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Journal articles on the topic 'Myasthenic'

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1

van Lunteren, Erik, Michelle Moyer, and Henry J. Kaminski. "Adverse effects of myasthenia gravis on rat phrenic diaphragm contractile performance." Journal of Applied Physiology 97, no. 3 (2004): 895–901. http://dx.doi.org/10.1152/japplphysiol.01266.2003.

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Myasthenia gravis has variable effects on the respiratory system, ranging from no abnormalities to life-threatening respiratory failure. Studies characterized diaphragm muscle contractile performance in rat autoimmune myasthenia gravis. Rats received monoclonal antibody that recognizes acetylcholine receptor determinants (or inactive antibody); 3 days later, phrenic nerve and diaphragm were studied in vitro. Myasthenic rats segregated into two groups, those with normal vs. impaired limb muscle function when tested in intact animals (“mild” and “severe” myasthenic). Baseline diaphragm twitch fo
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2

Saraiva, Paulo A. P., José Lamartine de Assis, and Paulo E. Marchiori. "Evaluation of the respiratory function in myasthenia gravis: an important tool for clinical feature and diagnosis of the disease." Arquivos de Neuro-Psiquiatria 54, no. 4 (1996): 601–7. http://dx.doi.org/10.1590/s0004-282x1996000400009.

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Myasthenic gravis may affect both inspiratory and expiratory muscles. Respiratory involvement occurred in almost all patients with myasthenia gravis in all clinical forms of the disease: 332 lung function tests done in 324 myasthenic patients without respiratory symptoms (age 34.6 ± 18.3 years) were examined. Lung volumes analysis showed that all the patients of both sexes with generalized or ocular myasthenia gravis showed "myasthenic pattern". Male patients with "ocular" form only presented the "myasthenic pattern" with lung impairment and had, from the lung function point of view, a more be
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3

Kruglyakov, N. M., D. G. Levitova, G. I. Bagzhanov, et al. "Application of the Technique of Extracorporeal Membrane Oxygenation in a Patient With Respiratory Distress Syndrome Associated With Myasthenia Gravis." Russian Sklifosovsky Journal "Emergency Medical Care" 10, no. 2 (2021): 393–400. http://dx.doi.org/10.23934/2223-9022-2021-10-2-393-400.

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Myasthenia gravis is an autoimmune neuromuscular disease characterized by pathologically rapid fatigue of striated muscles [1]. The main symptom of myasthenia gravis is the presence of pathological muscle weakness with involvement of the ocular, bulbar and skeletal muscles in the pathological process. The provoking factors for the development of myasthenia gravis can be infectious diseases, surgery, drugs [2, 3]. The main danger is represented by myasthenic and cholinergic crises, which are characterized by a severe course and high mortality; therefore, the problems of treating myasthenia grav
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4

Schroeter, Michael, Günther Thayssen, and Julia Kaiser. "Myasthenia Gravis – Exacerbation and Crisis." Neurology International Open 02, no. 01 (2018): E10—E15. http://dx.doi.org/10.1055/s-0043-118441.

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AbstractMyasthenic exacerbation and crisis are most critical incidences in myasthenia gravis. Even nowadays myasthenic crisis is a life-threatening condition, with a lethality of 2–3%. We review means of avoiding myasthenic exacerbation and crisis, elaborate on red flags and how to establish highly-active therapy in a timely manner. This includes the reasonable use of cholinesterase inhibitors, immunoadsorption or plasma exchange, as well as immunoglobulins and steroids. Immunosuppressive agents and monoclonal antibody therapy add to the therapeutic options.Intensive care of myasthenic patient
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5

Job, Anand, R. Raman, and C. Gnanamuthu. "Laryngeal stridor in myasthenia gravis." Journal of Laryngology & Otology 106, no. 7 (1992): 633–34. http://dx.doi.org/10.1017/s0022215100120390.

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AbstractTwo patients with laryngeal stridor secondary to myasthenia gravis are reported. The cause of bilateral abductor weakness in myasthenia is discussed; anticipation of the stridor in myasthenic patients is highlighted.
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6

Anand, Uttara Swati, Stalin Viswanathan, and Jayanthi Arulneyam. "Pulmonary Edema in Myasthenic Crisis." Case Reports in Critical Care 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/863620.

