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1

Niauri, D. A., S. V. Chepur, Е. N. Popov, К. P. Charitonov, and I. V. Kuznetsova. "Free radical reactions in the development of combined hyperplastic processes in female reproductive system organs." Journal of obstetrics and women's diseases 54, no. 2 (2005): 31–35. http://dx.doi.org/10.17816/jowd81797.

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Intact myometrium specimen, received from 56 women of reproductive age during surgical interventions. There were 30 women with combined hyperplastic processes in the reproductive system organs (uterine myoma, endometrium hyperplasia, adenomyosis, benign ovarian tumors, mastopathy, background cervical pathology), and in 26 cases solitary uterine myoma was found. At infrared spectrometry of the lyofilized myometrium, taken from patients with combined proliferation foci, a stable peak with wave number 3500 sm1 was found, which reflects the accumulation of molecules with oxidized OHgroups and a ch
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2

Zhai, Junyu, Silvia Vannuccini, Felice Petraglia, and Linda C. Giudice. "Adenomyosis: Mechanisms and Pathogenesis." Seminars in Reproductive Medicine 38, no. 02/03 (2020): 129–43. http://dx.doi.org/10.1055/s-0040-1716687.

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AbstractAdenomyosis is a common disorder of the uterus, and is associated with an enlarged uterus, heavy menstrual bleeding (HMB), pelvic pain, and infertility. It is characterized by endometrial epithelial cells and stromal fibroblasts abnormally found in the myometrium where they elicit hyperplasia and hypertrophy of surrounding smooth muscle cells. While both the mechanistic processes and the pathogenesis of adenomyosis are uncertain, several theories have been put forward addressing how this disease develops. These include intrinsic or induced (1) microtrauma of the endometrial–myometrial
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3

Popov, Eduard N., Alexander V. Arutyunyan, Dmitry S. Sudakov, and Yulia R. Dymarskaya. "Features of proand antioxidant systems in patients with uterine leiomyoma and its combination with adenomyosis and endometrial hyperplasia and the development of recurrence after organ-saving operations." Journal of obstetrics and women's diseases 65, no. 6 (2016): 104–8. http://dx.doi.org/10.17816/jowd656104-108.

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We assessed the incidence of uterine leiomyoma recurrence after myomectomy in cases of its isolated development and combination with other hyperplastic processes of endo- and myometrium. We showed the role of pro- and antioxidant systems’ disturbances in the recurrence of combination of leiomyoma, adenomyosis and endometrial hyperplasia. We propose indole-3-carbinol and epigallocatechin administration as preventing post-operative treatment.
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4

Yaramareddy, Swapna, Siyonu Kumari Sardena, Nom Kumar Naik Bhukya, and Tulasi Ram Naik Menavath. "Fertility sparing treatment in an infertile patient with severe adenomyosis and a uterine fibroid: a case report." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 5 (2023): 1510–12. http://dx.doi.org/10.18203/2320-1770.ijrcog20231254.

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Adenomyosis and uterine leiomyoma are benign lesions of the myometrium. Adenomyosis is a myometrial lesion characterised by the presence of ectopic endometrium with or without hyperplasia of the surrounding myometrium. Uterine fibroids, also called leiomyomas or myomas, are benign tumours that arise from the smooth muscle of the uterus. A 33-year-old nulliparous woman attended the clinic with primary infertility for 18 years. She was diagnosed with severe adenomyosis and uterine fibroids. She conceived successfully after undergoing in vitro fertilization (IVF) and a downregulated frozen embryo
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5

AG, Kedrova Genrikhovna, Levakov Aleksandrovich SA, Nechaeva Evgen'evna OE, Tazitdinov Khallilovich RH, and Chelnokova Nikolaevna NN. "ULTRASOUND CRITERIA FOR DIAGNOSIS AND MONITORING OF DRUG THERAPY OF COMBINED PROLIFERATIVE DISEASES OF THE UTERUS." Journal of Clinical Practice 5, no. 3 (2014): 25–34. http://dx.doi.org/10.17816/clinpract5325-34.

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The aim of the paper was to evaluate the diagnostic accuracy of transvaginal tenderness-guided ultrasonography in the identification of location of genital endometriosis, endometrial hyperplasia and uterine fibroids before and after treatment dienogest. It is a selective progestin for the treatment of endometriosis. Adenomyosis was diagnosed when a poorly defined area of abnormal echo-texture (decreased or increased echogenicity, heterogeneous echotexture, myometrial cysts) presented in myometrium. Typical ultrasonic changes of efficacy were: homogeneity of myometrium; clear and intense contou
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6

Farooqui, Bushra Pervez, Uzma Shabab, Qamarunissa Muhabat Khan, Waqarunisa Khan, and Jaazba Qamar. "Role of transvaginal sonography in diagnosing adenomyosis and its correlation with histopathology." Rehman Journal of Health Sciences 7, no. 1 (2025): 18–26. https://doi.org/10.52442/rjhs.v7i1.477.

