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Dissertations / Theses on the topic 'Myosin mechanics'

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Published: 14 March 2023

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1

Ökten, Zeynep. "Single molecule mechanics and the myosin family of molecular motors." [S.l.] : [s.n.], 2006. http://www.diss.fu-berlin.de/2006/6/index.html.

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2

Pertici, Irene. "The power output of a myosin II-based nanomachine mimicking the striated muscle." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1041106.

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This thesis reports the realization and first application of a synthetic nanomachine, able to reproduce in vitro the performance emerging from the array arrangement of myosin II motors in the sarcomere of the striated muscle. The nanomachine consists of an ensemble of less than ten myosin dimers from fast skeletal muscle disposed on a functionalized support carried by a piezoelectric nanopositioner and brought to interact with an actin filament attached with the correct polarity via gelsolin to a bead (Bead Tailed Actin, BTA) trapped into the focus of a Dual Laser Optical Tweezers (DLOT). In s

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3

Erzberger, Anna. "Actomyosin mechanics at the cell level." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-197642.

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Almost all animal cells maintain a thin layer of actin filaments and associated proteins underneath the cell membrane. The actomyosin cortex is subject to internal stress patterns which result from the spatiotemporally regulated activity of non-muscle myosin II motors in the actin network. We study how these active stresses drive changes in cell shape and flows within the cortical layer, and how these cytoskeletal deformations and flows govern processes such as cell migration, cell division and organelle transport. Following a continuum mechanics approach, we develop theoretical descriptions f

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4

Bates, Genevieve. "Molecular mechanics of diaphragmatic myosin from a mouse model of Duchenne muscular dystrophy." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97145.

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Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by the absence of dystrophin in the muscle cell membranes, rendering them susceptible to mechanical damage. DMD leads to respiratory or cardiac muscle failure and death. We hypothesized that alterations in contractile protein function contribute to DMD muscle weakness. We measured muscle strip stress, myosin heavy chain (MHC) isoform composition, velocity (ʋmax) of actin propulsion by myosin, and relative myosin force in control and mdx mouse (C57Bl/10) diaphragms. Stress was statistically smaller for mdx (0.23kg/cm2±0.11; m

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5

Iliffe, Cathryn Ann. "The kinetics and mechanics of myosin and subfragment-1 from insect flight muscle." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251800.

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6

Léguillette, Renaud. "Expression of smooth muscle myosin heavy chain isoforms in asthma and their molecular mechanics." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103169.

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Two smooth muscle (SM) myosin heavy chain isoforms, generated by alternative mRNA splicing, differ by the presence (SM-B) or absence (SM-A) of a 7 amino acid insert in the motor domain. The rate of actin filament propulsion (nu max) of SM-B, as measured in the in vitro motility assay, is 2-fold greater than that of SM-A. I investigated the expression and function of these isoforms in healthy SM and in asthma. First, I determined the sequence of the SM-B isoform in human SM and quantified its expression at the mRNA and protein levels in several human organs. The SM-B isoform was mostly expresse

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7

Patel, Sejal. "Myosin regulatory light chain phosphorylation and its role in active mechanics and force generation of the heart." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1462361.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed May 4, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 43-48).

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8

Düttmann, Markus [Verfasser], and Alexander S. [Akademischer Betreuer] Mikhailov. "Elastic Network Models of Proteins - Uncovering the Internal Mechanics of Actin and Myosin / Markus Düttmann. Betreuer: Alexander S. Mikhailov." Berlin : Universitätsbibliothek der Technischen Universität Berlin, 2012. http://d-nb.info/1028912919/34.

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9

Pontén, Eva. "Tendon transfer mechanics and donor muscle properties : implications in surgical correction of upper limb muscle imbalance." Doctoral thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167.

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Tendon transfer surgery is used to improve the hand function of patients with nerve injuries, spinal cord lesions, cerebral palsy (CP), stroke, or muscle injuries. The tendon of a muscle, usually with function opposite that of the lost muscle function, is transferred to the tendon of the deficient muscle. The aim is to balance the wrist and fingers to achieve better hand function. The position, function, and length at which the donor muscle is sutured is essential for the outcome for the procedure. In these studies the significance of the transferred muscle’s morphology, length and apillarizat

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10

Streppa, Laura. "Characterizing mechanical properties of living C2C12 myoblasts with single cell indentation experiments : application to Duchenne muscular dystrophy." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN008/document.

