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Dissertations / Theses on the topic 'Myosin light chain 2'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Warmke, Jeffrey Wayne. "Genetic analysis of myosin light chain-2 function in Drosophila melanogaster /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487677267730356.

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2

Cobban, Hannah J. "Role of myosin light chainâ†2â†0 phosphorylation in the Ca'2'+ sensitization of smooth muscle contractility." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327107.

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3

Fuller, Geraldine Anne. "ALTERATIONS IN MYOSIN AND MYOCYTE STRUCTURE IN AN EXTREMLY LONG TERM PACING MODEL OF CANINE DILATED CARDIOMYOPATHY." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1038932067.

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4

Chakravorty, Samya. "Role of the Drosophila Melanogaster Indirect Flight Muscles in Flight and Male Courtship Song: Studies on Flightin and Mydson Light Chain - 2." ScholarWorks @ UVM, 2013. http://scholarworks.uvm.edu/graddis/1.

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Complex behaviors using wings have facilitated the insect evolutionary success and diversification. The Drosophila indirect flight muscles (IFM) have evolved a highly ordered myofilament lattice structure and uses oscillatory contractions by pronounced stretch activation mechanism to drive the wings for high powered flight subject to natural selection. Moreover, the IFM is also utilized during small amplitude wing vibrations for species-specific male courtship song (sine and pulse), an important Drosophila mating behavior subject to sexual selection. Unlike flight, the contractile mechanism an

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5

Anderson, Charles Dudley Jr. "Kinase pathways underlying muscarinic activation of colonic longitudinal muscle." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2365.

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The longitudinal muscle layer in gut is the functional opponent to the circular muscle layer during the peristalsis reflex. Differences in innervation of the layers allow for the contraction of one layer that corresponds with the simultaneous relaxation of the other, enabling the passage of gut contents in a controlled fashion. Differences in development have given the cells of the two layers differences in receptor populations, membrane lipid handling, and calcium handling profiles/behaviors. The kinase signaling differences between the two layers is not as well characterized. Upon activa

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6

Tesic, Ivan. "Myosin light chain kinases in Drosophila /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486462702466832.

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7

Rowe, Tony. "Molecular dissection of myosin light chain function." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282103.

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8

Cosper, Marcus S. "Identification of Myosin Light Chain, Myosin Light Chain Phosphatase, and Rho Kinase in the Corpus Cavernosum of the Rat." Connect to resource online, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1244735791.

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9

Willis, Janine Corinth. "Conditions for cardiac muscle myosin regulatory light chain phosphorylation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq64990.pdf.

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10

Fodor, William Lester. "Molecular analysis of human myosin alkali light chain genes /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487588939087998.

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11

Schlott, Sebastian. "Proteinbiochemischer Nachweis der Exprimierung von Myosin und Myosin-Light-Chain-Kinase in Trabekelwerkszellen des Auges." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/207/index.html.

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12

Johnson, Rebecca M. "Myosin light chain-1 is associated with beef carcass tenderness." Connect to resource, 2005. http://hdl.handle.net/1811/426.

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Thesis (Honors)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formattted into pages: contains v, 18 p.; also includes graphics. Includes bibliographical references (p. 16-18). Available online via Ohio State University's Knowledge Bank.

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13

Herring, B. P. "The role of myosin light chain phosphorylation in regulating cardiac contractility." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375035.

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14

Khan, Protiti. "The Role of Myosin Light Chain Kinase and Non Muscle Myosin II In Ras Signaling to ERK." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_theses/177.

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We have previously reported that non-muscle myosin II (NMMII) and myosin light chain kinase (MLCK) are required for oncogenic Ras signaling to ERK in Ki-Ras transformed rat fibroblsasts (Helfman and Pawlak, J. Cell Biochem. 95(5), 1069-80, 2005). Here I examine if MLCK plays a role in ERK signaling in various tumor derived human epithelial cell lines. I also determined whether genetic inhibition of NMMII isoforms IIA and IIB, or MLCK also inhibits ERK activation in the MCF 10A human breast epithelial cell line expressing oncogenic H-Ras. Inhibition of MLCK by pharmacological inhibitors such as

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15

Brack, Andrew Stephen. "The orientation change of the myosin regulatory light chain during muscle contraction." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249603.

