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Dissertations / Theses on the topic 'Mycobacterium DNA Binding Protein'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Alvarez, Martinez Jesus Antonio. "Role of [gamma][delta]-T cells in mycobacterial infection and inflammation /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcitt?p9999268.

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2

Bisset, Louise Clair. "Fluorescence of a DNA-binding protein." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320129.

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3

Slayton, Mark D. "Protein-DNA Interactions of pUL34, an Essential Human Cytomegalovirus DNA-Binding Protein." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1533638730703166.

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4

Fekete, Richard Alfred. "Characterizing the protein and DNA interactions of the F plasmid DNA binding protein, TraM." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60291.pdf.

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5

Goddard, C. "DNA and chromatin binding by the methyl-CpG-binding protein, MeCP2." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599452.

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In eukaryotes, methylation at CpG dinucleotides causes transcriptional repression. MeCP2 is a good candidate for a transducer of this methylation signal as it is capable of binding to methylated DNA and can repress transcription <i>in vitro</i>. This thesis describes experiments to further investigate the DNA and chromatin binding properties of MeCP2. Chapter 2 describes the subcloning, overexpression and purification of recombinant rat MeCP2 and also the purification of native MeCP2 from rat brain. The similarity in purification protocols indicates that the recombinant protein is a good model

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6

Andrade, Helena. "DNA Oligomers - From Protein Binding to Probabilistic Modelling." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-218709.

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This dissertation focuses on rationalised DNA design as a tool for the discovery and development of new therapeutic entities, as well as understanding the biological function of DNA beyond the storage of genetic information. The study is comprised of two main areas of study: (i) the use of DNA as a coding unit to illustrate the relationship between code-diversity and dynamics of self-assembly; and (ii) the use of DNA as an active unit that interacts and regulates a target protein. In the study of DNA as a coding unit in code-diversity and dynamics of self-assembly, we developed the DNA-Based

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7

Maynard, Allister J. "NMR studies of protein folding and DNA binding." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313244.

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8

Povey, Jane. "Structural studies of the DNA-binding protein GAL4." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385462.

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9

Cruickshank, Jennifer. "The DNA binding mechanism of the Epstein-Barr origin binding protein, EBNA1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0006/MQ46091.pdf.

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10

Phillips, Christine M. (Christine Marie). "Relating metal binding to DNA binding in the nickel regulatory protein NikR." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57569.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Vita. Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>The concentration of transition metals within the cell must be tightly regulated. If the concentration of a given transition metal is too low the cell may not be able to perform life-sustaining processes, while high levels of metals are poisonous to the cell a

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11

Roberts, Jennifer Nicole. "Investigating the DNA binding properties of the Telomere End-Binding Protein Cdc13." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3337145.

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12

Hlatshwayo, Nkosikhona Rejoyce. "Comparison of protein binding microarray derived and ChIP-seq derived transcription factor binding DNA motifs." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1017907.

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Transcription factors (TFs) are biologically important proteins that interact with transcription machinery and bind DNA regulatory sequences to regulate gene expression by modulating the synthesis of the messenger RNA. The regulatory sequences comprise of short conserved regions of a specific length called motifs . TFs have very diverse roles in different cells and play a very significant role in development. TFs have been associated with carcinogenesis in various tissue types, as well as developmental and hormone response disorders. They may be responsible for the regulation of oncogenes and

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13

Preston, Nicola Susan. "Structure and DNA binding of HMG boxes." Thesis, University of Portsmouth, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310386.

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14

Nilsson, Mikael. "Protein-DNA recognition : in vitro evolution and characterization of DNA-binding proteins /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4269.

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15

James, Daniel Peter. "Computational methods for the measurement of protein-DNA interactions." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277257.

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It is of interest to know where in the genome DNA binding proteins act in order to effect their gene regulatory function. For many sequence specific DNA binding proteins we plan to predict the location of their action by having a model of their affinity to short DNA sequences. Existing and new models of protein sequence specificty are investigated and their ability to predict genomic locations is evaluated. Public data from a micro-fluidic experiment is used to fit a matrix model of binding specificity for a single transcription factor. Physical association and disassociation constants from th

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16

Qureshi, Aaron M. "A combinatorial design of a protein-binding DNA microarray." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/2081.

