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1

Smith, Jerry D., Ku-Lang Chang, and John G. Gums. "Possible Lansoprazole-Induced Eosinophilic Syndrome." Annals of Pharmacotherapy 32, no. 2 (February 1998): 196–200. http://dx.doi.org/10.1345/aph.17190.

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OBJECTIVE: To report a case of myalgia with eosinophilia related to lansoprazole administration. CASE SUMMARY: A 50-year-old white woman developed severe myalgia 1 week after starting lansoprazole. During the treatment course, the patient was also found to have eosinophilia. The myalgia and eosinophilia resolved 40 days after lansoprazole was stopped and 18 days after prednisone therapy was begun. The patient was not rechallenged with lansoprazole. DISCUSSION: To our knowledge, this is the first reported case of lansoprazole-induced eosinophilic syndrome. Clinically, it is difficult to distinguish between eosinophilia–myalgia syndrome and eosinophilic fasciitis, which are probably part of a continuum of eosinophilic disorders. This patient presented with symptoms of both syndromes. Although other causes cannot be completely ruled out, the time course strongly suggests that lansoprazole was the causative agent. CONCLUSIONS: It is important to consider medications when diagnosing patients with hypereosinophilia and/or myalgia. OBJETIVO: Informar un caso de mialgia con eosinofilia relacionado con la administración de lansoprazol. RESUMEN DEL CASO: Una mujer de 50 años desarrolló una mialgia severa 1 semana después de empezar terapia con lansoprazol. Además se encontró que diagnosticaba de eosinofilia. La mialgia y la eosinofilia se resolvieron 40 días después de detener la terapia con lansoprazol y 18 días después de empezar terapia con prednisona. No se le volvió a administrar lansoprazol a la paciente. DISCUSIÓN: Según nuestro conocimiento, este es el primer caso informado del síndrome de eosinofilia inducida por lansoprazol. Clínicamente, es difícil distinguir entre el síndrome de eosinofilia-mialgia y fascitis eosinofilica, las que probablemente forman parte de desórdenes eosinofílicos. El paciente presentaba síntomas similares a ambos síndromes. Aunque no se pueden eliminar otras causas, el curso clínico de este caso sugiere que lansoprazol era el agente causante. CONCLUSIONES: Es importante tomar en consideración los medicamentos cuando se diagnostican pacientes con hipereosinofilia y/o mialgia. OBJECTIF: Présenter un cas de myalgie avec éosinophile associée à l'administration de lansoprazole. RÉSUMÉ DU CAS: Une patiente de 50 ans, a développé des myalgies importantes 1 semaine après le début d'un traitement au lansoprazole. On a aussi découvert une éosinophilie chez cette patiente. Les myalgies et l'éosinophilie ont disparu 40 jours après l'arrêt du lansoprazole et 18 jours après le début d'un traitement à la prednisone. La patiente n'a pas été réexposée au lansoprazole. DISCUSSION: Ceci est le premier cas de syndrome d'éosinophilie induit par le lansoprazole rapporté dans la littérature. En clinique, il est difficile de distinguer entre un syndrome éosinophilie-myalgie et une fasciite à éosinophiles. Ces deux diagnostics faisant probablement partie d'un continuum de maladies touchant les éosinophiles. Cette patiente s'est présentée avec des symptômes compatibles avec les deux diagnostics. Bien que d'autres causes n'aient pas été complètement éliminées, l'évolution temporelle suggère fortement un lien de causalité avec le lansoprazole. CONCLUSIONS: Il demeure important de suspecter la médication lorsqu'on doit évaluer un patient qui se présente avec une hyperéosinophilie et/ou une myalgie.
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2

Sjøgaard, Gisela, Mette K. Zebis, Kristian Kiilerich, Bengt Saltin, and Henriette Pilegaard. "Exercise Training and Work Task Induced Metabolic and Stress-Related mRNA and Protein Responses in Myalgic Muscles." BioMed Research International 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/984523.

