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Journal articles on the topic 'Mycobacterium bovis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Dib, Cristina Corsi. "Main challenges in molecular diagnosis of tuberculosis of bovine origin." Brazilian Journal of Animal and Environmental Research 8, no. 1 (2025): e77206. https://doi.org/10.34188/bjaerv8n1-058.

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Bovine tuberculosis is a chronic infectious disease that affects animals and humans and is caused by Mycobacterium bovis. The human disease caused by Mycobacterium bovis is called zoonotic disease and is clinically and pathologically indistinguishable from the disease caused by Mycobacterium tuberculosis. Therefore, the differentiation of mycobacterial species responsible for pulmonary tuberculosis is extremely important, since Mycobacterium bovis is resistant to pyrazinamide, a drug commonly used to treat infection with Mycobacterium tuberculosis. The bacteriological diagnosis of bovine tuber

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Jiang, Qiang, Rong Hu, Feng Liu, Feng Huang, Lei Zhang, and Hua Zhang. "Characterization of a Novel Oxidative Stress Responsive Transcription Regulator in Mycobacterium bovis." Biomedicines 12, no. 8 (2024): 1872. http://dx.doi.org/10.3390/biomedicines12081872.

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The antioxidant defense is critical for the survival of intracellular pathogens such as Mycobacterium tuberculosis complex (MTBC) species, including Mycobacterium bovis, which are often exposed to an oxidative environment caused by reactive oxygen species (ROS) in hosts. However, the signaling pathway in mycobacteria for sensing and responding to oxidative stress remains largely unclear. In this study, we characterize a TetR-type transcription regulator BCG_3893c, designated AotM, as a novel redox sensor in Mycobacterium bovis that increases mycobacterial tolerance to oxidative stress. AotM is

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Szacawa, Ewelina, Nina Kozieł, Sylwia Brzezińska, et al. "Laboratory Diagnosis of Animal Tuberculosis in Tracing Interspecies Transmission of Mycobacterium bovis." Pathogens 14, no. 5 (2025): 459. https://doi.org/10.3390/pathogens14050459.

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Mycobacterium is one of the most dangerous pathogens of both animals and humans. Bovine tuberculosis (BTB) is a disease caused by mycobacteria belonging to the Mycobacterium tuberculosis complex (MTBC), which spreads mainly among domestic cattle but also to mammals other than cattle. The transmission of MTBC between different species requires research and epidemiological investigations to control its spread. When multiple species are a reservoir of infection, it poses a significant public health and veterinary concern. In this study, the diagnosis of alpaca, cattle, horses, dogs, a sheep and a

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KRYSZTOPA-GRZYBOWSKA, KATARZYNA, SYLWIA BRZEZIŃSKA, EWA AUGUSTYNOWICZ-KOPEĆ, EWA AUGUSTYNOWICZ, and ANNA LUTYŃSKA. "PCR-Based Genomic Deletion Analysis of RD-Regions in the Identification of Mycobacteria Isolated from Adverse Events Following BCG Vaccination or TB Suspected Cases." Polish Journal of Microbiology 63, no. 3 (2014): 359–62. http://dx.doi.org/10.33073/pjm-2014-048.

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Early identification of mycobacterial species is crucial for early diagnosis. PCR-multiplex method performed on randomly chosen 54 mycobacteria isolates originating from clinical samples was found to be an inexpensive, quick and reliable alternative for commercially available diagnostics tests. Although the results of gene probes identification performed by NTLDR were generally consistent with multiplex PCR, two mixed Mycobacterium bovis BCG/Mycobacterium tuberculosis infections and a single misdiagnosis of M. tuberculosis with M. bovis were found. The routine application of multiplex-PCR has

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Waters, W. R., B. J. Nonnecke, M. V. Palmer, et al. "Use of Recombinant ESAT-6:CFP-10 Fusion Protein for Differentiation of Infections of Cattle by Mycobacterium bovis and by M. avium subsp. avium and M. avium subsp. paratuberculosis." Clinical Diagnostic Laboratory Immunology 11, no. 4 (2004): 729–35. http://dx.doi.org/10.1128/cdli.11.4.729-735.2004.

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ABSTRACT Immunological diagnosis of Mycobacterium bovis infection of cattle is often confounded by cross-reactive responses resulting from exposure to other mycobacterial species, especially Mycobacterium avium. Early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) are dominant gamma interferon (IFN-γ)-inducing antigens of tuberculous mycobacteria, and they are absent from many environmental nontuberculous mycobacteria. Because M. avium exposure is the primary confounding factor in the diagnosis of M. bovis-infected animals, in vitro responses to a recombinant ES

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Waters, W. R., A. O. Whelan, K. P. Lyashchenko, et al. "Immune Responses in Cattle Inoculated with Mycobacterium bovis, Mycobacterium tuberculosis, or Mycobacterium kansasii." Clinical and Vaccine Immunology 17, no. 2 (2009): 247–52. http://dx.doi.org/10.1128/cvi.00442-09.

