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Journal articles on the topic 'Mycobacteria'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Manguba, Alexander S., Jaime Alfonso M. Aherrera, Antonio L. Faltado, Melissa A. Llanto, and Raul D. Jara. "Cardiac Tamponade Complicating Disseminated Non-tuberculous Mycobacterial Infection Involving the Pericardium: A Case Report." Philippine Journal of Cardiology 41, no. 1 (2013): 7–10. http://dx.doi.org/10.69944/pjc.598ed10d2d.

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BACKGROUND: The most common mycobacterial species causing infection in the Philippines is Mycobacterium tuberculosis. Non-tuberculous mycobacteria (NTM) have not been reported in Philippine literature to disseminate to the pericardium. CASE: We present a case of disseminated mycobacterial (tuberculous and non-tuberculous co-infection) involving the pericardium, pleura, spleen and abdominal wall. This is the case of a 37-year old female who presented with dyspnea and multiple nodules within the abdominal wall. Computed tomography scan showed a thickened pericardium with minimal pericardial effu

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Lutsenko, A. V., A. L. Yasenyavskaya, and M. A. Samotrueva. "Mycobacterial infections: features of microbiological diagnosis." Сибирский научный медицинский журнал 43, no. 6 (2024): 34–44. http://dx.doi.org/10.18699/ssmj20230604.

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To date, more than 200 species of mycobacteria have been identified, in addition to the well-known Mycobacterium leprae and Mycobacterium tuberculosis. Among microorganisms belonging to the genus Mycobacterium, there are obligate pathogenic, opportunistic and saprophytic strains. The incidence of non-tuberculous or atypical mycobacteria, which cause opportunistic infections in humans and animals, is steadily increasing. Non-tuberculous mycobacteria are increasingly recognized as a source of healthcare-associated infections.Aim of the study was to analyze the literature on current methods of mi

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Harth, Günter, Saša Masleša-Galić, and Marcus A. Horwitz. "A two-plasmid system for stable, selective-pressure-independent expression of multiple extracellular proteins in mycobacteria." Microbiology 150, no. 7 (2004): 2143–51. http://dx.doi.org/10.1099/mic.0.27113-0.

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Recombinant mycobacteria expressing Mycobacterium tuberculosis extracellular proteins are leading candidates for new vaccines against tuberculosis and other mycobacterial diseases, and important tools both in antimycobacterial drug development and basic research in mycobacterial pathogenesis. Recombinant mycobacteria that stably overexpress and secrete major extracellular proteins of M. tuberculosis in native form on plasmids pSMT3 and pNBV1 were previously constructed by the authors. To enhance the versatility of this plasmid-based approach for mycobacterial protein expression, the Escherichi

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Chilima, Benson Z., Ian M. Clark, Sian Floyd, Paul E. M. Fine, and Penny R. Hirsch. "Distribution of Environmental Mycobacteria in Karonga District, Northern Malawi." Applied and Environmental Microbiology 72, no. 4 (2006): 2343–50. http://dx.doi.org/10.1128/aem.72.4.2343-2350.2006.

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ABSTRACT The genus Mycobacterium includes many species that are commonly found in the environment (in soil and water or associated with plants and animals), as well as species that are responsible for two major human diseases, tuberculosis (Mycobacterium tuberculosis) and leprosy (Mycobacterium leprae). The distribution of environmental mycobacteria was investigated in the context of a long-term study of leprosy, tuberculosis, Mycobacterium bovis BCG vaccination, and the responses of individuals to various mycobacterial antigens in Karonga District, northern Malawi, where epidemiological studi

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Fol, Marek, Piotr Koziński, Jakub Kulesza, Piotr Białecki, and Magdalena Druszczyńska. "Dual Nature of Relationship between Mycobacteria and Cancer." International Journal of Molecular Sciences 22, no. 15 (2021): 8332. http://dx.doi.org/10.3390/ijms22158332.

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Although the therapeutic effect of mycobacteria as antitumor agents has been known for decades, recent epidemiological and experimental studies have revealed that mycobacterium-related chronic inflammation may be a possible mechanism of cancer pathogenesis. Mycobacterium tuberculosis and non-tuberculous Mycobacterium avium complex infections have been implicated as potentially contributing to the etiology of lung cancer, whereas Mycobacterium ulcerans has been correlated with skin carcinogenesis. The risk of tumor development with chronic mycobacterial infections is thought to be a result of m

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6

Kelley, Victoria A., and Jeffrey S. Schorey. "Mycobacterium's Arrest of Phagosome Maturation in Macrophages Requires Rab5 Activity and Accessibility to Iron." Molecular Biology of the Cell 14, no. 8 (2003): 3366–77. http://dx.doi.org/10.1091/mbc.e02-12-0780.

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Many mycobacteria are intramacrophage pathogens that reside within nonacidified phagosomes that fuse with early endosomes but do not mature to phagolysosomes. The mechanism by which mycobacteria block this maturation process remains elusive. To gain insight into whether fusion with early endosomes is required for mycobacteria-mediated inhibition of phagosome maturation, we investigated how perturbing the GTPase cycles of Rab5 and Rab7, GTPases that regulate early and late endosome fusion, respectively, would affect phagosome maturation. Retroviral transduction of the constitutively activated f

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Cayer, Marie-Pierre, Marc Veillette, Pascal Pageau, et al. "Identification of mycobacteria in peat moss processing plants: application of molecular biology approaches." Canadian Journal of Microbiology 53, no. 1 (2007): 92–99. http://dx.doi.org/10.1139/w06-105.

