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Journal articles on the topic 'Myocardial diseases, Primary'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

SHAMKINA, AYGUL R., AIGUL I. AKHMETZIANOVA, AIRAT R. GAZIEV, and MAXIM A. MAKAROV. "PREVALENCE OF INAPPROPRIATE LEFT VENTRICULAR MASS IN PATIENTS WITH VARIOUS DISEASES." Bulletin of Contemporary Clinical Medicine 16, no. 6 (2023): 130–40. http://dx.doi.org/10.20969/vskm.2023.16(6).130-140.

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Abstract. Introduction. According to the inappropriate left ventricular mass concept proposed by G. de Simone et al. (1998), in some cases, an increment in the left ventricular myocardium mass occurs inadequately to the hemodynamic load of high blood pressure. Studying the prevalence and interrelation of disproportionately high left ventricular myocardia ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2023 Том 16, вып. 6 131ОБЗОРЫ mass continues to remain topical to the present, due to the increased risk of cardiovascular events among affected people, and at the same time independently of the presenc

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Tantry, Udaya S., Kevin P. Bliden, Rahul Chaudhary, Marko Novakovic, Amit Rout, and Paul A. Gurbel. "Vorapaxar in the treatment of cardiovascular diseases." Future Cardiology 16, no. 5 (2020): 373–84. http://dx.doi.org/10.2217/fca-2019-0090.

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Vorapaxar specifically and effectively inhibits protease activated receptor-1 and may reduce thrombin-mediated ischemic events without interfering primary hemostasis. In the TRA-2P-TIMI 50 trial, vorapaxar reduced the risk of primary ischemic outcome but with increased bleeding risk. In the post hoc analysis, in patients with a history of myocardial infarction, peripheral artery disease, the net clinical outcome favored vorapaxar therapy with 10% reduction in cardiovascular death, myocardial infarction, stroke, urgent coronary revascularization and moderate or severe bleeding. Based on these f

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Lutokhina, Yu A., O. V. Blagova, E. A. Kogan, et al. "Prevalence of myocarditis and its contribution to the course of primary myocardial hypertrophy." Russian Journal of Cardiology 28, no. 11 (2023): 5528. http://dx.doi.org/10.15829/1560-4071-2023-5528.

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Aim. To assess the incidence of myocarditis in patients with primary myocardial hypertrophy and to study its contribution to the disease course.Material and methods. The study included 100 patients with primary left ventricular myocardial hypertrophy, 52 men and 48 women (mean age, 51,5±15,7 years; followup period 10,4 [2,1; 36,1] months). All patients underwent electrocardiography, 24-hour electrocardiographic monitoring, echocardiography, as well as DNA analysis (n=96), myocardium pathological study (n=29), cardiac magnetic resonance imaging (n=31), cardiac multislice computed tomography (n=

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Sarda, L., P. Assayag, E. Palazzo, et al. "111Indium antimyosin antibody imaging of primary myocardial invovement in systemic diseases." Annals of the Rheumatic Diseases 58, no. 2 (1999): 90–95. http://dx.doi.org/10.1136/ard.58.2.90.

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Gandaeva, Leyla A., and Elena N. Basargina. "Hypertrophic cardiomyopathy in the structure of infiltrative diseases in children." Russian Pediatric Journal 26, no. 3 (2023): 152–58. http://dx.doi.org/10.46563/1560-9561-2023-26-3-152-158.

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Introduction. In 2006, the American Heart Association identified two main groups of cardiomyopathies (CM) as primary and secondary, referring to the primary CM heart diseases of genetic, acquired or mixed etiology, and to the secondary — pathological involvement of the myocardium as a part of a systemic pathology. Aim: to determine the most common phenocopies of hypertrophic CM (HCM) in children, due to the accumulation of pathological substances in the myocardium and present their differences. Materials and methods. Instrumental diagnostic methods (echocardiography, electrocardiog

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Voznesensky, N. K., and B. T. Velichkovsky. "Aerosols of low cytotoxic metal oxide condensates as an etiological factor of occupational cardiomyopathy." PULMONOLOGIYA, no. 4 (August 28, 2008): 47–51. http://dx.doi.org/10.18093/0869-0189-2008-0-4-47-51.

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Smelters working with aluminum and brass-bronze alloys and electric welders working with carbide and low-alloyed steel develop primary myocardial injury independent on hypertension and coronary atherosclerosis. This injury is characterized by structural disorders such as myocardial concentric and eccentric hypertrophy, concentric remodeling left heart myocardium, non-coronarogenic pain, changes of T-wave in ECG, and cardiac arrhythmias. According to the 10th International classification of diseases, such signs should be considered as cardiomyopathy caused by environmental exposure, namely by f

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Boytsov, Sergey A., Sergei I. Provatorov, Irina I. Shestova, and Natalia N. Nikulina. "Emergency measures in the diagnosis and treatment of chronic forms of ischemic heart disease." Terapevticheskii arkhiv 97, no. 1 (2025): 5–10. https://doi.org/10.26442/00403660.2025.01.203125.