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ABSTRACT Cattle were inoculated with Mycobacterium bovis, Mycobacterium tuberculosis, or Mycobacterium kansasii to compare the antigen-specific immune responses to various patterns of mycobacterial disease. Disease expression ranged from colonization with associated pathology (M. bovis infection) and colonization without pathology (M. tuberculosis infection) to no colonization or pathology (M. kansasii infection). Delayed-type hypersensitivity and gamma interferon responses were elicited by each mycobacterial inoculation; however, the responses by the M. bovis- and M. tuberculosis-inoculated a

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Stern, Rebecca, Clay Roscoe, and Elizabeth A. Misch. "<i>Mycobacterium bovis</i> BCG osteoarticular infection complicating immune therapy for bladder cancer: a case report." Journal of Bone and Joint Infection 6, no. 4 (2021): 107–10. http://dx.doi.org/10.5194/jbji-6-107-2021.

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Abstract. Osteoarticular infection with Mycobacterium bovis (M. bovis) is a rare complication of bladder cancer treatment with intravesical Bacillus Calmette–Guèrin (BCG). We describe a case of disseminated Mycobacterium bovis BCG infection masquerading as a chronic prosthetic joint infection in a patient with several risk factors for progressive mycobacterial infection.

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Aldwell, Frank E., Bridget L. Dicker, Fernanda M. Da Silva Tatley, et al. "Mycobacterium bovis-Infected Cervine Alveolar Macrophages Secrete Lymphoreactive Lipid Antigens." Infection and Immunity 68, no. 12 (2000): 7003–9. http://dx.doi.org/10.1128/iai.68.12.7003-7009.2000.

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ABSTRACT Tuberculosis is caused by intracellular bacteria belonging to the genus Mycobacterium, including M. tuberculosisand M. bovis. Alveolar macrophages (AMs) are the primary host cell for inhaled mycobacteria. However, little is known about the mechanisms by which infected AMs can process and present mycobacterial antigens to primed lymphocytes and how these responses may affect ensuing protection in the host. In the present study, we sought to determine whether AMs from a naturally susceptible host forMycobacterium bovis (red deer) could produce and secrete soluble immunoreactive antigens

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Ekladious, Adel. "Disseminated Mycobacterium Bovis." International Journal of Clinical Case Reports and Reviews 11, no. 4 (2022): 01–03. http://dx.doi.org/10.31579/2690-4861/232.

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Intravesical BacillusChalmette- Guerin (BCG) still a popular medication for non-invasive bladdercancer in the low-income country, one of the uncommon side effects is disseminated Mycobacterium Bovis. We present a patient who presented with haematuria, diagnosed as urothelial superficial bladder cancer, treated with incomplete resectionand intravesical BCG, 6 months after treatment, he presented with increasing shortness of breath, headache and abdominal pain, diagnosed as tuberculous, meningitis, massive pleural effusion, granulomatous hepatitis he responded very well to anti tuberculous treat

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Da Silva Pedroso, Silvia Cristina, Karla Valéria Batista Lima, Ismari Perini Furlaneto, et al. "Bovine tuberculosis due to Mycobacterium bovis and other mycobacteria among water buffalo (Bubalus bubalis) from the Brazilian Amazon." Journal of Infection in Developing Countries 15, no. 05 (2021): 736–41. http://dx.doi.org/10.3855/jidc.13558.

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Introduction: Zoonotic tuberculosis is a disease of public health importance worldwide, especially in developing countries. The present study aimed to investigate the role played by Mycobacterium bovis and other mycobacteria as etiologic agents of bubaline tuberculosis (TB) in the Brazilian Amazon region. Methodology: Granulomatous lesions suggestive of TB obtained from 109 buffaloes (n =109) during sanitary inspection at slaughter were subjected to histopathological evaluation, immunohistochemical (IHC) detection of Mycobacterium antigens, and to molecular tests (PCR) to detect hsp65, I

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Erb, Klaus J., Claudia Trujillo, Mike Fugate, and Heidrun Moll. "Infection with the Helminth Nippostrongylus brasiliensis Does Not Interfere with Efficient Elimination of Mycobacterium bovis BCG from the Lungs of Mice." Clinical and Vaccine Immunology 9, no. 3 (2002): 727–30. http://dx.doi.org/10.1128/cdli.9.3.727-730.2002.

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ABSTRACT Infection with Mycobacterium tuberculosis continues to be one of the major global health threats. Strong mycobacterium-specific Th1 immune responses correlate with protection, and decreased Th1 responses correlate with disease progression. In contrast, the impact of Th2 responses on the development of protective immune responses to mycobacteria remains unclear. To analyze whether ongoing Th2 responses present in the lung influence the development of a protective Th1 immune response to mycobacteria, we coinfected mice with the helminth Nippostrongylus brasiliensis and Mycobacterium bov

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Gobin, Jovana, Diane K. Wong, Bradford W. Gibson, and Marcus A. Horwitz. "Characterization of Exochelins of theMycobacterium bovis Type Strain and BCG Substrains." Infection and Immunity 67, no. 4 (1999): 2035–39. http://dx.doi.org/10.1128/iai.67.4.2035-2039.1999.

