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Journal articles on the topic 'Mycoplasma pneumoniae (MP)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Meyer Sauteur, Patrick M., Johannes Trück, Annemarie M. C. van Rossum, and Christoph Berger. "Circulating Antibody-Secreting Cell Response During Mycoplasma pneumoniae Childhood Pneumonia." Journal of Infectious Diseases 222, no. 1 (2020): 136–47. http://dx.doi.org/10.1093/infdis/jiaa062.

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Abstract Background We recently demonstrated that the measurement of Mycoplasma pneumoniae (Mp)-specific immunoglobulin (Ig)M antibody-secreting cells (ASCs) improved diagnosis of Mp infection. Here, we aimed to describe Mp ASC kinetics and duration in comparison to conventional measures such as pharyngeal Mp deoxyribonucleic acid (DNA) and serum antibodies. Methods This is a prospective longitudinal study of 63 community-acquired pneumonia (CAP) patients and 21 healthy controls (HCs), 3–18 years of age, from 2016 to 2017. Mycoplasma pneumoniae ASCs measured by enzyme-linked immunospot assay w

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2

Kucharek, Izabela, Klaudia Bednarz, and Adam Jerzy Sybilski. "Unique Presentation of Mycoplasma pneumoniae-Induced Rash and Mucositis with Salivary Gland Inflammation in a Pediatric Patient: A Case Report." Journal of Clinical Medicine 13, no. 16 (2024): 4587. http://dx.doi.org/10.3390/jcm13164587.

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Background: Mycoplasma pneumoniae (MP) is a significant respiratory pathogen leading to community-acquired pneumonia (CAP), especially in children. Up to 30% of confirmed MP cases can develop dermatological symptoms, with Mycoplasma pneumoniae-induced rash and mucositis (MIRM) being a distinct clinical entity marked by mucous membrane inflammation, with or without skin lesions. Methods: This case report describes a 7-year-old girl admitted with fever, stomatitis, conjunctivitis, and skin lesions. On the second day, a painful neck enlargement was observed, with ultrasound confirming bilateral s

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Tong, Lin, Shumin Huang, Chen Zheng, Yuanyuan Zhang, and Zhimin Chen. "Refractory Mycoplasma pneumoniae Pneumonia in Children: Early Recognition and Management." Journal of Clinical Medicine 11, no. 10 (2022): 2824. http://dx.doi.org/10.3390/jcm11102824.

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Refractory Mycoplasma pneumoniae pneumonia (RMPP) is a severe state of M. pneumoniae infection that has attracted increasing universal attention in recent years. The pathogenesis of RMPP remains unknown, but the excessive host immune responses as well as macrolide resistance of M. pneumoniae might play important roles in the development of RMPP. To improve the prognosis of RMPP, it is mandatory to recognize RMPP in the early stages, and the detection of macrolide-resistant MP, clinical unresponsiveness to macrolides and elevated proinflammatory cytokines might be clues. Timely and effective an

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Kim, Chang Ho, and Jaehee Lee. "Mycoplasma pneumoniae Pleural Effusion in Adults." Journal of Clinical Medicine 11, no. 5 (2022): 1281. http://dx.doi.org/10.3390/jcm11051281.

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Parapneumonic effusions often complicate Mycoplasma pneumoniae (MP) pneumonia, contrary to the notion that they are a rare feature of MP infection. Increased research and evidence on MP parapneumonic effusions (MPPE) can help elucidate its clinical significance as one of the variable manifestations of MP infection. This article aims to summarize the existing literature about the clinical characteristics of MPPE in adults and discuss its diagnostic implications from the perspective of pleural fluid analysis. Approximately 20–25% of adult patients with MP pneumonia develop MPPE, and its frequenc

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5

Zhang, Jin. "Review on the laboratory diagnosis of Mycoplasma pneumoniae infection." Infection International 7, no. 3 (2018): 67–74. http://dx.doi.org/10.2478/ii-2018-0030.

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AbstractMycoplasma pneumoniae(MP) is an important pathogen of community-acquired pneumonia in children. As a type of self-limited disease, most MP infections cause mild clinical symptoms, but they can also lead to severe pneumonia or extrapulmonary complications. The resistance rate of MP has increased in recent years. Early and rapid diagnosis of MP infection is important for the treatment and prognosis of the disease. Current methods for diagnosing MP infection include isolation culture, serological diagnosis, and molecular biological diagnosis. This review summarizes the recent research pro

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6

Wang, Jing, Chen Xia, Ashutosh Sharma, Gurjot Singh Gaba, and Mohammad Shabaz. "Chest CT Findings and Differential Diagnosis of Mycoplasma pneumoniae Pneumonia and Mycoplasma pneumoniae Combined with Streptococcal Pneumonia in Children." Journal of Healthcare Engineering 2021 (June 14, 2021): 1–10. http://dx.doi.org/10.1155/2021/8085530.

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Background. In this day and age, 17% of children less than 5 years of age died of pneumonia; it is the common cause of children death. It is one of the main children respiratory infectious diseases, i.e., mycoplasma pneumonia (MP). The imaging examination can be adopted to quickly observe the morphology and scope of the pulmonary lesions and know the effect of disease treatment and subsequent changes in the disease in order to provide a basis for treatment. Therefore, the most commonly applied technology for detecting pneumonia in children is imaging technology, including chest X-ray and CT. O

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7

Rajah, Fatmah Bibi, Rongxiu Zheng, Yuhui Zhou, and Kan Xuan. "Association of Mycoplasma pneumoniae antibody titer level with clinical severity of pneumonia in children." Journal of Pediatric Diseases 1 (August 23, 2017): 24. http://dx.doi.org/10.24294/jpedd.v1i0.105.