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We report a previously asymptomatic 50-year-old lady who came with myasthenic crisis as initial presentation of myasthenia gravis. She developed pulmonary edema following intravenous immunoglobulin administration and had ischemic changes in ECG and left ventricular dysfunction on echocardiography. She improved with diuretics, dobutamine, and fluid restriction alone. This is the first report in English-language medical literature describing the association between myasthenic crisis and likely takotsubo cardiomyopathy-related pulmonary edema following intravenous immunoglobulin administration.
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7

Itoh, Hironori, Keizo Shibata, Masahiro Yoshida, and Ken Yamamoto. "Neuromuscular Monitoring at the Orbicularis Oculi May Overestimate the Blockade in Myasthenic Patients." Anesthesiology 93, no. 5 (2000): 1194–97. http://dx.doi.org/10.1097/00000542-200011000-00010.

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Background In most publications about myasthenia, monitoring neuromuscular blockade during anesthesia is recommended. In healthy patients, the relation of blockade between muscles has been established, but there is little information about the relation in myasthenic patients. Our objective was to investigate whether the relation between the orbicularis oculi and adductor pollicis muscles is the same in healthy patients and myasthenic patients. Methods After anesthesia was induced with 4-6 mg/kg thiopental and 2 microg/kg fentanyl, followed by 2% sevoflurane and 60% nitrous oxide in oxygen, 10
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8

Zaloum, A., JR Falet, A. Elkrief, and C. Chalk. "P.022 Myasthenia gravis following dabrafenib and trametinib for metastatic melanoma." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, s1 (2019): S19. http://dx.doi.org/10.1017/cjn.2019.122.

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Background: Inhibitors of BRAF and MEK, enzymes in the mitogen-activated protein kinase (MAPK) pathway, are now widely used in the treatment of metastatic melanoma. We report a case of acetylcholine receptor (AChR) antibody-positive myasthenia gravis developing after exposure to dabrafenib, a BRAF inhibitor, and trametinib, a MEK inhibitor. Methods: A 68-year-old man presented with dysarthria, dysphagia, cough, dyspnea, and fever. Examination revealed fatigable ptosis and proximal muscle weakness. He had started dabrafenib and trametinib for metastatic melanoma two weeks prior. He was diagnose
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9

Souza, Paulo Victor Sgobbi de, Gabriel Novaes de Rezende Batistella, Valéria Cavalcante Lino, Wladimir Bocca Vieira de Rezende Pinto, Marcelo Annes, and Acary Souza Bulle Oliveira. "Clinical and genetic basis of congenital myasthenic syndromes." Arquivos de Neuro-Psiquiatria 74, no. 9 (2016): 750–60. http://dx.doi.org/10.1590/0004-282x20160106.

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ABSTRACT Neuromuscular junction disorders represent a wide group of neurological diseases characterized by weakness, fatigability and variable degrees of appendicular, ocular and bulbar musculature involvement. Its main group of disorders includes autoimmune conditions, such as autoimmune acquired myasthenia gravis and Lambert-Eaton syndrome. However, an important group of diseases include congenital myasthenic syndromes with a genetic and sometimes hereditary basis that resemble and mimick many of the classic myasthenia neurological manifestations, but also have different presentations, which
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10

Benatar, M. "Myasthenia Gravis and Myasthenic Disorders." Neurology 81, no. 1 (2013): 99. http://dx.doi.org/10.1212/wnl.0b013e318297ef4d.

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11

Kostera-Pruszczyk, A. "Myasthenia gravis and myasthenic syndromes." European Journal of Paediatric Neurology 12 (May 2008): S17. http://dx.doi.org/10.1016/s1090-3798(08)70056-4.

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12

Karachunski, P. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S47. http://dx.doi.org/10.1016/j.nmd.2018.06.084.

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13

García Erro, M., E. Cavassa, J. Muntadas, M. Pauni, and G. Vázquez. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S47—S48. http://dx.doi.org/10.1016/j.nmd.2018.06.085.

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14

Rugiero, M., V. Salutto, V. Alvarez, M. Bettini, N. Genco, and C. Mazia. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S48. http://dx.doi.org/10.1016/j.nmd.2018.06.086.

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15

de Meel, R., K. Keene, M. Tannemaat, and J. Verschuuren. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S48. http://dx.doi.org/10.1016/j.nmd.2018.06.087.

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16

Vajsar, J., H. Katzberg, H. Qashqari, N. Chrestian, and I. Narang. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S48. http://dx.doi.org/10.1016/j.nmd.2018.06.088.