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ABSTRACT Pathogenic mycobacteria must acquire iron in the host in order to multiply and cause disease. To do so, they release abundant quantities of siderophores called exochelins, which have the capacity to scavenge iron from host iron-binding proteins and deliver it to the mycobacteria. In this study, we have characterized the exochelins of Mycobacterium bovis, the causative agent of bovine and occasionally of human tuberculosis, and the highly attenuated descendant of M. bovis, bacillus Calmette-Guérin (BCG), widely used as a vaccine against human tuberculosis. The M. bovis type strain, fi

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DIDKOWSKA, ANNA, PIOTR ŻMUDA, BLANKA ORŁOWSKA, and KRZYSZTOF ANUSZ. "Mycobacterial infections in cats (Felis catus) as a potential threat to humans – a review 2014–2023." Medycyna Weterynaryjna 79, no. 12 (2023): 6842–2023. http://dx.doi.org/10.21521/mw.6842.

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Mycobacteria infections in cats include tuberculosis (caused by Mycobacterium bovis and Mycobacterium microti) and mycobacteriosis caused by non-tuberculous mycobacteria (NTM). The aim of the paper is to present the latest reports on mycobacterial infections in cats and place emphasis on their impact on the health of their owners. The reviewers looked for papers about mycobacterial infections in cats in PubMed and Google Scholar from any date from January 2014 to June 2023. The search used the following keywords: cat, feline, tuberculosis, and mycobacteria. Papers were evaluated for their valu

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Savova-Lalkovska, Tanya, Violeta Valcheva, Albena Dimitrova, Hristo Najdenski, and Magdalena Bonovska. "Advantages of Real-time PCR and RD4-PCR as Molecular Methods for Rapid Detection of Bovine Tuberculosis in Bulgaria." Proceedings of the Bulgarian Academy of Sciences 75, no. 11 (2022): 1696–704. http://dx.doi.org/10.7546/crabs.2022.11.18.

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Representatives of Mycobacterium tuberculosis complex (MTBC) are potential causative agents of tuberculosis in animals and humans, and Mycobacterium bovis is considered a major one among domestic and wild ruminants. In the last twenty years, the role of another representative of MTBC – Mycobacterium caprae, has been proven in the countries of Central and Southern Europe. Study sample included 121 diagnostic materials from lymph nodes and lungs from cattle, positively and doubtfully PPD tuberculin-reacted, originating from 6 farms belonging to the 4 regions in Northern and Southern Bulgaria. Th

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Guerra-Maupome, Mariana, Michelle H. Larsen, Mitchell V. Palmer, Ray Waters та Jodi L. McGill. "Characterization of bovine γδ T cells phenotype during post-natal development and following Mycobacterium bovis vaccination or virulent infection". Journal of Immunology 198, № 1_Supplement (2017): 131.17. http://dx.doi.org/10.4049/jimmunol.198.supp.131.17.

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Abstract Bovine tuberculosis caused by Mycobacterium bovis is a globally significant veterinary health problem. γδ T cells participate in the immune control of mycobacterial infections. Data in human and non-human primates suggest that mycobacterial infection regulates memory/effector phenotype and adaptive immune functions of mycobacterium-responsive γδ T cells. To date, the impact of age or M. bovis infection on bovine γδ T cells memory/effector phenotype remains unknown. In this study, we addressed the age-dependent changes of circulating γδ T cells, analyzed functional and phenotypic diffe

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Bhakta, Sanjib, Gurdyal S. Besra, Anna M. Upton, et al. "Arylamine N-Acetyltransferase Is Required for Synthesis of Mycolic Acids and Complex Lipids in Mycobacterium bovis BCG and Represents a Novel Drug Target." Journal of Experimental Medicine 199, no. 9 (2004): 1191–99. http://dx.doi.org/10.1084/jem.20031956.

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Mycolic acids represent a major component of the unique cell wall of mycobacteria. Mycolic acid biosynthesis is inhibited by isoniazid, a key frontline antitubercular drug that is inactivated by mycobacterial and human arylamine N-acetyltransferase (NAT). We show that an in-frame deletion of Mycobacterium bovis BCG nat results in delayed entry into log phase, altered morphology, altered cell wall lipid composition, and increased intracellular killing by macrophages. In particular, deletion of nat perturbs biosynthesis of mycolic acids and their derivatives and increases susceptibility of M. bo

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Fritz, Christian, Silvia Maass, Andreas Kreft, and Franz-Christoph Bange. "Dependence of Mycobacterium bovis BCG on Anaerobic Nitrate Reductase for Persistence Is Tissue Specific." Infection and Immunity 70, no. 1 (2002): 286–91. http://dx.doi.org/10.1128/iai.70.1.286-291.2002.