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The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with myalgia performed ~7 hrs repetitive stressful work and were subsequently randomized to 10 weeks of specific strength training, general fitness training, or reference intervention. Muscles biopsies were taken from the trapezius muscle at baseline, after work and after 10 weeks intervention. The main findings are that the capacity of carbohydrate oxidation was reduced in myalgic compared with healthy muscle. Repetitive stressful work increased mRNA content for heat shock proteins and decreased levels of key regulators for growth and oxidative metabolism. In contrast, prolonged general fitness as well as specific strength training decreased mRNA content of heat shock protein while the capacity of carbohydrate oxidation was increased only after specific strength training.
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3

Byrne, Edward. "Idiopathic chronic fatigue and myalgia syndrome (myalgic encephalomyelitis): some thoughts on nomenclature and aetiology." Medical Journal of Australia 148, no. 2 (January 1988): 80–82. http://dx.doi.org/10.5694/j.1326-5377.1988.tb104513.x.

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4

Palmio, Johanna, Satu Sandell, Michael G. Hanna, Roope Männikkö, Sini Penttilä, and Bjarne Udd. "Predominantly myalgic phenotype caused by the c.3466G>A p.A1156T mutation in SCN4A gene." Neurology 88, no. 16 (March 22, 2017): 1520–27. http://dx.doi.org/10.1212/wnl.0000000000003846.

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Objective:To characterize the clinical phenotype in patients with p.A1156T sodium channel mutation.Methods:Twenty-nine Finnish patients identified with the c.3466G>A p.A1156T mutation in the SCN4A gene were extensively examined. In a subsequent study, 63 patients with similar myalgic phenotype and with negative results in myotonic dystrophy type 2 genetic screening (DM2-neg group) and 93 patients diagnosed with fibromyalgia were screened for the mutation. Functional consequences of the p.A1156T mutation were studied in HEK293 cells with whole-cell patch clamp.Results:The main clinical manifestation in p.A1156T patients was not myotonia or periodic paralysis but exercise- and cold-induced muscle cramps, muscle stiffness, and myalgia. EMG myotonic discharges were detected in most but not all. Electrophysiologic compound muscle action potentials exercise test showed variable results. The p.A1156T mutation was identified in one patient in the DM2-neg group but not in the fibromyalgia group, making a total of 30 patients so far identified. Functional studies of the p.A1156T mutation showed mild attenuation of channel fast inactivation.Conclusions:The unspecific symptoms of myalgia stiffness and exercise intolerance without clinical myotonia or periodic paralysis in p.A1156T patients make the diagnosis challenging. The symptoms of milder SCN4A mutations may be confused with other similar myalgic syndromes, including fibromyalgia and myotonic dystrophy type 2.
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5

O-Lee, Tsungju, Charles E. Stewart, Loren Seery, and Christopher A. Church. "Fluoroquinolone-Induced Arthralgia and Myalgia in the Treatment of Sinusitis." American Journal of Rhinology 19, no. 4 (July 2005): 395–99. http://dx.doi.org/10.1177/194589240501900413.

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Background Because of their broad-spectrum coverage, fluoroquinolone antibiotics are widely used in the treatment of acute sinusitis and acute exacerbations of chronic sinusitis. Generally, they are well tolerated, and adverse effects are usually mild. In our experience with quinolones, patients have frequently complained of arthralgias and/or myalgias. Although tendon rupture has been described as one of the more severe side effects, there are few published reports of arthralgias and/or myalgias associated with these drugs. Methods A retrospective review of fluoroquinolone prescriptions in a tertiary rhinology clinic was completed. Patients treated with oral levofloxacin for sinusitis over a 12-month period were contacted by mail and asked to complete an anonymous survey regarding adverse effects. Of 81 patients identified, 36 responses were received. Results Among respondents, the incidence of arthralgias and/or myalgias was 25%, which was more than twice the incidence of any other adverse effect reported. Occurrence of arthralgias and/or myalgias did not appear to be influenced by respondent age, course length, concurrent use of oral steroids, or a history of arthritis. Among those reporting arthralgia or myalgia, symptoms began after an average of 3 days of therapy and resolved an average of 7.5 days after cessation of treatment. Fourteen percent of respondents were unable to complete their course of therapy because of arthralgias and/or myalgias. Conclusion Although effective and generally well tolerated in the treatment of sinusitis, fluoroquinolone antibiotics may produce adverse effects of arthralgia and/or myalgia.
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6

Schor, Anna M., and Ann Hellerstein. "Rhabdomyolysis Following a Short Course of Clarythromycin." Journal of Pediatric Pharmacology and Therapeutics 16, no. 3 (July 1, 2011): 216–17. http://dx.doi.org/10.5863/1551-6776-16.3.216.