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Coronary heart disease (CHD) is one of the most common cardiovascular diseases and the most common cause of death in Russia. Primary diagnostics of CHD involves assessing the pre-test probability of CHD. Thereafter, myocardial ischemia should be verified by visualization technique: stress echocardiography or stress single-photon emission computed tomography of the myocardium. Myocardial revascularization improves the prognosis in patients with stable CHD who have three-vessel coronary disease or significant stenosis of the left main coronary artery. Outpatient monitoring and free provision of

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Suzuki, Ryohei, Yunosuke Yuchi, Haruka Kanno, Takahiro Teshima, Hirotaka Matsumoto, and Hidekazu Koyama. "Left and Right Myocardial Functionality Assessed by Two-Dimensional Speckle-Tracking Echocardiography in Cats with Restrictive Cardiomyopathy." Animals 11, no. 6 (2021): 1578. http://dx.doi.org/10.3390/ani11061578.

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The endomyocardial form of restrictive cardiomyopathy (EMF-RCM), a primary disorder of the myocardium, is one of the diseases with poor prognosis in cats. We hypothesized that both the left and right myocardial functional abnormalities may occur in cats with EMF-RCM, causing this disease pathophysiology and clinical status. Out of the 25 animals included in this study, 10 were client-owned cats with EMF-RCM, and 15 were healthy cats. In this study, cats were assessed for layer-specific myocardial function (whole, endocardial, and epicardial) in the left ventricular longitudinal and circumferen

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Petramala, Luigi, Antonio Concistrè, Federica Olmati, et al. "Cardiomyopathies and Adrenal Diseases." International Journal of Molecular Sciences 21, no. 14 (2020): 5047. http://dx.doi.org/10.3390/ijms21145047.

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Cardiomyopathies are myocardial disorders in which heart muscle is structurally and/or functionally abnormal. Previously, structural cardiomyocyte disorders due to adrenal diseases, such as hyperaldosteronism, hypercortisolism, and hypercatecholaminism, were misunderstood, and endomyocardial biopsy (EMB) was not performed because was considered dangerous and too invasive. Recent data confirm that, if performed in experienced centers, EMB is a safe technique and gives precious information about physiopathological processes implied in clinical abnormalities in patients with different systemic di

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Wu, Mingyue, Zixia Huang, Lijin Zeng, Chunfei Wang, and Deming Wang. "Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy." Cardiology Research and Practice 2022 (May 11, 2022): 1–10. http://dx.doi.org/10.1155/2022/6558060.

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Cardiovascular disease, especially coronary artery disease and stroke, kills around one-third of the world’s population, and myocardial infarction, a primary symptom of coronary heart disease, is a major worldwide health problem. Cardiovascular disease research has historically focused on promoting angiogenesis following myocardial damage. Myocardial vascular repair is crucial for improving myocardial infarction prognosis. Endothelial cells, the largest population of nonmyocytes within myocardial tissue, play an important role in angiogenesis. In recent years, different types of programmed cel

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Ajah O., Omodamiro O. D., and Christian E. Odo. "Medicinal Plants with Cardioprotective Potency and Some Possible Cardiac Biomarkers for Monitoring and Diagnosing Myocardial Infarction: A Review." International Journal of Research in Pharmaceutical Sciences 12, no. 4 (2021): 2454–59. http://dx.doi.org/10.26452/ijrps.v12i4.4888.

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Following the increasing rate of Cardiovascular diseases, actions have been taken and geared towards the discovery of new leads (drugs) since the existing drugs treat and manage some of these Cardiovascular ailments but with proven adverse effects on the side of the patients. Coronary artery disease which is also called Ischemic heart disease is a crucial problem worldwide, and it's known as a major non-transmissible disease. A good example of ischemic heart disease is acute myocardial infarction (MI), and its manifest due to inequality between coronary blood supply and myocardial demand. Sust

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Makarov, Igor, Daria Voronkina, Alexander Gurshchenkov, et al. "Are Endomyocardial Ventricular Biopsies Useful for Assessing Myocardial Fibrosis?" Journal of Clinical Medicine 13, no. 11 (2024): 3275. http://dx.doi.org/10.3390/jcm13113275.

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Myocardial fibrosis is an important factor in the progression of cardiovascular diseases. However, there is still no universal lifetime method of myocardial fibrosis assessment that has a high prognostic significance. The aim of the study was to determine the significance of ventricular endomyocardial biopsies for the assessment of myocardial fibrosis and to identify the severity of myocardial fibrosis in different cardiovascular diseases. Material and Methods: Endomyocardial biopsies (EMBs) of 20 patients with chronic lymphocytic myocarditis (CM), endomyocardial fragments obtained during sept

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Lee, Kijeong, Woohyun Park, Kwon-Duk Seo, and Hyeongsoo Kim. "Which one to do first?: a case report of simultaneous acute ischemic stroke and myocardial infarction." Journal of Neurocritical Care 14, no. 2 (2021): 109–12. http://dx.doi.org/10.18700/jnc.210030.

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Background: Although there are common risk factors for acute ischemic stroke and myocardial infarction, simultaneous onset of both diseases is uncommon. Here, we present a case of acute cerebral infarction with concurrent fatal myocardial infarction. Case Report: A 54-year-old man presented with left hemiparesis, gaze preponderance to the right side, and visual and tactile extinction. Computed tomography angiography showed occlusion of the right middle cerebral artery. ST-elevation myocardial infarction was suspected on electrocardiography. After the injection of intravenous tissue plasminogen

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Bergounioux, Jean, Mathieu Coureuil, Emre Belli, et al. "Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia." Infection and Immunity 84, no. 10 (2016): 3017–23. http://dx.doi.org/10.1128/iai.00420-16.

