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Dissertations / Theses on the topic 'Mycobacterium Tuberculi'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Kurtz, Tatiana. "Avalia??o do efeito da vacina??o BCG na rea??o do Teste Tubercul?nico (TT) nos dois primeiros anos de vida." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2017. http://tede2.pucrs.br/tede2/handle/tede/7855.

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GIOVANNINI, DANIELA. "Identification of putative small non coding RNAs in mycobacterium tuberculosis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/208815.

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Mycobacterium tuberculosis è l‘agente eziologico che causa la tubercolosi nell‘uomo. Recentemente la regolazione post-trascrizonale mediata dagli sRNA è stata dimostrata in un ampio gruppo di batteri patogeni, nei quali è implicata nel controllo della virulenza. Attraverso una analisi bioinformatica abbiamo individuato nelle regioni intergeniche del genoma di M. tuberculosis 3 nuovi sRNAs, identificati come sRNAs 1B, sRNAs 5e sRNAs 12B. Eseguendo una ricerca nella banca dati BLAST abbiamo verificato la presenza di questi tre sRNA nel genoma di tutti i ceppi batterici appartenenti al gruppo de

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3

Franca, Adriana Pinheiro da. "Estudo microbiológico e histopatológico da glândula mamária de caprinos tuberculina positivo." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-06012012-105707/.

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Até recentemente acreditava-se que a tuberculose em caprinos fosse uma enfermidade rara, o que levou ao errôneo conceito de que esses animais fossem resistentes ao Mycobacterium bovis. Este trabalho tem por objetivo verificar se houve processo inflamatório da glândula mamária devido a agentes de mastite ou à presença de Mycobacterium, comparar a frequência de isolamento pelo teste de Zielh-Neelsen nas amostras de leite e dos fragmentos de glândula mamária de caprinos tuberculina positivo e verificar lesões encontradas na glândula mamária com frequência semelhante aos isolados pelo teste de Zie

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4

Bonnet, Isabelle. "Rôle de whiB6 et kdpDE dans le clone MDR hypertransmissible B0/W148 de Mycobacterium tuberculosi." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS478.pdf.

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La tuberculose (TB) est, hors COVID, la première cause de décès lié à un agent infectieux. La détermination rapide du profil de résistance complet de Mycobacterium tuberculosis (Mtb) est essentielle pour démarrer un traitement adapté dans les cas de TB multirésistante (MDR) et ainsi limiter l’acquisition de résistances supplémentaires, augmenter les chances de succès thérapeutique et réduire la transmission de ces souches. Il existe 9 lignées principales au sein du complexe M. tuberculosis, dont 2 sont largement répandues dans le monde (L2 et L4). Au sein de la lignée 2, le clone W148 (ou comp

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5

Bombonato, Nadia Grandi. "Tuberculinização e aspectos epidemiológicos da tuberculose caprina na mesorregião do Triângulo Mineiro e Alto Paranaíba." Universidade Federal de Uberlândia, 2009. https://repositorio.ufu.br/handle/123456789/12954.

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Data on caprine tuberculosis in Brazil and its importance for public health are scarce. Therefore, the purpose of this study was to investigate the occurrence and examine epidemiological aspects of tuberculosis in dairy goat herds in the Triângulo Mineiro and Alto Paranaíba mesoregion in the state of Minas Gerais, Brazil. Two hundred and thirty-three goats from seven dairy farms were tuberculinized using the comparative cervical tuberculin test, taking as reference the procedures and interpretation criteria of standard results for this species. Of the animals subjected to the test, 1.29% (3/23

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6

Blankenheim, Thalita Masoti. "Resposta à tuberculinização em bovinos sensibilizados com inóculos inativados de Mycobacterium avium e de Mycobacterium bovis /." Jaboticabal, 2016. http://hdl.handle.net/11449/141991.