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Peat moss processing plant workers are exposed to high concentrations of bioaerosols. Although mycobacteria have been cultured from peat moss, no study has examined the workers' exposure to mycobacterial bioaerosols. We evaluated the presence of mycobacteria in air samples from peat moss processing plants using molecular biology approaches (cloning-sequencing and polymerase chain reaction (PCR)) and the workers exposure using immunoglobulin G (IgG) complexes to mycobacteria. In addition, species detected in air samples and in peat moss were compared. Two peat moss processing plants were chosen

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Tiwari, Mohit Kumar, and Pratibha Gupta. "In vitro Study on, Effect of Anti Tubercular Drugs on Mycobacterium Lucknowense, sp. nov. Isolated from Indian Frog Rana Tigerina." Anusandhaan - Vigyaan Shodh Patrika 8, no. 1 (2020): 49–53. https://doi.org/10.22445/avsp.v8i1.8.

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Mycobacteria are the bacilli responsible for causing tuberculosis and leprosy like diseases. Tuberculosis is a important global problem, caused by Mycobacterium tuberculosis. Interrupted chemotherapy led to spread of drug resistant mycobacterial infections, which is now most burning problem all over the world. A typical Mycobacteria and other members of genus which can cause typical tuberculosis like symptoms and extra pulmonary mycobacterial infections in almost all parts of human body and also in other animals from Pisces, Reptiles, Birds and Mammalia. Infected man can spread disease in anim

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Mah, Nancy, Carolina Perez-Iratxeta, and Miguel A. Andrade-Navarro. "Outer membrane pore protein prediction in mycobacteria using genomic comparison." Microbiology 156, no. 8 (2010): 2506–15. http://dx.doi.org/10.1099/mic.0.040089-0.

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Proteins responsible for outer membrane transport across the unique membrane structure of Mycobacterium spp. are attractive drug targets in the treatment of human diseases caused by the mycobacterial pathogens, Mycobacterium tuberculosis, M. bovis, M. leprae and M. ulcerans. In contrast with Escherichia coli, relatively few outer-membrane proteins (OMPs) have been identified in Mycobacterium spp., largely due to the difficulties in isolating mycobacterial membrane proteins and our incomplete understanding of secretion mechanisms and cell wall structure in these organisms. To further expand our

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Durnez, Lies, Miriam Eddyani, Georgies F. Mgode, et al. "First Detection of Mycobacteria in African Rodents and Insectivores, Using Stratified Pool Screening." Applied and Environmental Microbiology 74, no. 3 (2007): 768–73. http://dx.doi.org/10.1128/aem.01193-07.

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ABSTRACT With the rising number of patients with human immunodeficiency virus (HIV)/AIDS in developing countries, the control of mycobacteria is of growing importance. Previous studies have shown that rodents and insectivores are carriers of mycobacteria. However, it is not clear how widespread mycobacteria are in these animals and what their role is in spreading them. Therefore, the prevalence of mycobacteria in rodents and insectivores was studied in and around Morogoro, Tanzania. Live rodents were trapped, with three types of live traps, in three habitats. Pieces of organs were pooled per h

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Mamilla, Divya, Stevephen Hung, Gizachew Demessie, et al. "Growth Media on Performance of Mycobacteria Identification Using Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry." LabMed 2, no. 2 (2025): 6. https://doi.org/10.3390/labmed2020006.

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Identification of mycobacterial infections for both Mycobacterium tuberculosis and non-tuberculosis mycobacteria is important for effective patient care. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) is a promising tool that is used in many clinical laboratories for the identification of bacteria and yeast. This study evaluates the impact of growth media on the performance of the MALDI Biotyper® MBT smart MS for mycobacteria identification. Increased rates of identification, particularly in non-rapid growers and pigment producers, and higher confid

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Zavgorodniy, A. I., S. A. Pozmogova, and M. V. Kalashnyk. "Domestic parrots as a potential source of Mycobacteriosis." Journal for Veterinary Medicine, Biotechnology and Biosafety 6, no. 2 (2020): 5–8. http://dx.doi.org/10.36016/jvmbbs-2020-6-2-1.

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The article presents the results of bacteriological examination of five samples of feces from grey parrots (Psittacus) (n = 3), cockatoo (Cacatua) (n = 1), yellow-crowned amazon (Amazona) (n = 1). Five cultures of mycobacteria were bacteriologically isolated from the five samples. According to biochemical and cultural-morphological characteristics, mycobacterial cultures are classified as Mycobacterium scrofulaceum (n = 1) and Mycobacterium genavense (n = 4). Isolated cultures of mycobacteria are important in human pathology. Infected exotic poultry pose a potential risk of mycobacterial infec

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Le Dantec, Corinne, Jean-Pierre Duguet, Antoine Montiel, Nadine Dumoutier, Sylvie Dubrou, and Véronique Vincent. "Occurrence of Mycobacteria in Water Treatment Lines and in Water Distribution Systems." Applied and Environmental Microbiology 68, no. 11 (2002): 5318–25. http://dx.doi.org/10.1128/aem.68.11.5318-5325.2002.