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Meningococcal septic shock is associated with profound vasoplegia, early and severe myocardial dysfunction, and extended skin necrosis responsible for a specific clinical entity designated purpura fulminans (PF). PF represents 90% of fatal meningococcal infections. One characteristic of meningococcal PF is the myocardial dysfunction that occurs in the early phase of sepsis. Furthermore, hemodynamic studies have shown that the prognosis of meningococcal sepsis is directly related to the degree of impairment of cardiac contractility during the initial phase of the disease. To gain insight into a

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Coropceanu, I., and L. Grib. "SYMPTOMS OF PATIENTS IN THE FIRST HOURS AFTER THE ONSET OF ACUTE CORONARY SYNDROME." Deutsche internationale Zeitschrift für zeitgenössische Wissenschaft 51 (March 3, 2023): 35–38. https://doi.org/10.5281/zenodo.7696545.

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The study involves the evaluation and determination of patient's symptoms that appear in the first hours after the onset of acute coronary syndrome with the aim of raising the level of health culture that is the basis of the primary prevention of cardiovascular diseases. The research was conducted on a group of 100 patients diagnosed with acute myocardial infarction with ST-segment elevation, acute myocardial infarction without ST-segment elevation and unstable angina pectoris.

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Moeswir, Dede, Fadhil Muhammad, and Putri Nurbaeti. "High Risk Primary Percutaneous Coronary Intervention (Pci) in Patient with Acute Stemi Anterior, Chronic Kidney Disease, and Confirmed Covid-19." Avicenna Medical Journal 2, no. 2 (2022): 27–32. http://dx.doi.org/10.15408/avicenna.v2i2.23931.

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Background: An acute ST-elevation myocardial infarction (STEMI) anterior occurs due to occlusion of left anterior descending artery (LAD) branch of left coronary artery. The occlusion causing transmural myocardial ischemia which in turn to myocardial infarction due to myocardial injury or necrosis. Not only Primary Percutaneous Coronary Intervention (PCI) should be performed in STEMI less than 120 minutes as the risk of the adverse events would increase if exceeding the total ischemic time, but also the procedure can be high risk in patients with multiple clinical factors or comorbidities whic

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Abdrakhmanova, Saniya, Kuralai Zhangazieva, Nurlygul Tuyakova, Ramilya Potapova, and Saniya Saussakova. "Review on Genetic Testing of Persons for Myocardial Infarction in Practice: International Experience." Astana Medical Journal 1, no. 120 (2024): 62–68. http://dx.doi.org/10.54500/2790-1203-2024-1-120-62-68.

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In Kazakhstan, the main burden in the structure of the incidence of diseases of the circulatory system is made by myocardial infarction, the overall incidence of which tends to increase (from 71.9‰ in 2016 to 127.6‰ in 2020). Therefore, according to the national health project of the Republic of Kazakhstan, reducing mortality from diseases of the circulatory system in Kazakhstan is one of the main vectors of the national health policy. The article presents a literature review of scientific publications on genetic testing for predisposition to myocardial infarction in a number of countries, suc

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Vicente, Miguel, Roger Dopico, Luís Domingos, et al. "Primary angioplasty in acute myocardial infarction: initial experience in a developing country." Journal of Transcatheter Interventions 29 (November 17, 2021): 1–6. http://dx.doi.org/10.31160/jotci202129a202105.

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Background: Coronary artery disease is a major public health concern worldwide. In Africa, varying rates of progression increased in different countries. In Angola, although the epidemiological scenario is dominated by infectious diseases, the prevalence of coronary artery disease is increasing with notable impacts, requiring the creation of mechanisms to face this reality in a country where lack of specific infrastructure is still a challenge. The objective of this study was to describe the experience of primary angioplasty in patients with acute myocardial infarction in an Angolan tertiary c

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Plotnikova, Maria O., Irina A. Snimshchikova, Valerii I. Vishnevskij, Igor A. Saraev, Ekaterina V. Mityaeva, and Olga A. Konokotina. "Primary Prevention of Coronary Heart Disease: Issues of Concern." Актуальные проблемы медицины 47, no. 2 (2024): 171–81. http://dx.doi.org/10.52575/2687-0940-2024-47-2-171-181.

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In the Russian Federation, cardiovascular diseases are one of the leading causes of both morbidity and mortality and high economic costs of healthcare. Early identification of risk factors for cardiovascular diseases and their primary prevention underlie the ongoing process to reduce these indicators. The purpose of this work was to conduct a clinical and epidemiological study to analyze the prevalence of risk factors for cardiovascular diseases in young and middle-aged people living in the Oryol region. Materials and methods: The prospective study included 353 young and middle-aged patients w

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Yalcin, Ahmet Arif, Ismail Biyik, Faruk Akturk, et al. "Association between Endothelial Nitric Oxide Synthase Gene Polymorphism (Glu298Asp) and Coronary No-Reflow Phenomenon in Acute Myocardial Infarction." Postępy Higieny i Medycyny Doświadczalnej 73 (October 10, 2019): 529–35. http://dx.doi.org/10.5604/01.3001.0013.5253.