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Background: Adenomyosis represents a prevalent pathological condition within the field of gynecology, characterized by the aberrant proliferation of endometrial tissue within the myometrium of the uterus. Despite the diagnostic challenges associated with adenomyosis, this investigation underscores the significance of transvaginal sonography as a primary diagnostic modality within the context of the patient's gynecological assessment. Objectives: To find the role of transvaginal sonography in diagnosing adenomyosis and its correlation with histopathology. Methods: This cross-sectional study was
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7

Pujani, Mukta, Kanika Singh, Varsha Chauhan, Aparna Khandelwal, Raina Chawla, and Rashmi Ahuja. "Xanthogranulomatous Change in a Leiomyoma: First Report of an Extremely Rare Variant/Degenerative Change." Journal of Mid-life Health 14, no. 1 (2023): 60–62. http://dx.doi.org/10.4103/jmh.jmh_158_22.

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ABSTRACT Xanthogranulomatous inflammation, a specific form of chronic inflammation, is marked by parenchymal destruction, proliferative fibrosis, and infiltration of typical foamy histiocytes admixed with hemosiderin-laden macrophages and foreign-body giant cells. Myometrial xanthomatosis, a term designated for nodular or diffuse histiocytic hyperplasia of the myometrium, has been reported in association with pregnancy-related procedures. Moreover, a 2–3-fold increase in histiocytic counts has been observed in leiomyomatous areas than in adjacent normal myometrium. The first evidence of collec
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8

Jaffer, Shabana, Oksana Shynlova, and Stephen Lye. "Mammalian Target of Rapamycin Is Activated in Association with Myometrial Proliferation during Pregnancy." Endocrinology 150, no. 10 (2009): 4672–80. http://dx.doi.org/10.1210/en.2009-0419.

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Abstract The adaptive growth of the uterus during gestation involves gradual changes in cellular phenotypes from the early proliferative to the intermediate synthetic phase of cellular hypertrophy, ending in the final contractile/labour phenotype. The mammalian target of rapamycin (mTOR) signaling pathway regulates cell growth and proliferation in many tissues. We hypothesized that mTOR was a mediator of hormone-initiated myometrial hyperplasia during gestation. The protein expression and phosphorylation levels of mTOR, its upstream regulators [insulin receptor substrate-1, phosphoinositide-3-
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9

Butler, Trent, Jonathan Paul, Nick Europe-Finner, Roger Smith, and Eng-Cheng Chan. "Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility." American Journal of Physiology-Cell Physiology 304, no. 6 (2013): C485—C504. http://dx.doi.org/10.1152/ajpcell.00161.2012.

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The degree of phosphorylation of myosin light chain 20 (MLC20) is a major determinant of force generation in smooth muscle. Myosin phosphatases (MPs) contain protein phosphatase (PP) 1 as catalytic subunits and are the major enzymes that dephosphorylate MLC20. MP regulatory targeting subunit 1 (MYPT1), the main regulatory subunit of MP in all smooth muscles, is a key convergence point of contractile and relaxatory pathways. Combinations of regulatory mechanisms, including isoform splicing, multiple phosphorylation sites, and scaffolding proteins, modulate MYPT1 activity with tissue and agonist
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10

Serteva, D., E. Poryazova, and Ts Velikova. "Endometriosis Locations and Coexistence with other Uterine Conditions in a Bulgarian Sample of Patients." American International Journal of Multidisciplinary Scientific Research 5, no. 2 (2019): 5–9. http://dx.doi.org/10.46281/aijmsr.v5i2.255.

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Endometriosis is a non-tumor, estrogen-dependent, chronic gynecological disease, which is characterized by the presence of endometrial glands and stroma outside the endometrium of the uterus. Endometriosis affects between 10% and 15% of women in reproductive age. It is often associated with chronic pelvic pain and reproductive difficulties. Endometriosis can be classified as ovarian, extra-ovarian or mixed. Adenomyosis is considered, by some authors, as a separate variant of endometriosis. It is diagnosed as the presence of ectopic benign endometrial glands and stroma in the myometrium, where
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11

Hladchuk, I. Z., N. M. Rozhkovska, V. H. Marichereda, I. S. Lomakina, I. V. Shpak, and D. M. Zhelezov. "Archimetra: imaging aspects of combined pathology of the endometrium and myometrium." REPRODUCTIVE ENDOCRINOLOGY, no. 67 (March 31, 2023): 74–78. http://dx.doi.org/10.18370/2309-4117.2023.67.74-78.

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Objectives: evaluation of changes in the endometrial-myometrial junction (EMJ) in the combined pathology of the endometrium and myometrium.Materials and methods. 50 perimenopausal women with combined pathology of the endometrium and myometrium (main group) were examined. The control group consisted of 30 practically healthy women of the same age who were examined for the male factor of infertility. All patients underwent a comprehensive examination, which included clinical and paraclinical research methods.Patients were examined using transvaginal ultrasound. The DEERS (Diseases of Endometrium
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12

Hossain, Deloar, Isabelle Meiers, Junqi Qian, Gregory T. MacLennan, and David G. Bostwick. "Prostatic Stromal Hyperplasia With Atypia: Follow-up Study of 18 Cases." Archives of Pathology & Laboratory Medicine 132, no. 11 (2008): 1729–33. http://dx.doi.org/10.5858/132.11.1729.