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16

Tohtong, Rutaiwan. "Analysis of the in vivo role of myosin regulatory light chain phosphorylation /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487854314873463.

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17

Kampourakis, Thomas. "Orientation of the cardiac myosin regulatory light chain determined by polarized fluorescence." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/orientation-of-the-cardiac-myosin-regulatory-light-chain-determined-by-polarized-fluorescence(f04760ad-8fc6-4926-b3c7-9c2a1bab7799).html.

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The regulatory light chain (RLC) of myosin is a component of the lever arm of the myosin motor in muscle thick filaments. Phosphorylation of RLC by myosin light chain kinase (MLCK) modulates the force and speed of muscle contraction, but the mechanisms of RLC‐mediated regulation in striated muscles are less well understood than those of Ca2+‐dependent regulation via troponin in the thin filament. To help elucidate the role of RLC in muscle regulation, its orientation in the native environment of cardiac muscle cells was measured. Pairs of cysteine residues were genetically introduced into the

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18

Rodriguez, Deyra Marie. "Isolation and characterization of stretchin-myosin light chain kinase mutants in drosophila melanogaster." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1079994503.

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19

Martin, Rex E. (Rex Edward). "Neuroregulation and Myosin Light Chain Phosphorylation in Ascaris Suum Obliquely Striated Skeletal Muscle." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc504635/.

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Extraction and quantitation of myosin light chain two coupled with myograph recordings from Ascaris muscle perfused with calmodulin inhibitors and neurotransmitters in conjunction with their respective agonists and antagonists have been used to establish the regulation of contraction in this muscle. Densitometric tracings of isolectric focusing gels separating the regulatory light chain were used to quantitate phosphorylation in resting, contracted and flaccid muscle. These studies indicated that inhibitory neurostimulation is mediated by a true GABA receptor. Myosin-mediated contraction is re

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20

Toepfer, Christopher. "The role of myosin regulatory light chain phosphorylation in cardiac health and disease." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/30846.

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In this thesis we examined the effect of myosin associated regulatory light chain (RLC) phosphorylation level on cardiac muscle, ensembles and single molecules. We measured the ability of RLC phosphorylation change in muscle to alter force, power and unloaded shortening. The ATPase rate of full length cardiac myosin was determined with a novel protocol using gelsolin capped actin, which allowed novel measurements of myosin ATPase with full length (filamentous) myosin in low ionic strength. Actin gliding assays determined the effects of RLC phosphorylation level on actin gliding velocities unde

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21

Knowles, Andrea Caroline. "Changes in orientation of the essential light chain region of myosin in muscle contraction." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415212.

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22

Almansour, Khaled. "Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760954.

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Oral delivery of therapeutic peptides has been a continuous target for the pharmaceutical industry, as most of these drugs are currently administered by parenteral routes. However, a major challenge limiting the success of oral delivery of these drugs is their poor permeability across the intestinal epithelial barrier. Extensive research efforts have investigated different strategies to overcome the epithelial barrier and enhance the oral bioavailability of therapeutic peptides. One of the most widely used strategies is the application of permeability enhancer (PE) agents that are co-administe

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23

Raytman, Alexander. "Role of Mutations in the Essential Light Chain (ELC) of Myosin in Familial Hypertrophic Cardiomyopathy (FHC)." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_theses/250.

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Force generation and the ability of the heart muscle to contract and correspondingly to beat depends upon multiple interactions between myosin and actin-tropomyosin-troponin, the key proteins of the contractile apparatus. The myosin molecule consists of two heavy chains and two types of light chains, two essential (ELC) and two regulatory (RLC) light chains. We hypothesize that mutations in myosin ELC may affect the ability of myosin to bind to actin, thus producing structurally and/or functionally abnormal sarcomeres effecting heart muscle contraction and relaxation. We believe that this pat

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24

Skoulakis, Efthimios Makis Charalambous. "Analysis of the regulation of alternative splicing of myosin alkali light chain transcipts in Drosophila melanogaster /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487686243820744.