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Cette thèse interdisciplinaire a été dédiée à la caractérisation des propriétés mécaniques de myoblastes (murins et humains) et de myotubes (murins) à l'aide de la microscopie à force atomique (AFM). En modifiant ou en inhibant la dynamique du cytosquelette (CSK) d’actine de ces cellules, nous avons pu montrer que ces propriétés mécaniques variaient. L’enregistrement de courbes de force indentation nous a permis de montrer que la présence de cellules adhérentes introduisait sur les leviers d’AFM un amortissement visqueux supplémentaire à celui d’une paroi solide, et que cet amortissement visqu

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11

Batters, Christopher. "Single molecule mechanical studies of acto-myosin." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414015.

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12

Jackson, Andrew Paul. "The mechanism of the scallop myosin ATPase." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/35258.

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Molluscan adductor muscles display thick filament regulation. A calcium binding site (regulatory domain) near the neck of the myosin molecule is responsible for controlling the ATPase activity, hence the rate of contraction. In the absence of calcium, the ATPase activity is highly suppressed. When calcium binds to the regulatory domain the inhibition is relieved allowing contraction to occur. Steady-state measurements are insufficient to characterise the ATPase activity in detail because of the dominant contribution from unregulated myosin molecules. Therefore spectoscopic techniques, allied t

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13

Blanc, Florian. "Exploring chemo-mechanical transduction in the myosin molecular motor through computer simulations." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF066/document.

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La vie repose sur des conversions d’énergie libre assurées par des machines moléculaires. Parmi elles, la myosine couple l’hydrolyse de l’ATP à la production de force sur l’actine par basculement d’un « bras de levier ». Compléter le cycle requiert une étape de régénération, ou recovery stroke, où le moteur retourne dans sa configuration armée et hydrolyse l’ATP. Comprendre ce couplage chimio-mécanique est critique pour révéler les principes de fonctionnement des moteurs moléculaires. Cette thèse aborde la question via des simulations moléculaires. Partant d’une nouvelle structure cristallogra

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14

Vasquez, Claudia G. (Claudia Gabriela). "Mechanisms of myosin regulation and function during tissue folding." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101504.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2015.<br>Cataloged from PDF version of thesis. "September 2015."<br>Includes bibliographical references.<br>Throughout organismal development, precise three-dimensional organization of tissues is required for proper tissue function. These three-dimensional forms are generated by coordinated cell shape changes that induce global tissue shape changes, such as the transformation of an epithelial sheet into a tube. A model for this transformation occurs early in Drosophila development where approximately 1,000 cells on t

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15

Schwarzl, Sonja M. "Understanding the ATP hydrolysis mechanism in myosin using computer simulation techniques." [S.l. : s.n.], 2005. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-63890.

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Heidelberg, Univ., Diss., 2005.<br>Aus: S.M. Schwarzl, Understanding the ATP hydrolysis mechanism in myosin using computer simulation techniques, Mensch und Buch Verlag Berlin 2006, ISBN 3-86664-044-7.

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16

Barbier, Lucie. "Study of cellular mechanisms allowing dendritic cell migration in restricted spaces." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL028.

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En cas d'infection, les cellules dendritiques matures (CDm) migrent des tissus périphériques vers les ganglions lymphatiques où ils déclenchent la réponse immunitaire adaptative. Ce déplacement impose une série de contraintes physiques sur les CDm. Au niveau cellulaire, la migration des CDm repose sur la contractilité du cytosquelette d’actine et de myosine. Toutefois, la réponse mécanique spécifique qui permet aux CDm d'adapter leur mode de migration aux contraintes physiques n'a pas été entièrement caractérisée. Dans ce travail, nous avons combiné une série d'approches, des outils microfluid

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17

Burns, Ronald Ian Scott. "Kinetic investigation of the mechanism underlying muscle contraction in myofibrils using T.I.R.F. microscopy." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313991.

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18

Qin, Xiang. "Controlling mechanism of basal myosin oscillation in epithelial cells during Drosophila tissue elongation." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30006.