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ABSTRACT Mycobacterium bovis BCG, the only presently available vaccine against tuberculosis, was obtained from virulent M. bovis after serial passages in vitro. The vaccine strain retained at least some of its original virulence, as it persists in immune-competent hosts and occasionally may cause fatal disease in immune-deficient hosts. Mycobacterial persistence in vivo is thought to depend on anaerobic metabolism, an apparent paradox since all mycobacteria are obligate aerobes. Here we report that M. bovis BCG lacking anaerobic nitrate reductase (NarGHJI), an enzyme essential for nitrate resp

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Mailaender, Claudia, Norbert Reiling, Harald Engelhardt, Stefan Bossmann, Stefan Ehlers, and Michael Niederweis. "The MspA porin promotes growth and increases antibiotic susceptibility of both Mycobacterium bovis BCG and Mycobacterium tuberculosis." Microbiology 150, no. 4 (2004): 853–64. http://dx.doi.org/10.1099/mic.0.26902-0.

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Porins mediate the diffusion of hydrophilic solutes across the outer membrane of mycobacteria, but the efficiency of this pathway is very low compared to Gram-negative bacteria. To examine the importance of porins in slow-growing mycobacteria, the major porin MspA of Mycobacterium smegmatis was expressed in Mycobacterium tuberculosis and Mycobacterium bovis. Approximately 20 and 35 MspA molecules per μm2 cell wall were observed in M. tuberculosis and M. bovis BCG, respectively, by electron microscopy and quantitative immunoblot experiments. Surface accessibility of MspA in M. tuberculosis was

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Jordao, L., M. Simoes, C. Bleck, G. Griffiths, and E. Anes. "Characterization of Mycobacterium bovis Phagosome." Microscopy and Microanalysis 14, S3 (2008): 124–25. http://dx.doi.org/10.1017/s1431927608089629.

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Mycobacterium tuberculosis complex are among the most successful pathogens. Their success resides in the ability to interfere with intracellular traffic avoiding natural pathways of the phagosome maturation. Recently, mycobacteria escape from the phagosome to the cytosol was investigated as an alternative survival strategy. In this context we decided to determine the exact intracellular location of Mycobacterium bovis in different host macrophages and characterize the pathogen intracellular niche for survival. The main goal here was to characterize live vs dead M. bovis spp phagosome in differ

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Wang, Chun Fang, Hua Rui Qi, Xiu Yun Jiang, Hong Xia Ma, Ai Dong Qian, and Chun Feng Wang. "Isolated Strains of Nontuberculous Mycobacterium Interfere with Immune Responses Associated with Mycobacterium Bovis BCG Vaccination." Advanced Materials Research 884-885 (January 2014): 450–54. http://dx.doi.org/10.4028/www.scientific.net/amr.884-885.450.

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Prior exposure of a vaccine to certain species of environmental mycobacteria can prime the immune system against common mycobacterial antigens, which can in turn reduce the subsequent efficacy of live attenuated mycobacterial vaccines (such as Mycobacterium bovis BCG), in both human and livestock vaccination programs. In this study, five strains of nontubeculous mycobacterium, all isolated from lymphonodi mandibulares and lymphonodi mesenterici samples of swine and cattle, were investigated to determine their growth characteristics and effects on the immune system in murine models. Markedly, d

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Skinner, Margot A., D. Neil Wedlock, Geoffrey W. de Lisle, et al. "The Order of Prime-Boost Vaccination of Neonatal Calves with Mycobacterium bovis BCG and a DNA Vaccine Encoding Mycobacterial Proteins Hsp65, Hsp70, and Apa Is Not Critical for Enhancing Protection against Bovine Tuberculosis." Infection and Immunity 73, no. 7 (2005): 4441–44. http://dx.doi.org/10.1128/iai.73.7.4441-4444.2005.

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ABSTRACT Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp70, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that

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Ghodbane, Ramzi, Felix Mba Medie, Hubert Lepidi, Claude Nappez, and Michel Drancourt. "Long-term survival of tuberculosis complex mycobacteria in soil." Microbiology 160, no. 3 (2014): 496–501. http://dx.doi.org/10.1099/mic.0.073379-0.

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While there is evidence for the persistence of Mycobacterium bovis in soil, there are no reports for the other Mycobacterium tuberculosis complex (MTC) mycobacteria. Here, soil was inoculated with 108 c.f.u. g−1 M. tuberculosis, M. bovis and M. canettii and subcultured monthly for 12 months. The pathogenicity of mycobacterial colonies, identified by using matrix-assisted laser desorption/ionization time of flight mass spectrometry, was assessed in a mouse model. Moreover, mice were fed with food that contained 16.7 % M. tuberculosis-contaminated soil. The three tested MTC species survived in s

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Thoen, Charles O., William J. Quinn, Lyle D. Miller, Larry L. Stackhouse, Bradford F. Newcomb, and James M. Ferrell. "Mycobacterium Bovis Infection in North American Elk (Cervus Elaphus)." Journal of Veterinary Diagnostic Investigation 4, no. 4 (1992): 423–27. http://dx.doi.org/10.1177/104063879200400410.