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17

Rugiero, M., M. Bettini, F. Silveira, F. Sosa Albacete, and S. Christiansen. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S48—S49. http://dx.doi.org/10.1016/j.nmd.2018.06.089.

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18

Ho, S., J. So, and D. Bae. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S49. http://dx.doi.org/10.1016/j.nmd.2018.06.090.

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19

So, J., S. Ho, and D. Bae. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S49. http://dx.doi.org/10.1016/j.nmd.2018.06.091.

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20

Louet, E., S. Misdrahi, C. Orblin Bedos, et al. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S49. http://dx.doi.org/10.1016/j.nmd.2018.06.092.

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21

Zhang, Y., R. Ban, H. Liu, C. Pu, and Q. Shi. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S49—S50. http://dx.doi.org/10.1016/j.nmd.2018.06.093.

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22

Eymard, B., D. Sternberg, M. Mayer, et al. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S50. http://dx.doi.org/10.1016/j.nmd.2018.06.094.

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23

Shen, X., D. Selcen, J. Brengman, et al. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S50. http://dx.doi.org/10.1016/j.nmd.2018.06.095.

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24

Estephan, E., A. Zambon, P. Marchiori, et al. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S50. http://dx.doi.org/10.1016/j.nmd.2018.06.096.

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25

Coppens, S., G. Glibert, and N. Deconinck. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S51. http://dx.doi.org/10.1016/j.nmd.2018.06.097.

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26

Gidaro, T., L. Vandenbrande, E. Malfatti, et al. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S51. http://dx.doi.org/10.1016/j.nmd.2018.06.098.

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27

Jonsrud, C., P. Aden, G. Hansen, et al. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S51. http://dx.doi.org/10.1016/j.nmd.2018.06.099.

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28

Rodriguez Cruz, P., J. Palace, and D. Beeson. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S51—S52. http://dx.doi.org/10.1016/j.nmd.2018.06.100.

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29

Balaraju, S., A. Töpf, P. Veeramani, et al. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S52. http://dx.doi.org/10.1016/j.nmd.2018.06.101.

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30

Munell, F., D. Gomez-Andrés, L. Costa Comellas, et al. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S52. http://dx.doi.org/10.1016/j.nmd.2018.06.102.

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31

Selby, V., G. Ramdharry, M. Hanna, and F. Muntoni. "CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA." Neuromuscular Disorders 28 (October 2018): S52. http://dx.doi.org/10.1016/j.nmd.2018.06.103.

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32

Vacca, Vincent M. "Myasthenia gravis and myasthenic crisis." Nursing Critical Care 12, no. 5 (2017): 38–46. http://dx.doi.org/10.1097/01.ccn.0000521932.75838.5c.

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33

Sanders, Donald B. "Myasthenia gravis and myasthenic disorders." Annals of Neurology 48, no. 5 (2000): 820. http://dx.doi.org/10.1002/1531-8249(200011)48:5<820::aid-ana24>3.0.co;2-q.

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34

Antozzi, C. "Myasthenia gravis and myasthenic syndrome." Neurological Sciences 24 (October 1, 2003): s260—s263. http://dx.doi.org/10.1007/s10072-003-0091-5.

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35

Lobzin, S. V., M. G. Sokolova, V. A. Shavurov, and A. A. Zuev. "EMERGENCY CARE OF CRISIS CONDITIONS IN MYASTHENIA GRAVIS." EMERGENCY MEDICAL CARE 20, no. 2 (2019): 25–30. http://dx.doi.org/10.24884/2072-6716-2019-20-2-25-30.

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The article presents an analysis of current data on emergency management of crises in patients with myasthenia gravis, which is supplemented by our own observations of 892 patients with myasthenia gravis. A follow-up study was conducted, which helped us to assess the frequency, nature and course of crises in patients with myasthenia gravis, taking into account the form of the disease, sex and age of patients. It was found that crises were observed in 154 (17.4%) patients, these conditions were significantly more often registered at the age of 20 to 40 and in the first three years of the diseas
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36

Ashjazadeh, Nahid, Maryam Sharifian Dorche, Soheila Zareifar, Masood Nomovi, and Amirhossein Sharian Dorche. "Rare Coexistence of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome with Adenocarcinoma of the Bladder: A Case Report." Internal Medicine and Medical Investigation Journal 2, no. 4 (2017): 171. http://dx.doi.org/10.24200/imminv.v2i4.71.