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Thesis (M.S.) -- University of Maryland, College Park, 2004.<br>Thesis research directed by: Dept. of Mathematics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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17

Howard, Victoria Jayne. "Transcription activation and DNA binding by the MelR protein." Thesis, University of Birmingham, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288933.

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18

Martin, Andrew. "Glycosylated green fluorescent protein for carbohydrate binding protein analysis." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/glycosylated-green-fluorescent-protein-for-carbohydrate-binding-protein-analysis(9ddae46e-b4d7-4c08-8240-94b9b804ac68).html.

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The interactions of glycoconjugates with carbohydrate binding proteins are responsible for a wide range of recognition events in vivo; including immune response, cell adhesion and signal transduction. Glycoconjugates have already found many medicinal uses as therapeutic and diagnostic agents, but their full potential is yet to be realised. Access to a variety of homogeneously glycosylated glycoproteins is essential for the study of these important carbohydrate binding events. This requires the chemical synthesis and attachment of biologically relevant glycans to unglycosylated protein scaffold

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19

Anderson, Lisa Louise. "A Study of Penicillin Binding Proteins in Mycobacterium Tuberculosis." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin991667301.

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20

Aldridge, Matthew J. "Functional analysis of a novel DNA binding protein of Streptomyces coelicolor." Thesis, Swansea University, 2012. https://cronfa.swan.ac.uk/Record/cronfa42406.

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Secondary metabolism occurs after the main growth phase in Streptomyces. A 'transition phase' occurs to remodel global patterns of gene expression at the onset of physiological and developmental differentiation. Many different signals influence this transition phase, integrating, for example, information on nutritional status, growth rate, and stress responses. Several pleiotropic transcription factors that regulate the transition phase have been identified, but aspects of epigenetic control of gene expression are not well understood. This study focused on the characterisation of a novel gene

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21

Bess, Kirstin. "Transcriptional repression by the proline rich homeodomain protein." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390994.

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22

Moore, Tim. "The RdgC protein of Escherichia coli." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250574.

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23

Byun, Jung Shin. "Characterization of TATA box binding protein interaction with minicircle DNA." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/3060.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2005.<br>Thesis research directed by: Biochemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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24

Massad, Tariq. "Structural Studies of Flexible Biomolecules and a DNA-binding Protein." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-42009.

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The knowledge of the three-dimensional structures of proteins and polypeptides is essential to understand their functions. The work shown in this thesis has two objectives. The first one is to develop a new analytical method based on maximum entropy (ME) theory to analyze NMR experimental data such as NOEs and J-couplings in order to reconstitute φ,ψ Ramachandran plots of flexible biomolecules. Two model systems have been used, the flexible polypeptide motilin and the disaccharide α-D-Mannosep-(1-2)-α-D-Mannosep-O-Me (M2M). The experimental data was defined as constraints that were combined wi

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25

Dixon, Christopher Hugh. "The DNA binding activity of the potato NBLRR protein Rx1." Thesis, Durham University, 2017. http://etheses.dur.ac.uk/12257/.

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Plant NBLRR proteins are immune receptors named for their characteristic domains. Their mode of action is currently undetermined. The potato NBLRR protein Rx1 has been shown to possess a DNA binding activity in vitro. This thesis presents evidence that Rx1 binds DNA in response to its cognate elicitor CP106 in fixed N. benthamiana leaf material using a novel FRET-FLIM assay. The Rx1 CC and NBARC domains were both shown to possess this DNA binding activity. A nucleocytoplasmic distribution of Rx1 was shown to be required for DNA binding. Potential regulators of Rx1 DNA binding activity were ide

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26

Zhong, Yichen. "Mechanistic Studies of Human Chromodomain-Helicase-DNA-Binding Protein 4." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23473.