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The objectives is to establish a positive correlation between the serology titer of Mycoplasma pneumoniae and the severity of pneumonia, with an emphasis on severity of disease presentation between two different age groups. The research included 110 children admitted at the Tianjin Medical University General Hospital, Tianjin, China, from May 2010 to October 2010. This study included disease history, clinical examination findings, laboratory investigations including Mycoplasma pneumoniae antibody titer (MP-IgM) level as well as imaging, and duration of in-patient treatment. The results of the

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8

Dai, Leilian, Songmei Yang, Yingchao Sun, and Dan Li. "Antibacterial activity of Dactylicapnos scandens extract against Mycoplasma pneumoniae-induced pneumonia in mice: An in vitro and in vivo study." BioResources 20, no. 2 (2025): 3453–63. https://doi.org/10.15376/biores.20.2.3453-3463.

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This study analyzed the antibacterial potential of Dactylicapnos scandens extract (DSE) against Mycoplasma pneumoniae (MP)-induced pneumonia in mice. The DSE was tested for in-vitro antibacterial activity against MP and pharmacological activity in MP-induced pneumonia in mice. DSE showed significant in-vitro antibacterial activity against MP. It improved the level of nitric oxide, and myeloperoxidase, including the lung weight index near to control in a dose-dependent manner in experimental animals. The levels of glutathione and superoxide dismutase were found significantly increased in DSE tr

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9

Cho, Hye-Kyung. "Consideration in treatment decisions for refractory Mycoplasma pneumoniae pneumonia." Clinical and Experimental Pediatrics 64, no. 9 (2021): 459–67. http://dx.doi.org/10.3345/cep.2020.01305.

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Mycoplasma pneumoniae (MP) is the most common cause of childhood bacterial pneumonia. Although macrolide is known to be effective as a first-line therapy, the proportion of macrolide resistance in MP pneumonia has strikingly increased during recent 2 decades in East Asia. This is challenging to physicians since they have to decide more often whether to use secondary treatment. Diagnostic methods to detect macrolide-resistance of MP are currently not available in Korean hospitals. Even in the diagnosis of MP infection, both serologic and molecular test have limitation: inability to differentiat

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10

Hu, Liuyang, Xiuri Wang, Donglin Cao, Qiuchen Cheng, and Qiong Li. "Establishment and Performance Evaluation of Multiplex PCR-Dipstick DNA Chromatography for Mycoplasma pneumoniae and Chlamydia pneumoniae Rapid Detection." Canadian Journal of Infectious Diseases and Medical Microbiology 2023 (September 28, 2023): 1–7. http://dx.doi.org/10.1155/2023/6654504.

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Background and Objective. Mycoplasma pneumoniae (MP) and Chlamydia pneumoniae (CP) infections are becoming increasingly prominent in respiratory infections. This study established a rapid, simple, sensitive, accurate multiplex PCR-dipstick DNA chromatography assay for Mycoplasma pneumoniae and Chlamydia pneumoniae detection. Methods. Nasopharyngeal swab samples of 300 children with an acute respiratory tract infection were detected by a multiplex PCR-dipstick chromatography assay, and the results were compared with the DNA sequencing and serum IgM antibody assay. Results. A multiplex PCR-dipst

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Lee, Hui-Yu, Chun-Chia Chen, Chia-Chen Pi, and Chun-Jen Chen. "Aspergillus oryzae Fermentation Extract Alleviates Inflammation in Mycoplasma pneumoniae Pneumonia." Molecules 28, no. 3 (2023): 1127. http://dx.doi.org/10.3390/molecules28031127.

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The filamentous fungus Aspergillus oryzae, also known as koji mold, has been used for centuries in the production of fermented foods in East Asia. A. oryzae fermentation can produce enzymes and metabolites with various bioactivities. In this study, we investigated whether A. oryzae fermentation extract (AOFE) has any effect on Mycoplasma pneumoniae (Mp) pneumonia. We performed solid-state fermentation of A. oryzae and obtained the ethanol extract. AOFE was analyzed by HPLC, and the major component was identified to be kojic acid. In vitro, AOFE suppressed Mp growth and invasion into A549 lung

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Liu, Li, Shobha Maharjan, Jia-Liang Sun, Yan-Chun Li, and Huan-Ji Cheng. "Prevalence and clinical characteristics of septicemia in children with Mycoplasma pneumoniae pneumonia." Journal of International Medical Research 49, no. 6 (2021): 030006052110217. http://dx.doi.org/10.1177/03000605211021733.

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Background Mycoplasma pneumoniae (MP) pneumonia in children can be challenging to treat, and the impact of MP blood infection is unclear. The present study aims to determine the prevalence and clinical characteristics of MP septicemia among pediatric patients. Methods Children hospitalized at our center for MP pneumonia between October 2017 and June 2018 were included. Healthy controls visiting our outpatient clinic for regular physical examinations were also enrolled. MP was detected by real-time polymerase chain reaction (qPCR) analysis of plasma and peripheral blood mononuclear cell (PBMC)

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13

Zhong, Anqiao. "Recent Progress in Mycoplasma pneumoniae Infection." Infection International 4, no. 2 (2015): 31–34. http://dx.doi.org/10.1515/ii-2017-0102.

