from. Methods: A qualitative research design, using semi-structured interviews was adopted. Nine participants' were recruited from a specialist CFS/ME Service in the UK who were over 18 years old, had a diagnosis of CFS/ME and reported experiencing fatigue related symptoms for over 5 years. Interviews were audio recorded, transcribed verbatim and analysed using Thematic Analysis. Findings: Three themes; Awareness, Acceptance, Connection and two subthemes; connection with self and connection with others were constructed from the data. An overarching theme of Awareness appeared to facilitate the ability to accept and connect with what was important for people with CFS/ME, enabling people to adapt to living with the condition and achieving a standard of living. Commonalities occurred across all themes of development over time, individuality and ongoing balance or monitoring. Discussion: Findings suggest supporting adults with CFS/ME to become more self-aware of their illness experience and identifying their values will be beneficial at any stage of the illness duration, but particularly important for long-term management. These findings provide further support for tailored treatment plans (NICE, 2007) with some individuals' needing more, or occasional contact with understanding professionals to achieve. The results support the use of acceptance-based interventions in LTC management; specifically Acceptance and Commitment Therapy (ACT) and Focused ACT. Further research into outcomes and experiences of ACT in CFS/ME, and interdisciplinary approaches is advocated.
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Crisp, Catrina C. M. D. "Intra-vaginal Diazepam for High Tone Pelvic Floor Dysfunction: A Randomized Placebo-Controlled Trial." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367926075.
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Spencer, Patricia E. "From morphine to milk of magnesia : a case study of children and families living with M.E." Thesis, University of East Anglia, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338040.
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Bodéré, Céline. "Hyperactivité musculaire dans les douleurs myofasciales orofaciales." Clermont-Ferrand 1, 2007. http://www.theses.fr/2007CLF1DD01.
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Bien que très fréquente, la douleur musculaire chronique reste mal comprise. Les deux travaux présentés dans ce mémoire portent sur l'étude électrophysiologique des muscles masticateurs chez les patients souffrant de douleurs orofaciales chroniques (myofasciales et neuropathiques) et chez des sujets non-douloureux (dérengements internes de l'articulation temporo-mandibulaire et contrôles). La première étude évalue la relation entre une douleur orofaciale spontanée chronique, modérée ou sévère, et deux variables électrophysiologiques : l'activité électromyographique (EMG) au repos et l'amplitude du réflexe massétérin. En présence de douleurs orofaciales, myofasciales ou neuropathiques, les muscles temporaux et masséters présentent une "hyperactivité EMG" tonique et une réduction majeure de l'amplitude du réflexe massétérin. Quand les douleurs sont unilatérales, ces signes sont identiques du côté douloureux et non douloureux. Nous en déduisons que la modulation de l'activité musculaire en présence de douleurs orofaciales chroniques n'est pas la conséquence directe d'un mécanisme nociceptif périphérique et nous discutons l'hypothèse d'un mécanisme d'origine central. La seconde étude montre en l'effet d'une butée antérieur (JIG) sur cette "hyperactivité" EMG : le JIG réduit transitoirement l'activité EMG des muscles masticateurs dans les douleurs myofasciales mais pas dans les douleurs neuropathique. Si le premier travail suggère que la douleur myofasciale pourrait être une "douleur neuropathique du muscle" le second montre que les deux entités pathologiques diffèrent sur certains mécanismes. Par ailleurs, la seconde étude confirme l'intérêt de l'utilisation transitoire du JIG en pratique odontologique (rapports intermaxillaires, ajustements occlusaux). Ce travail ouvre sur deux projets en cours d'inclusion. La première étude, exploratoire, fait l'objet d'un Projet Hospitalier