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Orientador: Luis Antonio Mathias<br>Banca: Anna Monteiro Correia Lima<br>Banca: Adolorata Aparecida Bianco Carvalho<br>Banca: Raphaella Barbosa Meirelles Bartoli<br>Banca: Samir Issa Samara<br>Resumo: A tuberculose causada pelo Mycobacterium bovis é uma importante doença dos bovinos e constitui um grande problema de saúde animal, podendo também atingir humanos. Para o diagnóstico da infecção, e para desencadear as medidas sanitárias decorrentes desse diagnóstico, o Programa Nacional de Controle e Erradicação de Brucelose e Tuberculose (PNCEBT) estabelece a utilização de testes intradérmicos de

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7

PIGOLI, CLAUDIO. "MYCOBACTERIAL DISEASES IN VETERINARY MEDICINE: MORPHOPATHOLOGY AND MYCOBACTERIAL PHENOTYPES." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/843675.

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Mycobacteria are an ancient bacterial taxon that has, over time, had a profound impact on mankind and domesticated animals. Mycobacteria are, in fact, responsible for significant human and animal diseases whose severe economic and public health repercussions make them still highly topical today. The first topic of research in this Thesis is a widely characterized phenomenon in the context of human tuberculosis, but one which has, to date, been little considered in animal tubercular infections, namely mycobacterial dormancy. As bovine tuberculosis (bTB) is undoubtedly the most significant of

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8

Singh, U. "Approach towards identification of anti-tubercular lead molecules by targeting mycobacterium tuberculosis glutamine synthetase." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2010. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3748.

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9

Villar, Hernández Raquel. "Towards a better diagnosis of mycobacterial infections. IGRAs and beyond." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669407.

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El género Mycobacterium incluye más de 200 especies, la mayoría presentes en el medio ambiente. Mycobacterium tuberculosis, perteneciente al complejo M. tuberculosis, es el agente etiológico de tuberculosis (TB) en humanos. TB es la primera causa mundial de muerte por un único agente infeccioso estimándose que 23% de la población mundial está infectada. Identificar estos casos es clave para controlar la TB. Sin embargo, el diagnóstico de infección tuberculosa latente (ITBL) tiene limitaciones y las pruebas existentes no diferencian ITBL de TB, las distintas fases del espectro de TB, ni indican

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10

Abuhammad, Areej. "Arylamine N-Acetyltransferases from mycobacteria : investigations of a potential target for anti-tubercular therapy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:3f571661-7b51-4fa8-bf5e-2adff9269c59.

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Reactivation of latent infection is the major cause of tuberculosis (TB). Cholesterol is a critical carbon source during latent infection. Catabolism of cholesterol contributes to the pool of propionyl-CoA, a precursor that is incorporated into cell-wall lipids. Arylamine N-acetyltransferase (NAT) is encoded within a gene cluster that is involved in the sterol-ring degradation and is essential for intracellular survival. NAT from M. tuberculosis (TBNAT) can utilise propionyl-CoA and therefore was proposed as a target for TB-drug development. Deleting the nat gene or inhibiting the NAT enzyme p

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11

SILVA, NETO Francisco Bernardino da. "Teste tuberculínio no diagnóstico da infecção latente pelo Mycobacterium tuberculosis em pessoas vivendo com HIV/AIDS em um hospital de referência no Estado da Paraíba." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/17702.

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Borsuk, Sibele. "Construção de marcador auxotrófico em Mycobacterium bovis BCG, de uma cepa knockout para DPPD e estudo proteômico da tuberculina." Universidade Federal de Pelotas, 2008. http://repositorio.ufpel.edu.br/handle/ri/1257.

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Made available in DSpace on 2014-08-20T13:32:52Z (GMT). No. of bitstreams: 1 tese_sibele_borsuk.pdf: 16306468 bytes, checksum: 4743a54f442368d81ff802d8290c7cfc (MD5) Previous issue date: 2008-02-28<br>Mycobacterium bovis BCG has the potential to be an effective live vector for multivalent vaccines. However, there are two problems regarding the utilization of recombinant BCG as vaccine. The first one is that most mycobacterial cloning vectors rely on antibiotic resistance gene as selectable marker, which is used for genetic transformation. The second one is the limited use of BCG in an

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13

VOLPE, ELISABETTA. "Gene expression profiling of mycobacterium tuberculosis and human macrophage during host-pathogen interaction." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2004. http://hdl.handle.net/2108/208538.