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Abstract Introduction: The coexistence of myasthenia gravis and Lambert-Eaton myasthenic syndrome (LEMS) is very rare.Case report: Herein we report an 82 year old man a known case of adenocarcinoma of bladder who came with ptosis in left eye, diplopia, and dysphagia, weakness of both lower extremities and autonomic dysfunction. According to history, physical examination and para clinical work ups coexisting of myasthenia gravis and LEMS was diagnosed.Discussion: our patient is the first patient with Overlap myasthenic syndrome on the base of adenocarcinoma of bladder. The purpose of this case
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37

Ciafaloni, Emma. "Myasthenia Gravis and Congenital Myasthenic Syndromes." CONTINUUM: Lifelong Learning in Neurology 25, no. 6 (2019): 1767–84. http://dx.doi.org/10.1212/con.0000000000000800.

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38

Sharp, H. R., A. Degrip, D. B. Mitchell, and A. Heller. "Bulbar presentations of myasthenia gravis in the elderly patient." Journal of Laryngology & Otology 115, no. 1 (2001): 1–3. http://dx.doi.org/10.1258/0022215011906740.

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We report on three cases of patients whose primary symptoms of myasthenia gravis were related to the upper aerodigestive tract. Symptoms had been present unrecognized in all patients for up to three years, and one patient subsequently developed a myasthenic crisis. We highlight the clinical features of myasthenia gravis to allow its prompt recognition in patients presenting to the ENT surgeon or physician.
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39

Ho, Stacey, and Antonio Liu. "A Co-Occurrence of Serologically Proven Myasthenia Gravis and Pharyngeal-Cervical-Brachial Variant of Guillain-Barré Syndrome." Case Reports in Neurological Medicine 2019 (April 8, 2019): 1–3. http://dx.doi.org/10.1155/2019/4695010.

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We report on a co-occurrence case of ocular myasthenia gravis with exacerbation leading to myasthenic crisis in addition to pharyngeal-cervical-brachial variant of Guillain–Barré syndrome in a patient with severe oropharyngeal dysphagia and acute respiratory failure.
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40

Garcia, Catherine R., Jessica N. Cox, and John L. Villano. "Myasthenia gravis and Guillain-Barré syndrome adverse events with immune checkpoint inhibitors." Journal of Clinical Oncology 36, no. 5_suppl (2018): 37. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.37.

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37 Background: Immune checkpoint inhibitors (ICI) have provided landmark breakthrough achieving success in prolonging survival in multiple cancer types. As a new class of therapy immune related serious adverse drug reactions (sADRs) have had limited reporting. This includes neurologic based, with reports limited to clinical trials and case-based. Ours is the largest database analysis to date reporting neurological adverse events after ICI therapy. Methods: We analyzed the FDA Adverse Event Reporting System (FAERS) database for pembrolizumab, atezolizumab, nivolumab, and ipilimumab two years pr
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41

Cetin, Hakan, and Angela Vincent. "Pathogenic Mechanisms and Clinical Correlations in Autoimmune Myasthenic Syndromes." Seminars in Neurology 38, no. 03 (2018): 344–54. http://dx.doi.org/10.1055/s-0038-1660500.

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AbstractAutoimmune myasthenic syndromes are antibody-mediated disorders of the neuromuscular junction. Common antigenic targets are the acetylcholine receptor or muscle specific kinase (MuSK) in myasthenia gravis (MG) and the voltage-gated calcium channel in Lambert-Eaton myasthenic syndrome. There is evidence that antibodies directed against other antigens such as low-density lipoprotein receptor-related protein 4 (LRP4) are also involved in MG. The mechanisms by which various antibodies exert their pathogenic effect depend on the IgG subclass and also the epitope location on the antigens. Th
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42

Bonanni, Luca, Michele Dalla Vestra, Andrea Zancanaro, and Fabio Presotto. "Myasthenia Gravis following Low-Osmolality Iodinated Contrast Media." Case Reports in Radiology 2014 (2014): 1–2. http://dx.doi.org/10.1155/2014/963461.

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We describe the case of 79-year-old man admitted to our general hospital for a 6-week history of progressive dysphagia to solids and liquids associated with weight loss. To reach a diagnosis a total body CT scan with low-osmolality iodinate contrast agent was performed. Two hours later the patient developed an acute respiratory failure requiring orotracheal intubation and mechanical ventilation. The laboratory and neurological tests allow formulating the diagnosis of myasthenia gravis. In literature, other three case reports have associated myasthenic crisis with exposure to low-osmolality con
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43

Finnis, Maria F., and Sandeep Jayawant. "Juvenile Myasthenia Gravis: A Paediatric Perspective." Autoimmune Diseases 2011 (2011): 1–7. http://dx.doi.org/10.4061/2011/404101.