de Recherche Clinique régional, la seconde est un essai thérapeutique non pharmacologiqueAlthough very common, the chronic muscle pain remains badly understood. This memory presents two electrophysiological studies of masticatory muscles in orofacial chronic pain patients (myofascial and neuropathic) and in not-painful subjects (temporo-mandibular joint disorders and controls). The first study evaluates the relation between moderate to severe chronic orofacial spontaneous pain and two electrophysiological variables : the electromyographic activity (EMG) at rest and the jaw-jerk reflex amplitude. The temporal and masseter muscles display a tonic EMG "hyperactivity" and a strong reduction of the jaw jerk reflex amplitude in both myofascial and neuropathic orofacial chronic pain patients. These signs are identical in pain and non-pain sides in unilateral-pain patients. We deduct that EMG activity modulation in orofacial pain patients is not the direct consequence of a peripheral nociceptive mechanism and we explain why it could be of central origin. The second study shows the effect of an anterior bite stop (JIG) on this tonic EMG "hyperactivity" : the JIG reduce temporarily the EMG activity in myofascial pain patients not in neuropathic ones. If the first study suggests that myofacial pain could be a "neuropathic pain in the muscle", the second shows that the two pathologies differ on certain mechanisms. However, the second study supports the use of the JIG in certain short-term clinical approaches (recording of centric relation closures and for occlusal adjustement). These woks lead on to two projects on chronic muscular pain in the process of inclusion. The first project is exploratory ; the second is a non-pharmacological therapeutic trial
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Féasson, Léonard. "Les protéines de structure musculaires et leur adaptation aux contraintes mécaniques de l'exercice : relations avec les courbatures." Saint-Etienne, 2004. http://www.theses.fr/2004STET009T.
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Les protéines de structure du muscle strié squelettique sont organisées en réseaux rigoureusement agencés permettant par leur mise en jeu coordonnée, la genèse du mouvement et de la force musculaire. L'exercice inhabituel ou intense, en particulier lorsqu'il est réalisé avec une forte composante excentrique, engendre des " courbatures " associées à de nombreux remaniements de l'architecture moléculaire musculaire. Ce phénomène conduit à des lésions tissulaires puis secondairement à un remodelage myofibrillaire assimilé à une réponse adaptative protectrice. A partir d'études cliniques et physiologiques intégratives, d'analyses ultra structurales, biochimiques et moléculaires, nous avons évalué les effets mécaniques de l'exercice sur des muscles humains ayant subit le phénomène des courbatures ou un entraînement à l'endurance. Nous avons plus particulièrement orienté notre étude sur les protéines impliquées dans les maladies neuromusculaires. Nos résultats sont présentés en confrontation aux données de la littérature. Ils rapportent des modifications fonctionnelles et tissulaires et suggèrent un remodelage moléculaire pouvant s'inscrire dans les plus récentes théories de l'adaptation protectrice du muscle à l'exercice.
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CACHERA, MOLINIER ISABELLE, and PHILIPPE CACHERA. "Syndrome eosinophilie-myalgies induit par la prise de l. Tryptophane : a propos d'une observation." Lille 2, 1991. http://www.theses.fr/1991LIL2M339.
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Lynch, Sean Patrick Jeremy. "The nature of fatigue in the chronic fatigue syndrome : a longitudinal study." Thesis, Imperial College London, 1996. http://hdl.handle.net/10044/1/7496.
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Dardani, Vedije, Sara Lindgren, and Evelina Svensson. ""Vad jag än gör så kostar det..." : Upplevelsen och erfarenheten av ansträngningsutlöst försämring hos personer med Myalgisk Encefalomyelit/Kroniskt Trötthetssyndrom: En empirisk studie baserad på bloggar." Thesis, Jönköping University, HHJ, Avd. för omvårdnad, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-51587.
