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Relevant bibliographies by topics / Mycobacterial Protein Synthesis

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Academic literature on the topic 'Mycobacterial Protein Synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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Journal articles on the topic "Mycobacterial Protein Synthesis"

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Gan, Wei Chong, Hien Fuh Ng, and Yun Fong Ngeow. "Mechanisms of Linezolid Resistance in Mycobacteria." Pharmaceuticals 16, no. 6 (2023): 784. http://dx.doi.org/10.3390/ph16060784.

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Mycobacteria form some of the most notorious and difficult-to-treat bacterial pathogens. As a group, they are intrinsically resistant to many commonly used antibiotics, such as tetracyclines and beta-lactams. In addition to intrinsic resistances, acquired multidrug resistance has also been observed and documented in Mycobacterium tuberculosis (MTB), Mycobacterium leprae and non-tuberculous mycobacteria (NTM). To combat multidrug resistant infections by these pathogens, innovative antimicrobials and treatment regimens are required. In this regard, linezolid, an oxazolidinone introduced for clin

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Rao, Alka, Geeta Ram, Adesh Kumar Saini, et al. "Synthesis and Selection of De Novo Proteins That Bind and Impede Cellular Functions of an Essential Mycobacterial Protein." Applied and Environmental Microbiology 73, no. 4 (2006): 1320–31. http://dx.doi.org/10.1128/aem.02461-06.

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ABSTRACT Recent advances in nonrational and part-rational approaches to de novo peptide/protein design have shown increasing potential for development of novel peptides and proteins of therapeutic use. We demonstrated earlier the usefulness of one such approach recently developed by us, called “codon shuffling,” in creating stand-alone de novo protein libraries from which bioactive proteins could be isolated. Here, we report the synthesis and selection of codon-shuffled de novo proteins that bind to a selected Mycobacterium tuberculosis protein target, the histone-like protein HupB, believed t

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Doherty, T. M., R. J. Booth, S. G. Love, J. J. Gibson, D. R. Harding, and J. D. Watson. "Characterization of an antibody-binding epitope from the 18-kDa protein on Mycobacterium leprae." Journal of Immunology 142, no. 5 (1989): 1691–95. http://dx.doi.org/10.4049/jimmunol.142.5.1691.

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Abstract A murine mAb, designated L5, appears to be specific for an epitope on a protein from Mycobacterium leprae of restricted distribution within the mycobacteria. This protein, of Mr 18,000 (18 kDa) is of interest because monoclonal antibodies raised against it do not appear to cross-react with other mycobacterial pathogens. The L5 antibody-binding epitope has been mapped by two complementary methods; expression of gene fragments and synthesis of short peptides. This L5-binding region of the 18-kDa protein (amino acids 109 to 115) shows some homology to a region of the GroEL heat shock fam

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Rodrigues, José, Vanessa T. Almeida, Ana L. Rosário, et al. "High Throughput Expression Screening of Arabinofuranosyltransferases from Mycobacteria." Processes 9, no. 4 (2021): 629. http://dx.doi.org/10.3390/pr9040629.

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Studies on membrane proteins can help to develop new drug targets and treatments for a variety of diseases. However, membrane proteins continue to be among the most challenging targets in structural biology. This uphill endeavor can be even harder for membrane proteins from Mycobacterium species, which are notoriously difficult to express in heterologous systems. Arabinofuranosyltransferases are involved in mycobacterial cell wall synthesis and thus potential targets for antituberculosis drugs. A set of 96 mycobacterial genes coding for Arabinofuranosyltransferases was selected, of which 17 we

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Driss, Virginie, Fanny Legrand, Emmanuel Hermann та ін. "TLR2-dependent eosinophil interactions with mycobacteria: role of α-defensins". Blood 113, № 14 (2009): 3235–44. http://dx.doi.org/10.1182/blood-2008-07-166595.

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AbstractPeripheral blood and tissue eosinophilia are a prominent feature in allergic diseases and during helminth infections. Eosinophil recruitment also frequently occurs upon mycobacterial infections, particularly in lung granuloma. However, the mechanism by which eosinophils interact with mycobacteria remains largely unknown. Because eosinophils recently have been shown to be involved in innate immune responses, we investigated the direct interactions of eosinophils with Mycobacterium bovis BCG as a study model. We show that live BCG attracts human eosinophils and induces reactive oxygen sp

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Roach, Shannon K., and Jeffrey S. Schorey. "Differential Regulation of the Mitogen-Activated Protein Kinases by Pathogenic and Nonpathogenic Mycobacteria." Infection and Immunity 70, no. 6 (2002): 3040–52. http://dx.doi.org/10.1128/iai.70.6.3040-3052.2002.