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ABSTRACT The frequency of recovery of atypical mycobacteria was estimated in two treatment plants providing drinking water to Paris, France, at some intermediate stages of treatment. The two plants use two different filtration processes, rapid and slow sand filtration. Our results suggest that slow sand filtration is more efficient for removing mycobacteria than rapid sand filtration. In addition, our results show that mycobacteria can colonize and grow on granular activated carbon and are able to enter distribution systems. We also investigated the frequency of recovery of mycobacteria in the

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Chin, Kai Ling. "Molecular Characterization of Mycobacterium species Isolates from Patients with Pulmonary Tuberculosis in Sabah, Malaysia." Medicine & Health 17, no. 1 (2022): 198–210. http://dx.doi.org/10.17576/mh.2022.1701.15.

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Tuberculosis (TB) is one of the deadliest diseases worldwide, caused by members of Mycobacterium tuberculosis complex (MTBC), commonly by Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis. In Malaysia, Sabah is one of the states of public health concern with the highest TB cases. Clinical presentations of TB and non-tuberculous mycobacteria (NTM) lung disease are similar, and mycobacteria appear to be identical under standard diagnosis with sputum smear microscopy, causing difficulty to diagnose TB. Identification of Mycobacterium species is essential for effective management of mycobac

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Inoue, Hiroyuki, Naoki Washida, Kohkichi Morimoto, et al. "Non-Tuberculous Mycobacterial Infections Related to Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 38, no. 2 (2017): 147–49. http://dx.doi.org/10.3747/pdi.2017.00172.

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Most infections related to peritoneal dialysis (PD) are caused by common bacteria, and non-tuberculous mycobacteria are rare. The clinical characteristics and prognosis of PD patients with non-tuberculous mycobacterial infections were investigated at our hospital. Non-tuberculous mycobacteria were detected in 11 patients (exit-site infection, tunnel infection, and peritonitis in 3, 5, and 3 patients, respectively). Mycobacterium fortuitum, Mycobacterium chelonae, and Mycobacterium abscessus were identified in 4, 2, and 2 patients, respectively. Most patients with peritonitis or tunnel infectio

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Falkinham, Joseph O., Cheryl D. Norton, and Mark W. LeChevallier. "Factors Influencing Numbers of Mycobacterium avium, Mycobacterium intracellulare, and Other Mycobacteria in Drinking Water Distribution Systems." Applied and Environmental Microbiology 67, no. 3 (2001): 1225–31. http://dx.doi.org/10.1128/aem.67.3.1225-1231.2001.

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ABSTRACT Eight water distribution systems were sampled over an 18-month period (528 water and 55 biofilm samples) to measure the frequency of recovery and number of mycobacteria, particularly Mycobacterium avium and Mycobacterium intracellulare, in raw source waters before and after treatment and within the distribution system. The systems were chosen to assess the influence of source water, treatment, and assimilable organic carbon levels on mycobacterial numbers. Overall, mycobacterial recovery from the systems was low (15% of samples). Numbers of mycobacteria ranged from 10 to 700,000 CFU l

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DIDKOWSKA, ANNA, PIOTR ŻMUDA, BLANKA ORŁOWSKA, and KRZYSZTOF ANUSZ. "Mycobacterial infections in cats (Felis catus) as a potential threat to humans – a review 2014–2023." Medycyna Weterynaryjna 79, no. 12 (2023): 6842–2023. http://dx.doi.org/10.21521/mw.6842.

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Mycobacteria infections in cats include tuberculosis (caused by Mycobacterium bovis and Mycobacterium microti) and mycobacteriosis caused by non-tuberculous mycobacteria (NTM). The aim of the paper is to present the latest reports on mycobacterial infections in cats and place emphasis on their impact on the health of their owners. The reviewers looked for papers about mycobacterial infections in cats in PubMed and Google Scholar from any date from January 2014 to June 2023. The search used the following keywords: cat, feline, tuberculosis, and mycobacteria. Papers were evaluated for their valu

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Orumwense, Pedro Osagie, Eila Torvinen, and Helvi Heinonen-Tanski. "The survival of mycobacteria in pure human urine." Water Science and Technology 67, no. 8 (2013): 1773–77. http://dx.doi.org/10.2166/wst.2013.052.

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Mycobacterial pathogens can be excreted in human urine by some infected individuals. High numbers of pathogenic mycobacteria in the urine could represent a new transmission route for mycobacterial infections if the urine is used for crop fertilization. In this study, the survival of spiked Mycobacterium aurum and M. fortuitum as fast-growing mycobacteria and M. avium and M. bovis as slow-growing mycobacteria were tested in urine. The tests were conducted in fresh (&lt;1 day old) and stored human urine (&gt;6 months old) at temperatures of 15 and 30 °C. The results indicate that these m

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De Groote, Mary Ann, Norman R. Pace, Kayte Fulton, and Joseph O. Falkinham. "Relationships between Mycobacterium Isolates from Patients with Pulmonary Mycobacterial Infection and Potting Soils." Applied and Environmental Microbiology 72, no. 12 (2006): 7602–6. http://dx.doi.org/10.1128/aem.00930-06.