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Inledning: Myalgisk encefalomyelit/kroniskt trötthetssyndrom (ME/CFS) kännetecknas som en inflammation i hjärna och ryggmärg och karakteriseras framför allt av ihållande utmattning. Sjukdomen är ingen kultursjukdom eller lokal företeelse utan den förekommer i diverse åldrar, länder och sociala grupper. Ansträngningsutlöst försämring (PEM) är ett kardinalsymtom för sjukdomen. PEM kännetecknas av en förvärring av symtom efter rörelse, ortostatisk eller neuromuskulär stress och/eller kognitiv aktivitet. Syfte: Syftet var att beskriva upplevelsen och erfarenheten av ansträngningsutlöst försämring (PEM) hos personer med ME/CFS. Metod: En kvalitativ empirisk studie baserad på bloggar med deduktiv ansats. Livsvärldsteorin användes som en teoretisk referensram. Resultat: Resultatet visade att personer med ME/CFS beskrev PEM som en påfrestande och dramatisk upplevelse och att det krävdes ständiga anpassningar för att undvika försämringen. Situationen förvärrades ytterligare av ett bristfälligt och empatilöst bemötande inom sjukvården. Slutsats: På grund av känslighet för stimuli behöver varje handling gentemot personer med diagnosen ME/CFS reflekteras över huruvida den är till nytta eller till skada. För att förhindra PEM måste vården anpassas utifrån individuella ansträngningströsklar hos varje enskild person. Vidare forskning behövs om vilka förändringar som krävs för att säkerställa högkvalitativ omvårdnad.Introduction: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized as inflammation of the brain and spinal cord and is characterized above all by persistent fatigue. The disease ME/CFS is not a cultural disease or a local phenomenon and It occurs in various ages, countries and social groups. PEM is characterized by an exacerbation of symptoms after movement, orthostatic or neuromuscular stress and / or cognitive activity. Purpose: The aim of this study was to describe the experiences and the perceptions of post-exertional malaise (PEM) in people with ME/CFS. Method: The study was a qualitative empirical study with a deductive approach based on blogs. Lifeworld was used as a theoretical framework. Result: The results showed that people with ME / CFS described PEM as a stressful and dramatic experience and that constant adjustments were required to avoid this deterioration. The situation was further aggravated by a deficient and unempathetic response in healthcare. Conclusion: Due to abnormal sensitivity to stimuli, each intervention for persons diagnosed with ME / CFS needs to be reflected on whether it is beneficial or harmful. To prevent PEM, healthcare must be adjusted based on the individual effort thresholds of each person. Further research is needed on what improvements are required to ensure high-quality nursing.
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Hadrévi, Jenny. "Applying proteomics and metabolomics for studying human skeletal muscle with a focus on chronic trapezius myalgia." Doctoral thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61399.
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Work related musculoskeletal disorders are the dominating causes of reported ill-health in industrialized countries. These chronic pain conditions are one of the most costly public health problems in Europe and North America. When work related musculoskeletal disorders are considered to be of muscular origin and the trapezius muscle is affected, the common appellation is trapezius myalgia. Since little is known about the genesis or how it is maintained, it is of great importance to better understand the pathophysiology of trapezius myalgia; doing so will better enable recommendations for prevention, treatment and rehabilitation. Several hypotheses have been presented based on biochemical alterations in the muscle, suggesting increased signaling of inflammatory substances and altered metabolism. Previous research has not been able to present the comprehensive picture of the muscle in pain. Thus there is a demand for more comprehensive research regarding the biochemical milleu of the chronic trapezius muscle. Proteomic and metabolomic methods allow non-targeted simultaneous analyses of a large number of proteins and metabolites. The main emphasis in this thesis is on a proteomic method, two-dimensional differential gel electrophoresis (2D-DIGE). The method is validated to human skeletal muscle biopsy research with laboratory specific settings. In the baseline study, there were 14 metabolic, contractile, structural and regulatory proteins that differed significantly in abundance when trapezius and vastus lateralis muscles were compared. Using the validated 2D-DIGE method and the baseline study, a comparison between healthy and myalgic muscles was made. Biopsies from female cleaners with and without myalgia were compared to obtain results from women with the same type of work exposure. In the multivariate model, 28 identified unique proteins separated healthy and myalgic muscle and were grouped according to function: metabolic (n=10), contractile (n=9), regulatory (n=3), structural (n=4), and other (n=2). Finally, a second screening method, metabolomics, was introduced to analyze differences in metabolite content as a complement to and verification of the proteomic results. Gas chromatography-mass spectrometry (GC-MS) was performed on muscle interstitial fluid samples obtained with microdialysis, and differences in the abundance of extracellular metabolites were revealed. The 2D-DIGE method is a reliable method to analyze human skeletal muscle. The outcomes of the proteomic analyses were dependant on the statistical approach. Systematic differences in protein and metabolite content were detected using a multivariate approach. Univariate analyses were used to analyze individual proteins for their significance. The significant proteins in the baseline study were predominately related to muscle fiber type which correlated with the differences in fiber type content between trapezius and vastus lateralis. The proteomic and metabolomics studies where myalgic and healthy muscles were compared provide us with new clues and new aspects regarding the pathophysiology of the myalgic muscle. Technically advanced methods employed in the thesis enabled an explorative screening of proteins of relevance for the pathophysiology of the myalgic muscle. The results of these analyses may contribute to the formulation of future hypothesis that need to be further evaluated.