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ABSTRACT Mycobacteria are the etiologic agents of numerous diseases which account for significant morbidity and mortality in humans and other animal species. Many mycobacteria are intramacrophage pathogens and therefore the macrophage response to infection, which includes synthesis of cytokines such as tumor necrosis factor alpha (TNF-α) and production of nitric oxide, has important consequences for host immunity. However, very little is known about the macrophage cell signaling pathways initiated upon infection or how pathogenic mycobacteria may modulate the macrophage responses. Using primar

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Mir, Mushtaq, Sladjana Prisic, Choong-Min Kang, et al. "Mycobacterial GenecuvAIs Required for Optimal Nutrient Utilization and Virulence." Infection and Immunity 82, no. 10 (2014): 4104–17. http://dx.doi.org/10.1128/iai.02207-14.

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ABSTRACTTo persist and cause disease in the host,Mycobacterium tuberculosismust adapt to its environment during infection. Adaptations include changes in nutrient utilization and alterations in growth rate.M. tuberculosisRv1422 is a conserved gene of unknown function that was found in a genetic screen to interact with themce4cholesterol uptake locus. The Rv1422 protein is phosphorylated by theM. tuberculosisSer/Thr kinases PknA and PknB, which regulate cell growth and cell wall synthesis.Bacillus subtilisstrains lacking the Rv1422 homologueyvcKgrow poorly on several carbon sources, andyvcKis r

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Gupta, Kuldeepkumar Ramnaresh, Gunjan Arora, Abid Mattoo, and Andaleeb Sajid. "Stringent Response in Mycobacteria: From Biology to Therapeutic Potential." Pathogens 10, no. 11 (2021): 1417. http://dx.doi.org/10.3390/pathogens10111417.

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Mycobacterium tuberculosis is a human pathogen that can thrive inside the host immune cells for several years and cause tuberculosis. This is due to the propensity of M. tuberculosis to synthesize a sturdy cell wall, shift metabolism and growth, secrete virulence factors to manipulate host immunity, and exhibit stringent response. These attributes help M. tuberculosis to manage the host response, and successfully establish and maintain an infection even under nutrient-deprived stress conditions for years. In this review, we will discuss the importance of mycobacterial stringent response under

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Gobala Krishnan P, Gnanaprakash K, and Chandrasekhar KB. "Design, synthesis, characterization and antitubercular activity of some nov-el 2, 4-disubstituted thiazole derivatives." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (2019): 1504–9. http://dx.doi.org/10.26452/ijrps.v10i2.729.

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Literature reviews reveal that thiazole and pyrazine carboxamide derivatives exhibit anticonvulsant, antimicrobial, anticancer and anti-tubercular activities due to the presence of –S-C=N- and-CO–NH- moiety. A series of thiazolyl pyrazine carboxamide derivatives (5a-j) were synthesized by condensation reaction between 2-amino, 4-substituted phenyl 2-amino thiazole and pyrazine 2-carboxylic acid. These synthesized thiazole derivatives (5a-j) were evaluated for their inhibitory activity against Mycobacterium tuberculosis (Mtb), H37Rv using microplate Alamar Blue assay (MABA). The compound, 5c an

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Katsube, Tomoya, Sohkichi Matsumoto, Masaki Takatsuka, et al. "Control of Cell Wall Assembly by a Histone-Like Protein in Mycobacteria." Journal of Bacteriology 189, no. 22 (2007): 8241–49. http://dx.doi.org/10.1128/jb.00550-07.

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ABSTRACT Bacteria coordinate assembly of the cell wall as well as synthesis of cellular components depending on the growth state. The mycobacterial cell wall is dominated by mycolic acids covalently linked to sugars, such as trehalose and arabinose, and is critical for pathogenesis of mycobacteria. Transfer of mycolic acids to sugars is necessary for cell wall biogenesis and is mediated by mycolyltransferases, which have been previously identified as three antigen 85 (Ag85) complex proteins. However, the regulation mechanism which links cell wall biogenesis and the growth state has not been el

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Dissertations / Theses on the topic "Mycobacterial Protein Synthesis"

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Zhang, Guangtao. "Design, synthesis, and evaluation of cholera toxin inhibitors and [alpha]-helix mimetics of dormancy survival regulator /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8485.

