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Journal articles on the topic 'Myosin-based machine'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Bianco, Pasquale, Irene Pertici, Luca Melli, et al. "Force and Power of a Synthetic Myosin II-Based Machine." Biophysical Journal 112, no. 3 (2017): 116a—117a. http://dx.doi.org/10.1016/j.bpj.2016.11.656.

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2

Matsuura, H., M. Nakano, and T. Nemoto. "3L1015 Kinetic Thoery of Molecular Machine based on Thermal Noise : Actin-Myosin and Molecular Motor." Seibutsu Butsuri 42, supplement2 (2002): S185. http://dx.doi.org/10.2142/biophys.42.s185_4.

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Pertici, Irene, Lorenzo Bongini, Luca Melli, et al. "The Power of a Synthetic Machine Based on the Fast Myosin Isoform of Skeletal Muscle." Biophysical Journal 114, no. 3 (2018): 211a. http://dx.doi.org/10.1016/j.bpj.2017.11.1181.

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4

Horowitz, R. A., C. M. Powers, P. Valero, and R. Craig. "The Three Dimensional Organization of Smooth Muscle: Information from Serial Section Reconstructions." Microscopy and Microanalysis 4, S2 (1998): 438–39. http://dx.doi.org/10.1017/s1431927600022315.

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Smooth muscle is a machine consisting of working and supporting elements whose structure and 3D organization must be elucidated for the mechanics of shortening and tension generation to be understood. Based on longitudinal and serial transverse sections of rabbit portal vein it was suggested that the contractile elements of smooth muscle formed “mini-sarcomeres”, analogous to skeletal muscle, containing parallel arrays of 3-5 myosin filaments 1.6-2.2 um long. Observations at the light microscopic level were consistent with this idea. The past decade has seen little further investigation into t

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Willison, Keith Robert. "The structure and evolution of eukaryotic chaperonin-containing TCP-1 and its mechanism that folds actin into a protein spring." Biochemical Journal 475, no. 19 (2018): 3009–34. http://dx.doi.org/10.1042/bcj20170378.

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Actin is folded to its native state in eukaryotic cytosol by the sequential allosteric mechanism of the chaperonin-containing TCP-1 (CCT). The CCT machine is a double-ring ATPase built from eight related subunits, CCT1–CCT8. Non-native actin interacts with specific subunits and is annealed slowly through sequential binding and hydrolysis of ATP around and across the ring system. CCT releases a folded but soft ATP-G-actin monomer which is trapped 80 kJ/mol uphill on the folding energy surface by its ATP-Mg2+/Ca2+ clasp. The energy landscape can be re-explored in the actin filament, F-actin, bec

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Lansing Taylor, D. "Temporal and Spatial Dynamics of the Actin-Based Cytoskeleton." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 2 (1990): 546. http://dx.doi.org/10.1017/s0424820100136337.

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There has been a renaissance and revolution in the use of light microscopy in the biomedical sciences. The renaissance has been due to the importance of studying the temporal and spatial dynamics of ions, metabolites and macromolecules in living cells and tissues. The revolution has been due to the integration of developments in molecular biology, fluorescent probe chemistry, machine vision, and imaging technology. It is now possible to use the living cell as a microcuvette and to explore the chemical and molecular dynamics responsible for cellular functions.We have been investigating the form

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Ghulam, Ali, Rahu Sikander, Dhani Bux Talpur, et al. "IDENTIFYING MOLECULAR FUNCTIONS OF DYNEIN MOTOR PROTEINS USING EXTREME GRADIENT BOOSTING ALGORITHM WITH MACHINE LEARNING." Journal of Mountain Area Research 8 (November 29, 2022): 1. http://dx.doi.org/10.53874/jmar.v8i0.166.

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The majority of cytoplasmic proteins and vesicles move actively primarily to dynein motor proteins, which are the cause of muscle contraction. Moreover, identifying how dynein are used in cells will rely on structural knowledge. Cytoskeletal motor proteins have different molecular roles and structures, and they belong to three superfamilies of dynamin, actin and myosin. Loss of function of specific molecular motor proteins can be attributed to a number of human diseases, such as Charcot-Charcot-Dystrophy and kidney disease. It is crucial to create a precise model to identify dynein motor prote

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Eggers, Britta, Karin Schork, Michael Turewicz, et al. "Advanced Fiber Type-Specific Protein Profiles Derived from Adult Murine Skeletal Muscle." Proteomes 9, no. 2 (2021): 28. http://dx.doi.org/10.3390/proteomes9020028.