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ABSTRACT High numbers of mycobacteria, including known pathogenic species such as Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium chelonae, were recovered from aerosols produced by pouring commercial potting soil products and potting soil samples provided by patients with pulmonary mycobacterial infections. The dominant mycobacteria in the soil samples corresponded to the dominant species implicated clinically. Profiles of large restriction fragments obtained by pulsed-field gel electrophoresis demonstrated a closely related pair of M. avium isolates recovered from a patie

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Julien, Coulibaly Kalpy, Vakou N’dri Sabine, Kouakou Luc Venance, et al. "Phylogenetic Profile of Nonulcerans and Nontuberculous Environmental Mycobacteria Isolated in Côte d’Ivoire." International Journal of Mycobacteriology 13, no. 2 (2024): 158–64. http://dx.doi.org/10.4103/ijmy.ijmy_96_24.

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Background: Environmental mycobacteria are involved in several infections ranging from lung to skin infections. In Côte d’Ivoire, apart from Mycobacterium ulcerans and Mycobacterium tuberculosis, little information exists on other species. The culture of these species, a real challenge, especially in developing countries like Cote d’Ivoire, limits their identification. However, there are reports in literature of infections caused by these mycobacteria, and few species have never been described in human or animal infections. These are difficult cases to treat because of their resistance to most

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Armianinova, D. K., D. S. Karpov, M. S. Kotliarova, and A. V. Goncharenko. "Genetic Engineering in Mycobacteria." Molecular Biology 56, no. 6 (2022): 830–41. http://dx.doi.org/10.1134/s0026893322060036.

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Abstract Genetic tools for targeted modification of the mycobacterial genome contribute to the understanding of the physiology and virulence mechanisms of mycobacteria. Human and animal pathogens, such as the Mycobacterium tuberculosis complex, which causes tuberculosis, and M. leprae, which causes leprosy, are of particular importance. Genetic research opens up novel opportunities to identify and validate new targets for antibacterial drugs and to develop improved vaccines. Although mycobacteria are difficult to work with due to their slow growth rate and a limited possibility to transfer gen

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Aspatwar, Ashok, Jean-Yves Winum, Fabrizio Carta та ін. "Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies". Molecules 23, № 11 (2018): 2911. http://dx.doi.org/10.3390/molecules23112911.

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Mycobacteria cause a variety of diseases, such as tuberculosis, leprosy, and opportunistic diseases in immunocompromised people. The treatment of these diseases is problematic, necessitating the development of novel treatment strategies. Recently, β-carbonic anhydrases (β-CAs) have emerged as potential drug targets in mycobacteria. The genomes of mycobacteria encode for three β-CAs that have been cloned and characterized from Mycobacterium tuberculosis (Mtb) and the crystal structures of two of the enzymes have been determined. Different classes of inhibitor molecules against Mtb β-CAs have su

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Davis, William C., Gaber S. Abdellrazeq, Asmaa H. Mahmoud, et al. "Advances in Understanding of the Immune Response to Mycobacterial Pathogens and Vaccines through Use of Cattle and Mycobacterium avium subsp. paratuberculosis as a Prototypic Mycobacterial Pathogen." Vaccines 9, no. 10 (2021): 1085. http://dx.doi.org/10.3390/vaccines9101085.

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Lack of understanding of the immune response to mycobacterial pathogens has impeded progress in development of vaccines. Infection leads to development of an immune response that controls infection but is unable to eliminate the pathogen, resulting in a persistent infection. Although this puzzle remains to be solved, progress has been made using cattle as a model species to study the immune response to a prototypic mycobacterium, Mycobacterium a. paratuberculosis (Map). As chronicled in the review, incremental advances in characterizing the immune response to mycobacteria during the last 30 ye

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Pagán-Ramos, E., J. Song, M. McFalone, M. H. Mudd, and V. Deretic. "Oxidative Stress Response and Characterization of theoxyR-ahpC and furA-katG Loci inMycobacterium marinum." Journal of Bacteriology 180, no. 18 (1998): 4856–64. http://dx.doi.org/10.1128/jb.180.18.4856-4864.1998.

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ABSTRACT Oxidative stress response in pathogenic mycobacteria is believed to be of significance for host-pathogen interactions at various stages of infection. It also plays a role in determining the intrinsic susceptibility to isoniazid in mycobacterial species. In this work, we characterized the oxyR-ahpC and furA-katG loci in the nontuberculous pathogen Mycobacterium marinum. In contrast to Mycobacterium smegmatis and likeMycobacterium tuberculosis and Mycobacterium leprae, M. marinum was shown to possess a closely linked and divergently oriented equivalents of the regulator of peroxide stre

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Bashyam, Murali D., and Anil K. Tyagi. "Identification and Analysis of “Extended −10” Promoters from Mycobacteria." Journal of Bacteriology 180, no. 9 (1998): 2568–73. http://dx.doi.org/10.1128/jb.180.9.2568-2573.1998.