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Abstract Context.—Prostatic stromal hyperplasia with atypia is a rare lesion that can be mistaken for sarcoma because of the presence of atypical, bizarre, degenerative myocyte nuclei. Objective.—To determine the diagnostic criteria and clinical significance of prostatic stromal hyperplasia with atypia. Design.—Eighteen cases of prostatic stromal hyperplasia with atypia were reviewed from the consultation file of one of the authors (D.G.B.). Results.—Prostatic stromal hyperplasia with atypia consists of 1 or more ill-defined, uncircumscribed, hyperplastic stromal nodules, with variable numbers
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13

Bourdon, Mathilde, Pietro Santulli, Chloe Maignien, et al. "The “Freeze-All” Strategy Seems to Improve the Chances of Birth in Adenomyosis-Affected Women." Obstetrical & Gynecological Survey 79, no. 7 (2024): 418–19. http://dx.doi.org/10.1097/01.ogx.0001027476.10970.97.

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(Abstracted from Fertil Steril 2024;121(3)) Adenomyosis is a benign uterine disorder characterized by the presence of endometrial glands and stroma within the myometrium associated with smooth muscle hyperplasia. Its presentation is heterogeneous, involving hypermenorrhea, dysmenorrhea, and infertility, with variations in phenotype based on the location of the lesions.
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14

Strakhovetska, Yuliya. "Features of pathogeny of hyperplastic processes of uterus." Perinatology and reproductology: from research to practice 4, no. 2 (2024): 89–94. https://doi.org/10.52705/2788-6190-2024-02-14.

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The objective:establishment of role infectious to the pathogen in development of hyperplastic processes of uterus. Materials and methods. 250 women which were up-diffused on five groups were inspected. Plugging criteria are in research: presence of the combined hyperplastic processes of uterus - two and more for a disease (endometrial hyperplasia, uterine fibroids and adenomyosis), verified morphologically, fertile age (25–45 years). On the basis of clinical motion of disease, information of genital status and pathomorphological conclusion the followings groups were formed: I a group was made
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15

Strakhovetska, Yuliya. "Mikrobiologichni of feature of pathogenesis of hyperplastic processes of uterus." Perinatology and reproductology: from research to practice 4, no. 3-2 (2024): 63–68. https://doi.org/10.52705/2788-6190-2024-03.2-09.

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The objective: establishment of role infectious to the pathogen in development of hyperplastic processes of uterus. Materials and methods. 250 women which were up-diffused on five groups were inspected. Plugging criteria are in research: presence of the combined hyperplastic processes of uterus – two and more for a disease (hyperplasia of endometrium, uterine fibroids and adenomiosis), verified morphologically, of fertile age (25–45 years).On the basis of clinical motion of disease, information of genital status and pathomorphological conclusion the followings groups were formed: I a group was
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16

Kostiantynivna Orishchak, Iryna, Oksana Mykhailivna Makarchuk, Nataliia Ivanivna Henyk, Oksana Mykolaivna Ostrovska, and Halyna Myroslavivna Havryliuk. "Sonoelastography evaluation in the diagnosis of endometrial pathology combined with chronic endometritis in infertile women." Journal of Medicine and Life 15, no. 3 (2022): 397–404. http://dx.doi.org/10.25122/jml-2021-0358.

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Endometrial pathology, including hyperplastic processes in the structure of reproductive disorders, occupies one of the leading places along with inflammatory diseases of the pelvic organs, contributing to infertility in 80% of cases and irregular menstrual cycle in 40–43%. This study aims to optimize the diagnostic algorithm in patients with endometrial hyperplasia combined with chronic endometritis and determine qualitative indicators of compression sonoelastography in patients with endometrial pathology and infertility. A comprehensive clinical and laboratory examination of 90 infertile pat
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17

Kornyei, JL, X. Li, ZM Lei, and ChV Rao. "Restoration of human chorionic gonadotropin response in human myometrial smooth muscle cells by treatment with follicle-stimulating hormone (FSH): evidence for the presence of FSH receptors in human myometrium." European Journal of Endocrinology 134, no. 2 (1996): 225–31. http://dx.doi.org/10.1530/eje.0.1340225.

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Kornyei JL, Li X, Lei ZM, Rao ChV. Restoration of human chorionic gondadotropin response in human myometrial smooth muscle cells by treatment with follicle-stimulating hormone (FSH): evidence for the presence of FSH receptors in human myometrium. Eur J Endocrinol 1996;134:225–31. ISSN 0804–4643 Human myometrial smooth muscle cells contain receptors for human chorionic gonadotropin (hCG)/ luteinizing hormone (LH). Exogenous hCG and LH can cause a modest hyperplasia in myometrial smooth muscle cells in culture. This response is lost after about the third subculture of the cells. The present stud
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18

Stanoevich, I. V., E. A. Kudrina, Mariya N. Zholobova, A. V. Masyakina, and A. M. Kovaleva. "Obesity and metabolic disorders as a risk factor of endometrial hyperplasia, uterine fibroids and adenomyosis." V.F.Snegirev Archives of Obstetrics and Gynecology 3, no. 3 (2016): 149–55. http://dx.doi.org/10.18821/2313-8726-2016-3-3-149-155.

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The review deals with the role of endocrine and metabolic deteriorations in the development of overlapping clinically manifested benign hyperplastic lesion of endo- and myometrium. Hyperleptinemia is a powerful potentiating factor of endocrine diseases of the uterus. Modern correction of both endocrine and metabolic disorders is a key component of the comprehensive treatment and prevention of hyperplastic diseases of the uterus.
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19

Shynlova, Oksana, Ruth Kwong, and Stephen J. Lye. "Mechanical stretch regulates hypertrophic phenotype of the myometrium during pregnancy." REPRODUCTION 139, no. 1 (2010): 247–53. http://dx.doi.org/10.1530/rep-09-0260.