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La morphogenèse des tissus dans les organismes multicellulaires est très importante pour le développement et certaines pathologies. La morphogenèse tissulaire est dirigée par des forces bio-mécaniques générées par des moteurs moléculaires tels que la myosine et transmis via le cytosquelette et les structures d'adhésion à l'intérieur et entre les cellules. La contractilité de la myosine, souvent en mode oscillatoire, a été étudiée principalement au niveau du domaine apical des cellules épithéliales au cours du développement mais très peu au niveau de leur domaine basal. L'oscillation de la myos

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19

Tyreman, Matthew James Allanson. "Single molecule mechanical studies on the head and neck regions of myosin II." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411476.

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20

Sladewski, Thomas Edward. "Molecular Mechanisms Of Mrna Transport By A Class V Myosin And Cytoplasmic Dynein." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/689.

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mRNA localization ensures correct spatial and temporal control of protein synthesis in the cell. Using a single molecule in vitro approach, we provide insight into the mechanisms by which localizing mRNAs are carried by molecular motors on cytoskeletal tracks to their destination. Budding yeast serves as a model system for studying the mechanisms of mRNA transport because localizing mRNAs are moved on actin tracks in the cell by a single class V myosin motor, Myo4p. Molecular motors that specialize in cargo transport are generally double-headed so that they can "walk" for many microns without

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21

Shanely, R. Andrew. "Protein synthesis and myosin heavy chain mRNA in the rat diaphragm during mechanical ventilation." [Gainesville, Fla.] : University of Florida, 2002. http://purl.fcla.edu/fcla/etd/UFE0000607.

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22

Aslam, Muhammad. "Effect of cAMP-PKA signaling mechanism on barrier function of cultured endothelial cells : role of myosin light chain phosphatase /." Giessen : VVB Laufersweiler, 2007. http://d-nb.info/987804200/04.

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23

Khoury, Ziad. "Application of dynamic oscillatory rheology and Fourier transform infrared spectroscopy in the study of the mechanism of myosin gelation." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80301.

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Variable-temperature Fourier transform infrared (VT-FTIR) and circular dichroism (far-UV CD) spectroscopy were employed to investigate the sequence of structural changes responsible for the thermally induced formation of myosin gels with various rheological properties, as measured by dynamic oscillatory rheology, as well as the effects of prior high-pressure processing (HPP) on thermally induced gel formation. The viscoelastic properties of the protein gels were monitored as a function of temperature and were also measured at three fixed temperatures (44, 48, and 68°C). Examination was

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24

Babcock, Joseph M. (Joseph Michel). "Effects of cross-link and myosin motor concentrations on active muscle gel contraction time and extent." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112565.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (page 26).<br>The cytoskeleton is a crucial network of actin filaments that gives the cell its shape, assists in organelle organization, and allows for cell movement. Active muscle gels are a class of materials that that mimic the functionality of the cytoskeleton. Utilizing myosin II motor proteins to initiate contraction events in actin networks, active muscle gels have the unique potential of acting as microscopic ac

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25

Fischer, Andy J. "Muscarinic mechanisms in myopia and ocular growth." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0018/NQ38467.pdf.

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26

Lindqvist, Johan. "Cellular and Molecular Mechanisms Underlying Congenital Myopathy-related Weakness." Doctoral thesis, Uppsala universitet, Klinisk neurofysiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219460.

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Congenital myopathies are a rare and heterogeneous group of diseases. They are primarily characterised by skeletal muscle weakness and disease-specific pathological features. They harshly limit ordinary life and in severe cases, these myopathies are associated with early death of the affected individuals. The congenital myopathies investigated in this thesis are nemaline myopathy and myofibrillar myopathy. These diseases are usually caused by missense mutations in genes encoding myofibrillar proteins, but the exact mechanisms by which the point mutations in these proteins cause the overall wea

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27

Arboleda-Estudillo, Yoana. "Mechanical cell properties in germ layer progenitor migration during zebrafish gastrulation." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-27725.

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Gastrulation leads to the formation of the embryonic germ layers, ectoderm, mesoderm and endoderm, and is the first key morphogenetic process that occurs in development. Gastrulation provides a unique developmental assay system in which to study cellular movements and rearrangements in vivo. The different cell movements occurring during gastrulation take place in a highly coordinated spatial and temporal manner, indicating that they must be controlled by a complex interplay of morphogenetic and inductive events. Generally, cell movement constitutes a highly integrated program of different ce

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28

Norman, Holly. "Cellular and Molecular Mechanisms Underlying Acute Quadriplegic Myopathy : Studies in Experimental Animal Models and Intensive Care Unit Patients." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7133.