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ABSTRACT Earlier studies from our laboratory on randomly isolated transcriptional signals of mycobacteria had revealed that the −10 region of mycobacterial promoters and the corresponding binding domain in the major sigma factor are highly similar to their Escherichia coli counterparts. In contrast, the sequences in −35 regions of mycobacterial promoters and the corresponding binding domain in the major sigma factor are vastly different from their E. colicounterparts (M. D. Bashyam, D. Kaushal, S. K. Dasgupta, and A. K. Tyagi, J. Bacteriol. 178:4847–4853, 1996). We have now analyzed the role o

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Av-Gay, Yossef, and Rafat Sobouti. "Cholesterol is accumulated by mycobacteria but its degradation is limited to non-pathogenic fast-growing mycobacteria." Canadian Journal of Microbiology 46, no. 9 (2000): 826–31. http://dx.doi.org/10.1139/w00-060.

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In this report we show that fast-growing non-pathogenic mycobacteria degrade cholesterol from liquid media, and are able to grow on cholesterol as a sole carbon source. In contrast, slow-growing mycobacteria, including pathogenic Mycobacterium tuberculosis and bacillus Calmette-Guérin (BCG), do not degrade and use cholesterol as a carbon source. Nevertheless, pathogenic mycobacteria are able to uptake, modify, and accumulate cholesterol from liquid growth media, and form a zone of clearance around a colony when plated on solid media containing cholesterol. These data suggest that cholesterol m

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Galassi, L., R. Donato, E. Tortoli, D. Burrini, D. Santianni, and R. Dei. "Nontuberculous mycobacteria in hospital water systems: application of HPLC for identification of environmental mycobacteria." Journal of Water and Health 1, no. 3 (2003): 133–39. http://dx.doi.org/10.2166/wh.2003.0016.

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Nontuberculous mycobacteria (NTM), ubiquitous in water environments, are increasingly recognized as nosocomial pathogens. Our study reports a one-year survey of the water system of two hospitals, A and B, in a small town near Florence, Italy. NTM were found throughout the study period in both settings, but B showed a significantly higher mycobacterial load. Mycobacterium gordonae and Mycobacterium fortuitum were the most frequent species isolated. Identification was carried out by conventional techniques and by high performance liquid chromatography (HPLC) analysis of cell wall mycolic acids.

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Fineran, Paul, Emyr Lloyd-Evans, Nathan A. Lack, et al. "Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway." Wellcome Open Research 1 (November 18, 2016): 18. http://dx.doi.org/10.12688/wellcomeopenres.10036.1.

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Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term persistence within host cells. The mechanisms underpinning this key intracellular pro-survival strategy remain incompletely understood. Host macrophages infected with persistent mycobacteria share phenotypic similarities with cells taken from patients suffering from Niemann-Pick Disease Type C (NPC), a rare lysosomal storage disease in which endocytic trafficking defects a

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Fineran, Paul, Emyr Lloyd-Evans, Nathan A. Lack, et al. "Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway." Wellcome Open Research 1 (June 21, 2017): 18. http://dx.doi.org/10.12688/wellcomeopenres.10036.2.

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Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term persistence within host cells. The mechanisms underpinning this key intracellular pro-survival strategy remain incompletely understood. Host macrophages infected with intracellular mycobacteria share phenotypic similarities with cells taken from patients suffering from Niemann-Pick Disease Type C (NPC), a rare lysosomal storage disease in which endocytic trafficking defect

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Soini, Hanna, and James M. Musser. "Molecular Diagnosis of Mycobacteria." Clinical Chemistry 47, no. 5 (2001): 809–14. http://dx.doi.org/10.1093/clinchem/47.5.809.

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Abstract Tuberculosis is one of the leading infectious diseases in the world and is responsible for more than 2 million deaths and 8 million new cases annually. Because of the slow growth rate of the causative agent Mycobacterium tuberculosis, isolation, identification, and drug susceptibility testing of this organism and other clinically important mycobacteria can take several weeks or longer. During the past several years, many molecular methods have been developed for direct detection, species identification, and drug susceptibility testing of mycobacteria. These methods can potentially red

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Caire-Brändli, Irène, Alexia Papadopoulos, Wladimir Malaga, et al. "Reversible Lipid Accumulation and Associated Division Arrest of Mycobacterium avium in Lipoprotein-Induced Foamy Macrophages May Resemble Key Events during Latency and Reactivation of Tuberculosis." Infection and Immunity 82, no. 2 (2013): 476–90. http://dx.doi.org/10.1128/iai.01196-13.

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ABSTRACTDuring the dormant phase of tuberculosis,Mycobacterium tuberculosispersists in lung granulomas by residing in foamy macrophages (FM) that contain abundant lipid bodies (LB) in their cytoplasm, allowing bacilli to accumulate lipids as intracytoplasmic lipid inclusions (ILI). An experimental model of FM is presented where bone marrow-derived mouse macrophages are infected withM. aviumand exposed to very-low-density lipoprotein (VLDL) as a lipid source. Quantitative analysis of detailed electron microscope observations showed the following results. (i) Macrophages became foamy, and mycoba

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Torvinen, Eila, Sini Suomalainen, Markku J. Lehtola, et al. "Mycobacteria in Water and Loose Deposits of Drinking Water Distribution Systems in Finland." Applied and Environmental Microbiology 70, no. 4 (2004): 1973–81. http://dx.doi.org/10.1128/aem.70.4.1973-1981.2004.