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AbstractMycoplasma pneumoniae(Mp) is a definite respiratory pathogen affecting people of all ages. This organism is adsorbed on host cell surface through extreme adherent organelles, generating peroxide ions and possible exotoxins. Mp may directly invade host cells and cause latent infections. Induced immunoreactive injury is one of the main factors resulting in clinical symptoms of Mp infection. Polymerase chain reaction (PCR) and serological detection should be combined for diagnosis of Mp infection when nasopharyngeal and oropharyngeal specimens are simultaneously obtained and detected by P

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14

Lee, Eun, and Yun Young Lee. "Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia." Journal of Clinical Medicine 10, no. 6 (2021): 1154. http://dx.doi.org/10.3390/jcm10061154.

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The prevalence of refractory Mycoplasma pneumoniae (MP) pneumonia is increasing. The present study aimed to identify the predictive factors of responses to treatment of MP pneumonia in children. A total of 149 children were diagnosed with MP pneumonia, of whom 56 were included in the good response group, 75 children in the slow response group, and 18 children in no response or progression group. Data on the clinical, laboratory, and radiologic features were retrospectively obtained through medical chart reviews. The severity of pneumonia, based on the extent of pneumonic lesions on chest x-ray

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Zhou, Wenxiang, Jinglong Chen, Zhimin Xi, Yanyan Shi, Libo Wang, and Aizhen Lu. "Characteristics of Lung Microbiota in Children’s Refractory Mycoplasma pneumoniae Pneumonia Coinfected with Human Adenovirus B." Canadian Journal of Infectious Diseases and Medical Microbiology 2022 (January 17, 2022): 1–8. http://dx.doi.org/10.1155/2022/7065890.

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Background. Both M. pneumoniae and human adenovirus (HAdV) are common causative agents of lower respiratory tract infection in children; nonetheless, the lung microbiota in patients with coinfection of HAdV and M. pneumoniae remain unexplored. Methods. Thirty-two children, diagnosed with refractory M. pneumoniae pneumonia (RMPP), entered into the one-year study from July 1, 2019 to June 30, 2020. Among them, twenty-one entered into the M. pneumoniae monoinfection (MP) group and eleven entered into the M. pneumoniae and HAdV coinfection (MP&ADV) group. The characteristics of the clinical fi

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Wu, Yan, Guikai Duan, Minggang Cheng, Weiqing Wu, Qin Yu, and Dapeng Yu. "Comparison of multiple detection methods of Mycoplasma pneumoniae antibody for the early diagnosis of pediatric mycoplasma pneumonia." European Journal of Inflammation 17 (January 2019): 205873921983871. http://dx.doi.org/10.1177/2058739219838712.

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Mycoplasma pneumoniae pneumonia (MPP) is a common disease in infants and young children. MPP can also be a potential cause of healthcare-associated pneumonia. However, it is challenging to make an accurate diagnosis in a timely fashion. Our goal is to determine the assay consistencies of acridinium ester chemiluminescence immunoassay (AECLIA) and gelatin particle agglutination (GPA) test for the detection of Mycoplasma pneumoniae (MP) antibody. In this study, a total of 1404 children with suspected MPP were enrolled. Among them, 130 were diagnosed as MPP positive by mycoplasma culture, and 186

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Blau, K., S. Abraham, S. Heyne, et al. "Mycoplasmen-assoziierte Haut- und Schleimhautveränderungen." Aktuelle Dermatologie 44, no. 06 (2018): 260–64. http://dx.doi.org/10.1055/a-0589-4731.

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ZusammenfassungIm Zusammenhang mit einer Mycoplasma pneumoniae-Infektion können erosive Haut- und Schleimhautveränderungen auftreten. Diese wurden als Erythema multiforme, Steven-Johnson-Syndrom oder toxische epidermale Nekrolyse beschrieben. In den meisten Fällen dominiert eine ausgeprägte Mukositis, wohingegen die Hautveränderungen des restlichen Integuments meist nur sehr spärlich auftreten und als atypische Kokarden beschrieben werden.Einige Autoren postulieren ein eigenständiges dermatologisches Krankheitsbild, das durch Mycoplasma pneumoniae induziert wird und vordergründig zu einer Muko

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Kim, Seo-Hee, Eun Lee, Eun-Song Song, and Yun-Young Lee. "Clinical Significance of Pleural Effusion in Mycoplasma pneumoniae Pneumonia in Children." Pathogens 10, no. 9 (2021): 1075. http://dx.doi.org/10.3390/pathogens10091075.

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The clinical significance of pleural effusion in Mycoplasma pneumoniae (MP) pneumonia in children has not yet been elucidated. Herein, we investigated the clinical implications of pleural effusion in children with MP pneumonia. Overall, 150 children with MP pneumonia transferred to a tertiary hospital were enrolled in this study. Information on their clinical, laboratory, and radiological features was retrospectively obtained from medical chart reviews. In total, 24 (16.0%) children had pleural effusion at the time of admission. The duration of fever and length of hospitalization were signific

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19

Li, Fengtan. "New Research Progress in Mycoplasma pneumoniae Infection." Infection International 4, no. 4 (2015): 91–95. http://dx.doi.org/10.1515/ii-2017-0114.