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I macrofagi giocano un ruolo essenziale nella risposta immune a Mycobacterium tuberculosis (Mtb), ma Mtb ha evoluto una serie di meccanismi per superare le risposte macrofagiche e può sopravvivere a lungo all’interno del macrofago umano. Lo studio della risposta trascrizionale all’infezione sia dell’ospite che del patogeno, potrebbe essere interessante per conoscere meglio questa interazione. Con questo scopo noi abbiamo analizzato, a livello trascrizionale, la relazione tra virulento Mtb e macrofago umano dopo 7 giorni di infezione, usando la tecnica del macroarray. Noi abbiamo settato una

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14

SANTUCCI, MARILINA BENEDETTA. "Ruolo della sfingosina 1-fosfato nella risposta immunitaria all’ infezione da mycobacterium tuberculosis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2004. http://hdl.handle.net/2108/208530.

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In questa tesi è stato studiato il ruolo della sfingosina 1-fosfato (S1P) nella risposta immunitaria durante l’infezione da M. tuberculosis. La S1P è un lipide bioattivo che regola diverse funzioni biologiche cellulari. In questo contesto, è stata analizzata l’attività anti-micobatterica in cellule della linea monocito/macrofagica, THP-1 ed in una linea tumorale di cellule dell’epitelio alveolare, A549 infettate con il ceppo patogeno di M. tuberculosis H37Rv e stimolate con S1P. La crescita di M. tuberculosis è stata valutata tramite il saggio delle unità formanti colonia ed i risultati di que

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15

Morrone, Castrese. "Biochemical and structural characterization of proteins involved in prokaryotic DNA metabolism as source of novel drug targets and biotechnological solutions." Doctoral thesis, Università del Piemonte Orientale, 2021. http://hdl.handle.net/11579/127798.

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The aim of the presented PhD project was the biochemical and structural characterization of proteins and enzymes involved in prokaryotic DNA metabolism as potential target for antitubercular drug discovery as well as for the design of biotechnological tools for application in molecular biology. A variant of the 06-DNA-alkyl-guanine-DNA-alkyl-transferases (OGT) from Saccharolobus solfataricus (HS) has been proposed as a thermostable self-labelling protein tag in order to expand this technology to harsh experimental conditions and extreme environments. We present here the crystal structure of H5

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16

Aboubaker, Osman Djaltou. "Epidémiologie des mycobactéries en Polynésie française." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5033/document.

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La tuberculose est due à un groupe d’agents infectieux phylogénétiquement proches formant le complexe Mycobacterium tuberculosis, formé de dix espèces. M. tuberculosis est un bacille à croissance lente qui forme des colonies rugueuses. Le complexe M. tuberculosis comporte également des bacilles tuberculeux formant des colonies lisses à croissance rapide, isolées qu’à partir de prélèvements cliniques chez l’homme. Notre revue des articles sur ces souches a montré que les trois premiers isolats ont été obtenus chez des patients en France, à Madagascar et en Polynésie Française par Georges Canett

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17

Tudó, i. Vilanova Griselda. "Estudi de la transmissió de la tuberculosi en el context nosocomial i poblacional: caracterització fenotípica i genotípica de soques de Mycobacterium tuberculosis." Doctoral thesis, Universitat de Barcelona, 2004. http://hdl.handle.net/10803/673164.

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Anualmente se producen 9 millones de casos de tuberculosis. La fuente de transmisión principal de la enfermedad son los bacilos que expulsan los enfermos al expectorar, inhalados por otras personas. El objetivo general de la tesis es el estudio de la transmisión de la tuberculosis en el contexto nosocomial y poblacional. En cuanto a los objetivos concretos, son los siguientes: 1,- Análisis de la transmisión nosocomial de la tuberculosis en pacientes ingresados en un hospital de tercer nivel durante un periodo de 4 años, utilizando la técnica de tipado molecular RFLP. 2,- Descripción

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18

Bierrenbach, Ana Luiza De Souza. "Immune responses to BCG at school age : influence of neonatal BCG and positive skin test responses to tuberculin and non-tuberculous mycobacteria sensitins." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408168.