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25

Aslam, Muhammad. "Effect of cAMP-PKA signaling mechanism on barrier function of cultured endothelial cells : role of myosin light chain phosphatase /." Giessen : VVB Laufersweiler, 2007. http://d-nb.info/987804200/04.

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26

Patel, Sejal. "Myosin regulatory light chain phosphorylation and its role in active mechanics and force generation of the heart." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1462361.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed May 4, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 43-48).

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27

Kawano, Yoji, Takeshi Yoshimura, and Kozo Kaibuchi. "Smooth muscle contraction by small GTPase Rho." Nagoya University School of Medicine, 2002. http://hdl.handle.net/2237/5374.

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28

Wang, Ting, Yuka Shimizu, Xiaomin Wu, et al. "Particulate matter disrupts human lung endothelial cell barrier integrity via Rho-dependent pathways." SAGE PUBLICATIONS INC, 2017. http://hdl.handle.net/10150/626005.

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Increased exposure to ambient particulate matter (PM) is associated with elevated morbidity and mortality in patients with cardiopulmonary diseases and cancer. We and others have shown that PM induces lung microvascular barrier dysfunction which potentially enhances the systemic toxicity of PM. However, the mechanisms by which PM disrupts vascular endothelial integrity remain incompletely explored. We hypothesize that PM induces endothelial cell (EC) cytoskeleton rearrangement via Rho GTPase-dependent pathways to facilitate vascular hyperpermeability. Fine PM induced time-dependent activation

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29

de, Freitas Fatima Pestana. "The Importance of Fast Skeletal Regulatory Light Chain in Muscle Contraction." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_theses/97.

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The aim of this project was to produce and study a murine homozygous knock-in model containing a fast skeletal regulatory light chain (RLC) containing a Asp49toAla point mutation. The D49A mutation is in the functional calcium binding loop of RLC, which is believed to modulate muscle contraction in striated muscle. To introduce the mutation, a reversible knock-out/knock-in system was employed. The Cre/Lox-P strategy was used to conditionally knock-in the RLC D49A mutation. The generation of the knock-in mouse was attempted with two different breeding strategies consisting of two Cre mouse line

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30

Schanz, Miriam A. [Verfasser]. "Identifikation und Charakterisierung von Medium Chain Acyl-CoA Dehydrogenase und Myosin Light Chain 4 als neuartige Interaktionspartner des Östrogenrezeptor alpha / Miriam A. Schanz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1064099033/34.

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31

Owens, Sian-Eleri. "Studies of myosin light chain-dependent modulation of tight junction function through the actions of membrane-permeant peptides." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55667/.

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Myosin light chain phosphorylation plays a central role in the regulation of paracellular permeability. The main objective of this study was to design and synthesise membrane-permeant peptide inhibitors of myosin light chain kinase and phosphatase that could potentially decrease and increase paracellular permeability, respectively. Elevated myosin light chain kinase activity, as observed in a variety of inflammatory disease, phosphorylates myosin light chain, to increase paracellular permeability. Initial studies showed a peptide inhibitor of myosin light chain kinase termed PIK could rectify

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32

Ip, Kelvin. "Mechanical integrity of myosin thick filaments of airway smooth muscle in vitro: effects of phosphoryation of the regulatory light chain." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/4131.

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Background and aims: It is known that smooth muscle possesses substantial mechanical plasticity in that it is able to adapt to large changes in length without compromising its ability to generate force. It is believed that structural malleability of the contractile apparatus underlies this plasticity. There is strong evidence suggesting that myosin thick filaments of the muscle are relatively labile and their length in vivo is determined by the equilibrium between monomeric and filamentous myosin. The equilibrium in turn is governed by the state of phosphorylation of the 20-kD regulatory myosi

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33

Chilcoat, Clayton Douglas. "Protein Kinase A Regulates β2 Integrin Avidity Activation and Subsequent Neutrophil Activation via Modulation of Myosin Light Chain Kinase". NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-03312005-093042/.