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AbstractAs an important pathogen of respiratory tract infection,Mycoplasma pneumoniae (MP)may not only lead to primary atypical pneumonia but also cause systemic organ conditions. MP causes respiratory tract infection among school-age children and is also an important infectious agent for adult respiratory tract infection. Intensive studies on roles ofMPinfection on the innate immune system significantly aid development of targeted therapy drugs. Epidemic studies on associated symptoms also help in clinical prevention and diagnosis and show importance to personalized treatment utilizing differ

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20

Kálmán, Réka, Tamás Pregun, Kristóf Rodler, László Imre, and Ágnes Kerényi. "Mycoplasma pneumoniae fertőzéssel összefüggésbe hozható intraocularis gyulladás (esetismertetés és irodalmi áttekintés)." Szemészet 161, no. 2 (2024): 88–93. https://doi.org/10.55342/szemhungarica.2024.161.2.88.

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Célkitűzés: Mycoplasma pneumoniae (MP) lehetséges kóroki szerepének felvetése az intraocularis gyulladásokban két eset ismertetése kapcsán. Esetismertetés: A 38 éves nőbeteg egyik szemén, egy hónapja észlelt látásromlását felső légúti hurut előzte meg. A vizsgálatok vitritist, szerózus retinaleválással (SRD serous retinal detachment) járó uveitist, vasculitist jeleztek. A kórfolyamatot szerológiai vizsgálatok alapján feltételezhető, közelmúltban lezajlott MP-fertőzéssel hoztuk összefüggésbe. Doxycyclin- és metilprednisolon-terápia mellett az üvegtest tisztult, az SRD megszűnt, a dezorganizált

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Xu, Changdi, Huan Deng, Jiamin Zhang, et al. "Mutations in domain V of Mycoplasma pneumoniae 23S rRNA and clinical characteristics of pediatric M. pneumoniae pneumonia in Nanjing, China." Journal of International Medical Research 49, no. 6 (2021): 030006052110163. http://dx.doi.org/10.1177/03000605211016376.

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Objective To investigate the prevalence of mutations in domain V of Mycoplasma pneumoniae (MP) 23S ribosomal RNA (rRNA) and the clinical characteristics of pediatric MP pneumonia (MPP) in Nanjing, China. Methods Domain V of 23S rRNA was sequenced in MP strains collected from children diagnosed with MPP in Nanjing. Clinical and laboratory data were obtained. Results Among the 276 MP strains, 255 (92.39%) harbored mutations, primarily A2063G in domain V of MP 23S rRNA. When children were stratified according to the presence or absence of mutations, no significant differences were found in sex, a

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Neeser, Olivia L., Tanja Vukajlovic, Laetitia Felder, et al. "A high C-reactive protein/procalcitonin ratio predicts Mycoplasma pneumoniae infection." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 10 (2019): 1638–46. http://dx.doi.org/10.1515/cclm-2019-0194.

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Abstract Background Discriminating Mycoplasma pneumoniae (MP) from Streptococcus pneumoniae (SP) and viral etiologies of community-acquired pneumonia (CAP) is challenging but has important implications regarding empiric antibiotic therapy. We investigated patient parameters upon hospital admission to predict MP infection. Methods All patients hospitalized in a tertiary care hospital between 2013 and 2017 for CAP with a confirmed etiology were analyzed using logistic regression analyses and area under the receiver operator characteristics (ROC) curves (AUC) for associations between demographic,

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de Azevedo, Leonardo C., Eduardo S. C. Faveret, and Eduardo J. B. Zayen. "Cerebrovascular accident related to mycoplasma pneumoniae (MP)." Pediatric Neurology 8, no. 5 (1992): 373–74. http://dx.doi.org/10.1016/0887-8994(92)90202-a.

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Yuan, Chen, Fang-Mei Min, Yin-Jie Ling, et al. "Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children." Combinatorial Chemistry & High Throughput Screening 21, no. 10 (2019): 749–54. http://dx.doi.org/10.2174/1386207322666190111112946.

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Aim: To analyze the clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia (MP) in Chinese patients, providing valuable information for the management of patients with MP. Methods: A total of 120 children who were hospitalized in The First Hospital of Huzhou between January and December 2016 for respiratory tract infection due to M. pneumoniae were enrolled in this study. Infection with M. pneumoniae was confirmed by ELISA for M. pneumoniae antibody, PCR, and throat culture. Antibiotic resistance was measured from the minimum inhibitory concentrations (MICs) of a

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Wei, Hongping, Chunyan Wang, Lili Ding, and Min Wu. "The Diagnostic Value of High-Resolution Computed Tomography Features Combined with Mycoplasma Pneumoniae Ribonucleic Acid Load Detection for Refractory Mycoplasma Pneumonia." Contrast Media & Molecular Imaging 2022 (May 4, 2022): 1–9. http://dx.doi.org/10.1155/2022/6460865.