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In eukaryotic cells, genomic DNA is organized into small units called nucleosomes, each of which generally consists of a histone octamer and DNA wrapping around this histone core, so that the whole genome can be efficiently packed into a small nucleus. On the other hand, the presence of nucleosome remodelers ensures the genetic information still remains accessible to regulatory factors. Although it was known for a long time that these remodellers can weaken the interaction between the DNA and histones in an ATP-dependent manner to expose part of the DNA sequence, the underlying mechanisms have

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27

Tam, Brooke Elizabeth. "DNA methylation detection using an engineered methyl-CpG-binding protein." Thesis, Massachusetts Institute of Technology, 2018. https://hdl.handle.net/1721.1/121898.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2018<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 96-103).<br>DNA methylation, specifically the methylation of cytosine bases, is an important biomarker, as abnormal DNA methylation patterns are found in many different types of cancer. Currently, a small number of cancer hospitals evaluate the methylation status of the MGMT gene promoter to determine the best course of treatment for patients with glioblastoma. However, improved methylation detection techniques ar

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28

Leonard, Philip Martin. "Structural studies on the LrpA protein from Pyrococcus furiosus." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247186.

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29

Luo, Dan. "Novel cross-linking technologies to assess protein-DNA binding and DNA-DNA complexes for gene delivery and expression /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487946776022443.

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30

Amato, Nicholas J. "Impact of DNA Structure and Aeropyrum pernix Single-Strand DNA Binding Protein on Oxidative Damage to DNA." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1372296254.

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31

Luo, Dan. "Novel crosslinking technologies to assess protein-DNA binding and DNA-DNA complexes for gene delivery and expression." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1114436532.

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32

Luo, Dan. "Novel crosslinking technologies to assess protein-DNA binding and DNA-DNA complexes for gene delivery and expression /." Connect to resource, 1998. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1114436532.

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33

Jenkins, Huw Thomas. "Human C4b-binding protein, structural basis for interaction with streptococcal M protein and DNA." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/12289.

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Human C4b-binding protein (C4BP) protects host tissue, and those pathogens able to hijack this plasma glycoprotein, from complement-mediated destruction. For example, C4BP localises to apoptotic and necrotic cells, via its affinity for DNA, whereupon this regulator helps to prevent complement activation and subsequent inflammation and tissue damage. The first two CCP modules of the C4BP alpha-chain, plus the four residues connecting them, are necessary and sufficient for binding a bacterial virulence factor, the <i>Streptococcus pyogenes</i> M4 (Arp4) protein. Structure determination of this r

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34

Bolotin, Eugene Leonidovich. "Investigation of transcription factor binding sequences and target genes using protein binding microarrays." Diss., [Riverside, Calif.] : University of California, Riverside, 2010. http://proquest.umi.com/pqdweb?index=0&did=2019822801&SrchMode=2&sid=3&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1274203752&clientId=48051.

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Thesis (Ph. D.)--University of California, Riverside, 2010.<br>Includes abstract. Available via ProQuest Digital Dissertations. Title from first page of PDF file (viewed May 18, 2010). Includes bibliographical references. Also issued in print.

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35

Guelev, Vladimir Metodiev. "Peptide-based polyintercalators as sequence-specific DNA binding agents /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008346.

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36

Reini, K. (Kaarina). "Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)". Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514282787.

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Abstract Genetic information is stored in the base sequence of DNA. As DNA is often damaged by radiation or reactive chemicals, cells have developed mechanisms to correct the DNA lesions. These mechanisms involve recognition of damage, DNA repair and cell cycle delay until DNA is restored. Failures in the proper processing of DNA lesions may lead to mutations, premature aging, or diseases such as cancer. In this thesis study the human topoisomerase IIβ binding protein 1 (TopBP1) was identified as the homolog of budding yeast Dpb11 and fission yeast Cut5. TopBP1 was found to be necessary for D

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37

Chamalaun-Hussey, Nicole D. "Characterisation of DNA-binding by the creA protein of Aspergillus nidulans." Title page, abstract and contents only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phc442.pdf.

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Errata pasted onto front end-paper. Bibliography: p. 261-288. Focuses on the mechanism of action of the creA gene product of A. nidulans, and its ability to control the regulated expression of three genes for which there exists evidence for control by creA at the transcription level.

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38

Wu, Qiaohua. "Biochemical characterization of the major DNA-binding protein of murine cytomegalovirus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0019/NQ37924.pdf.

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39

Kiesel, Anja Sophie [Verfasser], and Johannes [Akademischer Betreuer] Söding. "Understanding protein-DNA binding events / Anja Sophie Kiesel ; Betreuer: Johannes Söding." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1148276823/34.

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40

Howland, Christopher James. "The single-stranded DNA-binding protein gene of plasmid Colib-P9." Thesis, University of Leicester, 1989. http://hdl.handle.net/2381/34428.