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No-reflow phenomenon is an important complication of primary percutaneous coronary intervention. Several variants in the endothelial nitric oxide synthase gene, which reduce endothelial nitric oxide synthase activity, are a risk factor for coronary heart disease. However, its role in no-reflow phenomenon has not yet been revealed. This study aimed to investigate whether there is a relationship between endothelial nitric oxide synthase Glu298Asp gene variant and the development of coronary no-reflow phenomenon in patients with ST elevation myocardial infarction. The study was conducted among 11

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Simpson, Kerry E., Danièlle A. Gunn-Moore, Darren J. Shaw, et al. "Pulsed-wave Doppler tissue imaging velocities in normal geriatric cats and geriatric cats with primary or systemic diseases linked to specific cardiomyopathies in humans, and the influence of age and heart rate upon these velocities." Journal of Feline Medicine and Surgery 11, no. 4 (2009): 293–304. http://dx.doi.org/10.1016/j.jfms.2008.08.003.

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Pulsed-wave Doppler tissue imaging (pw-DTI) techniques allow the non-invasive assessment of myocardial dynamics. pw-DTI has demonstrated regional and global diastolic impairment in various forms of human and feline cardiomyopathy. We hypothesise that in geriatric cats with systemic diseases that have been linked to specific cardiomyopathies in human beings, the myocardial velocity profile will be altered when compared to either normal or hypertrophic cardiomyopathy (HCM) cats; and that both age and heart rate have a significant affect upon pw-DTI velocities. The aims of this study were to dete

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More, Sagar A., Rucha S. Deore, Harshal D. Pawar, et al. "CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies." International Journal of Molecular Sciences 25, no. 3 (2024): 1683. http://dx.doi.org/10.3390/ijms25031683.

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The lipid endocannabinoid system has recently emerged as a novel therapeutic target for several inflammatory and tissue-damaging diseases, including those affecting the cardiovascular system. The primary targets of cannabinoids are cannabinoid type 1 (CB1) and 2 (CB2) receptors. The CB2 receptor is expressed in the cardiomyocytes. While the pathological changes in the myocardium upregulate the CB2 receptor, genetic deletion of the receptor aggravates the changes. The CB2 receptor plays a crucial role in attenuating the advancement of myocardial infarction (MI)-associated pathological changes i

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Markabayeva, Akbayan, Aiman Kerimkulova, Riza Nurpeissova, Ainur Ospanova, and Yerkezhan Zekenova. "PREVALENCE OF CARDIOVASCULAR DISEASES IN KAZAKHSTAN FOR 2013-2020." Journal of Hypertension 42, Suppl 1 (2024): e162. http://dx.doi.org/10.1097/01.hjh.0001021004.41104.0b.

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Objective: The purpose of this study was to study the incidence and mortality of diseases of the circulatory system for 2013-2020 in the Republic of Kazakhstan. Design and method: A statistical analysis of morbidity and mortality rates was carried out based on the statistical collections of the Ministry of Health of the Republic of Kazakhstan -Health of the population of the Republic of Kazakhstan and the activities of healthcare organizations, the Committee on Statistics of the Ministry of National Economy of the Republic of Kazakhstan for 2013 - 2020. Results: In Kazakhstan, according to the

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Praena-Segovia, J., A. Sanchez-Gastaldo, M. Bernabeu-Wittel, R. Ocete-Pérez, R. Ávila-Polo, and M. L. Martino. "Primary Systemic Amyloidosis and High Levels of Angiotensin-Converting Enzyme: Two Case Reports." Case Reports in Cardiology 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/976379.

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Infiltrative heart diseases are caused by a heterogeneous group of disorders; amyloidosis and sarcoidosis are two frequent causes of myocardial infiltration, which differ in clinical and biological outcome and treatment issues. The presence of high levels of angiotensin-converting enzyme (ACE) in a patient with infiltrative heart disease may increase suspicion of sarcoidosis. Nevertheless, no mention about increased ACE levels in extracerebral primary systemic amyloidosis is available. We present two cases of primary systemic amyloidosis, which are cardiac involvement and elevated ACE levels.

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Ahmed, Farhana, Afzalur Rahman, Mohammad Arifur Rahman, et al. "Predictors of Short Term Outcomes of Primary Percutaneous Coronary Intervention." Bangladesh Heart Journal 33, no. 2 (2018): 112–20. http://dx.doi.org/10.3329/bhj.v33i2.39307.

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Background: Acute myocardial infarction (AMI) is one of the leading causes of death and disability all over the world. Primary percutaneous coronary intervention (PCI) is the treatment of choice for patients with acute ST segment elevation myocardial infarction (STEMI). Primary PCI is being increasingly done in our country also. But the factor influencing the outcome of primary PCI in our setting are mostly unknown. The present study was conducted to investigate factors that influencing the short term outcomes of primary PCI. Materials and methods: This prospective observational study wa

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Liu, Yong, Donghui Zhang, and Dan Yin. "Pathophysiological Effects of Various Interleukins on Primary Cell Types in Common Heart Disease." International Journal of Molecular Sciences 24, no. 7 (2023): 6497. http://dx.doi.org/10.3390/ijms24076497.