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The aim of this study was to investigate the value of high-resolution computed tomography (CT) images and mycoplasma pneumoniae (MP) ribonucleic acid (RNA) load detection in the early diagnosis of refractory mycoplasma pneumoniae (RMP) and provide more methods for the diagnosis and treatment of RMP. Seventy children with MP were divided into the RMP group (H1 group, 31 cases) and the MP group (H2 group, 39 cases) according to pathological findings, and all of them underwent CT scanning. MP-RNA load and genotype distribution were analyzed in both groups, and the diagnostic efficacy of CT combin

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Rodman Berlot, Jasna, Tatjana Mrvič, Mitja Košnik, and Darja Keše. "The Association between Mycoplasma pneumoniae Genotype and Cutaneous Disease." Microorganisms 11, no. 1 (2023): 205. http://dx.doi.org/10.3390/microorganisms11010205.

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Mycoplasma pneumoniae (Mp) can cause several extrapulmonary manifestations, most frequently dermatological ones. It is largely unknown whether Mp genotype determines Mp-induced cutaneous disease. The aim of our study was to assess the association between Mp genotype and this clinical outcome. We performed a retrospective study of children referred with signs of acute Mp infection from 1 January 2014 to 31 December 2014. We compared the characteristics of children presenting as cutaneous disease, upper (URTI) and lower respiratory tract infection (LRTI). In addition, we separately analyzed the

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Liu, Xiuxiu, Mingjing Wang, Qianna Kan, Yan Lin, and Zhiyan Jiang. "Qingfei Tongluo Formula Mitigates Mycoplasma pneumoniae Infection via the PERK Signaling Pathway." Disease Markers 2022 (December 6, 2022): 1–12. http://dx.doi.org/10.1155/2022/9340353.

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Mycoplasma pneumoniae pneumonia (MPP) is usually found in school-aged children and relapses easily because of antibiotic resistance. The Qingfei Tongluo formula (QTF) is a clinically used traditional Chinese medicine to treat MPP. Our previous study demonstrated that QTF exhibited ameliorative effects on the experimental MPP mice model. In this study, the function and underlying QTF mechanism in MPP was attempted to be further explored. Mycoplasma pneumoniae (MP) was applied to infect A549 cells and BALB/c mice to mimic MPP in vitro and in vivo. Cytokine release and reactive oxygen species (RO

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Zhang, Fengxia, Jiamin Zhang, Feng Liu та ін. "Attenuated lncRNA NKILA Enhances the Secretory Function of Airway Epithelial Cells Stimulated by Mycoplasma pneumoniae via NF-κB". BioMed Research International 2021 (26 березня 2021): 1–9. http://dx.doi.org/10.1155/2021/6656298.

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The secretory function of airway epithelial cells is important in the pathogenesis of Mycoplasma pneumoniae pneumonia (MPP). To investigate the regulatory function of NKILA (nuclear factor-κB (NF-κB) interacting long noncoding RNA (lncRNA)) in MPP, we first detected NKILA as well as the concentration of interleukin 8 (IL-8) and tumor necrosis factor-α (TNF-α) in bronchoalveolar lavage fluid of children with MPP. Then, NKILA was knocked down in epithelial cells to investigate its effect on their secretory function. The results suggested that NKILA was downregulated in children with MPP, while I

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Aizawa, Yuta, Tomohiro Oishi, Shinya Tsukano, Tetsuo Taguchi, and Akihiko Saitoh. "Clinical utility of loop-mediated isothermal amplification for rapid diagnosis of Mycoplasma pneumoniae in children." Journal of Medical Microbiology 63, no. 2 (2014): 248–51. http://dx.doi.org/10.1099/jmm.0.068288-0.

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Loop-mediated isothermal amplification (LAMP) is a cost-effective and rapid method for identifying Mycoplasma pneumoniae (MP). We investigated the utility of the LAMP assay in diagnosing MP pneumonia among children in a clinical setting. In this prospective study, the cause of community-acquired pneumonia was evaluated in 111 patients for whom MP was the suspected pathogen. All participants were patients at a city hospital in Japan between April 2012 and September 2012. Throat swabs for the LAMP assay were obtained at admission, and paired serum samples to measure antibody titres to MP by part

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HIGUCHI, Maria de Lourdes, Marilia Harumi HIGUCHI-DOS-SANTOS, Humberto PIERRI, et al. "Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves." Revista do Instituto de Medicina Tropical de São Paulo 44, no. 4 (2002): 209–12. http://dx.doi.org/10.1590/s0036-46652002000400005.

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Aortic Valve Stenosis (AVS) has been explained as an atherosclerotic process of the valve as they often exhibit inflammatory changes with infiltration of macrophages, T lymphocytes and lipid infiltration. The present study investigated whether the bacteria Chlamydia pneumoniae (CP) and Mycoplasma pneumoniae (MP), detected previously in atherosclerotic plaques, are also present in AVS. Ten valves surgically removed from patients with AVS were analyzed by immunohistochemistry, in situ hybridization, and electron microscopy. The mean and standard deviation of the percentage areas occupied by CP a

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Yang, Eun-Ae, Hyun-Mi Kang, Jung-Woo Rhim, Jin-Han Kang, and Kyung-Yil Lee. "Early Corticosteroid Therapy for Mycoplasma pneumoniae Pneumonia Irrespective of Used Antibiotics in Children." Journal of Clinical Medicine 8, no. 5 (2019): 726. http://dx.doi.org/10.3390/jcm8050726.