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The Incil plasmid Colib-P9 was found to carry a single-stranded DNA-binding protein gene (ssb), and the cloned gene was able to suppress the UV and temperature-sensitivity of an ssb-l strain of Escherichia coli K-12. Determination of the nucleotide sequence of Colib ssb demonstrated that the gene shows considerable homology to the ssb gene of plasmid F. In contrast, Southern hybridization techniques indicated that the IncP plasmid RP4 lacks a gene with any extensive homology to F ssb. It was shown that the direction of transfer of Colib-P9 is such that the Colib ssb gene, which lies approximat

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41

Murakami, Shinya. "Biochemical characterization of CND41,a nucleoid DNA binding protein in chloroplast." Kyoto University, 2000. http://hdl.handle.net/2433/78113.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第8529号<br>農博第1138号<br>新制||農||807(附属図書館)<br>学位論文||H12||N3432(農学部図書室)<br>UT51-2000-J38<br>京都大学大学院農学研究科農芸化学専攻<br>(主査)教授佐藤文彦, 教授關谷次郎, 教授大山莞爾<br>学位規則第4条第1項該当

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42

FOTINS, JURIS. "CREATION AND INVESTIGATION OF PROTEIN CORE MIMETICS AND DNA BINDING MOLECULES." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1122494693.

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43

Han, Ji Hoon. "Fluorescent Nucleobases for Studying DNA Structure, Protein Interaction and Metal Binding." Kyoto University, 2019. http://hdl.handle.net/2433/242637.

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44

Johnson, Cotteka Nichisha. "Characterization of the DNA-binding properties of silent information regulator 3 protein." Huntington, WV : [Marshall University Libraries], 2006. http://www.marshall.edu/etd/descript.asp?ref=691.

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45

Zhang, Yuexuan. "A new regulator of initiation of DNA replication : Noc3p /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?BICH%202002%20ZHANG.

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46

Vargas, Jesse. "Protein-DNA interactions : characterization of a definitive DNA binding sequence consensus for full length mammalian DEAF-1 and determination of the DNA binding potential of the tumor metastasis related protein, MTA1 /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1483331711&sid=2&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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47

Lee, Joseph. "Investigating the protein-protein interactions between TAR DNA-binding protein 43 AND p65 subunit of NF-κB". Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57029.

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TAR DNA-binding Protein 43 (TDP-43), a ubiquitous protein that regulates gene expression, has been found to play a crucial role in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS), in which the disease is characterized by TDP-43 protein inclusion bodies. Relevant literature suggests that the protein either self-aggregates or interacts with various partners to cause this proteinopathy. One of these binding partners was suggested to be the p65 domain of the nuclear factor kappa-B (NF-κB), a transcription protein complex which plays a crucial role in inflammatory and immune responses. It i

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48

Moore, Joel M. "Investigating the DNA binding properties of the initiator binding protein 2 (IBP2) in maize (Zea mays)." Tallahassee, Florida : Florida State University, 2009. http://etd.lib.fsu.edu/theses/available/etd-11092009-115855/.

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Thesis (M.A.)--Florida State University, 2009.<br>Advisor: Hank W. Bass, Florida State University, College of Arts and Sciences, Dept. of Biological Science. Title and description from dissertation home page (viewed on May 3, 2010). Document formatted into pages; contains vi, 23 pages. Includes bibliographical references.

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49

Taniguchi, Yoshihito. "LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein." Kyoto University, 1998. http://hdl.handle.net/2433/182239.

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50

Williams, Sunanda Margrett. "The Dynamics of Iron in Miniferritins : A Structure-Function Connection." Thesis, 2014. http://etd.iisc.ernet.in/handle/2005/2788.

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The DNA binding proteins under starvation (Dps) from M. smegmatis are cage-like structures which internalize iron and bind DNA. They provide resistance to the cells from free radical damage, and physically protect the DNA from the harmful effects of reactive oxygen species by DNA compaction. The work compiled in this thesis has been an effort to study oligomerization and dynamics of iron metabolism by these nano-protein compartments. Chapter 1 gives a general introduction on stress, especially oxidative stress, and the ways bacteria fight back the host resistance systems. This has been elabora

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