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The adaptive growth of the uterus is a critical event that involves changes in cellular phenotypes throughout pregnancy. In early pregnancy, uterine growth is due to hyperplasia of uterine smooth muscle cells (SMCs) within the myometrium; however, the major component of myometrial growth occurs after mid-gestation. This study sought to test the hypothesis that increase in myometrial growth seen during late pregnancy is due to SMC hypertrophy caused by mechanical stretch of uterine tissue by a growing fetus(es) by providing direct measurements of individual SMC size. We employed a stereological
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20

Perez-Marin, C. C., L. Molina, J. M. Dominguez, Y. Millan, and J. Martin de las Mulas. "Incidental finding of uterine adenomyosis in a bitch with reproductive disorders: a case report." Veterinární Medicína 53, No. 11 (2008): 636–40. http://dx.doi.org/10.17221/1867-vetmed.

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Uterine adenomyosis, a disease not widely addressed in dogs, is characterised by the progressive penetration of endometrial glands and stroma into the myometrium, together with smooth-muscle hyperplasia. This report describes a case of adenomyosis in an 8-year-old German Shepherd bitch with mammary tumours, concomitant with cystic ovarian disease and endometrial cystic hyperplasia. Clinical signs included presence of small nodules and enlargement of mammary glands, and bloody uterine discharge. Ultrasonography confirmed the uterine and ovarian abnormalities, while the diagnosis was later confi
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21

Satwik, Ruma, Nitisha Verma, and Vijaita Thakur. "Strategies to Improve Assisted Reproductive Technique Outcomes in Women with Adenomyosis: A Narrative Review." Journal of Human Reproductive Sciences 18, no. 2 (2025): 60–69. https://doi.org/10.4103/jhrs.jhrs_100_25.

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Adenomyosis is a complex, heterogeneous condition characterised by the development of ectopic endometrial glandular and stromal tissue within the myometrium. Surrounding it, there is reactionary fibrosis, hyperplasia and hypertrophy of the surrounding smooth muscle cells. This induces inflammatory changes in the eutopic endometrium, which alters the molecular environment at the time of implantation. Evidence from systematic reviews of observational studies has suggested a lowering of implantation and live birth rates and an increase in miscarriage rates in assisted reproductive technique (ART)
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22

Ibadova, Sh T. "Structure of Hyperplastic Processes of the Uterus in Menopausal Women According to the Results of an Echographic Study." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 4 (2022): 36–40. http://dx.doi.org/10.26693/jmbs07.04.036.

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The purpose of the study was to evaluate the results of ultrasound scanning in menopausal women with endometrial hyperplastic processes. Materials and methods. Ultrasound protocols of 67 menopausal women with uterine hyperplastic processes were analyzed. Endometrial imaging data were assessed as corresponding to focal endometrial hyperplasia in 53 (79.1%) women. Uterine fibroids in combination with endometrial hyperplasia were found in 42 (62.7%) menopausal patients. According to the transvaginal ultrasound protocols, only endometrial polyp was detected in 20.9% of women (n=14). Results and di
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23

Chermak, Ihor I., Volodymyr I. Chermak, Roman M. Zakordonets, Olori Sharon Oboghene, and Anatolii Ya Senchuk. "New approaches to the treatment of endometrial pathology in patients with extragenital diseases." Biomedical update, no. 2 (November 24, 2021): 22–27. http://dx.doi.org/10.52739/bio-up.2.2021.22-27.

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With purpose to increase efficiency and decrease frequencies of complications after treatment of endo- and myometrium pathology in patients of the perimenopausal period with extragenital pathology this study has been conducted. Different conducted clinic-laboratory, instrumental and pathology examination were performed. 130 patients of the perimenopausal period from somatic pathology (46-60 years) were divided into representative groups. The main group consisted of 100 patients who suffered from endometrium hyperplasia and adenomyosis. The control group included 30 healthy women without pathol
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24

Cramer, Stewart F., and Debra S. Heller. "A Review and Reconsideration of Nonneoplastic Myometrial Pathology." International Journal of Surgical Pathology 26, no. 2 (2017): 104–19. http://dx.doi.org/10.1177/1066896917748194.

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From 1861 to 1962, clinicopathologic research tried to explain the association of abnormal uterine bleeding with uterine enlargement. The etiology was theorized as metropathy, suggesting that myometrial dysfunction may predispose to abnormal uterine bleeding. Research reached a nadir in 1962, when a major review dismissed myometrial hypertrophy as a plausible explanation after prior rejections of the theories of chronic myometritis, fibrosis uteri, and subinvolution as causes of bleeding. Subsequent to this arose a crusade against unnecessary hysterectomies in the 1970s. Although myometrial hy
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25

Mielikhova, T. V., O. V. Gryshchenko, V. V. Lazurenko, R. A. Safonov, and O. S. Alekseeva. "Optimization of diagnostic studies in patients with adenomiosis and/or hyperplastic processes of endometrium." Reproductive Endocrinology, no. 58 (May 27, 2021): 34–39. http://dx.doi.org/10.18370/2309-4117.2021.58.34-39.