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β2 integrins are adhesion molecules on the surface of neutrophils. Avidity activation of β2 integrins includes transportation of pre-formed integrins to the cell surface and a conformational change in the integrin to a high-binding state. Upon binding ligand, β2 integrins initiate a signaling cascade that results in activation of the neutrophil to a pro-inflammatory state, and the inhibition of this signal can prevent further activation of the neutrophil. cAMP and it effector protein kinase A (PKA) exert a generally inhibitory effect upon neutrophil activation. PKA has been shown to inactivate

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34

Humphrey, Peter Saah. "Signal transduction mechanisms for stem cell differentation into cardiomyocytes." Thesis, University of Hertfordshire, 2009. http://hdl.handle.net/2299/3760.

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Cardiovascular diseases are among the leading causes of death worldwide and particularly in the developed World. The search for new therapeutic approaches for improving the functions of the damaged heart is therefore a critical endeavour. Myocardial infarction, which can lead to heart failure, is associated with irreversible loss of functional cardiomyocytes. The loss of cardiomyocytes poses a major difficulty for treating the damaged heart since terminally differentiated cardiomyocytes have very limited regeneration potential. Currently, the only effective treatment for severe heart failure i

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35

Alev, Karin. "Difference between myosin light and heavy chain isoforms patterns in fast and slow-twitch skeletal muscle : effect of endurance training /." Online version, 2005. http://dspace.utlib.ee/dspace/bitstream/10062/605/5/alev.pdf.

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36

Carusio, Nunzia. "Role of nitric oxide in the protection of myosin light chain kinase 210 delection against vascular inflammation induced by endotoxins." Strasbourg 1, 2006. http://www.theses.fr/2006STR13232.

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37

Aslam, Muhammad [Verfasser]. "Effect of cAMP-PKA signaling mechanism on barrier function of cultured endothelial cells : role of myosin light chain phosphatase / vorgelegt von Muhammad Aslam." Giessen : VVB Laufersweiler, 2007. http://d-nb.info/988757508/34.

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38

Guimard, Laurent. "Modélisation et synthèse de peptides interagissant avec une protéine cible : application au complexe calmoduline-RS20." Montpellier 1, 1995. http://www.theses.fr/1995MON1T037.

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39

Getz, Todd Michael. "The Regulation of Phosphorylation Events in Platelets." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/213114.

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Physiology<br>Ph.D.<br>Platelets play a vital role in processes of hemostasis and thrombosis under physiological and pathological conditions. Following vascular damage, platelets will accumulate and stably adhere to exposed subendothelial matrixes. The binding of platelet surface receptor Glycoprotein VI (GPVI) to exposed collagen initiates a signaling cascade, which culminates in platelet activation. Stimulation of GPVI pathways results in the generation of thromboxane and causes the platelets to secrete their granule contents. This generated thromboxane as well as constituents released from

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40

Afshar, Mohammad. "Interactions calmoduline-cibles : modélisation moléculaire et approche expérimentale." Montpellier 1, 1995. http://www.theses.fr/1995MON1T029.

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41

Mandilaras, Konstantinos. "A screen for iron metabolism genes that influence circadian rhythms implicates Ferritin 2 Light Chain Homologue in the Drosophila clock." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/3156.

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Heme has been previously implicated in the function of the mammalian circadian clock but there has been no systematic investigation into the interplay between iron homeostasis and circadian rhythms. I have addressed this question in the model organism Drosophila melanogaster using two different approaches. First, I measured the amount and iron content of the iron storage protein ferritin, the activity of the iron sulfur cluster-containing enzyme aconitase and total heme content in whole bodies of Drosophila at different times during the 24-hour day-night cycle. I found no apparent fluctuation

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42

Pillet, Laure-Elise. "Interactions neurogliales dans la déficience intellectuelle : étude du modèle oligophrénine-1 The X-linked mental retardation protein oligophrenin1 controls astrocyte migration and morphology: astrocytes alterations in OPHN1 knock-out mice Connexin 30 controls astroglial polarization during postnatal brain development." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB246.