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Myocardial infarction (MI), heart failure, cardiomyopathy, myocarditis, and myocardial ischemia-reperfusion injury (I/R) are the most common heart diseases, yet there is currently no effective therapy due to their complex pathogenesis. Cardiomyocytes (CMs), fibroblasts (FBs), endothelial cells (ECs), and immune cells are the primary cell types involved in heart disorders, and, thus, targeting a specific cell type for the treatment of heart disease may be more effective. The same interleukin may have various effects on different kinds of cell types in heart disease, yet the exact role of interl

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Cunha, Kamylla Santos da, Giovana Dorneles Callegaro Higashi, Alacoque Lorenzini Erdmann, Carolina Kahl, Cintia Koerich, and Betina Hörner Schlindwein Meirelles. "Myocardial revascularization: factors intervening in the reference and counter-reference in Primary Health Care." Revista da Escola de Enfermagem da USP 50, no. 6 (2016): 965–72. http://dx.doi.org/10.1590/s0080-623420160000700013.

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Abstract OBJECTIVE Understanding the factors that influence the reference and counter-reference process of people indicated/submitted to Myocardial Revascularization surgery in the Primary Health Care scenario. METHOD A qualitative research anchored in the Grounded Theory, totaling 41 participants subdivided into three groups (patients, health professionals and managers) in the Metropolitan and West Region of Santa Catarina. RESULTS Two categories elucidate the intervening factors found, contrasting the potentialities and obstacles in (creating) the bond between people affected by cardiovascul

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Joo, Seung-Jae. "Recent progress on antiplatelet therapy." Journal of Medicine and Life Science 6, no. 2 (2009): 78–86. http://dx.doi.org/10.22730/jmls.2009.6.2.78.

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The main pathogenesis of myocardial infarction and ischemic stroke is the arterial thrombosis which develops on the surface of a ruptured atheromatous plaque or damaged endothelium. Platelets are major cellular components of arterial thrombosis, Several antiplatelet drugs. which interfere with certain steps in the activation process. are prescribed for the secondary or primary prevention of cardiovascular events. Recent clinical trials indicate that the benefits of aspirin treatment in the primary prevention vary by sex. Aspirin therapy reduced the risk of ischemic stroke in women and myocardi

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Abdel, Raouf Fahmy, Taema Khaled, Mashhour Karim, El Naggar Ayman, and Khaled Hassan. "Impact of manual thrombus extraction on improving myocardial tissue level perfusion and left ventricular remodeling in ST segment elevation myocardial infarction: a prospective comparative study." Biolife 5, no. 4 (2022): 484–92. https://doi.org/10.5281/zenodo.7389934.

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<strong>ABSTRACT</strong> Background: Despite restoration of epicardial blood flow with primary PCI, microvascular obstruction with diminished myocardial perfusion occurs in large proportion of patients. Thrombus manual-aspiration seems to be practical for resolving these issues. Objective: Evaluate the effect of the Diver TMC.E., aspiration thrombectomy catheter as an adjunct to primary PCI on myocardial perfusion and left ventricular functional recovery and remodeling. Methods: We included 40 patients [57.8±9.3 year, 31 (77.5 %) males] with acute STEMI eligible for primary PCI. Patien

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Ogunpola, Adedayo, Faisal Saeed, Shadi Basurra, Abdullah M. Albarrak, and Sultan Noman Qasem. "Machine Learning-Based Predictive Models for Detection of Cardiovascular Diseases." Diagnostics 14, no. 2 (2024): 144. http://dx.doi.org/10.3390/diagnostics14020144.

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Cardiovascular diseases present a significant global health challenge that emphasizes the critical need for developing accurate and more effective detection methods. Several studies have contributed valuable insights in this field, but it is still necessary to advance the predictive models and address the gaps in the existing detection approaches. For instance, some of the previous studies have not considered the challenge of imbalanced datasets, which can lead to biased predictions, especially when the datasets include minority classes. This study’s primary focus is the early detection of hea

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Morgan, Ann D., Kieran J. Rothnie, Krishnan Bhaskaran, Liam Smeeth, and Jennifer K. Quint. "Chronic obstructive pulmonary disease and the risk of 12 cardiovascular diseases: a population-based study using UK primary care data." Thorax 73, no. 9 (2018): 877–79. http://dx.doi.org/10.1136/thoraxjnl-2017-210865.

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Risks for cardiovascular diseases (CVDs) other than myocardial infarction and stroke in the general COPD population are not well quantified. We used a matched cohort study design and Cox regression to estimate relative risks for 12 separate CVDs in a large population-based cohort of patients with COPD over a 12-year period. Associations between COPD and individual CVDs were heterogeneous, with the highest relative risks observed for heart failure and diseases of the arterial circulation (in excess of 2.5 for those aged 64–75 years). Relative risks declined with increasing age but for most CVD

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Zheng, Robert, Kenya Kusunose, Yuichiro Okushi, et al. "Impact of cancer on short-term in-hospital mortality after primary acute myocardial infarction." Open Heart 8, no. 2 (2021): e001860. http://dx.doi.org/10.1136/openhrt-2021-001860.