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29

Caruel, Matthieu. "Mechanics of Fast Force Recovery in striated muscles." Phd thesis, Ecole Polytechnique X, 2011. http://pastel.archives-ouvertes.fr/pastel-00668301.

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Cette thèse est consacrée à la modélisation de la réponse transitoire d'une fibre musculaire squelettique soumise à des sollicitations mécaniques rapides. A l'échelle du nanomètre, la fibre musculaire contient des filaments d'actine et de myosine regroupés en unités contractiles appelées "sarcomères". Le filament de myosine est un assemblage de moteurs mol ́eculaires qui, en présence d'ATP, s'attachent et se d ́etachent p ́eriodiquement au filament d'actine. Au cours de ce processus d'attachement-détachement, la myosine génère une force lors d'un changement de conformation appelé "power-stroke

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30

Ip, Kelvin. "Mechanical integrity of myosin thick filaments of airway smooth muscle in vitro: effects of phosphoryation of the regulatory light chain." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/4131.

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Background and aims: It is known that smooth muscle possesses substantial mechanical plasticity in that it is able to adapt to large changes in length without compromising its ability to generate force. It is believed that structural malleability of the contractile apparatus underlies this plasticity. There is strong evidence suggesting that myosin thick filaments of the muscle are relatively labile and their length in vivo is determined by the equilibrium between monomeric and filamentous myosin. The equilibrium in turn is governed by the state of phosphorylation of the 20-kD regulatory myosi

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31

Arboleda-Estudillo, Yoana. "Mechanical cell properties in germ layer progenitor migration during zebrafish gastrulation." Doctoral thesis, Max-Planck-Institut für Molekulare Zellbiologie und Genetik, 2009. https://tud.qucosa.de/id/qucosa%3A25271.

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Gastrulation leads to the formation of the embryonic germ layers, ectoderm, mesoderm and endoderm, and is the first key morphogenetic process that occurs in development. Gastrulation provides a unique developmental assay system in which to study cellular movements and rearrangements in vivo. The different cell movements occurring during gastrulation take place in a highly coordinated spatial and temporal manner, indicating that they must be controlled by a complex interplay of morphogenetic and inductive events. Generally, cell movement constitutes a highly integrated program of different ce

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32

Miyake, Masahiro. "Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia." Kyoto University, 2015. http://hdl.handle.net/2433/202669.

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33

Aranjuez, George Gil Fajardo. "Cellular Mechanisms that Promote the Collective Migratory Behavior of Drosophila Border Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488.

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34

Sankara, Narayana Gautham Hari Narayana. "Role of non-muscle myosin-II isoforms in adherens junction biogenesis and collective migration." Thesis, Université de Paris (2019-....), 2019. https://theses.md.univ-paris-diderot.fr/SANKARA_NARAYANA_Gautham_Hari_Naryana_va.pdf.

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La formation et le remodelage des jonctions intercellulaires sont essentiels pour de nombreux processus biologiques tels que la compaction et la morphogenèse de l’embryon, la formation et la cicatrisation des tissus, le maintien de l’homéostasie tissulaire. Il est maintenant bien décrit que la myosine II non musculaire (NMII) agit comme un générateur de force et un support mécanique pour les jonctions adherens (E-cadhérine-dépendantes) lors de la migration collective et de la morphogenèse. Cependant, la contribution de NMII pendant les premières étapes de la formation de jonctions adherens res

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35

Li, Mingxin. "Celluar and Molecular Mechanisms Underlying Regulation of Skeletal Muscle Contraction in Health and Disease." Doctoral thesis, Uppsala universitet, Klinisk neurofysiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123005.

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Morphological changes, genetic modifications, and cell functional alterations are not always parallel. Therefore, assessment of skeletal muscle function is an integral part of the etiological approach. The general objective of this thesis was to look into the cellular and molecular events occurring in skeletal muscle contraction in healthy and diseased condition, using a single fiber preparation and a single fiber in vitro motility assay, in an attempt to approach the underlying mechanisms from different physiological angles. In a body size related muscle contractility study, scaling of actin

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36

Aare, Sudhakar Reddy. "Intensive Care Unit Muscle Wasting : Skeletal Muscle Phenotype and Underlying Molecular Mechanisms." Doctoral thesis, Uppsala universitet, Klinisk neurofysiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180374.