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La synapse est le lieu de communication entre les neurones à l'origine de nos capacités cognitives. Les mutations des gènes codant pour des protéines synaptiques sont responsables des maladies neurodéveloppementales appelées synaptopathies, recouvrant un large spectre de pathologies, de la déficience intellectuelle aux troubles du spectre autistique. Cependant, il est actuellement établi que les neurones ne sont pas les seuls acteurs au niveau de la synapse. Les astrocytes jouent également un rôle essentiel dans la mise en place du réseau neuronal et le fonctionnement de la synapse. Ils assure

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43

Singh, Prafull Kumar [Verfasser], and Georg [Akademischer Betreuer] Häcker. "Dynein light chain induced oligomerisation of Bim and Bmf regulates apoptosis by determining their stability and neutralisation by anti-apoptotic Bcl-2 proteins." Freiburg : Universität, 2017. http://d-nb.info/1175874906/34.

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44

El, Mehdi Delphine. "Rôle de la forme phosphorylée de la chaine légère régulatrice de la myosine dans la mort programmée des cellules épithéliales alvéolaires." Paris 6, 2005. http://www.theses.fr/2005PA066589.

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45

Mouly, Vincent. "Heterogeneite des cellules musculaires apparaissant au cours du developpement embryonnaire chez les oiseaux : isolement de lignees par l'utilisation d'un virus oncogene." Paris 7, 1988. http://www.theses.fr/1988PA077125.

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Le tissu musculaire est forme par l'association de cellules mononuclees en elements plurinucles, les myotubes, euxmemes associes en fibre musculaire. La mise en culture des myoblastes et l'etude des proteines exprimees dans les myotubes a permis de montrer que trois types de differenciation se succedent au cours des developpements du bourgeon de patte: le premier (4-5eme jour) est caracterise par la formation de petits myotubes exprimant les chaines legeres de la myosine de type mlc::(1f) et mlc::(2s); le deuxieme (6-7eme jour) presentent de grands myotubes exprimant les 4 types de chaines leg

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46

Qasim, Muhammad. "Proteomic investigation of the molecular targets of mycophenolic acid in human cells." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-0006-AE47-4.

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47

Opleta, Karen. "Proteolytic studies on myosin light chain kinase." 1985. http://hdl.handle.net/1993/24380.

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48

Qi, Dake. "Myosin light chain phosphorylation facilitates in vivo myosin filament reassembly after mechanical perturbation." Thesis, 2002. http://hdl.handle.net/2429/12293.

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It is generally believed that the myosin thick filaments in smooth muscle are structurally less stable than those in striated muscle. In vitro studies have shown that phosphorylation of the 20-kD myosin light chain (MLC) facilitates formation of the thick filaments from monomeric myosins in solution. It appears that the structural integrity of the thick filaments can be enhanced by phosphorylation of the MLC. It is however not known whether the transition from monomeric to filamentous myosin occurs in intact smooth muscle when the light chains are phosphorylated during muscle activation.

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49

Liburd, JANINE. "STRUCTURAL INSIGHTS INTO DICTYOSTELIUM DISCOIDEUM MYOSIN LIGHT CHAIN SPECIFICITY." Thesis, 2013. http://hdl.handle.net/1974/7776.

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Myosins are molecular motor proteins involved in cell movement, vesicle and organelle transport by moving along the cytoskeletal actin filaments. They include a myosin heavy chain and at least one myosin light chain (LC). The latter are typically bilobal proteins like calmodulin, where each lobe comprises a pair of EF-hand Ca2+-binding motifs. The LCs bind to ~25-residue IQ motifs that loosely conform to an IQXXXRGXXXR consensus sequence, and impart rigidity that is crucial for myosin function. The highly motile amoeba Dictyostelium discoideum expresses seven class I myosins, two of which

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50

Wang, Ting, Biji Mathew, Xiaomin Wu, et al. "Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury." 2016. http://hdl.handle.net/10150/614982.

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Radiotherapy as a primary treatment for thoracic malignancies induces deleterious effects, such as acute or subacute radiation-induced lung injury (RILI). Although the molecular etiology of RILI is controversial and likely multifactorial, a potentially important cellular target is the lung endothelial cytoskeleton that regulates paracellular gap formation and the influx of macromolecules and fluid to the alveolar space. Here we investigate the central role of a key endothelial cytoskeletal regulatory protein, the nonmuscle isoform of myosin light chain kinase (nmMLCK), in an established murine

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