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Bruell, Christian M. "Mechanism of protein synthesis in Mycobacterium smegmatis /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17733.

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Berretta, Giacomo. "Total synthesis and semi-synthesis of lipid and protein components of Mycobacterium tuberculosis." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=15583.

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Pheiffer, Carmen. "Investigation of Mycobacterium tuberculosis protein expression and analysis of humoral immune responses of TB patients." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/49999.

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Thesis (PhD)--Stellenbosch University, 2004.<br>ENGLISH ABSTRACT: New agents for the diagnosis, prevention and treatment of tuberculosis are urgently required. Yet, despite extensive tuberculosis research over recent years, no new drugs, vaccines or diagnostics have been identified to date. It is widely speculated that the major obstacle to the identification of new therapies is the lack of understanding of the hostpathogen interaction. This study has investigated whether patterns of antigen expression correlate with molecular epidemiological data and strain virulence through the analys

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Ntolosi, Bongi Audrey. "The Mycobacterium smegmatis "Proteome" : effects of growth phase on total protein synthesis and on the response to heat shock." Doctoral thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/25661.

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As an initial step towards characterisation of the molecular processes that define the phenotype of the mycobacterial stationary phase, the effect of growth phase of Mycobacterium smegmatis on total protein synthesis and on the heat shock response was investigated. De novo protein synthesis was monitored by labelling with 35 [S]methionine and the protein expression profiles analysed using one- and/two-dimensional polyacrylamide gel electrophoresis, autoradiography, and/or immunoblot analysis. The ATP content of the culture was found to be a more accurate indicator that cells were entering stat

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Gonzalez-Rico, Susana. "The role of RNA-binding proteins in the synthesis of ribosomal RNA in Mycobacterium tuberculosis : a study of the interactions of ribosomal protein S10 and NusB with the leader region of the single rrn operon." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286690.

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Edoo, Zainab. "Mechanism of L,D-transpeptidase inhibition by β-lactams and diazabicyclooctanes". Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS565.pdf.

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La résistance aux antibiotiques est une menace mondiale qui conduit à un besoin urgent de développement de nouveaux antibiotiques. L'étude du mécanisme d'inhibition des cibles des antibiotiques est cruciale pour le développement de nouvelles molécules. Le caractère essentiel du peptidoglycane, le composant majeur de la paroi bactérienne, ainsi que soixante-dix ans d'utilisation des β-lactamines ont fait de la polymérisation du peptidoglycane une cible attractive et validée pour les antibiotiques. Les protéines de liaison à la pénicilline (PLP) ont longtemps été considérées comme les seules enz

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Saikrishnan, K. "Structural Studies On Mycobacterial Proteins." Thesis, 2005. https://etd.iisc.ac.in/handle/2005/1496.

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Saikrishnan, K. "Structural Studies On Mycobacterial Proteins." Thesis, 2005. http://etd.iisc.ernet.in/handle/2005/1496.

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Maiti, Krishnagopal. "Synthesis, Structural and Biophysical Studies of Oligosaccharide Glycolipids and Glycosidic Bond Expanded Cyclic Oligosaccharides." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3117.

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Pathogenesis originating from mycobacterial invasion on host cells is prevalent and is a major challenge in efforts towards overcoming the burden of mycobacterial diseases. Complex architecture of mycobacterium cell wall includes an assortment of glycolipids, phospholipids, glycopeptidolipids (GPLs), peptidoglycans, arabinogalactans, lipoarabinomannans and mycolic acid. Aided by thick cell wall envelope, mycobacteria are known to survive in hostile environment. As most antibiotics target the log phase of the bacteria, bacterial survival is also largely dependent on its stationary phase. Mycoba

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Book chapters on the topic "Mycobacterial Protein Synthesis"

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Kumar, Ranjeet, and Suparna Sanyal. "Mycobacterium tuberculosis: Dormancy, Persistence and Survival in the Light of Protein Synthesis." In Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli. InTech, 2012. http://dx.doi.org/10.5772/31098.

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