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A healthy 5-year-old girl developed myalgia and an elevated creatine kinase concentration after 4 days of normal doses of clarithromycin. Myalgias resolved and creatine kinase values returned to normal following discontinuation of clarithromycin. No other precipitating factors or interacting drugs were identified; hence, clarithromycin was suspected as the cause of the rhabdomyolysis.
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7

Oliver, Nathan D., Auleen Millar, and Adrian Pendleton. "A Case Report on Parvovirus B19 Associated Myositis." Case Reports in Rheumatology 2012 (2012): 1–2. http://dx.doi.org/10.1155/2012/250537.

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Introduction. Whilst there are reports of viral myopathies affecting children and the immunocompromised, infective myositis is a relatively rare inflammatory myopathy in adults. The clinical spectrum can range from benign myalgias to more serious complications in certain risk groups.Case Presentation. We present two cases of myositis as a result of parvovirus B19 infection.Conclusion. Viral myositis and parvovirus B19 associated myositis should be considered in adults presenting with significant myalgia.
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8

Jensen, L., L. L. Andersen, H. D. Schrøder, U. Frandsen, and G. Sjøgaard. "Neuronal Nitric Oxide Synthase Is Dislocated in Type I Fibers of Myalgic Muscle but Can Recover with Physical Exercise Training." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/265278.

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Trapezius myalgia is the most common type of chronic neck pain. While physical exercise reduces pain and improves muscle function, the underlying mechanisms remain unclear. Nitric oxide (NO) signaling is important in modulating cellular function, and a dysfunctional neuronal NO synthase (nNOS) may contribute to an ineffective muscle function. This study investigated nNOS expression and localization in chronically painful muscle. Forty-one women clinically diagnosed with trapezius myalgia (MYA) and 18 healthy controls (CON) were included in the case-control study. Subsequently, MYA were randomly assigned to either 10 weeks of specific strength training (SST,n=18), general fitness training (GFT,n=15), or health information (REF,n=8). Distribution of fiber type, cross-sectional area, and sarcolemmal nNOS expression did not differ between MYA and CON. However, MYA showed increased sarcoplasmic nNOS localization (18.8 ± 12 versus 12.8 ± 8%,P=0.049) compared with CON. SST resulted in a decrease of sarcoplasm-localized nNOS following training (before 18.1 ± 12 versus after 12.0 ± 12%;P=0,027). We demonstrate that myalgic muscle displays altered nNOS localization and that 10 weeks of strength training normalize these disruptions, which supports previous findings of impaired muscle oxygenation during work tasks and reduced pain following exercise.
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9

Roy, E. Pierre, and Ludwig Gutmann. "Myalgia." Neurologic Clinics 6, no. 3 (August 1988): 621–36. http://dx.doi.org/10.1016/s0733-8619(18)30864-8.

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10

Gerwin, Robert D., Barbara Cagnie, Mirko Petrovic, Jo Van Dorpe, Patrick Calders, and Kayleigh De Meulemeester. "Foci of Segmentally Contracted Sarcomeres in Trapezius Muscle Biopsy Specimens in Myalgic and Nonmyalgic Human Subjects: Preliminary Results." Pain Medicine 21, no. 10 (April 14, 2020): 2348–56. http://dx.doi.org/10.1093/pm/pnaa019.