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Skeletal muscle is a heterogeneous tissue consisting of blood vessels, connective tissue, and muscle fibers. The last are highly adaptive and can change their molecular composition depending on external and internal factors, such as exercise, age, and disease. Thus, examination of the skeletal muscles at the fiber type level is essential to detect potential alterations. Therefore, we established a protocol in which myosin heavy chain isoform immunolabeled muscle fibers were laser microdissected and separately investigated by mass spectrometry to develop advanced proteomic profiles of all murin

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Safari, Zohreh, Stephen C. Rogers, Mary E. Brummet, et al. "Oxygen Responsive Myosin Activation Governs Oscillatory Piezo1 Signaling in RBCs during Circulatory Transit." Blood 144, Supplement 1 (2024): 2453. https://doi.org/10.1182/blood-2024-207417.

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BACKGROUND: In mature red blood cells (RBCs), endothelial nitric oxide synthase (eNOS) migrates from cytosol to membrane in an O₂-dependent fashion (i.e., eNOS exhibits cyclic translocation/activation within RBCs during circulation). Upon RBC deoxygenation, RBC eNOS associates with the membrane and is activated, playing an important role in glycolytic metabolon disassembly and regulation of RBC energetics. We have previously demonstrated that eNOS translocation and activation is mechanistically linked to (1) deoxyHb docking on the Band 3 cytoplasmic domain (cdB3), followed by (2) Piezo1-based

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Chen, Zhongning, Tyler Fugere, and Yadav Pandey. "Expression profile of micro-RNA of lymphovascular invasive colon cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16109-e16109. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16109.

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e16109 Background: Lymphovascular invasion (LVI) is an independent predictor of disease progression in patients with colorectal cancer, and is often associated with high tumor grade and advanced tumor stage. In concordance, micro-RNA(miRNA), which are small non-coding RNA that regulate post-transcriptional gene expression, have also recently been shown to be promising biomarkers to predict disease prognosis. The purpose of this study is to investigate [1] potential mechanism of tumor invasion by identifying miRNA that are differentially expressed with respect to LVI status, and [2] create a mo

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Nelson, Anders R., Steven L. Christiansen, Kristen M. Naegle, and Jeffrey J. Saucerman. "Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts." Proceedings of the National Academy of Sciences 121, no. 5 (2024). http://dx.doi.org/10.1073/pnas.2303513121.

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Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti-fibrotic drugs differentially regulate measures of cardiac fibroblast phenotype, which may help identify treatments for cardiac fibrosis. We conducted a high-content microscopy screen of human cardiac fibroblasts treated with 13 clinically relevant drugs in the context of TGFβ and/or IL-1β, measuring phenotype across 137 single-cell features.

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Matsunaga, Yasuhiro, Sotaro Fuchigami, Tomonori Ogane, and Shoji Takada. "End-to-end differentiable blind tip reconstruction for noisy atomic force microscopy images." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-022-27057-2.

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AbstractObserving the structural dynamics of biomolecules is vital to deepening our understanding of biomolecular functions. High-speed (HS) atomic force microscopy (AFM) is a powerful method to measure biomolecular behavior at near physiological conditions. In the AFM, measured image profiles on a molecular surface are distorted by the tip shape through the interactions between the tip and molecule. Once the tip shape is known, AFM images can be approximately deconvolved to reconstruct the surface geometry of the sample molecule. Thus, knowing the correct tip shape is an important issue in th

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Lin, Yibin, Xiao Chen, Linping Lin, Benhua Xu, Xiaofeng Zhu та Xian Lin. "Sesamolin serves as an MYH14 inhibitor to sensitize endometrial cancer to chemotherapy and endocrine therapy via suppressing MYH9/GSK3β/β-catenin signaling". Cellular & Molecular Biology Letters 29, № 1 (2024). http://dx.doi.org/10.1186/s11658-024-00583-9.

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Abstract Background Endometrial cancer (EC) is one of the most common gynecological cancers. Herein, we aimed to define the role of specific myosin family members in EC because this protein family is involved in the progression of various cancers. Methods Bioinformatics analyses were performed to reveal EC patients’ prognosis-associated genes in patients with EC. Furthermore, colony formation, immunofluorescence, cell counting kit 8, wound healing, and transwell assays as well as coimmunoprecipitation, cycloheximide chase, luciferase reporter, and cellular thermal shift assays were performed t

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Kurtzeborn, Kristen, Vladislav Iaroshenko, Tomáš Zárybnický, et al. "Epithelial cell shape changes contribute to regulation of ureteric bud branching morphogenesis." FEBS Journal, June 15, 2025. https://doi.org/10.1111/febs.70156.