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19

CHAVASCO, Juliana Moscardini. "Avaliação da atividade antimicrobiana de extratos vegetais de plantas encontradas no cerrados do sul de minas gerais." Universidade Federal de Alfenas, 2013. https://bdtd.unifal-mg.edu.br:8443/handle/tede/271.

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O uso indiscriminado de antimicrobianos pode estar associado ao fenômeno da resistência microbiana, levando ao insucesso no tratamento das infecções e impulsionando a busca por novas alternativas terapêuticas, dentre elas, os bioativos obtidos a partir de fontes vegetais. Foi avaliada a atividade antimicrobiana de extratos hidroetanólicos de plantas sobre bactérias Gram positiva, Gram negativa, leveduras, Mycobacterium tuberculosis H37 e Mycobacterium bovis pela técnica de difusão em agar e microdiluição em caldo. Dentre os extratos avaliados pelo método de difusão em agar, o extrato de Biden

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20

FIORIO, SILVIA. "ANALISI DI UNA NUOVA METODICA DI LABORATORIO PER LO STUDIO DELLA RISPOSTA IMMUNOLOGICA ALL’INFEZIONE LATENTE DA MYCOBACTERIUM TUBERCULOSIS." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3426530.

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Identification and treatment of individuals with latent tuberculosis infection (LTBI) is an important component of tuberculosis elimination strategies in low incidence countries. In this context, health care workers (HCWs) represent an important target population for LTBI screening programmes and serial testing is recommended for HCWs. Interferon–gamma release assays (IGRAs) are alternatives to the tuberculin skin test (TST) and have been recommended for serial testing, but data are scarce on the interpretation of repeated IGRAs results. Existing studies, although limited, suggest that convers

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21

Moure, González Raquel. "Detección rápida de Mycobacterium tuberculosis complex y de la resistencia a los fármacos antituberculosos mediante métodos de amplificación genética e hibridación." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/145469.

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El diagnóstico de la tuberculosis (TB) se basa en gran medida en métodos microbiológicos convencionales: a) un cribado mediante microscopía de bacilos ácido-alcohol resistentes que permite de forma rápida, sencilla y económica una primera orientación hacia el diagnóstico de TB en caso de que la baciloscopia sea positiva; y b) el cultivo de las muestras clínicas en medios específicos para micobacterias. El cultivo micobacteriano es el método considerado gold standard en el diagnóstico microbiológico de la TB, y además, permite obtener el aislamiento clínico con el que posteriormente se puede es

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22

Herzer, ThaÃs LÃbo. "InfecÃÃo latente por mycobacterium tuberculosis em portadores de infecÃÃo por HIV/AIDS: anÃlise atravÃs do uso de teste tuberculÃnico e teste de liberaÃÃo de interferon-gama." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7821.

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As pessoas vivendo com HIV tÃm probabilidade aumentada de desenvolver, apresentar formar graves, ter cepas multirresistentes e morrer por tuberculose. A profilaxia para infecÃÃo latente por Mycobacteium tuberculosis (ILTB) diminui a chance de ativaÃÃo de tuberculose (TB) numa mÃdia de 62% nessa populaÃÃo. Entretanto, o diagnÃstico da TB na sua forma latente Ã controverso. O teste tuberculÃnico (TT) Ã o Ãnico exame aprovado no Brasil para avaliaÃÃo dessa infecÃÃo, embora existam problemas tanto na sua realizaÃÃo quanto na sua interpretaÃÃo. Exames de liberaÃÃo de interferon-gama foram criados r

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23

Bouzid, Feriel. "La Canettose, une maladie infectieuse émergente dans la corne de l'Afrique." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0548/document.