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ABSTRACT Drinking water distribution systems were analyzed for viable counts of mycobacteria by sampling water from waterworks and in different parts of the systems. In addition, loose deposits collected during mechanical cleaning of the main pipelines were similarly analyzed. The study covered 16 systems at eight localities in Finland. In an experimental study, mycobacterial colonization of biofilms on polyvinyl chloride tubes in a system was studied. The isolation frequency of mycobacteria increased from 35% at the waterworks to 80% in the system, and the number of mycobacteria in the positi

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Tzanatou, A., D. Papaventsis, G. Vrioni, and J. Papaparaskevas. "Applications of MALDI-TOF mass spectrometry in the diagnosis of mycobacterial infections." ACTA MICROBIOLOGICA HELLENICA 68, no. 4 (2023): 215–29. https://doi.org/10.5281/zenodo.10203252.

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The genus Mycobacterium includes species like the members of the pathogenic Mycobacterium tuberculosis complex, a major global public health burden, and an ever-increasing number of nontuberculous mycobacterial species, of which approximately 1/3 have been associated with infections linked to substantial morbidity and mortality. Therefore, the rapid and accurate identification of mycobacteria is crucial for disease management.MALDI-TOF MS technique was introduced for the identification of microorganisms as a common laboratory practice during the last decade. It utilizes the unique for each spe

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Hosseiniporgham, Sepideh, and Leonardo A. Sechi. "A Review on Mycobacteriophages: From Classification to Applications." Pathogens 11, no. 7 (2022): 777. http://dx.doi.org/10.3390/pathogens11070777.

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Mycobacterial infections are a group of life-threatening conditions triggered by fast- or slow-growing mycobacteria. Some mycobacteria, such as Mycobacterium tuberculosis, promote the deaths of millions of lives throughout the world annually. The control of mycobacterial infections is influenced by the challenges faced in the diagnosis of these bacteria and the capability of these pathogens to develop resistance against common antibiotics. Detection of mycobacterial infections is always demanding due to the intracellular nature of these pathogens that, along with the lipid-enriched structure o

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Opperman, Christoffel Johannes, and Adrian J. Brink. "Phage Therapy for Mycobacteria: Overcoming Challenges, Unleashing Potential." Infectious Disease Reports 17, no. 2 (2025): 24. https://doi.org/10.3390/idr17020024.

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Bacteriophage (phage) therapy is emerging as a promising alternative to traditional antibiotics for treating drug-resistant mycobacterial infections, including Mycobacterium tuberculosis complex (MTBC) and non-tuberculous mycobacteria (NTM) [...]

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Sriruan, Chanjuti, Watchara Kasinrerk, Sorasak Intorasoot, et al. "Identification and monitoring of Mycobacterium tuberculosis growth in liquid culture by Antigen 85 detection." Journal of Associated Medical Sciences 55, no. 3 (2022): 96–104. http://dx.doi.org/10.12982/jams.2022.030.

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Background: Mycobacterium tuberculosis is the most common causative agent of tuberculosis. It releases secretory proteins, especially the Ag85 complex, from actively growing mycobacteria, which can be detected in mycobacterial liquid culture. Ag85B is the most abundant in the Ag85 complex and is an interesting target for the detection of tuberculosis. In addition, measuring Ag85 level is beneficial for comparing growing and non-growing mycobacteria in liquid culture. Objectives: To detect Ag85B protein from active growing M. tuberculosis in liquid culture for the diagnosis of tuberculosis and

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Miller, Nancimae, Susanna Infante, and Tim Cleary. "Evaluation of the LiPA MYCOBACTERIA Assay for Identification of Mycobacterial Species from BACTEC 12B Bottles." Journal of Clinical Microbiology 38, no. 5 (2000): 1915–19. http://dx.doi.org/10.1128/jcm.38.5.1915-1919.2000.

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The LiPA MYCOBACTERIA (Innogenetics NV, Ghent, Belgium) assay was used to identify mycobacterial isolates using culture fluid from positive BACTEC 12B bottles. The LiPA method involves reverse hybridization of a biotinylated mycobacterial PCR fragment, a 16 to 23S rRNA spacer region, to oligonucleotide probes arranged in lines on a membrane strip, with detection via biotin-streptavidin coupling by a colorimetric system. This system identifies Mycobacteriumspecies and differentiates M. tuberculosis complex,M. avium-M. intracellulare complex, and the following mycobacterial species: M. avium, M.

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Pavlik, Ivo, Vit Ulmann, Dana Hubelova, and Ross Tim Weston. "Nontuberculous Mycobacteria as Sapronoses: A Review." Microorganisms 10, no. 7 (2022): 1345. http://dx.doi.org/10.3390/microorganisms10071345.