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Antibiotics’ effect on Mycoplasma pneumoniae (MP) infection still remains controversial. A prospective study of 257 children with MP pneumonia during a recent epidemic (2015–2016) was conducted. All MP pneumonia patients were treated with corticosteroids within 24–36 h after admission. Initially, oral prednisolone (1 mg/kg) or intravenous methylprednisolone (IVMP; 1–2 mg/kg) was administered for mild pneumonia patients, and IVMP (5–10 mg/kg/day) for severe pneumonia patients. If patients showed a persistent fever for 36–48 h or disease progression, additive IVMP (5 mg/kg or 10 mg/kg) was given

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Oishi, Tomohiro, and Kazunobu Ouchi. "Recent Trends in the Epidemiology, Diagnosis, and Treatment of Macrolide-Resistant Mycoplasma pneumoniae." Journal of Clinical Medicine 11, no. 7 (2022): 1782. http://dx.doi.org/10.3390/jcm11071782.

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Among Mycoplasma pneumoniae (MP) is one of the major pathogens causing lower respiratory tract infection. Macrolide-resistant Mycoplasma pneumoniae (MRMP) isolates have been increasing and has become a global concern, especially in East Asian countries. This affects the treatment of MP infection; that is, some patients with MRMP infections fever cannot be controlled despite macrolide therapy. Therefore, alternative therapies, including secondary antimicrobials, including tetracyclines, fluoroquinolones, or systemic corticosteroids, were introduced. However, there are insufficient data on these

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Biagi, Carlotta, Alessandra Cavallo, Alessandro Rocca, et al. "Pulmonary and Extrapulmonary Manifestations in Hospitalized Children with Mycoplasma Pneumoniae Infection." Microorganisms 9, no. 12 (2021): 2553. http://dx.doi.org/10.3390/microorganisms9122553.

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Mycoplasma pneumoniae (MP) is one of the main causes of both upper and lower respiratory infections in school-aged children, accounting for up to 40% of community-acquired pneumonia. Younger children are also affected, and extrapulmonary manifestations have been recently reported in the pediatric population. We carried out a retrospective analysis of MP-positive patients admitted to the Pediatric Emergency Unit of S. Orsola Malpighi University Hospital in Bologna, the largest tertiary pediatric referral center in the Emilia–Romagna region, Northern Italy, between 2012 and 2020. We identified 1

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Tian, Fang, Li-Ping Chen, Gang Yuan, Ai-Min Zhang, Yu Jiang та Shuang Li. "Differences of TNF-α, IL-6 and Gal-3 in lobar pneumonia and bronchial pneumonia caused by mycoplasma pneumoniae". Technology and Health Care 28, № 6 (2020): 711–19. http://dx.doi.org/10.3233/thc-192011.

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OBJECTIVE: To investigate the differences of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and galectin-3 concentrations in lobar pneumonia and bronchopneumonia induced by mycoplasma pneumoniae (MP) in children and to explore these related factors predicting the severity of MP. METHODS: A total of 148 children with mycoplasma pneumoniae pneumonia (MPP) and 32 healthy controls were analyzed from March 2017 to August 2018 in our province. Clinical information was collected from the hospitalized MP patients. The 148 patients with MPP were divided into two groups: lobar pneumonia group and

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Slauer, Ryan D., Ahmad Mourad, Govind Krishnan, and Colby Feeney. "Mycoplasma pneumoniae-associated diffuse alveolar haemorrhage: an atypical presentation of a prevalent pathogen." BMJ Case Reports 15, no. 4 (2022): e248273. http://dx.doi.org/10.1136/bcr-2021-248273.

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A transgender man in his late teens presented with signs of multisystem disease, including hepatitis, mucositis and bone marrow suppression. He later developed dyspnoea, leucocytosis and bilateral pulmonary infiltrates on chest radiograph. He was treated for community-acquired pneumonia. After several days of treatment, he developed hypoxaemic respiratory failure due to bronchoscopy-confirmed diffuse alveolar haemorrhage (DAH). The differential diagnosis and workup were extensive, and he was ultimately treated with intravenous steroids and five sessions of plasmapheresis for a presumed autoimm

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Pury, Selene, María Soledad Álvarez, and María Cecilia García Oro. "Detección molecular de Mycoplasma pneumoniae en muestras respiratorias de niños hospitalizados." Revista de la Facultad de Ciencias Médicas de Córdoba 80, no. 1 (2023): 20–24. http://dx.doi.org/10.31053/1853.0605.v80.n1.37514.

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Introducción: Actualmente se encuentra reportado que la infección por Mycoplasma pneumoniae (MP) puede darse en edades tempranas de la vida.Objetivo: Describir los hallazgos de la detección molecular de MP en secreciones respiratorias de pacientes que requirieron internación por infección respiratoria aguda, en un hospital pediátrico. Población y métodos: La recolección de datos se realizó mediante revisión de historias clínicas y la correlación estadística mediante test de chi-cuadrado. Se incluyeron 919 pacientes de un mes a catorce años y once meses de edad que requirieron internación por i

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Zhu, Zemin, Ziaur Rahman, Muhammad Aamir, et al. "Insight into TLR4 receptor inhibitory activity via QSAR for the treatment of Mycoplasma pneumonia disease." RSC Advances 13, no. 3 (2023): 2057–69. http://dx.doi.org/10.1039/d2ra06178c.

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Guo, Shanshan, Lei Bao, Tiange Qu, et al. "Ameliorative Effects of Infantile Feire Kechuan Oral Solution on Mycoplasma Pneumoniae Pneumonia in Infant Mouse and Rat Models." Evidence-Based Complementary and Alternative Medicine 2018 (September 17, 2018): 1–10. http://dx.doi.org/10.1155/2018/8139040.