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Abstract Objective The myofascial trigger point hypothesis postulates that there are small foci of contracted sarcomeres in resting skeletal muscle. Only one example, in canine muscle, has been published previously. This study evaluated human muscle biopsies for foci of contracted sarcomeres. Setting The Departments of Rehabilitation Sciences and Physiotherapy at Ghent University, Ghent, Belgium. Subjects Biopsies from 28 women with or without trapezius myalgia were evaluated, 14 in each group. Methods Muscle biopsies were obtained from regions of taut bands in the trapezius muscle and processed for light and electron microscopy and for histochemical analysis. Examination of the biopsies was blinded as to group. Results A small number of foci of segmentally contracted sarcomeres were identified. One fusiform segmental locus involved the entire muscle fiber in tissue from a myalgic subject. Several transition zones from normal to contracted sarcomeres were found in both myalgic and nonmyalgic subjects. The distance between Z-lines in contracted sarcomeres was about 25–45% of the same distance in normal sarcomeres. Z-lines were disrupted and smeared in the contracted sarcomeres. Conclusions A small number of foci of segmentally contracted sarcomeres were found in relaxed trapezius muscle in human subjects, a confirmation of the only other example of spontaneous segmental contraction of sarcomeres (in a canine muscle specimen), consistent with the hypothesis of trigger point formation and with the presence of trigger point end plate noise.
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11

Maros, Kathleen. "Myalgic encephalomyelitis?" Medical Journal of Australia 148, no. 8 (April 1988): 424. http://dx.doi.org/10.5694/j.1326-5377.1988.tb115981.x.

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12

MATHER, J. S., and N. P. CARTER. "SUXAMETHONIUM MYALGIA." British Journal of Anaesthesia 61, no. 2 (August 1988): 238. http://dx.doi.org/10.1093/bja/61.2.238.

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13

O’SULLIVAN, E. P., N. E. WILLIAMS, and T. N. CALVEY. "SUXAMETHONIUM MYALGIA." British Journal of Anaesthesia 61, no. 2 (August 1988): 238. http://dx.doi.org/10.1093/bja/61.2.238-a.

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14

Lev, M. "Myalgic Encephalomyelitis." Journal of the Royal Society of Medicine 82, no. 11 (November 1989): 693–94. http://dx.doi.org/10.1177/014107688908201127.

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15

Rosen, S. D., J. C. King, and P. G. F. Nixon. "Myalgic Encephalomyelitis." Journal of the Royal Society of Medicine 83, no. 3 (March 1990): 199. http://dx.doi.org/10.1177/014107689008300336.

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16

Hodson, A. D. "Myalgic Encephalomyelitis." Journal of the Royal Society of Medicine 83, no. 3 (March 1990): 199–200. http://dx.doi.org/10.1177/014107689008300337.

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17

Wessely, S. "Myalgic Encephalomyelitis." Journal of the Royal Society of Medicine 84, no. 3 (March 1991): 182–83. http://dx.doi.org/10.1177/014107689108400338.

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18

Byrne, Edward. "Chronic myalgia." Current Opinion in Orthopaedics 3, no. 2 (April 1992): 229–35. http://dx.doi.org/10.1097/00001433-199204000-00018.

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19

Richardson, John. "Myalgic Enchephalomyelitis." Journal of Chronic Fatigue Syndrome 10, no. 1 (January 2002): 65–80. http://dx.doi.org/10.1300/j092v10n01_06.

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20

Gordon, Neil. "Myalgic Encephalomyelitis." Developmental Medicine & Child Neurology 30, no. 5 (November 12, 2008): 677–82. http://dx.doi.org/10.1111/j.1469-8749.1988.tb04808.x.

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21

Hartnell, L. "Myalgic encephalomyelitis." BMJ 298, no. 6687 (June 10, 1989): 1577–78. http://dx.doi.org/10.1136/bmj.298.6687.1577-b.

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22

Wookey, C. "Myalgic encephalomyelitis." BMJ 298, no. 6687 (June 10, 1989): 1578. http://dx.doi.org/10.1136/bmj.298.6687.1578.

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23

Walker, R. G. "Myalgic encephalomyelitis." BMJ 298, no. 6687 (June 10, 1989): 1578. http://dx.doi.org/10.1136/bmj.298.6687.1578-a.

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24

Kirkpatrick, Joel B. "Eosinophilia-myalgia." Human Pathology 22, no. 1 (January 1991): 1–2. http://dx.doi.org/10.1016/0046-8177(91)90053-r.

