Academic literature on the topic 'Myometrium macicy'

A case of spontaneous endometriosis was diagnosed in the pigtailed macaque ( Macaca nemestrina nemestrina) with the aid of high-field (2·35 T), T2-weighted (TE50), C1H2-suppressed, oblique nuclear magnetic resonance imaging (MRI). Postmortem histology was obtained. A variety of endometriotic lesions was seen with MRI, including extrauterine hyperintense apparently cystic regions, extrauterine hypointense regions apparently associated with intracellular paramagnetic iron proteins, and an enlarged myometrium exhibiting adenomyosis foci.

ABSTRACT The antiuterotrophic efficacy of the pure antioestrogen ICI 182,780 has been demonstrated previously by magnetic resonance imaging (MRI) in ovariectomized oestrogen-treated monkeys (Macaca nemestrina). Further characterization of the effects of ICI 182,780 in intact adult female monkeys with normal menstrual cycles was undertaken to provide an indication of its potential actions in premenopausal women. Changes in the volume of uterine tissues were measured by MRI in early, mid and late cycle. The volume of the uterus varied up to fivefold between individual monkeys but serial observations in individuals provided sufficient precision to allow accurate assessments to be made of changes in the endometrium and myometrium during the course of the menstrual cycle and following ICI 182,780 administration. In comparison with its initial size in untreated monkeys, the endometrium increased in volume by 60% and 125% in the mid and late cycle respectively. In contrast, the size of the myometrium decreased significantly, by 16% from early to mid cycle and then recovered to near its initial volume in the late cycle. Treatment with ICI 182,780 beginning in the early part of the menstrual cycle prevented the growth of the uterus. The magnitude and duration of the response was dependent on whether or not ovulation occurred during treatment with ICI 182,780. In animals rendered anovulatory, growth of the endometrium was blocked completely by ICI 182,780 and the volume of the tissue declined below that present at the start of the menstrual cycle. Antiuterotrophic efficacy was significantly less in monkeys which ovulated during treatment with ICI 182,780. The volume of myometrium was reduced substantially by antioestrogen treatment, and the difference in response between ovulatory and anovulatory monkeys was less marked than that of the endometrium. Journal of Endocrinology (1993) 138, 203–209

ABSTRACT ICI 182,780 is a potent specific pure antioestrogen which may offer advantages in breast cancer treatment compared with partial agonists like tamoxifen. To characterize further the potency and efficacy of ICI 182,780, its effects on the uterus of ovariectomized, oestrogen-treated monkeys (Macaca nemestrina) have been measured using magnetic resonance imaging (MRI). Quantitative MRI allows accurate non-invasive repetitive measurements of endometrial and myometrial volume following hormonal treatments, using each animal as its own control. Single i.m. injections of a long-acting oil-based formulation of ICI 182,780 sustained blockade of oestradiol action on the monkey uterus in a dose-dependent manner for 3–6 weeks. Repeated injections of 4 mg ICI 182,780/kg at 4-weekly intervals provided increasingly effective blockade of uterine proliferation. In a short-acting formulation, ICI 182,780 also completely blocked the trophic action of oestradiol, administered concurrently, in ovariectomized monkeys. Similarly, ICI 182,780 caused involution of the uterus stimulated by prior treatment with oestradiol. The rate and extent of uterine involution in monkeys treated with ICI 182,780 was similar to that seen following oestrogen withdrawal. These studies demonstrate that ICI 182,780 is a fully effective pure antioestrogen in a primate. Journal of Endocrinology (1992) 135, 239–247

Foram utilizados 15 úteros de macacos Rhesus (Macaca mulatta), sendo 5 fêmeas nulíparas, 5 primíparas e 5 pluríparas. Todas as fêmeas eram maduras sexualmente, tinham de 38 a 87 meses de idade e pesavam entre 4,9 a 7,39 Kg. Em todos os animais foram feitos o estudo topográfico, biometria dos órgãos, microscopia de luz e quantificação de colágeno no miométrio. O útero se situa na pelve, sobre a vagina, entre a bexiga urinária e o intestino reto. O útero é do tipo simples, caracterizado por um fundo globóide, localizado sobre a junção com as tubas uterinas, oco, alongado e com contorno piriforme. Pode ser dividido macroscopicamente em quatro regiões: corpo, fundo, istmo e cérvix uterina. Não foram observadas diferenças macroscópicas e de topografia entre as fêmeas nulíparas, primíparas e pluríparas. O comprimento total do útero nas fêmeas nulíparas tiveram média de 4,12 ± 0,2 cm, nas primíparas 4,32 ± 0,26 cm e nas pluríparas 5,14 ± 0,71 cm. Comparando as mensurações entre as três categorias, observou-se que as fêmeas pluríparas possuem as maiores medidas. O endométro é formado por um epitélio prismático simples e uma lâmina própria que contém as glândulas endometriais, que também possui epitélio prismático simples. Em todos os animais estudados, as glândulas endometriais eram tubulares simples e retas. Em relação à distribuição do colágeno no miométrio, o método de Picrossirius Red, permitiu observar uma ampla distribuição do colágeno por todo o compartimento. A cérvix é constituída por um epitélio prismático simples, possui poucas fibras musculares lisas e consiste principalmente em tecido conjuntivo denso. A porcentagem de colágeno encontrado no miométrio das fêmeas nulíparas teve uma média de 26,32 ± 0,82, nas primíparas 29,07 ± 1,01 e nas pluríparas 38,93 ± 1,07, pelo método de coloração de Picrosirius Red.
Fifteen uterus of rhesus macaques (Macaca mulatta) were used, collected from 5 nulliparous, 5 primaparous and 5 pluriparous individuals. All females were sexually mature, they were 38-87 months of age and weighed between 4,9 to 7,39 Kg. All animals were submitted to study topography, biometry of the organs, light microscopy and quantification of collagen in the myometrium. The uterus is located in the pelvis on the vagina between the bladder and rectum. The uterus has a simple type, characterized by a globular background, located on the junction of the fallopian tubes, hollow, elongated and pear-shaped contour. Grossly it can be divided into four parts: body, bottom, isthmus and cervix. No differences were observed macroscopic and topography between nulliparous, rimiparous and pluriparous. The total length of the uterus in nulliparous females had a mean of 4,12 ± 0,2 cm in primiparous 4,32 ± 0,26 cm and 5,14 ± 0,71 cm in pluriparous. Comparing the measurements among the three categories, it was observed that the sows have greater measures. The endometrial epithelium is formed by a simple prismatic and a lamina propria containing the endometrial glands, wich also has a simple prismatic epithelium. In all studied animals the endometrial glands were simple and straight tubular. Regarding the distribution of collagen around the bay. The cervix is composed of a simple prismatic epithelium, has a few smooth muscle fibers and consists mainly of dense connective tissue. The percentage of collagen found in the myometrium of the nulliparous females had an average of 26, 32 ± 0, 82, 29, 07 ± 1, 01 in primiparous and pluriparous 38,93 ± 1,07, through the staining method of Picrosirius Red.