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Mycoplasma pneumoniae (MP) infection is a major pathogen of community-acquired pneumonia (CAP) in children worldwide. Infantile Feire Kechuan Oral Solution (IFKOS) has been used for the treatment of MP pneumonia clinically in China for many years. The present study was designed to investigate the therapeutic effect of IFKOS on MP pneumonia and explore the potential mechanism of the actions. The infant BALB/c mouse and Wistar rat models of MP infection were successfully established to confirm the therapeutic effects of IFKOS, followed by assays for related cytokines and investigations of the Ig

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Jin, Peng, Lin-Sheng Zhao, Tong-Qiang Zhang, Han Di, and Wei Guo. "Establishment of a Mouse Model of Mycoplasma pneumoniae-Induced Plastic Bronchitis." Microorganisms 12, no. 6 (2024): 1132. http://dx.doi.org/10.3390/microorganisms12061132.

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Plastic bronchitis (PB) constitutes a life-threatening pulmonary disorder, predominantly attributed to Mycoplasma pneumoniae (MP) infection. The pathogenic mechanisms involved remain largely unexplored, leading to the absence of reliable approaches for early diagnosis and clear treatment. Thus, the present investigation aimed to develop an MP-induced mouse model of PB, thereby enhancing our understanding of this complex condition. In the first stage, healthy BALB/c mice were utilized to investigate the optimal methods for establishing PB. This involved the application of nebulization (15–20 mi

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Liu, Congcong, Rui Wang, Shuyi Ge, Binding Wang, Siman Li, and Bohua Yan. "Research status and challenges of Mycoplasma pneumoniae pneumonia in children: A bibliometric and visualization analysis from 2011 to 2023." Medicine 103, no. 11 (2024): e37521. http://dx.doi.org/10.1097/md.0000000000037521.

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Background: Mycoplasma pneumoniae (MP) infections occur in regional outbreaks every 3 to 7 years, lasting up to 2 years. Since this fall, there has been a significant rise in MP infections among children in China, indicating a regional epidemiological trend that imposes an increased national public health burden. To date, bibliometric methods have not been applied to studies on MP infection in children. Methods: We searched for all relevant English publications on MP pneumonia in children published from 2011 to 2023 using Web of Science. Analytical software tools such as Citespace and VOSviewe

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Segovia, Jesus A., Te-Hung Chang, Lavanya Pandranki, Thirumalai R. Kannan, and Joel B. Baseman. "NLRP3 plays a major role in inflammasome activation during Mycoplasma pneumoniae infection." Journal of Immunology 196, no. 1_Supplement (2016): 62.4. http://dx.doi.org/10.4049/jimmunol.196.supp.62.4.

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Abstract Mycoplasma pneumoniae (Mp) is a common bacterial pathogen that causes acute and chronic airway diseases in humans and is a leading cause of bacterial community-acquired pneumonia and is implicated in initiation and exacerbation of asthma. Mp infection triggers a strong inflammatory response driven by interleukin-1β (IL-1β). Mp produces the Community-Acquired Respiratory Distress Syndrome (CARDS) toxin, which is highly expressed during infection and specifically activates the nod-like receptor family protein 3 (NLRP3) inflammasome. However, the significance of the NLRP3 inflammasome du

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Khamitov, R. F., V. G. Novozhenov, I. G. Mustafin, et al. "The level of antibodies to Chlamydia pneumoniae and Mycoplasma pneumoniae among patients with bronchial asthma." Kazan medical journal 81, no. 5 (2022): 386–88. http://dx.doi.org/10.17816/kazmj96293.

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The level of antibodies to chlamydia pneumoniae (Cp) and Micoplasma pneumoniae (Mp) in 65 patients with bronchial asthma in the clinical remission phase is studied. To reveal antibodies to Cp the indirect immunofluorescence reaction was used, to reveal antibodies to Mp the indirect immunoenzymic analysis method was used. In diagnostic titer the antibodies to Cp were found in 23 patients and antibodies to Mp were found in 25 patients (38%) of 65. In 6 (9,2%) of them the antibodies to Cp were also determined. In patients of seropositive and seronegative groups the differences on some anamnestic

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Rodman Berlot, Jasna, Špela Dolenc, Uroš Krivec, and Darja Keše. "Clinical, Laboratory, and Radiographic Features Can Help Predict Mycoplasma pneumoniae Lower Respiratory Tract Infection in Children." Microorganisms 11, no. 5 (2023): 1358. http://dx.doi.org/10.3390/microorganisms11051358.

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Mycoplasma pneumoniae (Mp) is a common cause of lower respiratory tract infection (LRTI) in children that is difficult to distinguish from LRTI of other etiologies. We aimed to determine if a combination of clinical, laboratory, and chest radiographic features can help identify patients at higher risk of Mp LRTI. We reviewed medical charts of children referred to our tertiary hospital with suspected acute mycoplasmal LRTI. Pharyngeal swabs obtained from patients were tested by Mp PCR. We compared epidemiological and clinical data of children with positive and negative Mp PCR results. In additi

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Wu, Lina, Maosheng Ye, Xiaosong Qin, Yong Liu, Zhe Lv, and Rui Zheng. "Diagnostic value of quantitative MP-IgG for Mycoplasma pneumoniae pneumonia in adults." Clinica Chimica Acta 503 (April 2020): 76–83. http://dx.doi.org/10.1016/j.cca.2020.01.004.