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Acute quadriplegic myopathy (AQM), or critical illness myopathy, is a common debilitating acquired disorder in critically ill intensive care unit (ICU) patients characterized by generalized muscle wasting and weakness of limb and trunk muscles. A preferential loss of the thick filament protein myosin is considered pathognomonic of this disorder, but the myosin loss is observed relatively late during the disease progression. In attempt to explore the potential role of factors considered triggering AQM in sedated mechanically ventilated (MV) ICU patients, we have studied the early effects, prior

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37

Seitz, Laurent B. "Mechanisms affecting post-activation potentiation following voluntary isokinetic knee extension." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2014. https://ro.ecu.edu.au/theses/1557.

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The present research was designed to: 1) determine whether the voluntary PAP effects commonly observed after conditioning activity (CA; i.e. muscular contraction prior to a ‘test’ contraction) are a consequence of acute neuromuscular alterations relating to the CA itself, or whether they simply reflect warm-up and/or familiarisation effects; 2) clarify the influence of the contraction velocity, duration and total work characteristics of the CA on voluntary PAP; 3) determine the factors allowing stronger individuals to express higher level of voluntary PAP; and 4) determine the peripheral and c

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38

Mouton, Jacoba Martina. "The role of novel protein-protein interactions in the function and mechanism of the sarcomeric protein, myosin binding protein H (MyBPH)." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86751.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and mortality, and is a feature of common diseases, such as hypertension and diabetes. It is therefore vital to understand the underlying mechanisms influencing its development. However, investigating the mechanisms underlying LVH in such complex disorders can be challenging. For this reason, many researchers have focused their attention on the autosomal dominant cardiac muscle disorder, hypertrophic cardiomyopathy (HCM), since it is considere

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39

Shelton, Setareh Lillian. "Characterization of mechanisms regulating scleral extracellular matrix remodeling to promote myopia development." Oklahoma City : [s.n.], 2009.

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Holmes, Craig. "Myopia, retirement planning and commitment." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:980da095-60ab-47b5-a4e2-3962085d56ca.

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Decisions made by individuals planning for retirement may be myopic. One way of capturing this myopia is with quasi-hyperbolic discounting. It is well known that such preferences may explain why individuals fail to provide an adequate retirement income for themselves. In this thesis, the quasi-hyperbolic discounting model is applied to a number of other decisions and outcomes related to planning for retirement. There are three main focuses. Firstly, the thesis considers a model where individuals are quasi-hyperbolic discounters over both retirement and saving, and extends the results of Diamon

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41

komariza, Seyed Omid. "ANALYSIS AND MODELING OF THE ROLES OF ACTIN-MYOSIN INTERACTIONS IN BLADDER SMOOTH MUSCLE BIOMECHANICS." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3651.

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Muscle mechanical behavior potentially plays an important role in some of the most common bladder disorders. These include overactive bladder, which can involve involuntary contractions during bladder filling, and impaired contractility or underactive bladder, which may involve weak or incomplete contractions during voiding. Actin-myosin cross-bridges in detrusor smooth muscle (DSM) are responsible for contracting and emptying the bladder. The total tension produced by muscle is the sum of its preload and active tensions. Studies suggest that actin-myosin cross-links are involved in adjustable

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42

Llano-Diez, Monica. "Mechanisms Underlying Intensive Care Unit Muscle Wasting : Intervention Strategies in an Experimental Animal Model and in Intensive Care Unit Patients." Doctoral thesis, Uppsala universitet, Klinisk neurofysiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173466.

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Critically ill patients admitted to the intensive care unit (ICU) commonly develop severe muscle wasting and weakness and consequently impaired muscle function. This not only delays respirator weaning and ICU discharge, but has deleterious effects on morbidity, mortality, financial costs, and quality of life of survivors. Acute Quadriplegic Myopathy (AQM) is one of the most common neuromuscular disorders underlying ICU muscle wasting and paralysis, and is a consequence of modern intensive care interventions, although the exact causes remain unclear. Muscle gene/protein expression, intracellula

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43

Aslam, Muhammad [Verfasser]. "Effect of cAMP-PKA signaling mechanism on barrier function of cultured endothelial cells : role of myosin light chain phosphatase / vorgelegt von Muhammad Aslam." Giessen : VVB Laufersweiler, 2007. http://d-nb.info/988757508/34.