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A naturally occurring outbreak of Mycobacterium bovid infection in captive wild elk (wapiti) in Montana was confirmed by mycobacteriologic examination. Twenty-eight of 143 elk responded to M. bovis purified protein derivative (PPD) tuberculin injected intradermally in the cervical region (SCT). The results of comparative cervical tuberculin skin tests conducted within 9 days of SCT revealed greater responses to M. bovis PPD tuberculin than to M. avium PPD tuberculin in 23 of 28 elk responding. At necropsy, several grossly visible tuberculous lesions were observed in the parenchyma of the lung,

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Krajewska, Monika, Michał Załuski, Anna Zabost, et al. "Tuberculosis in Antelopes in a Zoo in Poland – Problem of Public Health." Polish Journal of Microbiology 64, no. 4 (2015): 395–97. http://dx.doi.org/10.5604/17331331.1185242.

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Bovine tuberculosis is an infectious disease that occurs in many species of both domestic and wild animals, as well as those held in captivity. The etiological factor is the acid resistant bacillus (Mycobacterium bovis or Mycobacterium caprae), which is characterized by the major pathogenicity among mycobacteria belonging to the Mycobacterium tuberculosis complex. The material from 8 antelopes from the zoo, suspected for tuberculosis were examined, and M. bovis strains were isolated from 6 of them. The spoligotyping method showing spoligo pattern 676763777777600. In Poland, this spoligotype ha

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Lee, Jinhee, Keumhwa Choi, Michael R. Olin, Sang-Nae Cho та Thomas W. Molitor. "γδ T Cells in Immunity Induced by Mycobacterium bovis Bacillus Calmette-Guérin Vaccination". Infection and Immunity 72, № 3 (2004): 1504–11. http://dx.doi.org/10.1128/iai.72.3.1504-1511.2004.

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ABSTRACT Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination is efficacious for newborns or adults with no previous exposure to environmental mycobacteria. To determine the relative contribution and the nature of γδ T-cell receptor-positive T cells in newborns, compared to CD4+ T cells, in immunity induced by M. bovis BCG vaccination, 4-week-old specific-pathogen-free pigs were vaccinated with M. bovis BCG and monitored by following the γδ T-cell immune responses. A flow cytometry-based proliferation assay and intracellular staining for gamma interferon (IFN-γ) were used to examine

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Baratov, M. O. "Towards improved differential diagnostics of bovine tuberculosis in the Republic of Dagestan." Veterinary Science Today 14, no. 2 (2025): 164–70. https://doi.org/10.29326/2304-196x-2025-14-2-164-170.

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Introduction. Non-specific tuberculin reactions are among the most critical challenges in tuberculosis diagnosis, with their incidence increasing annually. Given the complex epidemiological challenges, improving bovine tuberculosis diagnostics is critically important.Objective. Development of effective comprehensive differential bovine tuberculosis diagnosis and introduction of improved techniques for the infection detection in farms with different animal health statuses in the Republic of Dagestan.Materials and methods. 1,670 cattle were subjected to tuberculin testing; 3,502 serum samples we

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Nau, Gerard J., Lucy Liaw, Geoffrey L. Chupp, Jeffrey S. Berman, Brigid L. M. Hogan, and Richard A. Young. "Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin." Infection and Immunity 67, no. 8 (1999): 4223–30. http://dx.doi.org/10.1128/iai.67.8.4223-4230.1999.

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ABSTRACT Expression of the cytokine osteopontin (OPN) is elevated in granulomas caused by Mycobacterium tuberculosis. We tested the hypothesis that OPN contributes to host protection in a mouse model of mycobacterial infection. When infected with Mycobacterium bovis BCG, mice lacking a functional OPN gene had more severe infections characterized by heavier bacterial loads and a delayed clearance of the bacteria. The OPN-null mice had greater granuloma burdens consistent with the elevated bacterial load. The ability of osteopontin to facilitate the clearance of mycobacteria was most pronounced

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Platonova, Ya B., V. A. Kirillova, A. N. Volov, and S. V. Savilov. "Synthesis and antituberculosis activity of new 5-alkynyl derivatives of 2-thiouridine: application of new scaffold." Журнал органической химии 59, no. 12 (2023): 1598–607. http://dx.doi.org/10.31857/s0514749223120042.

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We herein describe new potent inhibitors of mycobacteria based on 5-substituted 2-thiouridine derivatives. A series of new 5-alkynyl-substituted 2-thiouridine derivatives were synthesized via palladium-catalysed Sonogashira cross-coupling reaction of 5-iodo-2-thiopyrimidine base with terminal acetylenes with good yields in DMF at room temperature. It was found that sulfur atom in C2 position of pyrimidine ring had no impact on yields of target compounds. All obtained compounds were evaluated for their antimycobacterial activity against Mycobacetrium bovis and Mycobacterium tuberculosis at conc

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Guallar-Garrido, Sandra, Víctor Campo-Pérez, Alejandro Sánchez-Chardi, Marina Luquin, and Esther Julián. "Each Mycobacterium Requires a Specific Culture Medium Composition for Triggering an Optimized Immunomodulatory and Antitumoral Effect." Microorganisms 8, no. 5 (2020): 734. http://dx.doi.org/10.3390/microorganisms8050734.