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Branching morphogenesis orchestrates organogenesis in many tissues, including the kidney, where ureteric bud (UB) branching determines kidney size and shape and the final nephron number. Molecular regulation of UB branching is rather well studied, whereas the cellular mechanisms and tissue organization during UB arborization are less understood. Here, we characterized epithelial cell morphology in three dimensions (3D), studied mechanisms regulating cell shape changes, and analyzed their contribution to novel branch initiation in normal and branching‐incompetent bud tips. Unbiased machine‐lear

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Jang, Yongwoo, Sung Min Kim, Eunyoung Kim, Dong Yeop Lee, Tong Mook Kang, and Seon Jeong Kim. "Biomimetic cell-actuated artificial muscle with nanofibrous bundles." Microsystems & Nanoengineering 7, no. 1 (2021). http://dx.doi.org/10.1038/s41378-021-00280-z.

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AbstractBiohybrid artificial muscle produced by integrating living muscle cells and their scaffolds with free movement in vivo is promising for advanced biomedical applications, including cell-based microrobotic systems and therapeutic drug delivery systems. Herein, we provide a biohybrid artificial muscle constructed by integrating living muscle cells and their scaffolds, inspired by bundled myofilaments in skeletal muscle. First, a bundled biohybrid artificial muscle was fabricated by the integration of skeletal muscle cells and hydrophilic polyurethane (HPU)/carbon nanotube (CNT) nanofibers

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Arif, Irfan, Ayesha Rasheed, Sadia Nazeer, and Fareeha Shahid. "Physiological and morphological impact of physical activity and nutritional interventions to offset disuse-induced skeletal muscle atrophy." European Journal of Translational Myology, April 15, 2025. https://doi.org/10.4081/ejtm.2025.13177.

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Skeletal muscle tissue acts as a functional unit for physical movements, energy metabolism, thermogenesis, and metabolic homeostasis. In this literature review, the underlying mechanisms of skeletal muscle atrophy and the prevention strategies, including vigorous training and nutritional modifications are focused. Furthermore, the comparative analysis of multiple interventions is briefly explained. Ageing is an inevitable process often associated with cognitive impairment and physical decline due to muscular atrophy. Skeletal muscle atrophy is characterized by low muscle mass due to multiple u

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17

Abraham, T., A. J. Sehnert, W. Anderson, et al. "Mavacamten induces a clinical, hemodynamic, and biomarker response beyond the primary endpoint in EXPLORER-HCM: results from a post hoc machine learning analysis." European Heart Journal 43, Supplement_2 (2022). http://dx.doi.org/10.1093/eurheartj/ehac544.1718.

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Abstract Introduction Mavacamten, a first-in-class selective inhibitor of cardiac myosin, was demonstrated in EXPLORER-HCM (NCT03470545) to be superior to placebo in achieving a primary endpoint of either (1) a ≥1.5 mL/kg/min increase in peak oxygen consumption (pVO2) and at least one New York Heart Association (NYHA) class reduction, or (2) a ≥3.0 mL/kg/min pVO2 increase without NYHA class worsening, in adults with obstructive hypertrophic cardiomyopathy (oHCM). However, the observed benefits of mavacamten were broader than the primary endpoint, suggesting a complex effect of the drug beyond

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18

Shen, Hua, Shi-Yong Dong, Ming-Shi Ren, and Rong Wang. "Ventricular arrhythmia and sudden cardiac death in hypertrophic cardiomyopathy: From bench to bedside." Frontiers in Cardiovascular Medicine 9 (August 18, 2022). http://dx.doi.org/10.3389/fcvm.2022.949294.

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Patients with hypertrophic cardiomyopathy (HCM) mostly experience minimal symptoms throughout their lifetime, and some individuals have an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). How to identify patients with a higher risk of ventricular arrythmias and SCD is the priority in HCM research. The American College of Cardiology/American Heart Association (ACC/AHA) and the European Society of Cardiology (ESC) both recommend the use of risk algorithms to identify patients at high risk of ventricular arrhythmias, to be selected for implantation of implantable cardiove

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19

Xu, Zifan, Zi Lei, Shilan Peng, et al. "Prognostic and tumor microenvironmental features of gastric cancer revealed by macrophage polarization and protein lactylation-related genes." Frontiers in Genetics 16 (July 2, 2025). https://doi.org/10.3389/fgene.2025.1541489.

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BackgroundThe progression of gastric cancer (GC) is closely linked to macrophage polarization and protein lactylation; however, its underlying mechanisms remain poorly understood. This study aimed to elucidate the molecular mechanisms of GC using transcriptomic analysis.MethodsCandidate genes were identified by intersecting differentially expressed genes with key module genes associated with protein lactylation and macrophage polarization. Protein-protein interaction analysis was performed to uncover interacting genes. Prognostic genes were determined using univariate Cox regression and machin

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20

Lopez Cruz, Carla, Elizabeth Goya-Jorge, Caroline McKinney-Aguirre, et al. "Preservation of Epithelial Barrier Integrity and Microbial Populations with Mechanical Perfusion in Intestinal Transplantation." Physiology 40, S1 (2025). https://doi.org/10.1152/physiol.2025.40.s1.1515.