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BackgroundCardiovascular diseases are the second most common cause of mortality among cancer survivors, after death from cancer. We sought to assess the impact of cancer on the short-term outcomes of acute myocardial infarction (AMI), by analysing data obtained from a large-scale database.MethodsThis study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination. We identified patients who were hospitalised for primary AMI between April 2012 and March 2017. Propensity Score (PS) was estimated

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Buleu, Florina, Elena Sirbu, Alexandru Caraba, and Simona Dragan. "Heart Involvement in Inflammatory Rheumatic Diseases: A Systematic Literature Review." Medicina 55, no. 6 (2019): 249. http://dx.doi.org/10.3390/medicina55060249.

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Introduction: Patients with inflammatory rheumatic diseases have an increased risk of developing cardiovascular manifestations. The high risk of cardiovascular pathology in these patients is not only due to traditional cardiovascular risk factors (age, gender, family history, smoking, sedentary lifestyle, cholesterol), but also to chronic inflammation and autoimmunity. Aim: In this review, we present the mechanisms of cardiovascular comorbidities associated with inflammatory rheumatic diseases, as they have recently been reported by different authors, grouped in electrical abnormalities, valvu

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Kim, Ki-Hong, Inseok Ko, Jong-Yeup Kim, and Dong-Kyu Kim. "Evaluating Aspirin’s Efficacy for Primary Prevention in Cardiovascular and Cerebrovascular Disease: Insights from a Nationwide Cohort Study." Clinics and Practice 14, no. 4 (2024): 1404–16. http://dx.doi.org/10.3390/clinpract14040113.

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The effectiveness of aspirin for the primary prevention of cerebro-cardiovascular diseases in Koreans remains unclear. Therefore, we evaluated the preventive effects of low-dose aspirin (equal or less than 100 mg) on cerebro-cardiovascular events. We conducted a retrospective cohort study using the National Sample Cohort dataset. From the 1,106,580 individuals eligible in 2004, we selected 200 individuals (47% male and 22.5% aged 65 or older) who consistently received low-dose aspirin from 2004 to 2013 for inclusion in the aspirin cohort. Participants for the control cohort, who did not use as

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Fatkin, Diane, and Robert M. Graham. "Molecular Mechanisms of Inherited Cardiomyopathies." Physiological Reviews 82, no. 4 (2002): 945–80. http://dx.doi.org/10.1152/physrev.00012.2002.

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Cardiomyopathies are diseases of heart muscle that may result from a diverse array of conditions that damage the heart and other organs and impair myocardial function, including infection, ischemia, and toxins. However, they may also occur as primary diseases restricted to striated muscle. Over the past decade, the importance of inherited gene defects in the pathogenesis of primary cardiomyopathies has been recognized, with mutations in some 18 genes having been identified as causing hypertrophic cardiomyopathy (HCM) and/or dilated cardiomyopathy (DCM). Defining the role of these genes in card

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Musa, S., L. Z. Xin, V. Govindasamy, F. W. Fuen, and Kasim N. H. Abu. "Global search for right cell type as a treatment modality for cardiovascular disease." Expert Opinion on Biological Therapy 14, no. 1 (2014): 63–73. https://doi.org/10.1517/14712598.2014.858694.

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Introduction: Acute myocardial infarction is the primary cause of heart disease-related death in the world. Reperfusion therapy is currently the backbone of treatment for acute myocardial infarction albeit with many limitations. With the emergence of stem cells as potential therapeutic agents, attempts in using them to enhance cardiac function have increased exponentially. However, it has its own disadvantages, and we postulate that the primary drawback is choosing the right cell type and solving this may significantly contribute to ambitious goal of using stem cells in the regeneration medici

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Yoshida, Nanae, Nobusada Funabashi, Masae Uehara, et al. "Differentiation of diagnosis and prognoses of non-coronary arterial primary myocardial diseases with left ventricular focal myocardial thinning evaluated by multislice computed tomography." International Journal of Cardiology 145, no. 2 (2010): 277–81. http://dx.doi.org/10.1016/j.ijcard.2009.09.554.

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Lutokhina, Yulia, Elena Zaklyazminskaya, Evgeniya Kogan, Andrei Nartov, Valeriia Nartova, and Olga Blagova. "Incidence and Impact of Myocarditis in Genetic Cardiomyopathies: Inflammation as a Potential Therapeutic Target." Genes 16, no. 1 (2025): 51. https://doi.org/10.3390/genes16010051.

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Background: Myocardial disease is an important component of the wide field of cardiovascular disease. However, the phenomenon of multiple myocardial diseases in a single patient remains understudied. Aim: To investigate the prevalence and impact of myocarditis in patients with genetic cardiomyopathies and to evaluate the outcomes of myocarditis treatment in the context of cardiomyopathies. Methods: A total of 342 patients with primary cardiomyopathies were enrolled. The study cohort included 125 patients with left ventricular non-compaction (LVNC), 100 with primary myocardial hypertrophy syndr

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Penna, Claudia, Saveria Femminò, Giuseppe Alloatti, Maria F. Brizzi, Tommaso Angelone, and Pasquale Pagliaro. "Extracellular Vesicles in Comorbidities Associated with Ischaemic Heart Disease: Focus on Sex, an Overlooked Factor." Journal of Clinical Medicine 10, no. 2 (2021): 327. http://dx.doi.org/10.3390/jcm10020327.