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Mycobacteria are a unique group of microorganisms. They are characterised by exceptional adaptability and durability. They are capable of colonisation and survival even in very unfavourable conditions. In addition to the well-known obligate human pathogens, Mycobacterium tuberculosis and M. leprae, more than 200 other species have been described. Most of them form a natural part of the microflora of the external environment and thrive in aquatic and soil environments especially. For many of the mycobacterial species associated with human disease, their natural source has not yet been identifie

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Qadri, S. M. Hussain, and Kevin K. Smith. "Nonspecificity of the Anda A60-tb ELISA test for serodiagnosis of mycobacterial disease." Canadian Journal of Microbiology 38, no. 8 (1992): 804–6. http://dx.doi.org/10.1139/m92-131.

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The conventional methods for the laboratory diagnosis of tuberculosis and other mycobacterial diseases are time consuming and beyond the scope of most of the small and medium-sized hospital facilities. Therefore, there has been considerable interest in the development of a serological method for the detection of antibodies against mycobacteria. We recently evaluated a commercially available ELISA test (Anda Biologicals, Strasbourg, France) that measures antibody levels to A60 antigen, a membrane glycoprotein that is found in most mycobacteria. Of the 123 patients with positive pulmonary cultur

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Torkko, Pirjo, Marja-Leena Katila, and Merja Kontro. "Gas-chromatographic lipid profiles in identification of currently known slowly growing environmental mycobacteria." Journal of Medical Microbiology 52, no. 4 (2003): 315–23. http://dx.doi.org/10.1099/jmm.0.05113-0.

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Cellular fatty acid analysis by GLC is widely used in the species identification of mycobacteria. Combining mycolic acid cleavage products with shorter cellular fatty acids increases the informative value of the analysis. A key has been created to aid in the identification of all currently known slowly growing environmental species. In this scheme, the species are classified into six categories, each characterized by a combination of fatty markers shared by those species. Within each category, individual species may be distinguished by the presence or absence of specific marker substances, suc

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Gan, Wei Chong, Hien Fuh Ng, and Yun Fong Ngeow. "Mechanisms of Linezolid Resistance in Mycobacteria." Pharmaceuticals 16, no. 6 (2023): 784. http://dx.doi.org/10.3390/ph16060784.

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Mycobacteria form some of the most notorious and difficult-to-treat bacterial pathogens. As a group, they are intrinsically resistant to many commonly used antibiotics, such as tetracyclines and beta-lactams. In addition to intrinsic resistances, acquired multidrug resistance has also been observed and documented in Mycobacterium tuberculosis (MTB), Mycobacterium leprae and non-tuberculous mycobacteria (NTM). To combat multidrug resistant infections by these pathogens, innovative antimicrobials and treatment regimens are required. In this regard, linezolid, an oxazolidinone introduced for clin

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Seagar, A. Louise, Carmel Prendergast, F. Xavier Emmanuel, Alan Rayner, Susan Thomson, and Ian F. Laurenson. "Evaluation of the GenoType Mycobacteria Direct assay for the simultaneous detection of the Mycobacterium tuberculosis complex and four atypical mycobacterial species in smear-positive respiratory specimens." Journal of Medical Microbiology 57, no. 5 (2008): 605–11. http://dx.doi.org/10.1099/jmm.0.47484-0.

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A novel, commercially available reverse hybridization assay [GenoType Mycobacteria Direct (GTMD), version 2.0; Hain Lifescience] was evaluated for the direct detection of five clinically relevant mycobacterial species [Mycobacterium tuberculosis complex (MTBC), Mycobacterium avium, Mycobacterium malmoense, Mycobacterium kansasii and Mycobacterium intracellulare] from 54 smear-positive respiratory specimens and the findings were compared with culture results. Three approaches were used for specimen preparation using either whole or ‘split’ sample volumes and N-acetyl-l-cysteine/3 % NaOH or 4 %

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Menendez, M. C., M. J. Garcia, M. C. Navarro, et al. "Characterization of an rRNA Operon (rrnB) of Mycobacterium fortuitum and Other Mycobacterial Species: Implications for the Classification of Mycobacteria." Journal of Bacteriology 184, no. 4 (2002): 1078–88. http://dx.doi.org/10.1128/jb.184.4.1078-1088.2002.

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ABSTRACT Mycobacteria are thought to have either one or two rRNA operons per genome. All mycobacteria investigated to date have an operon, designated rrnA, located downstream from the murA gene. We report that Mycobacteriun fortuitum has a second rrn operon, designated rrnB, which is located downstream from the tyrS gene; tyrS is very close to the 3" end of a gene (3-mag) coding for 3-methylpurine-DNA-glycosylase. The second rrn operon of Mycobacterium smegmatis was shown to have a similar organization, namely, 5" 3-mag-tyrS-rrnB 3". The rrnB operon of M. fortuitum was found to have a single d

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Banducci-Karp, Adrianna, Jiajun Xie, Sem A. G. Engels, et al. "DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages." Cells 12, no. 6 (2023): 828. http://dx.doi.org/10.3390/cells12060828.