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La tuberculose est l’une des maladies infectieuses mortelles les plus fréquentes, causée par des mycobactéries tuberculeuses dont principalement M. tuberculosis. Notre thèse a porté sur Mycobacterium canettii caractérisée par un morphotype lisse et un temps de génération plus court que M. tuberculosis. Notre revue de la littérature a montré que moins d'une centaine de cas d’infection à M. canettii ont été rapportés majoritairement à Djibouti située dans la Corne de l’Afrique. Ensuite, notre étude prospective de la tuberculose pulmonaire à Djibouti a mesuré une prévalence d’infections à M. cane

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Muñoz, López Laura. "Improving diagnostic strategies for latent tuberculosis infection in populations at risk for developing active disease." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/461911.

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BACKGROUND Latent tuberculosis infection (LTBI) management is a crucial component of tuberculosis prevention in high-risk individuals. A global approach including diagnosis and treatment completion ensures good outcomes.T-cell-based interferon-gamma release assays (IGRAs) were first developed a decade ago, at which time they represented a promising alternative to the tuberculin skin test (TST); however, they too are limited by their poor ability to predict future active TB, being only slightly better than TST at best. Since the implementation of IGRAs, several cross-sectional studies showed t

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Garziera, Giovana. "Prevalência de teste tuberculínico positivo prévio ao uso de imunobiológicos em pacientes reumatológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/158291.

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Base teórica: A introdução de agentes biológicos, especialmente os bloqueadores do fator de necrose tumoral (anti-TNF), para o tratamento de doenças reumáticas aumentou o risco de desenvolver tuberculose (TB). O rastreio para infecção tuberculosa latente (ILTB) é fortemente recomendado antes de iniciar a terapia com agentes anti-TNF. Os objetivos deste estudo foram identificar a prevalência de ILTB e TB entre pacientes com doenças reumáticas em uso dos medicamentos anti-TNF. Métodos: Estudo transversal. Foram revisados os registros médicos eletrónicos de todos os doentes adultos (≥ 18 anos) em

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26

Marszalek, Marta Anna. "The DosRST two-component system of Mycobacterium tuberculosis: Characterizing the activation mechanism of DosR response regulator as a potential target for novel antimycobacterial drugs." Doctoral thesis, Universitat Ramon Llull, 2014. http://hdl.handle.net/10803/275939.

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La tuberculosi, la malaltia infecciosa causada per Mycobacterium tuberculosis, es un problema de salut global que provoca aproximadament 2 milions de morts anuals. Un terç de la població mundial es troba crònicament infectada amb Mycobacterium tuberculosis però no mostra símptomes clínics encara que té un risc d’un 10% de desenvolupar la malaltia, la qual cosa representa un reservori incontrolable de tuberculosi. En aquesta condició asimptomàtica, coneguda com a tuberculosi latent, Mycobacterium tuberculosis es localitza en lesions granulomatoses a l’hoste i és resistent als medicaments antim

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Rey, Jurado Emma. "Virulence of drug-resistant Mycobacterium tuberculosis and activity of drug combinations against drug-resistant and drug-susceptible isolates in ex-vivo and in vitro models." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/107758.

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Tuberculosis (TB) remains a global threat worldwide with nearly nine million incident cases of TB. The emergence of M. tuberculosis resistance to antituberculous drugs has led to the need for careful TB surveillance and control. Further knowledge of drug-resistant M. tuberculosis plays an important role in avoiding TB transmission as well as designing more efficient schedules of treatment. The objectives were: 1) to analyse of clinical isolates of Mycobacterium tuberculosis resistant to antituberculous drugs to penetrate and grow within murine macrophages compared with drug-susceptible iso

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FIORIO, SILVIA. "ANALISI DI UNA NUOVA METODICA DI LABORATORIO PER LO STUDIO DELLA RISPOSTA IMMUNOLOGICA ALL'INFEZIONE LATENTE DA MYCOBACTERIUM TUBERCULOSIS." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3426531.