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Solomons, Wendy. "Narratives of young people living with a diagnosis of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17597.
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CFS/ME (Chronic Fatigue Syndrome/Myalgic Encephalomyelitis) is a distressing and potentially debilitating condition. It can also be understood as a contested condition, surrounded by controversy about its nature, causes and treatment. Previous research indicates that those affected experience this climate of contestation as a troubling and discrediting assault, not only on the nature of their condition, but also on their identities. However, little attention has been paid to the voices of young people living with CFS/ME. This thesis extends a relatively small literature in new directions, focusing a constructionist, discursive narrative lens on the accounts of ten young people (aged 13-18) living with a diagnosis of CFS/ME. Narratives constructed during repeated interviews over a year, and drawing on multimodal materials collected by participants over that period, were analysed for their content, structure and performance, with reference to the local and broader contexts of their production. This analysis demonstrates that teenagers construct rich, multi-layered narratives with the potential to enhance understanding of their situation and broader features of the social world. As they speak of the onset of illness, attempts to live with enduring, unpredictable symptoms and their psychosocial consequences, and (for some) the possibility of 'moving on' from the worst of illness, this analysis throws new light on how young people's narratives can be understood as simultaneously constructing the condition ('M.E.') and the identities of those involved ('me' and others), in ways that engage with, reflect and resist prevailing discourses. It is argued that the discursive contexts of CFS/ME and adolescence raise particular challenges for young people as they try to construct credible narratives that convey the full extent of their difficulties, while resisting stigmatising identities (eg, as 'complaining', 'lazy' or otherwise 'not normal'). This analysis highlights implications for them, their families and those who work professionally with them; and for the ongoing social construction of CFS/ME in young people.
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Haig-Ferguson, A. "The impact of managing a child's chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) on family relationships." Thesis, University of the West of England, Bristol, 2014. http://eprints.uwe.ac.uk/23622/.
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Although there is a large body of research literature concerning the impact of childhood chronic illness on family relationships, very little of this has specifically focussed on the impact of childhood Chronic Fatigue Syndrome/Myalgic Encephalopathy (CFS/ME). The current study therefore aims to investigate the impact of having a child with CFS/ME on family relationships from the perspective of parents. This study takes a qualitative approach. Semi-structured interviews were used to explore 18 parents’ experiences of having a child with CFS/ME and the impact this has had on family relationships. Interview data were transcribed and analysed using thematic analysis. The analysis led to the identification of 5 main themes: “Long and Difficult Journey”, “Uncertainty”, “Isolation and Restriction”, “Focus on the unwell person at the expense of family life” and “Parental roles”. They felt that life had become a constant struggle and often felt exhausted. They felt uncertainty, isolation and restriction. These parents talked about feeling like family life had become focussed on their unwell child, such that some expressed a need to escape from the situation. They also described how, as a consequence of managing their child’s CFS/ME, family members could often feel marginalised and the illness could be seen as a destructive force. However, many parents also described working as a team and feeling that family relationships had benefitted in some way. The results of this study are in line with findings of other studies into other chronic illnesses. In addition, this is the first study to focus exclusively on the impact of CFS/ME on family relationships from the perspective of the parents, and is unique in that there is a dual focus on both mothers and fathers. Clinicians should be aware that parents of children with CFS/ME may need additional support, such as information as to what to expect at various stages of the illness and where to access the relevant support.
