Academic literature on the topic 'Mycobacterial cell wall biosynthesis inhibitors'

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Journal articles on the topic "Mycobacterial cell wall biosynthesis inhibitors"

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Errey, James C., Giles D. Newbury, Lluis Ballell, and Robert A. Field. "Amino alditols as inhibitors of mycobacterial cell wall biosynthesis." Biochemical Society Transactions 30, no. 1 (2002): A27. http://dx.doi.org/10.1042/bst030a027a.

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Reynolds, Robert C., Namita Bansal, Jerry Rose, Joyce Friedrich, William J. Suling, and Joseph A. Maddry. "Ethambutol–sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis." Carbohydrate Research 317, no. 1-4 (1999): 164–79. http://dx.doi.org/10.1016/s0008-6215(99)00069-5.

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Fu, Jian, Huixiao Fu, Marc Dieu, et al. "Identification of inhibitors targeting Mycobacterium tuberculosis cell wall biosynthesis via dynamic combinatorial chemistry." Chemical Communications 53, no. 77 (2017): 10632–35. http://dx.doi.org/10.1039/c7cc05251k.

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In this study, we report a dynamic combinatorial approach along with highly efficient in situ screening to identify inhibitors of UDP-galactopyranose mutase (UGM), an essential enzyme involved in mycobacterial cell wall biosynthesis.
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Wen, Xianghui, Dean C. Crick, Patrick J. Brennan, and Philip G. Hultin. "Analogues of the mycobacterial arabinogalactan linkage disaccharide as cell wall biosynthesis inhibitors." Bioorganic & Medicinal Chemistry 11, no. 17 (2003): 3579–87. http://dx.doi.org/10.1016/s0968-0896(03)00366-3.

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ABRAHAMS, KATHERINE A., and GURDYAL S. BESRA. "Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target." Parasitology 145, no. 2 (2016): 116–33. http://dx.doi.org/10.1017/s0031182016002377.

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SUMMARYMycobacterium tuberculosis(Mtb), the etiological agent of tuberculosis (TB), is recognized as a global health emergency as promoted by the World Health Organization. Over 1 million deathsperyear, along with the emergence of multi- and extensively-drug resistant strains ofMtb, have triggered intensive research into the pathogenicity and biochemistry of this microorganism, guiding the development of anti-TB chemotherapeutic agents. The essential mycobacterial cell wall, sharing some common features with all bacteria, represents an apparent ‘Achilles heel’ that has been targeted by TB chem
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Nguyen, Liem, Satheesh Chinnapapagari, and Charles J. Thompson. "FbpA-Dependent Biosynthesis of Trehalose Dimycolate Is Required for the Intrinsic Multidrug Resistance, Cell Wall Structure, and Colonial Morphology of Mycobacterium smegmatis." Journal of Bacteriology 187, no. 19 (2005): 6603–11. http://dx.doi.org/10.1128/jb.187.19.6603-6611.2005.

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ABSTRACT Ligation of mycolic acids to structural components of the mycobacterial cell wall generates a hydrophobic, impermeable barrier that provides resistance to toxic compounds such as antibiotics. Secreted proteins FbpA, FbpB, and FbpC attach mycolic acids to arabinogalactan, generating mycolic acid methyl esters (MAME) or trehalose, generating α,α′-trehalose dimycolate (TDM; also called cord factor). Our studies of Mycobacterium smegmatis showed that disruption of fbpA did not affect MAME levels but resulted in a 45% reduction of TDM. The fbpA mutant displayed increased sensitivity to bot
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Lowary, Todd. "Recent Progress Towards the Identification of Inhibitors of Mycobacterial Cell Wall Polysaccharide Biosynthesis." Mini-Reviews in Medicinal Chemistry 3, no. 7 (2003): 689–702. http://dx.doi.org/10.2174/1389557033487683.

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Suthagar, Kajitha, Andrew J. A. Watson, Brendan L. Wilkinson, and Antony J. Fairbanks. "Synthesis of arabinose glycosyl sulfamides as potential inhibitors of mycobacterial cell wall biosynthesis." European Journal of Medicinal Chemistry 102 (September 2015): 153–66. http://dx.doi.org/10.1016/j.ejmech.2015.07.050.

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Wilkinson, Brendan L., Hilary Long, Edith Sim, and Antony J. Fairbanks. "Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis." Bioorganic & Medicinal Chemistry Letters 18, no. 23 (2008): 6265–67. http://dx.doi.org/10.1016/j.bmcl.2008.09.082.