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Study objective: to optimize diagnostic measures in patients with adenomyosis and/or hyperplastic endometrial processes (HEP).Material and methods. The study included 128 patients aged from 27 to 53 years. The first group included 38 (29.6%) patients with a grade I–II adenomyosis, the second group included 41 (32.1%) patients with a combination of grade I–II adenomyosis and HEP and/or uterine leiomyoma, the third group included 39 (30.5%) women with only HEP, the fourth (control) group included 10 (7,8%) women without endometrial pathology. Patients underwent hysteroscopy with targeted biopsy,
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Yazlik, Murat Onur, Arda Selin Tunc, Hatice Esra Colakoglu, et al. "Effects of Ovarian Pathologies and Uterine Inflammations on Adenomyosis in Bitches." Acta Scientiae Veterinariae 46 (August 8, 2018): 7. http://dx.doi.org/10.22456/1679-9216.87473.

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Background: Adenomyosis is a non-neoplastic condition, characterized by the presence of endometrial glands or cells in the myometrium. Adenomyosis is defined by post-operative microscopic examination of uterine tissue and a rarely seen infertility problem in bitches. The process of transformation of healthy uterus into adenomiotic uterus is still a mystery. We aimed to determine role of ovarian pathologies and uterine inflammations on pathogenesis of uterine adenomyosis in bitches.Cases: After ovariohysterectomy, the uteri were fixed and processed by routine methods. Sections were stained with
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Ramesh, B., Rachana Ghanti, and Veena Devadiga. "Multiple myometrial cysts micmicking multiple fibroid uterus." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 6 (2017): 2651. http://dx.doi.org/10.18203/2320-1770.ijrcog20172374.

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Adenomyosis is the presence of endometrial glands and stroma in the context of the myometrium, with adjacent smooth muscle hyperplasia. It may be diffuse or cystic. Adenomyotic cysts of the uterus are extremely rare. A 31 years old nulligravida woman presented to our OPD with complaints of severe dysmenorrhea and back pain since 8 months. Transvaginal ultrasound revealed retroverted uterus with diffuse adenomyosis with intramyometrial endometriotic cysts in both cornual areas, both adnexa showing multiple small endometriotic cysts. On Laparoscopy – cystic masses around 5x4cm was found near the
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Chernukha, G. E., I. A. Ivanov, Z. N. Efendieva, M. R. Dumanovskaya, and A. V. Asaturova. "Etiological structure and diagnosis of abnormal uterine bleeding." Gynecology 20, no. 2 (2018): 14–17. http://dx.doi.org/10.26442/2079-5696_2018.2.14-18.

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Abnormal uterine bleeding (AUB) is one of the most common indications for hysteroscopy. Most of the AUB cases occur due to endometrial or myometrium pathology. Among it, endometrial polyps (EP) and chronic endometritis (CE) prevalent in reproductive age, while endometrial hyperplasia (EH) and EP dominate in perimenopause. It was determined that EP and CE are characterized with menorrhagia and metrorrhagia approximately equally, whereas EH reveals AUB with oligomenorrhoea. Verification of exact endometrial pathology by ultrasound examination is hindered, that results in deviations of ultrasound
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Naghem Farouk Abed, Mona Ali Ghoshim, Ali M. Fahmi, Wisam AY Al-Obaidy, Myat Moe Thwe Aung, and Tarik Ibrahem Ali. "ADENOMYOSIS: PREVALENCE IN HYSTERECTOMY SPECIMENS WITH CLINICAL REVIEW." Malaysian Journal of Public Health Medicine 23, no. 1 (2023): 140–45. https://doi.org/10.37268/mjphm/vol.23/no.1/art.1547.

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Adenomyosis is the existence of ectopic endometrial glands and stroma within the myometrium with myometrial hypertrophy and hyperplasia. The aims of the study are, first, to determine the prevalence of adenomyosis among hysterectomy specimens. Second, to assess the clinical presentation of those patients and other pathologies coexistent in the same uterus. This is a cross-sectional study which was conducted among women, who underwent hysterectomy for various indications in a referral governmental hospital in Sana'a-Yemen. The diagnosis of adenomyosis was confirmed by postoperative histopatholo
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Doğan-Ekici, A. Işın, Alp Usubütün, Türkan Küçükali, and Ali Ayhan. "Xanthogranulomatous Endometritis: A Challenging Imitator of Endometrial Carcinoma." Infectious Diseases in Obstetrics and Gynecology 2007 (2007): 1–3. http://dx.doi.org/10.1155/2007/34763.

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Xanthogranulomatous inflammation is a distinguished histopathological entity affecting several organs, predominantly the kidney and gallbladder. So far, only a small number of cases of xanthogranulomatous inflammation occurring in female genital tract have been described, most frequently affecting the endometrium and histologically characterized by replacement of endometrium by xanthogranulomatous inflammation composed of abundant foamy histiocytes, siderophages, giant cells, fibrosis, calcification and accompanying polymorphonuclear leucocytes, plasma cells and lymphocytes of polyclonal origi
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Zafalon-Silva, Bruna, Eduarda Felini, Letícia Helena Grendene Zanardo, et al. "Adenomyosis in a domestic feline: a case report." Acta Veterinaria Brasilica 17, no. 4 (2023): 1–5. http://dx.doi.org/10.21708/avb.2023.17.4.11867.