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Mycobacterium bovis bacillus Calmette-Guérin (BCG) remains the first treatment option for non-muscle-invasive bladder cancer (BC) patients. In research laboratories, M. bovis BCG is mainly grown in commercially available media supplemented with animal-derived agents that favor its growth, while biomass production for patient treatment is performed in Sauton medium which lacks animal-derived components. However, there is not a standardized formulation of Sauton medium, which could affect mycobacterial characteristics. Here, the impact of culture composition on the immunomodulatory and antitumor

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Moriconi, Patricia Rossi, Cássia Yumi Ikuta, Fábio Gregori, et al. "Mycobacteria in Minas cheese commercialized in open fairs in São Paulo, Brazil." Brazilian Journal of Veterinary Research and Animal Science 55, no. 4 (2018): e146525. http://dx.doi.org/10.11606/issn.1678-4456.bjvras.2018.146525.

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Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that affects dairy herds throughout the Brazilian territory, constituting a neglected zoonosis transmitted by raw milk and its derivatives. In this study, we evaluated the presence of M. bovis and other mycobacteria in Minas cheese obtained from open fairs in the city of São Paulo between 2012 and 2013. Samples (n = 133) were decontaminated using hexa-cetylpyridinium chloride and seeded on Stonebrink–Leslie medium. The isolates were submitted to molecular identification by TB Multiplex PCR targeting the 16S rRNA gene

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Fulton, Scott A., Scott M. Reba, Rish K. Pai, et al. "Inhibition of Major Histocompatibility Complex II Expression and Antigen Processing in Murine Alveolar Macrophages by Mycobacterium bovis BCG and the 19-Kilodalton Mycobacterial Lipoprotein." Infection and Immunity 72, no. 4 (2004): 2101–10. http://dx.doi.org/10.1128/iai.72.4.2101-2110.2004.

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ABSTRACT Alveolar macrophages constitute a primary defense against Mycobacterium tuberculosis, but they are unable to control M. tuberculosis without acquired T-cell immunity. This study determined the antigen-presenting cell function of murine alveolar macrophages and the ability of the model mycobacterium, Mycobacterium bovis BCG, to modulate it. The majority (80 to 85%) of alveolar macrophages expressed both CD80 (B7.1) and CD11c, and 20 to 30% coexpressed major histocompatibility complex II (MHC-II). Gamma interferon (IFN-γ) enhanced MHC-II but not B7.1 expression. Naive or IFN-γ-treated a

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Jarnagin, J. L., and G. S. Colgrove. "Identification of Mycobacterium bovis, using miniaturized thin-layer chromatography and morphologic characteristics." American Journal of Veterinary Research 47, no. 11 (1986): 2346–48. https://doi.org/10.2460/ajvr.1986.47.11.2346.

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SUMMARY Lipid analysis was performed on 204 isolates of mycobacteria, using miniaturized thin-layer chromatography (mtlc). A previously described lipid component was found in 92 (96.8%) of 95 isolates of Mycobacterium bovis and in 2 (1.8%) of 109 isolates of other mycobacteria. Using mtlc, an isolate could be identified as M bovis 3 to 4 weeks earlier than by use of conventional biochemical techniques. Examination of isolates for colonial and cellular morphologic characteristics was a useful adjunct in the identification of M bovis by use of mtlc.

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Uygur Külcü, Nihan, Feray Güven, Burçin Nalbantoğlu, et al. "Mycobacterium Bovis Meningitis: Case Report." Journal of Pediatric Infection 6, no. 2 (2012): 59–63. http://dx.doi.org/10.5152/ced.2012.14.

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Norton, Robert E., Richard Lumb, and David R. Shaw. "Mycobacterium bovis meningitis." Medical Journal of Australia 162, no. 5 (1995): 276–77. http://dx.doi.org/10.5694/j.1326-5377.1995.tb139890.x.

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Nandavaram, Sravanthi, Abdullah Al Twal, Helen Jacoby, and Robert Lenox. "Mycobacterium bovis Aneurysm." Infectious Diseases in Clinical Practice 24, no. 6 (2016): e69-e70. http://dx.doi.org/10.1097/ipc.0000000000000438.

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Unsworth, J. D., and A. Bonington. "Mycobacterium bovis tenosynovitis." Case Reports 2013, jun13 1 (2013): bcr2013009257. http://dx.doi.org/10.1136/bcr-2013-009257.

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Panesar, Jaswinder, Kevin Higgins, Vito Forte, and Upton Allen. "Revisiting Mycobacterium bovis." Journal of Otolaryngology 31, no. 01 (2002): 58. http://dx.doi.org/10.2310/7070.2002.19248.

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Holdiness, M. R. "Mycobacterium bovis infection." Archives of Internal Medicine 145, no. 10 (1985): 1930b—1930. http://dx.doi.org/10.1001/archinte.145.10.1930b.