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44

PENNESTRI, MATTEO. "The Mechanism of Myosin Light Chain IQ-motif interaction and its role in the regulation of vesicle traffic in cytokinesis: a structural study." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/439.

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Calmodulina, catene leggere della miosina essenziali e regolatorie sono proteine evolutive che, attraverso il legame con gli IQ motif di proteine bersaglio, regolano processi intracellulari essenziali come il rilascio di vescicole secretorie alle sinapsi, segnali intracellulari e regolazione della divisione cellulare. La calmodulina di lievito Cmd1 e la catena leggera della miosina Mlc1p condividono la capacità di interagire con la miosina di classe V Myo2p e Myo4p e la miosina di classe II Myo1p. Queste miosine sono necessarie per il trasporto di vescicole, organelli e mRNA, orientazione del

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45

Sheshka, Raman. "Le rôle mécanique de " power stroke " dans la contraction musculaire." Phd thesis, Ecole Polytechnique X, 2012. http://pastel.archives-ouvertes.fr/pastel-00784006.

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Cette thèse est consacrée à la modélisation du fonctionnement mécanique de l'interaction myosine II / actine, qui est responsable de la génération de force active dans les muscles squelettiques à l'échelle nanomérique. Les unités contractiles du muscle contiennent les filaments d'actine et de myosine, les derniers sont formés par un assemblage des myosines II. La myosine II est un moteur moléculaire qui s'attache et se détache périodiquement au filament d'actine en présence d'ATP. Afin de comprendre le phénomène de la contraction musculaire d'un point de vue mécanique, nous suivons l'approche

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Kreutziger, Kareen L. "Investigating the molecular mechanisms of cooperative tension generation in skeletal and cardiac muscle by altering acto-myosin interactions and engineering troponin C calcium binding kinetics /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8060.

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Welz, Tobias [Verfasser], and Eugen [Akademischer Betreuer] Kerkhoff. "Mechanisms of force generation for vesicle transport processes: identification and characterisation of the Spir actin nucleator - myosin V motor protein complex / Tobias Welz ; Betreuer: Eugen Kerkhoff." Regensburg : Universitätsbibliothek Regensburg, 2018. http://d-nb.info/1155359461/34.

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McKillop, Daniel F. A. "Studies on the mechanism of regulation of the interaction of actin and myosin subfragment 1 in solution and on the pressure sensitivity of the actomyosin subfragment 1 ATPase." Thesis, University of Bristol, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303879.

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Frey, Margo Tilley. "Development of a Substrate with Photo-Modulatable Rigidity for Probing Spatial and Temporal Responses of Cells to Mechanical Signals: A Dissertation." Digital WPI, 2008. https://digitalcommons.wpi.edu/etd-dissertations/337.

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"Topographical and mechanical properties of adhesive substrates provide important biological cues that affect cell spreading, migration, growth, and differentiation. The phenomenon has led to the increased use of topographically patterned and flexible substrates in studying cultured cells. However, these studies may be complicated by various limitations. For example, the effects of ligand distribution and porosity are affected by topographical features of 3D biological constructs. Similarly, many studies of mechanical cues are compounded with cellular deformation from external forces, or li

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Rayer, Mégane. "Mécanisme de génération de forces par les cellules apoptotiques lors de la morphogenèse de la drosophile." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30169.

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Chaque espèce vivante acquiert une forme qui lui est propre. La génération de forces mécaniques est l'une des stratégies utilisées par les cellules pour sculpter les organes. Lors du développement animal, les forces mécaniques générées dans le plan des jonctions adhérentes sont importantes pour le remodelage des tissus épithéliaux. Ces forces planaires ont été particulièrement étudiées ces dernières années. C'est le cas notamment de la constriction apicale des cellules lors de l'invagination du mésoderme de l'embryon de drosophile. La réduction de l'apex des cellules est considérée comme un pr

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