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Rose, Jerry D., Joseph A. Maddry, Robert N. Comber, William J. Suling, Larry N. Wilson, and Robert C. Reynolds. "Synthesis and biological evaluation of trehalose analogs as potential inhibitors of mycobacterial cell wall biosynthesis." Carbohydrate Research 337, no. 2 (2002): 105–20. http://dx.doi.org/10.1016/s0008-6215(01)00288-9.

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Dissertations / Theses on the topic "Mycobacterial cell wall biosynthesis inhibitors"

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May, Terry J. "Synthesis and evaluation of inhibitors of cell wall biosynthesis in Mycobacterium tuberculosis." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/35769/.

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The emergence of drug-resistant strains of tuberculosis has led to a demand for the development of new antibiotics. One new target is the cell wall biosynthesis enzyme UDP-Galp mutase (UGM), which aids the formation of the bacteria’s characteristic mycolic acid cell wall. LQ10 and LQ6 were discovered through a library screen. The synthesis of LQ10 was achieved along with 4 analogues. Another class of compounds, 2-aminothiazoles, were produced. Thirteen of these compounds were produced and along with the LQ10 analogues, initially gave encouraging results in silico. To test their biological acti
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Han, Jeong-Seok. "Studies towards the identification of mycobacterial cell wall biosynthesis inhibitors and synthetic studies of buergerinin F, buergerinin G, and feigrisolide B." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1063903422.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 395 p.; also includes graphics Includes bibliographical references (p. 383-395). Available online via OhioLINK's ETD Center
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Al-Bar, Omar Abdulrahman Mostafa. "Modified amino acids and peptides as potential inhibitors of bacterial cell wall biosynthesis." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303364.

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Umesiri, Francis E. "Synthesis of Carbohydrate-based Inhibitors of Antigen 85." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1282006047.

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Tam, Pui Hang. "Studies of glycosyltransferases involved in mycobacterial cell wall biosynthesis." Phd thesis, 2009. http://hdl.handle.net/10048/627.

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Thesis (Ph. D.)--University of Alberta, 2009.<br>Title from pdf file main screen (viewed on Nov. 25, 2009). "A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Chemistry, University of Alberta." Includes bibliographical references.
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Mortaji, Zahra. "Cellulose biosynthesis inhibitors modulate defense transcripts and regulate genes that are implicated in cell wall re-structuring in arabidopsis." Thesis, 2011. http://hdl.handle.net/10155/161.

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The cell wall is a multifunctional structure which is implicated in plant growth and development as well as responding to any environmental changes including biotic and abiotic stresses. One of the practical approaches in cell wall integrity studies is the modification of the quality and quantity of particular cell wall components or destroying the specific step in cell wall synthesis pathway using Cellulose Biosynthesis Inhibitors (CBIs). In this case, chemical screen for swollen organ phenotype has proved to be an important technique to identify the genes that are directly or indirectly invo
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Books on the topic "Mycobacterial cell wall biosynthesis inhibitors"

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Álvarez, Jesús Miguel. Cellulose biosynthesis inhibitors as tools for research of cell wall structural plasticity. Nova Science Publishers, 2011.

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1935-, Tipper Donald J., ed. Antibiotic inhibitors of bacterial cell wall biosynthesis. Pergamon Press, 1987.

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1935-, Tipper Donald J., ed. Antibiotic inhibitorsof bacterial cell wall biosynthesis. Pergamon, 1987.

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Book chapters on the topic "Mycobacterial cell wall biosynthesis inhibitors"

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Dover, Lynn G., Luke Alderwick, Veemal Bhowruth, Alistair K. Brown, Laurent Kremer, and Gurdyal S. Besra. "Antibiotics and New Inhibitors of the Cell Wall." In The Mycobacterial Cell Envelope. ASM Press, 2014. http://dx.doi.org/10.1128/9781555815783.ch7.

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Gupta, Rani, Namita Gupta, and Shruti Bindal. "Bacterial Cell Wall Biosynthesis and Inhibitors." In Fundamentals of Bacterial Physiology and Metabolism. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0723-3_3.

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Crick, Dean C., Delphi Chatterjee, Michael S. Scherman, and Michael R. McNeil. "Structure and Biosynthesis of the Mycobacterial Cell Wall." In Comprehensive Natural Products II. Elsevier, 2010. http://dx.doi.org/10.1016/b978-008045382-8.00173-8.

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Chopra, Tarun, and Rajesh S. Gokhale. "Chapter 12 Polyketide Versatility in the Biosynthesis of Complex Mycobacterial Cell Wall Lipids." In Methods in Enzymology. Elsevier, 2009. http://dx.doi.org/10.1016/s0076-6879(09)04612-6.

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