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Adenomyosis is a non-neoplastic condition which affects the female reproductive system. This condition is rare in domestic animals, and is characterized by the invasion and abnormal growth of the endometrium into the uterine muscle region. Herein, we describe the histopathological findings of uterine adenomyosis with delayed diagnosis in a three-year-old domestic female cat, of undefined breed, with a history of periodic administration of exogenous progestagens. The cat underwent ovariohysterectomy, during which macroscopic incidental changes of increased volume in the left uterine horn were o
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Dobrokhotova, Y. E., M. R. Narimanova, L. V. Saprykina, I. Yu Ilina, and M. L. Mazo. "Mammary gland condition in premenopausal women with endometrial hyperplasia." Meditsinskiy sovet = Medical Council, no. 3 (April 15, 2021): 120–27. http://dx.doi.org/10.21518/2079-701x-2021-3-120-127.

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Introduction. Amidst a steady increase in hyperplastic processes in uterus and mammary glands, numerous studies have shown that women with dyshormonal pathology of mammary glands had a range of gynecological diseases: external or internal endometriosis, hyperplastic processes of the endometrium and myometrium, polyps, polycystic ovary syndrome (PCOS), etc.Objective. To assess the mammary gland condition in premenopausal women with endometrial hyperplasia during indole-3-car-binol (I3C) therapy.Materials and methods. A total of 42 premenopausal patients aged 45-52 years (48.54 ± 1.83) were enro
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Basha, Amira, Manal M. Abdallah, Shahinaz Elshourbagy, and Mohamed Elnamoury. "Correlation between ultrasound features and histopathological finding in cases of adenomyosis: a cross-sectional study." Tanta Medical Journal 52, no. 4 (2024): 368–73. http://dx.doi.org/10.4103/tmj.tmj_20_24.

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Background Adenomyosis is a gynecological disorder characterized by hypertrophy and hyperplasia of the surrounding myometrium and the presence of ectopic endometrial glands and stroma inside the myometrium. Aims To compare the accuracy of preoperative ultrasound (US) features with the histopathological results for the diagnosis of adenomyosis, and to determine its sensitivity for diagnosis. Patients and methods A total of 100 perimenopausal and postmenopausal patients (aged 40 to 60 years old) presented with abnormal uterine bleeding. Every patient underwent a thorough history taking, general
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Bawankar, Ruchita, Neetu Singh, and Shikha Paliwal. "Role of hysteroscopy and transvaginal sonography and its correlation with histopathological examination in perimenopausal abnormal uterine bleeding." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 4 (2023): 1106–11. http://dx.doi.org/10.18203/2320-1770.ijrcog20230822.

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Background: Abnormal uterine bleeding is any abnormal uterine bleeding outside normal volume, duration, regularity or frequency. Transvaginal sonography allows detailed assessment of anatomical abnormalities of the uterus and endometrium pathologies of the myometrium. Visual assessment can be done by hysteroscopy and cellular assessment by histopathology. Methods: This descriptive prospective cross-sectional study was conducted in Rama medical college hospital & research centre, Kanpur. 103 Perimenopausal women of 40-45 years of age with AUB attending gynecology OPD of RMCH were included.
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T.V., Mielikhova, Gryshchenko O.V., Lazurenko V.V., Safonov R.A., and Alekseeva O.S. "Optimization of diagnostic studies in patients with adenomiosis and/or hyperplastic processes of endometrium." REPRODUCTIVE ENDOCRINOLOGY, no. 58 (May 27, 2021): 34–39. https://doi.org/10.18370/2309-4117.2021.58.34-39.

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<strong>Study objective:</strong>&nbsp;to optimize diagnostic measures in patients with adenomyosis and/or hyperplastic endometrial processes (HEP). <strong>Material and methods.</strong>&nbsp;The study included 128 patients aged from 27 to 53 years. The first group included 38 (29.6%) patients with a grade I&ndash;II adenomyosis, the second group included 41 (32.1%) patients with a combination of grade I&ndash;II adenomyosis and HEP and/or uterine leiomyoma, the third group included 39 (30.5%) women with only HEP, the fourth (control) group included 10 (7,8%) women without endometrial patholo
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Du, Xiaoxin, Zhihui Cai, and Liwei Yan. "Current Status of the Diagnosis and Treatment of Adenomyosis." International Journal of General Practice Nursing 2, no. 2 (2024): 20–26. http://dx.doi.org/10.26689/ijgpn.v2i2.7249.

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Adenomyosis refers to the endometrial glands and mesenchyme that invade the myometrium through the basal layer, and under the action of hormones, repeated bleeding, myofibrous connective tissue hyperplasia formed by diffuse or limited lesions. It is a common disease in women of childbearing age and is more common in women over 40 years of age with menstruation. In recent years, the age of onset of the disease tends to be younger, which may be related to the various uterine surgical operations in clinical work, such as abortion, childbirth, curettage, chronic endometritis, and so on. The mechan
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Flaksenberg, M. A. "Morphological features of endo- and myometrium in patients with uterine leiomyoma and infertility." HEALTH OF WOMAN, no. 5-6(151-152) (July 30, 2020): 33–37. http://dx.doi.org/10.15574/hw.2020.151-152.33.

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The objective: determination of morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility to restore reproductive function and prevent recurrence of the underlying disease. Materials and methods. In order to restore reproductive function and prevent recurrence of the underlying disease, morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility were determined. Thirty samples of leiomyomatous nodes and endometrium were examined, among which 15 were obtained from women with multiple uterine le
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Khan, Khaleque N., Akira Fujishita, and Taisuke Mori. "Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility." Journal of Clinical Medicine 11, no. 14 (2022): 4057. http://dx.doi.org/10.3390/jcm11144057.