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25

Thadchanamoorthy, Vijayakumary, and Kavinda Dayasiri. "Postdengue chronic fatigue syndrome in an adolescent boy." BMJ Case Reports 14, no. 6 (June 2021): e238605. http://dx.doi.org/10.1136/bcr-2020-238605.

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Chronic fatigue syndrome (CFS) is often preceded by a viral illness and has recurrent ‘flulike’ symptoms which include a wide spectrum of musculoskeletal and neurological clinical features. The condition is also known as myalgic encephalomyelitis and systemic exertional intolerance syndrome. CFS has been reported following dengue among adult patients. We report the case of an 11-year-old boy who developed CFS following recovery of dengue haemorrhagic fever (DHF). The reported child was initially managed as for DHF and was clinically asymptomatic on post-discharge day 3. He was re-admitted after 3 weeks with severe joint pains, myalgia and unbearable headache. As his symptoms persisted, he was investigated in-depth. All investigations were normal except mild elevation of liver functions. The diagnosis of CFS secondary to DHF was made by exclusion of differential diagnosis. At 1-year follow-up, patient continues to have symptoms after treatment with physiotherapy and nutrition counselling.
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26

Gulia, Manisha, Preeti Dalal, Monica Gupta, and Daljinderjit Kaur. "Concurrent Guillain-Barré syndrome and myositis complicating dengue fever." BMJ Case Reports 13, no. 2 (February 2020): e232940. http://dx.doi.org/10.1136/bcr-2019-232940.

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Dengue is an arboviral infection that classically presents with fever, headache, joint pain, skin flush and morbilliform rashes. Neurological manifestations are well recognised but their exact incidence is unknown. Though myalgias are common in dengue virus infection, myositis and/or elevated serum creatine kinase is an uncommon complication. Guillain-Barré syndrome is another rare neurological manifestation associated with dengue fever. Here, we report the case of a 21-year-old man with serologically confirmed dengue fever presenting with severe myalgia, bilateral lower and upper limb weakness with raised creatine kinase, MRI suggestive of myositis and myonecrosis and nerve conduction velocity showing bilateral lower limb and axillary sensory motor neuropathy. He was managed conservatively and made an uneventful recovery.
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27

Troy, James L. "Eosinophilia-Myalgia Syndrome." Mayo Clinic Proceedings 66, no. 5 (May 1991): 535–38. http://dx.doi.org/10.1016/s0025-6196(12)62396-9.

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28

Staines, Donald. "Myalgic encephalomyelitis hypothesis." Medical Journal of Australia 143, no. 2 (July 1985): 91. http://dx.doi.org/10.5694/j.1326-5377.1985.tb122819.x.

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29

Schwarz, Karl O. "Clonidine‐induced myalgia." Medical Journal of Australia 147, no. 7 (October 1987): 365. http://dx.doi.org/10.5694/j.1326-5377.1987.tb133543.x.

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30

Ghiringhelli, Paolo. "A strange myalgia." Clinical Management Issues 2, no. 2 (June 15, 2008): 75–81. http://dx.doi.org/10.7175/cmi.v2i2.575.

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A 70-year-old man was admitted in our hospital with mild fever, pain, myalgia. His eosinophil count was high, leading to a diagnosis of hypereosinophilic syndrome. This case report gives rise to many questions regarding diagnosis and correct management of eosinophilic myopathies.
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31

Blackburn, Warren D. "Eosinophilia myalgia syndrome." Seminars in Arthritis and Rheumatism 26, no. 6 (June 1997): 788–93. http://dx.doi.org/10.1016/s0049-0172(97)80022-4.

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32

Burnell, J. C. "Myalgia and suxamethonium." Anaesthesia 49, no. 1 (January 1994): 87. http://dx.doi.org/10.1111/j.1365-2044.1994.tb03345.x.

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33

Mirakhur, R. K. "Myalgia and suxamethonium." Anaesthesia 49, no. 1 (January 1994): 87. http://dx.doi.org/10.1111/j.1365-2044.1994.tb03346.x.