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Myasthenia gravis (MG) is an autoimmune disease in which antibodies are directed against the postsynaptic membrane of the neuromuscular junction, resulting in muscle weakness and fatigability. Juvenile myasthenia gravis (JMG) is a rare condition of childhood and has many clinical features that are distinct from adult MG. Prepubertal children in particular have a higher prevalence of isolated ocular symptoms, lower frequency of acetylcholine receptor antibodies, and a higher probability of achieving remission. Diagnosis in young children can be complicated by the need to differentiate from cong
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44

Matthews, Harrison J., Apisadaporn Thambundit, and Brandon R. Allen. "Anti-MuSK-Positive Myasthenic Crisis in a 7-Year-Old Female." Case Reports in Emergency Medicine 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/8762302.

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A seven-year-old African American female with anti-MuSK-positive Juvenile Myasthenia Gravis collapsed while at school from progressively worsening weakness and dyspnea. On initial emergency department presentation, she required 15 liters per minute of supplemental oxygen to maintain oxygen saturation above 92%. Initial pulmonary function tests and venous blood gas led to the decision to place her on noninvasive positive pressure ventilation (NPPV) with BiPAP in the emergency department. Due to worsening hypercarbia, she later required mechanical intubation in the PICU and underwent IVIG therap
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45

De Haes, Ann, Johannes H. Proost, Mark H. De Baets, Maurice H. W. Stassen, Martin C. Houwertjes, and J. Mark K. H. Wierda. "Pharmacokinetic–Pharmacodynamic Modeling of Rocuronium in Case of a Decreased Number of Acetylcholine Receptors." Anesthesiology 98, no. 1 (2003): 133–42. http://dx.doi.org/10.1097/00000542-200301000-00022.

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Background In myasthenic patients, the sensitivity for nondepolarizing relaxants is increased and the time course of effect is prolonged due to a reduced number of functional acetylcholine receptors at the neuromuscular junction. The authors investigated both the performance of the link model proposed by Sheiner and a pharmacodynamic-pharmacokinetic model taking into account the number of unbound acetylcholine receptors in myasthenic pigs. Methods After obtaining the approval of the Animal Experiments Committee of their institution, the authors studied eight myasthenic pigs and eight control p
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46

Gogovska, L., R. Ljapcev, M. Polenakovic, L. Stojkovski, M. Popovska, and L. Grcevska. "Plasmaexchange in the Treatment of Myasthenia Gravis Associated with Thymoma." International Journal of Artificial Organs 26, no. 2 (2003): 170–73. http://dx.doi.org/10.1177/039139880302600212.

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Background All patients with thymomatous Myasthenia Gravis (MG) should undergo early and total thymectomy, but controversy abounds in the choice of chronic immunosuppressive agents. The value of plasmaexchange (PE) in MG has been clearly estabilshed in preoperative preparation and treatment of myasthenic crisis. Whether PE may be used in the chronic long-term therapy of patients with thymomatous MG in addition to conventional immunosuppressive agents and cholinesterase inhibitors is yet to be answered. Case history We present a 40-year old woman with an 11 year history of MG. Thymectomy was do
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47

Varma, AnoopRanjan. "What kills a myasthenic? Myasthenia or otherwise." Neurology India 65, no. 3 (2017): 525. http://dx.doi.org/10.4103/neuroindia.ni_350_17.

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48

Sanders, Donald B., and Jeffrey T. Guptill. "Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome." CONTINUUM: Lifelong Learning in Neurology 20 (October 2014): 1413–25. http://dx.doi.org/10.1212/01.con.0000455873.30438.9b.

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49

Dineen, Jennifer M., and Steven A. Greenberg. "Myasthenis Gravis or Lambert-Eaton Myasthenic Syndrome?" American Journal of Physical Medicine & Rehabilitation 94, no. 2 (2015): e20-e21. http://dx.doi.org/10.1097/phm.0000000000000176.

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50

Zajicek, J. "Handbook of Myasthenia Gravis and Myasthenic Syndromes." Journal of Neurology, Neurosurgery & Psychiatry 58, no. 6 (1995): 766. http://dx.doi.org/10.1136/jnnp.58.6.766.

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