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Identification and treatment of individuals with latent tuberculosis infection (LTBI) is an important component of tuberculosis elimination strategies in low incidence countries. In this context, health care workers (HCWs) represent an important target population for LTBI screening programmes and serial testing is recommended for HCWs. Interferon-gamma release assays (IGRAs) are alternatives to the tuberculin skin test (TST) and have been recommended for serial testing, but data are scarce on the interpretation of repeated IGRAs results. Existing studies, although limited, suggest that convers

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Silvestri, Davide. "Nuove strategie per la rilevazione ad alta sensibilità di analiti biologici." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423798.

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The activities of this PhD, done in the context of the PLATFORM strategic project of the University of Padua, dealt with the study and optimization of analytical techniques for the detection of biologically relevant analytes of different kinds, as proteins, nucleic acids, small molecules. The research relied essentially on two technological platforms currently under development in the laboratories of reference, and was carried in tight collaboration with other research groups of the University of Padua. The first platform exploited the surface plasmon resonance (SPR) for the detection of the

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Gaschignard, Jean. "Génétique humaine des formes cliniques de la lèpre." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB133/document.

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La lèpre est une maladie tropicale négligée qui atteint près de 200 000 personnes chaque année et dont l’agent causal est Mycobacterium leprae. La susceptibilité génétique de l’hôte à la maladie est bien établie, et a permis de comprendre certains mécanismes de la physiopathologie de la maladie. Il existe par ailleurs une grande variabilité inter-individuelle des manifestions cliniquesde la maladie, qui s’étendent d’un pôle dit tuberculoïde à un pôle dit lépromateux. Nous avons cherché à identifier les facteurs de susceptibilité génétique à cette polarisation de la maladie. Nous avons tout d’a

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Awah, Ndukum Julius. "Epidemiology and public health significance of bovine tuberculosis in cattle in the highlands of Cameroon." Thesis, University of Plymouth, 2012. http://hdl.handle.net/10026.1/913.

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Bovine tuberculosis (TB) is a contagious neglected zoonosis of cattle that is prevalent but under-investigated in Cameroon, hence this study was designed to assess the epidemiology of bovine TB in cattle, risks for M. bovis infection in cattle and humans; and public health implications of zoonotic bovine TB in the highlands of Cameroon. A retrospective study of meat inspection records (1994 – 2010) was done to estimate the prevalence of TB lesions in slaughtered cattle in the North West region. The prevalence of bovine TB and anti-bovine TB antibodies in live cattle based on tuberculin skin te

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Ngema, Xolani Terrance. "Metallic nanoparticles with polymeric shell: A multifunctional platform for application to biosensor." University of the Western Cape, 2018. http://hdl.handle.net/11394/6330.

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Philosophiae Doctor - PhD (Chemistry)<br>Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (MTB) that usually affects the lungs leading to severe coughing, fever and chest pains. It was estimated that over 9.6 million people worldwide developed TB and 1.5 million died from the infectious disease of which 12 % were co-infected with human immunodeficiency virus (HIV) in the year 2015. In 2016 the statistics increased to a total of 1.7 million people reportedly died from TB with an estimated 10.4 million new cases of TB diagnosed worldwide. The development of the effic

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Padiadpu, Jyothi. "An Integrated Systems Biology Approach to Study Drug Resistance in Mycobacteria." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3750.

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Emergence of drug resistance is a major problem in the treatment of many diseases including tuberculosis. To tackle the problem, it is essential to obtain a global perspective of the molecular mechanisms by which bacteria acquire drug resistance. Systems biology approaches therefore become necessary. This work aims to understand pathways to drug resistance and strategies for inhibition of the resistant strains by using a combination of experimental genomics and computational molecular systems approaches. Laboratory evolution of Mycobacterium smegmatis MC2 155 by treatment with isoniazid (INH)

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Padiadpu, Jyothi. "An Integrated Systems Biology Approach to Study Drug Resistance in Mycobacteria." Thesis, 2015. http://etd.iisc.ernet.in/2005/3750.