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Du, Dong, Shuping Liao, Yan Wu, et al. "Serological Analysis and Drug Resistance of Chlamydia pneumoniae and Mycoplasma pneumoniae in 4500 Healthy Subjects in Shenzhen, China." BioMed Research International 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/3120138.

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Objective. To understand the prevalence and distribution of Chlamydia pneumoniae (CP) and Mycoplasma pneumoniae (MP) in the population and to provide a basis for the prevention and treatment of respiratory tract infection. Methods. This study included a total of 4500 healthy subjects who were given physical examination in Shenzhen People’s Hospital from January to December in 2016. Venous blood was drawn from people to detect the MP- and CP-specific IgG and IgM in the serum using chemiluminescence immunoassay (CLIA). The relationship of MP and CP infections with patient age, seasons, and perce

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Jeon, Ha Eun, Hyun Mi Kang, Eun Ae Yang, et al. "Early Confirmation of Mycoplasma pneumoniae Infection by Two Short-Term Serologic IgM Examination." Diagnostics 11, no. 2 (2021): 353. http://dx.doi.org/10.3390/diagnostics11020353.

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The aim of the present study is to re-evaluate the clinical application of two-times serologic immunoglobulin M (IgM) tests using microparticle agglutination assay (MAA), an enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR) assay in diagnosing Mycoplasma pneumoniae (MP) infection. A retrospective analysis of 62 children with MP pneumonia during a recent epidemic (2019–2020) was conducted. The MAA and ELISA immunoglobulin M (IgM) and IgG measurements were conducted twice at admission and around discharge, and MP PCR once at presentation. Diagnostic rates in each tes

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Lee, Hyunju, Youn Young Choi, Young Joo Sohn, et al. "Clinical Efficacy of Doxycycline for Treatment of Macrolide-Resistant Mycoplasma pneumoniae Pneumonia in Children." Antibiotics 10, no. 2 (2021): 192. http://dx.doi.org/10.3390/antibiotics10020192.

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In areas with high prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia, treatment in children has become challenging. This study aimed to analyze the efficacy of macrolides and doxycycline with regard to the presence of macrolide resistance. We analyzed children with MP pneumonia during the two recent epidemics of 2014–2015 and 2019–2020 from four hospitals in Korea. Nasopharyngeal samples were obtained from children with pneumonia for MP cultures and polymerase chain reaction (PCR). Macrolide resistance was determined by the analysis of 23S rRNA gene transition. Time to d

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Wang, Anyan, Zhenhua Wu, Yuhang Huang, et al. "A 3D-Printed Microfluidic Device for qPCR Detection of Macrolide-Resistant Mutations of Mycoplasma pneumoniae." Biosensors 11, no. 11 (2021): 427. http://dx.doi.org/10.3390/bios11110427.

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Mycoplasma pneumonia (MP) is a common respiratory infection generally treated with macrolides, but resistance mutations against macrolides are often detected in mycoplasma pneumoniae in China. Rapid and accurate identification of mycoplasma pneumoniae and its mutant type is necessary for precise medication. This paper presents a 3D-printed microfluidic device to achieve this. By 3D printing, the stereoscopic structures such as microvalves, reservoirs, drainage tubes, and connectors were fabricated in one step. The device integrated commercial polymerase chain reaction (PCR) tubes as PCR chambe

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Liang, S., and HB Liu. "Severe mycoplasma pneumoniae pneumonia combined with cold agglutinin disease and pulmonary embolism in childhood: A case report and review of the literature." African Journal of Reproductive Health 28, no. 11 (2024): 205–15. https://doi.org/10.29063/ajrh2024/v28i11.20.

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This was a case report and literature review, aimed to strengthen the understanding and therapy of mycoplasma pneumoniae (MP) pneumonia combined with cold agglutinin disease and pulmonary embolism in children. A 7-year-old boy was taken to the hospital with fever for 7 days, cough for 5 days, and recurrent cyanosis at the extremities of one day duration. Pulmonary artery computed tomography angiography (CTA) showed pulmonary embolism, double pneumonia, and pleural effusion. Mycoplasma (MP) antibody IgM, Coombs test, and anti C3d were positive while anti-IgG was negative. After treatment, the p

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Zhang, Zhinan, Yixian Zhang, and Bihe Zeng. "Knockdown of ITIH4 reduces inflammatory damage and apoptosis of A549 cells induced by Mycoplasma pneumoniae through NLRP3 inflammation." Allergologia et Immunopathologia 52, no. 4 (2025): 14–20. https://doi.org/10.15586/aei.v53i4.1367.

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Background: Mycoplasma pneumoniae (MP) is a leading cause of community-acquired respiratory infections in pediatric patients. This study aimed to investigate whether the pro-inflammatory function of inter-alpha-trypsin inhibitor heavy chain (ITIH4) contributes to the pathogenesis of MP-induced pneumonia. Method: A549 cells were stimulated with MP to model pneumonia in vitro. ITIH4 expression was knocked down in A549 cells using lentiviral transfection. Cell viability was measured using the Cell Counting Kit-8 (CCK-8) assay, while cell apoptosis was assessed via flow cytometry. The concentratio

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