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Transplantation, the only definitive therapy for intestinal failure, is plagued by severe complications associated with intestinal barrier breakdown including the translocation of bacteria. Currently, clinical intestinal transplantation (IT) employs static cold storage (CS), however, normothermic machine perfusion (NMP) has significantly improved the outcome of solid organ transplantation beyond the intestine. Our preliminary work demonstrates that NMP significantly reduces intestinal epithelial damage compared to CS. The objective of this study was to evaluate the impact of NMP on epithelial

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21

Yu-Kemp, Hui-Chia, Rachel A. Szymanski, Daniel B. Cortes, et al. "Micron-scale supramolecular myosin arrays help mediate cytoskeletal assembly at mature adherens junctions." Journal of Cell Biology 221, no. 1 (2021). http://dx.doi.org/10.1083/jcb.202103074.

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Epithelial cells assemble specialized actomyosin structures at E-Cadherin–based cell–cell junctions, and the force exerted drives cell shape change during morphogenesis. The mechanisms that build this supramolecular actomyosin structure remain unclear. We used ZO-knockdown MDCK cells, which assemble a robust, polarized, and highly organized actomyosin cytoskeleton at the zonula adherens, combining genetic and pharmacologic approaches with superresolution microscopy to define molecular machines required. To our surprise, inhibiting individual actin assembly pathways (Arp2/3, formins, or Ena/VAS

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Akita, K., K. Hasegawa, M. S. Maurer, et al. "Prediction of acute heart failure events in patients with hypertrophic cardiomyopathy using RNA-Sequencing of plasma small non-coding RNAs." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.1840.

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Abstract Background Hypertrophic cardiomyopathy (HCM) often causes acute heart failure (HF) events, which lead to worse quality of life and prognosis of patients with HCM. The recent emergence of cardiac myosin inhibitors to treat HCM highlights the clinical significance of identifying patients with HCM at high risk of developing acute HF events. However, no tools are available to predict acute HF events in HCM. Furthermore, the underlying molecular mechanisms responsible for the development of HF in HCM remain uncertain. Plasma RNA-sequencing (RNA-Seq) determines concentrations of thousands o

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Sharma, Medha, Tao Jiang, Zi Chen Jiang, Carlos E. Moguel-Lehmer, and Tony JC Harris. "Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material." eLife 10 (August 23, 2021). http://dx.doi.org/10.7554/elife.66929.

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Structures and machines require smoothening of raw materials. Self-organized smoothening guides cell and tissue morphogenesis and is relevant to advanced manufacturing. Across the syncytial Drosophila embryo surface, smooth interfaces form between expanding Arp2/3-based actin caps and surrounding actomyosin networks, demarcating the circumferences of nascent dome-like compartments used for pseudocleavage. We found that forming a smooth and circular boundary of the surrounding actomyosin domain requires Arp2/3 in vivo. To dissect the physical basis of this requirement, we reconstituted the inte

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Quintanilla, Melissa A., John A. Hammer, and Jordan R. Beach. "Non-muscle myosin 2 at a glance." Journal of Cell Science 136, no. 5 (2023). http://dx.doi.org/10.1242/jcs.260890.

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ABSTRACT Non-muscle myosin 2 (NM2) motors are the major contractile machines in most cell types. Unsurprisingly, these ubiquitously expressed actin-based motors power a plethora of subcellular, cellular and multicellular processes. In this Cell Science at a Glance article and the accompanying poster, we review the biochemical properties and mechanisms of regulation of this myosin. We highlight the central role of NM2 in multiple fundamental cellular processes, which include cell migration, cytokinesis, epithelial barrier function and tissue morphogenesis. In addition, we highlight recent studi

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sprotocols. "High-Magnification In Vivo Imaging of Xenopus Embryos for Cell and Developmental Biology." December 30, 2014. https://doi.org/10.5281/zenodo.13624.

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Authors: Esther K. Kieserman, Chanjae Lee, Ryan S. Gray, Tae Joo Park and John B. Wallingford Corresponding author ([wallingford@mail.utexas.edu](wallingford@mail.utexas.edu)). ### INTRODUCTION Embryos of the frog *Xenopus laevis* are an ideal model system for in vivo imaging of dynamic biological processes, from the inner workings of individual cells to the reshaping of tissues during embryogenesis. Their externally developing embryos are more amenable to in vivo analysis than internally developing mammalian embryos, and the large size of the embryos make them particularly suitable for time-l

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