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Emergence of drug resistance is a major problem in the treatment of many diseases including tuberculosis. To tackle the problem, it is essential to obtain a global perspective of the molecular mechanisms by which bacteria acquire drug resistance. Systems biology approaches therefore become necessary. This work aims to understand pathways to drug resistance and strategies for inhibition of the resistant strains by using a combination of experimental genomics and computational molecular systems approaches. Laboratory evolution of Mycobacterium smegmatis MC2 155 by treatment with isoniazid (INH)

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Kung, Chien-Chia, and 龔建嘉. "Environmental Mycobacterium Flora in Dairy Farms and the Effect on Intradermal Tuberculin Test Results." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/50796501276269704010.

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碩士<br>國立臺灣大學<br>獸醫學研究所<br>99<br>Among the more than 100 known species of the genus Mycobacterium, majority of them are described as “environmental mycobacteria” (EM), present as saprophytes in water or soil worldwide. Several species of EM are known as opportunistic pathogens and may lead to false positive diagnosis of bovine tuberculosis by intradermal tuberculin test (ITT). In Taiwan, ITT is a standard diagnostic tool for tuberculosis eradication program in dairy herds and cattle showing positive reaction are culled immediately. However, from April of 2009 to August of 2010, approximately 32

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Muthivhi, Tshilidzi Neleus. "Phenotypic and genotypic characterisation of mycobacterium tuberculosi strains in relation to the transmission of tuberculosis in South African mines." Thesis, 2000. https://hdl.handle.net/10539/26043.

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A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Doctor of Philosophy.<br>The prevalence of tuberculosis in South African miners is substantially higher than that of in the general population. Through exposure to dust which leads to different degrees of silicosis, and by working in enclosed spaces where coughed out bacilli can survive in droplet nuclei and be inhaled by other workers, miners are especially prone to to become infected with M. tuberculosis and develop the disease. It is not on

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BIANCHI, LEILA. "Evaluation of quantitative interferon-γ responses for the follow up of children exposed to Mycobacterium tuberculosis". Doctoral thesis, 2006. http://hdl.handle.net/2158/618984.

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Anand, Praveen. "Large-Scale Structural Analysis of Protein-ligand Interactions : Exploring New Paradigms in Anti-Tubercular Drug Discovery." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3951.

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BIOLOGICAL processes are governed through specific interactions of macromolecules. The three-dimensional structural information of the macromolecules is necessary to understand the basis of molecular recognition. A large number of protein structures have been determined at a high resolution using various experimental techniques such as X-ray crystallography, NMR, electron microscopy and made publicly available through the Protein Data Bank. In the recent years, comprehending function by studying a large number of related proteins is proving to be very fruitful for understanding their biologica

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Anand, Praveen. "Large-Scale Structural Analysis of Protein-ligand Interactions : Exploring New Paradigms in Anti-Tubercular Drug Discovery." Thesis, 2015. http://etd.iisc.ernet.in/2005/3951.

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BIOLOGICAL processes are governed through specific interactions of macromolecules. The three-dimensional structural information of the macromolecules is necessary to understand the basis of molecular recognition. A large number of protein structures have been determined at a high resolution using various experimental techniques such as X-ray crystallography, NMR, electron microscopy and made publicly available through the Protein Data Bank. In the recent years, comprehending function by studying a large number of related proteins is proving to be very fruitful for understanding their biologica

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Lima, Marília dos Santos. "Tuberculose." Master's thesis, 2016. http://hdl.handle.net/10400.6/5290.

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A tuberculose é uma doença infectocontagiosa predominantemente causada pelo bacilo Mycobacterium tuberculosis, também conhecido por bacilo de Koch. Após a inalação desta micobactéria, os indivíduos podem desenvolver doença, ou por outro lado, permanecer infetados, com uma forma latente de infeção. Os indivíduos com infeção tuberculose latente são assintomáticos, porém encontram-se em risco de desenvolver doença ativa no futuro. O envolvimento pulmonar é o mais frequente, contudo, o bacilo da tuberculose pode atingir qualquer órgão ou sistema do organismo. Conhecida por muitos como “a grande si

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