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Stråhle, Helena. "Autoimmuna aspekter i Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome : En litteraturstudie rörande indikationer på autoimmunitet i ME/CFS." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-96736.
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Bakgrund: Myalgic Encephalomyelitis eller Chronic Fatigue Syndrome (ME/CFS) omfattar ett spektrum av olika symptom som bland annat påverkar de autonoma och neurologiska systemen, kognitiv funktion och ger immunologiska störningar med mera. De karakteristiska symptomen är oförklarlig kronisk trötthet, ansträngningsutlöst fysisk och mental uttröttbarhet Post Exertional Malaise (PEM). Trots forskning inom ett flertal områden är den underliggande molekylära orsaken bakom ME/CFS inte fastställd. Flertalet hypoteser om sjukdomsorsaken finns, varav en är att ME/CFS är en autoimmun sjukdom. Syfte: Syftet med litteraturstudien är att undersöka huruvida det finns autoimmuna aspekter i ME/CFS. Metod: Systematisk litteraturstudie utifrån vetenskapliga artiklar, publicerade 2010—2020 i databasen PubMed. Resultat: Studieresultaten är inte helt entydiga när det kommer till att påvisa autoimmuna aspekter i ME/CFS. Antikroppsstudier riktade mot neuronalt protein hos ME/CFS-patienter och behandlingar riktade mot antikroppar, immunoadsorption och rituximab, gav negativa resultat. Däremot observeras HSP60 (heat shock protein 60) antikroppar för specifika korsreaktiva epitoper i en undergrupp av ME/CFS-patienter, vilket stämmer överens med infektionsutlöst autoimmunitet. Även i de två genstudierna, HLA-association (human leucocyte antigen) och SNP (single nucleotide polymorphism) genotypning i immungener, observeras karakteristiska riskgener för autoimmun sjukdom, tydligast resultat observerades hos de patienter som har en infektionsutlöst ME/CFS. Slutsats: Trots delvis negativa resultat ges visst stöd för hypotesen då dessa indikerar autoimmuna aspekter i en undergrupp av infektionsutlöst ME/CFS.Background: Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease which is characterized by unexplained and persistent post exertional fatigue (PEM) and a myriad of symptoms related to neurological disturbance, immunological, cognitive and autonomous dysfunction. Despite biomedical research from a disparate field of expertise the pathogenesis and etiology of ME/CFS is not well-understood. Several hypotheses regarding the pathogenesis have been proposed one of which is that ME/CFS is an autoimmune disease. Aim: The purpose of the literature study is to investigate whether there are autoimmune aspects in ME/CFS. Method: A systematic literature study based on scientific articles, published 2010-2020 in the PubMed database. Results: The study results are not entirely consistent when it comes to detecting autoimmune aspects in ME/CFS. Antibody studies targeting neuronal proteins in ME/CFS-patients and antibody treatments, immunoadsorption, and rituximab yielded negative results. In contrast, HSP60 (heat shock protein 60) antibodies for specific cross-reactive epitopes are observed in a subset of ME/CFS patients, which corresponds to infection-triggered autoimmunity. The two gene studies, HLA (human leucocyte antigen) association and genotyping of SNP (single nucleotide polymorphism) in immune genes, observed characteristic risk genes for autoimmune disease. Significant results were observed in ME/CFS- patients with an infection-triggered onset. Conclusion: Despite partially negative results, some support exists for the hypothesis as results indicate autoimmune aspects in ME/CFS with an infection-triggered onset.
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Parslow, Roxanne Morin. "Developing a patient reported outcome measure (PROM) for children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715797.
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Van, Tubbergh Karen. "Skeletal muscle repair after micro-damage : effect of ice therapy on satellite cell activation." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/16623.