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Holdiness, Mack R. "Mycobacterium bovis Infection." Archives of Internal Medicine 145, no. 10 (1985): 1930. http://dx.doi.org/10.1001/archinte.1985.00360100204047.

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Nicolle, Delphine, Cécile Fremond, Xavier Pichon, et al. "Long-Term Control of Mycobacterium bovis BCG Infection in the Absence of Toll-Like Receptors (TLRs): Investigation of TLR2-, TLR6-, or TLR2-TLR4-Deficient Mice." Infection and Immunity 72, no. 12 (2004): 6994–7004. http://dx.doi.org/10.1128/iai.72.12.6994-7004.2004.

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ABSTRACT Live mycobacteria have been reported to signal through both Toll-like receptor 2 (TLR2) and TLR4 in vitro. Here, we investigated the role of TLR2 in the long-term control of the infection by the attenuated Mycobacterium, Mycobacterium bovis BCG, in vivo. We sought to determine whether the reported initial defect of bacterial control (K. A. Heldwein et al., J. Leukoc. Biol. 74:277-286, 2003) resolved in the chronic phase of BCG infection. Here we show that TLR2-deficient mice survived a 6-month infection period with M. bovis BCG and were able to control bacterial growth. Granuloma form

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Rochard, Vincent, Thierry Cochard, Stéphanie Crapart, et al. "Presence of Non-Tuberculous Mycobacteria Including Mycobacterium avium subsp. paratuberculosis Associated with Environmental Amoebae." Animals 13, no. 11 (2023): 1781. http://dx.doi.org/10.3390/ani13111781.

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One of the obstacles to eradicating paratuberculosis or Johne’s Disease (JD) seems to be the persistence of Mycobacterium avium subsp. paratuberculosis (Map) in the environment due to its ability to survive alone or vectorized. It has been shown that Map is widely distributed in soils and water. Previously, we isolated amoebae associated with Map strains in the environment of bovines from an infected herd. This work aims to verify our working hypothesis, which suggests that amoebae may play a role in the transmission of JD. In this study, we sampled water in the vicinity of herds infected with

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Fine, Amanda E., Daniel J. O'Brien, Scott R. Winterstein, and John B. Kaneene. "An Effort to Isolate Mycobacterium bovis from Environmental Substrates during Investigations of Bovine Tuberculosis Transmission Sites (Cattle Farms and Wildlife Areas) in Michigan, USA." ISRN Veterinary Science 2011 (September 22, 2011): 1–11. http://dx.doi.org/10.5402/2011/787181.

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Deer movements on cattle farms, wildlife feeding, and livestock management practices in Michigan are thought to create opportunities for indirect transmission of Mycobacterium bovis via environmental substrates. To confirm the presence of viable M. bovis in the environment, substrates were collected from 13 farms with culture-confirmed M. bovis in cattle and 5 sites with high prevalence of M. bovis in free-ranging deer. None of the samples processed for mycobacterial culture were positive for M. bovis. Agent, host, and landscape-level factors decrease the probability of detecting M. bovis in t

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Chilima, Benson Z., Ian M. Clark, Sian Floyd, Paul E. M. Fine, and Penny R. Hirsch. "Distribution of Environmental Mycobacteria in Karonga District, Northern Malawi." Applied and Environmental Microbiology 72, no. 4 (2006): 2343–50. http://dx.doi.org/10.1128/aem.72.4.2343-2350.2006.

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ABSTRACT The genus Mycobacterium includes many species that are commonly found in the environment (in soil and water or associated with plants and animals), as well as species that are responsible for two major human diseases, tuberculosis (Mycobacterium tuberculosis) and leprosy (Mycobacterium leprae). The distribution of environmental mycobacteria was investigated in the context of a long-term study of leprosy, tuberculosis, Mycobacterium bovis BCG vaccination, and the responses of individuals to various mycobacterial antigens in Karonga District, northern Malawi, where epidemiological studi

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Beatty, Wandy L., and David G. Russell. "Identification of Mycobacterial Surface Proteins Released into Subcellular Compartments of Infected Macrophages." Infection and Immunity 68, no. 12 (2000): 6997–7002. http://dx.doi.org/10.1128/iai.68.12.6997-7002.2000.

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ABSTRACT Considerable effort has focused on the identification of proteins secreted from Mycobacterium spp. that contribute to the development of protective immunity. Little is known, however, about the release of mycobacterial proteins from the bacterial phagosome and the potential role of these molecules in chronically infected macrophages. In the present study, the release of mycobacterial surface proteins from the bacterial phagosome into subcellular compartments of infected macrophages was analyzed. Mycobacterium bovis BCG was surface labeled with fluorescein-tagged succinimidyl ester, an

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Li, Xiaohui, Liu Chen, Jingjing Liao, Jiechen Hui, Weihui Li, and Zheng-Guo He. "A novel stress-inducible CmtR-ESX3-Zn2+ regulatory pathway essential for survival of Mycobacterium bovis under oxidative stress." Journal of Biological Chemistry 295, no. 50 (2020): 17083–99. http://dx.doi.org/10.1074/jbc.ra120.013017.