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34

Teman, Allen Jay, and Brian Hainline. "Eosinophilia-Myalgia Syndrome." Physician and Sportsmedicine 19, no. 2 (February 1991): 80–86. http://dx.doi.org/10.1080/00913847.1991.11702147.

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35

UITTO, JOUNI, JOHN VARGA, JUHA PELTONEN, and SERGIO A. JIMENEZ. "EOSINOPHILIA-MYALGIA SYNDROME." International Journal of Dermatology 31, no. 4 (April 1992): 223–28. http://dx.doi.org/10.1111/j.1365-4362.1992.tb03558.x.

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36

SACK, KENNETH E., and LINDSEY A. CRISWELL. "Eosinophilia-Myalgia Syndrome." Southern Medical Journal 85, no. 9 (September 1992): 878–82. http://dx.doi.org/10.1097/00007611-199209000-00005.

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37

Duffy, Joseph. "Eosinophilia-Myalgia Syndrome." Mayo Clinic Proceedings 67, no. 12 (December 1992): 1201–2. http://dx.doi.org/10.1016/s0025-6196(12)61152-5.

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38

Gherardi, R. K., L. Ollivaud, G. Defer, and A. Schaeffer. "Eosinophilia-myalgia syndrome." Neurology 41, no. 5 (May 1, 1991): 764–65. http://dx.doi.org/10.1212/wnl.41.5.764-b.

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39

Smith, B. E., and P. J. Dyck. "Eosinophilia-myalgia syndrome." Neurology 41, no. 5 (May 1, 1991): 765. http://dx.doi.org/10.1212/wnl.41.5.765.

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40

Lasker, Shawarna S., and Tahseen A. Chowdbury. "Statin-induzierte Myalgie." Praxis 102, no. 4 (February 1, 2013): 231–32. http://dx.doi.org/10.1024/1661-8157/a001208.

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41

Haq, I., K. Moss, and V. H. Morris. "Myalgia with Lymphadenopathy." Journal of the Royal Society of Medicine 94, no. 10 (October 2001): 521–22. http://dx.doi.org/10.1177/014107680109401008.

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42

DOLENSK, S. "Suxamethonium-induced myalgia." British Journal of Anaesthesia 73, no. 1 (July 1994): 118. http://dx.doi.org/10.1093/bja/73.1.118.

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43

KAHRAMAN, S. "Suxamethonium-induced myalgia." British Journal of Anaesthesia 73, no. 1 (July 1994): 118. http://dx.doi.org/10.1093/bja/73.1.118-a.

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44

Swygert, Leslie A. "Eosinophilia-Myalgia Syndrome." JAMA 264, no. 13 (October 3, 1990): 1698. http://dx.doi.org/10.1001/jama.1990.03450130070029.

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45

Gibbons, Robert B. "Eosinophilia-Myalgia Syndrome." Archives of Internal Medicine 150, no. 10 (October 1, 1990): 2175. http://dx.doi.org/10.1001/archinte.1990.00390210129028.

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Philen, Rossanne M. "Eosinophilia-Myalgia Syndrome." Archives of Internal Medicine 151, no. 3 (March 1, 1991): 533. http://dx.doi.org/10.1001/archinte.1991.00400030083015.

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47

Hedberg, Katrina. "Eosinophilia-Myalgia Syndrome." Archives of Internal Medicine 152, no. 9 (September 1, 1992): 1889. http://dx.doi.org/10.1001/archinte.1992.00400210111019.

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48

Kazura, J. W. "Eosinophilia-myalgia syndrome." Cleveland Clinic Journal of Medicine 58, no. 3 (May 1, 1991): 267–70. http://dx.doi.org/10.3949/ccjm.58.3.267.

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49

Miteva, Maria, Johannes Norgauer, and Mirjana Ziemer. "Diplopia and Myalgia." American Journal of Clinical Dermatology 8, no. 3 (2007): 175–78. http://dx.doi.org/10.2165/00128071-200708030-00004.

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50

Constantini, Naama W., Shachar Nice, and Ran Shabtai. "Recurrent Myalgia - Athletics." Medicine & Science in Sports & Exercise 47 (May 2015): 595. http://dx.doi.org/10.1249/01.mss.0000478338.79417.fa.

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