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Thesis (MSc)--University of Stellenbosch, 2005.ENGLISH ABSTRACT: Cryotherapy is one of the popular treatments used to alleviate muscle soreness, especially in the competitive sports arena. However, the therapeutic use of cryotherapy is unsubstantiated because of a lack of proper investigations in the literature, especially a hypothesised effect on muscle recovery. Thus, our aims were to characterise satellite cell (SC) activity in human subjects with delayed onset muscle soreness (DOMS) and to shed light on the effect of cryotherapy on SC activity. DOMS was induced in six male subjects (24 ± 3 years) by completion of a downhill-run (DHR) protocol (5 x 8 min bouts, 2 min rest between bouts) at 70 or 80% of their individual peak treadmill speed. Ice application was applied to only one leg per subject for 3 days: 30 min every 2 hours, 5 times per day. In total 5 muscle biopsies were obtained from each subject: 1 baseline and 4 post-DHR. Post-DHR biopsies: 1 from each leg on day 1 and 7 (1st group, n=3) and 1 from each leg on day 2 and 9 (2nd group, n=3). DOMS was successfully induced as indicated by significant increases in muscle soreness at days 1 and 2 post-DHR (P < 0.01), and creatine kinase activity at day 1 post-DHR (P < 0.01). No difference in muscle soreness was found between treated and untreated legs. SC quiescence and activation were characterised by their expression of the cell surface markers CD34 and CD56 respectively. No significant change in quiescent SC was observed in the untreated or treated legs over time. However, at day 1 post-DHR the number of quiescent SC was significantly lower in the untreated compared with the treated leg (P < 0.05). There was a significant increase in activated SC numbers at day 2 post-DHR in the untreated leg, which was sustained up to day 9 post-DHR (P < 0.01). However, no such increase was found in biopsies taken on days 1 and 7. Also, no change was found in the treated leg, however a significant difference between the number of activated SC in untreated and treated legs on days 2 and 9 post-DHR (P < 0.01) was seen. No significant effect of DOMS or ice treatment was observed for the expression of the myogenic regulatory factors, MyoD and myogenin. C2C12 cell cultures induced to differentiate, however, did stain using these antibodies. This is the first study to report an effect of cryotherapy at the tissue level. In conclusion, this study highlights many unanswered questions on the SC response to DOMS at tissue level, and lays a good foundation for future studies.
AFRIKAANSE OPSOMMING: Kreoterapie is een van die gewilde behandelings wat gebruik word om spierseerheid te verlig, veral in die kompeterende sport arena, maar die gebruik van kreoterapie is onbevestig as gevolg van ‘n gebrek aan voldoende ondersoeke in die literatuur, veral ‘n hipotese oor die effek op spier-herstel. Ons doelstellings was dus om satellietsel (SC) aktiwiteit te ondersoek in mens proefpersone met vertraagde aanvang spierseerheid (DOMS) en ook om lig te werp op die effek van kreoterapie op SC aktiwiteit. DOMS was in ses mans proefpersone (24 ± 3 jare) geїnduseer deur voltooїng van ‘n afdraend-hardloop (DHR) protokol (5 x 8 min rondtes, 2 min rus tussen rondtes) teen 70 of 80% van elkeen se individuele maksimum trapmeul-spoed. Ys was vir 3 dae op net een been per proefpersoon aangewend: 30 min elke 2 ure, 5 keer per dag. 5 spierbiopsies in totaal was van elke proefpersoon verkry: 1 basislyn en 4 post-DHR. Post-DHR biopsies: 1 van elke been op dae 1 en 7 (1ste groep, n=3) en 1 van elke been op dae 2 en 9 (2de groep, n=3). DOMS was suksesvol geїnduseer soos aangedui deur die betekenisvolle verhogings in spierseerheid op dae 1 en 2 post-HR (P < 0.01) en kreatien kinase aktiwiteit op dag 1 post-DHR (P < 0.01). Geen verskil in spierseerheid is gevind tussen die onbehandelde en behandelde bene nie. SC dormansie en aktivering was gekarakteriseer deur die onderskeidelike uitdrukking van die sel oppervlak merkers CD34 en