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Dissertations / Theses on the topic 'Mycobacterial Protein Synthesis'

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1

Zhang, Guangtao. "Design, synthesis, and evaluation of cholera toxin inhibitors and [alpha]-helix mimetics of dormancy survival regulator /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8485.

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2

Bruell, Christian M. "Mechanism of protein synthesis in Mycobacterium smegmatis /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17733.

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3

Berretta, Giacomo. "Total synthesis and semi-synthesis of lipid and protein components of Mycobacterium tuberculosis." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=15583.

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4

Pheiffer, Carmen. "Investigation of Mycobacterium tuberculosis protein expression and analysis of humoral immune responses of TB patients." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/49999.

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Thesis (PhD)--Stellenbosch University, 2004.<br>ENGLISH ABSTRACT: New agents for the diagnosis, prevention and treatment of tuberculosis are urgently required. Yet, despite extensive tuberculosis research over recent years, no new drugs, vaccines or diagnostics have been identified to date. It is widely speculated that the major obstacle to the identification of new therapies is the lack of understanding of the hostpathogen interaction. This study has investigated whether patterns of antigen expression correlate with molecular epidemiological data and strain virulence through the analys
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5

Ntolosi, Bongi Audrey. "The Mycobacterium smegmatis "Proteome" : effects of growth phase on total protein synthesis and on the response to heat shock." Doctoral thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/25661.

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As an initial step towards characterisation of the molecular processes that define the phenotype of the mycobacterial stationary phase, the effect of growth phase of Mycobacterium smegmatis on total protein synthesis and on the heat shock response was investigated. De novo protein synthesis was monitored by labelling with 35 [S]methionine and the protein expression profiles analysed using one- and/two-dimensional polyacrylamide gel electrophoresis, autoradiography, and/or immunoblot analysis. The ATP content of the culture was found to be a more accurate indicator that cells were entering stat
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6

Gonzalez-Rico, Susana. "The role of RNA-binding proteins in the synthesis of ribosomal RNA in Mycobacterium tuberculosis : a study of the interactions of ribosomal protein S10 and NusB with the leader region of the single rrn operon." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286690.

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7

Edoo, Zainab. "Mechanism of L,D-transpeptidase inhibition by β-lactams and diazabicyclooctanes". Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS565.pdf.

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La résistance aux antibiotiques est une menace mondiale qui conduit à un besoin urgent de développement de nouveaux antibiotiques. L'étude du mécanisme d'inhibition des cibles des antibiotiques est cruciale pour le développement de nouvelles molécules. Le caractère essentiel du peptidoglycane, le composant majeur de la paroi bactérienne, ainsi que soixante-dix ans d'utilisation des β-lactamines ont fait de la polymérisation du peptidoglycane une cible attractive et validée pour les antibiotiques. Les protéines de liaison à la pénicilline (PLP) ont longtemps été considérées comme les seules enz
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8

Saikrishnan, K. "Structural Studies On Mycobacterial Proteins." Thesis, 2005. https://etd.iisc.ac.in/handle/2005/1496.

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9

Saikrishnan, K. "Structural Studies On Mycobacterial Proteins." Thesis, 2005. http://etd.iisc.ernet.in/handle/2005/1496.

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10

Maiti, Krishnagopal. "Synthesis, Structural and Biophysical Studies of Oligosaccharide Glycolipids and Glycosidic Bond Expanded Cyclic Oligosaccharides." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3117.

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Pathogenesis originating from mycobacterial invasion on host cells is prevalent and is a major challenge in efforts towards overcoming the burden of mycobacterial diseases. Complex architecture of mycobacterium cell wall includes an assortment of glycolipids, phospholipids, glycopeptidolipids (GPLs), peptidoglycans, arabinogalactans, lipoarabinomannans and mycolic acid. Aided by thick cell wall envelope, mycobacteria are known to survive in hostile environment. As most antibiotics target the log phase of the bacteria, bacterial survival is also largely dependent on its stationary phase. Mycoba
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11

Maiti, Krishnagopal. "Synthesis, Structural and Biophysical Studies of Oligosaccharide Glycolipids and Glycosidic Bond Expanded Cyclic Oligosaccharides." Thesis, 2016. http://hdl.handle.net/2005/3117.