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The aim of this review article was to summarize our current understanding on the etiologies and pathogenesis of human adenomyosis and to clarify the relative association between adenomyosis and infertility. The exact pathogenesis of adenomyosis is still elusive. Among different reported concepts, direction invagination of gland cells from the basalis endometrium deep into myometrium is the most widely accepted opinion on the development of adenomyosis. According to this concept, endometrial epithelial cells and changed fibroblasts, abnormally found in the myometrium in response to repeated tis
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Benagiano, Giuseppe, Ivo Brosens, and Sabina Carrara. "Adenomyosis: New Knowledge is Generating New Treatment Strategies." Women's Health 5, no. 3 (2009): 297–311. http://dx.doi.org/10.2217/whe.09.7.

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In the early days, all mucosal invasions of abdominal organs were considered to be one pathological condition of uncertain origin, termed adenomyoma. It was only in the 1920s that endometriosis and adenomyosis were clearly separated and it took approximately 80 years to put forward a new theory reunifying their pathogenesis. Today, identification of adenomyosis is carried out exclusively through vaginal ultrasonography and MRI. These techniques have made a careful evaluation of a distinct anatomical structure and the inner myometrial layers underlying the endometrium, termed the junctional zon
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Marino, Gabriele, Cecilia Vullo, Stefania Di Giorgio, Antonina Zanghì, Giuseppe Catone, and Alessandra Sfacteria. "Hyperplastic and atrophic changes in the genital tract of a female cat following repeated treatment with deslorelin acetate – a case report." Acta Veterinaria Brno 90, no. 2 (2021): 207–10. http://dx.doi.org/10.2754/avb202190020207.

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This study aimed to investigate the morphological patterns of the genital tract after long-term treatment of deslorelin acetate in a female cat, a gonadotropin-releasing hormone agonist currently used in adult cats to obtain transient oestrus suppression. A 1-year-old Chartreux female cat was treated with 4.7 mg deslorelin acetate to suppress oestrus manifestations. The treatment was repeated for a total of × 3 every 2 years. After 8 years, the female cat came into oestrus again, but she was no more implanted, and an ovariohysterectomy was performed. Before surgery, an ultrasound examination w
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Rashid, Aisha, Haniya Qamar, and Saba Pario. "Frequency and morphology of benign histopathological lesions in total abdominal hysterectomy specimens." Professional Medical Journal 27, no. 03 (2020): 481–86. http://dx.doi.org/10.29309/tpmj/2020.27.03.3156.

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Hysterectomy is one of the most frequently performed gynecological procedure all over the globe undertaken for varying indications, to effectively cure many gynaecological conditions. Histopathological analysis of the hysterectomy specimens should be undertaken for justification of procedure and diagnostic purposes. Objectives: To determine the frequency and morphology of different benign histopathological lesions in total abdominal hysterectomy specimens. Study Design: Descriptive cross-sectional study. Setting: Department of Pathology Fatima Jinnah Medical College. Period: From Jan 2015 to J
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Sulima, Anna N., Inna O. Kolesnikova, Aleksandra A. Davydova, and Maxim A. Kriventsov. "Hysteroscopic and morphological assessment of intrauterine pathology in different age periods." Journal of obstetrics and women's diseases 69, no. 2 (2020): 51–58. http://dx.doi.org/10.17816/jowd69251-58.

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The pathology of the endo- and myometrium takes the main place in the structure of gynecological diseases. The introduction of endoscopic technologies has expanded the diagnostic capabilities of the study of intrauterine pathology. The morphological method is the gold standard in diagnosing the uterine cavity pathology. A retrospective analysis of 100 video protocols of hysteroscopy and morphological data obtained in Vash Doctor Clinic Ltd., Simferopol over the year 2018 was performed. During a retrospective analysis of hysteroscopic pictures and pathomorphological findings, all patients were
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Douglas, A. J., E. W. Clarke, and D. F. Goldspink. "Influence of mechanical stretch on growth and protein turnover of rat uterus." American Journal of Physiology-Endocrinology and Metabolism 254, no. 5 (1988): E543—E548. http://dx.doi.org/10.1152/ajpendo.1988.254.5.e543.

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A new technique has been developed and used to distend the uterus of nonpregnant rats for up to 5 days. Continuous distension of the saline-filled uterus induced rapid and extensive growth of the whole uterus and the myometrium by a combination of hyperplasia and hypertrophy. In both cases, 1 day after this imposition of mechanical stretch significant increases (25-50%) in the protein, RNA, and DNA contents were found, with larger changes (100-250%) being progressively expressed up to 5 days. This stretch-induced growth primarily results from a stimulation of protein synthesis (measured both i
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Rushikesh, Surani, Pokar Reeti, and Patel Parita. "Clinicopathological Analysis of Hysterectomy Specimen at Tertiary Care Centre: A Retrospective Study." International Journal of Pharmaceutical and Clinical Research 16, no. 11 (2024): 186–90. https://doi.org/10.5281/zenodo.14249149.