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Damage-Regulated Autophagy Modulator 1 (DRAM1) is an infection-inducible membrane protein, whose function in the immune response is incompletely understood. Based on previous results in a zebrafish infection model, we have proposed that DRAM1 is a host resistance factor against intracellular mycobacterial infection. To gain insight into the cellular processes underlying DRAM1-mediated host defence, here we studied the interaction of DRAM1 with Mycobacterium marinum in murine RAW264.7 macrophages. We found that, shortly after phagocytosis, DRAM1 localised in a punctate pattern to mycobacteria,

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Rindi, Laura, Vincenzo Puglisi, Iacopo Franconi, Roberta Fais, and Antonella Lupetti. "Rapid and Accurate Identification of Nontuberculous Mycobacteria Directly from Positive Primary MGIT Cultures by MALDI-TOF MS." Microorganisms 10, no. 7 (2022): 1447. http://dx.doi.org/10.3390/microorganisms10071447.

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Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Accurate and rapid mycobacterial species identification is needed to successfully diagnose, treat, and manage infections caused by NTM. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, MALDI-TOF MS, was demonstrated to effectively identify mycobacteria isolates subcultured from solid or liquid media rather than new positive cultures. The present study aims to develop a new extraction protocol to yield rapid and accurate identification of NTM from primary MGIT cultures

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Ufimtseva, Elena. "Differences betweenMycobacterium-Host Cell Relationships in Latent Tuberculous Infection of MiceEx Vivoand Mycobacterial Infection of Mouse CellsIn Vitro." Journal of Immunology Research 2016 (2016): 1–21. http://dx.doi.org/10.1155/2016/4325646.

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The search for factors that account for the reproduction and survival of mycobacteria, including vaccine strains, in host cells is the priority for studies on tuberculosis. A comparison of BCG-mycobacterial loads in granuloma cells obtained from bone marrow and spleens of mice with latent tuberculous infection and cells from mouse bone marrow and peritoneal macrophage cultures infected with the BCG vaccinein vitrohas demonstrated that granuloma macrophages each normally contained a single BCG-Mycobacterium, while those acutely infectedin vitrohad increased mycobacterial loads and death rates.

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Sethiya, Jigar P., Melanie A. Sowards, Mary Jackson, and Elton Jeffrey North. "MmpL3 Inhibition: A New Approach to Treat Nontuberculous Mycobacterial Infections." International Journal of Molecular Sciences 21, no. 17 (2020): 6202. http://dx.doi.org/10.3390/ijms21176202.

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Outside of Mycobacterium tuberculosis and Mycobacterium leprae, nontuberculous mycobacteria (NTM) are environmental mycobacteria (>190 species) and are classified as slow- or rapid-growing mycobacteria. Infections caused by NTM show an increased incidence in immunocompromised patients and patients with underlying structural lung disease. The true global prevalence of NTM infections remains unknown because many countries do not require mandatory reporting of the infection. This is coupled with a challenging diagnosis and identification of the species. Current therapies for treatment of NTM i

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Vieira, Otilia V., Rene E. Harrison, Cameron C. Scott, et al. "Acquisition of Hrs, an Essential Component of Phagosomal Maturation, Is Impaired by Mycobacteria." Molecular and Cellular Biology 24, no. 10 (2004): 4593–604. http://dx.doi.org/10.1128/mcb.24.10.4593-4604.2004.

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ABSTRACT Pathogenic mycobacteria survive within macrophages by precluding the fusion of phagosomes with late endosomes or lysosomes. Because the molecular determinants of normal phagolysosome formation are poorly understood, the sites targeted by mycobacteria remain unidentified. We found that Hrs, an adaptor molecule involved in protein sorting, associates with phagosomes prior to their fusion with late endosomes or lysosomes. Recruitment of Hrs required the interaction of its FYVE domain with phagosomal phosphatidylinositol 3-phosphate, but two other attachment sites were additionally involv

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Vadankula, Govinda Raju, Arshad Rizvi, Haider Ali, et al. "Secondary Metabolites from a New Antibiotic-Producing Endophytic Streptomyces Isolate Inhibited Pathogenic and Multidrug-Resistant Mycobacterium tuberculosis Strains." Tropical Medicine and Infectious Disease 10, no. 5 (2025): 117. https://doi.org/10.3390/tropicalmed10050117.

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The long regimen of drug therapy, the emergence of drug-resistance (DR), and infections with non-tuberculous mycobacteria (NTMs) are alarming challenges in controlling tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (M.tb), necessitating the pursuit of new, broad-spectrum anti-mycobacterials. With more than two-thirds of the clinically useful antibiotics originating from the bacterial phylum Actinomycetota, and their enormous diversity in India, we explored atypical environments for new bacterial strains with potential anti-M.tb activity. In this study, we the examined the se

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Umpeleva, T. V., S. N. Skornyakov, and D. V. Vakhrusheva. "Biofilms in mycobacterial infection." Clinical Microbiology and Antimicrobial Chemotherapy 26, no. 1 (2024): 14–20. http://dx.doi.org/10.36488/cmac.2024.1.14-20.

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The ability to form biofilms in lung tissue destruction cavities has been described for both the causative agent of tuberculosis (Mycobacterium tuberculosis) and for non-tuberculous mycobacteria. This process is associated with the chronic infection. It is assumed that a change in the biology of the pathogen inside the biofilm (formation of an antibiotic-resistant phenotype) makes ineffective standard chemotherapy regimens, which based on the susceptibility test data of mycobacteria in the “free state”. This review describes the biology of mycobacterial biofilms and the main approaches to comb

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