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Extracellular vesicles (EV) are emerging early markers of myocardial damage and key mediators of cardioprotection. Therefore, EV are becoming fascinating tools to prevent cardiovascular disease and feasible weapons to limit ischaemia/reperfusion injury. It is well known that metabolic syndrome negatively affects vascular and endothelial function, thus creating predisposition to ischemic diseases. Additionally, sex is known to significantly impact myocardial injury and cardioprotection. Therefore, actions able to reduce risk factors related to comorbidities in ischaemic diseases are required to

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Munteanu, Alice E., Cristina M. Calcan, and Irina Florescu. "Evolution of mortality rates in ST elevation myocardial infarction." Romanian Journal of Military Medicine 121, no. 1 (2018): 7–10. http://dx.doi.org/10.55453/rjmm.2018.121.1.1.

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The purpose of this paper is to provide information about mortality rate in patients undergoing primary angioplasty for STEMI. Cardiovascular diseases lead to one third of the deaths worldwide, surpassing the mortality rate produced by neoplasia, acute respiratory failure and diabetes mellitus all together. In the world, approximately 17 million die annually because of cardiovascular disease and every 5 seconds one is suffering from a myocardial infarction. In 2010, in our country was implemented a national program (RO-STEMI) to offer rapid interventional treatment for patients with STEMI, ali

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Yu, Yifan, Zhiliang Li, Yuqing Cai, Jiahui Guo, Yushuang Lin, and Jing Zhao. "Vascular Endothelial Cell-Derived Exosomal Sphingosylphosphorylcholine Attenuates Myocardial Ischemia–Reperfusion Injury through NR4A2-Mediated Mitophagy." International Journal of Molecular Sciences 25, no. 6 (2024): 3305. http://dx.doi.org/10.3390/ijms25063305.

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Cardiomyocyte survival is a critical contributing process of host adaptive responses to cardiovascular diseases (CVD). Cells of the cardiovascular endothelium have recently been reported to promote cardiomyocyte survival through exosome-loading cargos. Sphingosylphosphorylcholine (SPC), an intermediate metabolite of sphingolipids, mediates protection against myocardial infarction (MI). Nevertheless, the mechanism of SPC delivery by vascular endothelial cell (VEC)-derived exosomes (VEC-Exos) remains uncharacterized at the time of this writing. The present study utilized a mice model of ischemia

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Lozhkina, N. G., S. N. Artemenko, V. B. Barbarich, et al. "Insufficient use of statins in the primary and secondary prevention of myocardial infarction: an urgent problem in modern cardiology." Real-World Data & Evidence 5, no. 1 (2025): 41–48. https://doi.org/10.37489/2782-3784-myrwd-067.

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Relevance. Myocardial infarction (MI) remains one of the leading causes of death and disability worldwide. The high prevalence of this atherosclerosis-associated disease is undoubtedly associated with insufficient prevention of cardiovascular diseases, including due to insufficient use of statins. This article highlights the problem of evaluating the use of statins as a means of primary and secondary cardiovascular prevention using the example of myocardial infarction from a sample of patients in the Siberian region.Objective. To evaluate the frequency of statin use in patients before the onse

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Samorodskaya, I. V., E. V. Bolotova, and F. Y. Bidzhieva. "Mortality rates due to diseases of the circulatory system in Karachay-Cherkess republic in 2006 and 2014." Kazan medical journal 97, no. 4 (2016): 611–18. http://dx.doi.org/10.17750/kmj2015-611.

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Aim. To study mortality rates due to diseases of the circulatory system and certain nosological forms in Karachay-Cherkess Republic in 2006 and 2014.Methods. The data of the Russian Federation Federal State Statistics Service on the number of deaths according to a short nomenclature of causes of deaths were analyzed. The nosological structure was studied, proportion of each of the causes of death in the total number of deaths from circulatory system diseases was defined. The names of groups of short nomenclature of causes of deaths in 2006 and 2014 were compared. Non-standardized and standardi

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Li, Zhi-Ke, Qiang Zhao, Ning-Fu Li, et al. "Synchronous triple primary malignant tumours in the bladder, prostate, and lung harbouring TP53 and MEK1 mutations accompanied with severe cardiovascular diseases: A case report." Open Medicine 17, no. 1 (2022): 2046–51. http://dx.doi.org/10.1515/med-2022-0616.

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Abstract Although the incidence of multiple primary malignancies (MPMs) is increasing, synchronous triple primary malignant tumours with prostate, bladder and lung is rarely reported. Gene mutation is thought to be a reason for MPMs, and severe cardiovascular diseases may interrupt the cancer treatment. Here we reported a 64-year-old male patient with synchronous triple primary malignant tumours of the bladder urothelial carcinoma, prostate adenocarcinoma, and non-small cell lung cancer (NSCLC) with mutations in TP53 and MEK1, all the three malignancies were diagnosed within 10 days. Although

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Deng, Peng, Ling Chen, Zheng Liu, et al. "MicroRNA-150 Inhibits the Activation of Cardiac Fibroblasts by Regulating c-Myb." Cellular Physiology and Biochemistry 38, no. 6 (2016): 2103–22. http://dx.doi.org/10.1159/000445568.