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Reactive oxygen species (ROS) are an unavoidable host environmental cue for intracellular pathogens such as Mycobacterium tuberculosis and Mycobacterium bovis; however, the signaling pathway in mycobacteria for sensing and responding to environmental stress remains largely unclear. Here, we characterize a novel CmtR-Zur-ESX3-Zn2+ regulatory pathway in M. bovis that aids mycobacterial survival under oxidative stress. We demonstrate that CmtR functions as a novel redox sensor and that its expression can be significantly induced under H2O2 stress. CmtR can physically interact with the negative re

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Arain, T. M., A. E. Resconi, D. C. Singh, and C. K. Stover. "Reporter gene technology to assess activity of antimycobacterial agents in macrophages." Antimicrobial Agents and Chemotherapy 40, no. 6 (1996): 1542–44. http://dx.doi.org/10.1128/aac.40.6.1542.

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Reporter strains of Mycobacterium tuberculosis and Mycobacterium bovis BCG endogenously expressing firefly luciferase were used in bioluminescence assays to evaluate the activities of isoniazid and rifampin against mycobacteria sequestered in human macrophages. This methodology allowed the efficacy of antibiotics against intracellular mycobacteria to be assessed without the labor-intensive procedures and protracted incubation requirements associated with conventional CFU determinations.

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Fujita, Yukiko, Takashi Naka, Michael R. McNeil, and Ikuya Yano. "Intact molecular characterization of cord factor (trehalose 6,6′-dimycolate) from nine species of mycobacteria by MALDI-TOF mass spectrometry." Microbiology 151, no. 10 (2005): 3403–16. http://dx.doi.org/10.1099/mic.0.28158-0.

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Cord factor (trehalose 6,6′-dimycolate, TDM) is an unique glycolipid with a trehalose and two molecules of mycolic acids in the mycobacterial cell envelope. Since TDM consists of two molecules of very long branched-chain 3-hydroxy fatty acids, the molecular mass ranges widely and in a complex manner. To characterize the molecular structure of TDM precisely and simply, an attempt was made to determine the mycolic acid subclasses of TDM and the molecular species composition of intact TDM by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry for the first tim

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Bach-Griera, Marc, Alba Hernández, and Esther Julián. "Mycobacteria Treatment Inhibits Bladder Cancer Cell Migration, Invasion, and Anchorage-Independent Growth." International Journal of Molecular Sciences 25, no. 23 (2024): 12997. https://doi.org/10.3390/ijms252312997.

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Bladder cancer (BC) is a highly recurrent and invasive malignancy, with Mycobacterium bovis BCG serving as the primary immunotherapy, particularly for non-muscle-invasive bladder cancer (NMIBC). However, the mechanisms underlying BCG’s antitumor effects and the potential of non-tuberculous mycobacteria like Mycobacterium brumae remain unclear. This study investigates the antitumor effects of M. bovis BCG and M. brumae on BC cell migration, invasion, and anchorage-independent growth. BC cell lines representing different stages of tumor differentiation were treated with either M. bovis BCG or M.

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Silva, Pedro E. A., Fabiana Bigi, Marı́a de la Paz Santangelo, et al. "Characterization of P55, a Multidrug Efflux Pump inMycobacterium bovis and Mycobacterium tuberculosis." Antimicrobial Agents and Chemotherapy 45, no. 3 (2001): 800–804. http://dx.doi.org/10.1128/aac.45.3.800-804.2001.

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ABSTRACT The Mycobacterium bovis P55 gene, located downstream from the gene that encodes the immunogenic lipoprotein P27, has been characterized. The gene was identical to the open reading frame of the Rv1410c gene in the genome of Mycobacterium tuberculosisH37Rv, annotated as a probable drug efflux protein. Genes similar toP55 were present in all species of the M. tuberculosis complex and other mycobacteria such asMycobacterium leprae and Mycobacterium avium. By Western blotting, P55 was located in the membrane fraction ofM. bovis. When transformed into Mycobacterium smegmatis after cloning,

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Marassi, Carla D., Flávia C. S. de Oliveira, Sonia R. Pinheiro, et al. "Evaluation of a MPB70-ELISA to differentiate Mycobacterium bovis from M. avium-sensitized swine." Pesquisa Veterinária Brasileira 34, no. 11 (2014): 1069–72. http://dx.doi.org/10.1590/s0100-736x2014001100005.

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Swine are susceptible to different mycobacteria species, being Mycobacterium bovis an agent of tuberculosis, with most significant zoonotic risks, while M. avium determines a granulomatous lymphadenitis with low zoonotic risk. Currently performed intradermal tests present some important limitations, such as the lack of ability to detect anergic animals or to differentiate among mycobacterial species. In order to improve the TB diagnosis, serological assays have been developed, with encouraging results. The purpose of this study was to evaluate the performance of a MPB70-ELISA in 82 piglets div

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