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Pathogenesis originating from mycobacterial invasion on host cells is prevalent and is a major challenge in efforts towards overcoming the burden of mycobacterial diseases. Complex architecture of mycobacterium cell wall includes an assortment of glycolipids, phospholipids, glycopeptidolipids (GPLs), peptidoglycans, arabinogalactans, lipoarabinomannans and mycolic acid. Aided by thick cell wall envelope, mycobacteria are known to survive in hostile environment. As most antibiotics target the log phase of the bacteria, bacterial survival is also largely dependent on its stationary phase. Mycoba
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12

Selvaraj, M. "Structural Studies on Mycobacterium Tuberculosis Peptidyl-tRNA Hydrolase and Ribosome Recycling Factor, Two Proteins Involved in Translation." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/2816.

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Protein synthesis is a process by which organisms manufacture their proteins that perform various cellular activities either alone or in combination with other similar or different molecules. In eubacteria, protein synthesis proceeds at a rate of around 15 amino acids per second. The ribosomes, charged tRNAs and mRNAs can be considered as the core components of protein synthesis system which, in addition, involves a panel of non-ribosomal proteins that regulate the speed, specificity and accuracy of the process. Peptidyl-tRNA hydrolase (Pth) and ribosome recycling factor (RRF) are two such
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13

Selvaraj, M. "Structural Studies on Mycobacterium Tuberculosis Peptidyl-tRNA Hydrolase and Ribosome Recycling Factor, Two Proteins Involved in Translation." Thesis, 2013. http://etd.iisc.ernet.in/handle/2005/2816.

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Abstract:
Protein synthesis is a process by which organisms manufacture their proteins that perform various cellular activities either alone or in combination with other similar or different molecules. In eubacteria, protein synthesis proceeds at a rate of around 15 amino acids per second. The ribosomes, charged tRNAs and mRNAs can be considered as the core components of protein synthesis system which, in addition, involves a panel of non-ribosomal proteins that regulate the speed, specificity and accuracy of the process. Peptidyl-tRNA hydrolase (Pth) and ribosome recycling factor (RRF) are two such
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14

Anuradha, S. "Mechanism Of Ribosome Recycling In Eubacteria, And The Impact Of rRNA Methylations On Ribosome Recycling And Fidelity Of Initiation In Esherichia coli." Thesis, 2009. https://etd.iisc.ac.in/handle/2005/629.

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The studies reported in this thesis address, firstly, aspects of ribosome recycling in eubacteria, and secondly, a preliminary characterization of an EFG-like locus from Mycobacterium smegmatis. A hitherto unsuspected role of the ribosome recycling factor in governing the fidelity of initiation has been discovered during the course of this work. A summary of the relevant literature is presented in chapter 1. Section I of the ‘General Introduction’ provides a brief review of the current understanding of protein biosynthesis, with a special emphasis on ribosome recycling and the fidelity of tran
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15

Anuradha, S. "Mechanism Of Ribosome Recycling In Eubacteria, And The Impact Of rRNA Methylations On Ribosome Recycling And Fidelity Of Initiation In Esherichia coli." Thesis, 2009. http://hdl.handle.net/2005/629.

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The studies reported in this thesis address, firstly, aspects of ribosome recycling in eubacteria, and secondly, a preliminary characterization of an EFG-like locus from Mycobacterium smegmatis. A hitherto unsuspected role of the ribosome recycling factor in governing the fidelity of initiation has been discovered during the course of this work. A summary of the relevant literature is presented in chapter 1. Section I of the ‘General Introduction’ provides a brief review of the current understanding of protein biosynthesis, with a special emphasis on ribosome recycling and the fidelity of tran
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16

Padmakar, Purnapatre Kedar. "Uracil DNA Glycosylase From Mycobacteria And Escherichia coli : Mechanism Of Uracil Excision From Synthetic Substrates And Differential Interaction With Uracil DNA Glycosylase Inhibitor (Ugi) And Single Stranded DNA Binding Proteins (SSBs)." Thesis, 1999. https://etd.iisc.ac.in/handle/2005/1567.

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17

Padmakar, Purnapatre Kedar. "Uracil DNA Glycosylase From Mycobacteria And Escherichia coli : Mechanism Of Uracil Excision From Synthetic Substrates And Differential Interaction With Uracil DNA Glycosylase Inhibitor (Ugi) And Single Stranded DNA Binding Proteins (SSBs)." Thesis, 1999. http://etd.iisc.ernet.in/handle/2005/1567.

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