CD56. Geen betekenisvolle verandering is in SC dormansie in die onbehandelde en behandelde bene waargeneem nie, maar op dag 1 post-DHR was die getal dormante SC betekenisvol laer in die onbehandelde been as in die behandelde been (P < 0.05). Daar was ‘n betekenisvolle verhoging in die getalle geaktiveerde SC op dag 2 post-DHR in die onbehandelde been wat volgehou was tot op dag 9 post-DHR (P < 0.01), maar so ‘n verhoging was nie in biopsies wat op dae 1 en 7 geneem is gevind nie. Daar is ook geen verandering in die behandelde been gevind nie, maar ‘n betekenisvolle verskil in die getal geaktiveerde SC is tussen die onbehandelde en behandelde bene op dae 2 en 9 post-DHR gevind(P < 0.01). Geen betekenisvolle effek van DOMS en ys-aanwending vir die uitdrukking van die miogeniese (myogenic) regulatoriese faktore, MyoD en myogenin, is waargeneem nie. C2C12 sel kulture wat geїnduseer is om te differensieer het wel gekleur vir hierdie antiliggame. Dit is die eerste studie wat ‘n effek van kreoterapie op weefselvlak rapporteer. Ten slotte, hierdie studie beklemtoon baie onbeantwoorde vrae oor die SC respons op DOMS op weefselvlak en dit lê ‘n goeie grondslag neer vir toekomstige studies.
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Konovalenko, Zhanna. "Gene association of a-B-crystallin with R577X polymorphism for ACTN3 and nociception in subjects with TMD-related myalgia." Master's thesis, Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/399141.
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Oral BiologyM.S.
Masseter muscle is one of the major muscles of mastication, and is comprised of actin and myosin myofibrils organized into sarcomeric contractile units. Structurally, sarcomeres are repeating portions of myofibrils between neighboring Z-lines (a.k.a. Z-disc, Z-band). The Z-line or Z-disc is composed of non-contractile proteins that provide mechanical stability to the sarcomere. One of the proteins of Z-disc is alpha-B-crystallin, a protein product of the gene CRYAB. Together with several other proteins of the Z-disc, CRYAB gene has been found to be up-regulated in Actn3 knock-out mice. In addition, CRYAB is suspected to be a pain mediator gene, having similar structure and function to CRYAA (alpha,A-crystallin) identified as one of the candidate genes from the Pain Research Panel, previously investigated in the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) Study. Finally, in a microarray of global gene expression CRYAB was increased in subjects with facial asymmetry. We have examined CRYAB expression in masseter muscle of 64 orthognathic surgery patients to determine associations with skeletal malocclusions. Salivary DNA was genotyped for a single nucleotide polymorphism (SNP) for ACTN3 (rs1815739) and masseter muscle RNA isolated from an orthognathic surgery patient population. These genotyping and expression data have been used to identify differences in CRYAB expression in sub-groups of our patient population with Class II and III, normal, open and deep bite malocclusions who are null for ACTN3. In addition, we evaluated expression levels of CRYAB in patients with TMD-related myalgia. We found that relative quantities of CRYAB expression differed very significantly between sexes (p=0.005). ANOVA comparison between all subjects with and without TMD-myalgia indicated that males with TMD-myalgia had significantly greater (p<0.02) expression than other groups. An unpaired t-test showed that with TMD-related myalgia, CRYAB expression was significantly higher (p=0.03) in males than in females. ANOVA comparison between sexes with Class II and Class III malocclusions showed greater expression of CRYAB (p=0.005) in males with Class II. Expression was likewise greater in males with Class III malocclusion than in females with Class III (p<0.01). Among different age groups, subjects 25 years of age or younger had significantly (p value=0.025) increased expression of CRYAB gene. There were no significant differences for genotypes or facial asymmetry.
Temple University--Theses