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<strong>Background:&nbsp;</strong>female in their life prone to developed various pathological condition in hormone responsive genital tract system. This study aims to identify various pathological lesions in hysterectomy specimen along with clinical correlation.&nbsp;<strong>Materials and Methods:&nbsp;</strong>the present study was retrospective study conducted at GMERS medical college and hospital, Himmatnagar during October 2023 to September 2024. All form of hysterectomy specimens received were examined. Routine gross examination done and representative sections were taken and stained wit
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Benyuk, V. A., D. M. Altibaeva, V. N. Goncharenko, and V. V. Kurochka. "The role of immune mechanisms in the development of benign uterus pathology." HEALTH OF WOMAN, no. 5(111) (June 20, 2016): 30–32. http://dx.doi.org/10.15574/hw.2016.111.30.

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The objective: to study the role of immunological mechanisms in the development of adenomyosis with endometrial hyperplasia in women of reproductive age and the phased introduction of an integrated hormonal and immunostimulating therapy. Patients and methods. The authors investigated the effect of hormone therapy on the immune system of women with adenomyosis and endometrial hyperplasia: We evaluated the influence of hormone therapy 135 women of reproductive age with adenomyosis in combination with endometrial hyperplasia: group i - 45 women using a progestogen (6 months); II – 45 women who to
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Antovska, Vesna S., Iskra Krstevska, Milka Trajanova, et al. "Endometrioid Adenocarcinoma Arising in Adenomyoma in a Woman with a Genital Prolapse - Case Report." Open Access Macedonian Journal of Medical Sciences 6, no. 6 (2018): 1091–94. http://dx.doi.org/10.3889/oamjms.2018.239.

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BACKGROUND: Endometrial cancer is the third-ranked genital malignancy in women and includes 3% of cancer deaths. There is a 2.8% chance of a woman developing endometrial cancer during her lifetime. Low-grade endometrioid adenocarcinomas are often seen along with endometrial hyperplasia, but high-grade endometrioid adenocarcinomas have more solid sheets of less-differentiated tumour cells, which are no longer organised into glands, often associated with surrounded atrophic endometrium.CASE REPORT: We present an unusual case of endometrial adenocarcinoma arising in adenomyoma in 74-year old woma
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Menon, Santosh, Komal Kathuria, Kedar Deodhar, and Rajendra Kerkar. "Mesonephric adenocarcinoma (endometrioid type) of endocervix with diffuse mesonephric hyperplasia involving cervical wall and myometrium: An unusual case report." Indian Journal of Pathology and Microbiology 56, no. 1 (2013): 51. http://dx.doi.org/10.4103/0377-4929.116150.

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Casadio, Paolo, Mariangela La Rosa, Andrea Alletto, et al. "Fertility Sparing Treatment of Endometrial Cancer with and without Initial Infiltration of Myometrium: A Single Center Experience." Cancers 12, no. 12 (2020): 3571. http://dx.doi.org/10.3390/cancers12123571.

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Endometrial cancer (EC) is the fourth largest female cancer in Europe and North America. In 5% of cases, the diagnosis is made in women who wish to become pregnant. In our retrospective study, we reported our experience about fertility sparing treatment of G1 endometrioid endometrial cancer (G1 EEC) or atypical endometrial hyperplasia/endometrial intraepithelial neoplasm (AEH/EIN) in young women desiring pregnancy treated in our Center. Conservative treatment was based on operative hysteroscopy and hormone therapy with megestrol acetate (160 mg/die for 9 months). For the first time we included
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Tokhunts, K. A., A. D. Khudaverdyan, N. B. Abgaryan, N. A. Nahapetyan, and V. L. Manvelyan. "Combined administration of Dienogest and Levonorgestrel – Releasing Intrauterine System Mirena." NEW ARMENIAN MEDICAL JOURNAL, no. 3 (2022): 86–90. http://dx.doi.org/10.56936/18290825-2022.16.3-86.

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Objectives: Intrauterine hormone-releasing systems are now widely applied to treat metrorrhagia (polymenorrhea), endometrial hyperplasia and adenomyosis. In previous works we found that risk factors for expulsion of intrauterine device, besides the deformation of the uterine cavity, was the expansion of uterine cavity area &gt; 9 cm2, associated with increased distance between tubal angles &gt;4.5 cm and after the insertion of Levonorgestrel-releasing Intrauterine System (Mirena), among the patients with indicated parameters of uterine cavity, the expulsion reached 90%. Another widely used med
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Laguë, Marie-Noëlle, Jacqui Detmar, Marilène Paquet, et al. "Decidual PTEN expression is required for trophoblast invasion in the mouse." American Journal of Physiology-Endocrinology and Metabolism 299, no. 6 (2010): E936—E946. http://dx.doi.org/10.1152/ajpendo.00255.2010.

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Trophoblast invasion likely depends on complex cross talk between the fetal and maternal tissues and may involve the modulation of phosphatidylinositol 3-kinase (PI3K)/AKT signaling activity in maternal decidual cells. In this report, we studied implantation in Ptentm1Hwu/tm1Hwu ;Amhr2tm3(cre)Bhr/+ mice, which lack the PI3K signaling antagonist gene Pten in myometrial and stromal/decidual cells. Primiparous Ptentm1Hwu/tm1Hwu ;Amhr2tm3(cre)Bhr/+ mice were found to be subfertile because of increased fetal mortality at e11.5. Histopathological analyses revealed a failure of decidual regression in
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