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Background/Aims: Cardiac fibrosis is the primary cause of deteriorated cardiac function in various cardiovascular diseases. Numerous studies have demonstrated that microRNAs (miRNAs) are critical regulators of myocardial fibrosis. Specifically, many studies have reported that miR-150 is downregulated in cardiovascular diseases, such as acute myocardial infarction (AMI), myocardial hypertrophy and myocardial fibrosis. However, the exact role of miR-150 in these pathological processes remains unknown. Methods: We used the transverse aortic constriction (TAC) mouse model to study the role of miR-

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Hayder, T. Qaddoori, azeez Hussain Osamah, Ibrahim Allawi Bahjat, azeez Hussain Aya, Ibrahim Allawi Rafa, and hussein talib Riyam. "Antioxidant Activity and Heart Diseases." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 03, no. 07 (2023): 1432–39. https://doi.org/10.5281/zenodo.8189766.

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Cardiovascular disease (CVD), which are complex conditions with many pathophysiologic pathways, has increased oxidative stress as a possible common cause. For a cell to function normally, reactive oxygen species (ROS) and antioxidants must coexist in a delicate balance. High levels of ROS damage large cellular molecules including DNA, lipids and proteins, ultimately leading to necrosis and death, although their primary function is essential to shed light on biological processes. Oxidative stress, the leading cause of death globally in people with cardiovascular disease, has an impact on a vari

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Effendi, Nurmaya, Kenji Mishiro, Hiroshi Wakabayashi, et al. "Synthesis and evaluation of radiogallium-labeled long-chain fatty acid derivatives as myocardial metabolic imaging agents." PLOS ONE 16, no. 12 (2021): e0261226. http://dx.doi.org/10.1371/journal.pone.0261226.

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Since long-chain fatty acids work as the primary energy source for the myocardium, radiolabeled long-chain fatty acids play an important role as imaging agents to diagnose metabolic heart dysfunction and heart diseases. With the aim of developing radiogallium-labeled fatty acids, herein four fatty acid-based tracers, [67Ga]Ga-HBED-CC-PDA, [67Ga]Ga-HBED-CC-MHDA, [67Ga]Ga-DOTA-PDA, and [67Ga]Ga-DOTA-MHDA, which are [67Ga]Ga-HBED-CC and [67Ga]Ga-DOTA conjugated with pentadecanoic acid (PDA) and 3-methylhexadecanoic acid (MHDA), were synthesized, and their potential for myocardial metabolic imagin

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Аджам, А. О., and Р. А. Джасим. "Silent Myocardial Ischemia in Patients with Anterior ST Elevation Myocardial Infarction Treated by Primary Percutaneous Intervention." Кардиология в Беларуси 16, no. 1 (2024): 61–68. http://dx.doi.org/10.34883/pi.2024.16.1.005.

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Введение. Безболевая ишемия миокарда (БИМ) – это состояние, характеризующееся снижением притока богатой кислородом крови к сердцу, которое не сопровождается болью в груди или другими симптомами стенокардии, такими как одышка, тошнота и потливость. БИМ не проявляется в 20–30% случаев, и только около 5% случаев обнаруживается при раннем тредмил-тестировании. Цель. Количественно оценить распространенность факторов риска БИМ у пациентов с острым инфарктом миокарда с подъемом сегмента ST (ИМпST), подвергающихся первичному чрескожному коронарному вмешательству. Материалы и методы. В проспективное об

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Chen, Wen-Hao, You-Sheng Guo, Dong-Hui Zhang, and Huan-Ji Zhang. "Long-Term Prognosis of Suspected Myocarditis and Cardiomyopathy Associated with Viral Infection of the Myocardial Tissue: A Meta-Analysis of Cohort Studies." Cardiovascular Therapeutics 2019 (December 17, 2019): 1–10. http://dx.doi.org/10.1155/2019/9342792.

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Aim. Myocarditis and cardiomyopathy impose a substantial economic burden on society. Many studies have examined the effects of various predictors on the prognosis of these diseases, such as the left ventricular systolic function, the New York Heart Association glomerular filtration rate, the QT interval, and the presence of viruses. In the present study, we conducted a meta-analysis of cohort studies to investigate the significance of the presence of viruses in the myocardial tissue on the prognosis of these diseases. Methods. The Embase, PubMed, and Cochrane library databases were searched fo

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Dolezel, Diane, Alexander McLeod, and Larry Fulton. "Examining Predictors of Myocardial Infarction." International Journal of Environmental Research and Public Health 18, no. 21 (2021): 11284. http://dx.doi.org/10.3390/ijerph182111284.

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Cardiovascular diseases are the leading cause of death in the United States. This study analyzed predictors of myocardial infarction (MI) for those aged 35 and older based on demographic, socioeconomic, geographic, behavioral, and risk factors, as well as access to healthcare variables using the Center for Disease (CDC) Control Behavioral Risk Factor Surveillance System (BRFSS) survey for the year 2019. Multiple quasibinomial models were generated on an 80% training set hierarchically and then used to forecast the 20% test set. The final training model proved somewhat capable of prediction wit

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